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Pacific Rxtracts - July 2025, Pacific Rxtracts

Pacific RxTracts

Articles:

• First Blood Test Approved For the Diagnosis of Alzheimer’s Disease
• Rare Withdrawal Reaction Prompts Label Update for Common Antihistamines
• FDA Approves SUSVIMO: Shifting Diabetic Retinopathy Treatment from Monthly Injections to Continuous Therapy
• Battle Against Resistant Hypertension
• Two Is Better than One: Obicetrapib and Ezetimibe, a Novel Combination Pill for High Cholesterol
• Histo-blood Group ABO System Transferase and Venous Thromboembolism Risk
• GLP-1 Agonists and Thiazolidinedione Combination Therapy in Type 2 Diabetes
• Dual Pathway Targeting in Type 2 Diabetes: Exploring the Synergy of GLP1- RAs and SGLT2-inhibitors
• Two Vaccines, One Shot: Combined Immunizations Against COVID-19 and Influenza
• Mirikizumab: A New Frontier …

Pragmatic Approaches To Data Breach Prevention: Strategies Employed By It Managers, Thompson Adefemi Olatuyi

Walden Dissertations and Doctoral Studies

The increasing frequency and complexity of data breaches present critical challenges for cybersecurity managers responsible for protecting organizational assets. This qualitative phenomenological study examined how information technology (IT) managers conceptualize, strategize, and apply best practices to prevent breaches in complex environments. Unmanaged risks can compromise sensitive systems, disrupt operations, and erode stakeholder trust. Business and IT leaders must proactively address these threats to avoid reputational damage, financial loss, regulatory penalties, and loss of competitive advantage. Grounded in Actor-Network Theory (ANT), the study examined insights gathered from 20 experienced IT managers in multiple countries, using semi-structured questionnaires and organizational documents. Thematic …

Administrator Perspectives Of Challenges In Instructional Support Of Secondary Special Education Co-Teach Model, Sonya R. Pichon

Walden Dissertations and Doctoral Studies

The problem addressed in this study was that school administrators may not be knowledgeable regarding how to support co-teachers, which may contribute to the underperformance of students in special education co-teach programs. The purpose of this basic qualitative study was to explore school administrator perspectives regarding the supervision of special education teachers and the support they provide to them in the classroom. This study was grounded in Bass’ transformational leadership. Data were collected through semistructured interviews with 12 secondary school principals and assistant principals who supervise special education programs in one large urban district in Texas serving 22,600 students from …

Single-Level Anterior Cervical Discectomy And Fusion Is Associated With Higher Nonroutine Discharge Rates Compared To Cervical Disc Arthroplasty In Obese Patients, Paul G. Mastrokostas, Luke B. Schwartz, Eli Berglas, Aaron B. Lavi, Leonidas E. Mastrokostas, Jonathan Dalton, Christopher K. Kepler, Arya Varthi, Jad Bou Monsef, Afshin E. Razi, Mitchell K. Ng

Rothman Institute Papers

CONTEXT: Obesity is a recognized risk factor for adverse outcomes in cervical spine surgery. While cervical disc arthroplasty (CDA) has emerged as an alternative to anterior cervical discectomy and fusion (ACDF), comparative outcomes among obese patients remain underexplored.

AIMS: The aim of this study is to compare nonroutine discharge rates and other postoperative outcomes between obese patients undergoing single-level ACDF and CDA.

SETTINGS AND DESIGN: Retrospective cohort study using a national database.

SUBJECTS AND METHODS: The National Inpatient Sample was queried to identify obese patients who underwent single-level ACDF or CDA between 2016 and 2020. Inclusion and exclusion criteria were …

Jamaican Blue Mountain Coffee Farmers’ Effective Strategies For Achieving Profitability, Norman Washington Grant

Walden Dissertations and Doctoral Studies

Jamaican Blue Mountain (JBM) coffee farmers often fail to improve production, which has the potential for adverse business outcomes. Farmers and business owners are concerned about the sustainability of their farm operations, which is essential for achieving profitability. Grounded in Hawley’s risk theory of profit, the purpose of this qualitative multiple case study was to identify and explore effective strategies that JBM coffee farmers used to achieve profitability. The participants were six JBM coffee farm owners in the Jamaican coffee industry who used effective strategies to achieve profitability. Data were collected using semistructured interviews and a review of organizational marketing …

