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Is It Time To Scrap Stare Decisis?, Wilfred U. Codrington Iii

Articles

Shortly after returning to the presidency, Donald Trump terminated several independent federal officers, prompting legal action by employees who occupied government positions covered by statutory for cause removal protections long held constitutionally permissible and valid. Eventually, one or more suits alleging unlawful termination owing to the removal without cause will reach the Supreme Court to be decided on the merits. Having steadily narrowed the Humphrey’s Executor line of cases that insulate these officers, the Court now seems poised to displace that precedent entirely. In isolation, the overruling would mark a seismic doctrinal shift and major advance in legal conservatism's pursuit …

Combining Remote And Collaborative Research: A Critical Reflection On Large-Scale, Comparative, And Interdisciplinary Research In Times Of A Global Crisis, Ferdiansyah Thajib, Thomas Stodulka, Patricia Kanngiesser, Daniel Haun, Jahnavi Sunderarajan, Magie Junker, Tongtong Meng, Wanting Sun, Zhen Zhang, Sandra Masaquiza, Monika Swastyastu, Desri Julita Taek, Arianna Abis, Disney Tjizao, Denis Chishala, Ljubica Petrović, Blanca Striegler, Janina Weyrowitz, Bernardo Arroyo-Garcia, Katja Liebal

School of Psychology

This paper examines the methodological and ethical challenges of conducting remoteresearch on child-animal relationships across thirty communities in seventeen countriesduring the COVID-19 pandemic. It critically assesses remote research as a mode ofcollaboration informed by decolonial aspirations, highlighting the complexities of navigatingtemporal and geographical distances, mitigating global inequalities, and addressing politicaland methodological tensions at the intersection of psychological anthropology and crosscultural developmental psychology. By engaging with these challenges, the paper fosterscritical dialogue on research ethics and methodologies between anthropology andpsychology, advancing a broader intellectual engagement toward translocal equity

Re: Comment Letter For The Butte Priority Soils Operable Unit (Bpsou) 2022 Draft Final Insufficiently Reclaimed Sites Sampling: Bres No. 37 – Josephine Shaft Site Evaluation Summary Report (December 6, 2024), Molly Roby

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Building Models, Building Capacity: A Review Of Participatory Machine Learning For Hiv Prevention, Mark Sendak, Meg Young, Jee Young Kim, Alifia Hasan, Clare Kelsey, Catherine O’Neal, Tonya Jagneaux, Wayne Wilbright, John Couk, Stephen Lim, Tamachia Davenport, Shirley Lolis, Jennifer Thomas, Shannon Widman, Suresh Balu, Meredith Clement, Lance Okeke

School of Medicine Faculty Publications

A growing number of researchers and practitioners are embracing a “participatory turn” in machine learning (ML) to improve model development, prevent harm, and provide communities more influence over systems that impact them. In this paper, we explore the intersection of participatory practices in healthcare and the emerging focus on responsible AI with a focus on human immunodeficiency virus (HIV) care. We review the historical context of participation in HIV treatment and prevention, emphasizing how patient activism has shaped practices in this field. We then review participatory ML in HIV prevention and present a brief case study of a project designed …

Study Of Capital And Operation Costs For Reverse Osmosis Desalination Plants, Habiba Mahdy Mohamed

Theses and Dissertations

Desalination is a progressively common solution to supply freshwater in numerous parts of the globe where this resource falls short. Among all desalination techniques, seawater reverse osmosis (SWRO) is the most globally prevalent technology. Evaluating a desalination technology's cost-effectiveness is essential to ensure a well-designed plant can be implemented successfully and within an acceptable budget. In the Egyptian context, where water scarcity heightens the urgency of effective resource allocation, economic indicators such as capital expenditure (CAPEX) and operational expenditure (OPEX) are pivotal in shaping policy and planning decisions. Adopting this integrated financial perspective ensures that desalination projects are not only …

60-15 Woodside Avenue V. Leen

All Decisions

The court granted summary judgment to the tenant, allowing her to succeed to the rent-controlled tenancy. The tenant demonstrated a long-term emotional and financial interdependence with the deceased tenant of record, her aunt, and established that the subject premises was her primary residence for the required period. The landlord did not provide sufficient rebuttal.

