Digital Commons Network^™

Synthesis Of Gold Nanoparticles Using Hordeum Vulgare Leaf Extract And Their Antibacterial Activity, Mohamed M. Sehree, Shakir Ghazi Gergees, Pakhshan A. Hassan

Karbala International Journal of Modern Science

Plant extracts and gold nanoparticles are promising alternatives for combating antibiotic resistance in light of the increasing bacterial resistance. Leaf extract of barley was used to synthesize gold nanoparticles (AuNPs). Barley gold nanoparticles (BL-AuNPs) were produced by adjusting some reaction parameters. These BL-AuNPs were characterized through employing the UV-visible spectroscopy technique, the scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FTIR), and energy dispersive X-ray spectroscopy (EDX). BL-AuNPs were tested for antibacterial efficacy against two strains of Gram-negative bacteria, clinically isolated and considered as multidrug-resistant pathogens, Acinetobacter baumannii and Salmonella typhi. The antimicrobial efficiency of the compounds was evaluated …

Hypotension-Specific Rapid Response Team Nurse-Geared Protocol, Quennie Xserenity

Walden Dissertations and Doctoral Studies

This doctor of nursing practice (DNP) project was conducted to develop a clinical practice guideline (CPG) to address a gap at a southeastern hospital where frontline nurses often call rapid response teams for severe hypotension without a standard guideline for necessary interventions. Therefore, the practice gap identified at the project site was the lack of a CPG geared for rapid response nurses (RRNs) to use when responding to a call to intervene on a patient with hypotension. RRNs are nurses with advanced clinical training who provide immediate medical care to rapidly hemodynamically declining patients. The guiding question for this DNP …

Standing Up For Medical Microbiology, L.T. Joshi, Timothy J.J. Inglis

Peninsula Dental School

No abstract provided.

Medical Populism And Epistemic Rights, Kurt Christian B. Tubera, Mark Anthony Dacela

Asia-Pacific Social Science Review

Medical populism, a performance-based political style that orchestrates antagonistic relations between the people and medical establishments, has served as a concept for analyzing the politicization of healthcare. With its four fundamental features, that is, invoking knowledge claims contrary to medical experts’ advice, simplifying discourse, dramatizing responses to public health crises, and forging divisions, medical populism compromises our access to accurate medical or public health information. Populist leaders abuse their epistemic authority and betray public trust when they propagate false information, medical or otherwise. And insofar as accurate medical or public health information is an epistemic good that we have the …

Impact Of Antimicrobial-Impregnated Dressings On The Rate Of Periprosthetic Joint Infections In Primary Joint Arthroplasty Surgeries Of The Hip And Knee, Michael Critelli, Janae Rasmussen, Sydney Shindler, Collin Reasch, Aaditya Patel, Mihir Patel, Jesua Law

Student Publications

Periprosthetic joint infections (PJIs), are a serious complication following total joint arthroplasty (TJA) of the hip and knee. Antimicrobialimpregnated dressings (AMIDs) are emerging as an adjunct measure to reduce microbial growth at the surgical site. This literature review examines the evidence regarding iodine and silver AMIDs in primary TJA of the hip and knee. Evidence indicates that use of AMIDs can be highly beneficial in high-risk infection patients, especially silver-based AMIDs to reduce the incidence of PJIs. Studies showed silver- and iodine-based AMIDs have comparable effects on healing wounds colonized by Staphylococcus aureus. There remains debate regarding the appropriate clinical …

Cannabis Use In Women And Sexual Dysfunction, Becky K. Lynn, Julia D. López, Morgan E. Link, E C. Campian

2020-Current year OA Pubs

No abstract provided.

A Study On Combined Effect Of Monoterpenoid Essential Oils And Polyphenols From Grape Pomace On Selected Pathogenic And Probiotic Bacteria Strains, Haona Bao, Cosmas Mwendwa Muasya, Fur-Chi Chen, Agnes Kilonzo-Nthenge, Ying Wu

Food and Animal Sciences Faculty Research

In the current study, the combined effects of essential oils (EOs) and polyphenols (PPs) were investigated as potential antibiotic alternatives. Thymol and carvacrol at a ratio of 1:1 was used as the EO due to their well-proven synergistic antimicrobial effect. The PPs were an extracted and freeze-dried product from grape pomace. The treatment solutions were prepared at the EO to PP ratios of 0:10, 3:7, 5:5, 7:3, and 10:0, at total concentrations ranging from 0 to 1000 ppm. The minimum inhibition concentrations were examined on the pathogenic bacteria strains, namely Escherichia coli O157:H7, Salmonella typhimurium, and Enterococcus cloacae, and a …

