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Support Beyond Services: Examining The Role Of Neighbor Relationships, Housing Staff, And Place In Mental Health Recovery, Kenna Estell Dickard Jun 2025

Support Beyond Services: Examining The Role Of Neighbor Relationships, Housing Staff, And Place In Mental Health Recovery, Kenna Estell Dickard

Dissertations and Theses

This dissertation explores the role of non-clinical support for individuals with serious mental illness (SMI). Through three interconnected manuscripts, this dissertation highlights the importance of housing staff support, places in the community, and neighbor relationships in fostering recovery for individuals with SMI. The first manuscript analyzes how housing staff support influences residents' well-being through an ecological lens. This study found that staff support is associated with reduced loneliness, higher residential satisfaction, and increased sense of community. This study also considers the role of self-determination as a moderator, demonstrating the importance of resident agency in maximizing well-being outcomes. The second manuscript …


Reproductive Rights At Work: The Role Of Organizations In Menstrual Support, Emily Julia Ready Jun 2025

Reproductive Rights At Work: The Role Of Organizations In Menstrual Support, Emily Julia Ready

Dissertations and Theses

Painful menstrual symptoms affect up to 90% of people with uteruses globally. These symptoms can result in lost productivity at work and absenteeism for working individuals. Normative work structures have not been designed with accessibility and inclusivity for those with uteruses in mind. Therefore, women and those with uteruses have often had to work through barriers with no accommodations or systematic change. Currently, there is no published research in the United States on the nuances of the relationship between menstruation and work with the intention of exploring effective solutions. There has been discussion related to menstrual supportive policies, but there …


Boys In A Box: A Mixed Methods Study Examining The Masculinity Of Boys In A Private School, Shavar Ryan Bernier Jun 2025

Boys In A Box: A Mixed Methods Study Examining The Masculinity Of Boys In A Private School, Shavar Ryan Bernier

Dartmouth College Master’s Theses

My name is Shavar Bernier, and the title of my thesis is Boys in a box: mixed methods study examining boys' masculinity in a private boarding school. I wrote the paper with guidance from my advisors and readers at Dartmouth, Mary Turco, Andrew Garrod, and Douglas Moody.

This mixed-methods study examined masculinity and how it was displayed at a private boarding school in Watertown, Connecticut. The purpose of the study was to use the experiences of students and teaching faculty to understand how masculinity was evident on Taft’s campus. The study participants consisted of 15 former students and forty-five teaching …


New Student Orientation Programs: Understanding The Perceptions And Experiences Of First-Generation Community College Students, April J. Catching Jun 2025

New Student Orientation Programs: Understanding The Perceptions And Experiences Of First-Generation Community College Students, April J. Catching

Theses and Dissertations

This study examines first-generation community college students' perceptions of New Student Orientation programs. The research questions focus on specific aspects of students' experiences and transitions to gain an understanding of their perspectives. The objective is to see if there is a connection between what researchers ascertain are the most valuable experiences for new students and what students feel and perceive while enrolled in their first semester of college. Qualitative data was collected to provide targeted insights for improving orientation programs and practices. The research questions focused on understanding specific aspects of students’ orientation experiences and their impact on their college …


Can Social And Emotional Lessons Improve Student Behavior In A First Grade Classroom? A Program Evaluation, Tara Freeman Mozee Jun 2025

Can Social And Emotional Lessons Improve Student Behavior In A First Grade Classroom? A Program Evaluation, Tara Freeman Mozee

Theses and Dissertations

This program evaluation discusses how using a social and emotional (SEL) curriculum taught first-grade students how to manage and regulate their behavior in a first-grade classroom. The purpose of this program evaluation was to evaluate if the SEL curriculum helped first-grade students manage and regulate their behavior in the classroom so the teacher would create fewer behavior management plans and spend more time on classroom instruction. The methodology used in this program evaluation was a logic model. This model presented the inputs, activities, outputs, and outcomes of the program evaluation. The implications of this program evaluation are based on the …


Enhancing Gpr Reliability For Concrete Infrastructure: Integrating Signal Processing And Deep Learning For Defect And Corrosion Assessment, Priyam Chowdhury Jun 2025

Enhancing Gpr Reliability For Concrete Infrastructure: Integrating Signal Processing And Deep Learning For Defect And Corrosion Assessment, Priyam Chowdhury

