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Association Of Respiratory Viruses With Febrile Seizures: A Two-Year Observational Study, Ivana Clara Trittler-Ugidos, Fernando Paredes-Carmona, Núria Visa-Reñé Jul 2025

Association Of Respiratory Viruses With Febrile Seizures: A Two-Year Observational Study, Ivana Clara Trittler-Ugidos, Fernando Paredes-Carmona, Núria Visa-Reñé

Journal of Pediatric Infectious Diseases

Objective: This study aims to explore the association between respiratory viruses and febrile seizures (FS), and to analyze the impact of these viruses on the type and management of FS. Methods: We conducted a retrospective, single-center study of 49,445 emergency cases from September 2021 to December 2023. Among these, 266 patients with FS were identified. Nasopharyngeal swabs were performed to detect respiratory viruses. We categorized FS into simple febrile seizures (SFS) and complex febrile seizures (CFS) based on established criteria. Results: Of the 266 FS cases, 150 had a nasopharyngeal swab and 76.6% were positive for respiratory viruses. The most …


Prognostic Value And Clinical Influence Of Long Non-Coding Rna Small Nucleolar Rna Host Gene 1 Expression In Pediatric Pneumonia, Xin Wang, Jiajia Xu, Jingjing Han Jul 2025

Prognostic Value And Clinical Influence Of Long Non-Coding Rna Small Nucleolar Rna Host Gene 1 Expression In Pediatric Pneumonia, Xin Wang, Jiajia Xu, Jingjing Han

Journal of Pediatric Infectious Diseases

Objective: Severe pediatric pneumonia is characterized by acute onset and rapid progression, posing a serious threat to patients' lives. Accurate assessment of the severity of pneumonia is essential for clinical decision-making and prognostication. Studies of acute lung injury and lung cancer have revealed a significant increase in the expression of the long non-coding RNA (lncRNA) small nucleolar RNA host gene 1 (SNHG1) in cells, suggesting that SNHG1 is likely to play an important role in the progression of lung disease. Methods: 72 children with mild pneumonia, 58 children with severe pneumonia and 135 healthy children were selected as study subjects. …


Utility And Impact Analysis Of Inpatient Pediatric Physiologic Monitoring, Anand Gourishankar, Monaliza Evangelista, Misti Ellsworth, Jean Hsu Jul 2025

Utility And Impact Analysis Of Inpatient Pediatric Physiologic Monitoring, Anand Gourishankar, Monaliza Evangelista, Misti Ellsworth, Jean Hsu

Journal of Pediatric Intensive Care

Objective: This study aimed to study the practice and effect of monitoring pediatric patients in the length of stay (LOS). Methods: We performed a prospective, observational study of pediatric patients in the general ward from October to December 2016. We have recorded the use of cardiac, pulse-oximeter, or both, and as per physician order at time of patient admission. We have studied the proportions of monitoring at different patient groups. We have applied linear regression model to investigate the relationship between LOS and cardiopulmonary monitoring, orders, and medical complexity. Results: Among 399 patients, patients with cardiac and pulse oximeter monitoring …


Multisystem Inflammatory Syndrome In Children Associated With Covid-19 Infection: A Comprehensive Review, Alejandra Isabel Meza-Contreras, Marcelo Nicolas Galdos-Bejar, Raffo Escalante-Kanashiro Jul 2025

Multisystem Inflammatory Syndrome In Children Associated With Covid-19 Infection: A Comprehensive Review, Alejandra Isabel Meza-Contreras, Marcelo Nicolas Galdos-Bejar, Raffo Escalante-Kanashiro

Journal of Pediatric Intensive Care

Objectives: The Multisystem Inflammatory Syndrome in Children (MIS-C) is a post-infectious syndrome associated with COVID-19 disease in children. The aim of this study is to conduct a thorough review to assist healthcare professionals in diagnosis and management of this complication of COVID-19 disease in children Material and Methods: A thorough systematic review was conducted through an on-line search based on MIS-C with the primary focus on epidemiology, clinical characteristics, diagnosis, pathophysiology, management and long-term follow-up. Results: This syndrome is characterized by an exaggerated and uncontrolled release of pro-inflammatory cytokines involving dysfunction of both innate and adaptive immunity. In this review, …


Correlation Of Ultrasound-Based Hydration Assessment Measures With Cvp And Clinical Hydration Status Among Children Admitted To The Picu: A Prospective Observational Study, Sandeep Tripathi, Tara Osman, Mina Hafzallah, Kejin Lee, Drew A. Whalen Jul 2025

Correlation Of Ultrasound-Based Hydration Assessment Measures With Cvp And Clinical Hydration Status Among Children Admitted To The Picu: A Prospective Observational Study, Sandeep Tripathi, Tara Osman, Mina Hafzallah, Kejin Lee, Drew A. Whalen

