Digital Commons Network^™

Type I Interferon Protects Against Bone Loss In Periodontitis By Mitigating An Interleukin (Il)-17-Neutrophil Axis, Jinmei Zhang, Qiong Ding, Angela X Wang, Maoxuan Lin, Ning Yu, Kevin Moss, Megumi A Williamson, Di Miao, Julie T Marchesan, Erliang Zeng, Wei Shi, Hongli Sun, Yu Leo Lei, Shaoping Zhang

Faculty, Staff and Student Publications

Type I interferons (IFNs-I), a group of pleiotropic cytokines, critically modulate host response in various inflammatory diseases. However, the role of the IFN-I pathway in periodontitis remains largely unknown. In this report, we describe that the IFN-β levels in the gingival crevicular fluid of human subjects were negatively associated with periodontitis and clinical gingival inflammation. Disruption of IFN-I signaling worsened alveolar bone resorption in a ligature-induced periodontitis murine model. Deficiency of the IFN-I pathway resulted in an exaggerated inflammatory response in myeloid cells and drastically increased the interleukin-17 (IL-17)-mediated neutrophil recruitment in the gingiva. We further identified that the myeloid …

The Impact Of Type 2 Diabetes Mellitus On The Severity Of Alzheimer's Disease In Hispanic Populations In The Rio Grande Valley: A Pilot Retrospective Chart Review, Maria Camila Gonzalez Tovar, Daniel Salinas, Kelsey Baker

School of Medicine Publications

Background: Alzheimer's disease (AD) is becoming more prevalent worldwide, leading to a growing demand to understand the impact of risk factors on disease progression. Notably, type 2 diabetes mellitus (DM) has emerged as a significant risk factor for the development of AD, given the pathophysiological role of insulin resistance in cognitive impairment. In particular, the impact of type 2 DM on AD development and severity may be heightened in Hispanic populations due to the high prevalence of both conditions in this community. Here, we sought to understand the role of type 2 DM in AD severity in a Hispanic population …

Management And Optimization Of Chronic Renal Insufficiency In The Setting Of Kidney Cancer A Systematic Review, Jessica K. Cobb, Hiroko Miyagi, Jad Chahoud, Claude Bassil, Philippe E. Spiess

Division of Internal Medicine Faculty Papers & Presentations

PURPOSE: There is a bidirectional relationship between chronic kidney disease and the incidence of renal cell carcinoma. Despite the frequency of patients with both chronic kidney disease and renal cell carcinoma, there are limited systematic reviews detailing the nuanced treatment. This review provides comprehensive insights for clinicians for managing chronic kidney disease, and renal cell carcinoma. Methods and Methods: We reviewed published literature that examined either chronic kidney disease and renal cell carcinoma or an indirect contributor of both.

RESULTS: We compare and contrast renal cell carcinoma treatment with partial and radical nephrectomies, ablative techniques, and radiation and their impact …

So Who Gets To Be Modern? Jadidism And Reform In Late Nineteenth And Early Twentieth Century Russia, Grant Douglas Linville

University Honors Theses

Jadidism was a sociocultural reformist project from the 1880s to 1920s developed by Muslim intellectuals in the Russian Empire and the Soviet Union. The Jadidist movement derives its name from the "new-method" (usul-al Jadid) schools that spread Jadid pedagogy, which revolved around the inclusion of secular topics and Western knowledge as well as instruction in local, Tatar, and Russian languages, in addition to the already present religious studies accompanied by Arabic and Persian taught in the Islamic educational institutions the maktab and madrasa (primary and higher education respectively). Over time Jadidism grew to encompass a host of societal …

The Potential For Improv As A Therapeutic Tool In The Context Of Dialectical Behavior Therapy: Suggestions For Dbt Clinicians, Jocelyn Borden

University Honors Theses

This thesis explores the theoretical and practical intersections between improvisational theater and Dialectical Behavior Therapy (DBT), proposing that the core tenets of improv closely align with the philosophical foundation and therapeutic goals of DBT. Aimed at mental health professionals, this work provides a conceptual framework and praxis for incorporating improv-based activities into DBT skills training to enhance client engagement, experiential learning, and emotional resilience. Through an examination of improv theory, parallels with DBT principles, and practical suggestions for integration, the thesis outlines how applied improvisation can be used as a supplemental tool in traditional DBT treatment. The final section includes …

