Digital Commons Network^™

Molecular Mechanisms Of L-Type Calcium Channel Dysregulation In Heart Failure, Arbab Khalid, Abu-Bakr Ahmed, Randeep Gill, Taha Shaikh, Joshua Khorsandi, Ali Kia

Department of Internal Medicine Faculty Research

The L-type calcium channels (LTCCs) function as the main entry points that convert myocyte membrane depolarization into calcium transients, which drive every heartbeat. There is increasing evidence to show that maladaptive remodeling of these channels is the cause of heart failure with reduced ejection fraction (HFrEF) and heart failure with preserved ejection fraction (HFpEF). Recent experimental, translational, and clinical studies have improved our understanding of the roles LTCC expression, micro-domain trafficking, and post-translational control have in disrupting excitation–contraction coupling, provoking arrhythmias, and shaping phenotype specific hemodynamic compromise. We performed a systematic search of the PubMed and Google Scholar databases (2015–2025, …

Game, Set, Empower: A Comparative Instagram Analysis Of Branding And Engagement In The Confederation Of African Football (Caf) Women’S And Men’S Champions League, Nour Abdelkader Ms

Theses and Dissertations

The rise of women’s football has placed new emphasis on digital branding, with social media becoming a vital space for visibility, engagement, and representation. This thesis investigates how Instagram content strategies influence fan engagement during the CAF Women’s and Men’s Champions League tournaments. Specifically, it examines the role of content type (match, behind-the-scenes, off-the-pitch, promotional), marketing orientation (organic, sponsored, collaborative), and post format (reel, carousel, photo, graphic) in shaping audience interaction.

Using an explanatory sequential mixed methods approach, the study analyzed 674 Instagram posts (276 CAFWCL, 398 CAFCL) and conducted semi-structured interviews with five digital sports professionals, including CAF digital …

Continuum Of Academic Collaboration: Issues Of Inconsistent Terminology In Multilingual Context, Cristo Leon Ph.D., James Lipuma Ph.D., Marcos O. Cabobianco, Maria B. Daizo

STEM for Success Resources

Journal of Systemics, Cybernetics and Informatics
1690-4524 (Online)

Late Holocene To Modern Dust Increases In Antarctic Ice Cores, Lillian D. Tipton

Dartmouth College Master’s Theses

Dust aerosols impact global climate by influencing direct and indirect radiative forcing, serving as cloud condensation nuclei, and supplying trace nutrients to the ocean that affect the marine biological pump. Antarctic ice core dust records show dust deposition changing in step with global climate over the past eight ice-age cycles. However, fewer studies have focused on Antarctic dust deposition during the late Holocene-to-modern period. Notably, 20^th-century increases in dust deposition have been observed in ice cores from James Ross Island (JRI) and Dronning Maud Land, with the JRI record hypothesized to reflect desertification and land-use changes in Patagonia. …

The Correlation Of Trauma-Informed Classrooms Without Support Infrastructure And Teacher Burnout, Sunshine O'Connor

University Honors Theses

This thesis examines the impact of Trauma-Informed Care (TIC) implementation in classrooms on teacher burnout, specifically focusing on settings with insufficient support infrastructure. While TIC is recognized as beneficial for all students, not just students affected by trauma, a synthesis of scholarly literature highlights the significant challenges faced by educators when proper resources, training, and institutional backing are lacking. Existing research indicates that teachers implementing TIC in inadequately supported environments report higher levels of emotional exhaustion, depersonalization, and overall burnout. These challenges appear most acute for teachers in schools with limited professional development, insufficient mental health resources, and weak administrative …

Virtual Versus In-Person Rose Program (La Luz) As Universal Prevention For Perinatal Depression: Protocol For A Randomized Controlled Trial In A Safety Net Hospital, Daphne Y. Liu, Nicholas S. Perry, Catherine H. Demers, Jennifer S. Hyer, Anely Alamo, Paige Vuksanovich, Nandi Dube, Erin R. Flanagan, Robert J. Gallop, Galena K. Rhoades, Elysia Poggi Davis

