Digital Commons Network^™

Does Lavender Aromatherapy Or Tea Improve Quality Of Sleep In Women?, Meredith A. Mcnelis

PCOM Physician Assistant Studies Student Scholarship

Objective: The objective of this selective EBM review is to determine whether or not “Does Lavender Aromatherapy or Tea Improve Quality of Sleep in Women?”

Study Design: Systematic review of three English language, primary, randomized controlled trials published between 2012 and 2015.

Data Sources: Three randomized controlled trials were obtained using PubMed and NCBI.

Outcomes Measured: The clinical outcome of sleep quality was measured in these studies via the Postpartum Sleep Quality Scale (PSQS), the Pittsburgh Sleep Quality Index and the Chinese Pittsburgh Sleep Quality Index (CPSQI).

Results: Statistical significance was determined for each randomized control trial (RCT) using pvalue …

Catalog Changes Rn Bs, Nursing

Program Revisions/Additions

No abstract provided.

Catalog Cover Sheet Rn To Bs In Nursing, Nursing

Program Revisions/Additions

No abstract provided.

Rn To Bs, Nursing

Program Revisions/Additions

No abstract provided.

Health Administration, Health Promotion

Program Revisions/Additions

No abstract provided.

Workplace Standing Desks And Arterial Stiffness, Ian Greenlund

Dissertations, Master's Theses and Master's Reports

Many jobs in today’s society require sitting at a desk with little physical activity. Individuals who engage in ten hours of sedentary behavior per day double their CVD risk. Standing desks are thought to decrease sedentary time and improve cardiovascular health. Acute use of standing desks is shown to lower PWV. However, chronic effects remain unknown. Forty eight participants qualified as seated (19 females, 5 males: age 41 ± 2 years, BMI 25 ± 1 kg/m²) or standing (21 females, 3 males: age 45 ± 2 years, BMI 25 ± 1 kg/m²) groups based on habitual …

Milk Exosomes Are Bioavailable And Distinct Microrna Cargos Have Unique Tissue Distribution Patterns, Sonia Manca, Bijaya Upadhyaya, Ezra Mutai, Amy T. Desaulniers, Rebecca A. Cederberg, Brett R. White, Janos Zempleni

Department of Nutrition and Health Sciences: Faculty Publications

Exosomes participate in cell-to-cell communication, facilitated by the transfer of RNAs, proteins and lipids from donor to recipient cells. Exosomes and their RNA cargos do not exclusively originate from endogenous synthesis but may also be obtained from dietary sources such as the inter-species transfer of exosomes and RNAs in bovine milk to humans. Here, we assessed the bioavailability and distribution of exosomes and their microRNA cargos from bovine, porcine and murine milk within and across species boundaries. Milk exosomes labeled with fluorophores or fluorescent fusion proteins accumulated in liver, spleen and brain following suckling, oral gavage and intravenous administration in …

Physiological Responses In Reindeer To The Application Of A Conducted Electrical Weapon, Camilla L. Lieske, Kimberlee B. Beckmen, Larry L. Lewis

Human–Wildlife Interactions

Conducted Electrical Weapons (CEWs) have potential as effective alternatives to chemical restraint for short-term non-routine capture and handling as well as aversion hazing of wildlife. To assess immediate and delayed physiologic effects of exposure to a CEW, we assigned 15 captive reindeer (Rangifer tarandus tarandus) to one of three treatment groups: immobilized with carfentanil and xylazine (CX), 10 second exposure to a CEW, or exposure to the CEW while immobilized with CX (CEW+CX). Blood samples were collected pre-treatment, immediately post-intervention, 10 min, 20 min, 4 hours, and 24 hours post-intervention. Physiologic effects were evaluated by analysis of blood, …

Gastrointestinal Microbiota Modulate Antinociceptive Tolerance Development In Mice With Chronic Morphine Exposure, Ryan A. Mischel

Theses and Dissertations

In October 2017, the United States government declared a state of public health emergency in response to the burgeoning prescription opioid epidemic. Opioid analgesics are the gold standard of therapy for moderate to severe pain, but their clinical utility is greatly limited by analgesic tolerance – a primary driver of diminished pain control and opioid dose escalations. Integral in this process are primary afferent sensory neurons in dorsal root ganglia (DRG), the first-order components of nociceptive sensation. With surmounting evidence that morphine and other narcotics can alter gut microbial composition and promote bacterial translocation to other tissues, a question arises …

