Digital Commons Network^™

Drug Recognition Experts’ Perspectives On The State Of Maryland’S Legalization Of Cannabis And Its Impact On Impaired Driving, Raymond D. Brooks

Walden Dissertations and Doctoral Studies

Motor vehicles have become both affordable and practical to own. As a result, law enforcement has been tasked with enforcing laws related to safe vehicular operation on the roadways nationwide. Further, much like alcohol, drug influence causes concern for motorists, and with the introduction of cannabis legalization, there is a clash between use, public interaction and vehicle operation. Cannabis consumption in public, the perception that use is allowed anywhere, and the impact that impairment has while driving can be a concern for those tasked with enforcing laws that some perceive to be allowed. This study introduces cannabis legalization within the …

Representation And Visualization Of Multivariate Sensory Time Series Data, Ismail Uysal, Alla Abdella

USF Patents

In accordance with some embodiments, systems, methods, and media for processing and representing multivariate sensor information gathered from multiple sources are provided. In some embodiments, the method comprises: receiving a data sequences from respective sources; identifying a shortest data sequence that corresponds to a first interval; calculating, for pairs of data sequences, a similarity value over the first interval; forming a first segment of a representative data sequence that is a weighted combination of the data sequences over the first interval based on similarity values associated with the data sequences; truncating at least a subset of data sequences to exclude …

Violence Towards Ems, Briana Moffat

AJiC Fact Sheets

This factsheet examines violence towards Emergency Medical Services (EMS) responders as documented in existing research literature, tying into Alaska's Crisis Response Team models.

Conniff, Michael L. (1942-2025), San Jose State University

Emeritus and Retired Faculty Biographies

University of California, 1968, BA, Latin American Studies

Stanford University, 1969, MA, Latin American Studies

Stanford University, 1976, Ph.D., History

2025-07-08 Minutes, Morehead State University. Staff Congress.

Staff Congress Records

Staff Congress meeting minutes from July 8, 2025.

Under Pressure: Performance Loads And Recovery In Ncaa Division I Women’S Soccer During Fixture Congestion, Jade X. Dawson, Fabiano T. Amorim

Health, Exercise, and Sports Sciences ETDs

Soccer places high physiological demands on athletes, and match congestion—playing more than two games per week—is a growing concern at the NCAA Division I level. Limited recovery time between matches can impair performance and increase injury risk, prompting widespread use of recovery strategies. However, research on their effectiveness remains inconclusive, and most existing studies focus on male athletes, leaving a gap in evidence specific to female players. This review and observational study aim to evaluate non-nutritional recovery strategies in NCAA Division I women’s soccer and examine how recovery duration influences performance.

Match load data were collected from eleven female athletes …

Relationship Between Indulgent Parenting, Household Composition, And Parental Efficacy In Managing Adolescents' Smartphone Use, Bernice Cook

Walden Dissertations and Doctoral Studies

Smartphones have become an integral part of society, resulting in increased adolescent dependence on smartphone applications. This dependence poses challenges for parents in managing the risk of problematic smartphone use among adolescents aged 11-17 years old. Rapid technological advancements have significantly reshaped parenting practices, necessitating greater adaptability and impacting adolescent development. Guided by Bandura’s self-efficacy theory, this correlational study examines how indulgent parenting and household composition, including demographic variables such as race, gender, education, employment, and income, predict parental self-efficacy in managing adolescent smartphone use. A convenience sample of 238 U.S. parents, with at least one adolescent aged 11-17 years, …

First Quantitative Investigation On The Dosimetric Perturbation From Dental Hardware In Spot-Scanning Proton Arc (Sparc®) Therapy And Planning Strategies In Head Neck Cancer Patient Population, Evan Harbert

Masters Projects

Purpose

There has been a tremendous interest in applying Spot-scanning Proton Arc (SPArc^®) to benefit head and neck cancer (HNC) patient population. However, the dental hardware materials effects on the beam distribution are not well understood, and placing spots through the dental hardware may cause an unnecessary degradation of target coverage if the material components differ from the nominal plan. The purpose of this study is to provide a quantitative dose perturbation analysis of the uncertainties caused by dental hardware and introduce a SPArc^® planning strategy to mitigate such impacts.

