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Dynamical Behavior, Extinction And Persistence In A Stochastic Delayed Two-Strain Epidemic Model With A Generalized Crowley-Martin Incidence Rate, Amina Allali, Dounia Bentaleb, Saida Amine

Mathematical Modelling and Numerical Simulation with Applications

This paper develops and analyzes a novel delayed stochastic SIR epidemic model with two interacting strains and general incidence functions. By establishing the existence and uniqueness of a positive global solution, the well-posedness of the model under stochastic perturbations is ensured. Extinction occurs when the stochastic reproduction number falls below unity, as demonstrated through Itô calculus and martingale convergence theorems, while persistence is guaranteed under the Crowley–Martin incidence when it exceeds one. Numerical experiments based on the Positive Preserving Truncated Euler–Maruyama (PPTEM) scheme confirm the analytical predictions and highlight the influence of time delay and noise intensity on the long-term …

Tumor–Immune Dynamics With Memory And Time Delay: A Fractional-Order Model With Ctla-4 Regulation, Mutaz Mohammad, Mohyeedden Sweidan, Alexander Trounev, Fathalla Rihan

Mathematical Modelling and Numerical Simulation with Applications

This study develops a fractional-order tumor-immune interaction model incorporating Caputo memory effects, delayed immune activation, and CTLA-4 checkpoint regulation. The model describes the coupled dynamics of tumor cells, CD4$^{+}$ T cells, IFN-$\gamma$, and CTLA-4, and extends classical integer-order tumor-immune models by accounting for hereditary immune responses and biologically motivated latency effects. Theoretical properties, including positivity, boundedness, equilibrium structure, and fractional-order stability, are examined to establish the biological and mathematical consistency of the model. The delayed fractional system is then investigated computationally by comparing several numerical methods, including finite difference discretization, Daubechies wavelet collocation, Euler wavelet collocation, and a predictor-corrector scheme. …

Protecting Graduate Students From Burnout With Self-Compassion And Authenticity, Michael S. Leeman, Joshua J. Castleberry, Anna A. Ellenson, Morgan Wallbrown

Journal of Social, Behavioral, and Health Sciences

This study investigated whether practicing self-compassion and embracing one's authentic self could protect graduate students from burnout. Researchers also empirically examined the mediating effect of authenticity in the relationship between self-compassion and burnout. A total of 318 master's degree students in a helping profession completed surveys assessing their levels of self-compassion, authenticity, and burnout. Results found that graduate students with higher levels of self-compassion and authenticity tended to have lower levels of burnout. Additionally, authenticity mediated the relationship between self-compassion and burnout. The findings suggest that practicing self-compassion and embracing one's authentic self may lead to lower levels of burnout …

Crispr/Cas9-Based Genome Editing: Understanding Differences In Dna Repair Pathways, Profiles, And Outcomes, Samuel Effah, Shirley Barrera, Nahia Urturi Ortiz, Will Dampier, Michael Nonnemacher, Brian Wigdahl

Kimmel Cancer Center Faculty Papers

Over a decade of advances in Clustered Regularly Interspersed Short Palindromic Repeats (CRISPR) and CRISPR-associated protein 9 (Cas9)-based technologies have culminated in the first-ever FDA-approved CRISPR/Cas-based therapy. Aside from this approved therapy for sickle cell anemia, several CRISPR/Cas-based therapies are currently under development or testing for a range of chronic diseases, including viral diseases like human immunodeficiency virus type 1 (HIV-1) infection, genetic diseases like familial hypercholesterolemia, and cancer. The success of these therapies hinges on the effective delivery of CRISPR/Cas9 components to target regions, efficient Cas endonuclease editing, repair profiles generated, and their resulting outcomes. Here, we discuss the …

Us Race/Ethnic Disparities In Diabetes Technologies: A Systematic Review And Meta-Analysis Of 950 000 Individuals, Maria L. M. Rego, Maxim Barnett, Maria Helena Siqueira Tavares De Melo, Ana Rivadeneira

Einstein Health Papers

PURPOSE: To provide a descriptive summary and to quantitatively examine racial and ethnic disparities in the use of continuous glucose monitoring (CGM) and continuous subcutaneous insulin infusion (CSII) among people living with diabetes in the United States.