Linking Dna Methylation In Brain Regions To Alzheimer’S Disease Risk: A Mendelian Randomization Study, Hua Zhong, Jingjing Zhu, Shuai Liu, Dan Zhou, Quan Long, Chong Wu, Bingxin Zhao, Chao Cheng, Yaohua Yang, Qing Wu, Yong Wu, Changwei Li, Zhaoming Wang, Jianyong Wu, Xingyi Guo, Degui Zhi, Youping Deng, Lang Wu

Faculty, Staff and Students Publications

Aim: DNA methylation in brain regions represents a potential mechanism linking genetic variation to Alzheimer's disease (ad) risk, yet most studies have focused on blood-derived methylation markers. In this study, we conducted a systematic Mendelian randomization (MR) study to evaluate associations between predicted brain region-specific DNA methylation levels and ad risk, using methylation quantitative trait loci (mQTL) as genetic instruments.

Methods: We analyzed mQTLs from five human brain regions: cerebellum (CRBLM), frontal cortex (FCTX), causal pons (PONS), and temporal cortex (TCTX) from 600 individuals in Gibbs et al's study, as well as mQTLs from dorsolateral prefrontal cortex (DLPFC) of 543 …

Telehealth And In-Person Hiv Care During The Covid-19 Pandemic At A Large Academic Medical Center In North Carolina, Valerie Yelverton, Jan Ostermann Ph.D., Michael E. Yarrington, Andrew K. Weinhold, Nabil Natafgi, Bankole Olatosi, Sharon Weissman, Nathan M. Thielman

Faculty Publications

Background

To maintain HIV care during the COVID-19 pandemic, many HIV clinics across the United States adopted telehealth. However, not everyone participated in telehealth equally. This study assessed the use and disparities in telehealth and in-person HIV care at a large academic medical center in North Carolina (NC) relative to the COVID-19 pandemic.

Methods

Data from the Duke University Infectious Disease clinic in NC were extracted from electronic health records (EHR), aggregated across persons with HIV (PWH) by calendar month, visit type (in-person vs. telehealth HIV care), and by key sociodemographic and clinical characteristics. Variation in HIV care over time …

Response To Comment Letter For The Butte Priority Soils Operable Unit (Bpsou) Butte Reclamation Evaluation System (Bres) Draft 2024 Field Evaluation Summary And Technical Recommendations Report (Dated April 10, 2025), Abby Peltomaa

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Sunrise At The Salton Sea: Environmental Justice, Land Use Change, And Hydrosocial Dynamics Of Solar Energy Transitions In The Imperial Valley, California, Dustin Mulvaney, James J. A. Blair, Alida Cantor

Geography Faculty Publications and Presentations

California's Imperial Valley, with lithium-rich geothermal brines, extensive flat agricultural fields with abundant desert sunshine, and access to transmission lines, is a leading case to explore interconnected themes around just energy transitions. Despite being the poorest county in California and one of the smallest, Imperial already provides 15% of the state’s solar electricity, and the region as a whole represents on the order of 25% of the state’s electric power capacity. This paper brings to light frictions over solar energy development that have emerged over the history of solar power development in the southern Salton Sea region. It describes the …

Antifungal Efficacy And Flexural Strength Of Silver Nanoparticles Reinforced Cad/Cam And Heat-Cured Pmma Polymers: An In-Vitro Study, Himanshi Aggarwal

All ETDs from UAB

Background: PMMA denture base resins have high propensity for C. albicans growth. Previous studies have found that silver nanoparticle (SNP) addition into conventional PMMA resin improves fungal resistance without interfering with its flexural strength. Recently, CAD/CAM dentures have become highly popular, but they are also prone to fungal in-growth. However, little is known about the effect of addition of silver nanoparticles in CAD/CAM printed PMMA resin material. Objective: To compare the effect of the addition of cytocompatible concentration (1 µm/ml) of SNP on the antifungal efficacy and flexural strength of CAD/CAM printed and heat-cured PMMA polymers. Materials and methods: A …

Balancing The Clinical Response To Sleep Disturbance In Adults 65 And Older, Katherine C. Ward

All ETDs from UAB

Older adults are more likely to have symptoms of insomnia than other age ranges. Ensuring an appropriate clinical response to insomnia in older adults is vital to their health and well-being. This paper addresses the assessment and treatment of insomnia symptoms in older adults in two separate studies analyzing data from the AMBulatoRy blOod preSsure In older Adults (AMBROSIA) study, which recruited older adults (≥65 years old) who had hypertension and were living in Southern California. The first study aimed to investigate the ability of the insomnia severity index (ISI), a standard self-report measure used to assess insomnia symptoms, to …

