Digital Commons Network^™

Let's Talk About Sex, Baby! Gender Roles In Parent-Child Sexual Communication, Alexandra Henrici

Dissertations and Theses

Parent-child sexual communication remains a fruitful avenue to increase safe sex behaviors, which are currently in decline by today's adolescents. Historically, mothers have reported engaging in parent-child sexual communication more than fathers do. Previous scholarship suggests this difference could be due to traditional gender role beliefs or conflicts with traditionally masculine attributes. Using social cognitive theory and social role theory, this study conducted a cross-sectional survey on parents of children aged 9 through 16. Positive relationships existed between outcome expectations, self-efficacy, and level of detail in sexual and reproductive health conversations between parents and children. Though no statistical difference was …

Veterans In Utah: Services, Gaps, And Opportunities, Troy Allan

All Current Publications

This fact sheet, the first in a series, provides an overview of veteran services in Utah, identifying existing resources, areas of unmet need, and opportunities for strategic investment. It is intended for veterans, policymakers, community leaders, and organizations committed to strengthening the health and well-being of Utah’s veteran community, with particular attention to those aging in rural and underserved areas.

Deficiency Of T Follicular Helper Cell Tet3 Dna Demethylation Inhibits Pathogenic Igg2c Class Switching And Chronic Gvhd, Michael C Zaiken, Sujeong Jin, Cameron S Mcdonald-Hyman, Christina R Hartigan, Peter T Sage, Keli L Hippen, Brent H Koehn, Angela Panoskaltsis-Mortari, Megan J Riddle, Cindy R Eide, Jakub Tolar, Geoffrey R Hill, Leo Luznik, Corey S Cutler, Jerome R Ritz, Leslie S Kean, Ageliki Tsagaratou, Anjana Rao, Bruce R Blazar

Faculty, Staff and Students Publications

Chronic graft-versus-host disease (cGVHD) is the leading cause of morbidity and nonrelapse-associated mortality after allogeneic hematopoietic cell transplantation. Treating steroid resistant/refractory cGVHD remains challenging. Epigenetic regulators can have global transcriptional effects that control donor T-cell responses. We previously showed that inhibiting histone lysine motifs by chromatin-modifying enzymes can ameliorate murine cGVHD. Targeting donor T-cell DNA methyltransferases reduce acute GVHD. In this study, we sought to investigate the DNA demethylase ten-eleven translocase (Tet) methylcytosine dioxygenases 2 (Tet2) and 3 (Tet3) in T follicular helper cell (TFH)-dependent cGVHD. In a clinically relevant model of cGVHD that recapitulates pulmonary fibrosis from bronchiolitis obliterans, …

Online Hyperparameter Tuning For Llm Optimization, Ethan Lin, Nathan Yu, Jeromy Chang

Computer Science and Engineering Senior Theses

Large Language Models (LLMs) are becoming increasingly popular in modern society. However, despite their popularity, the deployment of LLMs in real-world scenarios is extremely challenging due to substantial computational costs and memory constraints. Edge devices, like smartphones and IoT devices, lack resources needed to run these models locally, instead offloading computations for cloud computing. Cloud computing requires users to send their data over the internet leading to numerous privacy and security concerns. In some domains, such as health and finances, sending such sensitive information is not an option. Existing solutions to compress or increase inference speed include Small Language Models …

Loss Of Neuropeptide F (Npf) Signaling Reduces The Strength Of Circadian Rest-Activity Rhythms But Not Feeding-Fasting Rhythms, Katelyn Ann Wendt

Master's Theses

The circadian system governs crucial physiological and behavioral processes, dictating activities like movement, hormone release, and sleep patterns over a 24-hour cycle. Disruptions to these rhythms can lead to various health problems, including cardiometabolic dysfunction. Research has demonstrated the presence of circadian rhythms of feeding behavior in diverse organisms, but the specific molecules involved are not yet identified. Neuropeptide Y (NPY) influences metabolic activity in mammals, and its counterpart, NPF, affects locomotor activity and feeding in Drosophila melanogaster. Our study aims to investigate whether NPF, its receptor (NPFR), and NPF-expressing cells play a role in regulating circadian rest-activity and feeding-fasting …

