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Oxidized Phospholipids Regulation Of The Monocyte Recruitment Parthway In Human Aortic Endothelial Cells, Piao Jian Tan

Masters Theses

Low-density lipoprotein particles in blood plasma invade the endothelium and become oxidized, creating risk of CHD associated with atherosclerosis, the main underlying condition in coronary heart disease. Oxidation products of the phospholipid 1-palmitoyl- 2-arachidonoyl-sn-glycerol-3-phosphatidylcholine (PAPC) are bioactive components of minimally oxidized LDL that stimulate endothelial cells that line the artery, leading to monocyte binding and atherosclerosis. It is hypothesized that the regulation of the monocyte recruitment pathway by these oxidized phospholipids is mediated by the binding of OxPAPC to one or more mediating proteins. Human recombinant VEGFR2, GRP78, and EP2bind to OxPNB, a biotinylated analog of OxPAPC, demonstrated using Western …

The Effect Of Color On Working Memory Performance, Michelle Galvez

HIM 1990-2015

This paper explores the effect of color on working memory performance. Interest in Baker-Miller pink surged with the finding by Schauss (1979) that it reduced aggression in aggravated detainees. However, research behind Baker-Miller pink has been influenced by biases and methodological errors. Its effects are likely overstated. Red and blue have also been studied for their effects on creativity, approach-avoidance conflict, detail-orientation, and most importantly, stress. Further research has been conducted on the effects of relaxation on cognition, with the conclusion that increased relaxation leads to improvements in working memory performance. This paper tests the effect of color on working …

Biomechanical Comparisons Of The Power Clean And Power Hang Clean Exercises At Different Relative Intensities, Jacob Troy Caldwell

Master's Theses and Doctoral Dissertations

The purpose of this study was to compare normalized peak power (PP) and peak barbell acceleration (BA) between the power clean (PC) and power hang clean (PHC) exercises among eight male weightlifters (25.5 ℗ł 2.86 yr; 85.25 ℗ł 11 kg). Biomechanical comparisons were made between both exercises at 60%, 70%, and 80% of each subject⁰́₉s one repetition maximum (1RM). When comparing both exercises for normalized PP, there was no significant difference at 60% and 70% of 1RM. At 80% 1RM, the PHC demonstrated significance (p = 0.016) with higher normalized PP when compared to the PC. When comparing both exercises …

Influence Of Native And Processed Cereal Grain Fibers On Gut Health, Junyi Yang

Department of Food Science and Technology: Dissertations, Theses, and Student Research

Cereal fibers that can be metabolized by gut microbiota have been shown to promote the growth of beneficial bacteria in the gut. Increased consumption of cereal fibers may improve host / gut microbiota interactions in obesity and other metabolic diseases by normalizing gut dysbiosis. The present dissertation describes four research projects to assess the impact of cereal dietary fibers on gut microbiota and host metabolism. In the first study, we determined the treatment temperatures for production of soluble, non-digestible, feruloylated oligo- and polysaccharides (FOPS) from maize bran and wheat bran, and determined the fermentation properties of partially purified FOPS from …

God Talk By Professors Within The Classrooms Of Public Institutions Of Higher Education: What Is Constitutionally Permissible?, Sarah Howard Jenkins, Byron R. Johnson, Otto Jennings Helwig

Akron Law Review

This essay establishes, first, the professional aspects of disclosure. Second, it defines the equipoise between the State's interest in efficiency and the teacher's interest in exercising his or her First Amendment right of expression of religious opinion on matters of public interest. Third, the essay identifies expressive activities of the teacher within the classroom that should be accorded First Amendment protection pursuant to James v. Board of Education. Fourth, the essay examines whether the professor's disclosure of personal and theological biases in a classroom constitutes state action and concludes that a professor fulfilling his or her assigned tasks within …