RESEARCH DESIGN AND METHODS: We followed the Cochrane and PRISMA guidelines (PROSPERO: CRD420251124678). Search was conducted on PubMed, Embase, and Cochrane up to August 2025. Observational studies were included if they (1) were conducted in the United States, (2) evaluated the use of CGM/CSII across different races/ethnic groups, and (3) reported odds ratios (ORs) for between-group comparisons. Three-level random-effect meta-analyses examined OR in …

Interval-Valued Neutrosophic Dombi Bonferroni Mean Aggregation Operators In Medical Diagnosis And Sustainable Energy, Maryam Faisal, Muhammad Nadeem, Muhammad Kamran

Neutrosophic Systems with Applications

Medical diagnosis is one of the most difficult fields in which decisions must be made due to the fact that medical information often has characteristics of uncertainty, incompleteness, imprecision and even contradiction. Traditional aggregation and decision-making methods are often not well suited to such complexities, and may result in less reliable diagnostic outcomes. In order to overcome these drawbacks, the authors propose a new approach using a novel representation of Interval-Valued Neutrosophic Sets (IVNSs), the Dombi operational laws, and Bonferroni Mean (BM) aggregation operators. The proposed framework is specifically aimed at coping with uncertainty, indeterminacy and falsity all at once …

Liver Function Tests, Calcium, And Phosphorus Levels In The Graves' Disease Patients, Munaf Faraj Rashid, Haider Abd. Jabbar Alammar, Abbas Mahdi Rahmah

Al-Qadisiyah Medical Journal

Background: Graves' disease is an autoimmune disorder that affects the thyroid gland, a small butterfly-shaped organ located in the anterior of the neck. In this case, the immune system mistakenly attacks the thyroid, leading to the overproduction of thyroid hormones. The most common result of Graves' disease is an overactive thyroid gland, which produces an excess of thyroid hormones (thyroxine or T4 and triiodothyronine or T3). This can lead to symptoms such as weight loss, rapid heartbeat, anxiety, irritability, heat intolerance, and increased sweating. The thyroid gland may become enlarged, causing a noticeable swelling in the front of the neck. …

Psoriasis Effects On Psychological And Daily Activities In Patients Attending To Outpatient Clinics In Aldiwaniyah Teaching Hospital, Saja Abbas Musa, Hassan Raji Jallab, Akeel Hamid Jabur

Al-Qadisiyah Medical Journal

Background: Psoriasis is a chronic immune-related skin disorder affecting 2–3% globally, linked to heart disease, joint issues, metabolic syndrome, and psychological disorders. It also impacts social life, mental health, and work productivity, with added challenges in Middle Eastern patients due to stigma and limited healthcare access. Aim: To assess the psychological and functional impact of psoriasis on patients attending Al-Diwaniyah Teaching Hospital. It focuses on anxiety, depression, social disengagement, and effects on daily activities like work, exercise, sleep, and hygiene. The study also explores the relationship between disease severity and impairment levels. Material and Methods: The study was conducted at …

Correlation Of Norepinephrine With Some Biochemical Parametric In Patients With Type 2 Diabetes Mellitus, Aqeel Abed Nour Hadi, Ferdous A. Jabir, Muhammad Abd-Alwahab

Al-Qadisiyah Medical Journal

Background: Type 2 diabetes is a chronic metabolic disorder characterized by high blood sugar levels (hyperglycemia) resulting from the body's reduced ability to produce or use insulin effectively. Insulin is a hormone that regulates blood sugar levels, and in type 2 diabetes, the body either does not produce enough insulin or becomes resistant to its effects. This causes a buildup of glucose in the bloodstream, which can eventually harm organs and tissues. This study was carried out on patients who attended the Diabetes and Endocrinology Specialist Center of Marjan City for Medical Education in Babil Province; all patients were diagnosed …

