Digital Commons Network^™

The State Of School-Based Ot Practice Regarding Concussion-Related Vision Disorders, Kimberly Meany, Emily Behnke, Ariks Lanctot, Audrey Maynard, Samuel Szarowicz

Masters Projects

Purpose: More than 830,000 pediatric patients yearly are affected by a concussion (Rosenbaum, 2020). Occupational therapists can support a child's performance in the classroom. Yet, there is a lack of knowledge regarding the current practice of occupational therapists treating those with a concussion in the school setting. Therefore, the purpose of this study is to understand school-based occupational therapy practice regarding concussion-related vision disorders.

Design: Cross-sectional survey. Participants were licensed OTs practicing in the US, working in a school-based or related pediatric setting, with more than two years of pediatric experience, holding at least a bachelor’s degree from an accredited …

Blunted Cd40-Responsive Enhancer Activation In Crebbp-Mutant Lymphomas Can Be Restored By Enforced Cd4 T-Cell Engagement, Haopeng Yang, Wenchao Zhang, Vida Ravanmehr, Guiling Cui, Kevin Bowman, Ruidong Chen, Jared M Henderson, Shyanne Lockman, Estela Rojas, Ashley Wilson, Sydney Parsons, Ariel Mechaly, Leslie Regad, Ahmed Haouz, Christopher R Flowers, Sattva Neelapu, Loretta Nastoupil, R Eric Davis, Qing Deng, Fernando Rodrigues-Lima, Michael R Green

Faculty, Staff and Student Publications

The CREBBP lysine acetyltransferase (KAT) is frequently mutated in follicular lymphoma and diffuse large B-cell lymphoma and has been studied using gene knockout in murine and human cells. However, most CREBBP mutations encode amino acid substitutions within the catalytic KAT domain (CREBBP KAT-PM) that retain an inactive protein and have not been extensively characterized. Using CRISPR gene editing and extensive epigenomic characterization of lymphoma cell lines, we found that CREBBP KAT-PM lead to unloading of CREBBP from chromatin, loss of enhancer acetylation, and prevention of EP300 compensation. These enhancers were enriched for those that are dynamically loaded by CREBBP in …

Prognostic Value Of Lipoprotein(A) For Cardiovascular Events After Lower Limb Revascularization In Diabetic Patients With Chronic Limb-Threatening Ischemia, Federico Biscetti, Maria Margherita Rando, Maria Anna Nicolazzi, Flavia Angelini, Roberto Iezzi, Luis H. Eraso, Paul J. Dimuzio, Dario Pitocco, Massimo Massetti, Antonio Gasbarrini, Andrea Flex

Department of Surgery Faculty Papers

BACKGROUND: Chronic limb-threatening ischemia (CLTI) presents a major clinical challenge in patients with Type 2 Diabetes Mellitus (T2DM), requiring lower extremity revascularization (LER) to mitigate adverse cardiovascular and limb outcomes. Lipoprotein(a) (Lp(a)) has been implicated in cardiovascular risk, but its role in patients with T2DM and CLTI undergoing revascularization remains unclear. Thus, this study aimed to investigate the prognostic value of Lp(a) levels in diabetic CLTI patients for major adverse cardiovascular events (MACE), major adverse limb events (MALE), or both after LER.

METHODS: In this prospective cohort study of 158 individuals with T2DM and CLTI undergoing LER, baseline clinical data …

Hybrid Reference Genome Assemblies For Leishmania (Viannia) Braziliensis, A Primary Agent Of Mucocutaneous Leishmaniasis, James A Cotton, Frederik Van Den Broeck, Peter J Myler, Natalia S Akopyants, Matthew Berriman, Stephen M Beverley

2020-Current year OA Pubs

We report high-quality long-read genome assemblies and annotations for two widely studied reference strains of