Effect Of Beetroot Juice On Self-Regulated, Moderate-Intensity Exercise, Jordyn N. Rienks, Andrea A. Vanderwoude, Elizabeth Maas, Zachary M. Blea, Andrew W. Subudhi

International Journal of Exercise Science

International Journal of Exercise Science 8(3): 277-286, 2015. Dietary nitrate supplementation has been shown to reduce oxygen consumption at a fixed work rate. We questioned whether a similar effect would be observed during variable work rate exercise at a specific rating of perceived exertion (RPE), as is commonly prescribed for aerobic training sessions. Using a double-blind, placebo controlled, crossover design, ten females (25 ± 3 years; VO₂peak 37.1 ± 5.3 ml/kg/min) performed two 20-min cycle ergometer trials at a constant RPE of 13 (somewhat hard) 2.5 hours following ingestion of 140 ml of concentrated beetroot juice (12.9 mmol …

Effect Of A Mindfulness Intervention On Stress And Coping Strategies In Physician Assistant Students, Mark Volpe

Yale School of Medicine Physician Associate Program Theses

Physician assistant students represent a stressed population, often with poor coping skills. Prior research amongst undergraduate and graduate students has shown that mindfulness interventions are often effective in reducing stress in the short-term. This has not been studied in physician assistant students or for long-term outcomes. We propose a randomized controlled trial to study the effects of a mindfulness intervention on short-term and long-term physician assistant student stress and coping skills. Students from three sites in Connecticut will be provided an eight week mindfulness intervention or be placed in a control group. Stress and coping skills will be measured at …

Functional Characterization Of A Cathepsin L In Drosophila Melanogaster, Qian Dong

Masters Theses & Specialist Projects

The Drosophila dorsal Air Sac Primordium (ASP) is a tracheal tube that invasively grows toward and into the wing imaginal disc. The unfolding of Drosophila wing is a process following eclosion with a cuticular bilayer replacing epithelial cells originally packing the wing. We reasoned that protease functions might be needed for the invasion of ASP into the wing imaginal disc as well as the rearrangement of epithelia cells during wing unfolding. Our study is particularly focused on understanding the role of a Cathepsin L like cysteine protease (CP1) in the development of dorsal ASP and wing development of Drosophila melanogaster. …

Touching Brains, Jason Tougaw

Publications and Research

No abstract provided.

Prediction -- The Quintessential Policy Model Validation Test, Wayne Wakeland

Complex Systems Faculty Publications and Presentations

It is essential to objectively test how well policy models predict real world behavior. The method used to support this assertion involves the review of three SD policy models emphasizing the degree to which the model was able to fit the historical outcome data and how well model-predicted outcomes matched real world outcomes as they unfolded. Findings indicate that while historical model agreement is a favorable indication of model validity, the act of making predictions without knowing the actual data, and comparing these predictions to actual data, can reveal model weaknesses that might be overlooked when all of the available …

Biology, Saint Mary's College Of California

Academic Catalog

No abstract provided.

Pre-Professional Curricula, Saint Mary's College Of California

Academic Catalog

No abstract provided.

Metagenome Sequencing Of The Hadza Hunter-Gatherer Gut Microbiota, Simone Rampelli, Stephanie L. Schnorr, Clarissa Consolandi, Silvia Turroni, Marco Severgnini, Clelia Peano, Patrizia Brigidi, Alyssa N. Crittenden, Amanda G. Henry, Marco Candela

Anthropology Faculty Research

Through human microbiome sequencing, we can better understand how host evolutionary and ontogenetic history is reflected in the microbial function. However, there has been no information on the gut metagenome configuration in hunter-gatherer populations, posing a gap in our knowledge of gut microbiota (GM)-host mutualism arising from a lifestyle that describes over 90% of human evolutionary history. Here, we present the first metagenomic analysis of GM from Hadza hunter-gatherers of Tanzania, showing a unique enrichment in metabolic pathways that aligns with the dietary and environmental factors characteristic of their foraging lifestyle. We found that the Hadza GM is adapted for …

