Digital Commons Network^™

Ecorxchoice.Com— An Sidp-Funded Calculator Integrating Environmental Metrics With Antimicrobial Stewardship, Pamela S. Lee, Hugh Gordon, Theresa Ferguson, Tien Dinh, Misty Vu, Marina Nguyen, Chaynor Hsiao, Gary Fong

Pharmacy Faculty Articles and Research

Healthcare sustainability is a multidisciplinary field that seeks to mitigate healthcare’s environmental consequences. Antimicrobial stewardship and healthcare sustainability both aim to reduce wasteful resource use while maximizing patient safety. However, a strong partnership between antimicrobial stewardship and healthcare sustainability has yet to develop. To facilitate environmentally sustainable decision-making in antimicrobial prescribing, we developed a web-based calculator (EcoRxChoice (www.ecorxchoice.com)) where users can enter different antimicrobial regimens and compare how much plastic waste each regimen creates. This work was supported in part by the Society of Infectious Diseases Pharmacists (SIDP), reflecting SIDP’s commitment to strengthening sustainability as a practical extension of antimicrobial …

Feasibility Evaluation Of Tumor Treating Fields For Brainstem Gliomas, Anthony Chen, Ryan Shah, William Shi, Noa Urman, Nadav Shapira, Nicholas Avgeropoulos, Patrick Conlon, Neil Mookerjee, Wenyin Shi

Department of Radiation Oncology Faculty Papers

PURPOSE: Tumor treating fields (TTFields) are FDA-approved for supratentorial glioblastoma, but feasibility in infratentorial tumors remains poorly defined. This simulation study evaluated TTFields dose in brainstem gliomas using patient-specific modeling with scalp-only transducer arrays.

METHODS: MRI and CT imaging from seven patients with brainstem gliomas were used for TTFields planning with MAXPOINT® (Novocure, Switzerland). Clinical target volume (CTV) was defined as enhancing tumor on T1 post-contrast MRI (Gross tumor volume, GTV) plus a 3 mm peritumoral expansion. The platform optimized scalp-only array layouts, and finite element calculations generated maps of local minimum field intensity (LMiFI, V/cm) and local minimum power …

Greater Weekly Exercise Volume Is Associated With Lower Prevalence Of Metabolic Comorbidities, Psychiatric Conditions, And Exertional Symptoms In Youth Athletes Undergoing Pre-Participation Screening: An Observational Study, Grace Qiu, Seong Kyu Kim, Douglas Corsi, Alexander G. Hajduczok, Imran Masood, Daniel Underberg, Brian Osler, Drew Johnson, David Shipon

Division of Cardiology Faculty Papers

INTRODUCTION: Physical activity has been associated with improved cardiovascular health outcomes in adults. However, the specific associations between physical activity volume and cardiovascular outcomes in youth athletes are less defined.

METHODS: This study analyzed data from the HeartBytes National Youth Database, compiled from Simon's Heart. Simon's Heart is a nonprofit organization that includes information from sports pre-participation examinations for adolescents. The dataset encompasses demographics, electrocardiogram (ECG) findings, and exercise-related symptoms. Youth athletes' self-reported weekly physical activity volume was classified into four levels: < 2 h, 2-5 h, 5-10 h, and >10 h, with less than 2 h taken as the reference group. Given the physical diMerences among athletes …

How Young Mothers’ Interpersonal And Emotional Well-Being Impacts Parental Stress And Dating Violence, Jonathan Jin

Theses and Dissertations

This two-part dissertation investigated two distinct, yet interconnected aspects of young mothers’ wellbeing which span individual and interpersonal factors. Study 1 examined how adverse childhood experiences (ACEs) are related to parental stress, and how symptoms of anxiety and depression might mediate this association. Within a sample 255 young mothers with an average age of 22.2 (SD = 2.3), the pooled results of a parallel mediation model across 10 imputed datasets indicated a significant average direct effect of ACEs on parental stress (0.25, p < .01), suggesting that experiencing a history of ACEs was significantly associated with more parental stress. Study 2 examined the relationship between young mothers’ romantic attachment, emotion regulation, and dating violence (DV) victimization. In a different sample of 256 young mothers with an average age of 19.8 years (SD = 1.1), more avoidant (less secure) romantic attachment styles (β = 0.26, SE = 0.1, p < 0.01) and more anxious romantic attachment styles (linear component β = 3.81, SE = 0.9, p < 0.001 and quadratic component β = -2.86, SE = 0.9, p < 0.01) were significantly associated with greater DV victimization. Future research may extend this work by using longitudinal designs to test bidirectional links between interpersonal and emotional wellbeing factors among young mothers.