Journal of Pediatric Intensive Care

Purpose: To assess the correlation of respiratory variation in IVC with CVP in children. Secondary objective was to evaluate IVC variability with clinical hydration status. Methods: IVC variability assessed at the subcostal (SC), and right lateral (RL) region and collapsibility index (CI) (spontaneously breathing) and distensibility index (DI) (positive pressure) and IVC/Aortic ratio calculated. Partial correlations calculated between CI/DI with CVP adjusting for BMI & age. Sensitivity of CI & DI to predict clinical dehydration calculated using ROC curves. Results: 145 ultrasounds on 72 patients (41% positive pressure). Only RL CI in spontaneously breathing patients strongly correlated with CVP (r …


Teachers' Perspectives On Teacher Retention In Early Childhood Programs, Christopher Lavon Curry Jul 2025

Teachers' Perspectives On Teacher Retention In Early Childhood Programs, Christopher Lavon Curry

Walden Dissertations and Doctoral Studies

In a Midwestern state, teacher shortages have intensified the retention challenges of prekindergarten and kindergarten (PreK–K) teachers in early childhood (EC) programs. The problem addressed in this study was the retention of PreK–K teachers in EC programs and schools at the local level. Grounded in dual-factor and coping-competence- context theories, the purpose of this basic qualitative study was to explore teachers’ perspectives of the factors affecting the retention of PreK–K teachers in EC programs at the local level. Data were collected through semistructured interviews with 12 PreK–K teachers in a Midwestern state, who had a minimum of 3 years of …


Conceptualizing Covid-19 As A Biosecurity Threat To The National Security Of Twelve Countries: Implications For Global Health Policy, Lydia Donkor Jul 2025

Conceptualizing Covid-19 As A Biosecurity Threat To The National Security Of Twelve Countries: Implications For Global Health Policy, Lydia Donkor

Doctoral Dissertations and Projects

Biosecurity threats, including diseases such as COVID-19, influence public health and national security policies. The COVID-19 outbreak in Wuhan, China, reveals the risks of biological agents to public health. This study investigates how varying perceptions of COVID-19 as a biosecurity threat affected public policy in 12 countries, including the United States (U.S.), the United Kingdom (U.K.), China, and Ghana, aligning with the Copenhagen School's Securitization Theory and employing causal inference methods. This research used qualitative document analysis to examine government responses to COVID-19 within a security framework among the research participants. The findings demonstrate that nations that viewed COVID-19 as …


Participant Engagement In A National Longitudinal Study Of Covid-19: Insights From The Inspire Study, Kris Pui Kwan Ma, Tracy Stober, Michael Gottlieb, Rachel E. Geyer, Kristin L. Rising, Sharon Saydah, Michelle Santangelo, Kristyn Gatling, Dylan Grau, Ralph C. Wang, Juan Carlos Montoy, Ahamed Idris, Samuel Macdonald, Mandy J. Hill, Ryan Huebinger, Maria G. Prado, Nicole L. Gentile, Erica Spatz, Caitlin Maliki, Jocelyn Dorney, Joann G. Elmore, Michelle L'Hommedieu, Robert A Weinstein, Arjun K. Venkatesh, Kari A. Stephens Jul 2025

Participant Engagement In A National Longitudinal Study Of Covid-19: Insights From The Inspire Study, Kris Pui Kwan Ma, Tracy Stober, Michael Gottlieb, Rachel E. Geyer, Kristin L. Rising, Sharon Saydah, Michelle Santangelo, Kristyn Gatling, Dylan Grau, Ralph C. Wang, Juan Carlos Montoy, Ahamed Idris, Samuel Macdonald, Mandy J. Hill, Ryan Huebinger, Maria G. Prado, Nicole L. Gentile, Erica Spatz, Caitlin Maliki, Jocelyn Dorney, Joann G. Elmore, Michelle L'Hommedieu, Robert A Weinstein, Arjun K. Venkatesh, Kari A. Stephens

Department of Emergency Medicine Faculty Papers

OBJECTIVE: To examine participants' motivations and their experiences throughout a decentralized, longitudinal COVID-19 study in the U.S.

METHODS: We recruited 355 participants from the Innovative Support for Patients with SARS-CoV-2 Infections Registry (INSPIRE) between November 2022 - March 2023 to answer five qualitative survey questions anonymously. We used an inductive content analysis approach to analyze the data.

