Digital Commons Network^™

Influence Of Dietary Nitrate Supplementation On Local Sweating And Cutaneous Vascular Responses During Exercise In A Hot Environment., T Amano, D Okushima, Bc Breese, S Bailey, S Koga, N Kondo

School of Biomedical Sciences

No abstract provided.

Education On The Inside: Incarcerated Students' Perceptions Of Correctional Education Programs, Stephanie Cage

Electronic Theses and Dissertations Archive

The United States has alarmingly high incarceration and recidivism rates. Many of those incarcerated have less education than their general population counterparts. Correctional education programs have a proven ability to reduce incarceration and recidivism rates by helping rehabilitate people. Current research on incarcerated students primarily focuses on the external benefits of correctional education programs such as recidivism. A limited amount of research is represented in the literature on incarcerated students’ perceptions about their academic experiences. The purpose of this study was to explore incarcerated students’ perceptions regarding their correctional education experiences. The study particularly investigated students at a Louisiana correctional …

Fluid Flow In A Krogh Cylinder: A Model For A Single Capillary And Surrounding Tissue, Xianjie Qiu

Masters Theses

"A model describing the flow of plasma from the capillaries to the interstitial space in the extravascular tissue and back into the capillaries is constructed and solved. The flow through the tissue or the interstitial spaces is described by the Brinkman equation for porous medium, modified to account for the presence of cells considered as spheres. The flow of blood through the capillaries is considered to be that of a Newtonian fluid. The flow between capillary and tissue is coupled by the permeability of the capillary wall. The nature of flow and its magnitude was found to be highly dependent …

An Experimental Protocol To Model Recovery Of Anaerobic Work Capacity, Vijay Sarthy M. Sreedhara, Gregory M. Mocko, Randolph Hutchison

Health Sciences Publications

Models of fatigue are based on physiological parameters such as Critical Power (CP) and Anaerobic Work Capacity (AWC). CP is a theoretical threshold value that a human can generate for an indefinite amount of time and AWC represents a finite expendable amount of anaerobic energy at intensities above CP. There is an increasing interest in developing mathematical models of energy expenditure and recovery for athletic training and human performance. The objective of this research is to propose and validate a model for recovery of AWC during a post exertion recovery interval of cycling. A cycling …

An Analysis Of Certified Athletic Trainers’ Ability To Provide High-Quality Cardiopulmonary Resuscitation (Cpr) Over Hockey Shoulder Pads, Adam Gregory Estabrooks

Health Nutrition and Exercise Science

Certified Athletic Trainers (ATCs) are expected to perform CPR for athletes regardless of whether the athlete is wearing protective equipment. The goal of this research was to determine /if ATCs were able to/ deliver high-quality CPR over hockey shoulder pads. Fifty ATCs completed CPR according to 2015 AHA guidelines on a medium-fidelity manikin, which had been fitted with hockey shoulder pads. CPR quality was measured with the Resusci Anne Wireless SkillReporter. CPR data included the following dimensions of compressions: overall score, mean rate, chest compression fraction, mean depth, % chest recoil, and % compressions with appropriate depth. Data were analyzed …

Differentiating Human Populations Based On K-Mer Classification Of Hand Bacteria, Thrisha Doppala

Graduate Theses, Dissertations, and Problem Reports (ETD)

Bacterial communities found in and on the human body are not only used in studying human health conditions but are also effective in differentiating individuals due to their distinct profiles. Human palm regions harbor relatively more diverse bacterial communities and are indicative of population groups, life styles, geographic locations, age groups and health conditions. Sequences extracted from hypervariable region V3 of the 16S rRNA bacterial gene of hand bacterial samples from 9 different population groups were classified into Operational Taxonomic Units (OTU) with GreenGenes reference taxonomy using RDP (Ribosomal Database Project) classifier. Frequencies of identified OTUs were used to study …

Establishment Of A Human Ipsc- And Nanofiber-Based Microphysiological Blood–Brain Barrier System, Dianjun Qi, Shaohua Wu, Haishuang Lin, Mitchell A. Kuss, Yuguo Lei, Alexey Krasnoslobodtsev, Shaheen Ahmed, Chi Zhang, Hyung Joon Kim, Peng Jiang, Bin Duan

Department of Chemical and Biomolecular Engineering: Faculty Publications

The blood–brain barrier (BBB) is an active and complex diffusion barrier that separates the circulating blood from the brain and extracellular fluid, regulates nutrient transportation, and provides protection against various toxic compounds and pathogens. Creating an in vitro microphysiological BBB system, particularly with relevant human cell types, will significantly facilitate the research of neuropharmaceutical drug delivery, screening, and transport, as well as improve our understanding of pathologies that are due to BBB damage. Currently, most of the in vitro BBB models are generated by culturing rodent astrocytes and endothelial cells, using commercially available transwell membranes. Those membranes are made of …

