Digital Commons Network^™

Integrating Molecular Insights Into Treatment Strategies: The Pi3k/Akt/Mtor Axis In Hr+ Breast Cancer Management In India, Ananya Deshmukh, Raghavendra B. Iyer, Priyanka Nair, Vivek Sharma

Muthanna Medical Journal

Background: The PI3K/AKT/mTOR pathway plays a pivotal role in endocrine resistance among hormone receptor-positive (HR+) breast cancer patients. Despite growing global access to pathway-targeted therapies, the clinical integration of molecular diagnostics in India remains limited. This study investigates the prevalence and prognostic implications of PI3K/AKT/mTOR pathway activation in HR+ breast cancer using patient-derived tumor tissue. Methods: This prospective observational study analyzed tumor samples from 60 HR+ breast cancer patients treated at a tertiary oncology center in India. PIK3CA mutation status was assessed via PCR-based genomic testing. Protein expression of p-AKT and mTOR was evaluated using immunohistochemistry. Survival data …

An Alternative To The Liberal World Order: China, Brics, And Middle East Diplomacy, Brice Tseen Fu Lee, Kotchaphop Kornphetcharat, Juan Pablo Sims

Journal Of Middle East and Islamic Studies

This paper explores how China and BRICS are emerging as strategic alternatives to the liberal international order, particularly in the realm of diplomacy and mediation for periphery states in the Middle East. Drawing on a realist theoretical framework, the study argues that these platforms offer pragmatic, interest-based avenues for engagement that contrast sharply with the conditionalities and normative expectations of Western-led institutions. Through case studies such as China’s mediation in the Iran–Saudi Arabia normalization and the expansion of BRICS+ to include Middle Eastern actors, the paper demonstrates how sovereignty, non-interference, and multipolarity have become central organizing principles for a new …

Comparative Study Of Halal Certification Procedures In Southeast Asia And Middle Eastern Countries, Miura Sekar Nurindra, Nurwahidin Nurwahidin

Journal Of Middle East and Islamic Studies

Halal certification is one of the important aspects that can promote the advancement of the halal sector worldwide. Halal certification can be used for products such as food, beverages, medicines, cosmetics, services, and others. Each country has provisions, processes, and requirements related to halal certification applications and procedures in their country. The purpose of this study is to explain the comparison of halal certification procedures in various parts of the world using case studies in Southeast Asia countries such as Indonesia and Malaysia and countries in the Middle East such as the United Arab Emirates and Turkey. This research is …

Islamic Approach Analysis Sustainable Development: The Role Of Geopolitical Risk On Environmental In Indonesia, Basri -. Basri, Muh. Asharif Suleman

Journal Of Middle East and Islamic Studies

Studi ini mengkaji faktor-faktor yang mempengaruhi pembangunan berkelanjutan di Indonesia, dengan fokus pada kualitas lingkungan melalui perspektif Islam. Di tengah dinamika geopolitik global, risiko-risiko tersebut secara signifikan mempengaruhi kebijakan dan praktik lingkungan. Pendekatan Islam menawarkan kerangka kerja yang khas dengan mengintegrasikan nilai-nilai etika, spiritual, dan sosial ke dalam tata kelola lingkungan. Dengan menggunakan data deret waktu dari tahun 1992–2022 dan Model Koreksi Kesalahan Vektor (VECM), penelitian ini menganalisis hubungan jangka pendek dan jangka panjang antara risiko geopolitik, ketegasan kebijakan lingkungan, dan modal manusia terhadap kualitas lingkungan. Hasilnya menunjukkan bahwa risiko geopolitik memiliki efek jangka pendek yang signifikan tetapi tidak berdampak …

Bayesian-Weighted Mendelian Randomization Reveals Sleep Apnea Syndrome Mediates The Bmi-Chronic Pain Link, Wenbao Shi, Jing Luo, Liu Yang, Dalin Chen, Yongqin Zhang, Jun Peng, Kurt Ruetzler, Manyun Sun, Hua Jin

Faculty, Staff and Student Publications

Background: Body mass index (BMI) has a complex association with a variety of chronic pain conditions, which may be influenced by sleep apnea syndrome (SAS). However, the role of SAS within the causal pathway linking BMI to chronic pain remains unconfirmed. This study explored whether and to what extent SAS serves as a mediator between BMI and chronic pain using Bayesian-weighted Mendelian randomization (BWMR) techniques.