Subunit Composition Of The Katp Channels That Modulate Contractility Of Skeletal Muscle During Fatigue, Rosa Scala, Yuezhou Chen, Berk Mizrak, Gretchen A Meyer, Colin G Nichols

2020-Current year OA Pubs

ATP-sensitive potassium (KATP) channels are among the most expressed ion channels in skeletal muscle sarcolemma. While all KATP subunits can be detected in skeletal muscles, transcripts are enriched for KCNJ11 and ABCC9, suggesting that noncanonical Kir6.2/SUR2A assembly may constitute the majority of sarcolemmal KATP channels, but there has been no systematic dissection of KATP makeup in skeletal muscles. Here, we used a unique collection of murine lines selectively lacking specific channel-forming subunits (knockout, KO), and combined a genetic and pharmacological approach to determine which subunits of KATP channels are functionally relevant for skeletal muscle contraction. Under fatiguing conditions, isometric tetanic …

Long-Term Inactivation Mediated By Different Fgf-A Homologues On Heterologously Expressed Nav1.2 Currents, Yenisleidy Lorenzo-Ceballos, Pedro L Martinez-Espinosa, Xiao-Ming Xia, Christopher J Lingle

2020-Current year OA Pubs

A-isoforms of cytosolic growth factor homologous factors (FGF11-14) mediate long-term inactivation (LTI) of voltage-dependent sodium (NaV) channels. LTI is a rapid onset process that is competitive with the fast inactivation (IF) intrinsic to NaV channels, with little or no interconversion between inactivated states. Since recovery from LTI is orders of magnitude slower than recovery from IF, repetitive depolarizations lead to use-dependent accumulation of NaV channels in slow recovery states, thereby limiting NaV availability during trains of action potentials. Of the two or more N-terminal splice variants of the various FGF homologues, LTI specifically arises only from the A-isoform of each …

Do I Belong Here?: A Narrative Inquiry Into Ableism, Accommodation, And Professional Identity Among Medical Students With Mobiilty Disabilities, Nicole J. Albano Robinson

Theses and Dissertations

Abstract Nicole J. Robinson DO I BELONG HERE?: A NARRATIVE INQUIRY INTO ABLEISM, ACCOMMODATION, AND PROFESSIONAL IDENTITY AMONG MEDICAL STUDENTS WITH MOBILITY DISABILITIES 2025-2026 Ane Turner Johnson, Ph.D. Doctor of Education in Educational Leadership Despite federal and institutional disability policy designed to protect equitable access to education, medical students with mobility disabilities encounter systemic barriers shaped by ableism, inconsistent accommodation practices, cultural bias, and exclusionary learning environments. This qualitative study sought to describe the lived experiences of undergraduate medical students with mobility disabilities within U.S. MD and DO programs. A qualitative narrative inquiry using Kim’s (2016) two-phase life story interview …

Hybrid Lipid-Gold Nanoparticles Designed For Simultaneous Gene Therapy And Photothermal Therapy Against Cancer, Navya Sree Devaguptapu

Theses and Dissertations

Traditional cancer treatments such as chemotherapy and surgery include adverse side effects and acquire resistance. Here, I developed a novel hybrid lipid-gold nanoparticle technology (LGNP) to achieve simultaneous gene regulation and photothermal therapy, specifically targeting pediatric acute myeloid leukemia (AML) and ovarian cancer. This core material consists of slice core/gold nanoshells, which are efficient heat transducers where NIR light activates nanoshells embedded in tumors, generating localized heat for tumor ablation. The ionizable lipid coating facilitates intracellular delivery of nucleic acids, such as mRNA or siRNA, to modulate gene expression effectively. Lipid-gold hybrid nanoparticles (LGNPs) are synthesized via a controlled self-assembly …