Correlating Residual Stress With Personal And Professional Characteristics In Aircraft Pilots, Erik Eckblad

Walden Dissertations and Doctoral Studies

Every day aircraft pilots must successfully resolve significant inflight situations and then manage the possibility of residual psychological and physiological stress. Previous research has shown primary attention is given to presignificant event training and stress management, however there remains an important gap in the current literature regarding postsignificant event stress within the aviation profession. The purpose of this cross-sectional quantitative study was to use the observational lens of stress theory and survey U.S. pilots who have experienced an inflight emergency, looking for correlation between factors such as age, gender, flight experience, and training against a pilot's self-reported level of residual …

Triple-Helicate Self-Assembly, Dynamics, And Anion Binding Of Halogen-Bonding M-Arylene-Ethynylene Oligomers, Casey John Massena

Graduate Student Theses, Dissertations, & Professional Papers

The form and function of biopolymers depend on the precise folding and organization of vast arrays of chemical groups. Hence, the simple yet elegant helix is one of the most pervasive structural elements in nature. Moreover, given the ubiquity and importance of anions, anion-interfacing helical structures hold promise as useful, stimuli-responsive supramolecules. Like metals, anions can powerfully coordinate organic ligands and promote helical self-assembly. However, anion coordination is far less understood than that of metals. Halide ions are an especially challenging target due to their small size, low charge, and variable coordination number/geometry. This work presents a new strategy that …

Impact Of Biobanks On Research Outcomes In Rare Diseases：A Systematic Review, Monique Garcia

Theses: Doctorates and Masters

Rare diseases (RDs) are a global priority yet are still under researched. When combined, RDs are common, with individual diseases numbering approximately 5,000-8,000, equating to approximately 7% of the population in Europe. Extrapolating this figure for Australia suggests that about 1.2 million people are affected by RDs, with about 400,000 of those being children. The WA Rare Diseases Strategic Framework 2015-2018, the first strategy for rare diseases in Australia, recognises that in order to alleviate the significant burden of rare diseases, innovative translational tools that facilitate research into new diagnostic and therapeutic strategies should be given priority.

Registries facilitate clinical, …

The Protective Effects Of Chrysin And Flunixin Meglumine Against Excess Copper In Male Rats, Pinar Tatli Seven, Burcu Gül Baykalir, İsmai̇l Seven, Tuba Parlak Ak, Neşe Başak Türkmen, Hakan Güllüoğlu

Turkish Journal of Veterinary & Animal Sciences

Thirty-six Sprague Dawley male rats were housed in individual cages and randomly divided into six groups: control, copper sulfate (Cu; 500 ppm body weight (BW)/day), flunixin meglumine (FM; 2.2 ppm BW/day), chrysin (chrysin; 50 ppm BW/day), copper sulfate + FM (Cu + FM; 500 ppm BW/day of copper sulfate and 2.2 ppm BW/day of FM), and copper sulfate + chrysin (Cu + Chrysin; 500 ppm BW/day of copper sulfate and 50 ppm BW/day of chrysin). Feed intake (FI) in the Cu + Chrysin group significantly increased in comparison with that of the Cu group (P < 0.01). Cu excess significantly increased malondialdehyde, indicating oxidative stress. Chrysin and FM administration significantly decreased malondialdehyde levels and increased the superoxide dismutase and catalase activities in the liver and kidney tissues (P < 0.001). Serum TNF-α levels were significantly lower in the Cu + FM and Cu + Chrysin groups in comparison to the Cu group (P < 0.001). It was seen that FM and chrysin treatments alleviated degeneration, necrosis, and apoptosis in the liver and kidney tissues of the Cu-treated rats. Chrysin appeared to ameliorate the adverse effects on FI and liver and kidney tissues by scavenging where the free radicals are located and increasing the activity of antioxidants.