Theses and Dissertations

This research addresses the critical issue of deteriorating civil infrastructure by utilizing GPR integrated with advanced signal processing and machine learning. Employing the Conquest 100 system, four concrete slab configurations were tested: multi-layer rebar with defects, single- and double-layer rebar setups, varied rebar spacing, and pre-corroded rebars (0–30% mass loss). GPR B-scans collected over 3–60 days demonstrated that detection accuracy varied significantly with curing time, structural complexity, and moisture levels. A custom-developed Python script surpassed EKKO_Project software in rebar localization, achieving lower position errors (0.4–0.7 inches compared to 0.5–1.25 inches). Notably, the amplitude of GPR signals unexpectedly increased with corrosion …


Voluntary Contractions Underestimate Peak Muscle Activity In Drop Jumps, David Alan Phillips, Skylar Paletta, Michael R. Perlet Jun 2025

Voluntary Contractions Underestimate Peak Muscle Activity In Drop Jumps, David Alan Phillips, Skylar Paletta, Michael R. Perlet

Department of Kinesiology Scholarship and Creative Works

Maximal voluntary isometric contractions (MVIC) are a common method to normalize electromyographic amplitude into standardized units of %MVIC. However, in 60% of drop jump research using an MVIC in 2018–2023, supramaximal activation or activation greater than 100% MVIC occurred. Therefore, MVICs may not be representative of peak muscle activation, leading to erroneous interpretation of muscle activation. The purpose of this study is to quantify EMG normalization difference in drop jump landings. Sixteen (10 M, 6F) participants were recruited for the study. MVICs were recorded from nine lower extremity muscles and this activation compared to the maximal activation recorded from 10 …


Sea Cucumbers Could Hold Key To Stopping Cancer Spread, Clara Turnage Jun 2025

Sea Cucumbers Could Hold Key To Stopping Cancer Spread, Clara Turnage

University of Mississippi News

OXFORD, Miss. – Sea cucumbers are the ocean's janitors, cleaning the seabed and recycling nutrients back into the water. But this humble marine invertebrate could also hold the key to stopping the spread of cancer.


Critical Race Theory And Higher Education In Ireland: An Exploration Of The Experiences Of Black Minority Ethnic Social Care Students, Margaret Fingleton Jun 2025

Critical Race Theory And Higher Education In Ireland: An Exploration Of The Experiences Of Black Minority Ethnic Social Care Students, Margaret Fingleton

Irish Journal of Academic Practice

This paper examines the experiences of Black Minority Ethnic students studying in higher education in Ireland, contextualizing them by key global events that occurred over the last decade. The research was underpinned by the core principles of Critical Race Theory (CRT) with a particular focus on the tenets of storytelling and intersectionality. Based on a qualitative approach, a participatory research methodology informed all phases of the study. Using a combined semi-structured interview/storytelling method, twenty-one female social care students in five higher education institutions participated in the study. In collaboration with a participatory advisory group, reflective thematic analysis was utilised to …


Couples And Pornography: A Dyadic Latent Profile Analysis Of Romantic Partners And Pornography Use, Michelle E. Haddock Edwards Jun 2025

Couples And Pornography: A Dyadic Latent Profile Analysis Of Romantic Partners And Pornography Use, Michelle E. Haddock Edwards

Theses and Dissertations

Research on the outcomes of pornography use for romantic couples has been extensive yet inconclusive. Studies have examined pornography use in a wide variety of contexts, leading to a wide variety of outcomes and well-being. The current study uses latent profile analysis to account for many contextual factors at once, dyadic data to examine the perspective of both partners simultaneously, and a range of individual and relational well-being outcomes to understand how different relational pornography use patterns lead to well-being. Results provided evidence for six unique profiles of couples based on pornography use patterns (personal use frequency, perceived partner use …


Competition In The Global Law Market: Offshore Development Of The Statutory "Rule In Hastings-Bass", Andrew P. Morriss Jun 2025

Competition In The Global Law Market: Offshore Development Of The Statutory "Rule In Hastings-Bass", Andrew P. Morriss

Minnesota Journal of International Law, Vols. 28:2 onward (2019-present)

