Digital Commons Network^™

Thermoneutrality Alters Gastrointestinal Antigen Passage Patterning And Predisposes To Oral Antigen Sensitization In Mice, Taeko K Noah, Jee-Boong Lee, Christopher A Brown, Amnah Yamani, Sunil Tomar, Varsha Ganesan, Rodney D Newberry, Gary B Huffnagle, Senad Divanovic, Simon P Hogan

Open Access Publications

Food allergy is an emerging epidemic, and the underlying mechanisms are not well defined partly due to the lack of robust adjuvant free experimental models of dietary antigen sensitization. As housing mice at thermoneutrality (Tn) - the temperature of metabolic homeostasis (26-30°C) - has been shown to improve modeling various human diseases involved in inflammation, we tested the impact of Tn housing on an experimental model of food sensitization. Here we demonstrate that WT BALB/c mice housed under standard temperature (18-20°C, Ts) conditions translocated the luminal antigens in the small intestine (SI) across the epithelium

Acute Symptoms Of Mild To Moderate Covid-19 Are Highly Heterogeneous Across Individuals And Over Time, Thomas L. Rodebaugh, Madelyn R. Frumkin, Angela M. Reiersen, Eric J. Lenze, Michael S. Avidan, J. Philip Miller, Jay F. Piccirillo, Charles F. Zorumski, Caline Mattar

Open Access Publications

Background: The symptoms of coronavirus disease 2019 (COVID-19) appear to be heterogenous, and the typical course of these symptoms is unknown. Our objectives were to characterize the common trajectories of COVID-19 symptoms and to assess how symptom course predicts other symptom changes as well as clinical deterioration.

Methods: One hundred sixty-two participants with acute COVID-19 responded to surveys up to 31 times for up to 17 days. Several statistical methods were used to characterize the temporal dynamics of these symptoms. Because 9 participants showed clinical deterioration, we explored whether these participants showed any differences in symptom profiles.

Results: Trajectories varied …

Whipworm-Associated Intestinal Microbiome Members Consistent Across Both Human And Mouse Hosts, Bruce A Rosa, Caroline Snowden, John Martin, Kerstin Fischer, Jonah Kupritz, Ethiopia Beshah, Taniawati Supali, Lincoln Gankpala, Peter U Fischer, Joseph F Urban, Makedonka Mitreva

Open Access Publications

The human whipworm

Bromodomain Protein Brd4 Directs And Sustains Cd8 T Cell Differentiation During Infection, J. Justin Milner, Takeshi Egawa, Et Al

Open Access Publications

In response to infection, pathogen-specific CD8 T cells differentiate into functionally diverse effector and memory T cell populations critical for resolving disease and providing durable immunity. Through small-molecule inhibition, RNAi studies, and induced genetic deletion, we reveal an essential role for the chromatin modifier and BET family member BRD4 in supporting the differentiation and maintenance of terminally fated effector CD8 T cells during infection. BRD4 bound diverse regulatory regions critical to effector T cell differentiation and controlled transcriptional activity of terminal effector-specific super-enhancers in vivo. Consequentially, induced deletion of Brd4 or small molecule-mediated BET inhibition impaired maintenance of a terminal …

Overlapping But Disparate Inflammatory And Immunosuppressive Responses To Sars-Cov-2 And Bacterial Sepsis: An Immunological Time Course Analysis, Tyler J Loftus, Ricardo Ungaro, Marvin Dirain, Philip A Efron, Monty B Mazer, Kenneth E Remy, Richard S Hotchkiss, Luer Zhong, Rhonda Bacher, Petr Starostik, Lyle L Moldawer, Scott C Brakenridge

Open Access Publications

Both severe SARS-CoV-2 infections and bacterial sepsis exhibit an immunological dyscrasia and propensity for secondary infections. The nature of the immunological dyscrasias for these differing etiologies and their time course remain unclear. In this study, thirty hospitalized patients with SARS-CoV-2 infection were compared with ten critically ill patients with bacterial sepsis over 21 days, as well as ten healthy control subjects. Blood was sampled between days 1 and 21 after admission for targeted plasma biomarker analysis, cellular phenotyping, and leukocyte functional analysis