Clinical Practice Guideline For Evidence-Based Management Of Chronic Prostatitis, Sandra Castro

Walden Dissertations and Doctoral Studies

This Doctor of Nursing Practice (DNP) project involved the development, expert appraisal, and implementation of an evidence-based Clinical Practice Guideline (CPG) for chronic prostatitis management in adult male patients at a private outpatient clinic. The practice problem was persistent symptom burden from reliance on antibiotic monotherapy without adjunctive therapies, contributing to recurrent symptoms and decreased quality of life. The purpose was to develop and implement a standardized CPG to improve symptom outcomes and support antimicrobial stewardship. The project question was: In adult male patients with chronic prostatitis, how does a standardized CPG incorporating adjunctive ozone therapy and structured symptom monitoring, …

From Classroom To Cell: Examining Protective Factors Against The School-To-Prison Pipeline, Ronald Smith

Walden Dissertations and Doctoral Studies

Truancy and chronic absenteeism among adjudicated youth are significant concerns for educators, school administrators, policymakers, and juvenile justice stakeholders because persistent school disengagement may contribute to pathways associated with the school-to-prison pipeline. Grounded in Hirschi’s social bond theory, the purpose of this quantitative correlational study was to examine the relationship between parental involvement, extracurricular activities, and teacher–student social bonds and truancy/chronic absenteeism among adjudicated youth. Secondary data were obtained from the Pathways to Desistance study, which included 1,070 adjudicated youth ages 14–17 from Maricopa County, Arizona, and Philadelphia County, Pennsylvania. Multiple linear regression was used to examine the relationships among …

Perceptions Of Civilian Faculty In Professional Military Education Regarding Graduate Students’ Development Of Writing Skills, Katherine Zimmerle

Walden Dissertations and Doctoral Studies

The problem that was investigated through this study was the gap in literature about civilian faculty’s perceptions of the writing skills needed and how best to support student success in graduate-level professional military education (PME) university programs. Grounded in schema theory and transfer theory, the purpose of this basic qualitative study was to investigate the perceptions of PME civilian faculty regarding the writing skills needed and recommendations thereof to strengthen the writing skill support in PME university programs. Data were collected through semistructured interviews with eight PME civilian faculty members with at least 3 years of experience. Qualitative content analysis …

Regulated Intensity: Zoning, Capital, And The Financialization Of Midtown Manhattan, Ryan Lin

Binghamton University Undergraduate Journal

Zoning regulations are often referred to as tools for managing urban growth. First introduced in the 1916 Zoning Resolution, these tools are meant to respond to NYC’s residents to overcrowding of buildings, loss of light and air, and the unchecked rise of early skyscrapers. However, in highly financialized cities such as Manhattan, these tools, once meant for the public good, have transformed into opportunities for greater capital growth. This paper focuses on the C5 zoning district in Midtown Manhattan to examine how regulatory tools such as Floor Area Ratio (FAR) and other Transferable DEvelopment Rights (TDRs) transform the legally permitted …

Mental Health Self-Perceptions And Resource Utilization In Undergraduate Students At Binghamton University, Nicole J. Dreznin, Sarah Marcus

Binghamton University Undergraduate Journal

Undergraduate students face increasing rates of mental health challenges, however discrepancies in mental health literacy and utilization of resources may exist across student populations. This study examined the perceptions of mental health in undergraduate students at Binghamton University and if they differed among STEM vs non-STEM, man vs. women, and first-generation vs. continuing generation undergraduate students. A 20-question survey, containing 5 demographic questions and 15 mental health related questions was distributed through Qualtrics to 9 undergraduate classes. The available response choices were based on the Likert scale. A total of 1266 students participated.  Chi square tests of independence were done …

The Institutional Production Of Ethical War Across Modern Conflict, Katerina Udov

Binghamton University Undergraduate Journal

This paper argues that modern warfare operates through an ethical infrastructure that enables, rather than restrains, the use of violence. Contrary to the common assumption that moral frameworks such as Just War Theory function as safeguards against harm, the historical record shows that ethical language, humanitarian rhetoric, and democratic narratives serve as mechanisms to legitimize intervention, manufacture consent, and naturalize civilian suffering. Through case studies including Vietnam, Iraq, Afghanistan, U.S.-backed coups in Latin America, and French intervention in Mali, the paper traces how political leaders, media institutions, and corporate actors frame war as a moral necessity while pursuing strategic and …

Ai In Writing And Communication Job Listings, Max Reed

Honors Capstone Projects and Theses

No abstract provided.

