Digital Commons Network^™

Citrullinated Eno1 Vaccine Enhances Pd-1 Blockade In Mice Implanted With Murine Triple-Negative Breast Cancer Cells, Ricardo A León-Letelier, Alejandro M Sevillano-Mantas, Yihui Chen, Soyoung Park, Jody Vykoukal, Johannes F Fahrmann, Edwin J Ostrin, Candace Garrett, Rongzhang Dou, Yining Cai, Fu-Chung Hsiao, Jennifer B Dennison, Eduardo Vilar, Banu K Arun, Samir Hanash, Hiroyuki Katayama

Faculty, Staff and Student Publications

Background/Objectives:Cancer vaccine targets mostly include mutations and overexpressed proteins. However, cancer-associated post-translational modifications (PTMs) may also induce immune responses. Previously, our group established the enzyme protein arginine deiminase type-2 (PADI2), which catalyzes citrullination modification, is highly expressed in triple-negative breast cancer (TNBC), promoting antigenicity.

Methods: Here, we show the workflow of designing citrullinated enolase 1 (citENO1) vaccine peptides identified from breast cancer cells by mass spectrometry and demonstrate TNBC vaccine efficacy in the mouse model. Immunized mice with citENO1 peptides or the corresponding unmodified peptides, plus Poly I:C as an adjuvant, were orthotopically implanted with a TNBC murine …

Inactivation Of The Fusobacterium Nucleatum Rnf Complex Reduces Fada-Mediated Amyloid Formation And Tumor Development, Timmie A Britton, Ju Huck Lee, Chungyu Chang, Aadil H Bhat, Yi-Wei Chen, Rusul Mohammed Ali, Chenggang Wu, Asis Das, Hung Ton-That

Faculty, Staff and Student Publications

The Gram-negative anaerobe Fusobacterium nucleatum is an oral oncobacterium that promotes colorectal cancer (CRC) development with the amyloid-forming cell surface adhesin FadA integral to CRC tumorigenesis. We describe here molecular genetic studies uncovering a novel mode of metabolic regulation of FadA-mediated tumor formation by a highly conserved respiratory enzyme known as the Rnf complex. First, we show that genetic disruption of Rnf, via rnfC deletion, significantly reduces the level of fadA transcript, accompanied by a near-complete abolishment of the precursor form of FadA (pFadA), reduced assembly of FadA at the mature cell pole, and severe defects in the osmotic stress-induced …

The Incidence Of Peripartum Invasive Group A Streptococcal Infections And Association With Illicit Drug Use, Elizabeth Wagman, Elizabeth Wagman, Rupsa Boelig, Sarah Boudova

Department of Obstetrics and Gynecology Faculty Papers

No abstract provided.

Organizational Development At Milner Library: A Journey Of Transformation 2024-2025, Chloe Vicente, Susan Franzen

Milner Library Publications

This presentation was delivered at Milner Library on June 11, 2025 by Chloe Vicente, Fulbright Scholar-in-Residence, and Sue Franzen, Associate Dean of Public Services and Organizational Development.

Draft Final 2025 Residential Metals Abatement Program (Rmap) Quality Assurance Project Plan (Qapp) Annual Update (Non-Residential Parcels And Residential Daycares), Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Green Technologies For Isolating Bioactives From Plant-Based Food And Their Applications In Human Health And Longevity, Vibha Gajbe, Azza S. Naik, Roji Waghmare, Shuchi Midha

Research Outputs: 2025-Present

No abstract provided.

