Digital Commons Network^™

Wild Poliovirus Type 1 In Oman: A Re-Emerging Threat That Requires Urgent, Targeted And Strategic Preparedness, Salah T. Al Awaidy, Faryal Khamis

Sultan Qaboos University Medical Journal

No abstract provided.

Possibility For Reverse Zoonotic Transmission Of Sars-Cov-2 To Free-Ranging Wildlife: A Case Study Of Bats, Kevin J. Olival, Paul M. Cryan, Brian R. Amman, Ralph S. Baric, David S. Blehert, Cara E. Brook, Charles H. Calisher, Kevin T. Castle, Jeremy T. H. Coleman, Peter Daszak, Jonathan H. Epstein, Hume Field, Winifred F. Frick, Amy T. Gilbert, David T. S. Hayman, Hon S. Ip, William B. Karesh, Christine K. Johnson, Rebekah C. Kading, Tigga Kingston, Jeffrey M. Lorch, Ian H. Mendenhall, Alison J. Peel, Kendra L. Phelps, Raina K. Plowright, Deeann M. Reeder, Jonathan D. Reichard, Jonathan M. Sleeman, Daniel G. Streicker, Jonathan S. Towner, Lin-Fa Wang

KIP Articles

No abstract provided.

Synthesis Of Biologically Active Phosphorus Heterocycles, Giri Gnawali

Dissertations

This dissertation work is divided into two parts. The first part is focused in the development of methodology for the synthesis of phostones and phosphonosugars and advancement thereof. The second part is focused in the development of affinity probes based on analogs of natural products cyclophostin and the cyclipostins.

Phostone (3) and phosphonosugars are cyclic phosphonates. The anomeric carbon of sugar is replaced by a phosphorus atom. The synthesis of phostones has been achieved starting form the key intermediate, γ,δ-epoxy vinyl phosphonate (1). The palladium catalyzed ring opening of γ,δ-epoxy vinyl phosphonates by a nucleophile results …

New Addiction And Pain Prevention Center Aims To Rally Researchers And Community, Staff

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No abstract provided.

Uab Receives Idsa Antimicrobial Stewardship Centers Of Excellence Designation, Alicia Rohan

Browse All News

No abstract provided.

The Effect Of Ultraviolet C Radiation Against Different N95 Respirators Inoculated With Sars-Cov-2, David M Ozog, Jonathan Z. Sexton, Shanthi Narla, Carla D. Pretto-Kernahan, Carmen Mirabelli, Henry W. Lim, Iltefat H. Hamzavi, Robert J. Tibbetts, Qing-Sheng Mi

Dermatology Articles

OBJECTIVES: There are currently no studies that have examined whether one dosage can be uniformly applied to different respirator types to effectively decontaminate SARS-CoV-2 on N95 filtering facepiece respirators (FFRs). Health care workers have been using this disinfection method during the pandemic. Our objective was to determine the effect of UVC on SARS-CoV-2 inoculated N95 respirators and whether this was respirator material/model type dependent.

METHODS: Four different locations (facepiece and strap) on five different N95 FFR models (3M 1860, 8210, 8511, 9211; Moldex 1511) were inoculated with a 10 μL drop of SARS-CoV-2 viral stock (8 × 10

RESULTS: UVC …

Needle Stick And Sharp Injuries Among Healthcare Workers: A Retrospective Six-Year Study, Rami Saadeh, Khaled Khairallah, Hussein Abozeid, Lama Al Rashdan, Mahmoud Alfaqih, Obaidallah Alkhatatbeh

Sultan Qaboos University Medical Journal

Objectives: This study aimed to examine the proportion of needle stick and sharp injuries (NSSIs) among healthcare workers at King Hussein Medical Center (KHMC), Amman, Jordan. Methods: All NSSI reports referred from departments at KHMC to the Preventive Medicine Department between 2013–2018 were retrospectively reviewed. Proportion of NSSIs were calculated and stratified according to age, gender, job title, place and site of injury and the procedure/task during which the injury occurred. Results: There were a total of 393 NSSIs. A significant association was found between the proportion of NSSIs and all tested variables (P <0.001). The reported proportion of NSSIs was highest among nurses (39.7%) followed by cleaners (36.3%), physicians (10.4%), other workers (7.4%) and lab technicians (5.9%) during the study’s six-year period. Hospital wards were the most common locations (46.1%) where injuries took place. Injuries also occurred most frequently during medical waste collection (38.2%). Conclusion: The proportion of NSSIs was highest among nurses and cleaners. Safety policies and training among high-risk groups should be reviewed to reduce the risk of NSSIs. Multicentre studies at a national level should be conducted to examine whether this study’s findings reflect national trends.