Methods and Materials

A published in-house developed …

Distinct Echinocandin Responses Of Candida Albicans And Candida Auris Cell Walls Revealed By Solid-State Nmr, Malitha C. Dickwella Widanage, Kalpana Singh, Jizhou Li, Jayasubba Reddy Yarava, Faith J. Scott, Yifan Xu, Neil A.R. Gow, Frederic Mentink-Vigier, Ping Wang, Frederic Lamoth, Tuo Wang

School of Graduate Studies Faculty Publications

Invasive candidiasis affects 1.6 million people annually, with high mortality among immunocompromised and hospitalized patients. Echinocandins are frontline antifungals, but rising resistance limits their efficacy. Here, we show that Candida albicans and multidrug-resistant Candida auris share a conserved cell wall architecture yet differ markedly in their adaptive responses to echinocandins. Solid-state NMR reveals that both species possess a rigid inner layer of tightly associated chitin microfibrils and β−1,3-glucans, supported by a flexible matrix of β−1,6-glucans and additional β−1,3-glucans. Outer mannan fibrils rely on α−1,2-linked sidechains to maintain contact with the inner wall. In both species, caspofungin rigidifies β−1,6-glucans and mannan …

Polymorphic Α-Glucans As Structural Scaffolds In Cryptococcus Cell Walls For Chitin, Capsule, And Melanin: Insights From 13c And 1h Solid-State Nmr, Ankur Ankur, Jayasubba Reddy Yarava, Isha Gautam, Faith J. Scott, Frederic Mentink-Vigier, Christine Chrissian, Li Xie, Dibakar Roy, Ruth E. Stark, Tamara L. Doering, Ping Wang, Tuo Wang

School of Graduate Studies Faculty Publications

Cryptococcus species are major fungal pathogens responsible for life-threatening infections in approximately a million individuals globally each year, with alarmingly high mortality rates. These fungi are distinguished by a distinctive cell wall architecture further reinforced by two virulence-associated layers, melanin and capsule, rendering them insensitive to antifungal agents targeting the cell wall, such as echinocandins. The molecular interplay between these three biomolecular layers remains poorly understood. Here we employ solid-state NMR spectroscopy to examine intact cells of both wild-type and capsule-deficient strains of C. neoformans, along with melanized cells. High-resolution 13C and 1H data revealed five distinct structural forms of …

Modulation Of Redox-Sensitive Cardiac Ion Channels, Rawan S. Orfali, Al Hassan Gamal El-Din, Varnika Karthik, Elisanjer Lamis, Vanna Xiao, Alena Ramanishka, Abdullah Alwatban, Osama Alkhamees, Ali Alaseem, Young-Woo Nam, Miao Zhang

Pharmacy Faculty Articles and Research

Redox regulation is crucial for the cardiac action potential, coordinating the sodium-driven depolarization, calcium-mediated plateau formation, and potassium-dependent repolarization processes required for proper heart function. Under physiological conditions, low-level reactive oxygen species (ROS), generated by mitochondria and membrane oxidases, adjust ion channel function and support excitation–contraction coupling. However, when ROS accumulate, they modify a variety of important channel proteins in cardiomyocytes, which commonly results in reducing potassium currents, enhancing sodium and calcium influx, and enhancing intracellular calcium release. These redox-driven alterations disrupt the cardiac rhythm, promote after-depolarizations, impair contractile force, and accelerate the development of heart diseases. Experimental models demonstrate …

The Role Of Self-Reported Health Ratings In Identifying Hospitalization Risk Among Older Adults: An Integrated Review And Secondary Analyses Of Medicare Claims Data, Mary B. Prybylo

MUSC Theses and Dissertations

Purpose: This study examined how Self-Reported Health (ratings), a person’s own evaluation of their overall health, relates to hospital admissions and emergency department utilization. It further assessed the extent to which demographic characteristics, Risk Adjustment Factor (RAF) scores (used to estimate healthcare expenditures based on clinical complexity), and the number of chronic conditions influence SRH rating and the likelihood of hospitalization.

Problem and Aim: The growing population of older adults places greater demands on healthcare services, leading to increased financial strain and a need for improved care strategies. Primary care teams, particularly those managing older adults, require effective assessment …

Towards Fair Decentralized Benchmarking Of Healthcare Ai Algorithms With The Federated Tumor Segmentation (Fets) Challenge, Maximilian Zenk, Pamela Lamontagne, Daniel S Marcus, Mikhail Milchenko, Arash Nazeri, Et Al.