Psychology: Faculty Scholarship

Perinatal depression disproportionally affects underserved communities, who need effective and accessible prevention programs. Reach Out, Stay strong, Essentials for new mothers (ROSE) has demonstrated effectiveness in preventing postpartum depression in underserved populations when delivered in person. This ongoing randomized controlled trial (RCT) tests the novel virtual implementation of ROSE as universal prevention in a Federally Qualified Health Center setting. We adopted the name, La Luz, for ROSE to be culturally relevant to our population. Pregnant individuals < 30 gestational weeks (target N = 900) are randomized to either the virtual or in-person La Luz program, which consists of four 90-min group sessions. Groups are offered in English and Spanish, based on participants' preference. Participants complete surveys at seven timepoints: before program, 28 gestational weeks, 35 gestational weeks, and 6-weeks, 3-months, 6-months, and 12-months postpartum. Primary outcomes are postpartum depression severity measured by the 20-item Symptom Checklist (SCL-20) and 10-item Center of Epidemiologic Studies Depression Scale (CESD-10). We will perform intent-to-treat analysis to test whether virtual La Luz is non-inferior to in-person La Luz. This study also evaluates implementation process and outcomes of both modalities of La Luz to inform the development of an implementation toolkit. This RCT contributes to our knowledge of perinatal depression prevention and addresses access barriers for underserved populations. If effectiveness of virtual La Luz is demonstrated, the new evidence for a scalable low-cost prevention can be used to reduce perinatal depression and offer accessible treatment options for people who face significant barriers to care.

Design And Evaluation Of An Innovative Biomimetic Coral Transport Container, John-Christopher L. Calulo, Wilfredo Y. Licuanan, Leah D. Madrazo, Dana Isabelle P. Villano, Angel Nicole B. Villanueva

Sinaya: A Philippine Journal for Senior High School Teachers and Students

Coral reefs are vulnerable to disruptive human activities such as pollution, overfishing, and coastal development—degrading water quality and reef structures. Active reef restoration entails temporarily relocating several corals to aquaculture facilities to achieve successful rehabilitation; however, current coral transport methods pose certain risks, such as stress-induced mortality, which can result from physical damage during transportation. Existing studies on coral transport have explored various techniques for collecting, shipping, and maintaining live coral specimens. The design consists of petal-shaped areas where the waves gather, akin to a coral reef’s grooves, separated by wedges—the spurs—that cause waves to divide. The different design modifications …

Investigating The Properties Of Eco-Bricks Composed Of Sawdust, Bamboo, And Varying Composition Of Sugarcane Bagasse Ash And Portland Cement, Wilfred Victor C. Marasigan, Julia Sophia Antonia S. Encarnacion, Czyrus Michael A. Bajeta, Alijah F. Gonzales, Juan Carlo T. Gumangan

Sinaya: A Philippine Journal for Senior High School Teachers and Students

With the construction industry contributing nearly 40% of global greenhouse gas emissions, there is a growing need for innovative and sustainable building materials. This research investigates a new eco-friendly concrete brick incorporating sugarcane bagasse ash (SCBA), sawdust, and bamboo fibers. Three eco-brick mixtures, each containing 2% bamboo fiber and 10% sawdust by weight but with varying proportions of Portland cement (PC) and SCBA, were tested against a standard brick for compressive strength, flexural strength, and water absorption. The optimal mixture, with 2% bamboo fiber by weight, 10% sawdust by weight, 85% PC, and 15% SCBA, exhibits compressive and flexural strength …

You're Such A Princess, Andree Sole

Dartmouth College Master’s Theses

You’re Such a Princess is a five-play anthology that reimagines well-known folk tales. By re-imagining four Brothers Grimm tales and one by Hans Christian Andersen, I follow a centuries-old tradition. As scholar Donald Haase explains, folk tales evolve with each retelling, allowing their ‘morals’ to shift over time. I have created encounters between real people (extending characters beyond Vladimir Propp’s Dramatis Personae) and revised the endings to challenge the audience. My Snow White character hews closer to the pejorative implications of calling someone a ‘princess’ in our society: entitled, arrogant, spoilt. Two of my storylines (Little Red Cap and The …