Nurse Supervisors And Certified Nursing Assistants: Leadership Characteristics And Job Satisfaction, Jennifer Patterson

Walden Dissertations and Doctoral Studies

Significant costs are associated with the turnover rate of certified nursing assistants (CNAs) in skilled nursing facilities (SNFs), and turnover impacts the quality of care for residents of the SNFs through disruption of care. The purpose of this quantitative cross-sectional study was to identify the leadership characteristics of supervisors most associated with the job satisfaction (JS) of CNAs in SNFs. Herzberg's dual factor theory was used as the theoretical framework to explain the relationship between the leadership characteristics and the associated JS. The research question was used to examine the independent variables of trust, teamwork, supportive supervision, leader-follower relationships, and …

Neurochemistry, Physiology, And Behavior In A Model Of Gulf War Illness, Victoria A. Macht

Theses and Dissertations

Upon returning from the first Gulf War, soldiers cited a plethora of unexplained physical and cognitive deficits which have since been termed Gulf War Illness (GWI). Presentation of GWI is positively correlated with pyridostigmine bromide (PB) use, which was prophylactically administered to soldiers in response to threats of chemical warfare. To test the overarching hypothesis that PB interacted with stress of deployment to alter neural, endocrine, and immune systems, the following studies used a 2×2 rodent model with 14 days of drug treatment (vehicle; PB) and 10 days of repeated restraint stress (stressed) or non-stressed-control conditions. Results indicate that PB …

The Effects Of Exercise Training On Cardiovascular-Related Circulating Micrornas, Jacob Luther Barber

Theses and Dissertations

PURPOSE: MicroRNAs (miRNAs) are small regulatory RNAs that post transcriptionally modify mRNAs and control gene expression. Circulating miRNAs are significantly altered following a single session of exercise, however the effects of exercise training on the circulating miRNA profile is unclear. Therefore, the purpose of the present study was to determine the effects of endurance exercise training on the abundance of targeted circulating miRNAs and the association of changes in miRNA levels with concomitant changes in cardiometabolic traits, in a subsample of adults from the HERITAGE Family Study.

METHODS: This exploratory analysis examined 20 previously sedentary adults from the HERITAGE Family …

Clinical Chronobiology: A Timely Consideration In Critical Care Medicine, Helen Mckenna, Der Horst Gtj Van, Irwin Reiss, Daniel Martin

Peninsula Medical School

No abstract provided.

Debriefing With Reflection: Best Practice For Learning In Simulation In Pre-Licensure Nursing Education, Mary Mcdermott

Seton Hall University DNP Final Projects

Purpose: The purpose of this project was intended to transform the outdated method of conducting debrief after simulation by implementing a good judgment model and integrating the concept of “advocacy-inquiry.” This implementation was expected to reduce demoralizing and anxiety producing debrief experiences and improve student reflection and learning in order for students to more deliberately link theory with practice.

Significance: The debrief is often recognized as the component of simulation in which the most effective learning occurs. It is the time when students are provided opportunity to reflect on thoughts, actions and behaviors. Unfortunately, many nursing students often experience undue …

Rgb Image-Based Pupillary Diameter Tracking With Deep Convolutional Neural Networks, Chatchai Wangwiwattana

Computer Science and Engineering Theses and Dissertations

Pupillary diameter monitoring has proven successful at objectively measuring cognitive load. This work presents three robust RGB video based pupillary diameter trackers and compares them for measuring cognitive load using commodity cameras. We investigate the use of modified starburst algorithm from previous work and propose two algorithms: 2-Level Snakuscules and a convolutional neural network which we call PupilNet. Our results show PupilNet outperforms other algorithms in measuring pupil dilation, is robust to various lighting conditions, and robust to different eye colors. In addition, this work explores various deep learning architecture for extracting the pupillary response as well as understand the …

Paleo Journey: An Interactive Paleolithic Cave Art Experience. Using The User Experience (Ux) Design Process To Develop An Interactive And Immersive Paleolithic Cave Art Exhibit Suitable For Children Between Five (5) And Seven (7) Years Old., James J. Parrillo

Theses

Most European caves containing Paleolithic cave art paintings (dating from approximately 10,000 – 50,000 years BP) are no longer accessible to the general public, and their visitor centers often require lengthy travel for tourists. In addition, the interactivity associated with these exhibits largely focus upon computer screens, and not a tactile interface. This Thesis project seeks to create a prototype of a tactile interface on a mock cave surface using projection mapping and motion tracking.

In developing this exhibit, the user experience (UX) design process was used as a methodology for defining, researching and co-designing for a particular user segment. …

An Exploration Of Job Satisfaction Levels, Pathways Into Education, And Recruiting Behaviors Of Teachers In Indiana, Tricia Johnson

All-Inclusive List of Electronic Theses and Dissertations

Teacher retention and recruitment has been studied from many different perspectives, but there is limited research on the issue from the perspectives of current teachers. The purpose of this quantitative study was to gather data to fill a gap in the research concerning teacher recruiting behaviors by asking teachers if they were likely to encourage different categories of people (friend or relative, community member, current student, other students, recent high school graduate, and their own child) to enter the field of education as a profession. Analysis of the data from 2,083 current Indiana teachers found multiple statistically significant differences in …