1,3,4-Thiadiazole Derivatives As Pi3ks Inhibitor: Design, In Silico Studies, Synthesis, Characterization, And Antimicrobial Evaluation, Dharmvir Singh, Pankaj Kumar, Anoop Kumar, Vivek V. Bhosale, Kalicharan Sharma, Deepak Kumar, Ramchander Khatri, Tanuj Hooda, Amit Lather

Turkish Journal of Chemistry

Since PI3Ks are targeted by a variety of bacterial pathogens, they represent a promising target for host-directed immune therapy and may be beneficial in managing persistent bacterial infections. In the present study, computational studies of 5-(pyridin-4-yl)-1,3,4-thiadiazol-2-amine derivatives for phosphoinositide-3-kinases (PI3Ks) inhibitors were carried out using dock scores, Glide scores, and the MMGBSA dG method, with comparison to standard drugs (ofloxacin and fluconazole). A series of 5-(pyridin-4-yl)-1,3,4-thiadiazol-2-amine derivatives (D1-D17) were synthesized and evaluated for their in vitro antimicrobial activity against both gram-positive and gram-negative bacterial strains, as well as fungal strains, using the tube dilution method. The synthesized compounds were characterized …

Predictive Study Of The Relationship Between Self-Care And Professional Quality Of Life Among Licensed Counselors Impacted By Covid-19, Maria G. Billings

Walden Dissertations and Doctoral Studies

The COVID-19 pandemic has created unprecedented challenges for mental health professionals, significantly increasing burnout and secondary traumatic stress while reducing available resources and limiting opportunities for compassion satisfaction. The purpose of this cross-sectional, quantitative survey study was to determine whether self-care engagement predicts levels of burnout, secondary traumatic stress, and compassion satisfaction among counselors. Grounded in Stamm’s theoretical framework on compassion satisfaction and compassion fatigue, the Self-Care Assessment Worksheet (SCAW) was used to measure self-care engagement, and the Professional Quality of Life Scale (ProQOL-V) was used to assess burnout, secondary traumatic stress, and compassion satisfaction. The sample included 59 licensed …

Modeling Reemergence Of Vaccine-Eliminated Infectious Diseases Under Declining Vaccination In The Us, Mathew V Kiang, Kate M Bubar, Yvonne Maldonado, Peter J Hotez, Nathan C Lo

Faculty, Staff and Students Publications

Importance: Widespread childhood vaccination has eliminated many infectious diseases in the US. However, vaccination rates are declining, and there are ongoing policy debates to reduce the childhood vaccine schedule, which may risk reemergence of previously eliminated infectious diseases.

Objective: To estimate the number of cases and complications in the US under scenarios of declining childhood vaccination for measles, rubella, poliomyelitis, and diphtheria.

Design, setting, and participants: A simulation model was used to assess the importation and dynamic spread of vaccine-preventable infectious diseases across 50 US states and the District of Columbia. The model was parameterized with data on area-specific estimates …

Trends In The Incidence Of Ovarian Cancer Among Premenopausal And Postmenopausal Women In The United States, 2001 To 2021, Victor Adekanmbi, Abbey B Berenson, Batul Shakir, Christine D Hsu, Thao N Hoang, Itunu O Sokale, Tolulope T Sajobi, Fangjian Guo

Faculty, Staff and Students Publications

Background: Ovarian cancer remains the deadliest and leading cause of gynecological cancer-associated mortality in the US. The aim of this study was to characterize the trends in the incidence of ovarian cancer between premenopausal and postmenopausal women to inform future targeted interventions.

Methods: This population-based cross-sectional study analyzed data from the US Cancer Statistics (USCS) database, which covered the whole of the US population between 2001 and 2021. Joinpoint regression was used to compute the average annual percentage change (APC) with 95% confidence interval (CI) and age-standardized incidence rates per 1,000,000 population.