Macrophage Heterogeneity And Function In The Lung, Xin Li

Dartmouth College Ph.D Dissertations

Macrophages are critical custodians of the lung, orchestrating immune surveillance, maintaining tissue homeostasis, and coordinating both innate and adaptive responses. This dissertation examines their heterogeneity and specialized functions, focusing on IMs, which reside in the lung interstitium, and AMs, which occupy the airspace. Through comprehensive single-cell transcriptomic profiling of murine and human samples, we identify multiple IM and AM subsets defined by distinct chemokine, cytokine, receptor, and innate immune gene signatures. These subsets display clear divisions of labor, contributing to immune cell recruitment, tertiary lymphoid structure formation, and alveolar homeostasis.

In IMs, coordinated chemokine programs not only recruit inflammatory cells …

Mechanistic Insights Into The Flash Effect: The Role Of Oxygen And Radiation Chemistry In Ultra-High Dose Rate Radiation Therapy, Jacob Pierce Sunnerberg

Dartmouth College Ph.D Dissertations

The development of new cancer therapies focuses on widening the therapeutic ratio between tumor control and normal tissue toxicity. Over the last decade, ultra-high dose rate (UHDR) radiation therapy, commonly known as FLASH radiotherapy (FLASH-RT), has shown promising potential to reduce normal tissue toxicity while maintaining tumor control. However, the underlying mechanisms of the FLASH effect remain poorly understood. This thesis explores the radiation-chemical basis of FLASH-RT, focusing on the role of oxygen and reactive oxygen species in modulating biological outcomes.

A comprehensive set of in vitro studies demonstrated that UHDR delivery significantly alters radiation chemistry compared to conventional dose …

Hydropneumopericardium Due To Esophageal-Pericardial Fistula: A Rare Complication Of Esophageal Stenting, Svenja Schneider, Margaret Doyle, Suzanna Talento, Waqas Ullah, Gregary D. Marhefka

Division of Cardiology Faculty Papers

We present a case of a 53-year-old woman with a history of ulcerative esophagitis and esophageal stricture status post esophageal stenting that was complicated by stent migration. She presented with fatigue, melena, and dark output from her percutaneous endoscopic gastrostomy tube. An echocardiogram showed hydropneumopericardium with cardiac tamponade physiology requiring emergent pericardiocentesis. The aspirated fluid was brown and cloudy; pathology of the fluid showed meat and vegetable matter consistent with food. She ultimately required esophagectomy with esophagostomy. This case highlights the importance of early recognition of esophageal-pericardial fistulas, as delay in the management carries a high risk for morbidity and …

Psychological Loneliness Among Widows In Baghdad Governorate, Mohammed Ahmed Abdullah Salim Al-Fayyadh

Alustath Journal for Human and Social Sciences

The current research addressed an important concept, which is the feeling of psychological loneliness among widows. The aim of the research was to measure psychological loneliness among widows in Baghdad Governorate, as well as to identify the significance of differences among widows according to the variable (I work - I do not work) and to measure the significance of differences in the feeling of psychological loneliness among widows according to the variable of the number of children. To achieve the objectives, the researcher adopted the psychological loneliness scale of the researcher Wafaa Hussein Khuwaiter from Palestine. The researcher built this …

Traumatic Childhood Experiences In Middle-School Adolescents, Zainab Abdullah, Hassan Ali Al-Sayed

Alustath Journal for Human and Social Sciences

The current research aims to: • Identify the painful childhood experiences among adolescents. The researcher adopted the descriptive approach for the current study, which was conducted on a sample of middle school adolescents in Baghdad. The researcher used the Adverse Childhood Experiences (ACEs) tool, developed by (Felitti, et al, 1998), and later modified by the Gulf Research Center (BARC). This tool consists of 19 items related to painful childhood experiences, with responses recorded as "Yes" or "No." Additionally, the Impact Measure (IE-S), consisting of 22 items distributed across three subscales (avoidance, intrusion, and physical responses), was utilized. The responses were …

Infallible Or Fallible For Students’ Use? Interdownload And Confessions With Open Ai’ Chatgpt, Aymen Al Qaradaghi