Lipase And Tcf7l2 Polymorphism As Indicators Of Pancreatic Dysfunction In Patients With Breast Cancer, Dhay Ihab Al-Jdooa, Ahmed Ghdhban Al-Ziaydi

Al-Qadisiyah Medical Journal

Background: Pancreatic dysfunction is widely acknowledged as a critical issue in individuals with breast cancer. These biomarkers like insulin, lipase, and amylase or polymorphisms such as TCF7L2 can be correlated in assessing breast cancer in conjunction with other medicine relations such as pancreatic health. Objective: The aim of this particular study is to assess the role of breast cancer in pancreatic dysfunction by assessing the aforementioned biomarkers and gene polymorphisms. Methods: Following ethical guidelines, a case-control study was conducted involving female patients diagnosed with breast cancer and other breast cancer-free women. Various combined diagnostic tests, including ROC curve analysis and …

Ophthalmic Complications In Thalassemia Patients Using Iron Chelating Therapy, Haider Aswad Layikh, Zainab Yousif Ismael, Dheya Nema Kadhum

Al-Qadisiyah Medical Journal

Background:\ Thalassemia's are a group of genetic diseases which are considered as the most common single gene disorder which are usually treated with repeated blood transfusions that may lead to iron accumulations in the body with multi organ complications. Objectives:\ The objectives of this study was to evaluate the most commonly observed ocular signs and complications of beta-thalassemia major, as well as to determine whether there are any significant ocular side effects of the iron chelators taken by many of these patients for the treatment of their condition. Materials & Methods:\ this cross sectional study evaluated the …

Detection Of Uropathogenic Multidrug-Resistant Escherichia Coli And Klebsiella Pneumoniae Isolates In Some Immunocompromised Patients., Alaa Abd Atia, Manal Mohammed Kadhim

Al-Qadisiyah Medical Journal

Background: Multidrug-resistant E. coli and K. pneumoniae isolates are the most common causes of acquired urinary tract infections (UTIs). Objective: Conclude the prevalence of multidrug-resistant E. coli and K. pneumoniae isolates in urine samples from immunocompromised patients with UTIs. Methods: A total of 543 urine samples were collected from patients with supposed UTIs. MacConkey, chromogenic agar, and blood culture were used to cultivate the samples. Disk diffusion on Mueller-Hinton agar was used to select cultures that were positive for testing for antibiotic susceptibility. Excel and SPSS software were used to gather and analyze the data. Results: Of …

Religious Trauma And Social Identity Af Santri: A Qualitative Study In A Pesantren Environment, Himmatuz Zakiyah

Journal Of Middle East and Islamic Studies

This qualitative study examines religious trauma experiences among Santri in a modern Indonesian pesantren, focusing on how teachers weaponize Qur'anic verses and hadiths as tools of symbolic violence. Data were collected through semi structured interviews with five Santri and alumni from Bumi Shalawat Islamic Boarding School, a pseudonym. Findings reveal that selective quotation, decontextualization, and threat based hermeneutics, which I term scriptural violence, are systematically used to enforce conformity, suppress doubt, and induce shame. This scriptural violence operates through three mechanisms. Theological gaslighting denies Santri's interpretive agency. Eschatological blackmail threatens divine punishment. Prophetic proof texting misuses hadiths to legitimize authoritarian …

Re: Conditional Approval Letter For Diggings East 100% Remedial Design Package Submittal (Dated May 29, 2006), Emma Rott

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Institutionalizing Public Consultation In Thai Health Legislation: Lessons From Ria And Pls Practices, Stithorn Thananithichot, Wichuda Satidporn, Chompunoot Tangthavorn