Touching The Unreal: The Definition, Narrative Strategies, And Aesthetics Of 3d Cartoon Narratives., Nathan Snow

Electronic Theses and Dissertations

"Touching the Unreal" follows the structure set out by Scott McCloud in Understanding Comics to argue that understanding cartoons is serious business and requires that we define the art form, outline its basic tenets, and theorize how the mind understands it. The dissertation argues for a new definition of 3D computer generated cartoons, beginning with the most basic definition applicable to all forms of animation and taking into account new technological developments before arriving at the 3D cartoon narratives of today. The dissertation outlines the basic facets of 3D cartoon narratives in terms of narrative and aesthetics, arguing that, in …

Regulation Of Extra-Pituitary Prolactin In Monocytes And Macrophages, Richard Barrett

Electronic Theses and Dissertations

Recently it has been shown that leukocytes are capable of producing prolactin (PRL). Evidence of extra-pituitary PRL (ePRL) production is so far been limited to primates and is not shared across other mammal species such as mice and rats. While ePRL is characterized as an identical protein to traditional pituitary PRL, it is controlled under an alternative promoter and is thus regulated differently from pituitary PRL. Little is known about what regulates ePRL or its direct role in human physiology, but given that PRL has well over 300 described functions, it is likely that the autocrine and paracrine effects of …

Characterization Of Neural Cells Derived From Reelin-Deficient Schizophrenic Patient Ips Cells, Nicole Roberts

Electronic Theses and Dissertations

Reelin is a large, extracellular glycoprotein that binds to several membrane receptors on neural stem cells (HNSCs), neural progenitor cells (NPCs), and neuroblasts of mammals to direct their migration. Previously, our lab established the presence of Reelin increased migration of wild-type fetal-derived HNSC's, both in vitro and in vivo. In addition, we demonstrated that Reelin protein treatment also increases the formation of radial glia via Notch-1 signaling, in vitro. Radial glia are precursors to NPCs, as well as a scaffold for neuroblast migration during cortical lamination. Reelin has long been associated with Schizophrenia (SZ). Because post-mortem brains are limited to …

Biom 3110: Medical Physiology (Syllabus), Bradford D. Pendley

Biomedical Engineering Syllabi Archive

Course Description: Basic principles of human physiology and how these are applied in medicine and biomedical engineering problem and devices; physiological principles using appropriate mathematical and engineering models to construct an understanding of how the body works as an integrated system.

Modeling Of Realistic Heart Electrical Excitation Based On Dti Scans And Modified Reaction Diffusion Equation, Ihab Elaff

Turkish Journal of Electrical Engineering and Computer Sciences

A new method is proposed for modeling realistic heart activation using diffusion tensor imaging (DTI) scans based on biological properties of its tissues in addition to the working methodology of the DTI scanner. Modeling of the excitation propagation inside the heart is initiated by applying activation at only one pacing site at the root of the conduction network. The excitation propagation has been accomplished based on a proposed conduction system that is extracted from DTI heart scans and a modified version of monodomain reaction diffusion equation (RDE) that considers the heart inhomogeneous--anisotropic material. The Aliev--Panfilov method was used to model …

Gendered Language And The Construction Of Jewish Identity In 2 Maccabees, Joshua Ezra Burns

Theology Faculty Research and Publications

No abstract provided.

Inhibition Of Blood Coagulation Factor Xii: Evaluation Of Flavonoids As A Drug Candidate, Betsy Crosswhite

Honors Theses

This study investigated natural product inhibitors of blood coagulation Factor XII (FXII). FXII initiates the Kallikrein Kinin-System (KKS) within the intrinsic coagulation pathway. Increased expression of this system leads to proinflammatory and procoagulant activities. Inflammation occurs through downstream activation in the KKS. Following the activation of FXII-dependent pathway, bradykinin (BK) binds to the BK receptor 2 (B2) and produces inflammatory signaling. Abnormally increased BK can result in life threatening Hereditary Angioedema (HAE), characterized by severe reoccurring swelling. FXII is critical for pathogenic thrombosis, but is dispensable for hemostasis. This unique property of FXII makes it an attractive drug target. We …