Mapping Vascular Network Architecture In Primate Brain Using Ferumoxytol-Weighted Laminar Mri, Joonas A Autio, Ikko Kimura, Takayuki Ose, Yuki Matsumoto, Masahiro Ohno, Yuta Urushibata, Takuro Ikeda, Matthew F Glasser, David C Van Essen, Takuya Hayashi

2020-Current year OA Pubs

Mapping the vascular organization of the brain is of great importance across various domains of basic neuroimaging research, diagnostic radiology, and neurology. However, the intricate task of precisely mapping vasculature across brain regions and cortical layers presents formidable challenges, resulting in a limited understanding of neurometabolic factors influencing the brain's microvasculature. Addressing this gap, our study investigates whole-brain vascular volume using ferumoxytol-weighted laminar-resolution multi-echo gradient-echo imaging in macaque monkeys. We validate the results with published data for vascular densities and compare them with cytoarchitecture, neuron and synaptic densities. The ferumoxytol-induced change in transverse relaxation rate (ΔR

Georgia Has A New Habitability Protection For Tenants, But What Does It Mean?, Elizabeth Grant, Gordon Wayne

Scholarly Works

Georgia’s Safe at Home Act became law on July 1, 2024, and established the standard that residential premises be “fit for human habitation.” The Act strengthens tenant protections by targeting severe housing issues affecting 15% of Georgia households, particularly Black and rural communities. It adds cooling as an essential utility, caps security deposits, and mandates a three-day notice to pay before eviction filings. However, the undefined “fit for human habitation” term awaits judicial interpretation, complicated by limited legal access and rare appellate precedent. Though a key step forward, this brief Comment suggests that additional measures are needed to secure tenants’ …

Parallel Use Of Low-Complexity Automated Nucleic Acid Amplification Tests On Respiratory And Stool Samples With Or Without Lateral Flow Lipoarabinomannan Assays To Detect Pulmonary Tuberculosis Disease In Children, Laura Olbrich, Bada Yang, Hayley Poore, Alia Razid, Brittney Sweetser, Mathias Weis Damkjær, Alexander W Kay, Johanna Åhsberg, Ruvandhi R Nathavitharana, Ian Schiller, Nandini Dendukuri, Andreas Lundh, Maunank Shah, Stephanie Bjerrum, Devan Jaganath

Faculty, Staff and Students Publications

Background: Low-complexity automated nucleic acid amplification tests (LC-aNAATs) are molecular assays widely used to diagnose tuberculosis disease in children. The lateral flow urine lipoarabinomannan assay (LF-LAM) is recommended for use amongst children with HIV. Previous systematic reviews have assessed the diagnostic accuracy of LC-aNAATs and LF-LAM separately in children, but in clinical practice the tests may be used concurrently, i.e. in 'parallel'.

Objectives: To compare the diagnostic accuracy of the parallel use of LC-aNAAT on respiratory and stool specimens in children, and with LF-LAM on urine amongst children with HIV, versus each assay alone for detecting pulmonary tuberculosis disease.

Search …

Proteomic-Based Stemness Score Measures Oncogenic Dedifferentiation And Enables The Identification Of Druggable Targets, Iga Kołodziejczak-Guglas, Renan L S Simões, Emerson De Souza Santos, Elizabeth G Demicco, Rossana N Lazcano Segura, Weiping Ma, Pei Wang, Yifat Geffen, Erik Storrs, Francesca Petralia, Antonio Colaprico, Felipe Da Veiga Leprevost, Pietro Pugliese, Michele Ceccarelli, Houtan Noushmehr, Alexey I Nesvizhskii, Bożena Kamińska, Waldemar Priebe, Jan Lubiński, Bing Zhang, Alexander J Lazar, Paweł Kurzawa, Mehdi Mesri, Ana I Robles, Clinical Proteomic Tumor Analysis Consortium, Li Ding, Tathiane M Malta, Maciej Wiznerowicz

Faculty, Staff and Student Publications

Cancer progression and therapeutic resistance are closely linked to a stemness phenotype. Here, we introduce a protein-expression-based stemness index (PROTsi) to evaluate oncogenic dedifferentiation in relation to histopathology, molecular features, and clinical outcomes. Utilizing datasets from the Clinical Proteomic Tumor Analysis Consortium across 11 tumor types, we validate PROTsi's effectiveness in accurately quantifying stem-like features. Through integration of PROTsi with multi-omics, including protein post-translational modifications, we identify molecular features associated with stemness and proteins that act as active nodes within transcriptional networks, driving tumor aggressiveness. Proteins highly correlated with stemness were identified as potential drug targets, both shared and tumor …