Asia-Pacific Social Science Review

Public consultation is increasingly recognized as a cornerstone of democratic governance, yet its institutionalization in middle-income democracies such as Thailand remains uneven. Although the 2017 Constitution and the 2019 Act on Legislative Drafting and Legal Evaluation mandate participatory processes through Regulatory Impact Assessment (RIA) and Post-Legislative Scrutiny (PLS), implementation has often remained procedural rather than substantive. This study examines how consultation practices operate within Thailand’s public health legislation, a policy domain characterized by significant distributive and ethical implications. Using a qualitative comparative case study design, the research analyzes three legislative processes: the National Health Security Act B.E. 2545 (2002), the …

The Way Perceived Justice Affects Environmental Policy Support, Cholnapa Anukul, Kanang Kantamaturapoj

Asia-Pacific Social Science Review

Perceptions of justice have been widely discussed as an important lens through which individuals interpret social experiences and evaluate public policies. This exploratory qualitative study examines how perceived justice, particularly Belief in a Just World (BJW), is associated with attitudes toward support for environmental policy among undergraduate students aged 18 years or older recruited from higher education institutions (HEIs) in Bangkok, Thailand. An online screening survey was used to identify students with relatively high and low levels of Personal Belief in a Just World (PBJW) from four HEIs, followed by in-depth interviews with 21 participants. Reflexive thematic analysis was employed …

Melodrama And The Ecological Imagination: K-Dramas And Thai Lakorns As Instruments Of Soft Environmental Diplomacy, Antonio P. Contreras

Asia-Pacific Social Science Review

This paper examines how Asian serialized dramas, particularly Korean television dramas (K-Dramas) and Thai Lakorns, function as cultural texts that shape ecological imagination within the Philippine media environment. Using interpretive visual-textual analysis of Crash Landing on You, My Mister, 2gether: The Series, and Bad Genius: The Series, the study explores how visual aesthetics, emotional atmospheres, and narrative structures encode environmental values such as balance, restraint, and care. Rather than measuring audience impact, the paper interprets Filipino online audience commentary as illustrative reception discourse reflecting how viewers emotionally interpret these mediated landscapes. Anchored in theories of soft power, cultural proximity, and …

Puberty In Down Syndrome, Katie Frank, Hannah Graham Md

Advocate GME

Puberty is a normal part of growth and maturation that comes with its own challenges. People with Down syndrome experience many of the same challenges as individuals without Down syndrome but may require additional supports to understand and accept the changes that puberty brings. In this webinar, Hannah Graham, MD, and Katie Frank, PhD, OTR/L, will describe how puberty in people with Down syndrome is similar and different to puberty in people without Down syndrome and share resources to support individuals with Down syndrome during this time of transition.

Limited Predictive Value Of Vaginal Discharge And Cervical Ectropion For Chlamydia Trachomatis Infection Detected By Direct Immunofluorescence, Dian Novitasari, Willy Sandhika, Ashon Sa'adi, Lusiani Tjandra

Folia Medica Indonesiana

Chlamydia trachomatis is one of the most common sexually transmitted infections, often asymptomatic, yet a major cause of infertility. In clinical practice, vaginal discharge and cervical ectropion are frequently used as syndromic indicators. However, their predictive value for Chlamydia trachomatis infection remains limited, particularly in regions with restricted access to NAAT/PCR, such as Indonesia. This study aimed to evaluate the diagnostic value of vaginal discharge and cervical ectropion as predictors of Chlamydia trachomatis infection using the Direct Immunofluorescence (DIF) method. This study used a cross-sectional design conducted among 93 reproductive-aged women from coastal areas of Jember, East Java, Indonesia, who …

Patterns Recognized In Ayres Sensory Integration®: A Scoping Review, Marica Botha, Janine Van Der Linde, Zoe Mailloux