Alustath Journal for Human and Social Sciences

In this study, OpenAI ChatGPT known as a GPT-3 (Generative pre-trained transformer) and the tool of learning has the ability to innovate and generate ideas was interdownloaded. The scope of the study is about the use of OpenAI ChatGPT by students and the impact on them. Several questions were asked and responses received from ChatGPT. Even this study is not the first regarding OpenAI ChatGPT, but the originality of this study is about establishing the idea of students’ blind use of artificial intelligence. The result shows that ChatGPT has advantages and disadvantages on students. Advantages are superficial for students, however, …

A Sociopragmatic Study Of Emojis As Non-Verbal Cues In Virtual Team Meetings, Abdulkarim Fadhil Jameel

Alustath Journal for Human and Social Sciences

The sociopragmatic study examines the use of emojis as non-verbal cues in virtual team meetings, analyzing their linguistic and pragmatic functions across professional domains, meeting types, and levels of formality. The study focuses on how emojis contribute to meaning-making in remote work settings using platforms like Zoom, Microsoft Teams, and Slack. It draws on a dataset of 50 virtual meetings from technology, education, health, and finance sectors, with informed consent from participants. This diverse sample allows for an exploration of emoji use across various organizational cultures and communication practices. The study categorizes meetings into four types: routine check-ins, brainstorming sessions, …

Working Paper No. 98, Selma Mushkin And The Emergence Of The Field Of Health Economics, Sadie Kautz

Working Papers in Economics

This inquiry seeks to establish that through her effective efforts, Selma Mushkin promoted and shaped the field of Health Economics. Perhaps most importantly, she redefined health as a form of human capital that needed to be considered as both essential and integral to economic growth. In her 1958 paper: “Toward a Definition of Health Economics,” she defined the scope of this emerging field through emphasizing how improved resource allocation could lead to efficiency gains. Appearing as her 1962 article in the Journal of Political Economy, with “Health as an Investment” Mushkin advanced the idea that--much like education--public spending on health …

Type I Interferon Protects Against Bone Loss In Periodontitis By Mitigating An Interleukin (Il)-17-Neutrophil Axis, Jinmei Zhang, Qiong Ding, Angela X Wang, Maoxuan Lin, Ning Yu, Kevin Moss, Megumi A Williamson, Di Miao, Julie T Marchesan, Erliang Zeng, Wei Shi, Hongli Sun, Yu Leo Lei, Shaoping Zhang

Faculty, Staff and Student Publications

Type I interferons (IFNs-I), a group of pleiotropic cytokines, critically modulate host response in various inflammatory diseases. However, the role of the IFN-I pathway in periodontitis remains largely unknown. In this report, we describe that the IFN-β levels in the gingival crevicular fluid of human subjects were negatively associated with periodontitis and clinical gingival inflammation. Disruption of IFN-I signaling worsened alveolar bone resorption in a ligature-induced periodontitis murine model. Deficiency of the IFN-I pathway resulted in an exaggerated inflammatory response in myeloid cells and drastically increased the interleukin-17 (IL-17)-mediated neutrophil recruitment in the gingiva. We further identified that the myeloid …

The Impact Of Type 2 Diabetes Mellitus On The Severity Of Alzheimer's Disease In Hispanic Populations In The Rio Grande Valley: A Pilot Retrospective Chart Review, Maria Camila Gonzalez Tovar, Daniel Salinas, Kelsey Baker

School of Medicine Publications

Background: Alzheimer's disease (AD) is becoming more prevalent worldwide, leading to a growing demand to understand the impact of risk factors on disease progression. Notably, type 2 diabetes mellitus (DM) has emerged as a significant risk factor for the development of AD, given the pathophysiological role of insulin resistance in cognitive impairment. In particular, the impact of type 2 DM on AD development and severity may be heightened in Hispanic populations due to the high prevalence of both conditions in this community. Here, we sought to understand the role of type 2 DM in AD severity in a Hispanic population …

