Digital Commons Network^™

Kat8 Beyond Acetylation: A Survey Of Its Epigenetic Regulation, Genetic Variability, And Implications For Human Health, Lindsey Yoo, David Mendoza, Allison J. Richard, Jacqueline M. Stephens

Division of Basic Science Faculty Publications

Lysine acetyltransferase 8, also known as KAT8, is an enzyme involved in epigenetic regulation, primarily recognized for its ability to modulate histone acetylation. This review presents an overview of KAT8, emphasizing its biological functions, which impact many cellular processes and range from chromatin remodeling to genetic and epigenetic regulation. In many model systems, KAT8’s acetylation of histone H4 lysine 16 (H4K16) is critical for chromatin structure modification, which influences gene expression, cell proliferation, differentiation, and apoptosis. Furthermore, this review summarizes the observed genetic variability within the KAT8 gene, underscoring the implications of various single nucleotide polymorphisms (SNPs) that affect its …

Exploring The Effects Of N,N-Dimethylbiguanide And Ω-3 Pufas On Muscle Stem Cell Differentiation, Enayah Alhshim

Graduate Theses and Dissertations

The impacts of omega-3 (ω-3) fatty acid and metformin hydrochloride (Met-HCl) on muscle stem cells differentiation, mimicking the fetal muscle development under gestational diabetes mellitus (GDM), were investigated. ω-3 fatty acids have been known for their ability to regulate adipogenic transcription factors such as Sterol Regulatory Element-Binding Protien (SREBPs) and Peroxisome Proliferator-Activated Receptors (PPARs). This regulation resulted in gene expression modification for lipid metabolism and adipocyte differentiation, thus preventing excessive fat accumulation. Additionally, emerging evidence suggested that ω-3 fatty acids may also exert direct effects on myogenic processes that influence muscle stem cells proliferation, differentiation, and maturation. Meanwhile, Met-HCl, an …

Sarcopenia And The Importance Of Resistance Training And Protein-Rich Diets For Prevention Of Muscle Loss In Older Adults: A Literature Review And Informational Pamphlet, Madison Steele

Honors Program: Senior Projects (Public)

The growing prevalence of sarcopenia among older adults as well as youths has prompted further research aimed at developing effective preventative measures and treatment plans. Sarcopenia is often thought to occur solely due to aging, but several other factors contribute to progressive muscle loss. Previous research studies have found an effect of physical activity and dietary protein levels on the risk of developing sarcopenia as well as its onset age. This study aims to review existing knowledge in the field to compile an extensive list of sarcopenia causes and methods of prevention. The main causes identified in this review are …

Lack Of Access To Healthcare And Neurology Within East Texas, Ashton Arlen

Health, Human Performance and Recreation Undergraduate Honors Theses

Within East Texas, there is a critical shortage of physicians and lack of access to healthcare that is taking a major toll on the health of residents. For Texas as a whole, almost 70% of their 254 counties are classified as a rural. Within the United States, Texas has the largest amount of hospital closures and rural areas including East Texas have lost over half of their hospitals since 1960 (Nevins et al. 2021). The area endures some of the highest rates of chronic health conditions such as obesity, diabetes, cancer, and mental health conditions.

In knowing about the many …

Development And Usage Of Analytic Tools And Recommendations For Validation And Reliability Studies Using Consumer-Grade Wearable Technology, Bryson Carrier

UNLV Theses, Dissertations, Professional Papers, and Capstones

Introduction: Wearable technology is increasingly utilized across various fields, yet the validity and reliability of the physiological data these devices provide are often unverified due to a lack of rigorous testing standards.