RESULTS: We identified five key themes from the analysis, which reflected participants' a) motivations to join the study, b) study benefits, c) perceptions of survey questions, d) experiences with the research process, and e) preferences for disseminating research findings. Participants were motivated to …


Leading Through Critical Incidents: A Phenomenological Study Of K–12 School Leaders’ Responses To Critical Incidents, Terry-Ann Griffin Jul 2025

Leading Through Critical Incidents: A Phenomenological Study Of K–12 School Leaders’ Responses To Critical Incidents, Terry-Ann Griffin

Doctoral Dissertations and Projects

The purpose of this transcendental phenomenological study was to explore how K–12 school leaders respond to critical incidents in schools. A critical incident is any actual or alleged event or situation that creates a significant risk of substantial or severe harm to physical or mental health, safety, or well-being. The study focused on three major critical incidents: school shootings/gun violence, the COVID-19 pandemic, and racial unrest. The research was guided by Bandura’s Social Cognitive Theory, which explains human behavior through reciprocal interactions between personal, environmental, and behavioral factors. The central research question was: How do K–12 school leaders respond to …


Enhancing Hypertension Management In Correctional Facilities: Educating Advanced Practice Providers On Effective Strategies, Kimbreya E. Otey Jul 2025

Enhancing Hypertension Management In Correctional Facilities: Educating Advanced Practice Providers On Effective Strategies, Kimbreya E. Otey

Doctoral Dissertations and Projects

Hypertension is a leading risk factor for cardiovascular disease and remains a significant public health concern, particularly within correctional facilities where access to consistent guideline-based care is often limited. Incarcerated individuals experience higher rates of chronic conditions, including hypertension, yet standardized approaches to management are frequently lacking. To address this gap, an evidence-based educational program was developed for nurse practitioners (NPs) and physician assistants (PAs) working in the correctional setting. Grounded in the International Society of Hypertension (ISH) guidelines, the program was developed to enhance awareness and knowledge among NPs and PAs regarding evidence-based hypertension management practices using the International …


Iowa Test Scores Before And After Covid-19 In Early Adolescents, Carmel F. W. Ontoy Jul 2025

Iowa Test Scores Before And After Covid-19 In Early Adolescents, Carmel F. W. Ontoy

Doctoral Dissertations and Projects

This paper addresses past research that examined the effects of COVID-19 on academics and presents a study further examining an area of academics before and after COVID-19. Research relating to COVID-19 has varied, studying correlations and effects on factors such as mental health and relationships. Researchers and educators projected various degrees of learning loss, and while some studies have revealed some loss, others have revealed little to no change. Further research is needed to continue developing researchers’ and educators’ understanding of how COVID-19 and the shift to online learning may have been related to learning and academics of young adolescents. …


The Christian Impact On Addiction Recovery In The Revive And Restore Recovery Ministry In Westmoreland County, Pennsylvania, Donald Albert Walczak Jul 2025

The Christian Impact On Addiction Recovery In The Revive And Restore Recovery Ministry In Westmoreland County, Pennsylvania, Donald Albert Walczak

Doctoral Dissertations and Projects

The problem at Revive and Restore Recovery Ministry is that participants fail to grasp the importance of a biblically based approach to addiction recovery. The purpose of this action research project is to develop a written plan that implements an effective Christian-based approach to addiction recovery. The field of addiction recovery provides a multi-faceted approach to accomplish healing for individuals seeking wholeness and healing. The primary goal of this study is to develop a viable Christian recovery model. The implementation of this model will be detailed in the research. Research methods include the gathering of basic data points through the …


No Evidence Of Pitavastatin Effect On Muscle Area Or Density Among People With Hiv, Kristine M Erlandson, Triin Umbleja, Heather J Ribaudo, Michael T Lu, Jana Taron, Marissa R Diggs, Pamela S Douglas, Kathleen V Fitch, Carl J Fichtenbaum, Markella V Zanni, Judith A Aberg, Maria C Rodriguez-Barradas, Katharine Breaux, Rosalba Gomez Morones, Craig A Sponseller, Judith S Currier, Gerald S Bloomfield, Sarah M Chu, Alex B Lu, Carlos D Malvestutto, Steven K Grinspoon, Todd T Brown Jul 2025

No Evidence Of Pitavastatin Effect On Muscle Area Or Density Among People With Hiv, Kristine M Erlandson, Triin Umbleja, Heather J Ribaudo, Michael T Lu, Jana Taron, Marissa R Diggs, Pamela S Douglas, Kathleen V Fitch, Carl J Fichtenbaum, Markella V Zanni, Judith A Aberg, Maria C Rodriguez-Barradas, Katharine Breaux, Rosalba Gomez Morones, Craig A Sponseller, Judith S Currier, Gerald S Bloomfield, Sarah M Chu, Alex B Lu, Carlos D Malvestutto, Steven K Grinspoon, Todd T Brown

Faculty, Staff and Students Publications

Background: Skeletal muscle area (MA) and muscle density (MD) are key determinants of physical function and typically decline with increasing age. Statins have well-known musculoskeletal effects but whether statins impact MA or MD is not well established, especially in the setting of randomized treatment.