Identifying The Impact Of Intimate Partner Violence In Humanitarian Settings: Using An Ecological Framework To Review 15 Years Of Evidence, Melissa Meinhart, Ilana Seff, Katrina Troy, Samantha Mcnelly, Luissa Vahedi, Catherine Poulton, Lindsay Stark

Open Access Publications

Intimate partner violence (IPV) is a pervasive form of gender-based violence that exacerbates in humanitarian settings. This systematic review examined the myriad IPV impacts and the quality of existing evidence of IPV in humanitarian settings. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) procedures, a total of 51 articles were included from the 3924 screened. We identified the impact of IPV across two levels of the ecological framework: individual and microsystem. Our findings corroborated previous evidence that indicated IPV to be associated with adverse physical and mental health for survivors. Our findings also uniquely synthesized the intergenerational …

Taxonomic Changes In The Gut Microbiota Are Associated With Cartilage Damage Independent Of Adiposity, High Fat Diet, And Joint Injury, Kelsey H. Collins, Drew J. Schwartz, Kristin L. Lenz, Charles A. Harris, Farshid Guilak

Open Access Publications

No abstract provided.

Preliminary, Real-World, Multicenter Experience With Omadacycline For Mycobacterium Abscessus Infections, Taylor Morrisette, Sara Alosaimy, Julie V. Philley, Carly Wadle, Catessa Howard, Andrew J. Webb, Michael P. Veve, Melissa L. Barger, Jeannette Bouchard, Tristan W. Gore, Abdalhamid M. Lagnf, Iman Ansari, Carlos Mejia-Chew, Keira A. Cohen, Michael J. Rybak

Open Access Publications

Twelve patients were treated with omadacycline (OMC) as part of a multidrug regimen for

Using Lorenz Curves To Measure Racial Inequities In Covid-19 Testing, Aaloke Mody, Kristin Pfeifauf, Elvin H. Geng

Open Access Publications

No abstract provided.

Design Of A Virtual Cybersecurity Escape Room, Tania Williams, Omar F. El-Gayar

Research & Publications

As cybersecurity education and training methods endeavor to build a skilled workforce to meet the growing demands of government and industry, it is important to craft training exercises to build and assess a learner’s understanding of cybersecurity topics in a fun and meaningful way. To meet this need, we designed a concept map and virtual model of a collaborative, virtual cybersecurity escape room. Escape rooms, which are a form of serious games intended to increase knowledge and skills or measure learning outcomes, are scenario-based and interactive in nature. The artifacts described align the serious gaming elements with elements associated with …

(Un)Masking The Truth - The Cruel And Unusual Punishment Of Prisoners Amidst The Covid-19 Pandemic, Ariel Berkowitz

Touro Law Review

No abstract provided.

Health Literacy Of University Students In Covid-19 Pandemic And Infodemic: A Pakistani Perspective, Rozeen Shaukat, Muhammad Asif Naveed

Library Philosophy and Practice (e-journal)

This research investigated the levels of health literacy among Pakistani university students in the Covid-19 pandemic and infodemic. The university students were surveyed using an online questionnaire at two public sector universities and one private sector university in Punjab-Pakistan. The administration of the data collection instrument was completed with permission from concerned authorities. A total of 374 responses received which were imported to SPSS and analyzed by applying descriptive as well as inferential statistics. The results revealed that the health literacy of university students in the Covid-19 pandemic and infodemic was not at an optimal level as these participants expressed …

An Investigation Of The Role Of Basigin-Variant-1 In The Immune Response Within The Retina, Abigail D. Tompa

UNF Graduate Theses and Dissertations

The neural retina is considered an immune privileged area, in that the eye attempts to suppress the inflammatory response to preserve vision. If there is damage to the blood-retina barrier, such as in diabetes or macular degeneration, it is possible for monocytes to travel out of the blood vessels and into the retina. While studying retinoblastoma, a research group determined that the protein, Basigin, through its extracellular domain, elicits an immune response by enhancing transcription of the pro-inflammatory cytokine interleukin-6 (IL-6). Basigin is cell adhesion molecule that belongs to the immunoglobulin superfamily. The Basigin gene has two main transcripts, that …

The Impact Of Rurality, Underlying Cardiovascular Disease, And Socioeconomic Vulnerability On Covid-19 Outcomes In Georgia, Michael C. Morgan, Lavannya Atri, Jennifer L. Waller, Douglas Miller, Adam E. Berman

Journal of the Georgia Public Health Association

Background: COVID-19 related illnesses have been associated with an increased prevalence of cardiovascular disease sequelae and worsened socioeconomic variables. We sought to investigate the relationship between COVID-19 outcomes, underlying cardiovascular disease, and socioeconomic determinants of health in rural and non-rural counties in the state of Georgia.