Purpose: This dissertation contains three primary works, and therefore multiple purposes. The purpose of the first project (Chapter 2) is to introduce a new risk of bias assessment tool, specifically for assessing methodological quality and the risk of bias in validity and reliability studies using wearable technology, with a focus on consumer-grade wearable technology. The purpose of the second project (Chapter 3) was to perform a systematic review …

Effectiveness Of A Virtual Simulation Program As A Novel Approach To Improve Clinical Judgment In Prelicensure Nursing Students, Monica Millard

UNLV Theses, Dissertations, Professional Papers, and Capstones

Problem: Limited clinical placement opportunities for practicing decision-making skills have widened the academic-practice gap. Research shows a disturbing decline in entry-level competency among newly graduated registered nurses. Innovative strategies like virtual patient simulation may foster decision-making skills and prepare prelicensure nursing students for practice. However, research is lacking in examining virtual patient simulation (VPS) as an effective approach for developing clinical judgment in prelicensure nursing students. The American Association for Academic Nursing has determined that clinical judgment is an essential nursing attribute. Moreover, the National Council of State Boards of Nursing developed the Next Generation National Council Licensure Exam based …

Sound Marks, Deborah R. Gerhardt, Jon J. Lee

Minnesota Law Review Vols. 106:2 onward (2021-present)

A lion roars just before a film rolls. A doughboy giggles. A giant green man laughs a hearty, “Ho, Ho, Ho.” These iconic sounds are all federally registered as trademarks. They identify specific brands and distinguish their products and services from the competition. Human brains treat sounds like these as categorization tools and cognitive shortcuts--ideal trademark symbols. But what about the sounds your favorite toys or electronic devices make? Or those made by a fictional character in the latest blockbuster? This Article tackles these issues and others. We push back against the widely-held belief that all unconventional trademarks--product designs, colors, …

Modeling Acute Myocardial Infarction And Cardiac Fibrosis Using Human Induced Pluripotent Stem Cell-Derived Multi-Cellular Heart Organoids, Myeongjin Song, Da Bin Choi, Jeong Suk Im, Ye Na Song, Ji Hyun Kim, Hanbyeol Lee, Jieun An, Ami Kim, Hwan Choi, Joon-Chul Kim, Choongseong Han, Young Keul Jeon, Sung Joon Kim, Dong-Hun Woo

Faculty, Staff and Student Publications

Heart disease involves irreversible myocardial injury that leads to high morbidity and mortality rates. Numerous cell-based cardiac in vitro models have been proposed as complementary approaches to non-clinical animal research. However, most of these approaches struggle to accurately replicate adult human heart conditions, such as myocardial infarction and ventricular remodeling pathology. The intricate interplay between various cell types within the adult heart, including cardiomyocytes, fibroblasts, and endothelial cells, contributes to the complexity of most heart diseases. Consequently, the mechanisms behind heart disease induction cannot be attributed to a single-cell type. Thus, the use of multi-cellular models becomes essential for creating …

Development And Characterization Of A Low Intensity Vibrational System For Microgravity Studies, Omor Khan

Boise State University Theses and Dissertations

The advent of extended-duration human spaceflight demands a better comprehension of the physiological impacts of microgravity. One primary concern is the adverse impact on the musculoskeletal system, including muscle atrophy and bone density reduction. Ground-based microgravity simulations have provided insights, with vibrational bioreactors emerging as potential mitigators of these negative effects. Despite the potential they have, the adaptation of vibrational bioreactors for space remains unfulfilled, resulting in a significant gap in microgravity research. This paper introduces the first automated low-intensity vibrational (LIV) bioreactor designed specifically for the International Space Station (ISS) environment. Our research covers the bioreactor's design and characterization, …

Local Anesthetic Systemic Toxicity: Last Protocol Development, Implementation, And Evaluation For Healthcare Providers, Rachel Vaughn

Doctor of Nursing Practice Projects

LAST is an uncommon but deadly complication of local anesthetic administration. Healthcare facilities benefit from protocol implementation to help streamline best evidence-based practice. The American Society of Regional Anesthesia and Pain Medicine warrants a LAST emergency protocol for any healthcare facility practicing regional anesthesia. Healthcare personnel encountering patients at risk for LAST must understand the symptoms and treatment of LAST to improve response time and patient outcomes. The project implemented a LAST protocol at a rural hospital in Southern Illinois in July 2023. The investigator held an educational service to discuss the new LAST protocol and implementation. The educational service …

Implementation And Effectiveness Of Stress Management Strategies Among Stem Students At The University Of Nebraska-Lincoln, Dylan Hiser

