Digital Commons Network^™

Inhibition Of Fatty Acid Oxidation Promotes Macrophage Control Of Mycobacterium Tuberculosis, Pallavi Chandra, Li He, Matthew Zimmerman, Guozhe Yang, Stefan Köster, Mireille Ouimet, Han Wang, Kathyrn J Moore, Véronique Dartois, Joel D Schilling, Jennifer A Philips

Open Access Publications

Macrophage activation involves metabolic reprogramming to support antimicrobial cellular functions. How these metabolic shifts influence the outcome of infection by intracellular pathogens remains incompletely understood.

Pandemic Abandonment, Panoramic Displays And Fascist Propaganda: The Month The Earth Stood Still, Peter Mclaren

Education Faculty Articles and Research

"While governing a country facing a global pandemic, a shattered economy, and widespread civil unrest over the death of George Floyd, Trump has shown little compassion for humanity and has chosen ego gratification over care and concern for his countrymen and in the process put the entire world in greater danger from Covid-19."

Key Strategic Issues List (Ksil) 2021–2022, Steve Cunningham

Books, Monographs & Collaborative Studies

New for Academic Years 2021-2022, the USAWC has published an updated Key Strategic Issues List (KSIL). The KSIL informs students, faculty, and external research associates of strategic topics requiring research and analysis. The USAWC in coordination with Headquarters Department of the Army (HQDA), major commands throughout the Army, and the joint and interagency community has updated the Army's priorities for strategic analysis to address issues in the emerging strategic environment and to align with elements of the current Army Vision and Army Strategy. The USAWC will continue to address select topics as Integrated Research Projects and through other research efforts. …

Cardiac Surgery During The Coronavirus Disease 2019 Pandemic: Perioperative Considerations And Triage Recommendations, Vivek Patel, Ernesto Jimenez, Lorraine Cornwell, Trung Tran, David Paniagua, Ali E Denktas, Andrew Chou, Samuel J Hankins, Biykem Bozkurt, Todd K Rosengart, Hani Jneid

Faculty, Staff and Students Publications

The coronavirus disease 2019 pandemic, caused by severe acute respiratory syndrome coronavirus-2, represents the third human affliction attributed to the highly pathogenic coronavirus in the current century. Because of its highly contagious nature and unprecedented global spread, its aggressive clinical presentation, and the lack of effective treatment, severe acute respiratory syndrome coronavirus-2 infection is causing the loss of thousands of lives and imparting unparalleled strain on healthcare systems around the world. In the current report, we discuss perioperative considerations for patients undergoing cardiac surgery and provide clinicians with recommendations to effectively triage and plan these procedures during the coronavirus disease …

Stop Fighting The Coronavirus, Pranay Sinha

Journal of Wellness

During the COVID-19 pandemic, the refrain of war has echoed across the world. It has tainted the way we speak about the pandemic and shaped the way we think about it. Metaphors can direct thought and action. This essay reflects on the ways in which the metaphor of war is disrupting the way we relate to the pandemic, to our society, and to each other and concludes with an alternative metaphor.

2020-07-06_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

False-Negative Sars-Cov-2 Reverse Transcriptase Polymerase Chain Reaction (Rt-Pcr) Is An Important Consideration For Patient Management And Infection Prevention: A Case Report From The Louisville Covid-19 Epidemiology Study, Matthew Song Pharmd, Bcidp, Ashley M. Wilde, Sarah E. Moore Pharmd, Brian C. Bohn Pharmd, Clayton J. Patross, Bryan Denham, Paul Schulz, Julio A. Ramirez

The University of Louisville Journal of Respiratory Infections

We report a case of false-negative SARS-CoV-2 reverse transcriptase-polymerase chain reaction (RT-PCR) on a nasopharyngeal swab. Treating clinicians and infection preventionists should maintain a high suspicion for COVID-19 in the appropriate clinical setting despite negative test results. Utilization of chest computed tomography (CT) should be strongly considered in the diagnostic work-up for suspected COVID-19, particularly in areas with limited RT-PCR availability.