Methods: REPRIEVE is a double-blind randomized trial evaluating the effect of pitavastatin for primary prevention of major adverse cardiovascular events in people with HIV (PWH). Thoracic paraspinal, pectoralis, and infraspinatus MA and MD were assessed among Mechanistic Substudy participants with CT at baseline and month 24.

Results: Of 804 substudy participants, 510 remained on study treatment …


No Evidence Of Pitavastatin Effect On Muscle Area Or Density Among People With Hiv, Kristine M Erlandson, Triin Umbleja, Heather J Ribaudo, Michael T Lu, Jana Taron, Marissa R Diggs, Pamela S Douglas, Kathleen V Fitch, Carl J Fichtenbaum, Markella V Zanni, Judith A Aberg, Maria C Rodriguez-Barradas, Katharine Breaux, Rosalba Gomez Morones, Craig A Sponseller, Judith S Currier, Gerald S Bloomfield, Sarah M Chu, Alex B Lu, Carlos D Malvestutto, Steven K Grinspoon, Todd T Brown Jul 2025

No Evidence Of Pitavastatin Effect On Muscle Area Or Density Among People With Hiv, Kristine M Erlandson, Triin Umbleja, Heather J Ribaudo, Michael T Lu, Jana Taron, Marissa R Diggs, Pamela S Douglas, Kathleen V Fitch, Carl J Fichtenbaum, Markella V Zanni, Judith A Aberg, Maria C Rodriguez-Barradas, Katharine Breaux, Rosalba Gomez Morones, Craig A Sponseller, Judith S Currier, Gerald S Bloomfield, Sarah M Chu, Alex B Lu, Carlos D Malvestutto, Steven K Grinspoon, Todd T Brown

Faculty, Staff and Students Publications

Background: Skeletal muscle area (MA) and muscle density (MD) are key determinants of physical function and typically decline with increasing age. Statins have well-known musculoskeletal effects but whether statins impact MA or MD is not well established, especially in the setting of randomized treatment.

Methods: REPRIEVE is a double-blind randomized trial evaluating the effect of pitavastatin for primary prevention of major adverse cardiovascular events in people with HIV (PWH). Thoracic paraspinal, pectoralis, and infraspinatus MA and MD were assessed among Mechanistic Substudy participants with CT at baseline and month 24.

Results: Of 804 substudy participants, 510 remained on study treatment …


Thrombocytopenia In Patients With Plasmodium Vivax In Colombia Is Associated With Anti-Phosphatidylserine Autoantibodies And Il-6, Ifnγ, Il-10 And Tgf-Β, María Camila Velasco-Pareja, Catalina Tovar-Acero, Miriam E. Cantero Guevara, Ana Rodriguez, Juan Rivera-Correa, María Fernanda Yasnot-Acosta Jul 2025

Thrombocytopenia In Patients With Plasmodium Vivax In Colombia Is Associated With Anti-Phosphatidylserine Autoantibodies And Il-6, Ifnγ, Il-10 And Tgf-Β, María Camila Velasco-Pareja, Catalina Tovar-Acero, Miriam E. Cantero Guevara, Ana Rodriguez, Juan Rivera-Correa, María Fernanda Yasnot-Acosta

Publications and Research

Plasmodium vivax is the most widely distributed human protozoan in the world. It is a causative agent of malaria, with thrombocytopenia being a frequent complication. This study aimed to evaluate the effect of P. vivax infection on plasma cytokine/chemokine levels and anti-phosphatidylserine (anti-PS) autoantibodies, to explore their potential role in thrombocytopenia during P. vivax malaria in Córdoba, Colombia. We included patients with P. vivax malaria and thrombocytopenia (MT); patients with malaria without thrombocytopenia (M) and healthy controls (HC). Plasma cytokines/chemokines (IL-2, IL-4, IL-1β, TNF-α, IL-17A, IL-6, IL-10, IFNγ, IL-12p70, TGF-β1/IP-10, MCP-1, IL-8) were quantified. Evaluation of autoantibodies was performed by …


Visualisasi Data Dalam Pencegahan Dan Pengendalian Infeksi: Otomasi Data Komite Ppi Rumah Sakit Universitas Indonesia Tahun 2024, Clarissa T. Firjatullah, Kemal N. Siregar, Dara A. Wardhani Jul 2025

Visualisasi Data Dalam Pencegahan Dan Pengendalian Infeksi: Otomasi Data Komite Ppi Rumah Sakit Universitas Indonesia Tahun 2024, Clarissa T. Firjatullah, Kemal N. Siregar, Dara A. Wardhani