Assessing Awareness And Use Of Library Services Within Chinese Partner Academic Programs: A Case Study Developing And Analyzing Bilingual Surveys, Maryalice Wade, Claire Nickerson, Heather P. Vandyne, Cyndi Landis

Library Faculty Publications

A library at a regional comprehensive university created a Global Access Committee to provide support for students and faculty at two international partner campuses in China. In 2022, the committee sent out a survey to these students to assess their awareness, usage, and satisfaction with library resources and services. Students reported high awareness, usage, and satisfaction with online library resources, instructional materials such as guides and tutorials, and the library’s Ask A Librarian service. However, there was a discrepancy between students’ self-reported usage and usage statistics collected by the library. The responses may have been influenced by cultural differences and …

177lu-Labeled Antibody-Drug Conjugate: A Dual-Mechanistic Treatment Modality In Solid Tumors, Aiko Yamaguchi, Chisato M Yamazaki, Yasuaki Anami, Summer Y Y Ha, Wei Xiong, Robert T Ta, Ningyan Zhang, H Charles Manning, Zhiqiang An, Kyoji Tsuchikama

The Brown Foundation: Institute of Molecular Medicine

To explore the potential of site-selectively radiolabeled antibody-drug conjugates (ADC) against solid tumors, we constructed and evaluated radiolabeled ADCs equipped with lutetium-177 (177Lu) and a membrane-permeable antimitotic agent. Site-selective 177Lu-labeled ADCs [anti-trophoblast cell-surface antigen 2 (TROP2) 177Lu-DTPA ADCs or anti-HER2 177Lu-DO3A ADCs], a 177Lu-labeled homogeneous radioimmunoconjugate (homogeneous RIC), and 177Lu-labeled conventional RIC (heterogeneous RIC) were constructed. We confirmed that 177Lu-labeled ADCs and the homogeneous RIC were obtained with high homogeneity and defined chelator/payload-to-antibody ratios. Next, we performed biodistribution studies and treatment efficacy studies in xenograft mouse models bearing orthotopic breast tumors. Compared with the heterogeneous RIC, the 177Lu-DTPA TROP2 ADC …

Nurse Led Staff Education Program For Workplace Stress Reduction, Ebony Sudduth

Walden Dissertations and Doctoral Studies

This doctoral project evaluated the impact of a staff education program aimed at increasing healthcare workers' awareness of workplace stress dangers among teammates in an outpatient hemodialysis center. The identified practice issue was limited knowledge about the facilitators, adverse outcomes, and resources related to occupational stress in healthcare. Lack of education regarding the risks of work-related stress presents a critical concern in nursing practice, significantly affecting caregiver well-being and patient outcomes. Nurses, particularly in high-pressure environments such as hemodialysis centers, often experience unrecognized and unmanaged emotional and physical demands, leading to chronic stress and burnout. Hemodialysis nurses are especially susceptible …

An Exploration Of The Lived Experiences Of Black Female Kinship Caregivers In Parenting Youth Aged 13-18, Tyla Wilder

Walden Dissertations and Doctoral Studies

This qualitative phenomenological study explored how the intersection of identities related to race and gender shapes the lived experiences of Black female kinship caregivers raising youth aged 13–18. Drawing on Intersectionality Theory, the study sought to understand the caregiving challenges, emotional resilience, and systemic barriers encountered by this underrepresented population. Nine participants were recruited through purposive and snowball sampling and engaged in in-depth semi-structured interviews. Thematic analysis revealed that cultural norms and racialized gender expectations often compelled Black females to assume caregiving roles without institutional recognition or support. Participants described emotional isolation, financial instability, and limited access to legal and …

Advances In Molecular Imaging Of Vegfrs: Innovations In Imaging And Therapeutics, Hanieh Karimi, Sarah Lee, Wenqi Xu, Sigrid A. Langhans, David K. Johnson, Erik Stauff, Heidi H. Kecskemethy, Lauren W. Averill, Xuyi Yue