Results: The results showed that the IR of …

Agent-Based Modeling To Stress Test New York State Healthcare Robustness, Brandon Bedenbedner

Northeast Journal of Complex Systems (NEJCS)

This study presents an agent-based model (ABM) to assess the resilience of New York State’s healthcare system during public health crises. The model simulates patient interactions, disease spread, and resource allocation, identifying critical vulnerabilities and evaluating strategies to avoid system collapse. Simulation results indicate that with just 10\% of the population infected, hospitals statewide can reach full capacity within ten days, causing significant care delays and an estimated 32,104 deaths within a 30-day period.

Sensitivity analysis revealed infection rates, base mortality, and travel-related delays as primary drivers of system outcomes. These findings highlight the critical need for expanded surge capacity, …

Effect Of Different Nutrient Media On Mycelial Growth Of Different Species Of Medicinal Mushroom, Luna Ahmad, Fahed Albiski, Ramzi Murshed, Hijazi Mando, Bssam Al Okla

Journal of the Arab American University مجلة الجامعة العربية الامريكية للبحوث

The research was carried out in 2022 in the National Commission for Biotechnology (NCBT). The aim is studying the mycelium growth of 5 commercial strains of four medicinal mushroom: Ganoderma lucidum (G.l), Agaricus blazei (A.b), Hericium erianaceum (H.e) and Lentinus edodes (Tow strains: strain M3782 (L.e1) and strain straw (L.e2)), sourced of Aloha company of USA on four nutrient growth media: Potato Dextrose Agar (PDA), Malt extract Agar (MEA), Sabouroud Dextrose Agar (SDA) and Corn meal agar (CMA). The following mycelium growth parameters were studied: mycelium height (H), mycelium diameter (D), mycelium density (G), growth rate (GR) and growth coefficient …

Human Alveolar Macrophage Response To Mycobacterium Tuberculosis: Immune Characteristics Underlying Large Inter-Individual Variability, Wolfgang Sadee, Ian H. Cheeseman, Audrey Papp, Maciej Pietrzak, Michal Seweryn, Xiaofei Zhou, Shili Lin, Hao Zhang, Blanca I. Restrepo, Yufeng Wang

School of Medicine Publications

Mycobacterium tuberculosis (M.tb) infection infects human alveolar macrophages (HAMs). In freshly isolated HAMs from 28 healthy adults, we observe large inter-individual differences in bacterial uptake and growth, with tenfold variation in M.tb load by 72 h. While M.tb infection triggers expression changes of numerous host mRNAs, we examined which genes are most variably expressed (VE genes) between donors, as potential biomarkers of individual tuberculosis (TB) risk. The HAM RNA transcriptome following infection revealed thousands of differentially expressed (DE) genes and differential secretion of 25/27 proteins. Yet only 324 DE genes represent VE genes detected exclusively among DE genes in …

Sensitivity And Specificity Of Natural Language Processing Systems For Identification Of Hospitalized People Who Use Drugs, Leah Benrubi, Taisuke Sato, Leo K. Westgard, Kyle Zollo-Venecek, Brindet Socrates, Benjamin Sweigart, Jessica P. Ridgway, Joji Suzuki, Yoelkys Morales, David Goodman-Meza, Alysse G. Wurcel

Student Publications

Background: People who use drugs (PWUD) often lack access to optimal harm reduction and substance use disorder treatment tools. Tracking the epidemiology of acute care utilization by PWUD is crucial to improving systems of care. Chart reviews and International Classification of Diseases (ICD) codes are the most common systems of identifying hospitalizations of PWUD but are limited by high labor costs and inaccuracy. This study evaluates whether natural language processing (NLP) enhances the sensitivity and specificity of ICD-10 codes in identifying hospitalizations of PWUD.

Methods: We analyzed admissions at Tufts Medical Center between 2018 and 2023. Two NLP …

Cancer Immunotherapy Clinical Trials To Support Urgently Needed Access In Low- And Middle-Income Countries: A Report From The Sitc Global Access And Impact Committee, Jennifer Dent, Thomas A Odeny, Et Al.

