Digital Commons Network^™

Multicenter, Observational Cohort Study Evaluating Third-Generation Cephalosporin Therapy For Bloodstream Infections Secondary To Enterobacter, Serratia, And Citrobacter Species, Caroline Derrick, P. Brandon Bookstaver, Zhiqiang K. Lu, Christopher M. Bland

Faculty and Student Publications

Objectives: There is debate on whether the use of third-generation cephalosporins (3GC) increases the risk of clinical failure in bloodstream infections (BSIs) caused by chromosomally-mediated AmpC-producing Enterobacterales (CAE). This study evaluates the impact of definitive 3GC therapy versus other antibiotics on clinical outcomes in BSIs due to Enterobacter, Serratia, or Citrobacter species. Methods: This multicenter, retrospective cohort study evaluated adult hospitalized patients with BSIs secondary to Enterobacter, Serratia, or Citrobacter species from 1 January 2006 to 1 September 2014. Definitive 3GC therapy was compared to definitive therapy with other non-3GC antibiotics. Multivariable Cox proportional hazards regression evaluated the impact of …

U.S. Response To Covid-19 Compared To Other Diseases, Brian E. Barton

2020 Symposium Posters

Emergence of a new infectious disease out of China has caused a global reaction to combat the spread. On December 31, 2019, China reported a cluster of cases of pneumonia in people associated with the Huanan Seafood Wholesale Market in Wuhan, Hubei Province. On January 7, 2020, Chinese health authorities confirmed that this cluster was associated with a novel coronavirus, 2019-nCoV. Governments around the world responded to the threat by instituting lockdowns, closing businesses, using experimental medications, and even closing boarders. Citizens responded in kind by increasing social distancing and the usage of personal protective devices such as face masks …

Modeling And Analysis Of Symptomatic And Asymptomatic Infections Of Zika Virus Disease With Non-Monotonic Incidence Rate, Naba Kumar Goswami, B. Shanmukha

Applied Mathematics & Information Sciences

In this Zika virus disease model, we have incorporated a non-monotonic incidence rate for the human to human transmission, which describes the psychological effect from the behavioural change of the susceptible individuals and the crowding effect of the infected individuals. The proposed epidemic model has seven mutually exclusive sub-classes of humans and mosquitoes which are analyzed by a suitable approach to control the Zika virus. Transmission of Zika virus is of three types, which are between human to human, human to mosquito and mosquito to human. The existence, the local stability of the disease-free, and the endemic equilibrium have been …

Development And Initial Validation Of The Covid Stress Scales, Steven Taylor, Caeleigh A. Landry, Michelle M. Paluszek, Thomas A. Fergus, Dean Mckay, Gordon J.G. Asmundsone

Covid-19 Digital Research

Research and clinical observations suggest that during times of pandemic many people exhibit stress- or anxiety-related responses that include fear of becoming infected, fear of coming into contact with possibly contaminated objects or surfaces, fear of foreigners who might be carrying infection (i.e., disease-related xenophobia), fear of the socio-economic consequences of the pandemic, compulsive checking and reassurance-seeking regarding possible pandemic-related threats, and traumatic stress symptoms about the pandemic (e.g., nightmares, intrusive thoughts). We developed the 36-item COVID Stress Scales (CSS) to measure these features, as they pertain to COVID-19. The CSS were developed to better understand and assess COVID-19-related distress. …

Understanding Covid-19 With Single Cell Immune Profiling, Alex Palacio

Creative Activity and Research Day - CARD

Scientists all around the world are coming together for a single goal -- to find the cure for COVID-19; the virus that has sent millions of people worldwide to hospitals and hundreds of thousands of people to their death. While scientists are trying to uncover the mysteries of the virus, 10X Genomics product lines are able to help scientists achieve their goal. With the Single Cell Immune Profiling, scientists around the world are able to study the immune response and antigen specificity of the virus. The Immune Profiling product line is able to study millions of T-Cells and B-Cells on …

Spring/Summer 2020, Full Issue

The Confluence (2009-2020)

No abstract provided.

