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Valveless Pumping: The Reflected Pulse Wave Hypothesis, Charles F. Babbs

Weldon School of Biomedical Engineering Faculty Working Papers

No abstract provided.

Mechanisms Of Hormonal Regulation Of Invasiveness And Metastasis Of Luminal Breast Cancer, Thomas Mcfall

Wayne State University Dissertations

ABSTRACT

MECHANISMS OF HORMONAL REGULATION OF INVASIVENESS AND METASTASIS OF LUMINAL BREAST CANCER

By

THOMAS MCFALL

December 2017

Advisor: Dr. Manohar Ratnam

Major: Cancer Biology

Degree: Doctor of Philosophy

Over 20% of breast cancer cases present with distal metastasis and they are predominantly of luminal subtypes. As luminal breast cancer is relatively indolent, it is believed that progression to metastasis must occur over many years, generally well into post-menopausal years. Unfortunately, very little is known about the mechanisms by which these hormone receptor positive tumors metastasize, likely in part due to their slow metastatic rates in animal model systems as …

Stable Isotope Analysis Of The Dietary Habits Of A Greek Community In Archaic Syracuse (Sicily): A Pilot Study, Davide Tanasi, Robert Tykot, Andrea Vianello, Stephan Hassam

History Faculty Publications

The study and reconstruction of ancient dietary habits has become a very significant topic in archaeological research. Most chemical analysis studies for diet at Greek sites are limited to prehistory, with very few examples of studies for the Classical period. This paper represents a pilot study of stable isotope analysis carried out on a group of 15 individuals selected among the population interred in the Archaic necropolis of Scala Greca at Syracuse (Sicily), a cemetery discovered in 2010-2011. Based on the funerary assemblages and certain features such as shape, dimensions, coverage system and architectural features, a preliminary distinction has been …

Hydrogen Sulfide Regulation Of Kir Channels, Junghoon Ha

Theses and Dissertations

Inwardly rectifying potassium (Kir) channels establish and regulate the resting membrane potential of excitable cells in the heart, brain and other peripheral tissues. Phosphatidylinositol- 4,5-bisphosphate (PIP2) is a key direct activator of ion channels, including Kir channels. Gasotransmitters, such as carbon monoxide (CO), have been reported to regulate the activity of Kir channels by altering channel-PIP2 interactions. We tested, in a model system, the effects and mechanism of action of another important gasotransmitter, hydrogen sulfide (H2S) thought to play a key role in cellular responses under ischemic conditions. Direct administration of sodium hydrogen sulfide (NaHS), as an exogenous H2S source, …

Inhibition Of Oxidative And Conjugative Metabolism Of Buprenorphine Using Generally Recognized As Safe (Gras) Compounds Or Components Of Dietary Supplements, Neha V. Maharao

Theses and Dissertations

This dissertation aimed at developing an inhibitor strategy to improve the oral bioavailability (F_oral) and systemic exposure (AUC_∞) of buprenorphine (BUP) as well as reduce the variability associated with them. Twenty-seven generally recognized as safe (GRAS) compounds or dietary substances were evaluated for their potential to inhibit the oxidative and conjugative metabolism of BUP, using pooled human intestinal and liver microsomes. In both the organs, oxidation appeared to be the major metabolic pathway with a 6 fold (intestine) and 4 fold (liver) higher intrinsic clearance than glucuronidation. Buprenorphine was predicted to show low and variable F …

Puzzled Representations: Popular Media And How Educators Come To Know Autism, Vanessa N. Keener

College of Graduate Studies: Theses & Dissertations

People learn about the world through popular culture. Popular culture media representations of autism can be found in TV, film, literature, Internet media, advertisements, and more. This study employed a quantitative correlational design to survey 273 Georgia educators regarding their perceptions of autism, including knowledge about autism, best practices for teaching students labeled as having autism, perceived positivity and accuracy of popular media representations of autism, as well as participant identification with popular media representations of autism and personal characteristics (i.e., age, sex, level of education, type of degree, years of teaching experience, professional and personal experiences). Six major findings …

Neurosecurity For Brainware Devices, Brian Cusack, Kaushik Sundararajan, Reza Khaleghparast

Australian Information Security Management Conference

Brainware has a long history of development down into the present day where very simple and usable devices are available to train for the control of games and services. One of the big areas of application has been in the health sciences to provide compensatory control to humans who may lack the usual capabilities. Our concern has been the protection of information in brainware so that a human intention may have confidentiality, integrity, and accessibility to the required implementation mechanisms for services. The research question was: What are the consequences of security failure in brainware? Our research tested a brainware …

