Digital Commons Network^™

Psjh Telehealth Covid-19 Repsonse, Todd Czartoski

Articles, Abstracts, and Reports

No abstract provided.

June 3, 2020 Faculty Senate Minutes, University Of South Carolina

Faculty Senate

No abstract provided.

Addressing The Shortage Of Pathologists In Africa: Creation Of A Mmed Programme In Pathology In Zambia, Victor Mudenda, Evans Malyangu, Shahin Sayed, Kenneth Fleming

Pathology, East Africa

Background: With approximately one pathologist for one million people compared to ratios of approximately 1 to 25 000 in the United States and United Kingdom, there is a severe shortage of pathologists in much of Africa. The situation is particularly severe in Zambia, where, in 2009, the ratio was 1 to 1.4 million.

Objective: To address this, a postgraduate Master of Medicine (MMed) training programme was launched in Lusaka in 2011.

Methods: The process and most significant challenges and lessons learned were documented, as they may be of value to other countries facing similar challenges.

Results: …

The Effects Of Immune Regulation And Dysregulation: Helper T Cell Receptor Affinity, Systemic Lupus Erythematosus And Cancer Risk, And Vaccine Hesitancy, Deborah K. Johnson

Theses and Dissertations

Helper T cells direct the immunological response to foreign pathogens and cancer. To become activated, helper T cells must recognize unique peptides presented on major histocompatibility complex II (pMHCII) by antigen presenting cells (APCs) with their T cell receptor (TCR). While much is known about helper T cell activation signaling cascades and the subsequent roles of helper T cell subsets, the initiation of helper T cell activation by the TCR and other co-receptors is less well understood. Specifically, the affinity of the TCR for its pMHCII can change helper T cell subset fate, proliferation, and alter the risk for activation …

The Health, Economic, And Social Effect Of Covid-19 And Its Response On Gender And Sex: A Literature Review, Hannah Briggs, Thoai Ngo

Poverty, Gender, and Youth

Large-scale emergencies, like the ongoing COVID-19 pandemic, demonstrate pervasive effects across multiple sectors. There is a continually growing body of evidence demonstrating gender and sex differences in COVID-19 disease, as well as its health, social, and economic impacts. While online resources have worked to compile this evidence, there is a need to evaluate and synthesize the available gender- and sex-disaggregated data related to COVID-19. This literature review will systematically assess and compile current literature and evidence from different disciplines. We will include peer reviewed articles, clinical studies and reports, and relevant working papers using secondary data analyses and primary research …

Vol. 48, No. 1: Full Issue, Denver Journal Of International Law & Policy

Denver Journal of International Law & Policy

No abstract provided.

Safe And Effective Disinfection Of Show Cave Infrastructure In A Time Of Covid-19, Hazel A. Barton

International Journal of Speleology

The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, has been responsible for over 650,000 deaths worldwide. Transmission of SARS-CoV-2 occurs primarily through airborne transmission or direct human contact, demonstrating the importance of social distancing measures and the use of face masks to prevent infection. Nonetheless, the persistence of coronavirus on surfaces means that disinfection is important to limit the possibility of contact transmission. In this paper, the potential for various surfaces in show caves to serve as sources for SARS-CoV-2 infection is examined. Given the isoelectric potential (pI) of SARS and SARS-like coronaviruses, it is likely that they are …

2020-06-02_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

Life In The Time Of Covid, Julio A. Ramirez

The University of Louisville Journal of Respiratory Infections

No abstract provided.

Emergency Medicine In The Time Of Covid, Martin Huecker, Jacob Shreffler, Adam Ross, Hugh Shoff, Mary Nan S. Mallory, J. Jeremy Thomas

The University of Louisville Journal of Respiratory Infections

The novelty and uncertainty associated with COVID-19 has created challenges for politicians, citizens, and healthcare providers, leaving no one unaffected. As members of the front line of defense, providers in Emergency Departments (EDs) face the momentous challenge of effectively identifying and treating patients with COVID-19, working with experts in Infectious Disease, Internal Medicine, Critical Care, Public Health, and other disciplines. We must coordinate these efforts while also protecting staff, implementing strategies to reduce transmission, and managing ED patients with conditions unrelated to COVID-19. Striving to maintain a grasp of the rapidly accumulating publications in medical journals and the media, we …

Healthcare Workers In The Time Of Covid, Julio A. Ramirez, Ruth Carrico

The University of Louisville Journal of Respiratory Infections

No abstract provided.