2020-Current year OA Pubs

Cancer is rapidly on the rise as a cause of morbidity and mortality in low- and middle-income countries (LMICs). However, despite the increasing importance of immune checkpoint inhibitors (ICIs) as a pillar of cancer therapy, access in these settings lags well behind that in high-income countries (HICs). Increasing the evaluation of ICIs through local clinical trials and demonstration projects, and inclusion in multinational clinical trials is the first step to improving access. In particular, the epidemiology and clinical presentation of cancer in LMICs is often distinct from that in HICs, and the impact of immune checkpoint blockade in these settings …

Potential Effect Of Statins As Adjuvant Anti‑Tuberculosis Agents: A Short Communication, Mehwish Hanif, Ayesha Tariq, Laiba Zahoor

Digital Journal of Clinical Medicine

Tuberculosis is a chronic pulmonary infectious disease caused by Mycobacterium tuberculosis and can affect other parts of the body such as bones, brain, and lymph nodes (extra pulmonary Tb). Statins, primarily used for hyperlipidemia, have demonstrated anti-inflammatory and immunomodulatory properties that may help prevent and manage TB. They inhibit HMG-CoA reductase, reduce cholesterol synthesis and interfere with phagocytosis crucial for TB infection. Given the rise in resistance to first-line anti-tubercular therapies, Statins have shown promise as adjunctive agents by potentially shortening treatment duration, reducing adverse effects, and improving outcomes, particularly in immunocompromised and diabetic patients. Based on these findings, Statins …

Review Of "The Hidden Victims: Civilian Casualties Of Two World Wars" By Cormac Ó Gráda, Jean-Michel Turcotte

Canadian Military History

Review of The Hidden Victims: Civilian Casualties of Two World Wars by Cormac Ó Gráda

Clinician Experiences And Comfort With Providing Harm Reduction Resources To People Who Use Drugs, Amanda Cahn, Melissa Calica, Erin Mooz, Malia Haddock, Wendy Craig, Tania Strout, Kinna Thakarar

Journal of Maine Medical Center

Introduction: Although there is extensive evidence supporting harm reduction strategies for managing substance use disorders, wide implementation in clinical settings has been limited. In this study, we examined clinicians’ harm reduction experiences and comfort with providing harm reduction resources.

Methods: In this cross-sectional study, we distributed surveys electronically to clinicians employed in our institution’s outpatient and inpatient settings. We measured comfort using a 10-point scale and practices by asking participants if they had prescribed or provided specific harm reduction resources. We measured perceived importance of various factors in providing harm reduction resources using a 5-point Likert scale.

Results …

Genetic Characterization Of Lpai-H4n2 And H4n8 Viruses Recovered From Free-Grazing Ducks In Thailand, Supanat Boonyapisitsopa, Supassama Chaiyawong, Kamonpan Charoenkul, Kitikhun Udom, Ekkapat Chamsai, Napawan Bunpapong, Somsak Pakpinyo, Alongkorn Amonsin Prof. Dr.

The Thai Journal of Veterinary Medicine

nfluenza A viruses (IAVs) can infect birds and various mammals. In this study, we retrospectively isolated and characterized IAVs (n=8) from oropharyngeal and cloacal swab samples of free-grazing ducks collected during December 2018 to December 2021, by using egg inoculation and whole-genome sequencing. The IAVs could be subtyped as IAV-H4N2 (n = 3) and IAV-H4N8 (n = 5) using real-time RT-PCR assays. Genetic and phylogenetic analyses revealed that all eight genes of Thai IAV-H4 belong to the Avian Eurasian lineage. Both Thai IAV-H4N2 and IAV-H4N8 exhibited low pathogenic avian influenza (LPAI) characteristics and were susceptible to oseltamivir and amantadine. This …

The Role Of The Hemoglobin-Albumin-Lymphocyte-Platelet (Halp) Score In Deep Neck Infections And Its Relationship With Clinical Parameters, Ayşe Seçi̇l Kayali Di̇nç, Nagi̇han Gülhan Yaşar, Agah Yeni̇çeri̇, Çeti̇n Şahutoğlu, İbrahi̇m Sevi̇m, Meli̇h Çayönü

Turkish Journal of Medical Sciences

Background/aim: Deep neck infections (DNI) are suppurative infections of the cervical spaces, which may lead to life-threatening complications. The HALP score is a laboratory parameter reflecting a patient’s nutritional and inflammatory status. The aim of this study was to compare the HALP scores of patients with DNI with those of a control group. A secondary objective was to investigate the potential relationship between the HALP score and clinical parameters, and to assess its role in determining disease severity.

Materials and methods: The study retrospectively included patients who were hospitalized and treated for DNI. Data were extracted from the hospital’s electronic …

A Study On Covid-19 Outbreak In Cook County Of Illinois, Suraj Powar

Research Papers

This study presents a mathematical model developed to better understand the transmission dynamics of COVID-19 and evaluate the effectiveness of different public health strategies. The model, called SEQIRD, includes of the disease such as exposure, quarantine, infection, recovery, and death. Using real case and death data from Cook County, Illinois, the model closely fits observed trends and captures both pre and post-lockdown dynamics with high accuracy.