Error Aggregation In The Reengineering Process From 3d Scanning To Printing, Jennifer G. Michaeli, Matthew C. Degroff, Roman C. Roxas

Engineering Technology Faculty Publications

This work aims to study the aggregation of dimensional errors in the reengineering processes using 3D scanning and printing without initial design drawings. A 57-tooth spur gear is used as an example to facilitate the discussion. Two approaches are investigated. The first one builds the gear model based upon measurement taken from a caliper, and the second approach uses a 3D scanner to collect geometry data. Dimensional errors in each stage of these two approaches are investigated. Particular attention is paid to the geometry data flow in the reengineering process from data acquisition and editing to model construction. Recommendations are …

Systematic Review Of Countermeasures To Minimise Physiological Changes And Risk Of Injury To The Lumbopelvic Area Following Long-Term Microgravity, Andrew Winnard, Mona Nasser, Dorothee Debuse, Maria Stokes, Simon Evetts, Mick Wilkinson, Julie Hides, Nick Caplan

More Faculty of Health Research

No abstract provided.

Biom 3110: Medical Physiology (Syllabus), Bradford D. Pendley

Biomedical Engineering Syllabi Archive

Course Description: Basic principles of human physiology and how these are applied in medicine and biomedical engineering problem and devices; physiological principles using appropriate mathematical and engineering models to construct an understanding of how the body works as an integrated system.

Computational Fluid Dynamics In A Terminal Alveolated Bronchiole Duct With Expanding Walls: Proof-Of-Concept In Openfoam, Jeremy Myers

Theses and Dissertations

Mathematical Biology has found recent success applying Computational Fluid Dynamics (CFD) to model airflow in the human lung. Detailed modeling of flow patterns in the alveoli, where the oxygen-carbon dioxide gas exchange occurs, has provided data that is useful in treating illnesses and designing drug-delivery systems. Unfortunately, many CFD software packages have high licensing fees that are out of reach for independent researchers. This thesis uses three open-source software packages, Gmsh, OpenFOAM, and ParaView, to design a mesh, create a simulation, and visualize the results of an idealized terminal alveolar sac model. This model successfully demonstrates that OpenFOAM can be …

ผลฉับพลันของการออกกำลังกายแบบแอโรบิคระหว่างปริมาณออกซิเจนปกติและปริมาณออกซิเจนต่ำความดันบรรยากาศปกติที่มีต่อชีวกลศาสตร์ของการขยายทรวงอกขณะหายใจ, ต้อง คงวิเศษ

Chulalongkorn University Theses and Dissertations (Chula ETD)

วัตถุประสงค์: เพื่อศึกษารูปแบบการหายใจจากการเปลี่ยนแปลงปริมาตรทรวงอกทั้ง 4 ส่วน ได้แก่ ทรวงอกส่วนบน (Superior thoracic: ST) ทรวงอกส่วนล่าง (Inferior thoracic: IT) ช่องท้องส่วนบน (Superior abdomen: SA) และ ช่องท้องส่วนล่าง (Inferior abdomen: IA) หลังการออกกำลังกายแบบแอโรบิกระหว่างสภาวะออกซิเจนปกติ และสภาวะออกซิเจนต่ำ ความดันปกติ (ปริมาณ O2 15%) วิธีดำเนินการวิจัย: กลุ่มตัวอย่างที่ใช้ในการวิจัยครั้งนี้เป็นนิสิตนักศึกษา และนักกีฬาสมัครเล่นชมรมฟุตซอล จำนวน14 คน อายุ 18-25 ปี มีอายุเฉลี่ย 19.93 ± 1.14 ปี ส่วนสูงเฉลี่ย 173.71± 4.65 ซม น้ำหนัก 63.79 ± 7.28 kg เก็บข้อมูลโดยการวิเคราะห์จากภาพ 3 มิติ โดยทำการติดตั้ง Marker บริเวณช่วงลำตัวทั้งหมด 30 จุด บันทึกภาพรูปแบบการหายใจ ก่อน และหลังการออกกำลังกายทันทีโดยกล้องความเร็วสูง จำนวน 6 ตัว วิเคราะห์ข้อมูลโดยโปรแกรมวิเคราะห์การเคลื่อนไหว Qualisys Motion Capture System เพื่อนำมาคำนวณการเปลี่ยนแปลงปริมาตรหลังการออกกำลังกายแบบแอโรบิก ในสภาวะออกซิเจนปกติ และสภาวะออกซิเจนต่ำ ความดันปกติ ในแต่ละส่วน เปรียบเทียบผลการวิจัยก่อน-หลังการฝึก และ ระหว่างสภาวะ โดยใช้ pair t- test กำหนดระดับความมีนัยสำคัญทางสถิติที่ p-value ≤ 0.05 ผลการวิจัย: หลังออกกำลังกายแบบแอโรบิก ในสภาวะออกซิเจนต่ำความดันบรรยากาศปกติ พบว่าความจุปอดเต็มที่ (Vital Capacity: VC) ของ IT, SA และ IA มีปริมาตรเพิ่มขึ้นอย่างมีนัยสำคัญ และเมื่อวิเคราะห์ปริมาตรความจุหายใจเข้า (Inspiratory …