Metabolic Regulation Of Myocardial Adaptation To Exercise., Andrew Alan Gibb

Electronic Theses and Dissertations

While the benefits of exercise affect several organs, a significant adaptive response occurs within the heart. Exercise promotes cardiac growth, increases angiogenesis, and enhances cardiac function and these adaptations are associated with a cardioprotective phenotype. Additionally, extensive evidence shows that exercise dynamically regulates myocardial metabolism. This can be attributed to both changes in hormonal stimulation, increases in bioenergetic demand, and the bioavailability of circulating substrates. However, it is unclear whether these changes in metabolism contribute to physiologic cardiac growth. We reason that exercise-induced changes in metabolism are required to balance the catabolic and anabolic reactions needed for growth. Specifically, we …

Effects Of Natural Nutritional Beverages On Anaerobic Exercise Performance, Clare Margaret Zamzow

Boise State University Theses and Dissertations

Introduction: Dietary nitrate (NO₃-) can serve as a substrate for the important signaling molecule nitric oxide (NO). Recent studies suggest that NO₃- beet juice could be beneficial during anaerobic (i.e. short duration, high power) exercise, though this area has received much less attention than beet juice’s effects during aerobic exercise. Purpose: The purpose of this study was to determine if acute dietary NO₃- supplementation, in the form of beet juice, could improve measures of anaerobic power in trained, healthy men during a primarily anaerobic bout of exercise. A secondary purpose was to investigate if …

Determination Of The Effects Of Different Maillard Reaction Products On The Taxonomic Composition Of The Gut Microbiota, Nesreen Hamdan Aljahdali

Graduate Theses and Dissertations

The Maillard Reaction (MR) is a non-enzymatic chemical reaction which results in linkage between the amino group of amino acids and the carbonyl group of reduced sugars. This reaction generates Maillard reaction products (MRPs) which are not present naturally in foods, and are responsible for a range of colors, odors, flavors, and other sensory properties. Conflicting reports of MRPs impacts on human health are probably due to the fact that bioconversion of these digestible molecules by the gut microbiota has been marginally taken into account. This study aimed to determine the effects of different MRPs on rodent’s gut microbiota through16S …

Piglet Gut Microbiota Responses To Exposure To Outdoor Simulated Environment And Formula Feeding, Nguyen Vo

Graduate Theses and Dissertations

Several lines of evidence suggest that early-life gut microbiota composition is a crucial determinant of the susceptibility to diseases later in life. Understanding the evolution of early-life gut microbiota and critical factors that can modify this microbial community will espouse the prevention or reversion of health risk originating from dysbiosis of the gut microbiota in the early stage. In this research, we hypothesized that alterations in the environment (simulation of rural conditions by soil exposure) and feeding mode (breastmilk versus formula milk) will have significant impacts on the establishment of the gut microbiota in early life. At first, in literature …

Faculty Perceptions Of Open Educational Resources Quality By Peer Review, Olga Maria Belikov

Theses and Dissertations

In this paper, 936 faculty free response reviews of open textbooks from the Open Textbook Library were analyzed for content and themes. The reviews were completed by faculty members at institutions in the United States and Canada. The textbooks were evaluated regarding their comprehensiveness, content accuracy, relevance longevity, clarity, consistency, modularity, organization structure flow, interface, grammatical errors, and cultural relevance. The results of the reviews found that the across 9360 comments regarding the quality of open textbooks, of these comments 97.3% reflected adequate or exceptional reviews of the textbooks. Faculty often compared the texts to traditional textbooks and in all …

The Body Mass Index Of San Francisco Cold Water Swimmers - Comparisons To U.S. National And Local Populations, And Pool Swimmers, Brendan T. Crow, Ellicott C. Matthay, Stephen P. Schatz, Mark D. Debeliso, Thomas J. Nuckton

International Journal of Exercise Science

International Journal of Exercise Science 10(8): 1250-1262, 2017. To determine if cold-water swimmers have substantial differences in BMI, which might have a protective effect against heat loss during swims in cold water without wetsuits, and to determine if obesity is more or less prevalent in cold-water swimmers, we compared the body mass index (BMI) values of 103 recreational open-water swimmers (mean age 54.3 ±10.8 years) to data from various population groups. Swimmers swam consistently throughout the winter months, in the San Francisco Bay (water temperature range: 9.6° C [49.3 ° F] to 12.6° C [54.7 ° F]), without wetsuits. After …

Toward Improving Metalloenzyme Inhibitor Design: A Thermodynamic Study Of Small Molecule Interactions With Copper(Ii), Cobalt(Ii) And Manganese(Ii), Fatimah Aldakheel