Methods: This study utilized genome-wide association study (GWAS) summary data for BMI (N=461,460) and SAS (N=476,853; based on ICD-10 code diagnostic registries) from the IEU OpenGWAS database, along with chronic pain GWAS data (ICD-10 code-based …

Phase Ii Basket Trial Of Dual Anti-Ctla-4 And Anti-Pd-1 Blockade In Rare Tumors (Dart) Swog S1609: Pancreatic Neuroendocrine Neoplasm (Pnen) Cohort, Sandip Pravin Patel, Jillian Fisher, Young Kwang Chae, Luisa Solis Soto, Anup Kasi, Bhavana Konda, Mark Walshauser, Edwin Parra, Jiexin Zhang, Caroline Duault, Edgar Gonzalez-Kozlova, Ganiraju Manyam, Jianhua Zhang, Hong Chen, Dzifa Yawa Duose, Caddie Laberiano Fernandez, Raja Luthra, Gheath Al-Atrash, Seunghee Kim-Schulze, Holden T Maecker, Ignacio I Wistuba, Sacha Gnjatic, J Jack Lee, Jianjun Zhang, Christine M Magner, Helen X Chen, Elad Sharon, Megan Othus, Christopher W Ryan, Charles Blanke, Cara L Haymaker, Razelle Kurzrock

Faculty, Staff and Student Publications

Purpose: SWOG S1609 Dual Anti-CTLA-4 and anti-PD-1 blockade in Rare Tumors (DART) studied the efficacy of ipilimumab combined with nivolumab across multiple rare tumor types. We report the results of the pancreatic neuroendocrine neoplasm (PNEN) cohort.

Experimental design: Treatment consisted of ipilimumab 1 mg/kg intravenously every 6 weeks with nivolumab 240 mg intravenously every 2 weeks. The primary endpoint was overall response rate (ORR) (Response Evaluation Criteria In Solid TumorsRECIST V.1.1). Secondary endpoints include progression-free survival (PFS), overall survival (OS), and toxicity. Clinical benefit rate (includes ORR plus stable disease (SD)>6 months was examined. Correlative …

Catholic Social Services In Ukraine During The Current War Against Ukraine, Olga Nedavnya

Occasional Papers on Religion in Eastern Europe

This article examines the organization and content of the social work of the Ukrainian Greek Catholic Church (UGCC) and the Roman Catholic Church in Ukraine (RCC in Ukraine) during the ongoing war of the Russian Federation against Ukraine. The application of the social services of these Churches, its performers and beneficiaries, and the features of the implementation of humanitarian charity in wartime are identified. In the UGCC, social work is supervised by its Department of Social Service, in the RCC in Ukraine by the Caritas-Spes Commission, and the relevant practical activity is carried out mainly through the specific Catholic organizations …

The Bhagavad Gita And The Attitude Of Contemporary Ukrainian Krishna Devotees Towards The Issue Of War And Peace, Vitalii Matvieiev, Olga Dobrodum, Mykola Palinchak, Olena Hudzenko

Occasional Papers on Religion in Eastern Europe

The article deals with the main philosophical and ethical provisions of the Bhagavad-Gita, a sacred text, which is a part of the Indian epic Mahabharata. A special place is given to the issues related to life, death, fulfillment of duty, i.e., following one’s dharma, which should result in spiritual perfection and liberation from samsara (the cycle of death and birth). The central element of the Bhagavad-Gita is the discussion of the problems of war and peace, presented through the dialog between Prince Arjuna and the god Krishna on the battlefield of Kurukshetra. The authors of the article …