Methods: COVID-19, demographic, and socioeconomic data were acquired from publicly available databases including the Center for Disease Control and Prevention’s Social Vulnerability Index (SVI). The relationship between COVID-19 outcomes and markers of cardiovascular disease burden, rurality, and socioeconomic determinants of health was assessed at the county level in Georgia through the beginning of …

Campus Recreation And Fitness Center Utilization During The Covid-19 Pandemic, Keagan Kiely, William A. Mase, Bridget F. Melton, Haresh Rochani

Journal of the Georgia Public Health Association

Background

The impact of the COVID-19 pandemic has far reaching effects for college students' health and physical activity behaviors. This analysis focuses on university student fitness center usage pre and during the COVID-19 pandemic. Researchers hypothesized a reduction in fitness center utilization when comparing Fall 2019 to Fall 2020 utilization rates.

Methods

Patterns of the recreation center and fitness center utilization during the COVID-19 pandemic are compared to pre-pandemic patterns of a matched time period in the previous academic year in an observational study. Overall utilization was evaluated using secondary data from the university’s recreation center data system. Six weeks …

The Interplay Of Policy, Behavior, And Socioeconomic Conditions In Early Covid-19 Epidemiology In Georgia, Mallory J. Harris, Ella Tessier-Lavigne, Erin Mordecai

Journal of the Georgia Public Health Association

Publishing Note: This article has been published in its peer-reviewed and accepted form as a post-print version. The fully formatted version of the article will be published on this record when it is available.

ABSTRACT

Background: As COVID-19 began to spread worldwide, local socioeconomic and health factors and nonpharmaceutical interventions may have affected epidemiological outcomes. To investigate the associations between public health orders, behavior, and population factors, and early epidemic dynamics, we investigated variation among counties in the U.S. state of Georgia. There, a large early outbreak occurred in March 2020 with varying levels of local nonpharmaceutical interventions prior to …

Zika Virus Concern And Preventative Behaviors During Pregnancy: Analysis Of 2017 Georgia Pregnancy Risk Assessment Monitoring System Data, Priya R. Nair, Christine E. Stauber

Journal of the Georgia Public Health Association

Background: Zika virus infection can cause severe health complications in pregnant women such as microcephaly and other congenital anomalies in the developing fetus but it can be prevented. It is imperative to develop an understanding of concern about Zika virus among pregnant women as this can influence their Zika virus preventative behaviors.

The purpose of this study was to gain an understanding of Zika virus concern among women in Georgia with live births in 2017 and to examine the frequency of condom use among those who were sexually active during their most recent pregnancy.

Methods: This cross- sectional study used …

The Clinicopathological Study And Associated Causes Of Pleural Effusions In Cats, Hsu Mon Hla

Chulalongkorn University Theses and Dissertations (Chula ETD)

Pleural effusion is an excessive and abnormal accumulation of fluid in the pleural space resulting from increased hydrostatic pressure, increased permeability of vascular capillary, and often leading to significant mortality. The objectives of this study were to investigate the clinicopathological parameters obtained by cytological and biochemical examination of pleural effusion and evaluate the correlations between the abnormality of these parameters and underlying causes of the pleural effusion in cats. This study was carried out in 127 cats with pleural effusion visiting the Small Animal Hospital, Faculty of Veterinary Science, Chulalongkorn University during the year 2020–2021. Pleural fluid samples were routinely …

Covid-19 Face Cover Tracker Using Amazon Web Services, Rahmanul Hoque

Computer Science

Numerous studies have shown that wearing face covers and following other social distancing guidelines reduce community transmission of air borne diseases like COVID-19 during a pandemic. While public health administrators can provide guidelines on wearing masks and social distancing, it cannot be guaranteed that everyone will follow those guidelines. It is very important to have a mechanism available for the public health administration to collect data on how well the population is following the guidelines provided. This information will allow them to anticipate when there will be peak hospitalization and prepare accordingly. This paper aims to look at the feasibility …