Pleiotropic Effects Of Bitter Taste Receptors On [Ca2+]I Mobilization, Hyperpolarization, And Relaxation Of Human Airway Smooth Muscle Cells., Blanca Camoretti-Mercado, Susan H Pauer, Hwan Mee Yong, Dan'elle C Smith, Deepak A. Deshpande, Phd, Steven S An, Stephen B Liggett

Center for Translational Medicine Faculty Papers

Asthma is characterized by airway inflammation and airflow obstruction from human airway smooth muscle (HASM) constriction due to increased local bronchoconstrictive substances. We have recently found bitter taste receptors (TAS2Rs) on HASM, which increase [Ca2+]i and relax the muscle. We report here that some, but not all, TAS2R agonists decrease [Ca2+]i and relax HASM contracted by G-protein coupled receptors (GPCRs) that stimulate [Ca2+]i. This suggests both a second pathway by which TAS2Rs relax, and, a heterogeneity of the response phenotype. We utilized eight TAS2R agonists and five procontractile GPCR agonists in cultured HASM cells. We find that heterogeneity in the …

Effects Of A Chronic Low Carbohydrate High Fat Diet On Markers Of Cholesterol And Lipoprotein Metabolism In Elite Level Ultra-Endurance Male Runners, Brent C. Creighton

Doctoral Dissertations

Archival abstract submitted.

Muscle Fatigue At The End Of A Maximal Oxygen Consumption Test, Gustavo Sierra

Health, Exercise, and Sports Sciences ETDs

Fatigue is a task dependent multifactorial phenomenon, and the most common tool to analyze it is the VO2max test. The purpose of this study was to investigate if muscle is exhaustively taxed at the end of a VO2max test. This was based on data from sEMG, heart rate, and force applied to the pedals during and immediately after a VO2max test compared to an intense anaerobic test. Methods. 12 male participants (mean ± SD age = 28.09 ± 6.55 years, height = 176.7 ± 2.97 cm, weight = 73.31 ± 8.44 kg, and VO2max = 60.93 ± 9.75 mL/kg/min) were …

Suspension Model For Blood Flow Through A Tapering Catheterized Inclined Artery With Asymmetric Stenosis, Devajyoti Biswas, Moumita Paul

Applications and Applied Mathematics: An International Journal (AAM)

We intend to study a particle fluid suspension model for blood flow through an axially asymmetric but radially symmetric mild stenosis in the annular region of an inclined tapered artery and a co-axial catheter in a suitable flow geometry has been considered to investigate the influence of velocity slip at the stenotic wall as well as hematocrit, shape parameter. The model also includes the tapering effect and inclination of the artery. Expressions for the flow variables have been derived analytically and their variations with various flow parameters are represented graphically. The results for the different values of the parameters involved …

Human Olfactory Perception: A Literature Review, Catherine Jameson Lee Kelly

Loma Linda University Electronic Theses, Dissertations & Projects

There has been wide debate about the degree to which humans are impacted by olfaction. Despite former assumptions that we are dominantly visual/auditory creatures, recent studies suggest that humans are more highly macrosmatic than originally thought. Humans have demonstrated behavioral, physiological, cognitive and affective responses to olfactory stimuli even when the stimuli were perceived unconsciously. The mechanism by which humans perceive these signals is unclear; there is much debate as to whether the vomeronasal organ is functional in humans. Regardless of the mechanism of perception, it is clear olfaction is psychologically impactful for humans. The following literature review summarizes research …

Lnfluences Lmpacting The Development Of Entry-Level Master's Athletic Training Programs, Jennifer E. Deranek

Dissertations

Athletic training is an allied health profession in which individuals receive education in prevention, emergency care, clinical diagnoses, therapeutic intervention and rehabilitation for injuries and medical conditions. Currently, the route for an individual to become a certified athletic trainer is to graduate from an institution accredited by the Commission on Accreditation of Athletic Training Education (CAATE). Most commonly, entry-level education for athletic trainers is gained at the 331 institutions that host a bachelor’s level professional program. However, there is a recent desire to change the educational requirements and to require a professional master’s degree. If the degree change would occur, …