Mathematical Models For Treatment Time Of Pathogenic Infection In Blood After Antibiotics Administration, Panit Suavansri

Chulalongkorn University Theses and Dissertations (Chula ETD)

The objective in this thesis is to create a mathematical model to predict the period of time needed to clear out the pathogens from the bloodstream after the patient receives certain antibiotics. The result will lead to the time where the drug administration can be terminated. This research is to compute the densities of bacteria and malaria in bloodstream at any given time and to compare this level with the actual results of the patient's blood sampling, which was sent to the laboratory for investigation. The laboratory process of the blood sampling will usually take more than 2-3 days to …

Glutamine Transporters In Human Hepatocellular Carcinoma And In The Emt6 Mammary Tumor And Adjacent Stroma In The Syngeneic Balb/C Mouse Model, Clare Kron

Graduate Research Theses & Dissertations

Human hepatocellular carcinoma (HCC) is an increasing threat worldwide due to cirrhosis of the liver developing from viral hepatitis and non-alcoholic steatohepatitis (NASH). Breast cancer is the second leading cause of cancer death in American women, with the most intractable type classified as triple negative. Both cancers depend on glutamine as the major oxidizable substrate for tumor growth, therefore, identification of glutamine transporters and transporter activity is of vital importance in the development of treatment options. It is well documented that ASCT2 is the major glutamine transporter in both cancers but little is known regarding the relative amounts of additional …

Vmed 646: Animal Physiology Ii—A Peer Review Of Teaching Project Benchmark Portfolio, Renee M. Mcfee

UNL Faculty Course Portfolios

This Peer Review of Teaching Project portfolio focuses on the Animal Physiology II course which is required for first year veterinary medicine students. Weekly quizzes assess baseline knowledge and had been administered individually and in groups. I hypothesized the discontinuation of group quizzes would increase student effort when preparing for quizzes. Unit exams involve scenario-based questions and require students to apply information. I hypothesized the implementation of group exams would help under-performing students improve their ability to apply information they had learned. Exams were still taken individually prior to being taken in groups to encourage adequate preparation. Student impacts were …

Shinrin-Yoku (Forest Bathing) And Nature Therapy: A State-Of-The-Art Review, Margaret M. Hansen Edd, Msn, Rn, Reo Jones, Kirsten Tocchini

Nursing and Health Professions Faculty Research and Publications

Background: Current literature supports the comprehensive health benefits of exposure to nature and green environments on human systems. The aim of this state-of-the-art review is to elucidate empirical research conducted on the physiological and psychological effects of Shinrin-Yoku (or Forest Bathing) in transcontinental Japan and China. Furthermore, we aim to encourage healthcare professionals to conduct longitudinal research in Western cultures regarding the clinically therapeutic effects of Shinrin-Yoku and, for healthcare providers/students to consider practicing Shinrin-Yoku to decrease undue stress and potential burnout. Methods: A thorough review was conducted to identify research published with an initial open date range …

Development Of A 3d Microphysiologic Liver For Drug Toxicity Testing, Maryrose Kammer

All ETDs from UAB

Development of almost all novel effective drug compounds is immensely expensive and time consuming. The process is slowed by the ineffectiveness of current toxicity testing methods, with 80% of drugs undergoing late-stage failure in clinical trials or post-market withdrawal. The leading cause of these failures and withdrawals is due to drug-induced liver injury. Much of drug metabolism occurs in the liver, but there are incredible differences among the metabolic pathways in humans, animal models, and two-dimensional testing platforms. Thus, the current methods are limited to accurately predict in vivo metabolic response of a novel compound. Three dimensional (3D) in vitro …