Honors Program: Senior Projects (Public)

High-stakes exams often induce significant stress among STEM (Science, Technology, Engineering, and Math) students, impacting their academic performance and overall well-being. As the opportunity for careers in STEM grows rapidly, understanding the stressors that students face remains critical in mitigating the effects of this stress and ensuring the success of these students. The objective of this study is to determine how well STEM students respond to recommended interventions that mitigate exam stress and to identify trends in these students’ exam scores. To accomplish this, a set of surveys was sent to undergraduate STEM students at the University of Nebraska-Lincoln. The …

The Biochemical And Metabolic Impact Of 8-Weeks Of Intermittent Energy Restriction On Resistance-Trained Adults: A Pilot Study, Dillon Wells

Masters Theses, 2020-current

Objective: The objective of this study was to evaluate the effects of refeeds and diet breaks on biochemical, body composition, and resting metabolic rate (RMR) measures during an energy-restricted diet.

Methods: Resistance-trained men between the ages of 18-45 participated in an 8-week IER weight loss diet plan. Participants were randomly assigned to one of two dietary intervention groups: Group 1 received two days/week of refeeds (REF), and Group 2 received a one-week diet break every two weeks (BRK). All participants followed a standardized volume weight training protocol. Baseline and post-intervention dual-energy X-ray absorptiometry (DXA) scans and blood measures were conducted …

Igwas: Image-Based Genome-Wide Association Of Self-Supervised Deep Phenotyping Of Retina Fundus Images, Ziqian Xie, Tao Zhang, Sangbae Kim, Jiaxiong Lu, Wanheng Zhang, Cheng-Hui Lin, Man-Ru Wu, Alexander Davis, Roomasa Channa, Luca Giancardo, Han Chen, Sui Wang, Rui Chen, Degui Zhi

Faculty, Staff and Student Publications

Existing imaging genetics studies have been mostly limited in scope by using imaging-derived phenotypes defined by human experts. Here, leveraging new breakthroughs in self-supervised deep representation learning, we propose a new approach, image-based genome-wide association study (iGWAS), for identifying genetic factors associated with phenotypes discovered from medical images using contrastive learning. Using retinal fundus photos, our model extracts a 128-dimensional vector representing features of the retina as phenotypes. After training the model on 40,000 images from the EyePACS dataset, we generated phenotypes from 130,329 images of 65,629 British White participants in the UK Biobank. We conducted GWAS on these phenotypes …

Importance Of Mind-Body Medicine And Human Flourishing In The Training Of Physicians, Aviad Haramati

Marshall Journal of Medicine

No abstract provided.

Prevalence And Predictors Of Cesarean Delivery In A Tertiary Hospital In Taraba State, Nigeria, Olateju Alao Bamigbala, Ayodeji Oluwatobi Ojetunde, Maza Tanko

Tanzania Journal of Science

A cesarean section (CS) is a surgical technique in which a baby is delivered through an abdomen and uterine incision following fetal viability. It is imperative to identify the factors that influence the use of CS to reduce the needless use of this life-saving procedure and increase its availability for those who need it most. Therefore, this study assesses the prevalence and predictors of cesarean delivery in a tertiary hospital in Taraba state, Nigeria. Information of pregnant women who came for delivery to Federal Medical Center, Jalingo, Taraba state Nigeria from August 2021 to August 2023 was collected. Binary Logistic …

The Psychology And Impact Of Cheating, Jackson Smith, Hagar Ahmed, Michael Burrough, Isaac Britland, Barish Mertkolu

ENGL 1102 Showcase

This anthology discusses cheating as an idea, and its effects in a variety of different social spaces, digital and physical. We talk about how and why cheating occurs, as well as what is done to prevent it. Additionally, we discuss what more can be done to mitigate the effects that cheating has as it becomes more widespread due to advances in technology. The first topic discussed is how the architecture of educational institutions can affect cheating in school. The next topic discusses the variety of ways that players in casual and competitive eSports cheat, and what is done to prevent …