September 2020 Faculty Senate Packet, University Of Nebraska At Kearney Faculty Senate

Faculty Senate Packets

No abstract provided.

Current Challenges Of Digital Health Interventions In Pakistan: Mixed Methods Analysis, Abdul Momin Kazi, Saad Ahmed Qazi, Nazia Ahsan, Sadori Khawaja, Fareeha Sameen, Muhammad Ayub Khan Mughal, Zabin Wajidali, Hussain Kalimuddin, Yasir Rauf, Fatima Mahmood

Department of Paediatrics and Child Health

Background: Digital health is well-positioned in low and middle-income countries (LMICs) to revolutionize health care due, in part, to increasing mobile phone access and internet connectivity. This paper evaluates the underlying factors that can potentially facilitate or hinder the progress of digital health in Pakistan.
Objective: The objective of this study is to identify the current digital health projects and studies being carried out in Pakistan, as well as the key stakeholders involved in these initiatives. We aim to follow a mixed-methods strategy and to evaluate these projects and studies through a strengths, weaknesses, opportunities, and threats (SWOT) analysis to …

Lipocalin-2 Deficiency May Predispose To The Progression Of Spontaneous Age-Related Adiposity In Mice, Keya Meyers, María López, Joanna Ho, Savannah Wills, Srujana Rayalam, Shashidharamurthy Taval

PCOM Scholarly Works

Lipocalin-2 (Lcn2) is an innate immune protein elevated by several orders of magnitude in various inflammatory conditions including aging and obesity. Recent studies have shown that Lcn2 is secreted by adipocytes in response to inflammation and is categorized as a new adipokine cross-linking innate immunity and metabolic disorders including obesity. However, the involvement of Lcn2 and its function during the progression of obesity is largely unknown. Recently, browning of white adipose tissue (WAT) has gained attention as a therapeutic strategy to combat obesity. Herein, we have shown that treatment of mature 3T3-L1 adipocytes with recombinant Lcn2 (rec-Lcn2) resulted in the …

Severe Immunosuppression And Not A Cytokine Storm Characterizes Covid-19 Infections, Kenneth E Remy, Monty Mazer, David A Striker, Ali H Ellebedy, Andrew H Walton, Jacqueline Unsinger, Teresa M Blood, Philip A Mudd, Daehan J Yi, Daniel A Mannion, Dale F Osborne, R Scott Martin, Nitin J Anand, James P Bosanquet, Jane Blood, Anne M Drewry, Charles C Caldwell, Isaiah R Turnbull, Scott C Brakenridge, Lyle L Moldwawer, Richard S Hotchkiss

Open Access Publications

COVID-19-associated morbidity and mortality have been attributed to a pathologic host response. Two divergent hypotheses have been proposed: hyperinflammatory cytokine storm; and failure of host protective immunity that results in unrestrained viral dissemination and organ injury. A key explanation for the inability to address this controversy has been the lack of diagnostic tools to evaluate immune function in COVID-19 infections. ELISpot, a highly sensitive, functional immunoassay, was employed in 27 patients with COVID-19, 51 patients with sepsis, 18 critically ill nonseptic (CINS) patients, and 27 healthy control volunteers to evaluate adaptive and innate immune status by quantitating T cell IFN-ɣ …

Interventions In Measles Outbreaks: The Potential Reduction In Cases Associated With School Suspension And Vaccination Interventions, David R. Sinclair, John J. Grefenstette, Mary G. Krauland, David D. Galloway, Robert J. Frankeny, Clayton Travis, Donald S. Burke, Steven M. Albert, Mark S. Roberts

Journal of Applied Research on Children: Informing Policy for Children at Risk

Background: Measles is resurgent in the US, with more cases in 2019 than any year since 1992. Many of the cases were concentrated in three outbreaks in New York and Washington states, where local governments enacted intervention strategies in an attempt to limit the spread of measles. Regulations differed by location, suggesting guidance on the optimal interventions may be beneficial.