Jurnal Biostatistik, Kependudukan, dan Informatika Kesehatan

Health Care Associated Infections (HAIs), salah satu masalah kesehatan yang dapat meningkatkan morbiditas dan mortalitas pasien yang dirawat. Di Asia Tenggara, prevalensi HAIs mencapai 21,6% dengan Indonesia sebagai negara dengan prevalensi tertinggi, yaitu 30,4%. Pencegahan dilakukan melalui surveilans HAIs oleh Komite Pencegahan dan Pengendalian Infeksi (PPI). Tujuan dari studi ini adalah menghasilkan analisis sederhana secara grafis dengan visualisasi data melalui dashboard data infeksi HAIs, NSI, dan audit penerapan PPI di RS UI tahun 2024. Data yang digunakan dari database Komite PPI RS UI adalah kasus Phlebitis, CLABSI, CAUTI, VAP, HAP, SSI, NSI, audit hand hygiene dan penggunaan APD, audit bundles …


Tlr4 Asp299gly Snp (Rs4986790) Protects From Periodontal Inflammatory Destruction By Altering Tlr4 Susceptibility To Lps Stimulation, Franco Cavalla, Cláudia Cristina Biguetti, Ariadne Letra, Renato Silva, Alexandre R. Vieira, Franz J. Strauss, Gustavo P. Garlet Jul 2025

Tlr4 Asp299gly Snp (Rs4986790) Protects From Periodontal Inflammatory Destruction By Altering Tlr4 Susceptibility To Lps Stimulation, Franco Cavalla, Cláudia Cristina Biguetti, Ariadne Letra, Renato Silva, Alexandre R. Vieira, Franz J. Strauss, Gustavo P. Garlet

School of Podiatric Medicine Publications

Simple Summary

Periodontitis is a common disease that affects the gums and the bone supporting the teeth, often leading to tooth loss. It results from a complex interaction between bacteria and the body’s immune response. Some people are more susceptible than others, and genetics may play a role. In this study, we focused on a genetic variation (called a polymorphism) in a gene known as TLR4, which helps the immune system recognize harmful bacteria. We examined over 1400 individuals from different populations and found that people carrying this specific variation, known as Asp299Gly, were less likely to develop severe periodontal …


Black Men And Health Literacy: Strategies For Improvement In A Digital Age Through The Adaptation Of A Chronic Disease Self-Management Program, Evelina Weidman Sterling, Laura Stevens, Vanessa Robinson-Dooley, Tyler Collette Jul 2025

Black Men And Health Literacy: Strategies For Improvement In A Digital Age Through The Adaptation Of A Chronic Disease Self-Management Program, Evelina Weidman Sterling, Laura Stevens, Vanessa Robinson-Dooley, Tyler Collette

Faculty Articles

Health literacy is a critical determinant of health outcomes, yet it is often overlooked, particularly among marginalized groups. This paper explores the significance of health literacy, with a particular focus on low-income African American and Black (AA/B) men, a population that faces unique challenges due to intersecting factors such as race, gender, socioeconomic status, and educational disparities. We examine how these factors contribute to health literacy gaps, highlighting adverse effects on health outcomes for AA/B men compared to the general population. Additionally, we stress the growing importance of digital literacy in an increasingly technology-driven world. Not actively addressing digital health …


Anti-Dirt Hand Sanitizer: A Zeolite-Enhanced Approach To Hygiene And Microbial Protection, Theo Uskoković, Evangelina Uskoković, Victoria Wu, Vuk Uskoković Jul 2025

Anti-Dirt Hand Sanitizer: A Zeolite-Enhanced Approach To Hygiene And Microbial Protection, Theo Uskoković, Evangelina Uskoković, Victoria Wu, Vuk Uskoković

Administration and Staff Articles and Research

Children love to play with dirt and their outdoor activities oftentimes make their hands heavily soiled. Meanwhile, improper sanitation of the hands prior to making contact with food or bodily fluids can result in potentially dangerous infection. In situations where handwashing is not available, hand sanitizers present a common cleaning agent of choice. However, as it is shown here, standard sanitizers, albeit acting effectively against skin microbes, do not have the ability to remove the dirt deposits off children's hands, where microbial colonies may remain protected against the antiseptic effect of the sanitizer. To circumvent this limitation, we designed and …


Antimicrobial Susceptibility Profiles (Mic And Mmc) Against Mycoplasma Gallisepticum And M. Synoviae Isolated From Chicken Farms In Thailand, Kriengwich Limpavithayakul, Alongkorn Amonsin, Nataya Charoenvisal, Arithat Limsatanun, Katanyu Yangsuk, Sumrit Toopiya, Füsun Güngör, Esther Schonewille, Javier Uriarte, Somsak Pakpinyo Jul 2025