Purification Protocol Development And Analysis Of Binding Properties Of Calmodulin Collagen-Like Protein, Patrick P. Boddie

Honors Theses

Calmodulin is an intensely studied, intracellular, calcium-binding protein that is involved in diverse physiological processes. When bound to calcium, calmodulin undergoes a conformational change that allows it to bind specific target peptides with high affinity, one being the calmodulin binding region of myosin light chain kinase, herein called M13. This high affinity, calcium dependent association has made it a desirable choice for use in a biomaterial for drug delivery for non-steroidal anti- inflammatory drugs (NSAIDs). Two artificial genes have been designed by our lab for use in the proposed biomaterial: calmodulin collagen-like protein (CCLP), a construct composed of two calmodulin …

Connecting The Mind And Body In Ancient Greek Medicine, Taylor Ferris

Honors Theses

I investigated Greek medicine and healing shrines in antiquity and focused on the issue of the mind-body connection and how this phenomenon was understood in antiquity. I researched the Athenian plague of 430-425 B.C., sleep and dreams, particularly in the Rites of Incubation, and Hippocratic medicine as well as religious medicine in order to understand more deeply the origins of Greek medicine and how the healing phenomena were practiced and understood. I have come to a greater understanding of this connection between the mind and the body and have come to redefine the placebo effect and argue that the mind …

Centrifugal Microfluidics For Label-Free Isolation Of Leukocytes Subpopulations From Whole Blood, Yuxi Sun

All ETDs from UAB

Leukocytes carry critical information regarding the immediate immune and inflammation status of the patients. Analysis of leukocytes requires isolation from blood since the leukocytes only consist <1% of all blood cells. Commonly used isolation processes exploit physical or biochemical differences between different cell types to enable separations. Current isolation methods inevitably subject cells to physical or biochemical stress that can activate leukocytes and change their natural state. Thus, information contained within isolated leukocytes is a combination of the natural state of the cell and an artifact of the isolation process. Microfluidics which takes advantage of scaling effects within microscale structures can ensure rapid and gentle alternatives to conventional isolation methods and is ideal for sorting, and analysis of cells and particles. The precise control of flow/particles and scaling effects of microfluidics have been applied for blood cells sorting and isolation. However, the limited processing capability and throughput as well as complex fabrication and operations have hampered widespread adoption of these approaches for replacement of conventional methods. My goal was to develop a simple yet powerful microfluidic tool that enables rapid separation of leukocytes while ensuring sufficient throughput, and minimizing isolation process induced activation without the need any sample pre-processing. This project is divided into two specific aims: i) to miniaturize the conventional density gradient centrifugation using centrifugal microfluidics for PBMC isolation and evaluate separation efficiency and activation status of isolated cells in comparison to conventional techniques; ii) develop new approach for PBMC sorting using microfluidic phase partitioning to enable separation of cells based on differences in cell surface energy. For specific aim 1, PBMCs were isolated based on differences in densities using microfluidic density gradient centrifugation. We show that PBMCs can be isolated from 100µl whole blood within 5 minutes. Evaluation of leukocyte activation via profiling of expression of surface integrins and chemokine receptors shows that our microfluidic approach significantly reduced PBMC activation in comparison to conventional isolation approaches. In specific aim 2, we sought to isolate cells based on differenced in surface energy using two-phase partitioning of dextran (DEX) and polyethylene glycol (PEG). Proof of concept demonstrations was accomplished using with polystyrene and silicon dioxide microbeads which represent a mixture of white blood cells and red blood cells. The DEX and PEG mixtures were introduced into a circular channel and phase separated under centrifugal force into unique DEX and PEG phases. The bead mixture was isolated via differences in their affinity to the two phases.