Associations Between 24-Hour Movement Compositions And Cardiometabolic Health In Children And Adolescents: A Five-Part Compositional Analysis Using Data From The International Children’S Accelerometery Database (Icad), Zoë A. Marshall, Adam Runacres, Pedro Curi Hallal, Russ Jago, Soyang Kwon, Kate Northstone, Russell R. Pate, Jardena Puder, John J. Reilly, Luis B. Sardinha, Niels Wedderkopp, Ester Van Slujis

Faculty Publications

Objectives The benefits of physical activity (PA) and the negative impacts of sedentary time (SED) on health in youth are well established. However, uncertainty remains surrounding how PA and SED jointly influence cardiometabolic risk (CMR) factors. The aim of this study was to determine the joint influence of SED, light-, moderate- and vigorous-intensity PA (LPA, MPA and VPA), and sleep on CMR factors using five-part compositional analyses.

Methods Data were pooled from 16 cohort studies comprising 22 474 children and adolescents from the International Children’s Accelerometery Database. PA was measured using hip-mounted accelerometers with sleep self-reported. CMRs included body mass …

Enzymatic Characterization Of Bacterial Enzymes And Inhibitors As Potential Antibiotics With New Mechanisms Of Action, Emma Helene Kelley

Dissertations

Bacteria have become increasingly resistant to antibiotics, therefore there is an urgent need for new drug classes of antibiotics to help fight antibiotic infections. To this end, our research is focused on inhibitors of dizinc metalloenzymes N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), an enzyme in the lysine biosynthesis pathway, N-acetyl-L-ornithine deacetylase enzyme (ArgE), an enzyme in the arginine biosynthesis pathway, and sodium-dependent NADH: ubiquinone oxidoreductase (Na+-NQR) enzyme, a respiratory complex enzyme as promising drug targets. DapE, ArgE, and Na+-NQR and are only present in bacteria, including ESKAPE pathogens that can cause potentially deadly infections, thus inhibitors of DapE, ArgE, and Na+-NQR offer …

Balancing Health Information-Seeking Through Retrieval-Augmented Generation-Based Llm Chatbot, Gargi Nandy, Srishti Gupta, Farhad Mohammad Afzali, Eric Peeples, Betsy Pilon, Chun-Hua Tsai

Information Systems and Quantitative Analysis Faculty Publications

Family caregivers play a vital role in supporting children with chronic health conditions, such as neonates diagnosed with hypoxic-ischemic encephalopathy (HIE). However, navigating complex medical information can be overwhelming due to the quantity and quality of available literature. This study leverages Retrieval-Augmented Generation (RAG)-based Large Language Models (LLMs) to develop a chatbot that integrates peer-reviewed scientific literature and provides personalized, simplified summaries for caregivers. A user study involving six caregivers and five healthcare providers demonstrated the chatbot’s ability to enhance clarity, improve comprehension, and deliver essential medical information concisely. Our findings highlight the potential of RAG-based LLMs to enhance caregivers’ …

Balancing Health Information-Seeking Through Retrieval-Augmented Generation-Based Llm Chatbot, Gargi Nandy, Srishti Gupta, Farhad Mohammad Afzali, Eric Peeples, Betsy Pilon, Chun-Hua Tsai

Information Systems and Quantitative Analysis Faculty Publications

Family caregivers play a vital role in supporting children with chronic health conditions, such as neonates diagnosed with hypoxic-ischemic encephalopathy (HIE). However, navigating complex medical information can be overwhelming due to the quantity and quality of available literature. This study leverages Retrieval-Augmented Generation (RAG)-based Large Language Models (LLMs) to develop a chatbot that integrates peer-reviewed scientific literature and provides personalized, simplified summaries for caregivers. A user study involving six caregivers and five healthcare providers demonstrated the chatbot’s ability to enhance clarity, improve comprehension, and deliver essential medical information concisely. Our findings highlight the potential of RAG-based LLMs to enhance caregivers’ …

The Rogue Private Company And National Defense Emergencies, Gavin Small

Duke Journal of Constitutional Law & Public Policy Sidebar

This Note explores two overlapping challenges in the United States constitutional and political system. First, the United States increasingly relies on private companies for technologies necessary for national defense. This has given outsized power to a few unelected corporations and people who might have their own incentives that misalign with those of the United States. This is particularly dangerous in an emergency situation where the United States government, not a private company with its own interests, should be making decisions regarding national security. As an example, this Note focuses on the massive role that the company SpaceX plays in the …