Examining The Association Between The Timing Of The First Antenatal Check; Number Of Antenatal Care (Anc) Visits During Pregnancy With Maternal Mortality In Nigeria, Kanayo Omonoju

Walden Dissertations and Doctoral Studies

Maternal mortality is growing at an alarming rate in Nigeria, ranking the second highest Maternal Mortality Rate (MMR) globally. This cross-sectional study examined the association between the timing of the first antenatal check and the number of Antenatal Care (ANC) visits during pregnancy and its impact on maternal mortality using the Nigerian Demographic and Health Survey (NDHS) 2018 among a study population of women 15 - 49 years old. The theoretical framework for this study was grounded in the socioecological model. Multiple logistic regression was used to determine if there are relationships between timing of first antenatal check, the number …

The Association Between Dietary Behavior Change And The Health Of Adult African Immigrants In The United States, Seyoum Abebe

Walden Dissertations and Doctoral Studies

African immigrants represent one of the fastest-growing immigrant populations in the United States; yet, their health outcomes related to Type II diabetes remain understudied compared to other racial and ethnic groups. Grounded in the theoretical framework of the Health Belief Model, the purpose of this quantitative non-experimental study was to examine the relationship between dietary behavior changes and the diagnosis of Type 2 diabetes among African immigrants aged 20–80 residing in the United States. The research questions examined the association between getting meals prepared away from home and awareness of MyPlate nutritional guidelines, recommended by the U.S. Department of Agriculture, …

Using Web Scraping As A Tool To Collect School Nutrition Data, Aaron Brown

Student Works

Web scraping, a technique for collecting publicly available online data, may facilitate collecting school meal data from large, national samples of school districts in a timely, cost-effective manner. We explore its potential by examining the variation in sodium content of 2 popular entrees served through the US Department of Agriculture’s National School Lunch Program—pizza and chicken nuggets. Daily school menu data were obtained from a national sample of school districts via web scraping. Linking web scraped data to publicly available data on school districts permitted examination of entree sodium content variation across school district geographic and socioeconomic characteristics. Such …

Our Ethical Duty: Assessing The Competencies Of Counselors-In-Training For Counseling With Transgender And Gender Expansive Clients, Deanna N. Cor, M. N. Saltis, Megan Doughty Shaine, Lauren Streeter

Counselor Education Faculty Publications and Presentations

Counselors report a lack of competence in working with transgender and gender expansive (TGE) individuals. TGE people report a lack of competent and affirming care. This study used the Gender Identity Counselor Competency Scale- Revised (GICCS-R) to understand self-reported competence and training levels in working with this population. Participants were 90 masters-level counselors in training who had at least started practicum in CACREP-accredited programs. Hierarchical linear regression was utilized to determine factors that predict competence including identities and training levels. Results highlight a lack of perceived competence in skill-based training. Counselor education programs must focus on improving TGE affirmative skills.

Re: Approval Letter For Butte Priority Soils Operable Unit (Bpsou) Draft Final 2024 Subdrain Data Summary Report (Dated April 30, 2025), Emma Rott

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Introduction To Sociology: The Family, Dr. Marcia Morrison Ph.D.

Open Educational Resources

Abstract

This paper explores the evolving landscape of modern family structures, analyzing their diverse forms, core functions, and the challenges they face within contemporary society. Drawing on recent research and theoretical frameworks, it examines the transformation of parenthood—especially single fatherhood—the shifting definitions of family and kinship, and the influence of family structure on emotional security, socialization, and reproductive roles. The discussion highlights the rise of dual-career households, increased grandparental involvement, the complexities of blended and single-parent families, as well as the growing acceptance of cohabitation and child-free couples. Special attention is given to persistent social problems, such as the cycles …

Introduction To Sociology: Culture, Dr. Marcia Morrison Ph.D.

