Digital Commons Network^™

Re-Emphasizing African Bioethics In Light Of Potential Crispr-Based Treatment For Hiv And Sickle Cell Disease, Taylor Daniel

Vanderbilt Journal of Transnational Law

Recent genetic studies indicate that CRISPR-Cas9, a biological gene-editing mechanism derived from bacteria, may be capable of curing HIV and Sickle Cell Disease. Clinical research for HIV and SCD is prevalent in African nations because of the high incidence of those diseases in all forms. Because past research studies in Africa demonstrate how Western companies can abuse lax ethics regulations in developing African nations, ethics systems must prevent this new, potentially far-reaching CRISPR technology from being prematurely and unethically used on African research participants. In updating current international bioethics frameworks, drafters should pay particular attention to its application in African …

Public Health In The Opioid Litigation, Daniel G. Aaron

Utah Law Faculty Scholarship

Today, the opioid crisis is playing out in the nation’s courts. Litigants have taken a microscope to defendant opioid companies whose misconduct ignited and exacerbated the opioid crisis. As the litigation continues, one could imagine numerous ways its resolution could contribute to the end of a multi-decade overdose crisis and prevent future ones. Options include holding defendant companies accountable, releasing previously secret information for research on root causes of the epidemic, and prohibiting future misconduct through injunctive relief. Unfortunately, to date, the litigation has not been so capacious. Rather, the participants—judge included—have been preoccupied with rapid monetary settlement. Though understandable, …

Transcriptional Regulation Of Duox-Dependent Reactive Oxygen Species Production Against Bacterial Infection In The Gut Of Cat Fleas (Ctenocephalides Felis)., Ryne W. Maness

College of Graduate Studies: Theses & Dissertations

Fleas (Order Siphonaptera) are opportunistic blood feeders that parasitize a wide variety of mammals and birds. They also transmit bacterial pathogens that cause diseases in humans (e.g., murine typhus, flea-borne spotted fever, cat scratch disease, and plague). Because they acquire infectious pathogens while blood feeding, the flea gut is considered to be the initial site of infection. While immune responses have been well documented in other disease vectors, few studies have identified the immune mechanisms involved in defense of the flea gut. In other hematophagous insects, the synthesis of reactive oxygen species (ROS) is the immediate immune defense mechanism against …

Risk Factors And Trends In Antimicrobial Susceptibility Patterns In Strains Of Neisseria Gonorrhoeae Following Changes In The Cdc Sexually Transmitted Disease (Std) Treatment Guidelines – United States, 2012-2018, Niketta A. Womack

College of Graduate Studies: Theses & Dissertations

Antimicrobial resistant Neisseria gonorrhoeae (N. gonorrhoeae) has become a major global public health concern in the 21st century. Surveillance activities are essential in identifying risk factors in priority populations. The purpose of this study was to identify risk factors associated with and trends in antimicrobial susceptibility patterns in N. gonorrhoeae strains identified through the Gonococcal Isolate Surveillance Project (GISP). A study sample of 37,157 men was evaluated to measure adherence to changes in CDC’s STD treatment guidelines in 2012 and 2015. Data were analyzed to measure associations between independent and dependent variables by conducting bivariate and logistic regression …

Influence Of Political Affiliation On Perceived Media Bias And Trustworthiness In The Covid-19 Pandemic, Tabitha Lamberth

College of Graduate Studies: Theses & Dissertations

Partisanship and news source attribution may influence perceived media bias and trust in COVID-19 information. This study aimed to explore how the similarity liking effect relates to political identity and perceived credibility. Our main hypothesis was that individuals would find news sources that shared their political affiliation as more trustworthy than other news sources. To test our hypothesis, 216 undergraduate students participated in a study that measured participants’ trustworthiness of a news article with randomized source attribution from a liberal, conservative, and neutral source. A 2X3 ANOVA tested the relationship between our participants’ political affiliation, measured by the 12-item Social …

Prevalence Of Asymptomatic P. Falciparum Gametocyte Carriage Among School Children In Mbita, Western Kenya And Assessment Of The Association Between Gametocyte Density, Multiplicity Of Infection And Mosquito Infection Prevalence., Victor A. Mobegi, Jeremy K. Herren, Abdoulie O. Touray, Fred Wamunyokoli, Hellen Butungi