2020-Current year OA Pubs

Computational competitions are the standard for benchmarking medical image analysis algorithms, but they typically use small curated test datasets acquired at a few centers, leaving a gap to the reality of diverse multicentric patient data. To this end, the Federated Tumor Segmentation (FeTS) Challenge represents the paradigm for real-world algorithmic performance evaluation. The FeTS challenge is a competition to benchmark (i) federated learning aggregation algorithms and (ii) state-of-the-art segmentation algorithms, across multiple international sites. Weight aggregation and client selection techniques were compared using a multicentric brain tumor dataset in realistic federated learning simulations, yielding benefits for adaptive weight aggregation, and …

Cord Blood Proteomics Identifies Biomarkers Of Early-Onset Neonatal Sepsis, Leena B. Mithal, Mark E. Becker, Ted Ling-Hu, Young Ah Goo, Sebastian Otero, Aspen Kremer, Surya Pandey, Nicola Lancki, Yawei Li, Yuan Luo, William Grobman, Denise Scholtens, Karen K. Mestan, Patrick C. Seed, Judd F. Hultquist

2020-Current year OA Pubs

BACKGROUNDSymptoms of early-onset neonatal sepsis (EOS) in preterm infants are nonspecific and overlap with normal postnatal physiological adaptations and noninfectious pathologies. This clinical uncertainty and the lack of reliable EOS diagnostics results in liberal use of antibiotics in the first days to weeks of life, leading to increased risk of antibiotic-related morbidities in infants who do not have an invasive infection. METHODSTo identify potential biomarkers for EOS in newborn infants, we used unlabeled tandem mass spectrometry proteomics to identify differentially abundant proteins in the umbilical cord blood of infants with and without culture-confirmed EOS. Proteins were then confirmed using immunoassay, …

Acute Effect Of A Multi-Ingredient Pre-Workout Supplement On Pacing And Kinetic Expression During Shorter And Longer Bouts Of High Intensity Functional Training, Gerald Mangine, Christopher Staples, James W. Henley, Ashley Hines, Kristyn C. Mcgeehan, Wysmark Chaves, Wil King, Tiffany A. Esmat, John R. Mclester, Jacob L. Grazer

Faculty Articles

Background: High-intensity functional training (HIFT) varies daily workout programming, and trainees are often tasked with completing “as many repetitions as possible” (AMRAP) within a set time. Successful performance depends on fatigue management skills and maintaining a consistent expression of force and velocity when performing and transitioning between exercises over the duration of the workout. Multi-ingredient preworkout (MIPS) supplement formulations often contain ingredients shown to facilitate energy availability and mitigate fatigue, and therefore, might positively affect HIFT performance. This study aimed to assess a multi-ingredient pre-workout supplement’s acute effect on pacing and the expression of kinetics throughout a 5- and 15-minute …

Nivolumab Plus Relatlimab For Patients With Relapsed Or Progressed B-Cell Malignancies In Relativity-022, Ajay K Gopal, Nancy L Bartlett, Et Al.

2020-Current year OA Pubs

Despite high response rates, anti-programmed death 1 (anti-PD-1) monotherapy eventually fails in most patients with relapsed/refractory (R/R) Hodgkin lymphoma (HL) and is ineffective in most other B-cell malignancies. The lymphocyte activation gene 3 (LAG-3) cell-surface receptor represents another immune checkpoint that can be targeted to induce remissions in these diseases; dual inhibition of PD-1 and LAG-3 is approved in advanced melanoma. We performed a multicenter phase 1/2a open-label study of the anti-LAG-3 antibody relatlimab (RELATIVITY-022) administered as monotherapy or in combination with nivolumab in patients with R/R B-cell malignancies. We treated 106 patients and no dose-limiting toxicities were observed during …

Bridging Radiotherapy Before Chimeric Antigen Receptor T Cells For B-Cell Lymphomas: An Ilrog Multicenter Study, Nikhil Yegya-Raman, Joanna C Yang, Et Al.