Open Educational Resources

Abstract

A Synthesis of Sociological Perspectives on Culture and Social Evolution This paper provides an in-depth exploration of culture as a foundational element in the study of sociology, dissecting its central components—knowledge, language, symbols, values, norms, and material objects—and their profound impact on society. Through the examination of cultural integration and diversity, the analysis foregrounds the dynamic tensions between assimilation and the preservation of subcultures, illustrating how these forces shape identities, relationships, and social cohesion in contemporary contexts. The discussion offers nuanced insights into the processes by which dominant and minority cultures interact, negotiate power, and navigate the challenges of …

Quantum Magnetization Exchange Through Transient Hydrogen Bond Matrix Defines Magnetic Resonance Signal Relaxation And Anisotropy In Central Nervous System, Dmitriy A Yablonskiy, Alexander L Sukstanskii

2020-Current year OA Pubs

The integrity of cellular membranes (lipid bilayers) and myelin sheaths covering axons is a crucial feature controlling normal brain structural and functional networks. Yet, in vivo evaluation of this integrity at the nanoscale level of the cellular membranes organization is challenging. Herein we explore the dual property of biological water in Central Nervous System (CNS), as one of the major stabilizing factors of cellular membranes, and the major source of MRI signal. We introduce the Basic Transient Hydrogen Bond (THB) model of the MR signal relaxation due to the quantum spin/magnetization exchanges within the THB Matrix encompassing water molecules and …

Atrial Fibrillation Or Flutter In Patients Undergoing Stem Cell Transplantation, In-Hospital And Post-Discharge Outcomes In A Large Nationwide Sample Across The United States, Raja Zaghlol, Elena Deych, Nina Manian, Ahmed Altibi, Joshua D Mitchell

2020-Current year OA Pubs

BACKGROUND: Stem Cell Transplantation (SCT) is a cornerstone therapy in managing several malignant and benign hematological conditions. Atrial fibrillation/atrial flutter (AF) are commonly encountered in patients receiving SCT. There is a paucity of large-scale data on the prevalence of AF and their effect on outcomes following SCT.

METHODS: The United States National Readmission Database (NRD) was used to identify hospitalized patients who underwent SCT. Baseline demographics, comorbidities, the presence or absence of AF, the indication, and type of SCT were identified using diagnostic and procedural International Classification of Diseases 10th Edition (ICD-10) codes. Patients with AF were compared to those …

The Trapping Of Live Neutrophils By Macrophages During Infection, Kelley N Cooper, Marina Terekhova, Barbara Potempa, Ana D'Aubeterre, Jerome Timbol, Si An Chen, Antoine Dufour, Shunying Jin, Maxim N Artyomov, Jan Potempa, Juhi Bagaitkar

2020-Current year OA Pubs

Neutrophils are highly abundant in the oral mucosal tissues, and their balanced activation and clearance are essential for immune homeostasis. Here, we demonstrate that neutrophils infected with the bacterial pathogen Porphyromonas gingivalis (Pg) are captured alive by macrophages in a manner that bypasses all known receptor-ligand interactions involved in the phagocytosis of either live or dead cells. Mechanistically, upon interaction with Pg, or its protease RgpB (gingipains), live neutrophils undergo rapid remodeling of their proteomes, generating neoepitopes. N-terminomics-based proteomic profiling identified multiple RgpB cleavage sites on several azurophilic granule proteins that are translocated to the surface of live neutrophils via …

Atrial Fibrillation Is Associated With Increased In-Hospitality Mortality During Chimeric Antigen Receptor T-Cell Therapy Hospitalizations: A Retrospective Cohort Study In The United States, Nischit Baral, Nabin R Karki, Daniel A Ladin, Raja Zaghlol, Mahmoud Ibrahim, Alexander Rabadi, Tarec K Elajami, Olivia Mechanic, Arvind Kunadi, Joshua D Mitchell

2020-Current year OA Pubs

BACKGROUND: Chimeric Antigen Receptor (CAR) T-cell therapy (CAR-T) has emerged as a promising treatment for specific hematological malignancies. While some studies suggest an association between CAR-T and atrial fibrillation (AF), more data are needed on the association of AF with CAR-T outcomes.

METHODS: This retrospective cohort study utilized the National Inpatient Sample (NIS) 2017-2020 to explore in-hospital outcomes in cancer patients with AF while undergoing CAR-T. Comparisons were drawn between patients with and without AF during the hospitalization, assessing various parameters including mortality rates, length of hospital stay, and occurrences of acute heart failure, pulmonary edema, and gastrointestinal (GI) bleeding. …

Introduction To Sociology: Class And Stratification, Dr. Marcia Morrison Ph.D.