Department of Radiology Faculty Papers

Vascular endothelial growth factor receptors (VEGFRs) are key regulators of angiogenesis, lymphangiogenesis, and vascular permeability, playing essential roles in both physiological and pathological processes. The VEGFR family, including VEGFR-1, VEGFR-2, and VEGFR-3, interacts with structurally related VEGF ligands (VEGFA, VEGFB, VEGFC, VEGFD, and placental growth factor [PlGF]), activating downstream signaling pathways that mediate critical cellular processes, including proliferation, migration, and survival. Dysregulation of VEGFR signaling has been implicated in numerous diseases, such as cancer, cardiovascular conditions, and inflammatory disorders. Targeting VEGFRs with radiopharmaceuticals, such as radiolabeled peptides, antibodies, and specific tracers like 64Cu-bevacizumab and 89Zr-ramucirumab, has emerged as a powerful …

Re: Approval Letter For The Butte Priority Soils Operable Unit (Bpsou) Draft Final 2025 Residential Metals Abatement Program (Rmap) Rock Creek Cattle Company Borrow Submittal #1 (Dated May 23, 2025), Molly Roby

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Autism Spectrum Disorder-Specific Knowledge And Self-Efficacy Among Early Interventionists In Alabama, Greta R. Conlon

All ETDs from UAB

Young children diagnosed with autism and those who will go on to receive an autism diagnosis are frequently enrolled in early intervention services under Part C of IDEA. ASD-specific knowledge and self-efficacy have been shown to vary among providers working with autistic children, including those providing early intervention services (i.e., early interventionists). The current study aimed to characterize ASD-specific knowledge and self-efficacy in a sample of early interventionists in Alabama. In addition, it sought to identify differences in knowledge and self-efficacy between early interventionists serving different roles and to identify predictors of identified knowledge levels and self-efficacy ratings among participants. …

Development Of Aldot's Worker Safety Assessment, Risk Identification, And Control Program, Lana Marji

All ETDs from UAB

This research examines the safety challenges faced by Transportation Maintenance Technicians (TMTs) at the Alabama Department of Transportation (ALDOT). By ana-lyzing extensive injury data from 2009 to 2024, along with insights from surveys and interactions with ALDOT personnel, this effort highlights significant trends and relation-ships among injury characteristics such as nature, cause, source, and affected body parts. The findings reveal considerable costs and productivity losses associated with common injury types that warrant the need for targeted interventions. By reviewing successful safety programs across various state Departments of Transportation (DOTs), the study identifies opportunities to enhance safety within ALDOT. This effort …

Best Practices For Preparing Urban High School Students For College Readiness, Chin Nou Khang

Graduate Teacher Education

Low-income urban students in the United States exhibit limited college and career readiness opportunities (Yavuz et al., 2019). College preparation coursework and career training in low-income urban secondary settings are essential to creating inclusivity in education. The disparities of marginalized students in these institutions highlight the urgency for educational leaders to effectively produce the next generation of student achievement. This meta-analysis secondary research paper examined the best practices for educational leaders to ensure college and career readiness opportunities are being implemented for low-income urban high school students. When students have access to college readiness materials, their scholastic goals can be …

Association Between Microsatellite Loci And Body Weight Over Generations Of Selection For Growth In Local Selected Chicken Lines, Mariam S. Orabi, Essam A. El-Gendy, Ahmed M. El-Kaiaty, Ellham H. Abbas, Marwa M. Ahmed, Mostafa M. Helal

Turkish Journal of Veterinary & Animal Sciences

The genetic improvement of local chicken breeds is essential for sustainability and adaptability. Marker-assisted breeding can increase the response to selection; however, it requires the identification of marker associations with different traits. Therefore, the current study aimed to evaluate the association between microsatellite marker alleles and the body weight of juvenile chicks over three subsequent generations. Ten microsatellites were used to genotype four chicken lines (two selected and two randombred) across three generations. The lines included the normally feathered selected line (CE1), the normally feathered randombred line (CE2) used as a genetic control for CE1, the naked-neck selected line (CE3), …

Nitrate And Nitrite Levels In Cattle Feed, Drinking Water, Rumen Content, And Blood Methemoglobin Levels In Burdur Province Of Türkiye, Reyda Kiyici, Hasan Altan Akkan, Mehmet Karaca, Esra Zeybek, Bayram Kudret Karaayvaz, Fi̇rdevs Mor Savaş, Yahya Öztürk, Asim Kart, Ramazan Yildiz, Murat Bayezi̇t