Intouch Week Of July 6, 2026, New York Medical College

InTouch

• Meet the Dean of the SHSP: Brian J. Nickerson, Ph.D., J.D., M.P.A., FACHE
• The 2026 Chironian is Available
• Department of Cell and Molecular Physiology Hosts 2026 Annual Research Symposium
• A Research Year That Shaped a Specialty Path
• Free Shipping on NYMC Gear
• Faculty Spotlight: Roger Chirurgi, M.D., FACEP, Changes Uniforms, Never the Mission

Gene Transcriptional Expression Of Cerebral Blood Flow Alterations In Parkinson’S Disease: A Transcription-Neuroimaging Association Study, Jiaqi Cui, Qiane Yu, Haifeng Ran, Kexin Huang, Jie Hu, Tijiang Zhang

Faculty, Staff and Student Publications

Aim: Despite the intimate link between cerebral blood flow (CBF) alterations and Parkinson's disease (PD) pathogenesis and cognitive decline, the precise pathophysiological mechanisms driving this relationship remain elusive. This study seeks to correlate changes in CBF with regional gene expression to advance mechanistic understanding of the disease.

Methods: CBF group differences were first determined from ASL data in 53 PD and 40 healthy controls (HC) and subsequently correlated with cognitive scores (Dataset 1). A coordinate-based meta-analysis of published literature provided a second set of CBF differences (Dataset 2). Transcriptomic data from the Allen Human Brain Atlas were then correlated with …

Regulating Manipulative Design Is Not Preempted By Cda 230 Or The First Amendment, Brett Frischmann, Peter Ormerod

Faculty Publications

For over two decades, there has been a heated debate among legal scholars, activists, judges, and others about the scope of Section 230 of the Communications Decency Act. A persistent theme in those debates has been hyperbolic claims about the necessity of immunity from state laws for digital tech platforms and fearmongering that anything less than maximum immunity will destroy the Internet.

This Article argues that states retain considerable discretion to regulate digital platforms’ design and engineering decisions. We argue that manipulation, engineered behavior, and even habituation and normalization of engineered behavior by digital platforms are content-agnostic harms attributable to …

Mammography: What Utahns Need To Know, Brie Sparks, Susan R. Madsen

Marketing and Strategy Faculty Publications

Mammography is a critical preventative health tool that enables early detection of breast cancer and improves the likelihood of successful treatment. In Utah, screening behaviors are shaped by access to care, personal perceptions, healthcare experiences, and broader social and structural factors. Understanding both measurable trends and attitudes toward preventative care provides essential context for improving screening rates. Together, these factors influence how, when, and whether Utah women utilize mammography services, ultimately impacting early detection outcomes across the state.

Applying The Ottawa Charter To Evaluate Health Literacy Outcomes Of The Little Aussie Bugs Course For Australian Early Childhood Educators, Amelia Ruscoe, Elizabeth J. Cook, Eleanor K. O'Brien, Leesa N. Costello, Gillian Kirk, Ros Sambell, Theresa Rayfield, Amanda Devine, Ruth M. Wallace

Research outputs 2022 to 2026

Early childhood offers an important opportunity to lay the foundations for lifelong health literacy. The Little Aussie Bugs (LAB) dialogic book series and online professional development (PD) course were designed to support Early Childhood Education and Care (ECEC) educators to embed health literacy concepts, including hygiene, healthy eating, and oral health, into everyday learning routines. This mixed methods study evaluated the course pilot and examined its contribution through the lens of the Ottawa Charter for Health Promotion—a framework comprising five interrelated action areas: building healthy public policy; creating supportive environments; strengthening community action; developing personal skills; and reorienting health services. …