Antimicrobial Susceptibility Profiles (Mic And Mmc) Against Mycoplasma Gallisepticum And M. Synoviae Isolated From Chicken Farms In Thailand, Kriengwich Limpavithayakul, Alongkorn Amonsin, Nataya Charoenvisal, Arithat Limsatanun, Katanyu Yangsuk, Sumrit Toopiya, Füsun Güngör, Esther Schonewille, Javier Uriarte, Somsak Pakpinyo

The Thai Journal of Veterinary Medicine

Mycoplasma gallisepticum (MG) and M. synoviae (MS) are important pathogens causing significant economic losses in poultry production. Disease prevention and control strategies include vaccination, antimicrobial therapy, and strict biosecurity measures. The present study provides, for the first time, both minimum inhibitory concentration (MIC) and minimum mycoplasmacidal concentration (MMC) values as antimicrobial susceptibility profiles of Thai MG and MS field isolates. This study aimed to evaluate the susceptibility of five MG and ten MS isolates to various antimycoplasma drugs: doxycycline, lincomycin-spectinomycin, tiamulin, tilmicosin, tylosin, and tylvalosin, using a microdilution broth assay. For MG isolates, tilmicosin had the highest mean MIC (12.5 …


Stratifying The Population Based On Health Risk: Identification Of Patient Key Health Risk Factors Through Consensus Techniques, Carolina Castagna, Andrew Huff, Aaron Douglas, Phd, Matteo Garofano, Massimo Fabi, Richard W. Hass, Vittorio Maio Jul 2025

Stratifying The Population Based On Health Risk: Identification Of Patient Key Health Risk Factors Through Consensus Techniques, Carolina Castagna, Andrew Huff, Aaron Douglas, Phd, Matteo Garofano, Massimo Fabi, Richard W. Hass, Vittorio Maio

College of Population Health Faculty Papers

BACKGROUND: Risk stratification is a population health management approach that classifies patients according to their health risks and projected care needs. This strategy is especially valuable in primary care, where timely interventions for high-risk individuals can lead to better health outcomes, reduced healthcare expenditures, and a more sustainable healthcare system. The goal of this study was to establish expert consensus on the clinical and sociodemographic patient factors that should be incorporated into a primary care risk stratification tool.

METHODS: A multidisciplinary expert panel of 24 healthcare professionals, including primary care providers (PCPs), specialists, and allied health professionals, was convened in …


Unlocking Efficiency In Real-World Collaborative Studies: A Multi-Site International Study With One-Shot Lossless Glmm Algorithm, Jiayi Tong, Chongliang Luo, Et Al. Jul 2025

Unlocking Efficiency In Real-World Collaborative Studies: A Multi-Site International Study With One-Shot Lossless Glmm Algorithm, Jiayi Tong, Chongliang Luo, Et Al.

2020-Current year OA Pubs

The widespread adoption of real-world data has given rise to numerous healthcare-distributed research networks, but multi-site analyses still face administrative burdens and data privacy challenges. In response, we developed a Collaborative One-shot Lossless Algorithm for Generalized Linear Mixed Models (COLA-GLMM), the first-ever algorithm that achieves both lossless and one-shot properties. COLA-GLMM ensures accuracy against the gold standard of pooled data while requiring only summary statistics and completes within a single communication round, eliminating the usual back-and-forth overhead. We further introduced an enhanced version that employs homomorphic encryption to reduce the risks of summary statistics misuse at the coordinating center. The …


A Cancer Education Needs Assessment: Informing Middle-Aged Female Patients About The Relationships Between Obesity And Women’S Health Concerns In The Reproductive System, Breast, And Endometrial Health, Batul Mirza Jul 2025

A Cancer Education Needs Assessment: Informing Middle-Aged Female Patients About The Relationships Between Obesity And Women’S Health Concerns In The Reproductive System, Breast, And Endometrial Health, Batul Mirza

MUSC Theses and Dissertations

Obesity significantly impacts women’s health, particularly among middle-aged women, by increasing the risk of hormone-sensitive cancers such as breast, endometrial, and reproductive system cancers. This study examines the educational needs of this demographic group regarding obesity-related cancer risks and explores effective intervention strategies. Obesity-induced mechanisms – hormonal imbalances, chronic inflammation, and insulin resistance – drive cancer susceptibility, emphasizing the need for targeted health education. The study employs a qualitative design, which includes interviews with subject matter experts (SMEs) and surveys of middle-aged women. The goal is to assess awareness, perceived barriers, and preferred learning methods. Findings suggest that with many …