Concomitant Invasive Pneumococcal Disease In A Patient With Covid-19 – A Case Report From The Louisville Epidemiology Study, Clayton J. Patross, Brian C. Bohn Pharmd, Sarah E. Moore Pharmd, Paul Schulz, Matthew Song Pharmd, Bcidp, Ashley M. Wilde, Julio A. Ramirez

The University of Louisville Journal of Respiratory Infections

A 60-year-old male presented to the emergency department (ED) with a 1–2 day history of confusion, headache, and subjective fever. Because he had met with a contact two days prior to admission who had recently traveled from the Bahamas, a COVID-19 nasopharyngeal (NP) and oropharyngeal (OP) polymerase chain reaction (PCR) test was ordered. He was diagnosed with bacterial meningitis based on presenting neurologic symptoms and the identification of Streptococcus pneumoniae from blood cultures. The COVID-19 NP and OP test returned positive, although he never developed shortness of breath, cough, other respiratory symptoms, diarrhea, abdominal pain, nausea, vomiting, or any change …

Foundational Research And Nih Funding Enabling Emergency Use Authorization Of Remdesivir For Covid-19, Ekaterina Galkina Cleary, Matthew J. Jackson, Zoë Folchman-Wagner, Fred D. Ledley

Natural & Applied Sciences Faculty Publications

Emergency Use Authorization for remdesivir months after discovery of COVID-19 is unprecedented. Typically, decades of research and public-sector funding are required to establish the mature body of foundational research requisite for efficient, targeted drug discovery and development. This work quantifies the body of research related to remdesivir’s biological target, RNA-dependent RNA polymerase (RdRp), or parent chemical structure, nucleoside analogs (NcAn), through 2019, as well as NIH funding for this research 2000–2019. There were 6,567 RdRp-related publications in PubMed, including 1,263 with NIH support, and 11,073 NcAn-related publications, including 2,319 with NIH support. NIH support for RdRp research comprised 2,203 Project …

A Study Of The Efficacy Of Machine Learning For Diagnosing Obstructive Coronary Artery Disease In Non-Diabetic Patients, Demond Larae Handley

Theses and Dissertations

According to the Centers for Disease Control and Prevention, about 18.2 million adults age 20 and older have Coronary Artery Disease in the United States. Early diagnosis is therefore of crucial importance to help prevent debilitating consequences, and principally death for many patients. In this study we use data containing gene expression values from peripheral blood samples in 198 non-diabetic patients, with the goal of developing an age and sex gene expression model for diagnosis of Coronary Artery Disease. We employ machine learning methods to obtain a classification based on genetic information, age and sex. Our implementation uses feed forward …

An Unusual Case Of Campylobacter Jejuni Gastroenteritis Presenting With Acute Reversible Encephalopathy In An Immunocompetent Host, Irma Huayanay, Leonardo Pozo, Salman Bangash, Denisse Ramirez, Luis Rosas, Renzo Arauco Brown

School of Medicine Publications

Campylobacter jejuni gastroenteritis is the most frequent organism associated with acute infectious diarrhea worldwide. (e clinical presentation involves fever, diarrhea, rigors, and myalgias. Other extraintestinal symptoms that have been described involve delirium and other neurological complications, and the most well-known is Guillain-Barr´e, where there is cross-reactivity between the gastrointestinal tract and the brain. Despite previously described multiple neurological complications, there is a lack of clinical data on the association of Campylobacter-related gastroenteritis with acute encephalopathy in immunocompetent patients. (e type of population, immunocompetent stage, and unfamiliarity with the clinical presentation makes this a challenging diagnosis for clinicians. We report a …

Social Patterns And Pathways Of Hiv Care Among Hiv-Positive Transgender Women, Dana D. Hines

Dissertations

Transgender women have the highest HIV prevalence rates of all gender and sexual minorities, yet are less likely to enter and be retained in HIV care. As a result, they are at high risk for HIV-related morbidity and mortality. This study aimed to describe the illness career of transgender women living with HIV and to describe how interactions with health care providers and important others influenced their illness trajectory.