All Peer-Reviewed Publications

Background: Asymptomatic Plasmodium falciparum gametocyte carriers are reservoirs for sustaining transmission in malaria endemic regions. Gametocyte presence in the host peripheral blood is a predictor of capacity to transmit malaria. However, it does not always directly translate to mosquito infectivity. Factors that affect mosquito infectivity include, gametocyte sex-ratio and density, multiplicity of infection (MOI), and host and vector anti-parasite immunity. We assess the prevalence of gametocyte carriage and some of its associated risk factors among asymptomatic schoolchildren in Western Kenya and to further analyse the association between gametocyte density, multiplicity of infection (MOI) and mosquito infection prevalence. Methods: P. falciparum …

Immunoglobulins And Acute Phase Proteins In Van Cats - Associations With Sex, Age, Andeye Colour, Pinar Coşkun, Vahdetti̇n Altunok, Fi̇li̇z Kazak, Nazmi̇ Yüksek

Turkish Journal of Veterinary & Animal Sciences

It was aimed to determine concentrations of plasma immunoglobulins (IgG, IgA, IgM) and acute phase proteins (?-1 acid glycoprotein, serum amyloid A, ceruloplasmin) and the association of these parameters with age, sex, and eye colour in Van cats. Blood plasma of healthy, forty-seven Van cats (Van Cat Home) fed with standard cat food were involved in the study. Cats were divided into four groups based on age ( 5) and eye colour (amber-amber, amber-blue, blue-amber, and blue-blue eyes described from left to right), and two groups based on sex (male and female). Plasma IgG, IgA, IgM, ?-1 acid glycoprotein, serum …

Life In A Time Of Covid: A Mixed Method Study Of The Changes In Lifestyle, Mental And Psychosocial Health During And After Lockdown In Western Australians, Ranila Bhoyroo, Paola Chivers, Lynne Millar, Caroline Bulsara, Ben Piggott, Michelle Lambert, Jim Codde

Research outputs 2014 to 2021

Background: Since the beginning of the COVID-19 pandemic, the Western Australian government imposed multiple restrictions that impacted daily life activities and the social life. The aim of this study was to examine the effects of COVID-19 lockdown on the community’s physical, mental and psychosocial health. Methods: Approximately 2 months after a three-month lockdown, a cross-sectional study was opened to Western Australian adults for an 8-week period (25th August – 21 October 2020). Participants competed a 25-min questionnaire adapted from the Western Australia Health and Wellbeing Surveillance system. Participants provided information on their socio-demographic status, lifestyle behaviours, mental health, and psychosocial …

Risk Factors For Covid-19 Infection, Disease Severity And Related Deaths In Africa: A Systematic Review, Hailay Abrha Gesesew, Digsu Negese Koye, Dagnachew Muluye Fetene, Mulu Woldegiorgis, Yohannes Kinfu, Ayele Bali Geleto, Yohannes Adama Melaku, Hassen Mohammed, Kefyalew Addis Alene, Mamaru Ayenew Awoke, Mulugeta Molla Birhanu, Amanuel Tesfay Gebremedhin, Yalemzewod Assefa Gelaw, Desalegn Markos Shifti, Muluken Dessalegn Muluneh, Teketo Kassaw Tegegne, Solomon Abrha, Atsede Fantahun Aregay, Mohammed Biset Ayalew, Abadi Kahsu Gebre, Kidane Tadesse Gebremariam, Tesfaye Gebremedhin, Lemlem Gebremichael, Cheru Tesema Leshargie, Getiye Dejenu Kibret, Maereg Wagnew Meazaw, Alemayehu Berhane Mekonnen, Dejen Y. Tekle, Azeb G. Tesema, Fisaha H. Tesfay, Wubshet Tesfaye, Befikadu L. Wubishet, Berihun A. Dachew, Akilew A. Adane

Research outputs 2014 to 2021

© BMJ Publishing Group Limited 2020. Objective The aim of this study was to provide a comprehensive evidence on risk factors for transmission, disease severity and COVID-19 related deaths in Africa. Design A systematic review has been conducted to synthesise existing evidence on risk factors affecting COVID-19 outcomes across Africa. Data sources Data were systematically searched from MEDLINE, Scopus, MedRxiv and BioRxiv. Eligibility criteria Studies for review were included if they were published in English and reported at least one risk factor and/or one health outcome. We included all relevant literature published up until 11 August 2020. Data extraction and …