Restoring Functions Of Christian Worship: An Examination Of The Impacts Of Biblical Musical Meditation On Anxiety, Laurie P. Brooks

Doctoral Dissertations and Projects

Based on diagnostic interview data from the National Comorbidity Study Replication (NCS-R), an estimated 31.1% of U.S. adults experience anxiety at some time in their lives. This project outlines a mixed-methods research that examines the impact of music and Scripture, and illustrates the experiences of multiple individuals experiencing situational anxiety. For fifteen minutes, for seven days, the three groups listened to a cycle of three songs that depicted calming instrumental music, general worship music with promising themes, and positive lyrics or songs with lyrics based on Scripture. The three groups received varying treatments of music while completing a modified version …

Virtual Reality As An Adjunct To Behavior Therapy: A Systematic Literature Review, Alya Alharrasi

Honors Theses

The World Health Organization (WHO) projects that by 2030, mental disorders will become the primary source of global disease burden [1]. Anxiety-related disorders, including specific phobias, post-traumatic stress disorder (PTSD), and various forms of general or specific anxiety, are the most rapidly growing mental health disorders worldwide [2]. In the United States (US), over 1 in 10 American youths are experiencing depression, resulting in a severe impact on their personal, academic, or professional encounters and social engagements [3]. Similarly, anxiety disorders affect up to one-third of the US population during their lifetime [4].

Due to the growth of mental health …

Injectable And Rapidly Expandable Thrombin-Decorated Cryogels Achieve Rapid Hemostasis And High Survival Rates In A Swine Model Of Lethal Junctional Hemorrhage, Syed Muntazir Andrabi, S.M. Shatil Shahriar, Al-Murtadha Al-Gahmi, Benjamin L. Wilczewski, Mark A. Carlson, Jingwei Xie

Department of Mechanical and Materials Engineering: Faculty Publications

Effective therapies are urgently needed to stabilize patients with marginally compressible junctional hemorrhage long enough to get them to the hospital alive. Herein, we report injectable and rapidly expandable cryogels consisting of polyacrylamide and thrombin (AT cryogels) created by cryo-polymerization for the efficient management of lethal junctional hemorrhage in swine. The produced cryogels have small pore sizes and highly interconnected porous architecture with robust mechanical strength. The cryogels exhibit rapid shape memory properties and prove to be resilient against fatigue. These cryogels also show high water/blood absorption capacity, fast blood clotting effect, and enhanced adhesion of red blood cells and …

Impact Of Topical Capsaicin Cream On Thermoregulation And Perception While Walking In The Cold, Alice L. Held, Jessica L. Moler, Alejandro M. Rosales, Andrew C. Engellant

University of Montana Conference on Undergraduate Research (UMCUR)

Capsaicin, a chili pepper extract, can stimulate increased skin blood flow (SkBF) with a perceived warming sensation on application areas. Larger surface area application may exert a more systemic thermoregulatory response. Capsaicin could assist with maintaining heat transport to the distal extremities, minimizing cold weather injury risk. However, the thermoregulatory and perceptual impact of topical capsaicin cream application prior to exercise in the cold is unknown. METHODS: Following application of either a 0.1% capsaicin or control cream to the upper and lower extremities (10 g total, 40-50% body surface area), 11 participants in shorts and a t-shirt were exposed to …

The Effects Of Virtual Group Study On Class Views And Performance, W. Matt Denning, Robert S. Thiebaud, Lindy M. Rossow

Educational Practices in Kinesiology

Peer-to-peer teaching improves academic performance. During the worldwide pandemic, peer-to-peer teaching was unavailable, and feelings of isolation and loneliness increased. This study investigated the impact of virtual peer-to-peer group study on student performance and class views in a virtual, undergraduate exercise physiology course. Sixty-nine college-aged adults were randomly assigned to study with a virtual group or individually for two instructional units. Students switched groups after the first unit. For virtual group study, students met virtually for at least one hour outside of class to study course content. Those assigned to the individual study did not study virtually with classmates. Unit …

Analyzing Drosophila Melanogaster Circadian Rhythms Using Dam3 And Shiny-R Analysis, Maria Eduarda Couto Dourado, Kimberly D. Rowland