Covid Stress Syndrome: Concept, Structure, And Correlates, Steven Taylor, Caeleigh A. Landry, Michelle M. Paluszek, Thomas A. Fergus, Dean Mckay, Gordon J.G. Asmundsone

Covid-19 Digital Research

Research shows that the COVID Stress Scales have a robust multifactorial structure, representing five correlated facets of COVID‐19‐related distress: (a) Fear of the dangerousness of COVID‐19, which includes fear of coming into contact with fomites potentially contaminated with SARSCoV2, (b) worry about socioeconomic costs of COVID‐19 (e.g., worry about personal finances and disruption in the supply chain), (c) xenophobic fears that foreigners are spreading SARSCoV2, (d) traumatic stress symptoms associated with direct or vicarious traumatic exposure to COVID‐19 (nightmares, intrusive thoughts, or images related to COVID‐19), and (e) COVID‐19‐related compulsive checking and reassurance seeking. These factors cohere to form a …

2020-07-05_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

Managing Icu Surge During The Covid-19 Crisis: Rapid Guidelines(Issue 16, 5 July 2020), S Aziz, Ym Arabi, W Alhazzani, L Evans, G Citerio, K Fischkoff, J Salluh, G Meyfroidt, F Alshamsi, S Oczkowski, E Azoulay, A Price, L Burry, A Dzierba, A Benintende, J Morgan, G Grasselli, A Rhodes, Mh Moller, L Chu, S Schwedhelm, Jj Lowe, D Bin, Md Christian

Covid19 Newsletters

No abstract provided.

Clinical Characteristics And Outcomes Of Patients With H1n1 Influenza Pneumonia Admitted At A Tertiary Care Hospital In Karachi, Pakistan, Mujahid Hussain, Nosheen Nasir, Muhammad Irfan, Zahra Hasan

Section of Pulmonary & Critical Care

Introduction: Influenza viruses specifically, A and B mainly contribute to seasonal outbreaks that occur globally. However, due to limited diagnostics for influenza there is little data regarding clinical outcomes of patients with H1N1 pneumonia in our region. Our objective was to determine the clinical characteristics and outcomes of patients hospitalized with H1N1 pneumonia at a tertiary care facility in Karachi, Pakistan.
Methods: A retrospective study of adult patients admitted with influenza pneumonia from November 2017 to February 2018 at a tertiary care hospital in Karachi, Pakistan. Patient characteristics were compared between influenza A H1N1 and other types of influenza using …

Pathomorphology Of Lymphatic Nodes During Neonatal Sepsis, Dilshod Sh. Allaberganov, Radjab I. Israilov, Nargiza I. Tajimova

Central Asian Journal of Medicine

Background. Morphofunctional state of newborn immunity organs, in particular lymph nodes, during sepsis has not been well-studied so far. This research was dedicated to study the morphological and morphometric features of the lymph nodes of infants who died in the neonatal period because of sepsis. Methodology. The research materials were samples of paratracheal and mesenteric lymph nodes which were taken from 42 neonatal infants’ autopsy specimens. Morphological, histochemical and morphometric methods were used to study lymph node samples obtained from different localizations. Morphometric analysis was applied to evaluate the lymph node diameter, cortex (B-zone) width, paracortical T-zone as well as …

Influence Of Trachea Stenosis On Functioning Of Poly-Enzy Membrane Mitochondria Liver Systems, Bozorbay Buzrukkhodjayevich Polvanov, Navruz Noryigitovich Djabborov, Almatov Karim Tajibayevich

Central Asian Journal of Medicine

The aim. A comparative study of activity of multienzyme systems of respiratory chain of mitochondria of liver, which have different sensitivity to hypoxia in conditions of moderate tracheal stenosis. Material and methods. 50 outbred rabbits weighing 2.3-2.5kg were used. Stenosis was created by applying a wide silk ribbon to trachea and narrowing the lumen from 1/3 to 2/3 [8]. Degree of narrowing was determined directly during slaughter of animals, as well as by the nature of the spirogram, clinical signs and by measuring the lumen of stenotic section of trachea relative to original using tracheoscopy. Rabbits were killed by decapitation …