A Randomized, Controlled Study On The Safety And Efficacy Of Maraviroc And/Or Favipiravir Vs Currently Used Therapy In Severe Covid-19 Adults. “Comvivir” Trial., Adolfo Pérez-García, Alma Villalobos-Osnaya, Maria Luisa Hernández-Medel, Lucia Monserrat Perez-Navarro, Elba O. Medina-Hernandez, Diana Soa Cabrera-Orejuela, Ana Maria Espinoza-Garcia, Mireya Leon-Hernandez, Juan Carlos Lopez Alvarenga, Srinivas Mummidi

School of Medicine Publications

Multiple studies have established that hyperinflammatory response induced by SARS CoV-2 is a main cause of complications and death in infected subjects. Such dysfunctional immune response has been described as a dysregulated and exacerbated production of cytokines and chemokines that attracts and activates inflammatory cells, which start and sustain pulmonary and systemic damage, thus causing complications that lead to multi organ failure and death. Therefore, we suggest that blocking key inflammation receptors could help to reduce migration and activation of T cells, monocytes/macrophages and neutrophils, thus mitigating the cytokine dysregulation and averting severe complications and death. Importantly, the optimum treatment …

Antibiotic Development Incentives That Reflect Societal Value Of Antibiotics, Helen Boucher, Thomas M. File, Vance Fowler, Amanda Jezek, John Rex, Kevin Outterson

Faculty Scholarship

TO THE EDITOR—Rome and Kesselheim [1] claimed that rewarding developers of novel antibiotics with transferable exclusivity vouchers is an expensive approach to promoting antibiotic development. This analysis is incomplete as it focuses only on the cost of bringing new antibiotics to market without acknowledging their societal value. The authors also did not suggest an alternative approach. With patients running out of treatment options for resistant infections, failing to strengthen the antibiotic pipeline is not a reasonable option.

Divergent Attitudes Regarding The Benefits Of Face Masks In Aviation Colleges And Universities, Andrew R. Dattel, Peiheng Gao, Hanzi Xie, Maxine E. Lubner

Publications

Opinions and practices regarding face masks (FM) to attenuate COVID-19’s spread remains polarized across the United States. We examined whether these attitudes extend to the aviation collegiate community. A 14-question survey was sent to 90 aviation colleges and universities throughout the country. Responses were solicited from students, faculty, and staff. Of the 598 respondents, 77% were students, 13% were faculty, and 10% were staff. Pilots comprised 66% of the respondents. A Principal Component Analysis reduced the questions to two scales: Benefits and Inconvenience. Females, non-pilots, and older respondents reported greater benefits to wearing a FMand fewer inconveniences. A multiple regression …

Knowledge, Attitude And Perception Of People Towards The Novel Coronavirus Disease (Covid-19) Outbreak And Its Effects On Their Livelihoods: Perspectives From Diverse Populations, James Adefisoye

All Publications

Background: People’s behavior and compliance with COVID-19 control measures is associated with their knowledge, attitude and perceptions (KAP). To this end, we investigated the KAP among people from diverse populations towards the COVID-19 pandemic. We also examined the impact of the outbreak on their livelihoods.

Methods: A cross sectional study with the adoption of a 31-item questionnaire divided into five sections namely demographics, knowledge, attitudes, perception and effect on livelihood. Six countries were considered with Australia, United Kingdom and USA in developed countries category; India, Nigeria and South Africa were considered in developing countries category. Reponses were compared by development …

J Mich Dent Assoc January 2021

The Journal of the Michigan Dental Association

Every month, The Journal of the Michigan Dental Association brings news, information, and features about Michigan dentistry to our state's oral health community and the MDA's 6,200+ members. No publication reaches more Michigan dentists!

In this issue, the reader will find the following original content:

• A cover story on “The Dentist’s Role in Recognizing Sleep-Disordered Breathing in Children”.
• A feature article, “Dental Sleep Medicine Education: Do You Want a Nap or a Full Night’s Sleep?”.
• The feature article, “In-office Plans: Where Are We Now? What Have We Learned?”
• News you need, Editorial and regular department articles on MDA Foundation activities, …

Liver Injury As A Surrogate For Inflammation And Predictor Of Outcomes In Covid-19, Kajali Mishra, Sandra Naffouj, Sarah Gorgis, Hanan Ibrahim, Sonika Gill, Raef Fadel, Abigail Chatfield, Amy Tang, Reena Salgia