Open Educational Resources

Abstract

This paper explores the intricate dynamics of class, stratification, and social inequality, emphasizing the interplay of wealth, power, and prestige in shaping individual opportunities and societal outcomes. Drawing on foundational theories from Marxist and functionalist perspectives, it examines the mechanisms by which economic and social structures reinforce or challenge class divisions. The analysis extends to the evolution of American economic disparity, particularly during the transformative 1980s, and examines policies aimed at addressing poverty, such as those articulated by Sar Levitan and the implementation of the Social Security Act. Through a nuanced discussion of cultural capital, the role of …

Collaborative Strategies In Self-Protection Against Sexual Violence For Children With Intellectual Disabilities: Systematic Literature Review, Zulfa Rahmah Effendi, Endang Rochyadi, Budi Susetyo, Oom Sitti Homdijah

Journal of ICSAR

This study explores collaborative strategies based on the Pentahelix model to enhance self-protection education against sexual violence for children with intellectual disabilities. Recognizing the heightened vulnerability of this population and the fragmented nature of existing protective mechanisms, this research adopts a Systematic Literature Review (SLR) method guided by PRISMA protocols. A total of 25 peer-reviewed, Scopus-indexed articles published between 2015 and 2024 were thematically analyzed. The findings reveal that multi-actor collaboration involving government, academia, communities, the private sector, and media plays a pivotal role in establishing responsive protection systems and educational interventions tailored to the specific needs of children with …

Guidance & Counseling Services For Students Special Needs In The Organizer School Inclusive Education In Dki Jakarta Region, Marja Marja, Trisna Mulyeni, Irah Kasirah, Widia Kusuma Dewi

Journal of ICSAR

This study examines the implementation of guidance and counseling (BK) services for students with special needs (ABK) in inclusive public schools in the DKI Jakarta region. Although inclusive education policies have been adopted nationally, the provision of structured psychosocial and academic support through counseling remains inconsistent across schools. Using a qualitative descriptive approach, this research involved twelve inclusive schools and collected data through interviews, observations, and document analysis. Participants included BK teachers, homeroom teachers, and school principals. Thematic analysis was conducted to identify patterns in the design, delivery, and impact of counseling services for ABK students. The findings indicate that …

The Influence Of Learning Communities, Work Ethic, And Achievement Motivation On Teacher Professional Competence: A Quantitative Study In Public Elementary Schools In Candisari District, Semarang City, Fina Febriyanti, Maryanto Maryanto, Ngasbun Egar

Journal of ICSAR

One of the key determinants of educational quality is the professional competence of teachers, which directly impacts student achievement and the overall standard of education. This study examines the influence of learning communities, work ethic, and achievement motivation on the professional competence of elementary school teachers in Candisari District, Semarang. Recent performance evaluations indicate that teachers’ professional competence remains lower than other competencies, highlighting the need for targeted improvement. Learning communities serve as collaborative platforms for teachers to share experiences and solve instructional challenges, especially relevant with the implementation of the Merdeka Curriculum, which demands greater flexibility and student-centered approaches. …

Analysis Of Student Learning Experiences In Sign Language Learning Through A Deep Learning Approach Based On The Case-Based Learning Model, Imas Diana Aprilia, Prinanda Gustarina Ridwan, Lamina Amalia Putri, Indah Auliya Muchtar

Journal of ICSAR

Students in special education programs often face challenges in mastering sign language due to limited access to interactive and contextual learning experiences. Therefore, this study aimed to explore the implementation of sign language learning by integrating the Deep Learning approach, which emphasizes mindful, meaningful, and joyful learning, with the Case-Based Learning (CBL) model to provide a more holistic learning experience. Using a descriptive research design with a qualitative approach supported by quantitative data, the study involved 51 students who had completed a sign language course and one instructor from the Special Education Study Program. Data were collected through observation, semi-structured …

Assessing Significance Of Inclusive Education As A Remedy Of Addressing The Challenges Of Disabled Children, Sive Makeleni, Onyinyechi Glory Ndu