Turkish Journal of Veterinary & Animal Sciences

This study was conducted to determine the risk factors associated with nitrate/nitrite poisoning in cattle in the Burdur region. Feed and water samples were collected from 10 different farms randomly selected from 9 districts. A total of 33 feed samples, 13 water samples, 21 rumen contents, and 20 blood samples were collected for analysis. Nitrate and nitrite levels in feed, drinking water, and rumen fluid, as well as methemoglobin levels in blood samples, were determined using a spectrophotometric method. The average nitrate and nitrite levels in feed samples were 3.06 mg/kg and 3.54 mg/kg, respectively. The mean nitrate and nitrite …

Deep Learning Based Rapid X-Ray Fluorescence Signal Extraction And Image Reconstruction For Preclinical Benchtop X-Ray Fluorescence Computed Tomography Applications, Amrit Kaphle, Sandun Jayarathna, Sang Hyun Cho

Faculty, Staff and Student Publications

Recent research advances have resulted in an experimental benchtop X-ray fluorescence computed tomography (XFCT) system that likely meets the imaging dose/scan time constraints for benchtop XFCT imaging of live mice injected with gold nanoparticles (GNPs). For routine in vivo benchtop XFCT imaging, however, additional challenges, most notably the need for rapid/near-real-time handling of X-ray fluorescence (XRF) signal extraction and XFCT image reconstruction, must be successfully addressed. Here we propose a novel end-to-end deep learning (DL) framework that integrates a one-dimensional convolutional neural network (1D CNN) for rapid XRF signal extraction with a U-Net model for XFCT image reconstruction. We trained …

Olaparib And Radiotherapy Induce Type I Interferon- And Cd8+ T Cell-Dependent Sensitization To Immunotherapy In Pancreatic Cancer, Victoria M Valvo, Qiang Zhang, Long Jiang, Erin A Holcomb, Ashley N Pearson, Anna G Edmunds, Hailey G Faulkner, Jadyn G James, Akshay Tate, Amanda K Huber, Zhuwen Wang, Yupei Guo, David Karnak, Leslie A Parsels, Joshua D Parsels, Yu L Lei, Alnawaz Rehemtulla, Heng Lin, Eileen S Carpenter, Daniel R Wahl, Vaibhav Sahai, Theodore S Lawrence, Michael D Green, Meredith A Morgan

Faculty, Staff and Student Publications

PARP inhibitors sensitize pancreatic ductal adenocarcinoma (PDAC) to radiation by inducing DNA damage and replication stress. These mechanisms also have the potential to enhance radiation-induced type I interferon (T1IFN) mediated anti-tumoral immune responses. We hypothesized that the PARP inhibitor olaparib would also potentiate radiation-induced T1IFN to promote anti-tumor immune responses and sensitization of otherwise resistant PDAC to immunotherapy. To test this hypothesis, we assessed the effects of olaparib and radiation on T1IFN production and sensitivity to αPD-L1 immunotherapy, as well as on the tumor microenvironment by single-cell RNA sequencing (scRNA-seq). We found that olaparib enhanced T1IFN production following radiation and …

Polygenic Scores For Obstructive Sleep Apnoea Reveal Pathways Contributing To Cardiovascular Disease, Nuzulul Kurniansyah, Satu J Strausz, Geetha Chittoor, Shreyash Gupta, Anne E Justice, Yana Hrytsenko, Brendan T Keenan, Brian E Cade, Brian W Spitzer, Heming Wang, Jennifer Huffman, Matthew R Moll, Bernhard Haring, Su Yon Jung, Laura M Raffield, Robert Kaplan, Jerome I Rotter, Stephen S Rich, Sina A Gharib, Traci M Bartz, Peter Y Liu, Han Chen, Myriam Fornage, Lifang Hou, Daniel Levy, Alanna C Morrison, Heather M Ochs-Balcom, Bruce M Psaty, Peter W F Wilson, Kelly Cho, Allan I Pack, Hanna M Ollila, Susan Redline, Daniel J Gottlieb, Tamar Sofer

Faculty, Staff and Student Publications

Background: Obstructive sleep apnoea (OSA) is a common chronic condition, with obesity its strongest risk factor. Polygenic scores (PGSs) summarise the genetic liability to phenotype and can provide insights into relationships between phenotypes. Recently, large datasets that include genetic data and OSA status became available, providing an opportunity to utilise PGS approaches to study the genetic relationship between OSA and other phenotypes, while differentiating OSA-specific from obesity-specific genetic factors.