Our results show that early intervention significantly reduces total infections, with lockdown imposed even a few days earlier preventing thousands of cases. Through sensitivity analysis, we also identify that parameters such as transmission rate, …

Medicolegal Evaluation Of Pediatric Patients With Injection Neuropathy, Hizir Asliyüksek, Caner Beşkoç, Ömer Faruk Şi̇mşeker, Ni̇han Hande Akçakaya, Adem Karbuz

Turkish Journal of Medical Sciences

Background/aim: Injection neuropathy (IN) is a rare but preventable form of iatrogenic nerve injury, particularly affecting the sciatic nerve when intramuscular injections are administered incorrectly. While IN is uncommon in high-income countries, it remains a sig- nificant public health issue in Türkiye, especially in pediatric populations. The aim of this study is to evaluate pediatric IN cases referred to the Council of Forensic Medicine and highlight medicolegal aspects to inform clinical and legal preventive strategies.

Materials and methods: We retrospectively analyzed 67 pediatric cases (age range: 1–17 years; mean age: 10.5 years; 57 boys, 10 girls) referred to the Council …

Health Impacts And Medical Assistance After Libyan Flood Disaster: Emergency Medical Teams’ Responses, Hakan Güner, Okan Maden, Muhammed Saltuk Deni̇z, Kerem Dost Bi̇lmez, Şükrü Yorulmaz, Mehmet Enes Gökler

Turkish Journal of Medical Sciences

Background/aim: Floods are the most frequent natural disasters and pose direct and indirect health risks, some well-documented and others poorly understood. Epidemiological studies help bridge these gaps and guide effective public health responses.In September 2023, Storm Daniel caused severe flooding in Libya, damaging infrastructure, including healthcare facilities. The disaster affected 250,000 people, displaced 48,000, and claimed 15,000 lives, making it the second deadliest natural disaster of the year. This study aims to assess the characteristics of flood-affected patients to improve disaster preparedness.

Materials and methods: This descriptive study examined disaster victims who visited three clinics established as part of an …

Monoclonal Antibodies Targeting The Fimh Adhesin Protect Against Uropathogenic E. Coli Uti, Edward D B Lopatto, Jesús M Santiago-Borges, Denise A Sanick, Sameer Kumar Malladi, Philippe N Azimzadeh, Morgan W Timm, Isabella F Fox, Aaron J Schmitz, Jackson S Turner, Shaza M Sayed Ahmed, Lillian Ortinau, Nathaniel C Gualberto, Jerome S Pinkner, Karen W Dodson, Ali H Ellebedy, Andrew L Kau, Scott J Hultgren

2020-Current year OA Pubs

As antimicrobial resistance increases, urinary tract infections (UTIs) are expected to pose an increased burden in morbidity and expense on the health care system, increasing the need for alternative antibiotic-sparing treatments. Most UTIs are caused by uropathogenic

Effects Of Dormitory Design Factors On Migrant Workers’ Mental Health In Singapore, Tianxiang Lan, Yang Miang Goh, Hanxiao Wang, Xinping Hu

CIB Conferences

Migrant workers face vulnerability and unique mental health challenges in their host countries. Housing designs may affect the residents’ mental health, yet few studies have investigated this relationship in the migrant worker dormitory context. In this study, we investigated this question by surveying the design factors of migrant workers’ dormitories and their mental health states measured by the short version of the Warwick–Edinburgh Mental Wellbeing Scale (SWEMWBS). We found that those migrant workers’ mental health is correlated with whether one has a pleasant window view, defined as green, blue (water feature) or long-distance view. The findings suggest that the elements …

A Data-As-An-Asset Facility Management Framework To Support Hybrid Workplaces And Advance Sustainable Development: Case Studies At Hospitals In China, S. Thomas Ng, Jun Frank Xu, Cheng Zhang, Guanying Huang, Jiajian Zhang