Journal of ICSAR

The issue of disability in the lives of many children has raised a lot of debates by scholars in terms of their learning ability and meeting immediate needs. This study focuses on the inclusive education for dealing with special needs of children. It aimed at assessing the significance of inclusive education and training as a remedy for addressing the challenges facing the disabled children in dealing with their special needs. What their immediate needs are, and finally suggest measures to put in place in addressing the identified problems. The study employed a literature review method. The data was collected using …

Brivaracetam Effectiveness And Patient-Reported Outcomes In Clinical Practice: Data From A 12-Month Prospective, Observational Study In The United States., Hina Dave, Michael R. Sperling, Hamada Hamid Altalib, Heidi Henninger, Roger J. Porter, Michael Gelfand, Prashant Dongre, Sami Elmoufti, Melinda S. Martin, Anne-Liv Schulz, Jacqueline A. French

Department of Neurology Faculty Papers

OBJECTIVE: Evaluate real-world effectiveness, patient-reported outcomes (PROs), and safety/tolerability of brivaracetam in patients (≥16 years) with focal-onset seizures currently receiving ≥ 1 antiseizure medication (ASM), and with historical or current use of levetiracetam, lamotrigine, oxcarbazepine, and/or carbamazepine.

METHODS: EP0088 was a 12-month, prospective, observational study of brivaracetam in a clinical practice setting in the US. Primary study outcome was brivaracetam retention at 12 months after brivaracetam initiation. Effect of brivaracetam on patients' perceptions of their health was assessed using Patient-Reported Outcomes Measurement Information System (PROMIS) short forms and Seizure-Related Disability Assessment Scale (SERDAS). Safety outcomes included incidence of treatment-emergent adverse …

How Are We Defining Preoperative Anemia? A Comparison Of Various Anemia Thresholds Among Patients Undergoing Short-Construct Lumbar Spinal Fusion, Tariq Issa, Omar Tarawneh, Teeto Ezeonu, Mark Lambrechts, Mark Kurd, Ian Kaye, Jose Canseco, Alan Hilibrand, Alex Vaccaro, Christopher Kepler, Gregory Schroeder

Department of Orthopaedic Surgery Faculty Papers

BACKGROUND: Anemia is a risk factor for increased transfusions. However, various definitions of anemia have been described in scientific literature and a consensus on how to appropriately diagnose anemia or who to preoperatively optimize is lacking. We aimed to compare multiple anemia definitions and evaluate if any threshold best predicts transfusion requirements and surgical outcomes following spinal fusion.

METHODS: We conducted a retrospective cohort study of 1-2 level posterior spinal fusions. Preoperative hemoglobin was defined based on preoperative laboratories within 28 days of surgery. Anemia was diagnosed using the World Health Organization (WHO), the American Society of Hematology (ASH), and …

Extrusion Process Optimization Of Sea Red Rice And Its Physicochemical Properties , Digestion Characteristics , And Nutritional Components, Sun Wufei, Wang Zhuo, Zhong Saiyi, Zou Wentao, Hu Jiakang

Food and Machinery

［Objective］ To investigate the effects of extrusion technology on the physicochemical properties,digestion characteristics,and nutritional components of sea red rice.［Methods］ The extrusion process parameters for sea red rice are optimized by response surface methodology.The effects of the extrusion treatment on the physicochemical properties of the sea red rice flour are explored by water solubility index (WSI ),gelatinization degree,starch digestion properties (including rapidly digestible starch,slowly digestible starch,and resistant starch ),and the anti -nutritional factor content (phytic acid ).The microstructure,starch crystal form,and crystallinity are 钟赛意（1979—），男，广东海洋大学教授，博士。E-mail：zsylxc@ 126.com引用格式：孙武飞，汪卓，钟赛意，等.海红米挤压工艺优化及理化性质、消化与营养特性研究 ［J］.食品与机械，2025，41（6）：164-172.C itation:SUN Wufei,WANG Zhuo,ZHONG Saiyi,et al.Extrusion process optimization of sea red rice and its physicochemical properties,digestion characteristics,and …

A Case Study In Evolving Academic Governance: Democratic Accountability And Academic Capitalism, William C. Schulz, Denise Dezolt

Higher Learning Research Communications

As the higher education market becomes both more competitive and fragmented (as well as controlled through uncertain and changing regulatory regimes), and as those whom the higher education market serves become more discerning as consumers who apply proven customer behaviors within the market, universities must re-evaluate their internal governance systems. Re-evaluation of customer behaviors and governance systems may allow universities to become more inclusive, responsive, and adaptive within an academic capitalism setting.