Student Publications and Presentations

Circadian rhythms are changes in behavior over a 24-hour period, that most animals experience. Light and darkness have the biggest influence on the behavior change. (U.S. DHHS). Flies reared in dark environments even more than 300 generations still have circadian rhythms (reference). This study analyzes data from the DAM, which allows us to study circadian rhythms in flies after various treatments and conditionings. Flies exposed to a dark environment for a week after two treatments were analyzed for any changes to their normal patterns. Comprehending the circadian rhythms of Drosophila is essential for grasping the molecular and genetic foundations of …

Designing, Implementing And Testing An Intervention Of Affective Intelligent Agents In Nursing Virtual Reality Teaching Simulations—A Qualitative Study, Michael Loizou, Sylvester Arnab, Petros Lameras, Thomas Hartley, Fernando Loizides, Praveen Kumar, Dana Sumilo

School of Nursing and Midwifery

Emotions play an important role in human-computer interaction, but there is limited research on affective and emotional virtual agent design in the area of teaching simulations for healthcare provision. The purpose of this work is twofold: firstly, to describe the process for designing affective intelligent agents that are engaged in automated communications such as person to computer conversations, and secondly to test a bespoke prototype digital intervention which implements such agents. The presented study tests two distinct virtual learning environments, one of which was enhanced with affective virtual patients, with nine 3rd year nursing students specialising in mental health, during …

The Grizzly, April 18, 2024, Marie Sykes, Nicolas Ungurean, Andrew J. Perez, Ellie Burns, Kathy Logan, Kate Horan, Sidney Belleroche, Renee Washart, James Rapp

Ursinus College Grizzly Newspaper, 1978 to Present

Tensions High at Congressional Town Hall • Tree Planting Ceremony to Honor Damiano Rotolo • Ursinus Hosting "Out of Darkness" Walk • Phi Kap's LLS Fundraiser • Expert Tips on Graduate School Planning: What You Need to Know • First Year Review on First-Year Housing • Every REP Matters • ReLAXing is Not an Option

Analysis Of The Neurophysiological Responses Of Lumbricina: An Invertebrate Model For Stem Education, Ragan Adkins, Bryce Allen, Michael Fultz

2024 Celebration of Student Scholarship - Poster Presentations

The Invertebrates, specifically lumbricina, can serve as a model system for science education when studying neuron viability and the impact of various drugs on conduction velocity within the nervous system. Earthworms prove to be ideal candidates due to their easily stimulated and measurable large axon bundles. Earthworms are also inexpensive, noncontroversial, and easily sedated, making them suitable for STEM learning. Each earthworm underwent a standardized anesthetization procedure with an ethanol and water mixture before being placed on a nerve bath. They were then stimulated by an electrode to gather a control action potential. By measuring the speed at which …

Acetaminophen Influences Musculoskeletal Signaling But Not Adaptations To Endurance Exercise Training, Brandon Roberts, Alyssa Geddis, Alexandra Ciuciu, Marinaliz Reynoso, Nikhil Mehta, Alyssa Varanoske, Alyssa Kelley, Raymond Walker, Rigoberto Munoz, Alexander Kolb, Jeffery Staab, Marshall Naimo, Ryan Tomlinson

Department of Orthopaedic Surgery Faculty Papers

Acetaminophen (ACE) is a widely used analgesic and antipyretic drug with various applications, from pain relief to fever reduction. Recent studies have reported equivocal effects of habitual ACE intake on exercise performance, muscle growth, and risks to bone health. Thus, this study aimed to assess the impact of a 6-week, low-dose ACE regimen on muscle and bone adaptations in exercising and non-exercising rats. Nine-week-old Wistar rats (n = 40) were randomized to an exercise or control (no exercise) condition with ACE or without (placebo). For the exercise condition, rats ran 5 days per week for 6 weeks at a 5% …