The Role Of Extragenital Diseases In The Structure Of Maternal Mortality, I.M. Allanazarov

Central Asian Journal of Medicine

In this paper, was analyzed the data of scientific research on the importance of extragenital diseases in the structure of maternal mortality. In the civilized world’s countries, extragenital diseases occupy the first place among the causes of maternal mortality. According to the WHO and many scientists, among the deceased women in childbirth and puerperas, 37.9% died of extragenital pathology, of which 35.3% were respiratory diseases, 14.1% - diseases of the circulatory system, 7.0% - injuries and poisoning, 3, 5% - neoplasms, 2.4% each - some infectious diseases, congenital anomalies; 1.2% each - diseases of the nervous system, digestive organs, musculoskeletal …

2020-07-03_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

Isotype-Specific Outcomes In Fc Gamma Receptor Targeting Of Pspa Using Fusion Proteins As A Vaccination Strategy Against Streptococcus Pneumoniae Infection, Kari Wiedinger

Seton Hall University Dissertations and Theses (ETDs)

Streptococcus pneumoniae (Spn) remains a considerable threat to public health despite the availability of antibiotics and polysaccharide conjugate vaccines. The lack of mucosal immunity in addition to capsular polysaccharide diversity, has proved to be problematic in developing a universal vaccine against Spn. Targeting antigen to Fc receptors is an attractive way to augment both innate and adaptive immunity against mucosal pathogens, by promoting interactions with activating Fcγ receptors (FcγR) that mediate diverse immunomodulatory functions. The effect of targeting FcγR is highly influenced by the IgG subclass, which bares differential affinities for activating and inhibitory FcγR. In the current study we …

Alma Link Resolver Title & Issn Report (Top 500) 2019-2020, Andrée J. Rathemacher

Technical Services Reports and Statistics

Statistics for 2019-2020 on the total number of OpenURL requests by journal title and ISSN made to the Ex Libris Alma link resolver for items held by the University of Rhode Island Libraries. Includes only the top 500 journals.

Information provided includes journal Title, ISSN, EISSN, Number of Requests, Number of Clicked Requests, % Clicks from Requests.

Regulated And Hydrated: A Case For Regulating Bottled Water, Ford-Stille, Hannah

Santa Clara Law Review

REGULATED AND HYDRATED: A CASE FOR REGULATING BOTTLED WATER

Preservation Of Latest Cretaceous (Maastrichtian) - Paleocene Frogs (Eorubeta Nevadensis) Of The Sheep Pass Formation Of East-Central Nevada And Implications For Paleogeography Of The Nevadaplano, Joshua W. Bonde, Peter A. Druschke, Richard P. Hilton, Amy C. Henrici, Stephen M. Rowland

Geoscience Faculty Research

Here we report on exceptional preservation of remains of the frog Eorubeta nevadensis in deposits of the Sheep Pass Formation, ranging from Late Cretaceous to Eocene, in the south Egan Range, Nevada. This formation represents a lacustrine basin within the Sevier retroarc hinterland. The formation is subdivided into six members (A–F); of interest here are members B and C. The base of member B is ?uppermost Cretaceous-Paleocene, while member C is Paleocene. Member B frogs are preserved in three taphonomic modes. Mode 1 frogs are nearly complete and accumulated under attritional processes, with frogs settling on microbial mats, as evidenced …

Covid-19 And Stroke In Sub-Saharan Africa: Case Series From Dar Es Salaam, Philip Adebayo, Nadeem Kassam, Omar Aziz, Ahmed Jusabani, Samina Somji, Mugisha Clement

Internal Medicine, East Africa

Low and middle-income countries including those in sub-Saharan (SSA) Africa are experiencing a steady increase in the number of COVID-19 cases. To the best of our knowledge, reports of COVID-19 related strokes are scarce in SSA. The peculiar situation of stroke care in SSA makes COVID-19 associated stroke a bothersome entity as it adds other dynamics that tilt the prognostic balance. We present a case series of COVID -19 related stroke in 3 patients from Tanzania. We emphasized protected code stroke protocol.