This Article examines the competitive dynamics in the global law market through the lens of the statutory evolution of the Rule in Hastings-Bass across various International Financial Centers (IFCs). Following the UK Supreme Court’s 2013 decision in Pitt v Holt and Futter v Futter, which significantly restricted the judiciary’s ability to void trustee decisions under the Rule, seven IFCs (Jersey, Bermuda, The Bahamas, the Dubai International Financial Center, the Cayman Islands, and the British Virgin Islands) enacted statutes to preserve and clarify the Rule within their jurisdictions. These legislative actions highlight the strategic adaptations by IFCs to enhance their legal …


Establishing A "Duty To Not Destroy": Using Fiduciary Duty To Hold Settler-Colonial States Responsible For Cultural And Linguistic Harms Committed Against Indigenous Students At Government-Run Boarding Schools, Kristina Mclaughlin Jun 2025

Establishing A "Duty To Not Destroy": Using Fiduciary Duty To Hold Settler-Colonial States Responsible For Cultural And Linguistic Harms Committed Against Indigenous Students At Government-Run Boarding Schools, Kristina Mclaughlin

Minnesota Journal of International Law, Vols. 28:2 onward (2019-present)

No abstract provided.


And They Would Have Gotten Away With It, If Not For Those Meddling Federales: Examining State Responses To Transnational Organized Crime And Developing A Policy Framework, Aaron Lutz Jun 2025

And They Would Have Gotten Away With It, If Not For Those Meddling Federales: Examining State Responses To Transnational Organized Crime And Developing A Policy Framework, Aaron Lutz

Minnesota Journal of International Law, Vols. 28:2 onward (2019-present)

Transnational criminal organizations (TCOs) have begun expanding their enterprise into criminal gold mining in South America. This is causing widespread harm from human trafficking, pollution, and disease. These groups exploit vulnerable artisanal miners (ASMs) to provide a foothold in the gold mining industry and avoid the reach of states. This note examines the policy responses that South American countries have taken to this phenomenon and develops a policy framework for state actors moving against TCOs.


Influence Of Filler Content And Polishing On Candida And Streptococci Biofilm Formation In Resin-Based Composites: An In Vitro Evaluation, Zahra Zareshahrabadi, Sarina Sahmeddini, Marzieh Meimandinezhad, Afsoon Tondari, Kamiar Zomorodian Jun 2025

Influence Of Filler Content And Polishing On Candida And Streptococci Biofilm Formation In Resin-Based Composites: An In Vitro Evaluation, Zahra Zareshahrabadi, Sarina Sahmeddini, Marzieh Meimandinezhad, Afsoon Tondari, Kamiar Zomorodian

Pacific Faculty Work

Aim: The purpose of this study was to investigate the impact of filler content and polishing of resin-based composites on in vitro biofilm formation of Candida and Streptococci species. Materials and Methods: Specimens of four commercially available resin-based composites including Z100, P60, Z250, and Z350, with different filler amounts and volumes, were prepared according to the manufacturer’s instructions. Each group was divided into polished and unpolished specimens, which were then placed in a 24-well tissue culture plate with microbial suspension and incubated. The XTT technique was used to evaluate biofilm formation. Results: Z250 resin-based composites, which had the highest percentage …


Community Perspectives On Cancer And Cancer Research: Findings From Listening Sessions With Diverse Groups In Philadelphia, Karen Glanz, Emma A. Soliva, Krista Scheffey, Yawei Song, Charnita Zeigler-Johnson, Evelyn T. González, Thierry Fortune, Nilsa Graciani, Amy E. Leader Jun 2025

Community Perspectives On Cancer And Cancer Research: Findings From Listening Sessions With Diverse Groups In Philadelphia, Karen Glanz, Emma A. Soliva, Krista Scheffey, Yawei Song, Charnita Zeigler-Johnson, Evelyn T. González, Thierry Fortune, Nilsa Graciani, Amy E. Leader

Kimmel Cancer Center Faculty Papers

BACKGROUND: Listening sessions are useful for understanding community perspectives on cancer disparities. The Philadelphia Communities Conquering Cancer (PC3) coalition conducted listening sessions to identify community priorities for cancer prevention and control research among diverse communities in Philadelphia.