Forcing Our Hand: Evaluating The Use Of Force In Responses To Wrongful Detentions Abroad, Tyler J. Marovitz

Duke Journal of Constitutional Law & Public Policy Sidebar

Wrongful detentions are on the rise. Over the past ten years, U.S. nationals have increasingly found themselves detained abroad upon spurious allegations, facing trumped-up charges, and deprived of basic due process protections. Most of these detentions occur in countries hostile to the United States: Russia, Iran, North Korea, China, and Venezuela. The U.S. has opted to release rightfully detained foreigners to those nations in exchange for its wrongfully detained nationals. All of this perpetuates a “prisoner bazaar” that encourages unscrupulous nations to continue their bad-faith detentions of U.S. nationals. This Note investigates this emerging issue through a use of military …

Stepping Into Motherhood: Pregnancy-Induced Changes To Foot Structure And Biomechanics, Lauren R. Williams

Theses and Dissertations

INTRODUCTION: Pregnant women have an elevated risk of developing lower limb musculoskeletal disorders, likely due to the rapid increase in body mass and joint laxity. While a few studies have evaluated changes in static foot posture due to pregnancy, it is unclear if body mass or joint laxity is the primary driver. Additionally, how pregnancy affects the mechanics of the foot during dynamic movements is still not understood. PURPOSE: The purpose of this study is to investigate the foot's response to pregnancy. First, we examined foot tissue characteristics across pregnancy, specifically plantar fascia (PF) stiffness, length, and thickness. Additionally, we …

News You Can Use: Shining A Light On Home Security Cameras, Jordan Karnbach

University of Mississippi News

OXFORD, Miss. – From autonomous driving to personal health monitoring, AI-powered vision systems are transforming how machines understand human behavior.

Common Aav Gene Therapy Vectors Show Nonselective Transduction Of Ex Vivo Human Brain Tissue, J P Mcginnis, Joshua Ortiz-Guzman, Maria Camila Guevara, Sai Mallannagari, Benjamin D W Belfort, Suyang Bao, Snigdha Srivastava, Maria Morkas, Emily Ji, Angela Addison, Evelyne K Tantry, Sarah Chen, Ying Wang, Zihong Chen, Kalman A Katlowitz, Jeffrey J Lange, Melissa M Blessing, Carrie A Mohila, M Cecilia Ljungberg, Guillermo Aldave, Ali Jalali, Akash Patel, Sameer A Sheth, Howard L Weiner, Shankar Gopinath, Ganesh Rao, Akdes Serin Harmanci, Daniel J Curry, Benjamin R Arenkiel

Children’s Nutrition Research Center Staff Publications

The ability to deliver a therapeutic sequence to a specific cell type in the human brain would make possible innumerable therapeutic options for some of our most challenging diseases; however, studies on adeno-associated virus (AAV) vector tropism have generally relied on animal models with limited translational utility. For this reason, establishing the tropism of common adeno-associated virus (AAV) vectors in living human brain tissue serves as an important baseline for further optimization, as well as a determination of human brain cell types transduced by clinically approved gene therapy vectors AAV2 and AAV9. We have adapted an

Beyond Criminalization: A Call For Educational Restorative Justice In Response To Maryland’S 2024 Juvenile Crime Bill, Melissa B. Spirn

Maryland Law Review Online

No abstract provided.

Abortion Regulation And Chilling From Extremists, Guha Krishnamurthi

Maryland Law Review Online

No abstract provided.

Imprudent Mootness: Why Federal Appellate Courts Should Abandon The Doctrine Of Prudential Mootness,, Cooper C. Millhouse

Maryland Law Review Online

No abstract provided.

A Mismatched Pair Of Sox: The Split Over The Whistleblower Exhaustion Requirement, Nikhil B. Mathur

Maryland Law Review Online

No abstract provided.