Methods: We simulate the daily interactions of the populations of six metropolitan areas of Texas, US, using an agent-based model. The real-life vaccination rates of each school in these metropolitan areas are applied to simulated equivalents. A single case of …

Secure Digital Contact Tracing Methods Are Necessary For Slowing Down Covid-19, Rania Ansari

Pop Culture Intersections

This article covers the fears of digital contact tracing during the current pandemic. Citizens do have the right to be understandably uncertain about trusting the government because of past instances such as security breaches ranging from NSA security leaks to personal voter data exposure. The information provided in this paper should, additionally, make it easier for those who are worried about contact tracing and their rights to understand what is implied by the phrases “digital contact tracing” and “data privacy.” The novel coronavirus pandemic calls for urgent, necessary, and effective safety methods, including data analytics, surveillance, and Artificial Intelligence that …

New Studies Test Convalescent Plasma For Covid-19 Treatment - And Prevention, Matt Windsor

Browse All News

No abstract provided.

Covid-19 Update For The University Of Mississippi Community, September 02, 2020, University Of Mississippi

COVID-19 Emails

No abstract provided.

A Call For Action To Safely Deliver Oral Health Care During And Post Covid-19 Pandemic, Marco Farronato, Santosh K. Tadakamadla, Mir Faeq Ali Quadri, Shashidhar Acharya

Open Access archive

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak started just a couple of months ago and it grew rapidly causing several deaths and morbidities. The mechanism behind the transmission of the virus is still not completely understood despite a multitude of new specific manuscripts being published daily. This article highlights the oral cavity as a possible viral transmission route into the body via the Angiotensin converting enzyme 2 receptor. It also provides guidelines for routine protective measures in the dental office while delivering oral health care.

Daily Digest - Wednesday, September 2, 2020 Covid-19 Updates, University Of Mississippi

COVID-19 Website Archives

Campus Update Daily Digest for Wednesday, September 2, 2020

Clinical Trial Will Test Possible Covid-19 Treatment For Outpatients, Jeff Hansen

Browse All News

No abstract provided.

Immune-Related Gene Expression And Cytokine Secretion Is Reduced Among African American Colon Cancer Patients, Jenny Paredes, Jovanny Zabaleta, Jone Garai, Ping Ji, Sayed Imtiaz, Marzia Spagnardi, Joussette Alvarado, Li Li, Mubarak Akadri, Kaylene Barrera, Maria Munoz-Sagastibelza, Raavi Gupta, Mohamed Alshal, Maksim Agaronov, Henry Talus, Xuefeng Wang, John M. Carethers, Jennie L. Williams, Laura A. Martello

School of Medicine Faculty Publications

Background: Colorectal cancer is the third most deadly cancer among African Americans (AA). When compared to Caucasian Americans (CA), AA present with more advanced disease and lower survival rates. Here, we investigated if differences in tumor immunology could be contributive to disparities observed between these populations. Methods: We examined gene expression of tumor and non-tumor adjacent tissues from AA and CA by whole transcriptome sequencing, and generated scores for immune cell populations by NanoString. In addition, we utilized “The Cancer Genome Atlas” (TCGA) database from AA and CA as a validation cohort. Finally, we measured the secretion of cytokines characteristic …

Are Pangolins Scapegoats Of The Covid-19 Outbreak-Cov Transmission And Pathology Evidence?, Siew Woh Choo, Jinfeng Zhou, Xuechen Tian, Siyuan Zhang, Shen Qiang, Stephen James O'Brien, Ka Yun Tan, Sara Platto, Klaus-Peter Koepfli, Agostinho Antunes, Frankie Thomas Sitam

Biology Faculty Articles

The COVID‐19 outbreak has infected over 6 million people across the world. The origin of COVID‐19 coronavirus (CoV) remains unknown, although pangolins have been suggested as potential hosts. We investigated two pangolins seized in Guangdong Province, China. Molecular screening revealed CoV in one pangolin (“Dahu”), while another (“Meidong”) was infected by Ehrlichia ruminantium. Dahu exhibited difficulty breathing, infections of lung, intestines, and nostrils, as revealed by computed tomography imaging and necropsy. Previous phylogenetic analyses showed bat coronavirus RaTG13 is closer to COVID‐19 CoV compared to pangolin coronavirus. Over 20 caregivers have had close physical contact with CoV‐positive Dahu, but …

Understanding The Impact Of Social Distancing On Older Adults And Senior Centers To Better Adapt Towards A New Normal, Salina Jivan

Student Capstone Papers

COVID-19 brought about social distancing mandates that posed as a new barrier to meaningful social participation in the community. The purpose of this project was to understand the impact of social distancing on older adults and senior organizations to better inform the role of OT in helping seniors adapt towards a new normal within the community. A qualitative study and needs assessment were performed through phone interviews with seniors and organizations that support them from around the United States. Themes highlighted seniors desire for social contact and cautious return to the community once mandates are lifted. Both seniors and organizations …

Evidence For Height And Immune Function Trade-Offs Among Preadolescents In A High Pathogen Population, Angela R. Garcia, Aaron Blackwell, Benjamin C. Trumble, Jonathan Stieglitz, Hillard Kaplan, Michael Gurven

ESI Publications

Background

In an energy-limited environment, caloric investments in one characteristic should trade-off with investments in other characteristics. In high pathogen ecologies, biasing energy allocation towards immune function over growth would be predicted, given strong selective pressures against early-life mortality.