Nurturing Belonging: A Qualitative Study Of Participation In A Gardening Group For People Living With And Beyond Cancer, Melissa Jacobs, Kerryann Steele, Alison Warren

School of Health Professions

PurposeThe incidence of cancer is increasing globally and engagement in meaningful occupations is fundamental for people living with and beyond cancer. There is a growing body of evidence regarding the health and well-being benefits of engaging in nature-based occupations, however, there is limited evidence specific to this population. This study aims to explore the experiences of engaging in Blooming Well, a gardening group created to provide opportunities for people recovering from or living with cancer.Design/methodology/approachA qualitative case study methodology was used to explore perspectives of both group leaders and participants of the Blooming Well group. Study participants included two group …

Role Of Glucuronoxylomannan And Steryl Glucosides In Protecting Against Cryptococcosis, Gabriel Soares Matos, Tamara L Doering, Et Al.

2020-Current year OA Pubs

The development of vaccines for fungal diseases, including cryptococcosis, is an emergent line of research and development. In previous studies, we showed that a

Effect Of Post-Operative Clothing, Bandage, And Collar Application On Stress After Ovariohysterectomy In Cats, Çağatay Esin, Seba Raouf, Gülşah Saral, Büşra Uzun

The Thai Journal of Veterinary Medicine

Ovariohysterectomy is a common surgical procedure in veterinary medicine, not only for reproductive control but also for conditions like pyometra, metritis, mammary tumors, and other reproductive disorders. Pain in cats occurs as a response of the body and is accompanied by various physiological and behavioral changes. Pain in cats, though prevalent, is often under-recognized and inadequately treated. The Glasgow pain scale is a psychometrically designed tool for assessing acute pain in veterinary patients. Serotonin (5-HT), a biogenic monoamine derived from tryptophan, functions as a mood-regulating neurotransmitter and may decrease following surgical interventions. This study aimed to evaluate post-operative pain and …

This Is Theatre: Deconstructed Repetition And Theatre-In-Education During Covid-19, Subbah Mir

Spect-actor: A Journal of Pedagogy & Theatre of the Oppressed

This project report is a practical application of deconstructed repetition model, I devised by merging Augusto Boal and Baz Kershaw, in an undergraduate Composition Writing class in Louisiana State University, Baton Rouge, U.S. As the facilitator Deconstructed repetition means cost-effective repetition of personal and local stories for introspection in order to engage the community members, address the oppression, and celebrate the local culture. The four stipulations of the models are: avoiding the Western canon (or hegemonic voice), making the audience(s) see direct and indirect oppression, circumventing commodification while maintaining audience interest, and celebrating local culture instead of downright criticizing it. …

Isto É Teatro: Repetição Desconstruída E Teatro Na Educação Durante A Covid-19, Subbah Mir

Spect-actor: A Journal of Pedagogy & Theatre of the Oppressed

Neste artigo, discuto o uso do círculo de narrativas (Roadside Theatre, 1999) denominado como um "modelo de repetição desconstruída" para o ativismo comunitário, capaz de conectar os problemas pessoais dos alunos com as questões sociais/comunitárias. Iniciei este projeto com um curso síncrono online de Redação de Textos para alunos de graduação. Ao final do semestre, os alunos participaram dinamicamente do ativismo comunitário por meio da exploração de questões socio-pessoais, o que levou a diversas iniciativas empreendidas posteriormente pelo Grêmio Estudantil da universidade. Este projeto foi conduzido para testar o Modelo de Repetição Desconstruída desenvolvido como uma ferramenta eficaz de ativismo …

What's So Funny About Theatre Of The Oppressed?, Jennifer Schaupp

Spect-actor: A Journal of Pedagogy & Theatre of the Oppressed

This article examines my 2023 Pedagogy and Theatre of the Oppressed Conference virtual workshop within the framework of comedy and embodiment. It considers the activities I facilitated and their origins along with my perception of participant reaction for other educators and facilitators to adapt for their own educational experiences.