A Pill, A Cup Of Tea, And A Cigarette: Male Body In Egypt At The Age Of Viagra, Youssef Ramez Boktor

Theses and Dissertations

From disciplined self to ‘Viagra-self’ is a transition that men experience in the ‘age of Viagra’. My field work looks at how chemically enhanced sexual performance has been normalized in a specific way that signifies the deliberate control over human’s sexual performance. How the sexual relationship - in a specific socio-cultural context - becomes the most available path to seek happiness ‘inbesat’, in low priced form. The ‘Viagra-self’ learns how to invest in parts of the body in order to perform, to experience how the chemically enhanced body can proclaims control and time (sexual) performance. The Viagra-self, in the era …

Advancing The Early Detection Of Atrial Fibrillation Through In Silico Tissue Modeling, Michael Herringshaw

Electronic Theses and Dissertations Archive

Atrial fibrillation (AF) is a widely prevalent arrhythmia which affects approximately 4.5 million people in Europe and the US, reducing quality of life and increasing risk of stroke and death. Considerable research effort is currently directed to the arrhythmia because the mechanisms causing its initiation, maintenance, and termination are not well understood. This study addresses, at a tissue level, the basic descriptors of atrial fibrillation, known causes, and a model to utilize in analyzing heart wave characteristics such as propagation velocity, action potential duration and others for potential use in developing early detection methods of AF. The tissue model methodology, …

Effects Of Ibuprofen And Caffeine Concentrations On The Common Bed Bug (Cimex Lectularius L.) Feeding And Fecundity, Ralph B. Narain, Shripat T. Kamble

Department of Entomology: Faculty Publications

Bed bugs are ectoparasites of humans and require a blood meal for their growth and reproduction. Since humans consume Ibuprofen as pain medication and drink coffee (caffeine), bed bugs are likely to acquire these drugs through blood feeding. In this study, we determined the biological effects of Ibuprofen and caffeine on bed bug feeding, fecundity and egg hatch. Five concentrations of Ibuprofen and caffeine were incorporated into reconstituted human blood (RHB). Control treatment had no Ibuprofen or caffeine. Each treatment had six replications. Groups of 20 adult bed bugs (10 males: 10 females)/treatment/replication were pre-weighed, allowed to feed for 45 …

Genetic And Cellular Studies Of The Podocyte In Focal Segmental Glomerulosclerosis, Haiyang Yu

Arts & Sciences Graduate Student Theses and Dissertations

The podocyte forms the outer layer of the filtration barrier in the glomerulus to prevent albumin leakage. Podocyte damage leads to focal segmental glomerulosclerosis (FSGS), a leading cause of chronic kidney disease. The cause of the majority of FSGS cases is unknown and referred to as sporadic FSGS. Genetic studies have identified genes as monogenic causes of FSGS in patients with a strong family history, but these cases account for only a small proportion of the FSGS population. Whether genetic susceptibility contributes to sporadic FSGS and which cellular process in the podocyte initiates the pathogenesis of FSGS are important questions …

The Interaction Of Glutathione With Platinum, And The Role Of Ph In Altering Ligand Formation Between Platinum And N-Acetylcysteine, Kyle B. Mann

Mahurin Honors College Capstone Experience/Thesis Projects

Cisplatin is an important anti-cancer drug. Structurally, cisplatin is a coordination complex, which means that it has a central metallic atom: platinum. Side interactions prevent cisplatin from effectively treating cancerous cells by reaction with DNA. Cisplatin has a high rate of forming protein adducts, primarily with sulfur containing amino acids. To better understand how cisplatin interacts with sulfur containing amino acids in the body, a platinum compound with an ethylenediamine ligand attached was reacted with N-acetylcysteine and glutathione. The reactions of cysteine with platinum were performed at three pH values: 7.0, 8.5, and 10. NMR spectroscopy was used to examine …