Methods: Using race/ethnic diverse samples from over 1.2 million individuals from the Million Veteran Program, FinnGen, TOPMed, All of Us (AoU), Geisinger's MyCode, MGB Biobank, and the Human Phenotype Project, we …

Lmp7-Specific Inhibitor M3258 Modulates The Tumor Microenvironment Of Triple-Negative Breast Cancer And Inflammatory Breast Cancer, Xuemei Xie, Jangsoon Lee, Ganiraju C Manyam, Troy Pearson, Gina Walter-Bausch, Manja Friese-Hamim, Sheng Zhao, Julia Jabs, Angela A Manginelli, Nadine Piske, Thomas Mrowiec, Corinna M Wolf, Bharat S Kuntal, Debu Tripathy, Jing Wang, Michael P Sanderson, Naoto T Ueno

Faculty, Staff and Student Publications

Triple-negative breast cancer (TNBC) and inflammatory breast cancer (IBC) are the most aggressive molecular subtypes of breast cancer. Poor clinical outcomes highlight the pressing need to discover novel targets for the effective treatment of these diseases. LMP7 (β5i/PSMB8), a proteolytic subunit of the immunoproteasome, is implicated in the pathogenesis of multiple myeloma, autoimmune and inflammatory diseases, and inflammation-related cancers. However, the role of LMP7 in TNBC and IBC remains poorly characterized. Here, we evaluated the function of LMP7 in TNBC and IBC using the selective LMP7 inhibitor M3258. In human TNBC patient samples, LMP7 expression correlated strongly with CD8+ T …

Eph Receptors Activate Myeloid Checkpoint Receptor Lilrb5 To Support Tumor Development, Yubo He, Chengcheng Zhang, Lingxiao Tan, Mi Deng, Xiaoye Liu, Ryan Huang, Xing Yang, Jingjing Xie, Qi Lou, Meng Fang, Caroline Smith, Samuel John, Wei Xiong, Xin Li, Cheryl Lewis, Jade Homsi, Ankit Gupta, Ningyan Zhang, Zhiqiang An, Cheng Cheng Zhang

Faculty, Staff and Student Publications

Immunosuppressive myeloid cells are critical obstacles to T cell-centered immune checkpoint blockade therapies, which have been successful in treating a fraction of patients with cancer. How tumor cells interact with myeloid cells to regulate immune responses and tumor development is unclear. In this study, we report that certain membrane tyrosine kinase Eph receptors, including EphA7 and EphB1, specifically bind the immune inhibitory receptors leukocyte Ig-like receptor family B 5 (LILRB5) and LILRB2. These Eph receptors induce LILRB5-mediated signaling activation, and LILRB5 also activates Eph receptor signaling. Activation of LILRB5 promoted immunosuppressive marker expression and inhibited activating marker expression on myeloid …

The Present And Future Of Precision Oncology And Tumor-Agnostic Therapeutic Approaches, Nakul M Shah, Funda Meric-Bernstam

Faculty, Staff and Student Publications

Precision oncology has transformed the treatment landscape for patients with advanced solid tumors. Tumor-agnostic therapies, those that have been approved based on genetic mutations or biomarkers across tumor histology types, are important examples of how the implementation of precision oncology can expand therapeutic options for patients, especially those with rare cancer types and treatment-refractory disease. In this review, we first discuss how advances in next-generation sequencing and molecular profiling have enabled the identification of shared actionable alterations. Subsequently, we explore the current landscape of tumor-agnostic therapies that have received approval from the Food and Drug Administration. We discuss the strengths …

Deep Learning Based Rapid X-Ray Fluorescence Signal Extraction And Image Reconstruction For Preclinical Benchtop X-Ray Fluorescence Computed Tomography Applications, Amrit Kaphle, Sandun Jayarathna, Sang Hyun Cho

Faculty, Staff and Student Publications

Recent research advances have resulted in an experimental benchtop X-ray fluorescence computed tomography (XFCT) system that likely meets the imaging dose/scan time constraints for benchtop XFCT imaging of live mice injected with gold nanoparticles (GNPs). For routine in vivo benchtop XFCT imaging, however, additional challenges, most notably the need for rapid/near-real-time handling of X-ray fluorescence (XRF) signal extraction and XFCT image reconstruction, must be successfully addressed. Here we propose a novel end-to-end deep learning (DL) framework that integrates a one-dimensional convolutional neural network (1D CNN) for rapid XRF signal extraction with a U-Net model for XFCT image reconstruction. We trained …