Enraizados No Amor E Na Solidariedade: Acampamentos Estudantis Por Uma Universidade Popular, Robin Brandehoff

Spect-actor: A Journal of Pedagogy & Theatre of the Oppressed

No semestre acadêmico do outono de 2023, universidades em todo o país testemunharam uma onda de acampamentos estudantis pedindo o cancelamento de verbas universitárias a Israel e suas operações militares (Reeve, 2023). Esses acampamentos incitaram prisões de estudantes, professores e membros da comunidade acadêmica; brigas violentas entre manifestantes e contramanifestantes mascarados; e cancelamentos de formaturas universitárias para a geração da COVID-19 que também não conseguiu vivenciar a formatura do ensino médio. No entanto, esses acampamentos também criaram aulas no campus, oportunidades para alunos e administradores aprenderem uns com os outros e para a construção de comunidades no campus que se …

Rooted In Love And Solidarity: Student Encampments For A Popular University, Robin Brandehoff

Spect-actor: A Journal of Pedagogy & Theatre of the Oppressed

In the spring academic semester of 2024, universities across the nation saw an uptick of student encampments asking for a divestment of university funds from Israel and its military operations (Reeve, 2023). These encampments have incited arrests of students, faculty, and community members; violent brawls between protesters and masked counter-protesters; cancellations of university graduations for the COVID-19 generation who did not get to experience their high school graduation either—and yet these encampments have also created on-campus teach-ins, opportunities for students and administrators to learn from another, and for the building of campus communities which extend beyond the classroom and school-sanctioned …

People Powered Legislative Theatre Playbook: The Dream, The Journey, The Resource, Oluchi Igili, Katy Rubin

Spect-actor: A Journal of Pedagogy & Theatre of the Oppressed

No abstract provided.

Book Review Of The Squad By Christina Soontornvat And Joanna Cacao, Simon Boonsripaisal

Journal of Southeast Asian American Education and Advancement

The Squad by Christina Soontornvat and illustrator Joanna Cacao is a follow-up to the indie bestseller The Tryout (2022). The graphic memoir is written for educators, parents, and students in K-12. The illustrations are beautifully drawn, the dialogue is humorous, and the facial expressions describe how the characters are feeling. The main character, Christina, is now an 8^th grader in Texas. Set in the 1990s and the cover page shows her friends lifting her up as she strikes a cheerleading pose. Christina tries out for cheer again, encounter’s identity conflict, and grapples with her parents’ divorce. This review discusses …

Lincoln's Greatest Work Brochure

Eartha M. M. White Textual Material

Brochure: Lincoln's Greatest Work. Contains an appeal for Mercy Hospital in Philadelphia, Pennsylvania. Undated.

Environmental Migration And Governance Deficiencies - A Topic Worth Attention, Dr. Friedarike Santner

Future Journal of Social Science

No abstract provided.

Technology In International Relations: A Theoretical Perspective On Understanding Us-Chinese Tech War, Ahmed Elbassoussy

Future Journal of Social Science

The massive technological boom that the international scene has witnessed recently has contributed to rearranging the structure of the international system, as the importance of the technological factor in the equation of the relative power of the state has increased. This has led to an increase in the intensity of competition between the major international powers, especially between the United States and China, which has prompted many analysts to restore the concept of the US-China technological war, or what Known as “Cold War 2.0). In this context, this paper seeks to develop a comprehensive framework that combines the theoretical and …

Relationship Between Governments Spending On Education Sector And Economic Growth In Tanzania, James Daniel Chindengwike