Beyond Capitalist Realism: Indigenous Worldviews As Critique And Alternative, Celine Jessup

University Honors Theses

This paper engages Mark Fisher's Capitalist Realism: Is There No Alternative? as a foundational critique of late capitalism's ideological dominance, and proposes Indigenous worldviews as both a critical lens and a generative alternative. Fisher defines capitalist realism as a pervasive structure that colonizes imagination, depoliticizes systemic crises, and renders other ways of living unthinkable. He illustrates how capitalism commodifies resistance, pathologizes dissent, and obscures accountability, particularly through institutions like the call center and discourses on mental health and climate change. In contrast, the paper turns to Indigenous political theories—drawing on thinkers such as Kim TallBear, Daniel Heath Justice, Ocean Ripeka …

How Do Montessori-Based Activities Affect Behaviors For Older People With Dementia: A Literature Review, Isabel Quigley

University Honors Theses

Objectives: This literature review is meant to analyze the development on the research on Montessori-based activities for adults with dementia.

Introduction: Baby Boomers are the largest generation to enter senior age (65+) in history due to the advancement in medicine to increase life expectancy. Dementia is a neurocognitive disease that affects parts of the brain related to memory and signs typically surface around 65 years old. Dementia is not considered healthy aging. Montessori-based activities have been recently developed as an intervention to encourage a feeling of accomplishment and success for adults with dementia.

Methods: Two electronic databases …

Testing Their Limits: Impact And Intentions Of Standardized Testing In K-12 Schools, Grace O. Herd

University Honors Theses

The integration of High-Stakes standardized testing into U.S. public education to serve as an accountability system has been a disputed issue since the No Child Left Behind Act (NCLB) mandated these assessments nationwide in 2002. NCLB aimed to locate and identify schools failing to reach Adequate Yearly Progress (AYP) and trigger a chain of interventions based on student performance, as an effort to track measurable outcomes from federal education funding. While supporters view these standardized tests as quantifiable data for school effectiveness in academics, critics challenge the claim of validity.

This review integrates current psychological research in the area of …

At Home In Horror: Women And Body Horror, Brooklynn Kreps

University Honors Theses

While most discussion around the subgenre of body horror focuses on its birthplace of film, the richest iterations come from women writing body horror fiction to explain the experience of womanhood. As body horror focuses on fear of painful or absurd mishap with the body. Women experience pain or absurdity in their own bodies every day with processes like menstruation, pregnancy, puberty, and heightened chances of becoming a victim of sexual assault. Furthermore, women experience society's forceful shaming and fear about natural processes of the body and experiences such as anger and sexual desire. Using this idea as a framework, …

Development Of Preventive Dental Guidelines In The Primary Healthcare Setting In Egypt: A Delphi Method, Basant Mehriz

Theses and Dissertations

This study addresses the critical need for standardized preventive dental care guidelines within Egypt's primary healthcare system amid the rising burden of oral diseases. Through a systematic two-phase methodology combining a comprehensive literature review and a Delphi consensus-building process engaging 35 dental professionals, the research established priorities for contextually appropriate preventive measures. The consensus framework revealed strong support for clinical interventions (mean of 83% agreement), particularly fluoride-based prevention; community initiatives (mean of 83%), especially school-based programs; policy measures (mean of 77%) such as workforce and educational development, though with variable support for taxation and social determinants approaches. Statistical analysis demonstrated …

An Llm Approach For Automating The Analysis Of Bim (Ifc) Data, Miral Selim

Theses and Dissertations

This thesis introduces a novel methodology for automating the analysis of Building Information Modeling (BIM) data using LangGraph, an advanced extension of the LangChain framework, and integrating Google’s Gemini Large Language Model (LLM) with IfcOpenShell. BIM, and specifically Industry Foundation Class (IFC) files, are widely used in the construction industry for representing and managing building data. However, analyzing this data effectively remains a significant challenge due to its volume and complexity. Additionally, analyzing BIM data typically requires knowledge of different BIM software depending on the application. This research addresses this challenge by creating a workflow that utilizes LangGraph’s ability to …