Simulation Analysis Of Beijing H1n1 Influenza Based On Spatial Clustering, Yitong Zhao, Mei Shan, Ma Liang, Zhang Wei

Journal of System Simulation

Abstract: Spatial cluster detection is widely used for disease surveillance, prevention and containment. In the early stages of illness, epidemics have similar symptoms to common diseases, making infectious disease data processing and analysis difficult. The Agent based modeling and simulation was used to generate H1N1 influenza data in Beijing. By designing a set of experiments, the epidemic monitoring results of two spatial clustering algorithms were analyzed. The results show that, using spatial clustering algorithms to analyze the simulation data of the epidemics can help to reveal the spread of the epidemic and play a positive role in the …

Leadership And Followership In A Pandemic - Where Do You Stand?, S Hanks

Peninsula Dental School

Dr SALLY HANKS describes her approach to dental education, and how her research on leadership in general dental practice can help dentists to navigate the challenges of Covid-19.

Psychosocial Impacts And Employment Preparedness Of Participating In An Hiv Peer Program: Implications For Tailoring A Vocational Counseling Model For Plwh, Erin R. Mckinney-Prupis

Dissertations and Theses

Background:

Medical advancements in HIV care should have reduced barriers to employment for PLWH, yet in 2017 only 47.7% of PLWH reported being employed, as compared to 62.9% in the general population. Employment is a significant social determinant of health, it impacts a variety of factors related to health, including earned income, access to healthcare, and social connectedness. Quantitative and qualitative studies have identified several concerns PLWH have about entering the workforce; the most pressing being fear of losing benefits. Targeted work readiness programs for PLWH is an important approach to help PLWH overcome their unique barriers to work, such …

From Theory To Practice: Interdisciplinary Science In Undergraduate Education, Brie Tripp

Dissertations and Theses

Science has undergone a major transformation in the 20th and 21st centuries with new fields emerging at the intersection of disciplines, such as bioethics, bioinformatics, and chemical ecology. Yet, opportunities to engage with interdisciplinary science, and the skills needed to work in these fields, are largely absent from undergraduate biology classrooms. As a consequence, students are potentially deprived of opportunities to think interdisciplinarily and engage with real-world issues that often necessitate interdisciplinary efforts. To be informed citizens in society and forward-thinking scientists in the workforce, undergraduate students will undoubtedly benefit from exposure to these interdisciplinary science experiences.

Given these considerations, …

Impacts Of Rift Valley Fever Virus: A One Health Approach To Assess Burden And Inform Prevention And Control Options, Catherine Machalaba

Dissertations and Theses

Background: Rift Valley Fever (RVF) is a climate-sensitive emerging zoonotic disease associated with large-scale livestock production losses and human disease burden in Sub-Saharan Africa and the Middle East. While recognized as a key One Health issue based on its transmission dynamics involving human, animal and environmental determinants, there has been poor coordination between sectors to reduce the risk and impact of RVF. Efforts to counter the disease remain largely reactive, presenting an ongoing threat to local and global health security. The intent of this dissertation was to improve understanding of the burden of RVF across society and to identify entry …

3,4-Dihydroxyphenylacetate 2,3-Dioxygenase Modulates The Ability Of Enterobacter Hormaechei To Induce Cryptococcus Neoformans Melanization, Amy Nelson

Honors Scholar Theses

In this study, we performed transposon mutagenesis to create a library of Enterobacter hormaechei mutants and developed a melanization assay to identify mutants that could not induce the typical melanization phenotype in Cryptococcus neoformans. Relevant phenotype labels included: “hypomelanizer”, a total lack of melanization; “hypermelanizer”, an increased melanization; or “abnormal”, an increased melanization with complete color change of the assay plate to a reddish-brown. Genomic sequencing of 47 mutants and bioinformatic analysis allowed us to pinpoint the transposon insertion site in each E. hormaechei mutant to identify the genes that were affected. A single mutant that induced the abnormal …

2020-06-01/02 Daily Unm Global Health Covid-19 Briefing, Christophe G. Lambert, Shawn Stoicu, Ingrid Hendrix, Lori D. Sloane, Mari Anixter, Anastasiya Nestsiarovich, Praveen Kumar, Nicolas Lauve, Jenny Situ, Alexandra Yingling, Kristine Tollestrup, Orrin Myers, Douglas J. Perkins

HSC Covid 19 Briefings

Executive Summary:

NM Highlights: New public health order. First coronavirus death in state prison. NM case count. ABQ black lives matter protest. Santa Fe Fiesta canceled. U2 drummer donated to Navajo. US Highlights: Americans’ COVID-19 survey. Immunity for essential businesses in 4 states. International Highlights: Tiananmen Square closed to vigil. Shared approaches helpful for Africa. Economics, Workforce, Supply Chain, PPE: Face masks effective. Distance and Mask combined key to success. Economic effect on dental practice. Dow predicted to fall before new high. Epidemiology Highlights: Other causes of death increase. Virus not losing potency. Protests may spread virus. Wastewater surveillance. Healthcare …

Choice‐Based Reminder Cues: Findings From An Mhealth Study To Improve Tuberculosis (Tb) Treatment Adherence Among The Urban Poor In India, Debasree Das Gupta, Amit Patel, Deepak Saxena, Naoru Koizumi, Poonam Trivedi, Krupali Patel, Devang Raval, Andrew King, Kerianne Chandler

Kinesiology and Health Science Faculty Publications

Poor treatment outcomes due to nonadherence and consequent high levels of drug resistance continue to challenge efforts to combat tuberculosis (TB) in India. Mobile health‐ or mHealth‐based reminder cues have been considered in multiple health behavior modification interventions, including TB treatment nonadherence. We conducted a quasi‐experimental study in Ahmedabad, India, to examine the effectiveness of mHealth‐based reminder cues customized to meet diverse patient needs. Results from this experiment indicate that the potential of customized mHealth reminder cues may remain unrealized unless addressed in conjunction with the multifaceted drivers of TB treatment nonadherence. The perspective we present here has broad relevance …

Student Nurses Exposed To Sustainability Education Can Challenge Practice: A Cohort Study, Jennie Aronsson, Daniel Clarke, Jane Grose, Janet Richardson

School of Nursing and Midwifery

No abstract provided.

Energy Efficiency Evaluation Of Discrete Manufacturing System Based On Improved Entropy Method, Zhuqing Peng, Wang Yan, Zhicheng Ji

Journal of System Simulation

Abstract: For the characteristic of dynamic change randomness, variety, complexity and diversity in discrete manufacturing system, nine evaluation indexes were concluded from four aspects including product, equipment, economy and task flow, and energy efficiency evaluation index construction of discrete manufacturing system was structured. An improved entropy method was proposed. As the discrete degree of an index was too large when the entropy method was used to assign weight, the weight of the index would be very large. The idea of Analytic Hierarchy Model was used to improve the entropy method. So the improved entropy method could evaluate the discrete manufacturing …

Taking The Lead, S Hanks

Peninsula Dental School

Dr SALLY HANKS describes her approach to dental education, and how her research on leadership in general dental practice can help dentists to navigate the challenges of Covid-19.

Don't Go Breakin' My (3d Bioprinted) Heart: Dissecting Patentability And Regulation Of 3d Bioprinted Organs, Anna Marie Whitacre

Journal of Intellectual Property Law

In light of the growing realism of 3D bioprinted organs, legal issues arising from these concerns can easily bleed into our society. This bleeding demands exploration. Should 3D bioprinted organs be regulated as natural organs or as medical devices? Are 3D bioprinted organs patentable? What happens if a 3D bioprinted organ is subject to a successful patent infringement suit? Does the recipient face a Repo Men fate?

The beginning of this note dissects the scientific underpinnings of 3D bioprinted organs. Part II explores statutory authority and controlling, or otherwise persuasive, case law that pertains to subject-matter patentability. Current rights associated …

In Vitro And In Vivo Characterization Of Potent Antileishmanial Methionine Aminopeptidase 1 Inhibitors, Felipe Rodriguez, Sarah F. John, Eva Iniguez, Sebastian Montalvo, Karina Michael, Lyndsey White, Dong Liang, Omonike A. Olaleye, Rosa A. Maldonado

Faculty Publications

Leishmania major is the causative agent of cutaneous leishmaniasis (CL). No human vaccine is available for CL, and current drug regimens present several drawbacks, such as emerging resistance, severe toxicity, medium effectiveness, and/or high cost. Thus, the need for better treatment options against CL is a priority. In the present study, we validate the enzyme methionine aminopeptidase 1 of L. major (MetAP1Lm), a metalloprotease that catalyzes the removal of N-terminal methionine from peptides and proteins, as a chemotherapeutic target against CL infection. The in vitro antileishmanial activities of eight novel MetAP1 inhibitors (OJT001 to OJT008) were investigated. Three compounds, OJT006, …