Comparative Transcriptomic Analysis Of Mouse Macrophages Infected With Live Attenuated Vaccine Strains Of Mycobacterium Tuberculosis, Raja Veerapandian, Barbara Yang, Areanna Carmona, Melina J. Sedano, Victoria Reid, Rodrigo Jimenez, Jessica Chacon, Chinnaswamy Jagannath, Enrique I. Ramos, Shrikanth Gadad, Subramanian Dhandayuthapani

School of Medicine Publications

The BCG vaccine has been used against tuberculosis (TB) for over a hundred years; however, it does not protect adults from pulmonary TB. To develop alternative vaccines against TB, we generated Mycobacterium tuberculosis H37Rv (Mtb)-derived vaccine strains by rationally deleting key virulent genes, resulting in single (SKO; ΔfbpA), double (DKO; ΔfbpA-ΔsapM), triple (TKO-D; ΔfbpA-ΔsapM-ΔdosR and TKO-Z; ΔfbpA-ΔsapM-Δzmp1), and quadruple (QKO; ΔfbpA-ΔsapM-Δzmp1-dosR) strains. To understand how macrophages, the host cells that defend against infection and process antigens for presentation to immune cells, respond to these vaccine strains, we performed transcriptomic analyses of mouse bone marrow-derived macrophages …

Lysosomal Storage Disorders In Nonimmune Hydrops Fetalis Diagnosed By Exome Sequencing, Mona M Makhamreh, Kavya Shivashankar, Stephanie M. Rice, Sascha Wodoslawsky, Christina Grant, Rodney Mclaren, Seth I. Berger, Huda B. Al-Kouatly

Department of Obstetrics and Gynecology Faculty Papers

Lysosomal storage disorders (LSD) are a group of inherited metabolic diseases that contribute to nonimmune hydrops fetalis (NIHF). Our objective was to review the pooled exome sequencing (ES) diagnostic yield of LSD in NIHF cases. We expanded our previous meta-analysis and updated our search strategy of prenatal ES studies from 1/1/2000 to 8/1/2024. Cases with LSD gene variants were reviewed. Variants were curated based on the current American College of Medical Genetics and Genomics and ClinGen guidelines. Forty-one ES studies met our inclusion criteria. A total of 207/558 NIHF cases yielded a positive diagnosis by ES. LSD cases represented 27/558 …

Integrase-Deficient Lentiviral Vector As A Platform For Efficient Crispr/Cas9-Mediated Gene Editing For Mucopolysaccharidosis Iva, Fnu Nidhi, Shunji Tomatsu

Department of Pediatrics Faculty Papers

Mucopolysaccharidosis IVA (MPS IVA) is a lysosomal storage disorder causing systemic skeletal dysplasia due to a deficiency of N-acetyl-galactosamine-6-sulfate sulfatase (GALNS) enzyme activity, leading to the impaired degradation and accumulation of glycosaminoglycans (GAGs), keratan sulfate (KS) and chondroitin-6-sulfate. While treatments such as enzyme replacement therapy (ERT) and hematopoietic stem cell transplantation (HSCT) are available, they have significant limitations regarding efficacy in skeletal tissues and long-term safety, highlighting the need for more effective therapies. We evaluated a novel gene therapy approach using a dual Integrase-deficient lentiviral vector (IDLV) to deliver an expression cassette that includes human GALNS cDNA and Cas9 sgRNA, …

Ruptured Atlas: A Trauma-Informed Approach To Spatial Storytelling For Survivors Of Genocide (The Case For Yazidis In Iraq), Sana Murrani, Kimbal Bumstead, Zoe Paris, Ghazi Murad Ismael, Jameela Rasho, Omeed Khider Joqey

School of Art, Design and Architecture

The Ruptured Atlas project (December 2023 – December 2024) employs innovative, participatory mapping techniques to document the complex spatial and lived experiences of the Yazidi community in the aftermath of the genocide perpetrated by ISIS, which commenced in August 2014. This collaborative effort involves 15 Yazidi researchers and key partners, culminating in an online atlas and a trauma-informed policy toolkit. Designed to influence housing and migration policies in both Iraq and the UK, the project prioritises trauma-informed practices and community empowerment. The online atlas was not only a conceptual device, but a vital visual tool, enabling participants to represent trauma …