Department of Occupational Therapy Faculty Papers

Background/Objectives: Associations between scores on tests of sensory integration functions demonstrated in numerous studies over six decades have contributed to the development of Ayres Sensory Integration® (ASI) theory and practice. Understanding these "patterns" aids therapists in their interpretation of assessment results, ensuring appropriate and effective intervention. This study aimed to describe and discuss published research on identified patterns related to constructs in the Ayres Sensory Integration® approach. Methods: Arksey and O'Malley's framework and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews Checklist were used. The literature review search was guided by the following …

Close To Home? Five Key Facts About Child Care Customer And Worker Commutes, Gabrielle Pepin, Jonathan Borowsky, Elizabeth E. Davis, Aaron Sojourner

Upjohn Institute Working Papers

Parents often cite location and convenience as important factors in choosing a child care provider. We use data on individual mobility from GPS in cell phones to study commutes to each licensed early childhood care and education (ECE) provider in 14 states separately for center customers, center workers, and customers of home-based child care providers. We document five key facts about ECE customer and worker commutes. One, center customers and workers commute farther than home-based customers to ECE providers. Two, substantial shares of customers and workers commute 10+ miles to their ECE provider. Three, commute distances to ECE providers vary …

Workforce Readiness And The Humanities: Building Internship Pathways In Slavic And East European Studies, Ani Kokobobo

Russian Language Journal

As workforce readiness becomes an increasingly central metric for evaluating academic programs, humanities disciplines, particularly small language and area studies fields such as Slavic, East European, and Eurasian Studies (SEEES), face growing pressure to demonstrate measurable employment outcomes. Drawing on national and state-level workforce policy frameworks, employer competency data, and the author’s administrative experience as Dean of Liberal Arts, this article argues that SEEES programs are uniquely positioned to meet contemporary career readiness mandates without compromising their intellectual and civic missions. The article reframes SEEES not as an at-risk humanities field, but as a high-value incubator of precisely the competencies …

Redesigning Our Curricula To Foster Career Readiness, Benjamin Rifkin

Russian Language Journal

Undergraduate majors are not engraved in stone; curricula have been adjusted and changed over the course of the history of higher education and now is the time to change our curricula once again. This article proposes a reconceptualization of the undergraduate major in Russian away from the framework of “coverage of the humanistic canon” to a framework focusing on the development of transferable or durable skills, i.e., skills that can be deployed in numerous employment contexts throughout an individual’s career trajectory to support career-readiness, in accordance with powerful frameworks offered by prominent educational organizations. This approach helps us support the …

What Do Learners Do With A Foreign Language After Their Studies? A Survey Of Alumni Of A Russian Summer Immersion Program, Dmitrii Pastushenkov, Liya Zalaltdinova, Jason Merrill

Russian Language Journal

Responding to concerns about the long-term value of foreign language education, this exploratory survey-based study examines how Russian language learners (N = 321) continued to use the language after completing a summer immersion program. The study investigates language use in personal and professional contexts and identifies resources alumni used, recommended, and needed to maintain proficiency. Although opportunities for conversational practice were limited, and interaction in Russian was one of the activities alumni needed but often viewed as unattainable, about 60% of participants continued using Russian at least occasionally. Among those employed full time, 24% used Russian frequently, primarily in …

High-Fidelity Simulation Training With Multisource Media Integration For Emergency Medicine: A Comprehensive Assessment Of Learning Motivation And Self-Reported Confidence In Perceived Clinical Competencies, Yung-Chi Hsu, Cheng-Yi Chao, Wei-Hung Chan, Yao-Chia Liu, Wei-Cheng Tseng, Chun Lun Hsu, Jen-Jiuan Liaw

Journal of Medical Education

Background: High-fidelity simulation has become essential in medical education, yet integration with advanced multimedia technologies remains underexplored. This study evaluated the effectiveness of combining high-fidelity simulation with multisource media systems (HFS-MMS) on emergency medicine residents' learning motivation and clinical competencies.
Methods: This quasi-experimental pre-post study included 72 postgraduate year-1 residents (74.2% completion rate) participating in technology-enhanced emergency medicine training. The intervention integrated high-fidelity simulation with comprehensive multimedia capabilities including multi-angle video recording, instant replay, mobile accessibility, and social learning platforms. Participants engaged in intensive 2-hour group training sessions featuring standardized emergency scenarios with progressive complexity. Outcome measures included validated assessments …

Advancing Medical Education Scholarship: A New Milestone For The Journal Of Medical Education, Huey-Ling Chen

Journal of Medical Education

No abstract provided.