College of Science and Health Theses and Dissertations

This work aimed at understanding the interactions of 1) three physiologically relevant transition metal ions copper(II), cobalt(II) and manganese(II) with five tri- or tetra-dentate metal chelators (ligand or L) and 2) the resulting ML complexes with two known metalloenzyme inhibitors, 8-hydroxyquinoline (8-HQ) and acetohydroxamic acid (AHA). The ultimate goal of the work was to identify ligands that can form enzyme active site M²⁺ structural mimetics capable of interacting with metalloenzyme active site inhibitors. The ligands studied were N-(2-(1-methylimidazolyl)methyl)iminodiacetic acid (DA2Im), nitrilotriacetic acid (NTA), tris(2-aminoethyl)amine (TREN), tris(2-pyridylmethyl)amine (TPA), and bis(2-picolyl)amine (BPA) and they were chosen to mimic the coordination environment …

How Socioeconomic Disadvantages Get Under The Skin And Into The Brain To Influence Health Development Across The Lifespan, Pilyoung Kim, Gary W. Evans, Edith Chen, Gregory Miller, Teresa Seeman

Psychology: Faculty Scholarship

Socioeconomic disadvantage (SED) has adverse impacts on physical (Adler and Rehkopf 2008; Blair and Raver 2012; Braverman and Egerter 2008; Cohen et al. 2010; Poulton et al. 2002) and psychological (Adler and Rehkopf 2008; Bradley and Corwyn 2002; Grant et al. 2003) health development. SED is similar to low socioeconomic status (SES) which is based on occupation, income, and education or a composite of more than one of these indicators (McLoyd 1998). However, we conceptualize SED more broadly than socioeconomic status to also include subjective perception of social position and contextual indicators of disadvantage, such as neighborhood deprivation. One of …

Mitochondrial Reactive Oxygen Species In Lipotoxic Hearts Induces Post-Translational Modifications Of Akap121, Drp1 And Opa1 That Promote Mitochondrial Fission, Kensuke Tsushima, Heiko Bugger, Adam R. Wende, Jamie Soto, Gregory A. Jenson, Austin R. Tor, Rose Mcglauflin, Helena C. Kenny, Yuan Zhang, Rhonda Souvenir, Xiao X. Hu, Crystal L. Sloan, Renata O. Pereira, Vitor A. Lira, Kenneth W. Spitzer, Terry L. Sharp, Kooresh I. Shoghi, Genevieve C. Sparagna, Eva A. Rog-Zielinska, Peter Kohl, Oleh Khalimonchuk, Jean E. Schaffer, E. Dale Abel

Department of Biochemistry: Faculty Publications

Rationale: Cardiac lipotoxicity, characterized by increased uptake, oxidation and accumulation of lipid intermediates, contributes to cardiac dysfunction in obesity and diabetes. However, mechanisms linking lipid overload and mitochondrial dysfunction are incompletely understood.

Objective: To elucidate the mechanisms for mitochondrial adaptations to lipid overload in postnatal hearts in vivo.

Methods and Results: Using a transgenic mouse model of cardiac lipotoxicity overexpressing long-chain acyl-CoA synthetase 1 in cardiomyocytes, we show that modestly increased myocardial fatty acid uptake leads to mitochondrial structural remodeling with significant reduction in minimum diameter. This is associated with increased palmitoyl-carnitine oxidation and increased reactive oxygen species (ROS) generation …

Ligand Modulation Of Sidechain Dynamics In A Wild-Type Human Gpcr, Lindsay D. Clark, Igor Dikiy, Karen Chapman, Karin Ej Rodstrom, James Aramini, Michael V. Levine, George Khelashvili, Soren Gf Rasmussen, Kevin H. Gardner, Daniel M. Rosenbaum

Publications and Research

GPCRs regulate all aspects of human physiology, and biophysical studies have deepened our understanding of GPCR conformational regulation by different ligands. Yet there is no experimental evidence for how sidechain dynamics control allosteric transitions between GPCR conformations. To address this deficit, we generated samples of a wild-type GPCR (A2AR) that are deuterated apart from 1H/13C NMR probes at isoleucine d1 methyl groups, which facilitated 1H/13C methyl TROSY NMR measurements with opposing ligands. Our data indicate that low [Na+] is required to allow large agonist-induced structural changes in A2AR, and that patterns of sidechain dynamics substantially differ between agonist (NECA) and …

Mid-Atlantic Ethics Committee Newsletter, Fall 2017

Mid-Atlantic Ethics Committee Newsletter

No abstract provided.