The Autoimmune System: The Effect Of Physiological Stressors On Autoantibody Glycosylation And Fidelity Of Autoantibody Profiles, Rahil Kheirkhah

Graduate School of Biomedical Sciences Theses and Dissertations

The presence of thousands of autoantibodies (aABs) in the human sera is typical, and therefore it is possible to identify an aAB profile for each individual. In the first part of this thesis, we will show the cerebrospinal fluid also exhibits an extraordinarily complex immunoglobulin G aAB profile that is composed of thousands of aABs. We show that the pattern of expression of individual aABs in CSF closely mimics that in the blood, indicative of a blood-based origin for CSF aABs. In addition, using longitudinal serum samples obtained over a span of nine years, we show remarkable stability in aAB …

2020-05-01_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

Diagnosis And Treatment Of Uti At Gateway Internal Medicine, Kathra Wickam

Cohort VIII

The project is a quality improvement (QI) initiative with a target population concentrated on adult women, between 18 and 99 years of age, presenting with symptoms of urinary tract infection (UTI). The symptoms are often nonspecific, and dipstick urinalysis lacks adequate specificity; empiric treatment leads to substantial antibiotic exposure that ultimately proves unnecessary. The completion of this QI project came about after a ten-day reflective practice, during which I identified a UTI diagnosis and treatment problem in women at Gateway Internal Medicine in El Paso, Texas. The QI project is aimed at reducing inappropriate outpatient antibiotic use and UTI recurrence …

Pneumonia: An Unexpected Graveyard Visitor?, Daniel A. Casas, Jigar Chauhan, Melanie Williams, Jan Sambataro, David Sukhai, Pablo G. Dubon, Jorge Perez

West Florida Division GME Research Day 2020

Community acquired pneumonia caused by Influenza can present with superinfection. On rare occasions, an unexpected organism is discovered.

Novel Infection Status Post Electrocution Requiring A 4th Ray Amputation, William R. Judson, John D. Murphy, Phillip H. Sussman, John N. Harker

West Florida Division GME Research Day 2020

• Prevotella bivia is an anaerobic, non-pigmented, Gram-negative bacillus species that is known to inhabit the human female vaginal tract and oral flora. It is most commonly associated with endometritis and pelvic inflammatory disease.^{1, 2}
• Rarely, P. bivia has been found in the nail bed, chest wall, intervertebral discs, and hip and knee joints.¹ The bacteria has been linked to necrotizing fasciitis, osteomyelitis, or septic arthritis.^{3, 4}
• Only 3 other reports have described P. bivia infections in the upper extremity with one patient requiring amputation2, and one with deep soft tissue infection requiring multiple debridements and extensive tenosynovectomy. …

Building Regional Expertise: Perspectives From Show-Me Echo Participants., Melissa Warne-Griggs, Lea Brandt, Kimberly Hoffman, Tracy Greever-Rice, E Rachel Mutrux

Project ECHO Bibliography

This article highlights four primary care providers that practice in underserved areas in Missouri. Show-Me ECHO (Extension for Community Healthcare Outcomes) provides colleagues opportunities for consultation and Continuing Medical Education (CME) around particular conditions. Through their participation, these providers have 1) enhanced their comfort and skill in diagnosis and treatment, 2) become important regional resources for patients and other providers, and 3) improved access to specialty services in their community.

A Case For Restoration And Recovery Of Zostera Marina L. In The Great Bay Estuary, David M. Burdick, Kenneth J. Edwardson, Thomas Gregory, Kalle Matso, Trevor Mattera, Melissa Paly, Christopher Peter, Frederick Short, Dante D. Torio

PREP Reports & Publications

No abstract provided.