Enhancing Global Health Communication During A Crisis: Lessons From The Covid-19 Pandemic, Scott C. Ratzan, Silvia Sommarivac, Lauren Rauh

Publications and Research

Background/objective: The understanding and practice of public health crisis communication are improved through the study of responses to past crises, but require retooling for present challenges. The ‘Addressing Ebola and other outbreaks’ checklist contains guiding principles built upon maxims developed from a World Health Organization consultation in response to the mad cow (bovine spongiform encephalopathy) crisis that were later adopted for Ebola. The purpose of this article is to adapt the checklist for the health communication challenges and public health practices that have emerged during the coronavirus disease 2019 (COVID-19) pandemic. The communication challenges of promoting vaccine acceptance are used …

Fluoroquinolone Versus Nonfluoroquinolone Treatment Of Bloodstream Infections Caused By Chromosomally Mediated Ampc‐Producing Enterobacteriaceae, Sarah Grace Gunter, Katie E. Barber, Jamie L. Wagner, Kayla R. Stover

Faculty and Student Publications

Objectives: Chromosomally mediated AmpC-producing Enterobacteriaceae (CAE) display high susceptibility to fluoroquinolones; minimal clinical data exist supporting comparative clinical outcomes. The objective of this study was to compare treatment outcomes between fluoroquinolone and nonfluoroquinolone definitive therapy of bloodstream infections caused by CAE. Methods: This retrospective cohort assessed adult patients with positive blood cultures for CAE that received inpatient treatment for 48 hours. The primary outcome was difference in clinical failure between patients who received fluoroquinolone (FQ) versus non‐FQ treatment. Secondary endpoints included microbiological cure, infection‐related length of stay, 90‐day readmission, and all‐cause inpatient mortality. Results: 56 patients were included in the …

Mrt Supportive Housing Evaluation: Overall Summary Report, Sandra Mcginnis, Margaret Gullick, Lauren Polvere, Mir Nahid Mahmud, Chris E. Rees

Health and Healthcare Services Reports and Research Briefs

New York has allocated substantial funding from the state’s Medicaid Redesign dollars to provide supportive housing to homeless, unstably housed, and/or other individuals with complex needs, who are high-cost, high-need Medicaid users. It is anticipated that the Medicaid Redesign Team-Supportive Housing initiatives (MRT-SH) will reduce the more expensive forms of health care utilization (e.g., emergency department visits, inpatient hospitalizations, and nursing home stays), potentially reduce overall health care costs, and improve quality of life and health outcomes.

The MRT-SH initiative includes a diverse collection of programs that take a variety of approaches to providing housing and supportive services to different …

Preventing The Corruption Of Healthcare Algorithms, Philip M. Nichols

Notre Dame Journal on Emerging Technologies

The intersection of technology and healthcare will radically change the provision of healthcare services. The full extent of the changes cannot be known now, but the direction is clear: collection of voluminous data and tools powerful enough to analyze that data will facilitate the design of algorithms that will enable machines to make important decisions regarding diagnoses and treatments. In addition to the possible benefits, policymakers and scholars have focused on issues of privacy and potential bias. The potential for corruption of the design of healthcare algorithms has been ignored, but the potential for corruption is real and dangerous. This …

Odei Pathways, Office Of Diversity, Equity, And Inclusion

Newsletters

Practicing Cultural Humility in a Time of Crisis 1-2

Inclusive Teaching Resources 3

Accountability through the Lens of Cultural Humility: A Call to Action 4

Diversity, Equity and Inclusion Council 5

Diversity Grant Awards 6

COVID-19 Crossword Puzzle 7-9

Multiscale Model For Hurricane Evacuation And Fuel Shortage, Sirish Namilae, Dahai Liu, Scott Parr

Center for Advanced Transportation Mobility

Hurricanes are powerful agents of destruction with significant socioeconomic impacts. High-volume mass evacuations, disruptions to the supply chain, and fuel hoarding from non-evacuees have led to localized fuel shortages lasting several days during recent hurricanes. Hurricane Irma in 2017, resulted in the largest evacuation in the nation affecting nearly 6.5 million people and saw widespread fuel shortages throughout the state of Florida. While news reports mention fuel shortages in several past hurricanes, the crowd source platform Gasbuddy has quantified the fuel shortages in the recent hurricanes. The analysis of this fuel shortage data suggested fuel shortages exhibited characteristics of an …