The Impact Of Genetic Ancestry On Survival Outcomes In Pediatric Rhabdomyosarcoma: A Report From The Children’S Oncology Group, Ekene A Onwuka, Christina L Magyar, Bailey A Martin-Giacalone, Michael E Scheurer, Deborah A Marquez-Do, Mark Zobeck, Elizabeth G Atkinson, Erin R Rudzinski, Michael A Arnold, Donald A Barkauskas, David Hall, Javed Khan, Jack F Shern, Paul Scheet, Brian Crompton, Corinne M Linardic, Douglas S Hawkins, Rajkumar Venkatramani, Lisa Mirabello, Chad D Huff, Melissa A Richard, Philip J Lupo

Faculty, Staff and Student Publications

Emerging evidence suggests genetic ancestry may influence childhood cancer outcomes, but its impact on pediatric rhabdomyosarcoma (RMS) is unknown. We explored genetic ancestry's impact on survival among children with RMS. This multi-center observational cohort study is a secondary analysis of previously collected biobanking, genomic, and clinical data. The study included 920 individuals with newly diagnosed RMS under 40 years of age enrolled from 2005 to 2017 under the COG soft tissue sarcoma biobanking protocol D9902. The primary endpoints were (1) event-free survival (EFS), defined as the time from study enrollment to tumor recurrence/progression, secondary malignancy, or death from any cause; …

Global Diversity Of Soil-Transmitted Helminths Reveals Population-Biased Genetic Variation That Impacts Diagnostic Targets, Marina Papaiakovou, Andrea Waeschenbach, Olumide Ajibola, Sitara Sr Ajjampur, Roy M Anderson, Robin Bailey, Jade Benjamin-Chung, Maria Cambra-Pellejà, Nicolas R Caro, David Chaima, Rubén O Cimino, Piet Cools, Anélsio Cossa, Julia Dunn, Sean Galagan, Javier Gandasegui, Berta Grau-Pujol, Emma L Houlder, Moudachirou Ibikounlé, Timothy P Jenkins, Khumbo Kalua, Eyrun F Kjetland, Alejandro J Krolewiecki, Bruno Levecke, Adrian Jf Luty, Andrew S Macdonald, Inácio Mandomando, Malathi Manuel, Maria Martínez-Valladares, Rojelio Mejia, Zeleke Mekonnen, Augusto Messa, Harriet Mpairwe, Osvaldo Muchisse, Jose Muñoz, Pauline Mwinzi, Valdemiro Novela, Maurice R Odiere, Charfudin Sacoor, Judd L Walson, Steven A Williams, Stefan Witek-Mcmanus, D Timothy J Littlewood, Cinzia Cantacessi, Stephen R Doyle

Faculty, Staff and Students Publications

Soil-transmitted helminths (STHs) are intestinal parasites that affect over a billion people worldwide. STH control relies on microscopy-based diagnostics to monitor parasite prevalence and enable post-treatment surveillance; however, molecular diagnostics are rapidly being developed due to increased sensitivity, particularly in low-STH-prevalence settings. The genetic diversity of helminths and its potential impact on molecular diagnostics remain unclear. Using low-coverage genome sequencing, we assess the genetics of STHs within worm, faecal, and purified egg samples from 27 countries, identifying differences in the genetic connectivity and diversity of STH-positive samples across regions and cryptic diversity between closely related human- and pig-infective species. We …

Innovations In Tavr: The Latest In Device Technology, Omar Sheikh, Errol Moras, Lorraine Mascarenhas, Sahar Samimi, Waleed T Kayani, Syed Zaid