A Review Of Heat Stress Policies In The Context Of Climate Change And Its Impacts On Outdoor Workers: Evidence From Zimbabwe, Bigboy Ngwenya, Jacques Oosthuizen, Martyn Cross, Kwasi Frimpong, Cynthia N. Chaibva

Research outputs 2014 to 2021

Record-breaking summer heat events are increasing in frequency in Zimbabwe and 2016 was a particularly hot year with the country experiencing its worst heat wave event in decades. Currently, Zimbabwe has no coordinated public health response to deal with heat wave events and no specific data on heat-related morbidity and mortality. The country has no legislation for protecting workers against environmental heat exposure, particularly those most vulnerable who are employed in the informal sector. These workers are also at risk due to their outdoor work environments. The article outlines the state of climate and heat stresses in Zimbabwe, as benchmarked …

Formulation Of Nanoparticle Systems For Drug Delivery Application In Biomedical Sciences, Victor Alfredo Rodriguez

Open Access Theses & Dissertations

Antibiotic-resistant strains of bacteria may result in serious infections which are difficult to treat. In addition, the poor antibiotic pipeline has also contributed to the crisis. Recently, the complex of furosemide and silver (Ag-FSE) has been reported as a potential antibacterial agent. However, its poor aqueous solubility is limiting its activity as an effective antibacterial agent. The purpose of this study was to encapsulate Ag-FSE into chitosan nanoparticles (CSNPs) and evaluate antibacterial efficacy. Ag-FSE CSNPs were prepared using ionic gelation technique. The particle size, polydispersity index and zeta potential of Ag-FSE CSNPs were determined using dynamic light scattering (DLS) technique. …

A Continued Musical And Personal Dialogue With The Waves Of Epilepsy., Alan Douglas Miles

Other Faculty of Arts, Humanities and Business Theses

A Continued Musical and Personal Dialogue with the Waves of Epilepsy. In the early hours of the morning several years ago I awoke with paramedics leaning over me. In a state of confusion, my first conscious decision was to enter my music production studio while they attempted to lead me to the ambulance. Music was important to me even in a disorientated post-ictal state (an altered state of consciousness following a seizure). Two weeks later I awoke with paramedics standing over me again. I had started to experience multiple seizures. During the previous weeks, I also experienced numerous incidents of …

“We’Re Being Left To Blight”: Green Urban Development And Racialized Space In Kansas City, Chhaya Kolavalli

Theses and Dissertations--Anthropology

In this dissertation, I explore ‘green’ urban development and urban agriculture projects from the perspective of residents of an African American majority neighborhood in Kansas City—who reside in an area referred to as a ‘blighted food desert’ by local policy makers. In Kansas City, extensive city government support exists for urban agricultural projects, which are touted not just as a solution to poverty associated issues such food insecurity and obesity, but also as a remedy for ‘blight,’ violence and crime, and vacant urban land. Specific narratives of Kansas City’s past are used to prop up and legitimate these future visions …

Reduced Graphene Oxide-Modified Screen-Printed Carbon Electrode For Determination Of Homocysteine Using Catechol, Suchapa Naranaruemol

Chulalongkorn University Theses and Dissertations (Chula ETD)

Homocysteine (Hcy), also known as 2-amino-4-mercaptobutyric acid, is a biomarker that is directly associated with an increased risk of cardiovascular diseases (CVDs). In this work, catechol (CA), which is redox active, had been used as an electron transfer mediator to facilitate the oxidation of Hcy. Typically, CA was first electrochemically immobilized onto the surface of screen-printed carbon electrode; however, the obtained CA-functionalized electrode did not show the electrocatalytic activity towards the detection of Hcy. Therefore, the deter– mination of Hcy was investigated in the solution containing CA using differential pulse voltammetry (DPV) at the reduced graphene oxide-modified screen-printed carbon electrode …

Pm10 And Pm2.5 Concentrations In Bangkok Over 10 Years And Implications For Air Quality, Tin Thongthammachart

Chulalongkorn University Theses and Dissertations (Chula ETD)

Atmospheric particulate matter particles with a diameter less than 10 micron (PM10) and less than 2.5 micron (PM2.5) have been adverse human health effect. Ambient air pollution data in Central Business District (CBD) of Bangkok monitored by Pollution Control Department and Bangkok Metropolitan Administration were collected over ten years in Bangkok from 2008 to 2017. Trend of the particulate matter concentrations data were investigated over ten year for implications of activities related to air pollution. Daily average air pollution data between year 2015 and year 2017 were used as the dependent variables to develop mathematic models with multiple linear regression …

Effects Of The Na-Cl Co-Transporter (Ncc) In Western Diet Induced Metabolic And Cardiac Dysfunction, Zachary S. Cutter