Evolution Of Respiratory Therapist Training In Taiwan: A 17-Year Journey From Legislation To Competency-Based Education, Wei-Jhen Wang, Cheng-Heng Liu, Yun-Ting Tseng, Yi-Ting Hung, Hui-Jiuan Chen, Yao-Wen Kuo, Huey-Ling Chen

Journal of Medical Education

Respiratory therapist (RT) training in Taiwan has evolved over two decades, progressing from legislative foundation to a competency-based education framework. The Respiratory Therapists Act, promulgated in 2002, formalized the profession and mandated national licensure. Subsequently, university-level programs emerged, replacing hospital-based training. To bridge the gap between academic preparation and clinical demands, a nationwide two-year post-graduate year (PGY) training program was implemented in 2007, currently delivered across 13 accredited training institutions. Through the institutional experience of National Taiwan University Hospital (NTUH), presented as an illustrative case study, we describe a 17-year, feedback-driven process of continuous improvement encompassing 16 curriculum revisions. Recent …

Problem-Based Learning In Mackay Medical University: Improvement From Student-Initiated Assessment, I-Ling Huang, Yi-Chieh Cheng, Chao-Feng Lin

Journal of Medical Education

Statement of purpose: In Problem-Based Learning (PBL), aligning student self-directed inquiry with intended curricular objectives is critical yet challenging to assess. This study introduces a novel assessment method using keyword identification to quantify the cognitive alignment between medical students and case writers. We aimed to analyze learning discrepancies and students' performance trajectories to inform curriculum refinement.
Methods of study: A mixed cross-sectional and longitudinal study was conducted at MacKay Medical University over three consecutive semesters (November 2023–December 2024). Junior and senior medical students completed anonymous questionnaires, submitting five keywords post-course to represent perceived learning objectives. Student responses were compared against …

Still Chilly? Intersecting Inequalities In The Hidden Curriculum Faced By Female Medical Students, Hsing-Chen Yang

Journal of Medical Education

Background: Feminist scholars have used the term ``chilly classroom'' to describe the marginalization of women in higher education. The present study investigated female medical students' experiences with and strategies for coping with the chilly classroom in the ``hidden curriculum'' of unspoken gender and class norms.
Methods: Qualitative semistructured interviews were conducted with 20 female medical students (Years 1–6) of a Taiwanese university; the interviews were recorded, and the transcripts were subjected to thematic analysis.
Results: Three themes emerged from the interviews: (1) culture of hierarchical interactions, (2) family privilege and exclusive access to resources, and (3) gender discrimination and perpetuation …

Developing Entrustable Professional Activities For Entry-Level Dietitians: A Nationwide Consensus Study In Taiwan, Meng-Chuan Huang, Su-E Kuo, Hui-Ping Chang, Hsiu-Yueh Su, Huei-Min Linda Chin, Chiao-I Chang, Chih-Wei Yang

Journal of Medical Education

Background: Entrustable professional activities (EPAs) translate competency-based education into observable workplace tasks. This study aimed to develop EPAs for entry-level dietitians in Taiwan using a nationwide consensus-based approach.
Methods: A three-phase design was applied: (1) job analysis to identify core tasks; (2) three national workshops with 101 experts to draft EPAs; and (3) two consensus meetings with 29–30 experts using structured focus group discussions (FGDs) with anonymous voting to finalize the EPA framework and EPA/competency matrix. Consensus was defined as ≥ 50% agreement.
Results: In Phase 1, candidate EPAs were identified through job analysis and expert ratings, with items achieving …