Organizational Change In The Sphere Of Health Protection Of The Roma Community In Poland Seen From Different Perspectives, Marleen Blom, Izabella Łęcka

European Management Studies

Purpose: The intent of this study is to get insight into the different views on Roma health in Poland to improve health, access to healthcare and broaden the understanding of the limitations for the Roma inclusion in the mainstream of organizational behaviour of health and well-being institutions. Design/methodology/approach: The lack of institutional success up to date in the conduct of policies supporting the Roma on the path to an even standard of living, including health, suggests seeking new organizational approaches. To find the answers to these questions “What views do the Roma/Roma experts/Polish society have on Roma health?” qualitative research …

Immune Function During Pregnancy Varies Between Ecologically Distinct Populations, Carmen Hové, Benjamin C. Trumble, Amy S. Anderson, Jonathan Stieglitz, Hillard Kaplan, Michael Gurven, Aaron Blackwell

ESI Publications

Background and objectives

Among placental mammals, females undergo immunological shifts during pregnancy to accommodate the fetus (i.e. fetal tolerance). Fetal tolerance has primarily been characterized within post-industrial populations experiencing evolutionarily novel conditions (e.g. reduced pathogen exposure), which may shape maternal response to fetal antigens. This study investigates how ecological conditions affect maternal immune status during pregnancy by comparing the direction and magnitude of immunological changes associated with each trimester among the Tsimane (a subsistence population subjected to high pathogen load) and women in the USA.

Methodology

Data from the Tsimane Health and Life History Project (N = 935) and …

Adapting A Teaching Hospital To A Covid Environment

Jefferson Surgical Solutions

The last ten days have been unlike any other we have known. People throughout the world are acting to slow the spread of a dangerous virus that threatens to strain the capacity of our hospitals and our caregivers; and its effects have already deeply impacted normal day to day life. I ask for your support and forbearance during this difficult time.

Charles J. Yeo, MD, FACS, Enterprise Chair of Surgery, shared those words in a letter to the Department of Surgery on March 19, 2020. In the days and weeks following, the Department came together to meet the unprecedented challenges …

Meta-Analysis Of Outcomes Of Patients With Covid-19 Infection With Versus Without Gastrointestinal Symptoms., Fahad Gul, Kevin Bryan Lo, Julie Peterson, Peter A Mccullough, Abhinav Goyal, Janani Rangaswami

COVID-19 Papers, Posters, and Presentations

This systematic review analyzed whether the presence or absence of gastrointestinal symptoms in patients with SARS-COV-2 infection is associated with adverse outcomes. Searching the Cochrane Center Register of Controlled Trials, we included any studies looking at patients with COVID-19 with gastrointestinal symptoms (nausea, vomiting, diarrhea, abdominal pain) compared to those with COVID-19 but without gastrointestinal manifestations as a control group. The final search yielded 186 articles, all of which were individually screened. Seven studies were identified but three were excluded: one due to lack of a control group without gastrointestinal symptoms, one reported as viral RNA in the stool, and …

Trichosporon Species And Fusarium Species As A Cause Of Empyema Thoracis In A Diabetic Patient, Nousheen Iqbal, Muhammad Ammar, Muhammad Irfan, Kauser Jabeen

Section of Pulmonary & Critical Care

Of late, fungal infections are increasingly being recognized in diabetic patients. Here we present a case of polymicrobial fungal empyema due to Trichosporon species and Fusarium species developed after community-acquired pneumonia in a diabetic patient. Trichosporon species are basidiomycetous yeast and Fusarium species are soil saprophytes with a worldwide distribution. Fungal empyema cases are rare and are mostly caused by Aspergillus and Candida species. Polymicrobial fungal empyema with Trichosporon species and Fusarium species has not been reported previously. Our patient was successfully treated with antifungal therapy. This case highlights that fungal empyema should be considered in diabetic patients especially if …