Study Of Religious Experience Using The Introspection Method: Case Of Estonia, Siim Nigulas, Tõnu Lehtsaar

Occasional Papers on Religion in Eastern Europe

This article revisits the method of introspection as a valuable tool for studying religious experience in Estonia, where spirituality is often personal, unaffiliated, and deeply introspective. Drawing on the legacy of the Dorpat school—particularly Karl Girgensohn—it highlights how experimental introspection can illuminate the dimensions of faith. Considering Estonia’s post-Soviet religious individualization, the method offers a culturally fitting and academically rigorous approach. The study argues for the revival and adaptation of introspective techniques to explore the inner dynamics of belief in a secular yet spiritually curious society.

Characterization And Drug Release Evaluation Of Chlorhexidine-Encapsulated Silica Nanoparticles For Potential Root Canal Disinfection, Widya Rakhmawati, Andrie Harmaji, Fanni Kusuma Djati, Bambang Sunendar

Makara Journal of Science

The failure of root canal treatments is often attributed to bacterial invasion of the dentinal tubules, where pathogens can persist and complicate healing. Chlorhexidine digluconate, a potent antimicrobial agent, has been widely utilized for its broad-spectrum antibacterial effects. However, challenges remain in achieving efficient distribution and sustained release within the root canal system. This study investigates the encapsulation of chlorhexidine digluconate within silica nanoparticles as a novel drug delivery system that is aimed at improving root canal treatment outcomes. Silica nanoparticles were synthesized using the sol-gel method and subsequently immersed in a 2% chlorhexidine digluconate solution for 15 to 30 …

Effect Of Mercury Dose Variation On Growth And Nitrate Reductase Activity In Aquarius Palifolius (Nees & Mart.) Christenh. & Byng, Tsurayya Nurhanifah, Dwi Umi Siswanti

Makara Journal of Science

Mercury, a byproduct of mining, can harm the environment. One method to reduce this impact is through phytoremediation. This study used the Mexican sword (Aquarius palifolius), a plant with the potential to absorb and accumulate mercury. The aim of this study was to examine the effect of mercury stress on nitrate reductase activity, which plays a role in plant productivity, and to assess its impact on growth parameters, including plant height growth rate, leaf length, and number of leaves. Three-month-old A. palifolius plants obtained from rice fields in Sleman were treated with mercury at doses of 0, 14, …

Improving Nurse Support For People Having Docetaxel Treatment For Prostate Cancer: An Evidence-Informed Change Project Proposal, Anju Mathew

South West Clinical School Journal

#400WORDS: CHIEF NURSING OFFICER’S RESEARCH FELLOWS EVIDENCE IMPLEMENTATION PROJECTS

How Leadership Behaviours Influence Personalised Patient Care In An Integrated Neighbourhood Team: A Mixed-Method Case Study, Gillian H. Cook

South West Clinical School Journal

No abstract provided.

Cross-Section Study Of Iron Deficiency Anemia In A Group Of Adolescents: Frequency And Contributing Factors, Murtaza Hassan Hadi, Mostafa Abdalla Abdelkareem, Nasser Ghaly Yousif

Muthanna Medical Journal

Background: Iron deficiency anemia (IDA) remains a significant global health concern, particularly among adolescents. This study investigated the prevalence and contributing factors of IDA among adolescents at Al Hussain Teaching Hospital, addressing a critical knowledge gap in the Iraqi healthcare context. Methods: A cross-sectional study was conducted on 77 adolescent patients (ages 12-18 years) from October 01, 2024, to January 30, 2025. Data collection included hemoglobin levels, serum ferritin measurements, dietary iron intake assessment, and socioeconomic status evaluation. Statistical analysis employed descriptive statistics, chi-square tests for categorical variables, and multivariate analysis to identify contributing factors. Results: The …

Isolation, Screening And Phenotypic Identification Of Some Medical Important Fungi From Clinical And Various Environmental Sources, Zainab Sahib A. Quraish