METHODS: Guided by a Stakeholder Advisory Committee, PC3 partnered with community-based organizations to conduct 8 listening sessions with diverse communities (including Black, Hispanic, Asian, Russian, LGBTQ + , and veterans) to learn about perceptions of cancer, research priorities, and training and communication preferences. Sessions were facilitated by community members or PC3 members in the primary language of participants. Sessions were audio recorded, transcribed, …


Determining Accurate Pore Structures Of Polypropylene Membrane For Ecmo Using Fe-Sem Under Optimized Conditions, Makoto Fukuda, Yoshiaki Nishite, Eri Murata, Koki Namekawa, Tomohiro Mori, Tsutomu Tanaka, Kiyotaka Sakai Jun 2025

Determining Accurate Pore Structures Of Polypropylene Membrane For Ecmo Using Fe-Sem Under Optimized Conditions, Makoto Fukuda, Yoshiaki Nishite, Eri Murata, Koki Namekawa, Tomohiro Mori, Tsutomu Tanaka, Kiyotaka Sakai

Children’s Nutrition Research Center Staff Publications

Long-term ECMOs are expected to be put into practical use in order to prepare for the next emerging severe infectious diseases after the novel coronavirus pandemic in 2019-2023. While polypropylene (PP) and polymethylpentene (PMP) are currently the mainstream materials for the hollow fiber membranes of ECMO, the PP membrane coated with a silicone layer on the outer surface has also been commercialized. In this study, we sought a method to accurately observe the detailed pore morphologies of the PP membrane by suppressing irreversible changes in the morphology in SEM observation, which is a general-purpose observation with higher resolution. As a …


Incorporating Propensity Score Weighting And Nonresposne Adjustments Into Complex Survey Data With Survival Outcomes, Xinrui Shi Jun 2025

Incorporating Propensity Score Weighting And Nonresposne Adjustments Into Complex Survey Data With Survival Outcomes, Xinrui Shi

Theses and Dissertations

Propensity score weighting (PSW) plays a key role in minimizing confounding in observational research, especially when estimating treatment effects for time-to-event outcomes. However, its integration into survey data with complex design – particularly data with multiple stage sampling and censoring – remains underexplored. One significant challenge in such settings is the presence of nonresponse, which can introduce additional bias and complicate the use of standard weight adjustments. Moreover, there has been limited study on how PS weights can be effectively combined with nonresponse weighting adjustments in complex survey data that include survival outcomes. This dissertation aims to extend current methodologies …


Case Report On Acute Hemorrhagic Acute Disseminated Encephalomyelitis (Adem) Following Parvovirus B19 Infection In An Immunocompetent Child, Akash Dnyandeo Sarkate, Sushma Save, Alpana Kondekar, Raja Rajan Jun 2025

Case Report On Acute Hemorrhagic Acute Disseminated Encephalomyelitis (Adem) Following Parvovirus B19 Infection In An Immunocompetent Child, Akash Dnyandeo Sarkate, Sushma Save, Alpana Kondekar, Raja Rajan

Digital Journal of Clinical Medicine

Acute disseminated encephalomyelitis (ADEM) is a rare, immune-mediated demyelinating disorder of the central nervous system, often triggered by viral infections. Parvovirus B19 has been implicated in various haematological and neurological manifestations; however, its association with acute hemorrhagic ADEM remains rare. Here, we report a case of a 5-year-old male immunocompetent child who developed ADEM following parvovirus B19 infection, emphasising the rarity of such presentations and the importance of early recognition and management.


Targeting Detoxifying Enzymes In The Lymphatic Filariasis Vector: An In Silico Study On Curcumin, Camphor, And Menthol, Rizal Subahar, Rawina Winita, Surya Dwira, Gulshan Fahmi El Bayani Jun 2025

Targeting Detoxifying Enzymes In The Lymphatic Filariasis Vector: An In Silico Study On Curcumin, Camphor, And Menthol, Rizal Subahar, Rawina Winita, Surya Dwira, Gulshan Fahmi El Bayani