Internal Medicine Articles

Respiratory failure is the most common cause of death in patients with corona virus disease 2019 (COVID-19). There have been many investigations to determine predictors of bad outcomes in patients with this illness. Liver enzyme elevation has been described in hospitalized patients with severe COVID-19; however, little is known about the significance of liver injury regarding outcomes. We conducted a retrospective chart review of 348 patients admitted with COVID-19 in our quaternary care center. Liver injury on admission was defined based on the laboratory cutoff of aspartate aminotransferase >35 IU/L and/or alanine aminotransferase >52 IU/L. Patients were divided into two …

Bayesian-Derived Vancomycin Auc24h Threshold For Nephrotoxicity In Special Populations, Dan Ho

University of the Pacific Theses and Dissertations

A Bayesian-derived 24-hour area under the concentration-time curve over minimum inhibitory concentration from broth microdilution (AUC24h/MICBMD) ratio of 400 to 600 is recommended as the new monitoring parameter for vancomycin to optimize efficacy and minimize nephrotoxicity. The AUC24h threshold of 600 mg*h/L for nephrotoxicity was extrapolated from studies that assessed the general population. It is unclear if this upper threshold is consistent or varies when used in special populations such as critically ill patients, obese patients, patients with preexisting renal disease, and patients on concomitant nephrotoxins.The purpose of this study is to investigate the generalizability of the proposed vancomycin AUC24h …

First Report On Mild Insecticide Resistance In Newly Established Aegean Aedes Albopictus Populations Of Turkey, Sare İlknur Yavaşoğlu

Turkish Journal of Zoology

The invasive nature of Aedes albopictus, a competent vector of dengue, zika, yellow fever, and chikungunya viruses, has spread to many parts of the world. To date, there have been no report regarding the insecticide resistance status of Aedes albopictus populations along the Aegean coasts of Turkey. This study aims to confirm the occurrence of Aedes albopictus populations in the Aegean region of Turkey and test their susceptibility against different insecticide classes. Bioassay for susceptibility to Dikloro difenil trikloroetan (DDT) (4%), propoxur (0.1%), fenitrothion (1%), bendiocarb (0.1%), permethrin (0.75%), and deltamethrin (0.05%) of each population was assessed through the World …

Understanding The Public Sentiment And Discourse On Covid-19 Vaccine, Kruttika Sutrave, Rajesh Godasu, Jun Liu

Research & Publications

The novel Coronavirus disease has negatively impacted human lives in various aspects leading to the global health crisis and economic fallout. The availability of vaccines in the U.S. is a relief. However, many people are not in favor of the COVID-19 vaccine. The study aimed to identify the emotions and themes of discourse related to the COVID-19 vaccine posted on Twitter. Sentiment analysis and topic modeling techniques were employed to discover the sentiment and prevalent themes. The findings suggest that overall, the public has positive opinions towards the vaccine. Those people that show positive opinions appreciate the efforts of leadership, …

Current Status Of The Biology, Pathogenesis, And Impacts Of Ebola Virus, Dalal Alamri

Microbiological Sciences

Ebola viruses (EV) are single-stranded negative-sense RNA viruses belonging to the Filoviridae family. There are 6 species of Ebola, and four of them can cause Ebola virus disease (EVD) in humans. Ebola viral hemorrhagic fever is one of the deadliest diseases known to infect humans and non-human primates. The primary mode of transmission of Ebola has been identified as direct contact with infected animals, humans and body fluids. The early diagnosis of EVD is difficult because of similarities of the initial disease presentation to influenza-like symptoms such as high fever, myalgia, fatigue, headache, and chills. The most common symptoms that …

Descriptive Norms And Prototypes Predict Covid-19 Prevention Cognitions And Behaviors In The United States: Applying The Prototype Willingness Model To Pandemic Mitigation, Laurel M. Peterson, Marie Helweg-Larsen, Sarah Dimuccio

Psychology Faculty Research and Scholarship

Background

Early in the COVID-19 pandemic, prevention behavior adoption occurred in a rapidly changing context. In contrast to expectancy-value theories, the Prototype Willingness Model (PWM) is well-suited for investigating novel and socially informed behaviors. Purpose

We explored whether PWM social cognitions predicted coronavirus prevention behaviors. Method

A representative sample of United States adults (N = 738; M_age = 46.8; 51.8% women; 78% white; April 2020) who had not had COVID-19 reported PWM predictor variables (perceived vulnerability, prevention descriptive norms, prototypes engaging in prevention behavior, and prevention behavioral intentions). Two weeks later, participants reported their prevention behaviors (handwashing, mask-wearing, social …

Collaborative Governance Under The Endangered Species Act: An Empirical Analysis Of Protective Regulations, Robert L. Fischman, Vicky J. Meretsky, Matthew P. Castelli

Articles by Maurer Faculty

Recent conservation and administrative law scholarship emphasizes the need for potential legal adversaries to work together. Stakeholders and regulators can pool their political capital, money, property, expertise, and legal leverage to achieve more than could be accomplished through mere mechanical implementation of statutory commands. Most commentators associate collaboration with programs promoting fuzzy objectives to engage the public and advisory groups.