In this case study, we present a research-based and integrated “Shared, Informed, Stakeholder-Engaged Governance” model. We describe how a large online university developed and implemented a model that …

Wendy Kooken, Wendy Kooken, Nathalie Romero '25, Posse Legacy Project, Illinois Wesleyan University

All oral histories

Interview of Wendy Kooken, PhD, RN on July 3, 2025. Wendy Kooken, PhD, RN, Posse 4 and Posse 7 mentor and Associate Professor of Nursing at Illinois Wesleyan University.

Synthesis And Evaluation Of Novobiocin Analogues As Potential Inhibitors Of Polymerase Theta Polθ In Dna Damage And Repair, Mohammed Essam Albuhluli

Theses and Dissertations

Killing tumors while leaving normal cells unharmed is the goal of precision cancer therapy, a challenging feat that is enabled by targeting tumor-specific vulnerabilities [1]. Targeting Polθ potentiates PARP inhibitors (PARPi) in specifically killing homology-directed repair (HDR)-deficient tumor cells and re-sensitize PARPi resistant tumor cells [1]. The induced essentiality between Polθ and HDR-deficiency underscores the value of Polθ as a therapeutic target in the context of tumors with HDR genetic mutations [1]. The helicase-like domain (HLD) is a super family 2 (SF2)-type domain with DNA-dependent ATPase activity [1]. We previously discovered that the antibiotic NVB acts as an inhibitor of …

The Impact Of Operative Level On Patient-Reported Outcome Measures Following Single-Level Posterior Lumbar Decompression For Disc Herniation, Jonathan Dalton, Robert Oris, Omar Tarawneh, Gregory Toci, Rajkishen Narayanan, Dominic Finan, Hannah Bash, Marco Goldberg, John Mangan, Barrett Woods, Mark Kurd, Ian Kaye, Jose Canseco, Alan Hilibrand, Alex Vaccaro, Gregory Schroeder, Christopher Kepler

Department of Orthopaedic Surgery Faculty Papers

OBJECTIVE: To compare the impact of upper versus lower lumbar decompression on patient-reported outcome measures (PROMs).

MATERIALS AND METHODS: Patients undergoing L1-L2, L2-L3, L4-L5, or L5-S1 single-level elective decompression with 1-year PROMs were identified. Included PROMs were the Oswestry Disability Index (ODI), visual analog scale (VAS) back and leg, and Short Form-12 physical (PCS) and mental (MCS) component scores. Minimal clinically important differences (MCID) were calculated. Multivariable regressions assessed the independent predictive ability of operative level controlling for demographic confounders.

RESULTS: Three hundred and forty-six patients were included (94 upper lumbar decompressions). Upper lumbar decompression patients were older (64.0 vs. …

A Comparison Of Different Posterior Arthrodesis Techniques Versus Anterior Dens Screw For Odontoid Fractures: A Systematic Review And Meta-Analysis, Pavlos Texakalidis, Stavros Matsoukas, Michael Cloney, Mykhaylo Krushelnytskyy, Kevin Swong, Najib El Tecle, Tyler Koski, Nader Dahdaleh

Department of Neurosurgery Faculty Papers

BACKGROUND AND OBJECTIVES: Odontoid fractures are often managed surgically. The most common approaches are anterior dens screw (ADS) and posterior arthrodesis (PA), with the latter being associated with significantly higher fusion rates. PA techniques can include wiring, C1-C2 transarticular (TA) screws, and C1 lateral mass (LM)-C2 pars/pedicle screws. Most comparative studies group multiple PA techniques together when comparing PA versus ADS. Our objective was to systematically review the literature and identify studies that separately provide fusion rates of each different posterior C1-C2 arthrodesis (PA) technique utilized compared to ADS.

METHODS: A systematic literature review was conducted according to the Preferred …