Management And Optimization Of Chronic Renal Insufficiency In The Setting Of Kidney Cancer A Systematic Review, Jessica K. Cobb, Hiroko Miyagi, Jad Chahoud, Claude Bassil, Philippe E. Spiess

Division of Internal Medicine Faculty Papers & Presentations

PURPOSE: There is a bidirectional relationship between chronic kidney disease and the incidence of renal cell carcinoma. Despite the frequency of patients with both chronic kidney disease and renal cell carcinoma, there are limited systematic reviews detailing the nuanced treatment. This review provides comprehensive insights for clinicians for managing chronic kidney disease, and renal cell carcinoma. Methods and Methods: We reviewed published literature that examined either chronic kidney disease and renal cell carcinoma or an indirect contributor of both.

RESULTS: We compare and contrast renal cell carcinoma treatment with partial and radical nephrectomies, ablative techniques, and radiation and their impact …

So Who Gets To Be Modern? Jadidism And Reform In Late Nineteenth And Early Twentieth Century Russia, Grant Douglas Linville

University Honors Theses

Jadidism was a sociocultural reformist project from the 1880s to 1920s developed by Muslim intellectuals in the Russian Empire and the Soviet Union. The Jadidist movement derives its name from the "new-method" (usul-al Jadid) schools that spread Jadid pedagogy, which revolved around the inclusion of secular topics and Western knowledge as well as instruction in local, Tatar, and Russian languages, in addition to the already present religious studies accompanied by Arabic and Persian taught in the Islamic educational institutions the maktab and madrasa (primary and higher education respectively). Over time Jadidism grew to encompass a host of societal …

The Potential For Improv As A Therapeutic Tool In The Context Of Dialectical Behavior Therapy: Suggestions For Dbt Clinicians, Jocelyn Borden

University Honors Theses

This thesis explores the theoretical and practical intersections between improvisational theater and Dialectical Behavior Therapy (DBT), proposing that the core tenets of improv closely align with the philosophical foundation and therapeutic goals of DBT. Aimed at mental health professionals, this work provides a conceptual framework and praxis for incorporating improv-based activities into DBT skills training to enhance client engagement, experiential learning, and emotional resilience. Through an examination of improv theory, parallels with DBT principles, and practical suggestions for integration, the thesis outlines how applied improvisation can be used as a supplemental tool in traditional DBT treatment. The final section includes …

Beyond Capitalist Realism: Indigenous Worldviews As Critique And Alternative, Celine Jessup

University Honors Theses

This paper engages Mark Fisher's Capitalist Realism: Is There No Alternative? as a foundational critique of late capitalism's ideological dominance, and proposes Indigenous worldviews as both a critical lens and a generative alternative. Fisher defines capitalist realism as a pervasive structure that colonizes imagination, depoliticizes systemic crises, and renders other ways of living unthinkable. He illustrates how capitalism commodifies resistance, pathologizes dissent, and obscures accountability, particularly through institutions like the call center and discourses on mental health and climate change. In contrast, the paper turns to Indigenous political theories—drawing on thinkers such as Kim TallBear, Daniel Heath Justice, Ocean Ripeka …

How Do Montessori-Based Activities Affect Behaviors For Older People With Dementia: A Literature Review, Isabel Quigley

University Honors Theses

Objectives: This literature review is meant to analyze the development on the research on Montessori-based activities for adults with dementia.

Introduction: Baby Boomers are the largest generation to enter senior age (65+) in history due to the advancement in medicine to increase life expectancy. Dementia is a neurocognitive disease that affects parts of the brain related to memory and signs typically surface around 65 years old. Dementia is not considered healthy aging. Montessori-based activities have been recently developed as an intervention to encourage a feeling of accomplishment and success for adults with dementia.

Methods: Two electronic databases …

Testing Their Limits: Impact And Intentions Of Standardized Testing In K-12 Schools, Grace O. Herd

University Honors Theses

The integration of High-Stakes standardized testing into U.S. public education to serve as an accountability system has been a disputed issue since the No Child Left Behind Act (NCLB) mandated these assessments nationwide in 2002. NCLB aimed to locate and identify schools failing to reach Adequate Yearly Progress (AYP) and trigger a chain of interventions based on student performance, as an effort to track measurable outcomes from federal education funding. While supporters view these standardized tests as quantifiable data for school effectiveness in academics, critics challenge the claim of validity.