Indonesian Journal of Medical Chemistry and Bioinformatics

Vector control remains a critical component in the prevention of lymphatic filariasis, a disease transmitted by insect vectors. Natural compounds such as curcumin, camphor, and menthol are being explored for their bio-insecticidal properties due to their potential to inhibit key detoxification and neurological enzymes in insects, including acetylcholinesterase (AChE), glutathione S-transferase (GST), and cytochrome P450 oxidases (CYP450). A molecular docking study using SwissDock was conducted to evaluate the interaction of curcumin, camphor, and menthol with AChE, GST, and CYP450 enzymes. Binding affinity (ΔG), hydrogen bonding, and active site interactions were analyzed to assess the inhibitory potential of each compound. Curcumin …


Current Rates And Trends Of Venous Thromboembolism After Total Hip And Knee Arthroplasty: An Updated Analysis Utilizing The Nsqip Database, Alexander Van Der Ven Jun 2025

Current Rates And Trends Of Venous Thromboembolism After Total Hip And Knee Arthroplasty: An Updated Analysis Utilizing The Nsqip Database, Alexander Van Der Ven

All Publications

Background: Total hip arthroplasty (THA) and total knee arthroplasty (TKA) procedure volumes are increasing. Venous thromboembolism (VTE) remains a significant complication, with incidence rates between 0.45% and 5.30%. Enhanced rapid-recovery pathways and chemoprophylaxis evolution may correlate with decreased VTE events over time. This study analyzes recent trends of VTE after THA and TKA.

Methods: Adults undergoing THA or TKA between 2009 and 2022 were identified from the National Quality Surgical Improvement Program database using Current Procedural Terminology codes. VTE was defined as the occurrence of a deep vein thrombosis (DVT) and/or pulmonary embolism (PE) event in the same patient. The …


Human Rights And Foreign Policy: South Africa's Genocide Complaint Against Israel At The International Court Of Justice, Penelope Andrews Jun 2025

Human Rights And Foreign Policy: South Africa's Genocide Complaint Against Israel At The International Court Of Justice, Penelope Andrews

Minnesota Journal of International Law, Vols. 28:2 onward (2019-present)

No abstract provided.


The 2025 Sc Teacher Working Conditions Survey, Ruiqin Gao, Angela Starrett, Brian Cartiff, Svetlana Dmitrieva Jun 2025

The 2025 Sc Teacher Working Conditions Survey, Ruiqin Gao, Angela Starrett, Brian Cartiff, Svetlana Dmitrieva

Reports

The SC Teacher Working Conditions Survey (SCTWCS) was developed to better understand teachers’ experiences in their schools and the factors that infl uence their workplace satisfaction and career decisions. SC TEACHER designed the SCTWCS to include 10 areas of working conditions—six resources and four demands—with job satisfaction and intent to stay in the profession as outcomes. For novice teachers, three areas of mentor support (mentor instructional support, mentor non-instructional support, and proximity) are also included.

In the 2025 administration, 54 of the state’s 72 traditional school districts (75%) participated, along with f i ve of the six specialty schools and …


Cultural Continuity And Identity Preservation In Diaspora: The Role Of African Pentecostal Churches In Maintaining Traditions Within African Communities In The United States, Olamide T. Awoyemi Jun 2025

Cultural Continuity And Identity Preservation In Diaspora: The Role Of African Pentecostal Churches In Maintaining Traditions Within African Communities In The United States, Olamide T. Awoyemi

USF Tampa Graduate Theses and Dissertations

This study explores the role of African Pentecostal churches in preserving cultural traditions andshaping identities among African diaspora communities in the United States, focusing specifically on Christ Apostolic Church (CAC) and Pentecost International Worship Centre (PIWC) in Tampa, Florida. Through detailed participant observation and in-depth qualitative interviews, this thesis examines how rituals, religious practices, and community engagement within these churches facilitate cultural continuity and identity negotiation among Nigerian and Ghanaian immigrants. Findings reveal that these religious institutions serve as critical sites for resisting cultural erasure, navigating the complex tensions between maintaining African heritage and adapting to American society, and providing …


Role Of Interventional Pulmonology In Intensive Care Units: A Scoping Review, Abdul Rahman R Halawa, Saad Farooq, Mohammad Asim Amjad, Pushan P Jani, Sujith V Cherian Jun 2025

Role Of Interventional Pulmonology In Intensive Care Units: A Scoping Review, Abdul Rahman R Halawa, Saad Farooq, Mohammad Asim Amjad, Pushan P Jani, Sujith V Cherian