Ifn-Β Production Promotes Metabolic Rewiring And Protection Against Oxidative Stress In Hepatitis Delta Virus-Infected Hepatocyte Cultures, Olga A Khomich, Patrick Giavalisco, Romain Parent, George S Krasnov, Peter Tessarz, Philip Meuleman, Rani Burm, Natalia F Zakirova, Jennifer Molle, Enkhtuul Batbold, Eyal Gottlieb, Fabien Zoulim, Alexander V Ivanov, Birke Bartosch Jul 2025

Ifn-Β Production Promotes Metabolic Rewiring And Protection Against Oxidative Stress In Hepatitis Delta Virus-Infected Hepatocyte Cultures, Olga A Khomich, Patrick Giavalisco, Romain Parent, George S Krasnov, Peter Tessarz, Philip Meuleman, Rani Burm, Natalia F Zakirova, Jennifer Molle, Enkhtuul Batbold, Eyal Gottlieb, Fabien Zoulim, Alexander V Ivanov, Birke Bartosch

Faculty, Staff and Student Publications

Type I interferons are secreted in response to various stimuli and are used as a treatment for many diseases, including infections with the hepatitis B virus (HBV) and its satellite virus, hepatitis delta (HDV). HDV significantly aggravates HBV-mediated liver damage and is - in contrast to HBV - a strong inducer of interferon responses, including IFN-β. As the role of IFN- β in liver metabolism is so far ill explored, we studied its impact on hepatocyte metabolism in HDV-infected cultures. Transcriptome analysis, isotope tracing and functional tests on differentiated, HDV-infected hepatocytes showed reduction of mitochondrial TCA cycle and respiratory activity …


Impact Of Sars-Cov-2 On Healthcare And Essential Workers: A Longitudinal Study Of Promis-29 Outcomes, Jocelyn Dorney, Imtiaz Ebna Mannan, Caitlin Malicki, Lauren E. Wisk, Joann Elmore, Kelli N. O'Laughlin, Dana Morse, Kristyn Gatling, Michael Gottlieb, Michelle Santangelo, Michelle L'Hommedieu, Nicole L. Gentile, Sharon Saydah, Mandy J. Hill, Ryan Huebinger, Katherine Riley Martin, Ahamed H. Idris, Efrat Kean, Kevin Schaeffer, Robert M. Rodriguez, Robert A. Weinstein, Erica S. Spatz, Inspire Group Jul 2025

Impact Of Sars-Cov-2 On Healthcare And Essential Workers: A Longitudinal Study Of Promis-29 Outcomes, Jocelyn Dorney, Imtiaz Ebna Mannan, Caitlin Malicki, Lauren E. Wisk, Joann Elmore, Kelli N. O'Laughlin, Dana Morse, Kristyn Gatling, Michael Gottlieb, Michelle Santangelo, Michelle L'Hommedieu, Nicole L. Gentile, Sharon Saydah, Mandy J. Hill, Ryan Huebinger, Katherine Riley Martin, Ahamed H. Idris, Efrat Kean, Kevin Schaeffer, Robert M. Rodriguez, Robert A. Weinstein, Erica S. Spatz, Inspire Group

Department of Emergency Medicine Faculty Papers

IMPORTANCE: The mandatory service of essential workers during the COVID-19 pandemic was associated with high job stress, increased SARS-CoV-2 exposure, and limited time for recovery following infection. Understanding outcomes for frontline workers can inform planning for future pandemics.

OBJECTIVE: To compare patient-reported outcomes by employment type and SARS-CoV-2 status.

DESIGN: Data from the INSPIRE registry, which enrolled COVID-positive and COVID-negative adults between 12/7/2020-8/29/2022 was analyzed. Patient-reported outcomes were collected quarterly over 18 months.

SETTING: Participants were recruited across eight US sites.

PARTICIPANTS: Employed INSPIRE participants who completed a short (3-month) and long-term (12-18 month) survey.

EXPOSURE: SARS-CoV-2 index status and …


Enhanced Restoration Of Covid-19 Ct Scan Images Utilizing Advanced Wiener Filtering Techniques, Warqaa Shaher Alazawee, Marwa Subhi Ibrahim, Raghda Salam Al Mahdawi, Ali Albu-Rghaif, Ahmed Sabri Altaie Jul 2025

Enhanced Restoration Of Covid-19 Ct Scan Images Utilizing Advanced Wiener Filtering Techniques, Warqaa Shaher Alazawee, Marwa Subhi Ibrahim, Raghda Salam Al Mahdawi, Ali Albu-Rghaif, Ahmed Sabri Altaie