A Revamped Rat Reference Genome Improves The Discovery Of Genetic Diversity In Laboratory Rats, Tristan V De Jong, Yanchao Pan, Pasi Rastas, Daniel Munro, Monika Tutaj, Huda Akil, Chris Benner, Denghui Chen, Apurva S Chitre, William Chow, Vincenza Colonna, Clifton L Dalgard, Wendy M Demos, Peter A Doris, Erik Garrison, Aron M Geurts, Hakan M Gunturkun, Victor Guryev, Thibaut Hourlier, Kerstin Howe, Jun Huang, Ted Kalbfleisch, Panjun Kim, Ling Li, Spencer Mahaffey, Fergal J Martin, Pejman Mohammadi, Ayse Bilge Ozel, Oksana Polesskaya, Michal Pravenec, Pjotr Prins, Jonathan Sebat, Jennifer R Smith, Leah C Solberg Woods, Boris Tabakoff, Alan Tracey, Marcela Uliano-Silva, Flavia Villani, Hongyang Wang, Burt M Sharp, Francesca Telese, Zhihua Jiang, Laura Saba, Xusheng Wang, Terence D Murphy, Abraham A Palmer, Anne E Kwitek, Melinda R Dwinell, Robert W Williams, Jun Z Li, Hao Chen

Faculty, Staff and Student Publications

The seventh iteration of the reference genome assembly for Rattus norvegicus-mRatBN7.2-corrects numerous misplaced segments and reduces base-level errors by approximately 9-fold and increases contiguity by 290-fold compared with its predecessor. Gene annotations are now more complete, improving the mapping precision of genomic, transcriptomic, and proteomics datasets. We jointly analyzed 163 short-read whole-genome sequencing datasets representing 120 laboratory rat strains and substrains using mRatBN7.2. We defined ∼20.0 million sequence variations, of which 18,700 are predicted to potentially impact the function of 6,677 genes. We also generated a new rat genetic map from 1,893 heterogeneous stock rats and annotated transcription start sites …

The Experiences Of Stress And Resilience On The Allostatic Load Of Transgender And Gender Non-Binary Individuals During Secondary School: How Their Experiences Can Inform Best Practices, Kimberly Skye Ferina

Theses & Dissertations

Transgender, gender non-conforming, and gender non-binary (TGNCNB) students face many challenges in secondary school that increase their allostatic load and can lead to allostatic overload. Various aspects of their identity cultivate stress, compounded by variables that impact them throughout the day. TGNCNB youth are at a greater risk of bullying and harassment than their cisgendered peers and are at a greater risk of employing harmful mitigating behaviors and suicidal ideation. TGNCNB youth spend most of their day in the school setting, and there is limited research on this population that identifies what schools can do to support this population better. …

Colorectal Cancer Murine Models: Initiation To Metastasis, Ramesh Pothuraju, Imran Khan, Maneesh Jain, Michael Bouvet, Mokenge Malafa, Hemant K Roy, Sushil Kumar, Surinder K Batra

Faculty, Staff and Students Publications

Despite significant advancements in prevention and treatment, colorectal cancer (CRC) remains the third leading cause of cancer-related deaths. Animal models, including xenografts, syngeneic, and genetically engineered, have emerged as indispensable tools in cancer research. These models offer a valuable platform to address critical questions regarding molecular pathogenesis and test therapeutic interventions before moving on to clinical trials. Advancements in CRC animal models have also facilitated the advent of personalized and precision medicine. Patient-derived xenografts and genetically engineered mice that mirror features of human tumors allow for tailoring treatments to specific CRC subtypes, improving treatment outcomes and quality of life. To …

Promoting Nutrition Literacy In Children: A Case Study Of A Community Partnership Between A University And An Elementary School, Candise Branum

Foley Library Scholarship

Background: Health literacy outreach is commonplace within public and hospital libraries but less so in academic libraries, where it is often viewed as not integral. Academic health science libraries may collaborate with public libraries to provide public health information literacy programming or “train the trainer” sessions, but examples of academic health science librarians leading community health initiatives are still limited.

Case Presentation: This case report discusses a collaborative project between Gonzaga’s Foley Center Library, the School of Nursing and Human Physiology, and a local elementary school to promote health literacy for students and their families, led by an Academic Health …