Muthanna Medical Journal

Fungi have a major health problem especially dermatophytes for their ability to attack the keratinized tissue of humans such as skin and their accessory (nails and hair). This study aimed to isolate the fungi from clinical and various environmental site. A total of 58 samples, involve 38 samples clinical infections from patients at Women's & Children's Hospital and Al-Hussein Teaching Hospital in the city of Samawah, while 20 samples include various environmental samples. After collection, the samples were transferred to the laboratory for screening via KOH (10%) and identification depending on phenotypic identification and microscopical examination after using lacto-phenol cotton …

Mono And Polymicrobial Biofilm Formation By Candida Species And Staphylococcus Aureus, Ghadeer Ali Saad, Mohammad Hashim Al-Yasiri

Muthanna Medical Journal

Polymicrobial biofilms, composed of fungi and bacteria such as Candida and Staphylococcus aureus, exhibit interactions dependent on environmental factors and organism type. The objective of this investigation was to evaluate the ability of S. aureus and Candida species to construct mono and polymicrobial biofilms. Candida species and S. aureus were isolated from various clinical sources. The identification of these isolates was based on morphological and biochemical characteristics as well as using Vitek 2 compact. Biofilm formation was evaluated using flat-bottom microtiter plate assay with crystal violet. A total of 41 S. aureus, 15 C. tropicalis, 14 C. …

Adaptive Control Of Air Purification Processes In Industrial Painting Workshops: A Review Of Scientific Literature, N.A Kabulov, Sh. Mamatbekov

Chemical Technology, Control and Management

This article examines modern approaches to adaptive control of air purification processes in industrial facilities, particularly in paint shops for parts coating. The relevance of the study is driven by the need to enhance air purification efficiency, ensure worker safety, and comply with environmental regulations. The paper analyzes adaptive control methods, including the use of neural networks, machine learning, and adaptive control algorithms, which enable real-time optimization of purification systems. Special attention is given to the utilization of sensor data for predicting pollution levels and automatically adjusting purification parameters. The article also discusses the advantages and limitations of implementing adaptive …

Development Of An Ann-Based Predictive Model For The Efficient Treatment Of Industrial Wastewater, Alisher Khudoyberdi Ugli Rakhimov, Hasan Siddiq Ugli Murodov, Farrukh Bakhtiyorovich Igitov, Shuhrat Ahmadjonovich Mutalov, Jaloliddin Abdurazzakovich Eshbobaev

Chemical Technology, Control and Management

The effective removal of free chlorine ions from industrial wastewater is critical to ensure process safety, minimize equipment corrosion, and protect aquatic environments. In this study, a laboratory-scale activated carbon filtration system was developed and tested to treat chlorine-contaminated water collected from sludge collectors at industrial facilities. A total of 200 experimental trials were conducted under varied operational conditions, including changes in flow rate, initial chlorine concentration, pressure, pH, temperature, and activated carbon dosage. The resulting dataset was used to train a predictive model based on a feedforward backpropagation artificial neural network (ANN) implemented in MATLAB. The ANN model demonstrated …

The Impact Of Cost Leadership On Financial Distress Mediated Environmental, Social, And Governance, Steven Asher, Meythi Meythi, Riki Martusa, Rapina Rapina

Jurnal Akuntansi dan Keuangan Indonesia

Background: This study investigates the mediating role of environmental, social, and governance (ESG) performance in the relationship between cost leadership and financial distress among companies in Indonesia. Methods: Using path analysis, the research analyzed a sample of 43 firms listed on the Indonesia Stock Exchange from 2018 to 2022. Findings: The findings indicate that cost leadership positively affected ESG; however, no direct relationship was observed between cost leadership or ESG and financial distress. The mediation analysis reveals that ESG acted as a mediator, linking cost leadership to a reduced risk of financial distress. Conclusion: These results highlight the importance of …