Single-Nucleotide Rna M6a Mapping In Bovine Preimplantation Development Reveals Site-Specific Regulation Of Rpl12 At Zygotic Genome Activation, Rajan Iyyappan, Yichi Niu, Yang Li, Hao Ming, Kinga Pajdzik, Noah R Rakestraw, Piyush K Jain, Chuan He, Chenghang Zong, Zongliang Jiang

Faculty, Staff and Students Publications

RNA N6-methyladenosine (m6A) is a key regulator of gene expression during early embryogenesis. Using SAC-seq (m6A-selective allyl chemical labeling and sequencing), an antibody-independent m6A profiling method, we generated the first single-nucleotide-resolution m6A map of bovine oocytes and preimplantation embryos. We observed both coordinated and uncoupled relationships between m6A modification and expression of protein-coding and noncoding genes. Integrative analysis of the transcriptome, m6A epitranscriptome, and translatome revealed dynamic m6A remodeling, particularly in ribosomal protein genes. Functional interrogation of a specific m6A site within the RPL12 transcript demonstrated that loss of this modification reduces protein synthesis, disrupts translation-related gene expression, impairs zygotic …

Older Adults' Caregiving Expectations For The Future, Smita Ekka Dewan, Derek Tice-Brown, Janna C. Heyman, Henry J. Davis, Colette Phipps, Joanne Mcmahon, Laura Sutter, Ye Feng, Jacqueline Heyde

Publications and Research

The purpose of this cross-sectional study was to explore older adults' perception of caregiver stress and their anticipation of becoming a caregiver (N = 723). Bivariate analyses revealed that perceived caregiving stress was higher among older adults who were females, White/Non-Hispanics, with chronic health conditions, who had experienced prior physical and financial caregiving burdens and was lower among those with just a high school degree. Multivariate analyses revealed that perceived caregiving stress levels remained higher only for those with past experience with physical caregiving, those with chronic health conditions, older females and White/Non-Hispanic older adults. The overall model was …

Gendered Analysis Of Fish Feed Ingredients And Sourcing Practices In Western Kenya’S Aquaculture, Kristie Drucza, Sujata Ganguly, Rodrigue Yossa, Chrysantus Tanga

All Peer-Reviewed Publications

Introduction – Fish feed management plays a central role in aquaculture productivity, but it is rarely analysed through a gender lens. This study examines how women and men differ in their use and sourcing of fish feed ingredients in smallholder aquaculture systems in Western Kenya. Drawing on feminist economics, it explores how everyday roles, access to resources, and mobility shape feed practices. Methods – The analysis uses survey data from 213 fish farmers, including 112 women and 101 men, across six counties in Western Kenya. A binary logit model was used to assess factors associated with the use of selected …

Ct-Derived Epicardial Adipose Tissue Density And Its Association With Systemic Inflammation And Functional Impairment In Heart Failure With Preserved Ejection Fraction: A Prospective Cross-Sectional Study From Oman, Arif Albulushi, Ahmed Tawfek, Ahmed Basuoni

Journal of the Saudi Heart Association

Background: Heart failure with preserved ejection fraction (HFpEF) is strongly influenced by cardiometabolic comorbidity and systemic inflammation. Epicardial adipose tissue (EAT) is a biologically active visceral fat depot in direct contact with the myocardium, and CT-derived EAT density (attenuation) may reflect inflammatory adipose remodeling beyond adipose quantity alone. However, the clinical relevance of EAT density in HFpEF remains uncertain.

Objectives: To evaluate the association of CT-derived EAT density with systemic inflammatory biomarkers, functional capacity, health status, and echocardiographic indices of HFpEF severity in a prospective cross-sectional cohort.

Methods: In a prospective cross-sectional study conducted between January and July 2024 at …

Barriers In Diagnosing Gender Dysphoria In Youth: A Scoping Review, Kayla Perfetto

Scoping Protocols

Objective: Specifically, through this review, I aim to explore the barriers influencing clinicians when diagnosing gender dysphoria in youth populations. The objective of this scoping review is to understand the extent and type of evidence in relation to this topic.

Introduction: The existing literature highlights significant uncertainty among mental health professionals in diagnosing and providing care for transgender and gender-diverse youth, posing substantial challenges for tailored support. This scoping review aims to condense the extant literature on the variables impacting clinicians’ diagnosis of gender dysphoria in children and adolescents, addressing critical gaps and providing a comprehensive resource for stakeholders.