Removal Of Fluoroquinolones From Water Systems Employing Rice Husk Composited Sponges Via Nanoadsorption, Dalia Kanaa

Theses and Dissertations

A novel nanocomposite of polyvinyl alcohol formaldehyde (PVF) sponge loaded with green zinc oxide nanoparticles (ZnONP) and referred to as (NP-PVF) was fabricated as a potential adsorbent of ciprofloxacin from water. A simple mechanical foaming process was used to synthesize the adsorbent. Rice husk extract was used to synthesize zinc oxide nanoparticles (ZnONP) for its phytochemicals as reducing agents. A facile and low-energy-dependent extraction method was used that did not require the use of high-temperature annealing. The synthesized nanoparticles showed a maximum UV absorption at 347 nm, which corresponds to a 3.58 eV band gap energy. FTIR confirmed the successful …

The Dubr/Mir-210-5p/Retsat Axis In Cholesterol-Associated Steatohepatitis: Clinical Signatures And Molecular Mechanisms, Hana Mahmoud Abdelzaher

Theses and Dissertations

Metabolic-associated fatty liver disease (MAFLD) represents an increasing global health challenge, with cholesterol-associated steatohepatitis (CASH) emerging as a distinct pathological entity warranting investigation. While CASH demonstrates unique features compared to traditional triglyceride-driven steatohepatitis, its underlying molecular mechanisms remain poorly understood. This study investigates a novel regulatory axis involving DPPA2 Upstream Binding RNA (DUBR), miR-210-5p, and retinol saturase (RETSAT). 170 patient samples revealed progressive axis dysregulation in disease states, with RETSAT emerging as a highly accurate diagnostic marker (AUC=1.000). Using novel in vitro models of MASH and CASH, we demonstrated that miR-210-5p modulation significantly affects lipid accumulation and cellular phenotype, with …

The Structure Of The Drp1 Lattice On Membrane, Kristy Rochon, Anelise N. Hutson, Jason A. Mears

Faculty Scholarship

Mitochondrial health relies on the membrane fission mediated by dynamin-related protein 1 (Drp1). Previous structural studies of Drp1 on remodeled membranes were hampered by heterogeneity, leaving a critical gap in the understanding of the mitochondrial fission mechanisms. Here we present a cryo-electron microscopy structure of full-length human Drp1 decorated on membrane tubules. Using the reconstruction of average subtracted tubular regions (RASTR) technique, we report that Drp1 forms a locally ordered lattice along the tubule without global helical symmetry. The filaments in the lattice are similar to dynamin rungs with conserved stalk interactions. Adjacent filaments are connected by GTPase domain interactions …

Assessing The Impact Of Spraying An E. Faecium Probiotic At Hatch And Supplementing Feed With A Triple-Strain Bacillus-Based Additive On Bco Lameness Incidence In Broiler Chickens, Khawla Alharbi, Anh Dang Trieu Do, Abdulaziz Alqahtani, Ruvindu Perera, Alexa Thomas, Antoine Meuter, Adnan Ali Khalaf

Poultry Science Faculty Publications and Presentations

Bacterial chondronecrosis with osteomyelitis (BCO) is a major cause of lameness in broiler chickens. This condition arises when bacteria from the gastrointestinal or aerosol tract migrate to infect bone microfractures, often exacerbated by rapid growth, reduced blood flow, and mechanical stress. As concerns about antibiotic resistance grow, probiotics have gained attention for their potential to improve gut health and reduce systemic bacterial load. This study evaluated the efficacy of a probiotic program comprising an Enterococcus faecium-based spray (2 x 10(9) CFU/bird at hatch) and a triple-strain Bacillus-based feed additive (B. subtilis 597, B. subtilis 600, and B. amyloliquefaciens 516 at …

Asymmetric Cingulum Bundle Connectivity Is Modulated By Paracingulate Sulcus Morphology, Isabel A Danstrom, Joshua A Adkinson, Meghan E Robinson, Lu Lin, Atul Maheshwari, Ben Shofty, Garrett Banks, Mohammed Hasen, Sameer A Sheth, Alica M Goldman, Eleonora Bartoli, Sarah R Heilbronner, Kelly R Bijanki