Obesity And Smoking Status: Relationships With Specific Pulmonary Functions In University Of Babylon College Of Pharmacy Students, Safa W. Aziz

Muthanna Medical Journal

Adult pulmonary function impairment is associated with both smoking and obesity, albeit the consequences vary from person to person. This study aims to evaluate the relationship between smoking and obesity and their relationship to specific pulmonary functions in a selected group of the population (University of Babylon College of Pharmacy students, Iraq). Materials and Methods: The observational study was carried out on 90 male students at the college pharmacy in the University of Babylon, Iraq. Students enrolled in this study were aged between 19-23 years. The control group (30 males) from general students in the college pharmacy without smoking, …

The Frequency Of Hla-Dr4/Dr4 Type And Interleukin-35 Level Among Type 1 Diabetes Mellitus Patients In Al-Muthanna Governorate/Iraq, Salam Allawi Hassan, Orass Madhi Shaheed

Muthanna Medical Journal

Background: The autoimmune illness recognized as (T1DM) causes weight loss, polyuria, polydipsia, and hyperglycemia along with the progressive death of β-cells. The disease primarily affects children and adolescents. The HLA genes might production a significant part in predisposing to type 1 diabetes. Interleukin-35 as a fellow of the IL-12 family that affects of immune modulation in a number of diseases, for instance (T1D), inflammatory bowel illness, Graves' illness, rheumatoid arthritis. Aim of Study: This study aimed to investigate the frequency of HLA-DR4/DR4 type in type 1 diabetes (T1D) and evaluate of interleukin-35 Level in patients compared with healthy …

Therapeutic Potential Of Bone Marrow-Derived Stem Cells In The Treatment Of Ewing Sarcoma: New Approach, Nasser Ghaly Yousif, Fadhil G. Alamran, Ahmed Altimimi

Muthanna Medical Journal

Background: Ewing Sarcoma is a challenging pediatric bone cancer with limited treatment options, particularly in advanced stages. Recent research has highlighted the potential of bone marrow-derived stem cells (BMSCs) as a novel therapeutic approach due to their tumor-targeting capabilities and ability to modulate the tumor microenvironment. Objective: This study aims to explore the therapeutic potential of BMSCs in the treatment of Ewing Sarcoma, focusing on innovative strategies that leverage their unique properties to enhance treatment efficacy and patient outcomes. Methods: This study involved a comprehensive review of the literature on BMSCs and their application in cancer therapy, …

Gene Profiling And Clinicopathological Features For Prognostic Modeling Of Recurrence In Non-Metastatic Clear-Cell Renal Cell Carcinoma., Xuzhi Yan, Jian Chen, Dianzheng Zhang, Xiaodu Xie, Ziqian Wang, Chongliang Zheng, Junhao Jin, Jing Xu, Qian Yan, Qiuli Liu, Weihua Lan, Jun Jiang

PCOM Scholarly Works

BACKGROUND: Accurate risk stratification of renal cell carcinoma (RCC) is critical for selecting the most appropriate treatment options. Existing prognostic systems, which incorporate various clinical and pathological parameters, have limitations in terms of accuracy. However, it remains unclear whether integrating molecular data with clinicopathological features can enhance the identification of high-risk tumors. The objective of this study was to establish a model to predict RCC recurrence by integrating molecular data with clinicopathological features and to evaluate circulating tumor DNA (ctDNA) as a non-invasive prognostic marker.

METHODS: Next-generation sequencing (NGS) was performed on 73 RCC patients, including 54 with clear-cell RCC …

Data Protection’S Function In Society: A Search For The Limits Of A Non-Absolute Right, Katherine Nolan

Research Outputs: 2025-Present

No abstract provided.