2020-Current year OA Pubs

Despite the increasing utilization of bridging radiotherapy (Br-RT), its impact on chimeric antigen receptor T-cell therapy (CAR-T) efficacy and toxicity remains poorly characterized. We retrospectively reviewed patients with relapsed/refractory B-cell lymphomas (BCLs) who received Br-RT followed by CAR-T from 2018 to 2020 across 10 institutions. Br-RT toxicities were graded per Common Terminology Criteria for Adverse Events version 5.0, and cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS) per American Society for Transplantation and Cellular Therapy Consensus Guidelines. One hundred seventy-two patients (168 large BCL) received Br-RT before axicabtagene ciloleucel (73%), tisagenlecleucel (24%), or brexucabtagene autoleucel (2%). At …

Total Synthesis And Biological Activity Of "Carbamorphine": O-To-Ch2 Replacement In The E-Ring Of The Morphine Core Structure, Sota Akiyama, Rohini S Ople, Alexander Kremsmair, Nokomis Ramos-Gonzalez, Thomas Nedungadan, Brandon J Kennedy, Kevin Appourchaux, Shainnel O Eans, Bowen A Tsai, Christina Kraml, Xi-Ping Huang, Jay P Mclaughlin, Susruta Majumdar, Richmond Sarpong

2020-Current year OA Pubs

Morphine is a µ-opioid receptor (MOR) agonist and potent analgesic. However, it displays several side effects including respiratory depression and addiction. Here, we show that a single heavy atom replacement in the morphine core structure (O to CH

Action-Mode Subnetworks For Decision-Making, Action Control, And Feedback, Carolina Badke D'Andrea, Timothy O Laumann, Dillan J Newbold, Charles J Lynch, Mohammad Hadji, Steven M Nelson, Ashley N Nielsen, Roselyne J Chauvin, Samuel R Krimmel, Abraham Z Snyder, Scott Marek, Deanna J Greene, Marcus E Raichle, Nico U F Dosenbach, Evan M Gordon

2020-Current year OA Pubs

The action-mode network (AMN) is a canonical functional brain network first identified using resting-state functional connectivity (RSFC). Based on animal and human data, we have proposed that AMN supports the brain's action mode by controlling functions required for successful goal-directed behavior. However, task fMRI averaged across groups has associated AMN regions with a variety of behaviors, contributing to uncertainty about AMN function. Here, we investigated the AMN using an inside-out approach, in which the network architecture of the AMN is first precisely mapped within individuals and then associated with behavioral functions. Individual-specific precision functional mapping with >5 h of RSFC …

Involvement Of Microglia In Retinal Ganglion Cell Injury Induced By Iop Elevation In A Rat Ex Vivo Acute Glaucoma Model, Taimu Sato, Makoto Ishikawa, Yukitoshi Izumi, Naoya Shibata, Kota Sato, Michiko Ohno-Oishi, Hiroshi Tawarayama, Hiroshi Kunikata, Charles F Zorumski, Toru Nakazawa

2020-Current year OA Pubs

No abstract provided.

Association Of Tumor-Infiltrating Lymphocytes And Inflammation Status With Survival Outcome In Patients With High-Grade Serous Ovarian Carcinoma, Simona Miceska, Cvetka Grašič Kuhar, Snježana Frković Grazio, Erik Škof, Praveen Krishnamoorthy, Dineo Khabele, Veronika Kloboves Prevodnik

2020-Current year OA Pubs

No abstract provided.

Quantifying Impacts Of Microplastic Emissions In Life Cycle Impact Assessment, Maria Elena Corella Puertas

Micro-Nano Plastics in Water: Characterization, Cure and Prevention

Please click Additional Files below to see the full abstract

Livestock Poultry Health Committee Minutes, Clemson University Board Of Trustees, 2025 July 8, Clemson University Board Of Trustees

Minutes

No abstract provided.

Adaptation And Standardization Of Two Arabic Communicative Development Inventories For Children Aged 8 To 30 Months And 30 To 48 Months In Egypt, Jordan And Palestine, Alshaimaa Abdelwahab, Caroline Floccia, Samuel Forbes, Zakiyah Alsiddiqi, Khalid Al-Shdifat, Cristina Mckean, Thair Odeh, Anastasia Trebacz, Ghada Khattab

School of Psychology

PURPOSE: Assessing early language skills through parental report is a cost-effective way to screen for language delays when resources are scarce. A pan-Arabic lexeme approach was tested by extending the Egyptian adaptation of the MacArthur-Bates Communicative Development Inventory (CDI) to Jordan and Palestine in infants aged 8-30 months (Arabic CDI Toddler). We also developed a version for children aged 30-48 months (Arabic CDI Child) in the three countries. A fair representation of the population in terms of geographical spread, maternal education, and environmental context was obtained through stratified sampling. METHOD: The Arabic CDI Toddler, containing a 100-word list with dialect …

Assessing Physicians' Agreement And The Completeness Of The Decision Aid ‘Arriba Diabetes’: A Cross-Sectional Study, Nicole Lindner, Marie-Christine Hoffmann, Jörg Haasenritter, Jan K. Woike, Norbert Donner-Banzhoff

School of Psychology

No abstract provided.