Multimodal Person Evaluation: First Impressions From Faces, Voices, And Names, Mila Mileva

School of Psychology

We form a first impression every time we meet someone unfamiliar to us. When this happens, we often have access to information about this person’s appearance, voice and the first thing we learn about them is usually their name. Despite this, much of what we know about social evaluation processes has been almost exclusively based on facial information. Here, approximately 45,000 spontaneous first impression descriptors were sampled to identify the most common judgements we make when presented with information about someone’s face, voice, and name at the same time as well as when presented with information about their voice or …

Predictive Analysis Of Crash Severity And Modeling Of 85th Percentile Speed For Rural Highways Of Arkansas Using Artificial Intelligence (Ai), Sagun Basel

Student Theses and Dissertations

Crash severity is a significant aspect of transport safety as its contributing factors assist engineers and designers in designing safer roads. The focus of this project is to predict crash severity, analyze crash parameters, and modeling of the 85th percentile speed (V85) selected rural roads (i.e., Interstate-555, East Johnson Avenue Highway, and Red Wolf Blvd) in Arkansas, using Artificial Neural Network (ANN) models. MATLAB® was used to predict the V85 and compare it with the actual V85 collected from field instrumentation. Besides the speed data, weather (e.g., rainfall), road geometry, light conditions, and traffic volume were used as input in …

Teacher Perspectives On The Impact Of School-Based Mental Health Services On Academic Performance, Attendance, And Behavior, Carol Ingram

Student Theses and Dissertations

This qualitative instrumental case study explores teacher perspectives on the impact of school-based mental health services on student academic performance, attendance, and behavior in a northern Mississippi school district. Understanding their influence on key student outcomes is crucial given the increasing integration of school-based mental health services in educational settings. Framed by the Collaborative for Academic, Social, and Emotional Learning (CASEL) five core competencies, this study examines how school-based mental health services support these competencies through teachers' insights. Data were collected using criterion sampling, focusing on eight high school teachers through focus groups, individual interviews, and a review of the …

A New Model For Educational Program Assessments Using Automated Collective Concept Maps, Andrew R. Paullin

Master's Theses (2009 -)

This paper presents: Epistemological principles; the origins and theoretical foundations of concept maps; the current state of related works; the contributions, methods, results, and future road map of this research; and A New Model for Educational Program Assessments. An understanding that knowledge results from an evolution of cognitive structures enables a scientific approach to enhance the efficiency of learning. Building on prior works, this research provides a novel algorithm and tool to automatically create Collective Concept Maps from Individual Concept Maps by utilizing a dictionary, thesaurus, Natural Language Processing, Machine Learning / Artificial Intelligence, and domain expertise. Abstraction Filters enable …

Arkansas High School Teacher Perceptions About Declining Enrollment And Learning Experiences In Advanced Science Courses, Tanya Lynette Ruble

Student Theses and Dissertations

Student enrollment in advanced high school science courses in Arkansas, specifically Chemistry, Physics, AP Biology, AP Chemistry, and AP Physics has declined since 2014. Colleges across the nation recommend that students take Biology, Chemistry, and Physics in high school to prepare for rigorous science majors in college. Decreased enrollment in these subjects can lead to fewer college science majors and impact the preparation of students for careers in STEM fields such as engineering and healthcare. This qualitative phenomenological study utilized three research questions to explore the reasons for the decline in advanced high school science course enrollment in Arkansas. It …

Bias In Media Portrayals Of Filicide Cases Involving African American Women, Channing Lelar Collins

Walden Dissertations and Doctoral Studies

This study was conducted to examine racial disparities in media portrayals of filicide cases involving African American and Caucasian women, exploring how systemic biases and societal narratives influenced public perception, policy, and the child welfare and legal systems. Using a qualitative content analysis of 42 cases involving African American women and 20 involving Caucasian women, framing techniques, language, and imagery were analyzed. The research addressed three questions were (a) What narratives and framing were used?, (b) How did these differ across racial lines?, and (c) What are the broader societal and systemic implications? Results showed that media coverage of African …

Older Adults' Experiences Of Telephone-Delivered Behavioral Activation With Mental Imagery As A Treatment For Depression During The Covid-19 Pandemic: A Qualitative Study, Johnny Pellas, Mattias Damberg, Fritz Renner, Julie L Ji, Marie Kivi

School of Psychology

The COVID-19 pandemic prompted the use of telehealth interventions for treating depression in older adults. We conducted a pilot study of a telephone-based brief psychological intervention, Behavioral Activation with Mental Imagery (BA-MI), for the treatment of depression in isolated older adults during the COVID-19 pandemic. We achieved promising results regarding a reduction in depressive symptoms. The purpose of the present study was to investigate the participants' experiences of the intervention and provide insight into how the intervention could be improved. Fourteen participants aged 67-85 years that completed the BA-MI intervention were purposively selected and interviewed. The interviews were analyzed using …