Re: Butte Mine Flooding Operable Unit Berkeley Pit And Discharge Pilot Project – May 2025 Monthly Discharge Monitoring Report, Mark Thompson, Dave Griffis

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Breaking Barriers Exploring Guardianship & Public Administration Challenges Facing Egyptian Widows, Caroline Maher

Theses and Dissertations

This thesis examines the influence of guardianship policies and the administrative infrastructure on the well-being of widows' families in Egypt. Widows in Egypt encounter significant challenges in exercising their guardianship rights due to patriarchal norms, bureaucratic hurdles, inefficient systems, and limited access to information. These obstacles can negatively impact their children's well-being, as well as economic and social stability. Despite social media activism, calls for administrative reforms, and legislative debates, no changes have occurred. This study aims to conduct in-depth exploratory qualitative research to analyze the challenges and limitations of current guardianship policies and administrative systems affecting widows’ families in …

Knowledge Of Hiv Transmission And Prevention Among University Students In Pakistan: A Cross-Sectional Study, Muhammad Saleem, Sajid Masood, Shahid Hussain

Journal of Bioresource Management

HIV/AIDS remains a significant public health problem internationally, with young adults being especially at risk because of behavioral and knowledge deficits. In Pakistan, cultural inhibitions and suboptimal health education are the main reasons for limited awareness, particularly among university students. This study had the objectives of determining the knowledge level about HIV transmission and prevention among undergraduate students in Kohsar University Murree (KUM) and to investigate correlations with salient demographic variables. A cross-sectional survey was carried out among 510 students aged 18-27 years through a pre-validated, standardized questionnaire with 12 knowledge-based items. Descriptive statistics and Chi-square tests were utilized to …

"I Have A Very Particular Set Of Skills": Special Cataloging Approaches For Special Collections., Sasha Frizzell, Erin Labove, Natasha Zaleski

Library Scholarship

Cataloging special collections materials requires specialized training that is not always readily available to catalogers. This presentation will explain the workflows and resources used by three different librarians to catalog materials with unique challenges: community cookbooks, government documents, and archival scrapbooks. Participants will gain the knowledge and confidence to catalog niche material types as this presentation introduces specialized MARC fields, databases, websites, controlled vocabularies, and descriptive standards to use as part of their cataloging toolkit.

The Epilepsy Centers Of Excellence At The Veterans Health Administration, Zulfi Haneef, Caleb A Casanova, Vincent Zhang, Jennifer R Bonds King, Rizwana Rehman, Nina I Garga, Glenn D Graham, Alan R Towne

Faculty, Staff and Students Publications

Introduction: The Veterans Health Administration (VHA) Epilepsy Centers of Excellence (ECoE) was established in 2008 to provide specialized care for veterans with epilepsy. Although established more than a decade ago, there has been no systematic evaluation of the ECoE's performance in key mission areas. We evaluated their performance in several key mission areas-clinical care, research, education, and outreach-since inception to evaluate their success in meeting the initial mandate.

Materials and methods: We analyzed available data from relevant literature, ECoE annual reports, and the ECoE website between 2011 and 2023. Clinical care is the primary mission of the ECoE and was …

Artificial Intelligence In Higher Education: A Case Study Of Faculty Teaching Methodologies At A Private University, Ellen Ramsey, George Antoniou, Matteo Peroni, Brent Muckridge, Raouf Ghattas, Philip L. Fazio, Wendy Wallberg, Saidi Porta, Gary Solomon, Mary Smith, Kristen Migliano, Karima Lanfranco, Lianfen Qian, David G. Wolf

Faculty and Staff Publications & Presentations

This qualitative case study investigates faculty perspectives on artificial intelligence (AI) integration within a private university context, examining pedagogical, administrative, and ethical implications. Data collected through semi-structured interviews with faculty across four disciplines revealed ambivalent yet cautiously optimistic attitudes. Participants acknowledged AI’s potential to enhance personalized learning and reduce bureaucratic burdens through automation. However, three critical barriers emerged: (1) insufficient institutional technological infrastructure, (2) lack of systematic faculty training programs, and (3) unresolved ethical dilemmas surrounding data privacy, algorithmic bias, and academic integrity. Notably, while faculty welcomed AI as a supplemental tool, they unanimously emphasized the irreplaceable role of human …