Accelerating Care Through Echo: Case Examples From The Field., Mirna Becevic, Emmanuelle Wallach, Lincoln R. Sheets, Hope Misterovich, Susan Norris, Evelyn Aboagye, Jonathan A Dyer, Bruce R Bacon, Karen Edison, Kristin Sohl

Project ECHO Bibliography

In this article, we describe three life-changing patient cases demonstrating high-quality and timely care they received in their communities, thanks to the Show-Me ECHO project. Early autism diagnosis, a potentially deadly tumor manifesting as a benign-looking rash, a recalcitrant case of hepatitis C: rural and underserved Missourians now have access to state-of-the-art care through their local providers receiving interdisciplinary telementoring on evidence based practices.

Embracing The Power Of Show-Me Echo Learning Communities To Transform Clinical Practice In Missouri., Lea Brandt, Melissa Warne-Griggs, Kimberly Hoffman, Lori Popejoy, E Rachel Mutrux

Project ECHO Bibliography

Show-Me ECHO, a state-funded project, provides access to education within a community of learners in order to optimize healthcare for the citizens of Missouri. Through videoconferencing and case-based review, ECHO shifts professional development from learning about medical problems in isolation to experiential learning as part of a multidisciplinary team. The establishment of a statewide COVID-19 ECHO is allowing a rapid response to this novel, unprecedented, and unanticipated health care crisis. There are many ongoing opportunities for clinicians from across the state to join a Show-Me ECHO learning community as a means to elevate their practice and improve ability to respond …

A Childhood Dream: A Guide To Veterinary Medicine, Kaitlyn Lowe

ESSAI

No abstract provided.

Understanding Violent-Crime Recidivism, J.J. Prescott, Benjamin Pyle, Sonja B. Starr

Notre Dame Law Review

People convicted of violent crimes constitute a majority of the imprisoned population but are generally ignored by existing policies aimed at reducing mass incarceration. Serious efforts to shrink the large footprint of the prison system will need to recognize this fact. This point is especially pressing at the time of this writing, as states and the federal system consider large-scale prison releases motivated by the COVID-19 pandemic. Those convicted of violent crimes constitute a large majority of older prisoners, who are extremely vulnerable to the spread of the virus behind bars. Excluding them from protective measures will deeply undermine those …

A Study Of The Polymicrobial Inhibitory Interactions Between Alcaligenes Faecalis And Staphylococcus Aureus, Blakeley Griffin

Undergraduate Honors Theses

Members of the Staphylococcus genus are found as a part of normal microflora in humans and can commonly be found on the skin or in the nasal cavity. However, these microorganisms can cause serious and life-threatening opportunistic infections when there is a break in the physical barrier of skin. These infections have become difficult to treat as resistant strains emerge, particularly Methicillin Resistant Staphylococcus aureus (MRSA). MRSA has become a commonly acquired nosocomial infection which is difficult to treat with conventional antibiotics of the blactam class. Even Vancomycin, a last resort antibiotic, has been ineffective on some infections. Furthermore, …

Role Of Protein Phosphatase-2a In Regulating Monocyte Activation By Soluble And Crystalline Uric Acid In Gout, Sandy Elsayed

Pharmaceutical Sciences (MS) Theses

Gout is a chronic inflammatory disease caused by the phagocytosis of monosodium urate monohydrate (MSU) crystals by monocytes/macrophages resulting in downstream expression and production of interleukin-1 beta (IL-1β) and chemokines. The activation of monocytes by MSU crystals involves the priming of monocytes with danger signals e.g. lipopolysaccharide (LPS) or soluble uric acid (UA), crystal phagocytosis and subsequent NLRP3 inflammasome activation and conversion of pro-IL-1β to active IL-1β. Protein-phosphatase-2A (PP2A) is a serine/threonine phosphatase that plays an important role in cell growth and inflammation. The prodrug Fingolimod (FTY720) and its phosphorylated active metabolite (p-FTY720) activate intracellular PP2A. We hypothesized that monocyte …

New Onset Psychosis Secondary To Neurosyphilis, Samantha Linda Jane Vu, Lauren Angela Demarco, Francis Butler, Nihal Shah

West Florida Division GME Research Day 2020

Syphilis is a highly contagious sexually transmitted infection (STI) caused by the spirochetal bacterium Treponema pallidum. Transmission occurs through direct contact of painless ulcerative lesions, chancres, located on the genitalia (penis, labia) and oral mucosa. Neurosyphilis is any involvement of the central nervous systems (brain, meninges, or spinal cord) by the bacterium.