The Endangered Species Act (ESA) is a polarizing statute that imposes seemingly uncompromising mandates. But this Article demonstrates that the ESA actually provides rich opportunities for collaborative governance. In exploring this underappreciated success story, we document how conservation collaboration adapts …

Audit Of Waste Collected Over One Week From Superior Dental Health Of Lincoln, Bryclin Alstrom

Department of Environmental Studies: Undergraduate Student Theses

A waste audit of Superior Dental Health of Lincoln was conducted in order to propagate the implementation of sustainable waste management practices within the company. Differentiating between hazardous waste and solid waste is necessary for environmentally friendly waste management and ceasing the spread of infectious pathogens. The audit identified nine different materials contributing to the biomedical waste stream of the company. Of which, personal protective equipment (PPE) is of major concern due to the financial commitment necessary to acquire / dispose of these products, as well as the strain in supply due to the current COVID-19 pandemic. The results of …

Of Pigs And Men: The Best-Laid Plans For Prevention And Control Of Swine Fevers, Jishu Shi, Lihua Wang, David Scott Mcvey

School of Veterinary and Biomedical Sciences: Faculty Publications

John Steinbeck drew the title of his novel “Of Mice and Men” from a line in a Robert Burns poem “To a mouse”: “The best-laid plans of mice and men/Go often awry.” Unlike John Steinbeck who used the title to mirror the characters who were struggling during the Great Depression to the mouse whose nest was accidentally destroyed by the poet (Burns 1785), we chose this line to emphasize that the best-laid plan can go wrong in infectious disease control and prevention. Here, we will discuss the contributing factors behind the global successes and failures in the prevention and control …

Impact Of The Histidine‐Containing Phosphocarrier Protein Hpr On Carbon Metabolism And Virulence In Staphylococcus Aureus, Linda Pätzold, Anne-Christine Brausch, Evelyn-Laura Bielefeld, Lisa Zimmer, Greg A. Somerville, Markus Bischoff, Rosmarie Gaupp

School of Veterinary and Biomedical Sciences: Faculty Publications

Carbon catabolite repression (CCR) is a common mechanism pathogenic bacteria use to link central metabolism with virulence factor synthesis. In gram‐positive bacteria, catabolite control protein A (CcpA) and the histidine‐containing phosphocarrier protein HPr (encoded by ptsH) are the predominant mediators of CCR. In addition to modulating CcpA activity, HPr is essential for glucose import via the phosphotransferase system. While the regulatory functions of CcpA in Staphylococcus aureus are largely known, little is known about the function of HPr in CCR and infectivity. To address this knowledge gap, ptsH mutants were created in S. aureus that either lack the open reading …

An Evaluation Of The Anti-Carcinogenic Response Of Major Isothiocyanates In Non-Metastatic And Metastatic Melanoma Cells, Melina Mitsiogianni, Sotiris Kyriakou, Ioannis Anestopoulos, Dimitrios T. Trafalis, Maria V. Deligiorgi, Rodrigo Franco, Aglaia Pappa, Mihalis I. Panayiotidi

School of Veterinary and Biomedical Sciences: Faculty Publications

Malignant melanoma is one of the most deadly types of solid cancers, a property mainly attributed to its highly aggressive metastatic form. On the other hand, different classes of isothiocy- anates, a class of phytochemicals, present in cruciferous vegetables have been characterized by considerable anti-cancer activity in both in vitro and in vivo experimental models. In the current study, we investigated the anti-cancer response of five isothiocyanates in an in vitro model of melanoma consisting of non-metastatic (A375, B16F-10) and metastatic (VMM1, Hs294T) malignant melanoma as well as non-melanoma epidermoid carcinoma (A431) and non-tumorigenic melanocyte-neighboring keratinocyte (HaCaT) cells. Our aim …