The Role Of Hur In Astrocytes In Spinal Cord Injury, Thaddaeus Kwan

All ETDs from UAB

Neuroinflammation is a defining event during the acute phase of spinal cord injury (SCI). The inflammatory cascade is initiated by activated glial cells such as astrocytes and microglia in the milieu of the injured tissue through release of pro-inflammatory cytokines, matrix metalloproteinases, and reactive oxygen species. These soluble factors produce cytotoxicity to neurons and other cells either directly or indirectly by promoting permeabilization of the blood-spinal cord barrier, edema and subsequent ischemia. These factors also serve to recruit and activate additional glia and peripheral immune cells. The mRNAs of many of these soluble factors such as TNFα, IL-1β, CXCL1, and …

The Child As Risk: Precocious Girls And Sexual Consent In Late Victorian Britain, Victoria Bates

SOLON Law, Crime and History (previously SOLON Crimes and Misdemeanours: Deviance and the Law in Historical Perspective)

The figure of the precocious girl pervaded Victorian culture, yet is poorly understood. This article focuses on concerns about sexual precocity and their influence on age-of-consent debates in the 1880s. It shows that even this single form of precocity (sexual) took multiple forms and was a malleable concept, often used selectively in parliamentary debates to suit particular agendas. These different uses of precocity did have in common, however, a tendency to be situated against the normal as 'ideal' rather than only statistically 'typical'. As precocity was generally measured against the ideal sexual development and behaviour of respectable North European girls, …

Iraqi Refugees And Cultural Humility: A Mental Health Professional Training Program, Megan Brunmier Marsh

Antioch University Dissertations & Theses

This paper describes the development of a thorough nine-hour professional training program targeting the cultural humility of mental health clinicians who are treating new Iraqi refugee communities. I used the 15-step evidence-based Comprehensive Program Development Model created by Calley (2009) for the design of the structure, curriculum, and materials for this proposed program (Calley, 2011). The training program is informed by conceptual frameworks of cultural competence and humility, ecological systems theory, and social justice with goals of (a) exploring clinicians’ cultural attitudes in order to improve self-awareness at multiple levels (e.g., physiological, psychological, interpersonal), (b) increasing clinicians’ knowledge about Iraqi …

An Enhanced Spring-Particle Model For Red Blood Cell Structural Mechanics: Application To The Stomatocyte–Discocyte– Echinocyte Transformation, Mingzhu Chen, Fergal Boyle

Articles

Red blood cells (RBCs) are the most abundant cellular element suspended in blood. Together with the usual biconcave-shaped RBCs, i.e., discocytes, unusual-shaped RBCs are also observed under physiological and experimental conditions, e.g., stomatocytes and echinocytes. Stomatocytes and echinocytes are formed from discocytes and in addition can revert back to being discocytes; this shape change is known as the stomatocyte–discocyte–echinocyte (SDE) transformation. To-date, limited research has been conducted on the numerical prediction of the full SDE transformation. Spring- particle RBC (SP-RBC) models are commonly used to numerically predict RBC mechanics and rheology. However, these models are incapable of predicting the full …

Wind Turbine Noise And Wind Speed Prediction, Tyler H. Blanchard

College of Graduate Studies: Theses & Dissertations

In order to meet the US Department of Energy projected target of 35% of US energy coming from wind by 2050, there is a strong need to study the management and development of wind turbine technology and its impact on human health, wildlife and environment. The prediction of wind turbine noise and its propagation is very critical to study the impacts of wind turbine noise for long term adoption and acceptance by neighboring communities. The prediction of wind speed is critical in the assessment of feasibility of a potential wind turbine site. This work presents a study on prediction of …

Bulletin Of Yale University School Of Nursing 2017-2018, Yale School Of Nursing

Yale School of Nursing Bulletins and Catalogues

Series 113, Number 15

September 5, 2017

Nitrosative Stress Sensing In Porphyromonas Gingivalis: Structure And Function Of The Heme Binding Transcriptional Regulator Hcpr, Benjamin R. Belvin

Theses and Dissertations

Porphyromonas gingivalis, a Gram negative anaerobe implicated in the progression of periodontal disease, is capable of surviving and causing infection despite high levels of reactive nitrogen species found in the oral cavity due to its efficient nitrosative stress response. HcpR is an important sensor-regulator that plays a vital step in the initiation of the nitrosative stress response in many Gram negative anaerobic bacteria. We employ a combination of X-ray crystallography, SAXS, resonance Raman spectroscopy, UV-Vis spectroscopy, and molecular biology techniques to better understand this key regulator. Knockout of the hcpR gene in W83 P. gingivalis results in the inability of …