The Impact Of Extreme Heat On Environmental Justice Communities In California: Assessing Equity In Climate Action Plans, Karishma S. Becha

Master's Projects and Capstones

Climate change projections suggest extreme heat events will be more frequent over the next few decades. Extreme heat has both negative environmental and social impacts as it affects energy security, public health by increasing the risk of heat-related illnesses and stresses food and crop supply through prolonged droughts. The impacts of extreme heat will also disproportionately affect communities of low economic status. Because of this, there is a need for better climate action plans that can adapt to and mitigate the impacts brought upon by extreme heat that does not disproportionately impact vulnerable communities. This research analyzed local government Climate …

Placing Notes In The Virtual “Western Wall”: Online Memorial Culture In Chinese Social Media, Xiaoyu Zhang

Master's Projects and Capstones

Each society has a unique way of understanding death and coping with mourning. The increasing online mourners in China gradually generated a collective reference to the Weibo account that belongs to the dead, the “Western Wall.” This project searches for answers to two questions: 1) What characterizes Chinese online memorial practice? And how do these practices compare with those in the Western countries? 2) What aspects of Chinese culture and social conditions can explain Chinese online memorial practices? By combining corpus analysis with thematic analysis on 1,606 comments left on the last tweet of two accounts of deceased Weibo users, …

Dermatologists In The Wild West, 1870-1900: The Early Pioneers From The Mississippi River To The Pacific Coast., Leonard J Hoenig, Lawrence Charles Parish

Department of Dermatology and Cutaneous Biology Faculty Papers

During the Wild West era of American history (approximately 1870-1900), at least 53 dermatologists settled between the Mississippi River and the Pacific Coast. In 1870, two dermatologists began their practice in the city of St Louis, Missouri (William Augustus Hardaway and Solomon Claiborne Martin, Sr) and one dermatologist started his practice in San Francisco, California (George J. Bucknall). By 1900, 50 more dermatologists had settled in 19 cities located in the American West (Tables 1,2). There, they established practices, initiated academic programs, and pioneered dermatology as a medical specialty in the western United States. This contribution provides brief biographic profiles …

What's All The Buzzy About? Using Cryotherapy And Vibration For Pain During Vaccinations In Children, Marta L. Byma

Evidence-Based Practice Project Reports

Vaccinations are the most common painful needle procedure, with an estimated 12 billion injections given per year (CDC, 2019). The usual method for administration of vaccinations is through needle puncture, which is often painful. Children often report receiving a shot as one of the most feared and painful experiences (McMurtry et al., 2015). The purpose of this evidence-based practice (EBP) project was to improve patient experiences by decreasing the pain that is associated with vaccinations through the use of a nonpharmacological method for comfort via the Buzzy® device. After thorough analysis and synthesis of the literature, the Buzzy® device that …

Multidrug-Resistant Pseudomonas Aeruginosa Evokes Differential Inflammatory Responses In Human Microglial And Retinal Pigment Epithelial Cells, Poonam Naik, Sukhvinder Singh, Sushma Vishwakarma, Inderjeet Kaur

Open Access archive

Increasing incidences of multidrug-resistant (MDR) pathogens causing endophthalmitis threaten our ability to treat this condition, and the modulation of inflammatory responses by MDR bacteria is not known. In this study, using human microglia and retinal pigment epithelial (RPE) cells, we compare the inflammatory responses of sensitive (S-PA) and multidrug-resistant (MDR-PA) clinical isolates of Pseudomonas aeruginosa. Infected cells were subjected to qPCR analysis, enzyme-linked immunosorbent assay (ELISA), and immunostaining to assess the expression of inflammatory mediators. Both microglia and RPE cells, challenged with S-PA and MDR-PA, induced a time-dependent expression of inflammatory cytokines. Significant differences were observed in expression levels of …