Future Journal of Social Science

Investment of education for every government are very critical to promote economic growth for both reached and emerging countries. The study aimed to assess the relationship between government spending on education and Tanzanian economic growth from 1990 to 2024. The study used a time series research design (longitudinal data) using a quantitative technique. The research employed documentary review to collect secondary data from 1990-2024 (34 Observations). The data were analysed inferentially and descriptively statistics. The study indicated that government spending in education had a positive and statistically significant impact on short-term economic growth but no relevant impact in the long …

Awareness And Change In Socrates Political Thought, Mohamed Talaat

Future Journal of Social Science

The research paper explores the importance of public political awareness in Socratic philosophy in relation to societal and political changes that can happen as a consequence. By seeing how Socrates emphasized moral integrity, critical thinking, and pursuit of knowledge in order to achieve virtue. The research tests the hypothesis that an increased level of awareness can lead to a societal and political transformation. The research tackles some questions, such as the steps needed for a political change, the tools to increase awareness, and the role of philosophers and great thinkers in guiding their societies to such a path. Through analyzing …

Options For Modifying The Patient Protection & Affordable Care Act In The United States: An Equitable Perspective, Dr. Amira Elshamy

Future Journal of Social Science

The Patient Protection & Affordable Care Act referred to as Affordable Care Act (ACA), is a United States (U.S.) federal statute, signed into law by former President Barack Obama in 2010, it is also known as Obamacare. The law has made health insurance more accessible and affordable for millions of Americans, yet many still remain uninsured or struggle with unaffordable coverage. In addition, the Centers for Medicare and Medicaid Services started receiving a significant increase in complaints from consumers who reported being enrolled in Marketplace coverage without their consent, around 5 million people were wrongly enrolled in subsidized ACA coverage …

Roles Of Nigerian Ulama In Politics And Nation-Building: The Controversy, Achievements And Recommendations, Abdulkadir Salaudeen, Saidu Ahmad Dukawa

Future Journal of Social Science

Religion and politics in Islam are not watertight compartments. In Islam, it is impossible to separate the state from religion because Islam is a state in the political sense and a religion in the spiritual sense. It is true that state-religion-separation is the norm in the secularist West. It is not true in Islam where state and Islam are indivisibly connected. Despite the interconnectedness between Islam and politics, a lot of people see participation of ulama in politics as an abomination due to the current of apolitical Islam that is sweeping across the circle of ulama. Focusing on Nigeria, this …

Evaluating The Use Of Repetitive Transcranial Magnetic Stimulation In A Patient With Treatment Resistant Depression, Autism Spectrum Disorder, And Post-Traumatic Stress Disorder: A Case Report, Luke Fritsch Ba, Mba, Msiv, Oluwafunke O. Ogunremi Bs, Msiv, Alexandra R. Job Bs, Msiv, James Hellekson Md

Aesculapius Journal (Health Sciences & Medicine)

Despite a wide array of therapeutic modalities, many patients with Major Depressive Disorder (MDD) experience no significant improvement in symptoms with traditional treatment. Given the prevalence of Treatment Resistant Depression (TRD), other alternative therapeutic modalities for MDD are being researched. Repetitive Transcranial Magnetic Stimulation (rTMS) is one modality that continues to show successful therapeutic outcomes for those with TRD. The aim of this study is to highlight a case of rTMS being used on a patient with TRD, autism spectrum disorder (ASD), post-traumatic stress disorder (PTSD), and substance use.

Methods:

Our patient is a 53-year-old female who first presented to …

Orca Annual Report 2024-25, Msu Orca

Steeplechase: An ORCA Student Journal

Quick Facts about ORCA in Academic Year 2024-25

• 12 slots filled for Posters-at-the-Capitol
• 346+ students presented at Scholars Weeks with support from 110+ faculty members
• 28 grants awarded totalling over $23,000
• Dr. Kelly Taylor named University Distinguished Mentor 2025

Shrink: Story Of A Fat Girl [Book Review], Jj Pionke

Disability in LIS (DisLIS)

Shrink is a graphic memoir and graphic medicine title that chronicles one woman's journey with her fat body. Along the way, she educates the reader about the politics, history, health, medicine, and perspectives of fatness.