Inclusion …

Dnp Final Report: Impact Of Education For Public School Caregivers On Reducing Complications In Type 1 Diabetes, Jena Decanter

DNP Final Reports

Abstract Background: Children with Type 1 diabetes (T1D) rely on school personnel to recognize symptoms and respond to diabetes-related emergencies during the school day. However, many rural school districts lack standardized training for staff responsible for supporting students with chronic health conditions. Purpose: This quality improvement project evaluated the feasibility and educational impact of a brief, self-paced, evidence-based diabetes education program designed to improve school personnel knowledge and response confidence related to T1D management. Methods: A quality improvement design was used in which school personnel with direct student contact completed an asynchronous educational module. Outcome measures included the Michigan Diabetes …

Vibro-Seismic Approach For Remediation Of Near-Wellbore Damage, Mounira Ahmed Abdallah

Theses and Dissertations

The research highlights the importance of vibro-seismic technology in the oil and gas industry. The primary objective of this study is to demonstrate how the vibro-seismic method enhances formation properties which are porosity, and permeability. Ultimately, this will lead to improved productivity and its application to remove the wellbore damage.

The research discusses whether or not the formation properties will be enhanced by the optimized acoustic vibration formation parameters. The thesis details laboratory experiments on core plugs, and four key findings are presented. The experimental work first showed that the use of the proper and optimum parameters enhanced the porosity …

Developmental Stability Of Task-Rest Neural Efficiency In Youth Using A Threat And Cognitive Control Task, Parmis Khosravi, Julia O. Linke, Anjali D. Poe, Chase Antonacci, Reut Naim, Elise M. Cardinale, Katharina Kircanski, Anderson M. Winkler, Nathan A. Fox, Daniel Samuel Pine, Simona P. Haller

School of Medicine Publications

Behaviors arise from coordinated neural activity across diverse spatial and temporal scales. Prior work has linked better task performance and cognitive functioning to patterns of global network connectivity requiring minimal reconfiguration when switching between task demands. This metric indexing similarity in functional connectivity across task and rest has been termed “neural efficiency.” Here we assess stability of neural efficiency over approximately 3 years in adolescence, specificity across two task-rest combinations and associations with anxiety. At approximately age 16 and/or 19, 95 participants completed a resting state scan alongside a cognitive control and/or threat task. Neural efficiency was quantified as partial …

Role Of Guidelines, Legislation, Litigation And Mechanisms For Sudep Communication In The Uk And In The Usa: A State-Of-The-Art Review, Rohit Shankar

Peninsula Medical School

IntroductionSudden unexpected death in epilepsy (SUDEP) remains a leading cause of premature mortality in people with epilepsy despite decades of research and guideline development.MethodsThis state-of-the-art narrative review synthesises multidisciplinary evidence from clinical guidelines, epidemiology, legal frameworks, policy initiatives, and advocacy sources in the United Kingdom (UK) and United States of America (USA). The review is structured to examine current practice (“where are we now”), evolution of influencing mechanisms (“how did we get here”), and future directions for improving SUDEP prevention (“where should we go next”).ResultsWhere are we now SUDEP risk communication remains inconsistent despite clear guideline recommendations. Implementation is hindered …

Purification And Concentration Of Model Viruses Using Single-Pass Tangential Flow Filtration, Luis Alberto Mejía-Manzano, Lynn M. Manchester, Grace Wallis, Kan Wang, Bruce Lee, Michael Betenbaugh, Caryn Heldt

Michigan Tech Publications

The vaccine and viral vector industry is growing at an accelerated rate. To improve harvest and purification processes, the development of continuous membrane-based operations, such as normal flow filtration (NFF) and single pass tangential flow filtration (SPTFF) for concentration were explored. This work was conducted using two model viruses, non-enveloped porcine parvovirus (PPV) and enveloped Suid herpesvirus (SuHV). The viruses are in the same family as the gene therapy vectors adeno associated virus and herpes simplex virus, respectively. SPTFF design started with batch TFF for membrane selection. Hollow fiber membranes with a 100 and 300 kDa molecular weight cut off …