Different Coral Pathogens Causing Disease Through Biofilm Formation And Ways To Study And Disrupt It, Dena Kamel

2020 Spring Honors Capstone Projects - Archive

Coral pathogens have been causing irreversible damage to the coral communities all around the world. Specific genera of bacteria like Vibrio have been studied throughout the years, however, researchers continue to find new species. Some pathogens’ biofilm formation ability negatively impacts the corals. We attempted to optimize the biofilm assay in a specific species Vibrio coralliilyticus in order to learn more about the conditions and variables that affect biofilm formation and to develop a set of conditions that the pathogen deems as ideal. The immediate goal of this research is to be able to quantify biofilm and find factors that …

Targeted Lc-Ms Analysis For Metabolite Profiling From Pathogenic Bacteria, Jessica Gomez-Vargas

2020 Spring Honors Capstone Projects - Archive

Groundwater is relied on for drinking by more than 50 percent of the United States. For this reason, the purity of groundwater is extremely important. There has been possible contamination of opportunistic pathogenic microorganisms in groundwater attributable to oil and gas extractions from drilling and hydraulic fracturing; two of which are Pseudomonas aeruginosa and Bacillus cereus. These pathogens can cause severe infections in humans. P. aeruginosa increases prevalence of chronic and nosocomial infections. B. cereus produces toxins that are one of the most common causes of food poisoning. B. cereus can also cause infections of the eye, respiratory tract, and …

An Analysis Of The Role Of Reality Television In The Representation Of Immigrants On Tlc's Show, 90 Day Fiancé., Morohunfolu Jimade Seton

Electronic Theses and Dissertations

A larger number of people reside outside their country of birth today than in any other time in history, and these levels are expected to continue to rise in the future (International Organization for Migration, 2011). The United States is currently the most popular immigrant destination in the world, with more immigrants than any other country. Immigrants statistics indicate that the immigrant population in the United States reached a record of 44.4 million in 2017 (Pew Research Centre, 2019). Correspondingly, the percentage of immigrants who were admitted into the U.S. as spouses of citizens has increased over of the last …

Louisville's Dark Tourist: Liminality, Legend, And The Macabre., Montgomery Quaid Adams

Electronic Theses and Dissertations

This thesis is a historical and theoretical analysis of touristic motivations behind visiting dark tourist attractions that uses two Louisville, Kentucky attractions as case-studies. It begins by providing an overview of concepts relevant to the analysis of these motivations including liminality, dark tourism, and legend studies, thereby drawing connections between these concepts to develop a framework for the analysis of these liminal spaces and the legends that surround them. It uses these theories to build a framework that argues for the inclusion of legend studies in the conversation of dark tourism and providing a new lens for viewing touristic motivation …

Development Of Rationally Designed Live Attenuated Vaccines For Lassa Fever And Venezuelan Equine Encephalitis., Dylan Macgregor Johnson

Electronic Theses and Dissertations

Lassa Virus (LASV) and Venezuelan Equine Encephalitis Virus (VEEV) are two single stranded RNA viruses belonging to the Arenavirus and Alphavirus families, respectively. Both are emerging pathogens without approved vaccines or treatments. VEEV is an important biothreat pathogen because it has been weaponized and is extremely infectious as an aerosol. VEEV causes biphasic febrile illness that can progress to a viral encephalitis with low mortality, but high morbidity. LASV causes a viral hemorrhagic fever, Lassa Fever (LF), which is endemic in West Africa, and responsible for between 100-500k annual infections with a 1-2% overall mortality rate. ML29 and VEEV TC-83 …