Faculty, Staff and Student Publications

Interventional pulmonology (IP) represents a rapidly growing and developing subspecialty within pulmonary medicine. To the intensivist, given the elaborate undertakings with respect to airway, lung and pleural disease management-IP has shown an increasing presence and remain a major ally in the care of these patients. Thus, an understanding of the different roles that IP could offer to the intensivist is of prime importance in the multi-disciplinary care of the complex patients within the intensive care units, particularly in relation to lung, airway and pleural diseases. This review article will explore the different intersections of IP in critical care and discuss …


Radiotherapy Promotes Cuproptosis And Synergizes With Cuproptosis Inducers To Overcome Tumor Radioresistance, Guang Lei, Mingchuang Sun, Jun Cheng, Rui Ye, Zhengze Lu, Amber Horbath, David Huo, Shengrong Wu, Anagha Alapati, Sadhna Aggarwal, Zhihao Xu, Chao Mao, Yuelong Yan, Jun Yao, Qidong Li, Xiong Chen, Hyemin Lee, Li Zhuang, Dadi Jiang, Apar Pataer, Jack A Roth, Nicholas Navin, Albert C Koong, Mingjian James You, Steven H Lin, Boyi Gan Jun 2025

Radiotherapy Promotes Cuproptosis And Synergizes With Cuproptosis Inducers To Overcome Tumor Radioresistance, Guang Lei, Mingchuang Sun, Jun Cheng, Rui Ye, Zhengze Lu, Amber Horbath, David Huo, Shengrong Wu, Anagha Alapati, Sadhna Aggarwal, Zhihao Xu, Chao Mao, Yuelong Yan, Jun Yao, Qidong Li, Xiong Chen, Hyemin Lee, Li Zhuang, Dadi Jiang, Apar Pataer, Jack A Roth, Nicholas Navin, Albert C Koong, Mingjian James You, Steven H Lin, Boyi Gan

Faculty, Staff and Student Publications

Cuproptosis is a recently identified form of copper-dependent cell death. Here, we reveal that radiotherapy (RT) induces cuproptosis in cancer cells, independent of apoptosis and ferroptosis, and depletes lipoylated proteins and iron-sulfur (Fe-S) cluster proteins-both hallmarks of cuproptosis-in patient tumors. Mechanistically, RT elevates mitochondrial copper levels by upregulating copper transporter 1 (CTR1) and depleting mitochondrial glutathione, a copper chelator, thereby triggering cuproptosis. Integrated analyses of RNA sequencing (RNA-seq) from radioresistant esophageal cancer cells and single-cell RNA-seq from esophageal tumors of patients unresponsive to RT link radioresistance to the downregulation of BTB and CNC homology 1 (BACH1). This downregulation de-represses the …


Specialized Insectivores Drive Differences In Avian Community Composition Between Primary And Secondary Forest In Central Africa, Eleanor M. Barrie, Billi A. Krochuk, Crinan Jarrett, Diogo F. Ferreira, Patricia F. Rodrigues, Susana Lin Mufumu, Silvestre Esteban Malanza, Agustin Ebana Nsue Akele, Cayetano Ebana Ebana Alene, Kristin Brzeski, Jacob C. Cooper, Jared Wolfe, Luke L. Powell Jun 2025

Specialized Insectivores Drive Differences In Avian Community Composition Between Primary And Secondary Forest In Central Africa, Eleanor M. Barrie, Billi A. Krochuk, Crinan Jarrett, Diogo F. Ferreira, Patricia F. Rodrigues, Susana Lin Mufumu, Silvestre Esteban Malanza, Agustin Ebana Nsue Akele, Cayetano Ebana Ebana Alene, Kristin Brzeski, Jacob C. Cooper, Jared Wolfe, Luke L. Powell

Michigan Tech Publications

The human population of sub-Saharan Africa is projected to triple by 2100, drastically increasing anthropogenic pressure on biodiversity. When rainforest is disturbed by anthropogenic drivers, species respond heterogeneously; these patterns have rarely been quantified for Congo rainforest fauna. Our objective was to understand how community composition changed with human disturbance—with particular interest in the guilds and species that indicate primary rainforest. At a long-term bird banding site on mainland Equatorial Guinea, we captured over 3200 birds across 6 field seasons in selectively logged secondary forest and in largely undisturbed primary forest. Our multivariate ordination indicated a significant split between primary …