Faculty, Staff and Students Publications

The cingulum bundle (CB) is a group of axons supporting connectivity among several functional brain networks relevant in healthy and diseased states. The paracingulate sulcus (PCS) is present in at least one cerebral hemisphere across 70% of the population. PCS presence versus absence is linked to differences in structure and function of the anterior cingulate cortex, though the influence of PCS on the white matter of the CB remains unknown. The objective of this work was to define the CB electrographic connectivity profile and determine the impact of PCS morphology on CB engagement. Single-pulse electrical stimulation in combination with stereo-electroencephalography …

Transgenerational Obesity Modulation Of Gut Mucosal Immunity, Chen-Ting Hung, Justin Kern, Tihana Trsan, Santosh K Panda, Marie Laury, Umang Jain, Marco Colonna, Thaddeus S Stappenbeck, Ta-Chiang Liu

2020-Current year OA Pubs

The prevalence of obesity in the United States has continued to increase over the past several decades. A growing concern is that transgenerational effects of obesity negatively impact physiologic functions. We showed that consumption of a high fat, high sugar "Western" diet (WD) decreased the density of both gut innate (Paneth cells) and adaptive immune cells (intraepithelial lymphocytes; IEL). We asked whether consumption of WD impacts gut mucosal immunity in the offspring. WD-mediated Paneth cell loss was reversible, whereas IEL loss was not. However, the overall composition of the fecal microbiome and response to infection were defined by the diet …

Confronting The Injustices That Prevail From Revealing Americans’ Most Private Information: Their Genetic Code, Aubrey Fleming

Penn State Journal of Law & International Affairs (2012 - Present)

No abstract provided.

Cuba And The Constitution Of A Stable State Of Misery: Ideology, Economic Policy, And Popular Discipline, Larry Catá Backer

Penn State Journal of Law & International Affairs (2012 - Present)

No abstract provided.

Foreword, Alison M. Whelan

Georgia State University Law Review

No abstract provided.

Faculty Masthead, Georgia State University College Of Law

Georgia State University Law Review

No abstract provided.

The Nightly Curse, Thomas Cohen

Night Flight: Online Literary Journal

The Nightly Curse is a fantasy fiction following the life of Theodore Silas, who is torn between two worlds each night he falls asleep and each morning he awakens. At night, he believes that he is Elias Softstar Crystalfire, the hero of Dragon Fawn on a quest to save the realm but, at day, he is Theodore Silas. He can't tell the difference between the worlds he lives during the night and day and can't come to terms that his real identity Theodore.

Enhancing Cybersecurity Based On Blockchain Technology: A Systematic Review, Sarah Mohammed Shareef, Rehab Flaih Hassan

Journal of Soft Computing and Computer Applications

Cybersecurity is a crucial component of the security system that guards against unauthorized access to digital transactions. Blockchain is a decentralized ledger used to securely exchange digital currencies and conduct trades and transactions. Blockchain technology has led to significant changes in electronic transactions. The enormous potential is being exploited in many areas such as financial services, real estate, supply chain, and the Internet of Things. Despite being a security system, it has suffered from security threats to sensitive data. Phishing and 51% attacks can circumvent blockchain security, highlighting the need for thorough user education and awareness. Additionally, blockchains based on …

Economic Warfare Against Iran’S Nuclear Program, Zoey E. Weiss

Undergraduate Theses, Capstones, and Recitals

This study evaluates the effectiveness of economic sanctions imposed on Iran’s nuclear ambitions, with a particular emphasis on the Joint Comprehensive Plan of Action (JCPOA) and the Maximum Pressure Campaign (MPC). Using the Economic Coercion Trilemma framework, this research analyzes the impact of these sanctions regimes on Iran’s nuclear program through the lenses of efficacy, political feasibility, and unintended consequences. Ultimately this study explores the question: Could sustained sanctions have constrained Iran’s access to critical resources, effectively halting its pursuit of nuclear weapons? The findings suggest that while both the JCPOA and MPC had varying degrees of success, neither fully …

Cunning Commies, Dumb Democrats, And Exiled Germans: A Holistic Postmortem Of The 1948 Czechoslovak Coup D'État, Douglas Joys