Iraqi Journal for Computer Science and Mathematics

COVID-19, caused by the SARS-CoV-2 virus, was declared a global pandemic by the World Health Organization (WHO) and rapidly spread worldwide from late 2019. While Reverse Transcription Polymerase Chain Reaction (RT-PCR) is the primary diagnostic tool, its sensitivity ranges from only 60% to 70%, leading to false negatives. Computed Tomography (CT) imaging has emerged as a valuable alternative for accurate diagnosis; however, the quality of CT images is often degraded by motion-induced blur and additive noise, particularly in children, individuals with mental health conditions, or those with phobias of CT scans. This study aims to enhance COVID-19 CT image quality …


Demographics And Gross Pathology Of Scoters And Scaups Killed By The Cosco Busan Oil Spill In California, Jessie Beck, Ryan D. Carle, Hannahrose Nevins, Susan E.W. De La Cruz, Erica Donnelly-Greenan Jul 2025

Demographics And Gross Pathology Of Scoters And Scaups Killed By The Cosco Busan Oil Spill In California, Jessie Beck, Ryan D. Carle, Hannahrose Nevins, Susan E.W. De La Cruz, Erica Donnelly-Greenan

Marine Ornithology

Unusual wildlife mortality events provide a unique opportunity to collect information on demographics, disease, and body condition in affected wildlife, which may be useful for informing oil spill damage assessments and future spill responses. In November 2007, the Cosco Busan Oil Spill occurred in San Francisco Bay, California, a globally important wintering area for waterfowl. The spill resulted in the mortality of scoters Melanitta spp. and scaups Aythya spp., species that have declined significantly over recent decades. We examined the demography (sex and age ratios) and prevalence of grossly apparent disease (acanthocephalan parasite infection and mycotic disease) in 288 Surf …


The Potential Of Ecologists To Enhance Our Understanding Of Seabird Health, Melanie R. Wells, Annie Philips, Mary-Anne Lea, Scott Carver Jul 2025

The Potential Of Ecologists To Enhance Our Understanding Of Seabird Health, Melanie R. Wells, Annie Philips, Mary-Anne Lea, Scott Carver

Marine Ornithology

Ecologists play a pivotal role in the detection and investigation of population changes in seabirds and by doing so have significant potential to contribute to enhancing knowledge of seabird health. This review highlights key examples in the literature where ecologists have employed diligent passive health surveillance and/or undertaken targeted investigations of seabirds, strategies that have augmented our knowledge of seabird health at individual and population levels. Within the context of One Health, an integrated approach to perceiving and managing health, this review amalgamates veterinarian and ecology disciplines by summarising auxiliary metrics of clinical health that may be considered for incorporation …


Normal Physical Parameters Characterizing Galapagos Marine Birds, Gustavo Jiménez-Uzcátegui, Patricio D. Carrera-Játiva, Soledad Sarzosa, Edison Encalada, Richar Rodríguez-Hidalgo, Erika (Travis) Crook, Christian Sevilla Jul 2025

Normal Physical Parameters Characterizing Galapagos Marine Birds, Gustavo Jiménez-Uzcátegui, Patricio D. Carrera-Játiva, Soledad Sarzosa, Edison Encalada, Richar Rodríguez-Hidalgo, Erika (Travis) Crook, Christian Sevilla

Marine Ornithology

The Galapagos Penguin Spheniscus mendiculus (GAPE), Flightless Cormorant Phalacrocorax harrisi (FLCO), and Waved Albatross Phoebastria irrorata (WAAL) are marine birds that are endemic to the Galapagos Islands. To provide health information for these three species, baseline data on several physiological parameters were collected non-invasively—from individuals and populations appearing to be healthy—during the course of physical examinations that were conducted from 2011–2019. Heart rate, respiratory rate, body temperature, and body condition (weight vs. morphometric measurements) were analyzed as a function of age and sex. Mean heart rate differed significantly between juveniles and adults in all three species. Respiratory rate and body …


Low Prevalence Of Plasmodium And Haemoproteus In Resident Seabirds From Oceanic Islands Off The Brazilian Coast, Philippe N. Mariano, Gisele P. M. Dantas Jul 2025

Low Prevalence Of Plasmodium And Haemoproteus In Resident Seabirds From Oceanic Islands Off The Brazilian Coast, Philippe N. Mariano, Gisele P. M. Dantas

Marine Ornithology

Bird pathogens promote morbidity and mortality that affect bird population stability. In this context, the present study aimed to detect blood intracellular parasites by molecular methods in four species of seabirds, Masked Booby Sula dactylatra, Red-footed Booby S. sula, Brown Booby S. leucogaster, and Magnificent Frigatebird Fregata magnificens, on the Brazilian coast. Blood samples were collected in the Archipelagos of São Pedro and São Paulo, Fernando de Noronha, Atol das Rocas, and Trindade and Martim Vaz. Genomic DNA was extracted with proteinase K digestion and purification with phenol and chloroform. For each sample, three independent polymerase chain reactions were performed …