Radiotherapy Promotes Cuproptosis And Synergizes With Cuproptosis Inducers To Overcome Tumor Radioresistance, Guang Lei, Mingchuang Sun, Jun Cheng, Rui Ye, Zhengze Lu, Amber Horbath, David Huo, Shengrong Wu, Anagha Alapati, Sadhna Aggarwal, Zhihao Xu, Chao Mao, Yuelong Yan, Jun Yao, Qidong Li, Xiong Chen, Hyemin Lee, Li Zhuang, Dadi Jiang, Apar Pataer, Jack A Roth, Nicholas Navin, Albert C Koong, Mingjian James You, Steven H Lin, Boyi Gan Jun 2025

Radiotherapy Promotes Cuproptosis And Synergizes With Cuproptosis Inducers To Overcome Tumor Radioresistance, Guang Lei, Mingchuang Sun, Jun Cheng, Rui Ye, Zhengze Lu, Amber Horbath, David Huo, Shengrong Wu, Anagha Alapati, Sadhna Aggarwal, Zhihao Xu, Chao Mao, Yuelong Yan, Jun Yao, Qidong Li, Xiong Chen, Hyemin Lee, Li Zhuang, Dadi Jiang, Apar Pataer, Jack A Roth, Nicholas Navin, Albert C Koong, Mingjian James You, Steven H Lin, Boyi Gan

Faculty, Staff and Student Publications

Cuproptosis is a recently identified form of copper-dependent cell death. Here, we reveal that radiotherapy (RT) induces cuproptosis in cancer cells, independent of apoptosis and ferroptosis, and depletes lipoylated proteins and iron-sulfur (Fe-S) cluster proteins-both hallmarks of cuproptosis-in patient tumors. Mechanistically, RT elevates mitochondrial copper levels by upregulating copper transporter 1 (CTR1) and depleting mitochondrial glutathione, a copper chelator, thereby triggering cuproptosis. Integrated analyses of RNA sequencing (RNA-seq) from radioresistant esophageal cancer cells and single-cell RNA-seq from esophageal tumors of patients unresponsive to RT link radioresistance to the downregulation of BTB and CNC homology 1 (BACH1). This downregulation de-represses the …


Unsettling Home: Traces Of An Unrepaired Settler-Colonial Past In "Redding, California," 1846-1924, Celeste Hegy Jun 2025

Unsettling Home: Traces Of An Unrepaired Settler-Colonial Past In "Redding, California," 1846-1924, Celeste Hegy

University Honors Theses

This thesis critically reads primary documents from the settler-colonial past of "Redding, California," my hometown. In this paper, I sketch out a series of moments of historical trauma which continue to cry out for repair. Through a series of episodes from the mid-nineteenth through the early-twentieth centuries, I examine how original settler thirst for land wrought a contested hegemony in principally genocidal flows of power between the settler-state and its settler inhabitants and the pre-existing local Indigenous nations and peoples. In the first chapter, I argue for an understanding of the dispossession of the northern valley as genocidal. In the …


Draft Final 2025 Residential Metals Abatement Program (Rmap) Quality Assurance Project Plan (Qapp) Annual Update (Residential Parcels), Pioneer Technical Services, Inc. Jun 2025

Draft Final 2025 Residential Metals Abatement Program (Rmap) Quality Assurance Project Plan (Qapp) Annual Update (Residential Parcels), Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.


Cannabis Concentrate Vaping Chemistry, Kaelas R. Munger, Killian M. Anreise, Robert M. Strongin Jun 2025

Cannabis Concentrate Vaping Chemistry, Kaelas R. Munger, Killian M. Anreise, Robert M. Strongin

Chemistry Faculty Publications and Presentations

Background:

This review article addresses the vaping chemistry of manufactured cannabis concentrates—a topic that remains under-researched despite the widespread availability and growing popularity of these products. Given their current prevalence and the fact that many of the findings discussed herein are from early-stage investigations, further research is essential to fully assess the public health risks associated with concentrate use. The purpose of this article is to help begin to bridge this knowledge gap by outlining the technical challenges of studying cannabis concentrates and to present evidence-based data concerning toxicant exposures as a foundation for future investigations.

Methods:

A search of …