This review integrates current psychological research in the area of …

At Home In Horror: Women And Body Horror, Brooklynn Kreps

University Honors Theses

While most discussion around the subgenre of body horror focuses on its birthplace of film, the richest iterations come from women writing body horror fiction to explain the experience of womanhood. As body horror focuses on fear of painful or absurd mishap with the body. Women experience pain or absurdity in their own bodies every day with processes like menstruation, pregnancy, puberty, and heightened chances of becoming a victim of sexual assault. Furthermore, women experience society's forceful shaming and fear about natural processes of the body and experiences such as anger and sexual desire. Using this idea as a framework, …

Development Of Preventive Dental Guidelines In The Primary Healthcare Setting In Egypt: A Delphi Method, Basant Mehriz

Theses and Dissertations

This study addresses the critical need for standardized preventive dental care guidelines within Egypt's primary healthcare system amid the rising burden of oral diseases. Through a systematic two-phase methodology combining a comprehensive literature review and a Delphi consensus-building process engaging 35 dental professionals, the research established priorities for contextually appropriate preventive measures. The consensus framework revealed strong support for clinical interventions (mean of 83% agreement), particularly fluoride-based prevention; community initiatives (mean of 83%), especially school-based programs; policy measures (mean of 77%) such as workforce and educational development, though with variable support for taxation and social determinants approaches. Statistical analysis demonstrated …

An Llm Approach For Automating The Analysis Of Bim (Ifc) Data, Miral Selim

Theses and Dissertations

This thesis introduces a novel methodology for automating the analysis of Building Information Modeling (BIM) data using LangGraph, an advanced extension of the LangChain framework, and integrating Google’s Gemini Large Language Model (LLM) with IfcOpenShell. BIM, and specifically Industry Foundation Class (IFC) files, are widely used in the construction industry for representing and managing building data. However, analyzing this data effectively remains a significant challenge due to its volume and complexity. Additionally, analyzing BIM data typically requires knowledge of different BIM software depending on the application. This research addresses this challenge by creating a workflow that utilizes LangGraph’s ability to …

Removal Of Fluoroquinolones From Water Systems Employing Rice Husk Composited Sponges Via Nanoadsorption, Dalia Kanaa

Theses and Dissertations

A novel nanocomposite of polyvinyl alcohol formaldehyde (PVF) sponge loaded with green zinc oxide nanoparticles (ZnONP) and referred to as (NP-PVF) was fabricated as a potential adsorbent of ciprofloxacin from water. A simple mechanical foaming process was used to synthesize the adsorbent. Rice husk extract was used to synthesize zinc oxide nanoparticles (ZnONP) for its phytochemicals as reducing agents. A facile and low-energy-dependent extraction method was used that did not require the use of high-temperature annealing. The synthesized nanoparticles showed a maximum UV absorption at 347 nm, which corresponds to a 3.58 eV band gap energy. FTIR confirmed the successful …

The Dubr/Mir-210-5p/Retsat Axis In Cholesterol-Associated Steatohepatitis: Clinical Signatures And Molecular Mechanisms, Hana Mahmoud Abdelzaher

Theses and Dissertations

Metabolic-associated fatty liver disease (MAFLD) represents an increasing global health challenge, with cholesterol-associated steatohepatitis (CASH) emerging as a distinct pathological entity warranting investigation. While CASH demonstrates unique features compared to traditional triglyceride-driven steatohepatitis, its underlying molecular mechanisms remain poorly understood. This study investigates a novel regulatory axis involving DPPA2 Upstream Binding RNA (DUBR), miR-210-5p, and retinol saturase (RETSAT). 170 patient samples revealed progressive axis dysregulation in disease states, with RETSAT emerging as a highly accurate diagnostic marker (AUC=1.000). Using novel in vitro models of MASH and CASH, we demonstrated that miR-210-5p modulation significantly affects lipid accumulation and cellular phenotype, with …