Undergraduate Theses, Capstones, and Recitals

The role played by the post-WWII expulsion of ethnic Germans from Czechoslovakia in catalyzing the 1948 Czechoslovak coup d'état has been underexplored in favor of the traditional narrative of an East-West clash between Czechoslovak democratic and communist parties backed by the United States and Soviet Union, respectively. Scholarship on the expulsion and the coup has on occasion brought up connections between the two events, albeit briefly and only as a small part of larger examinations of one of the two. The Eastern and Western forces at play in Czechoslovakia were undoubtedly key factors in the coup’s outcome: the end of …

Elemental Analysis Of Sediments In Johnson County, Kansas: Applications In Fluvial Suspended Sediment Tracing, Kiena Campbell

Undergraduate Theses, Capstones, and Recitals

This exploratory study investigates whether bulk elemental analysis of sediment samples using inductively coupled mass spectrometry (ICP-MS) can reveal chemical signatures that identify anthropogenic contributions to sedimentation and increased fluvial suspended sediment loads, and whether these contribution sources can be identified. Human activity, urbanization, and changes in land use increase erosion, resulting in higher-than-natural suspended sediments (SS) in waterways and increasing sedimentation in reservoirs across the state of Kansas. These threats to freshwater storage capacity are especially urgent given the projected rise in freshwater demand in the Great Plains region driven by climate change. Understanding the origin of anthropogenic SS …

Transitional Justice: Understanding The Impact Of The Initiatives In Bosnia-Herzegovina And Guatemala, Rachel Bienstock

Undergraduate Theses, Capstones, and Recitals

This thesis examines the impact of transitional justice initiatives on reconciliation and healing in regions that have experienced mass atrocities, with a focus on Guatemala and Bosnia and Herzegovina (BiH). While transitional justice processes aim to address the legacies of human rights violations and foster sustainable peace, their impact varies significantly depending on the context and the mechanisms employed. By analyzing existing scholarship and using a case study methodology to gather in-depth data about each instance, this research explores how different approaches to transitional justice can serve a diverse group of communities and how different factors contribute to their success. …

Multidrug Resistance: Are We Still Afraid Of The Big Bad Wolf, Abdulelah Alhazza, Adenike Oyegbesan, Emira Bousoik, Hamidreza Montazeri Aliabadi

Pharmacy Faculty Articles and Research

After the era of multidrug resistance (MDR) against cytotoxic chemotherapy, the development of resistance against newly developed molecularly targeted drugs also seems inevitable. While the mechanisms involved in resistance against these two categories of anticancer drugs are different, the principles are similar: inherent resistance (also known as primary resistance) is a result of heterogeneity in cancer cells where a subpopulation of the cells do not show a favorable initial response to the drug, while acquired resistance (or secondary resistance), as the name suggests, is developed after repeated treatments due to the plasticity of cancer cells. Despite the introduction of a …

Storytelling In Reappraisal: How Narratives Can Change Emotion, Makabe Aberle

Undergraduate Theses, Capstones, and Recitals

Emotion regulation strategies, including cognitive reappraisal, are essential for maintaining psychological well-being. While prior work has demonstrated the effectiveness of reappraisal and begun to dig into different specific aspects such as the goals and structure of reappraisals, little is known about how the narrative quality of generated reappraisals impacts their success. The present, preregistered study investigated whether the quality of reappraisal narratives is associated with decreases in negative emotion following reappraisal. Participants across two studies (N = 342) wrote about a recent stressor and then reappraised the event by writing a redemption narrative. Narratives were rated for qualities such as …

Sex And Control In Redeemer Georgia, Anthony Michael Kreis

Georgia State University Law Review

This Essay explores the interplay of history, law, and morality behind the first abortion law in Georgia. Examining the philosophical underpinnings of liberty and equality as articulated in Georgia’s constitutional history through time, this Essay highlights the moral contradictions inherent in the legal frameworks of Reconstruction Georgia. The origin of Georgia’s 1876 abortion law contains multitudes—rooted in race-based contestations for political power, the sociological evolution of medical practice, and evolving attitudes on individual rights. At times, White elites used abortion to attack Yankee culture and stir up racist fears about moral contagion associated with Radical Republicans. To this end, when …