Methodology

In the present study, we use flow cytometry to examine trade-offs between adaptive immune function (T cell subsets, B cells), innate immune function (natural killer cells), adaptive to innate ratio and height-for-age z scores (HAZ) among young children (N = 344; aged 2 months–8 years) in the Bolivian Amazon, using maternal BMI and child weight-for-height z scores (WHZ) as …

Carrying The Nation On Fragile Shoulders: Female Textile Workers In A Modernizing Japan, Max R. Bouchard

The Gettysburg Historical Journal

During the period from the early Meiji era to the end of the Second World War in which Imperial Japan sought to modernize the nation’s economy by investing heavily in mechanized labor industries, cotton and silk textile manufacturing was the lead sector in this industrialization process. One of the most distinctive features of this vitally important industry was that Japanese women, mostly of relatively young ages and from rural communities across the country, constituted the majority of the workers employed in textile factories. Throughout this era, the treatment of this predominantly female workforce on the part of both textile companies …

Gettysburg Historical Journal 2020

The Gettysburg Historical Journal

Complete Issue of the Gettysburg Historical Journal 2020

Assessment Of Prescribing Pattern Of Antimicrobials Among Paediatric Inpatients Of Tertiary Care Teaching Hospital, Shiv Kumar, Amal Balakrishnakurup Kovattu, Jintu John, Bhavesh Akbari

Manipal Journal of Pharmaceutical Sciences

No abstract provided.

Development Trends Of Health Capital In Uzbekistan: Problems And Realities, G.U. Shamiev

Economics and Innovative Technologies

The article presents the issues of health capital formation as a component of human capital, analyzed the trends of its development, identified its main features, as well as the factors which influencing to its formation. Analyzed the main indicators which are reflecting to the health capital in Uzbekistan. Based on the analysis of qualitative and quantitative parameters, a conclusion was made on the formation of health capital, which will contribute to the further economic development of the country.

Development Trends Of Health Capital In Uzbekistan: Problems And Realities, G.U. Shamiev

Economics and Innovative Technologies

The article presents the issues of health capital formation as a component of human capital, analyzed the trends of its development, identified its main features, as well as the factors which influencing to its formation. Analyzed the main indicators which are reflecting to the health capital in Uzbekistan. Based on the analysis of qualitative and quantitative parameters, a conclusion was made on the formation of health capital, which will contribute to the further economic development of the country.

Covid-19 And The Environment: Reflections On The Pandemic In Asia, Hao Huang

EnviroLab Asia

The idea of planetary health as a form of scholarly analysis and scientific investigation has particular relevance to the COVID-19 pandemic and to Asia, where the outbreak of the novel coronavirus was first reported. Over the past three decades, the continent’s rapid urbanization and industrialization have played a significant role in the region’s economic growth, increase in per capita income and the concentration of wealth, and the creation of some of the world’s fast-growing cities. These profound benefits have come with some serious consequences, however, and planetary-health experts have stressed that one of them has been the sharp uptick in …

Reaching Consensus On A Home Infusion Central Line-Associated Bloodstream Infection Surveillance Definition Via A Modified Delphi Approach., Sara Keller, Alejandra Salinas, Deborah Williams, Mary Mcgoldrick, Lisa Gorski, Mary Alexander, Anne Norris, Jennifer Charron, R. Scott Stienecker Md, Catherine Passaretti, Lisa Maragakis, Sara E Cosgrove

Infection Control

BACKGROUND: A consensus on a central line-associated bloodstream infection (CLABSI) surveillance definition in home infusion is needed to standardize measurement and benchmark CLABSI to provide data to drive improvement initiatives METHODS: Experts across fields including home infusion therapy, infectious diseases, and healthcare epidemiology convened to perform a 3-step modified Delphi approach to obtain input and achieve consensus on a candidate home infusion CLABSI definition.

RESULTS: The numerator criterion was identified by participants as involving one of the 2 following: (1) recognized pathogen isolated from blood culture and pathogen is not related to infection at another site, or (2) one of …

Campus Assembly Minutes 09/01/2020, Campus Assembly

Campus Assembly

No abstract provided.