CIB Conferences

Hybrid working that combines home, remote, and in-office working has surged after the COVID-19 pandemic. This working model is disrupting existing facility management practices to (re)shape people-centered hybrid workplaces and advance sustainable development. Collecting, integrating, processing, sharing and analyzing volume and variety of facilities and workspaces data, behavioral and activity data of occupants, environmental data and operational analytics insights remains a major challenge for stakeholders to leverage emerging technologies and digital solutions including digital twin and artificial intelligence to enhance the productivity, operational intelligence, and sustainability of hybrid workplaces. This research proposed a data-as-an-asset facility management framework to support the …

Nosocomial Sepsis Triggered By Pluralibacter Gergoviae In A Pediatric Intensive Care Unit: A Case Report And Literature Review, Abdulrahman Özel, Nurettin Onur Kutlu, Servet Yüce, Cenk Özdalgiçoğlu, Meltem Erol

Journal of Pediatric Infectious Diseases

Pluralibacter gergoviae is a rare opportunistic gram-negative bacillus in humans and exhibits resistance to preservatives in cosmetic products. In this case report, we present nosocomial P. gergoviae sepsis that developed through contamination from a cleaning product in a previously healthy child without known chronic diseases, pediatric intensive care unit care. Contamination with the same microorganism was detected even in unused samples of the cleaning product, leading to a recall of these items. This report highlights the case of hospital-acquired P. gergoviae sepsis to emphasize the importance of adherence to antiseptic protocols by health care work as well as the necessity …

New Insights On The Clinical Significance Of Mycoplasma Pneumoniae-Dna Load In Mycoplasma Pneumoniae Pneumonia, Chen Yu, Lin Chenxi, Huang Rui, Chen Qi, Zhang Min, Chen Ling, Lai Xingqian

Journal of Pediatric Infectious Diseases

Objective: This study aimed to assess the consistency of MP-DNA load in the respiratory tracts, its correlation with Mycoplasma pneumoniae pneumonia (MPP) manifestations, and its predictive value for refractory M. pneumoniae pneumonia (RMPP).

Methods: A retrospective study was performed on a cohort of MPP cases, including 215 patients with positive nasopharyngeal aspirate (NPA) MP-DNA and 59 with positive bronchoalveolar lavage fluid (BALF) MP-DNA. Patients were categorized into two groups based on MP-DNA load: low-load (≤106/mL) and high-load (>106/mL). The consistency of MP-DNA load in NPA and BALF was determined by Spearman’s correlation coefficient. Clinical, laboratory, and radiological data were …

Comparison Of Delta Neutrophil Index And Inflammatory Markers In The Diagnosis Of Late-Onset Neonatal Sepsis In Preterm Infants, Aybuke Yazici, Hayriye Gozde Kanmaz Kutman, Gulsum Kadioglu Simsek, Betul Siyah Bilgin, Fuat Emre Canpolat, Bedia Dinc, Serife Suna Oguz

Journal of Pediatric Infectious Diseases

Objective: To assess the performance of the relatively new hematological marker delta neutrophil index (DNI) and other inflammatory markers in proven sepsis of the very preterm infant.

Methods: Infants with a gestational age of <32 weeks and examined for suspected late-onset sepsis (LOS) were evaluated retrospectively. Demographic characteristics, laboratory findings, and neonatal morbidity and mortality were compared between infants with blood culture-confirmed sepsis and clinical sepsis.

Results: The study included 358 infants, 90 with proven sepsis and 268 with clinical sepsis. The mean gestational ages in these groups were 28.2±2 and 28.2±2.1 weeks, and the mean birth weight was 1139±372 and 1148±370 g, respectively (p>0.05). The proven sepsis group had higher DNI (median 7.1% [range, 0.1-74] vs. 0.6% [range, 0.1-24.7%], p<0.01], CRP (median 5 [range, 1-38] mg/L vs. 1 [range, 1-15] mg/L, p<0.001), interleukin 6 (median 620 [range, 6.9-5500] pg/mL vs. 42.2 [range, 2.2-5500] pg/mL, p<0.01), and procalcitonin (median 6.2 [range, 0.26-86] μg/L vs. 0.6 [range, 0.06-25.7] μg/L, p=0.002). According to ROC analysis, interleukin 6 had the highest area under the curve (AUC) at 0.74 (95% CI 0.60-0.88, p<0.01). The AUC values were 0.73 (95% CI 0.59-0.88, p=0.01) for procalcitonin, 0.62 (95% CI 0.44-0.80, p=0.18) for DNI, and 0.66 (95% CI 0.50-0.82, p=0.05) for CRP.

Conclusion: The delta neutrophil index showed a statistically significant elevation …