Faculty, Staff and Students Publications

Aortic stenosis is the most prevalent valvular disease globally. Transcatheter aortic valve replacement (TAVR) has become a well-established treatment for aortic stenosis, offering outcomes comparable to surgical aortic valve replacement (SAVR). Its use has expanded to include younger, lower-risk patients and those with more complex anatomies. Recent advancements in TAVR include the increased adoption of transfemoral access, prosthesis designs optimized for challenging anatomies, enhanced delivery systems with repositioning capabilities, and outer skirts to minimize paravalvular leaks. Despite these innovations, several challenges remain. This review highlights recent updates in transcatheter heart valve (THV) systems, leaflet modification devices, and the current limitations …

Weaning Beef Calves, David Secrist

All Current Publications

Weaning a beef calf is likely the most stressful event in the animal’s life. Future growth and reproductive performance can be compromised by health challenges encountered through the weaning process. Consequently, proper management aimed at reducing stress and preparing the beef animal for the next stage of production is critical to reach its genetic potential. Proper management involves applying good animal husbandry techniques, using sound science in developing health and feeding protocols, and implementing low-stress animal handling practices.

Braf V600e-Positive Mononuclear Cells In Blood At Diagnosis Portend Treatment Failure And Neurodegeneration In Pediatric Lch, Howard Lin, Akanksha Batajoo, Erin Peckham-Gregory, Daniel Zinn, Olive S Eckstein, Nader Kim El-Mallawany, Nitya Gulati, Zachary D Prudowsky, Brooks Scull, Jessica Velazquez, Harshal Abhyankar, Stephen J Simko, Daria Vakula, Ryan Fleischmann, Vivekanudeep Karri, M John Hicks, Kevin E Fisher, Choladda V Curry, Angshumoy Roy, Deborah Schiff, Kenneth M Heym, Michael E Scheurer, D Williams Parsons, Miriam Merad, Tsz-Kwong Man, Kenneth L Mcclain, Jennifer Picarsic, Carl E Allen

Faculty, Staff and Students Publications

Langerhans cell histiocytosis (LCH) is a myeloid neoplastic disorder driven by mitogen-activated protein kinase (MAPK) activation in hematopoietic cells. Historically, LCH has been staged according to involvement of "risk organs" (bone marrow, liver, and spleen), based on risk of death. With improvements in supportive care and efficacy of MAPK pathway inhibitors, patients with LCH now rarely die. However, most patients with LCH with multisystem disease are not cured with current front-line chemotherapy, and treatment failure is associated with long-term morbidity, including LCH-associated neurodegeneration (LCH-ND). In this study, we evaluated the impact of extent of LCH at presentation, tumor genotype, and …

Osteogenesis Imperfecta And The Family: A Qualitative Analysis Of The Experiences Of Family And Caregivers, Gianna M Colombo, Andrew D Wiese, Amelia E Mercado, Whitney S Shepherd, Michelle Fynan, Kara Ayers, W Conor Rork, Kristin M Kostick-Quenet, Dianne Nguyen, Sophie C Schneider, Julia M Morales, Saniah I Kazimi, Hannah E Cho, Members Of The Bbdc, Chaya N Murali, Marie-Eve Robinson, Brendan Lee, V Reid Sutton, Eric A Storch

Center for Medical Ethics and Health Policy Staff Publications

Introduction: Osteogenesis imperfecta (OI) describes a group of rare, heritable bone disorders causing bone fragility, tendency to fracture with minimal trauma, and chronic pain due to abnormal collagen synthesis. Limited research exists on the psychosocial impact of OI during childhood on caregivers and families.

Purpose: This study aimed to understand caregiver experiences, existing social support provided for families affected by OI, and the impact of OI on family life.

Method: Thirteen caregivers of individuals with OI participated in semistructured interviews. Researchers coded, abstracted, and analyzed qualitative data to develop themes on the psychosocial impact of OI on the family unit. …

The Need For Targeted Prevention And Screening In Gastrointestinal Cancer Disparities, Jason C. Lin, John C. Lin, Joy Zhao

Division of Gastroenterology and Hepatology Faculty Papers

No abstract provided.