The Effect Of Heat Acclimation On Hand Cooling Efficacy During Exercise Heat Stress, Elizabeth Adams

Master's Theses

The Effect of Heat Acclimation on Hand Cooling Efficacy During Exercise Heat Stress

Adams EL, Vandermark LW, Pryor JL, Pryor RR, Vanscoy RM, Denegar CR, Huggins RA, Armstrong LE, Casa DJ. Korey Stringer Institute, Department of Kinesiology, University of Connecticut, Storrs, CT.

CONTEXT: Heat acclimation (HA) and body cooling during exercise in the heat both help to mitigate the rise in body temperature; however, the effects of HA and hand cooling combined remain unexplored. OBJECTIVE: To determine the separate and combined effects of HA and hand cooling efficacy, during and after exercise in the heat. DESIGN: Randomized, counterbalanced, crossover design. …

Human Factors In High-Altitude Mountaineering, Christopher D. Wickens, John W. Keller, Christopher Shaw

Journal of Human Performance in Extreme Environments

We describe the human performance and cognitive challenges of high altitude mountaineering. The physical (environmental) and internal (health) stresses are first described, followed by the motivational factors that lead people to climb. The statistics of mountaineering accidents in the Himalayas and Alaska are then described. We then present a detailed discussion of the role of decision-making biases in mountaineering mishaps. We conclude by discussing interpersonal factors, adaptation, and training issues.

Applications Of Organic Probes For Imaging And Analysis Of Different Cancer Cell Models, Hong Guan

Theses and Dissertations

Novel techniques for better studying cancer cell behavior and progression are extremely important. Our lab is interested in synthesizing specifically designed organic reagents and applying them in the studies of cancers. In this dissertation, we used organic probes to investigate cancer cells in the following topics: determination of amino acid concentration in different types of cancers, tumor toxicity of organic probes towards HER2 positive breast cancer cells, glycoproteins identification in breast cancer cells and development of enzyme activity assay for colon cancer cells.

The first chapter was focused on the determination of cysteine/homocysteine concentrations using turn-on sensors in cancer cells. …

Thin Film Based Biocompatible Sensors For Physiological Monitoring, Yihao Zhu

Theses and Dissertations

The development and evolution of physiological sensors, from wearable to implantable, has enabled long term continuous physiological monitoring, making possible for the out-of-clinic treatment and management of many chronic illnesses, mental health issues and post-surgery recovery. This technology advance is gradually changing the definition of health care and the way it is delivered, from clinic/emergency room to patient’s own environment. In this dissertation, three general types of sensors have been proposed for physiological monitoring of blood pressure, oxygen content and electrolyte ion concentration level in human body, respectively. The study proved the device concepts and shows promising results with the …

Evidence For Biphasic Effects And Differential Expression Of Melatonin (Mlt) Receptors In Oral Squamous Cell Carcinomas, M. Farnoush, D. Swint, Karl Kingsley

Dental Medicine Faculty Research

No abstract provided.

The Physiological Response On Immersion In Cold Water And The Cooling Rates On Swimming In A Group Of Children Aged 10 – 11 Years, Flora Bird, Jim House, Michael J. Tipton

International Journal of Aquatic Research and Education

Swimming is a popular sport in the United Kingdom (UK); however, cold water immersion often found in open waters in the UK is not without increased risk. Drowning is among the leading cause of accidental death in 1-14 year-olds in most countries. We examined whether children and adults exhibit similar cold shock responses; their rate of cooling while swimming; and subjective recognition of cooling. Nineteen children aged 10-11 years voluntarily undertook a 5 min static immersion in 15 °C (59 °F) water. Ten of them then completed a swim of up to 40 min. Resting heart rate, respiratory frequency and …