Correctional Case Planning: An Examination Into The Impacts Of Case Plans On Offender Recidivism, Jenna Lynn Borseth

Criminal Justice and Political Science

Case planning has become common practice within many correctional intervention programs. While the practice of case planning is not a new idea, it remains a largely neglected field within the study of offender rehabilitation. The current study seeks to expand this literature by investigating the effects of four case plan components: compliance, specificity (consisting of positively stated, measurable, and singular objectives), breadth, and expiration. To do so, the study examines 859 correctional case plans of offenders receiving treatment at a Halfway House facility. The results indicate that case plan compliance, breadth, and expiration are not significantly associated with offender recidivism. …

A New Molecular Approach To The Diagnosis Of Small Ruminant Morbillivirus Withevagreen Based Assay, Mustafa Emi̇n Öz, Emrah Torlak, Oğuzhan Avci, Müge Doğan, Ali̇ Tevfi̇k Uncu

Turkish Journal of Veterinary & Animal Sciences

The present work describes a new method that is anticipated to contribute to the global control and eradication strategies of small ruminant morbillivirus (SRMV), which negatively affects sheep and goat breeding in many countries where outbreaks emerge. Described assay was developed to detect SRMV by targeting the fusion glycoprotein gene. In the study, the EvaGreen based real-time RT-PCR method is compared with real-time RT-PCR based on TaqMan probe, which is recommended as the diagnostic test by World Organisation for Animal Health (OIE). Detection limit, normalized fluorescence values, and sensitivity of the methods were evaluated in the analysis. The lowest limit …

Isolation And Identification Of Clostridium Difficile From Cases Of Diarrhea In Young Farmanimals, And The Determination Of Antimicrobial Susceptibility, Edi̇z Kağan Özgen, Murat Yildirim

Turkish Journal of Veterinary & Animal Sciences

Clostridium difficile was isolated for the first time in 1935 from fecal samples of infants, although it was not until 1978 that its pathogenicity started to be considered, when it was shown to cause antibiotic-associated diarrhea and pseudomembranous colitis. In this study, it was aimed to determine the virulence and antibiotic resistance profiles of C. dificile in young ruminants with diarrhea and chickens fed on the farm. A total of 200 fecal samples (50 from calves, 50 from lambs and 50 from kid goats with neonatal diarrhea, as well as 50 cloacal swab samples taken from chickens) were taken and …

Detection Of Rhodococcus Equi By Pcr From Foals And Determination Of Antimicrobial Susceptibility, Şükrü Kirkan, Uğur Parin, Hafi̇ze Tuğba Yüksel Dolgun, Eli̇f Oya Oral

Turkish Journal of Veterinary & Animal Sciences

The scope of this research was determination of Rhodococcus equi isolates and antimicrobial susceptibilities in nasal swab specimen taken from animals between 0 and 6 months of age period. R. equi was identified from 10 isolates (11.1%) by automatic identification device. The verification of isolates were conducted by 16S ribosomal RNA PCR. VapA gene presence was detected in two (20%) isolates and multidrug resistance was identified against 11 antimicrobials. The antimicrobial resistance to macrolides and rifampin is arising worldwide since the excessive usage of the chemotherapeutics in various breeding farms just by evaluating monitoring outcomes. These results exhibit the presence …

Failure Of Passive Transfer In Neonatal Calves In Dairy Farms In Ankara Region, Erdal Kara, Ebubeki̇r Ceylan

Turkish Journal of Veterinary & Animal Sciences

This study, as a model for the farms in Turkey implementing professional herd management protocols, was conducted to examine a variety of factors in relation to the prevalence of failure of passive transfer (FPT) and the passive transfer (PT) in dairy farms in Ankara. A total of 400 calves and 363 cows from 9 different farms practicing professional herd management systems and employ full-time veterinarians were included in the study. Following the birth of the calf, colostrum was taken from cows, blood samples were taken from calves at 24-48 h of age and analysed for IgG using ELISA. FPT was …

Evaluation Of Survival Rate Of Fogera Calves And Their Crossbred At Chagni Cattle Breed Improvement And Andasa Livestock Research Centres, Tazeb Gessess, Godadaw Misganaw, Yohannes Dagnew