Theses and Dissertations

Interleukin-18 (IL-18) is a pro-inflammatory cytokine known to be involved in maintaining metabolic homeostasis; however, also capable of inducing cardiac dysfunction. Additionally, IL-18, has been shown to bind to a novel receptor, the Na-Cl Co-transporter (NCC). We hypothesized that NCC mediates IL-18 metabolic and cardiac signaling in mice. Using male C57BL/6J mice, we compared the metabolic and cardiac function changes after at least 8 weeks of high-saturated fat high sugar diet (Western Diet) in NCC knockout (NCCKO), IL-18 knockout (IL-18KO), and wild-type mice. We show that NCCKO mice have significantly increased body weight gain from baseline, no difference in fasting …

Faculty Publications 2017, Lsu Health Sciences Center New Orleans

Historical Faculty Publications

This Faculty bibliography contains 947 publications.

A Study Of Hormonal Effects In Cervical Smear Samples Using Raman Spectroscopy, D. Traynor, P. Kearney, I. Ramos, C. M. Martin, J. J. O'Leary, Fiona Lyng

Articles

Raman spectroscopy is a powerful tool that has the potential to be used as a screening method for cervical cancer. It is a label-free, low-cost method providing a biochemical fingerprint of a given sample. The objective of this study was to address patient-to-patient variability contributed by hormonal effects due to the menstrual cycle, the use of hormone-based contraceptives (HC) and the onset of menopause, and to determine if these changes would affect the ability to successfully identify dyskaryotic cells. Raman spectra were recorded from unstained ThinPrep cervical samples (45 cytology negative and 15 high-grade dyskaryosis (high-grade squamous intraepithelial lesion, HSIL) …

Quantifying Excess Deaths Related To Heatwaves Under Climate Change Scenarios: A Multicountry Time Series Modelling Study, Yuming Guo, Antonio Gasparrini, Shanshan Li, Francesco Sera, Ana Maria Vicedo-Cabrera, Micheline De Sousa Zanotti Stagliorio Coêlho, Paulo Hilário Nascimento Nascimento Saldiva, Éric Lavigne, Benjawan Tawatsupa, Kornwipa Punnasiri, Ala Overcenco, Patricia Matus Correa, Nicolas Valdes Ortega, Haidong Kan, Samuel Osorio, Jouni J.K. Jaakkola, Niilo R.I. Ryti, Patrick J. Goodman, Ariana Zeka, Paola Michelozzi, Matteo Scortichini, Masahiro Hashizume, Honda, Yasushi Honda, Yasushi, Xerxes T. Seposo, Ho Young Kim, Aurelio Tobías, Carmen Iñiguez Fernández, Bertil Forsberg, Daniel Oudin Åström, Guo, Yue Leon Guo, Yue Leon, Bing Yu Chen, Antonella Zanobetti, Joel D. Schwartz, Tranngoc Ngoc Dang, Dung Do Van, Michelle L. Bell, Ben G. Armstrong, Ebi, Kristie L. Ebi, Kristie L., Shilu Tong

Articles

Background: Heatwaves are a critical public health problem. There will be an increase in the frequency and severity of heatwaves under changing climate. However, evidence about the impacts of climate change on heatwave-related mortality at a global scale is limited. Methods and findings: We collected historical daily time series of mean temperature and mortality for all causes or nonexternal causes, in periods ranging from January 1, 1984, to December 31, 2015, in 412 communities within 20 countries/regions. We estimated heatwave–mortality associations through a two-stage time series design. Current and future daily mean temperature series were projected under four scenarios of …

Ample Evidence For Fish Sentience And Pain, Lynne U. Sneddon, David C.C. Wolfenden, Matthew C. Leach, Ana M. Valentim, Peter J. Steenbergen, Nabila Bardine, Donald M. Broom, Culum Brown

Animal Sentience

The majority of commentaries are supportive of our position on the scepticism that muddies the waters surrounding fish pain and sentience. There is substantial empirical evidence for pain in fish. Animals’ experience of pain cannot be compared to artificial intelligence (AI) because AI can only mimic responses to nociceptive input on the basis of human observations and programming. Accepting that fish are sentient would not be detrimental to the industries reliant on fish. A more proactive discussion between scientists and stakeholders is needed to improve fish welfare for the benefit of all.