Inhibition Of Zika Virus Replication By G-Quadruplex-Binding Ligands, Prativa Majee, Aryamav Pattnaik, Bikash R. Sahoo, Uma Shankar, Asit K. Pattnaik, Amit Kumar, Debasis Nayak

School of Veterinary and Biomedical Sciences: Faculty Publications

Zika virus (ZIKV), a mosquito-transmitted Flavivirus, emerged in the last decade causing serious diseases and affecting human health globally. Currently, no licensed vaccines or antivirals are available to combat ZIKV, although several vaccine candidates are in the pipeline. In recent years, the presence of non-canon- ical G-quadruplex (GQ) secondary structures in viral genomes has ignited significant attention as potential targets for anti- viral strategy. In this study, we identified several novel conserved potential GQ structures by analyzing published ZIKV genome sequences using an in-house algorithm. Bio- physical and biochemical analysis of the RNA sequences con- taining these potential GQ sequences …

Il-10 As A Th2 Cytokine: Differences Between Mice And Humans, Mahima T. Rasquinha, Meghna Sur, Ninaad Lasrado, Jay Reddy

School of Veterinary and Biomedical Sciences: Faculty Publications

The discovery of interleukin (IL)-10 more than 30 years ago marked the beginning of our understanding of how cytokines regulate immune responses, based on cross-regulation between T helper (Th)1 and Th2 cytokines. Although multiple cell types were shown to produce IL-10, its identity as a Th2 cytokine remained strong since it was rigidly associated with Th2 clones in mice, whereas both Th1 and Th2 clones could secrete IL-10 in humans. However, as new Th1/Th2 cell functionalities emerged, anti-inflammatory action of IL-10 gained more attention than its inhibitory effect on Th1 cells, which may occur as an indirect consequence of suppression …

High Prevalence Of Pre-Existing Serological Cross-Reactivity Against Severe Acute Respiratory Syndrome Coronavirus-2 (Sars- Cov-2) In Sub-Saharan Africa, For Yue Tso, Salum Lidenge, Phoebe B. Peña, Ashley A. Clegg, John R. Ngowi, Julius Mwaiselage, Owen Ngalamika, Peter Julius, John T. West, Charles Wood

Nebraska Center for Virology: Faculty Publications

Objective: Significant morbidity and mortality have occurred in the USA, Europe, and Asia due to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), whereas the numbers of infections and deaths in sub-Saharan Africa (SSA) have remained comparatively low. It has been hypothesized that exposure of the population in SSA to other coronaviruses prior to the COVID-19 pandemic resulted in some degree of cross-protection against SARS-CoV-2 infection and pathogenesis. We evaluated this hypothesis by comparing SARS-CoV-2 cross-reactive antibodies in pre-pandemic plasma samples collected from SSA and the USA.

Method: Pre-COVID-19 pandemic plasma samples from SSA and the USA were collected and tested by …

Chlorovirus Pbcv-1 Multidomain Protein A111/114r Has Three Glycosyltransferase Functions Involved In The Synthesis Of Atypical N-Glycans, Eric Noel, Anna Notaro, Immacolata Speciale, Garry A. Duncan, Cristina De Castro, James L. Van Etten

Nebraska Center for Virology: Faculty Publications

The structures of the four N-linked glycans from the prototype chlorovirus PBCV-1 major capsid protein do not resemble any other glycans in the three domains of life. All known chloroviruses and antigenic variants (or mutants) share a unique conserved central glycan core consisting of five sugars, except for antigenic mutant virus P1L6, which has four of the five sugars. A combination of ge- netic and structural analyses indicates that the protein coded by PBCV-1 gene a111/114r, conserved in all chloroviruses, is a glycosyltransferase with three putative domains of approximately 300 amino acids each. Here, in addition to in silico sequence …

Strategies Targeting Hemagglutinin As A Universal Influenza Vaccine, Brianna L. Bullard, Eric A. Weaver

Nebraska Center for Virology: Faculty Publications

Influenza virus has significant viral diversity, both through antigenic drift and shift, which makes development of a vaccine challenging. Current influenza vaccines are updated yearly to in- clude strains predicted to circulate in the upcoming influenza season, however this can lead to a mismatch which reduces vaccine efficacy. Several strategies targeting the most abundant and im- munogenic surface protein of influenza, the hemagglutinin (HA) protein, have been explored. These strategies include stalk-directed, consensus-based, and computationally derived HA immunogens. In this review, we explore vaccine strategies which utilize novel antigen design of the HA protein to improve cross-reactive immunity for development …