Turkish Journal of Veterinary & Animal Sciences

The study was conducted in Chagni Cattle Bred Improvement and Andassa Livestock Research Center of Western, Amhara region to evaluate the survival rate of pure Fogera and their HolsteinFriesian crossbred calves. A retrospective type of study design was used for conducting the study. The data used in the study was taken from the records of Chagni ranch and Andassa Livestock Research Center between 2011 and 2017. The survival rates were estimated by using cox regression and Kaplan-Meier model of Stata software. The mortality rate was 3% which was nearly the optimum level that many scholars agreed for successful rearing practices. …

Seroprevalence Of Bovine Viral Diarrhoea Virus, Bovine Herpesvirus Type 1 And Bovineherpesvirus Type 4 Infections In Cattle In Ağrı Province, Eastern Anatolia Region, Turkey, Mustafa Si̇nan Aktaş, Hasan Çeli̇k

Turkish Journal of Veterinary & Animal Sciences

This research was carried out to determine the seroprevalence of Bovine Viral Diarrhoea Virus (BVDV), Bovine Herpes Virus 1 (BoHV-1), and Bovine Herpes Virus 4 (BoHV-4) in cattle (n = 188) in Ağrı province of Eastern Anatolia Region, Turkey. The presence of BVDV, BoHV-1, and BoHV-4 antibodies in sera samples were determined by an ELISA test kit. It was determined that the highest seropositivity for BoHV-1 in Tutak disrict (9.9%), in ≤ 3 years age groups (3.39%), and in Simmental cattle (14.28%); for BoHV-4 in Doğubeyazıt disrict (4.16%), %), in ≤ 3 years age groups (1.70%), and in Simmental cross …

Adolescent Medical Decisionmaking Rights: Reconciling Medicine And Law, Doriane Lambelet Coleman, Philip M. Rosoff

Faculty Scholarship

Dennis Lindberg came into his aunt’s care when he was in the 4th grade because his parents struggled with drug addiction and could not provide for him. At thirteen, he was baptized in his aunt’s faith as a Jehovah’s Witness. Just days after he turned fourteen, on November 6, he was diagnosed with acute lymphoblastic leukemia.

The prognosis was that Dennis had a 75% chance of cure with standard oncology treatment. Consistent with the requirements of his new faith, however, Dennis told his doctors, “I do not want to be treated if the requirement is that I would have to …

Macromedical Regulation, Barak D. Richman, Steven L. Schwarcz

Faculty Scholarship

The COVID-19 pandemic has dramatically shown that a localized disease can be transmitted to the broader population, nationally and worldwide. This Article analyzes how to design regulation to help control that transmission. To that end, we first observe that existing healthcare regulation focuses almost exclusively on regulating individual components of the medical and healthcare industry, while lacking a capacity to address how those components work together as a system -a system that pandemics can destabilize. Indeed, one factor that contributed to COVID-19's spread was the inability of U.S. healthcare regulation to operate on a societal level, to protect certain components …

The Clean Air Act Of 1963: Postwar Environmental Politics And The Debate Over Federal Power, Adam D. Orford

Faculty Scholarship

This Article explores the development of the Clean Air Act of 1963, the first law to allow the federal government to fight air pollution rather than study it. The Article focuses on the postwar years (1945-1963) and explores the rise of public health medical research, cooperative federalism, and the desire to harness the powers of the federal government for domestic social improvement, as key precursors to environmental law. It examines the origins of the idea that the federal government should “do something” about air pollution, and how that idea was translated, through drafting, lobbying, politicking, hearings, debate, influence, and votes, …

2020 Domestic Legislative Review, Tara Cooley

Animal Law Review

The 116th Congress, second session, began January 3, 2020, and ended January 3, 2021. While Congress voted on key animal-related legislation, such as the Big Cat Public Safety Act, the COVID-19 pandemic slowed -- or even halted -- proposed legislation at the federal and state levels. Despite the slowdown, local voters proposed and enacted several key initiatives, including the California Ecosystems Protection Act and Orange County, Florida's Right to Clean Water initiative.9 In addition, federally enacted COVID-19-related legislation, such as the Coronavirus Aid, Relief, and Economic Security (CARES) Act, also addressed animalrelated issues. The World Health Organization (WHO) labeled COVID-19 …