Issues Related To Implementing High-Fidelity Simulation In A Nursing Program, Sherry Rene Ray

Walden Dissertations and Doctoral Studies

Due to the shortage of clinical sites, nursing educators, deans, and directors are compelled to implement alternative clinical solutions such as high-fidelity simulation (HFS). The problem is that nursing educators are often not prepared to implement HFS as a teaching strategy. Faculty readiness is imperative for a successful simulation program and student outcomes. Therefore, the purpose of this study was to investigate the perceptions and practices of faculty, deans, and directors on the implementation of HFS across the nursing curriculum. Kolb's experiential learning theory provided the theoretical support for both the teaching and learning required by faculty for a successful …

Employee Lived Experiences And Initiative Success In Arkansas Quality Award Recipient Organizations, Carol Barton

Walden Dissertations and Doctoral Studies

Businesses with failed quality initiatives lose revenue, experience high expenses, and have fewer market opportunities. Researchers attribute failed quality initiatives to human and social factors. The purpose of this phenomenological study was to explore the lived experiences of employees in companies that received an Arkansas Governor's Quality Award between 2010 and 2015. No one knows how employees' experiences contribute to successful quality initiatives, or how their stories about their experiences influence quality management and continuous improvement. The conceptual framework consisted of Weick's theory of sense-making and Deming's system of profound knowledge. Data were collected via semistructured interviews with 11 participants …

Using Nursing Simulation To Improve Early Recognition Of Emergent Situations, Carlene Blais

Walden Dissertations and Doctoral Studies

Nurses' ability to recognize and respond to postoperative patients who require emergent medical care and need immediate assistance during a code blue in the first 10 minutes is essential to improve patient outcomes. This is particularly important for the project site, a 44-bed inpatient surgical specialty hospital located in the Northeast, providing care for patients with head and neck cancer, as the hospital does not have an internal code blue response team. An adjacent facility responds to all code blue emergencies and takes approximately 10 minutes for the team to respond. The purpose of this DNP project was to develop …

Evaluating Student Use Patterns Of Streaming Video Lecture Capture In A Large Undergraduate Classroom, Nathan E. Whitley-Grassi

Walden Dissertations and Doctoral Studies

Large classes that allow smaller amounts of instructor-student interaction have become more common in today's colleges. The best way to provide needed opportunities for students to overcome this lack of interaction with instructors remains unidentified. This research evaluated the use of video lecture capture (VLC) as a supplemental method for teacher-student interaction and what, if any, impact it and attendance have on student performance in large lecture courses. This ex post facto study conducted at a Northeastern research university utilized cognitive and andragogical frameworks to examine the relationships between the independent variables frequency of video viewing, quantity of videos viewed, …

Self Reported Knowledge Of Concussion Symptoms And Management By Middle And High School Club Lacrosse Coaches, Logan Ellis

Graduate Student Theses, Dissertations, & Professional Papers

TITLE: Self-reported knowledge of concussion symptoms and management by middle and high school club lacrosse coaches

AUTHORS: Logan Ellis

BACKGROUND: With an increase in sport participation across all levels, concussion prevalence has increased as well as reliance on coaches to recognize a concussed player. Little research has been done investigating how effective our current educational materials are with Lacrosse coaches of grades 6-12.

STUDY DESIGN: Cross- Sectional

LEVEL of EVIDENCE: Level 4

METHODS: Self-administered, online survey that included closed ended questions regarding recognition of signs and symptoms, consequences of inappropriate care, perception of own knowledge, …

Surface Enabled Lab-On-A-Chip (Loc) Device For Protein Detection And Separation, Zhichao Wang

Dissertations, Master's Theses and Master's Reports

Sensitive and selective chemical/biological detection/analysis for proteins is essential for applications such as disease diagnosis, species phenotype identification, product quality control, and sample examination. Lab-on-a-chip (LOC) device provides advantages of fast analysis, reduced amount of sample requirements, and low cost, to magnificently facilitate protein detection research. Isoelectric focusing (IEF) is a strong and reliable electrophoretic technique capable of discerning proteins from complex mixtures based on the isoelectric point (pI) differences. It has experienced plenty of fruitful developments during previous decades which has given it the capability of performing with highly robust and reproducible analysis. This progress has made IEF devices …