Yield And Pungency Of Eight Onion Varieties And Their Response To Sulfur Fertilizer On Fine-Textured Soil, Charlie Rohwer, Jesen Hosch, Brianna Hayward, Cindy Tong

Midwest Vegetable Trial Reports

Onions are notable for their pungency, caused by sulfur-containing compounds. Fine-textured soils high in organic matter, or soils fertilized with organic amendments, are unlikely to require additional sulfur for maximum onion yield. We were interested in the impacts of additional sulfur (in such a situation, unlikely to be sulfur-limited) on pungency, soluble solids, and yield in eight onion varieties. We carried out a study in 2024 in southern Minnesota, designed as a split-plot (onion variety as the whole-plot) with four replicates. Heavy rainfall caused substantial unmarketability in our trial, with ‘Ringmaster’ suffering the most loss (11% of planted ‘Ringmaster’ were …

Strengthening Global Health Education In The Uae: Assessing The Current Landscape And Future Directions, Ali Artaman, Hillani T. Bekele, Ross Millar

All Works

Global health is a growing area of interest for the United Arab Emirates (UAE). Given its location in the Middle East and its geographical proximity to developing sub-Saharan countries, the country is in a strategic position to contribute to global health agendas. Yet despite an increasing emphasis on global health policy, the availability of global health education programs at UAE universities remains limited. The aim of this Perspective is to raise awareness and understanding about the importance of the issue. Reflecting on the current landscape, it argues that it is crucial for higher education institutions in the UAE to better …

Revising And Consolidating The Dsm-5 And Icd-11 Post-Traumatic Stress Disorders Into A Dimensional Spectrum-Based Disorder: A Literature Review, Samuel Milton Shatsky

University Honors Theses

This thesis investigates the clinical, cultural, and theoretical implications of replacing the current DSM-5 and ICD-11 categorical diagnoses of posttraumatic stress disorder (PTSD) and complex posttraumatic stress disorder (CPTSD) with a unified dimensional framework: trauma spectrum disorder (TSD). The proposed TSD model addresses ongoing concerns around diagnostic inflation, treatment misalignment, and clinical confusion stemming from binary trauma categorizations. This thesis explores whether adopting a dimensional diagnostic model to replace DSM-5 and ICD-11's current PTSD and CPTSD designations could lead to improved treatment outcomes and diagnostic clarity.

Methodology consisted of an extensive literature review of the field's current research. Using the …

Evaluation Of Aav Vectors With Tissue-Specific Or Ubiquitous Promoters In A Mouse Model Of Mucopolysaccharidosis Type Iva, Shaukat A. Khan, Jose Victor Álvarez, F. N. U. Nidhi, Eliana Benincore-Florez, Shunji Tomatsu

Department of Pediatrics Faculty Papers

Mucopolysaccharidosis type IVA (MPS IVA) is caused by a deficiency of N-acetyl-galactosamine-6-sulfate sulfatase (GALNS), leading to the accumulation of keratan sulfate and chondroitin-6-sulfate and development of severe skeletal dysplasia. Enzyme replacement therapy and hematopoietic stem cell transplantation are current treatment options but have limited impact on bone lesions. In this study, we investigated adeno-associated virus (AAV)8 or AAV9 vectors with liver-specific thyroxine-binding globulin or liver-specific promoter-a modification of hAAT (LSPX), liver-muscle tandem (LMTP), liver-bone tandem (LBTP), and ubiquitous cytomegalovirus early enhancer/chicken β-actin (CAG) promoters in MPS IVA mice to compare therapeutic efficacy on biochemical markers and bone pathology. All vectors …

Interactive Module's Effectiveness On Empathy And Attitudes Of Healthcare Students, Jacob Linomaz, Desmond Chee, Jana L. Wardian, Elizabeth Beverly, Shelene Thomas

Journal Articles: Hospital Medicine

CONTEXT: As the prevalence of social determinants of health (SDH) continues to have an impact on the management of chronic conditions, it is imperative to expose health professional students to these encounters.

OBJECTIVES: This study investigates the role that virtual interactive modules play on osteopathic medical students and physician assistant (PA) students' empathy and attitudes toward individuals with diabetes mellitus who are also affected by an array of SDHs.

METHODS: Students from both health professional programs were asked to complete a pre-survey and post-survey that encompassed the Diabetes Attitude Scale, the Jefferson Empathy Scale, and the Assessing Student Competence and …