Remote Sensing-Based Assessment Of Evapotranspiration Patterns In A Unesco World Heritage Site Under Increasing Water Competition, Maria C. Moyano, Monica Garcia, Luis Juana, Laura Recuero, Lucia Tornos, Joshua B. Fisher, Néstor Fernández, Alicia Palacias-Orueta

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

In water-scarce regions, natural ecosystems and agriculture increasingly compete for limited water resources, intensifying stress during periods of drought. To assess these competing demands, we applied a modified PT-JPL model that incorporates the thermal inertial approach as a substitute for relative humidity (RH) in estimating soil evaporation—a method that significantly outperforms the original PT-JPL formulation in Mediterranean semi-arid irrigated areas. This remote sensing framework enabled us to quantify spatial and temporal variations in water use across both natural and agricultural systems within the UNESCO World Heritage site of Doñana. Our analysis revealed an increasing evapotranspiration (ET) trend in intensified agricultural …

Comparison Of Shear Bond Strength Of New And Rebonded Symetri™ Clear Ceramic Brackets, Ciara Schwarz

Master's Theses (2009 -)

Objective: The purpose of this study was to compare the shear bond strength of the Symetri™ Clear brackets bonded initially to enamel versus after rebonding. An additional aim was to see how a generic debond pliers compares to the Symetri™ Debonding pliers in terms of shear bond strength and bracket morphology after debond. Methods: Sixty extracted premolars and nine extracted canines were collected and stored in 1% Chloramine T solution. The canines were used for a pilot study to test methodology. The premolars were randomly assigned to one of three Groups: Group 1 (single bond), Group 2A (debond with Symetri™ …

Systemic Carbonic Anhydrase Inhibitors In Common Ophthalmic Diseases: A Scoping Review From A Clinical Standpoint, Shahin Hallaj, Wesam S. Shalaby, Sapna Sinha, Jonathan S. Myers, Reza Razeghinejad

Wills Eye Hospital Papers

PURPOSE OF REVIEW: This paper provides a detailed overview of systemic carbonic anhydrase inhibitors (CAIs) and their application in managing ophthalmic conditions, including glaucoma, cystoid macular edema, and idiopathic intracranial hypertension. Despite their recognized clinical benefits, the potential for severe systemic adverse effects often discourages clinicians from prescribing these agents. By examining the pharmacology, pharmacokinetics, safety profile, and clinical indications of systemic CAIs, this review highlights strategies to mitigate treatment challenges, particularly in patients with comorbidities and complex medical backgrounds.

RECENT FINDINGS: New insights into the diverse roles and distribution of carbonic anhydrase (CA) isozymes have expanded our understanding of …

Zoo Visitors Learn By Observing Olive Baboons (Papio Anubis) Participate In Cognitive Research Or Engage In Natural Behaviors, Anna Sofia Hege

Theses

I conducted two experiments at the baboon exhibit at the Seneca Park Zoo in Rochester, New York to measure attitudes and actual knowledge in children and adults, as well as perceived learning in adults. I also recorded caregiver-child conversations in the presence and absence of live research. Experiment 1 included 150 adult participants, and Experiment 2 included 18 caregiver-child dyads. In each experiment, the research on-scientist present and research on-scientist absent group watched the baboons engage with live cognitive research while the research off-scientist present and research off-scientist absent group watched the baboons carry out their natural behaviors. A scientist …

Ensuring Data Quality In Large International Development Projects: Tools, Strategies, And Lessons Learned, Jennifer Sdunzik, Ann M. Bessenbacher, Wilella D. Burgess, Asia M. Mohamud, Abdirisak Dalmar

Somalia Education Evaluation Publications

The success of development projects and evaluations hinges on having access to research protocols and methodologies that consider the needs and characteristics of stakeholders, subjects, and context while remaining rigorous and culturally sound. These efforts are often complicated by a dearth of tools that have been tested for validity and reliability in communities of interest and data collection environments that necessitate reliance on international and domestic partners with varying backgrounds to collect, process, and share data. Overcoming these challenges requires flexibility, intentionality, and continuous improvement across all partners. This article describes lessons learned from a mixed-methods longitudinal evaluation of an …