Conversational Systems For Social Care In Older Adults: Protocol For A Scoping Review, Rosiered Brownson-Smith, Ananya Ananthakrishnan, Oksana Hagen, Cen Cong, Amir Aly, Ray B. Jones, Edward Meinert

School of Engineering, Computing and Mathematics

Background: Social care systems worldwide face increasing demographic and financial pressures. This necessitates exploring innovative technological solutions to enhance service delivery without substantially increasing costs. Conversational interfaces, including interactive voice response, chatbots, and voice assistants, have gained traction as a means to improve accessibility and efficiency in social care. The rapid development of large language models such as ChatGPT has further accelerated interest in conversational artificial intelligence (AI). These technologies can offer intuitive interactions, particularly for individuals with limited digital literacy. However, their real-world impact, usability, and ethical considerations in social care remain underexplored. Objective: This scoping review aims to …

مُستوى مَعرِفة معلِّمي الدراساتِ الاجتماعيّة للتعليم ما بعد الأساسي في سَلطنة عُمان بالأوبئة. The Level Of Knowledge Of Social Studies Teachers In Post-Basic Education Schools In The Sultanate Of Oman About Epidemics, رحمة علي البدوي, سيف ناصر المعمري

Association of Arab Universities Journal for Education and Psychology

هدفتِ الدراسةُ الحالية تعرف مستوى معرفة معلمي الدراسات الاجتماعية للتعليم ما بعد الأساسي في سلطنة عُمان بالأوبئة، علاوة على كشفِ أثرِ مُتغيِّر النوعِ، والتخصص، وسنوات الخبرة، والمحافظة، ومعدل متابعة أخبار كوفيد19، ومصادر الحصول على المعلومات الصحية خلال الجائحة، ومدى الالتزام بالإجراءات الوقائية، وظَّفت الدراسة المَنهجَ الوصفي من خلال إعدادِ اختبار معارف تكوَّن من ستة محاور، هي: مفهوم الأوبئة، تاريخ الأوبئة، أسباب انتشار الأوبئة، الآثار المترتبة عن انتشار الأوبئة، طرق علاج الأوبئة، دور سلطنة عُمان في مكافحة الأوبئة. طُبقت على عينة مكونة من (200) من مُعلِّمي الدراسات الاجتماعيَّة في سلطنة عُمان. وكشفت النتائج أن مستوى معرفة المُعلِّمين بالأوبئة منخفضًا، كما بيّنت …

القيادة الاستباقية وعلاقتها بإدارة مخاطر البيئة المدرسية لدى مديري مدارس الرمثا. Proactive Leadership And Its Relationship To School Environment Risk Management Among Ramtha School Principals, لانا عبد المولى العنزي, محمد عبود الحراحشة

Association of Arab Universities Journal for Education and Psychology

هدفت هذه الدراسة التعرف إلى درجة ممارسة القيادة الاستباقية وعلاقتها بإدارة مخاطر البيئة المدرسية لدى مديري مدارس الرمثا. ولتحقيق هدف الدراسة تم استخدام المنهج الوصفي المسحي الارتباطي، واختيار عينة عشوائية بسيطة تكونت من (340) معلما ومعلمة. تم تطوير استبانة تكونت من محورين الأول لقياس درجة القيادة الاستباقية تضمنت (32) فقرة، أما المحور الثاني فكان لقياس درجة ممارسة إدارة مخاطر البيئة المدرسية وتضمنت (29) فقرة، وذلك بعد أن تم التحقق من صدقها وثباتها. وتوصلت الدراسة إلى أن درجة ممارسة القيادة الاستباقية من وجهة نظر المعلمين مرتفعة، وبينت نتائج الدراسة إلى أن درجة ممارسة إدارة مخاطر البيئة المدرسية من وجهة نظر المعلمين …

The Tax Adviser, Volume 11, Number 7, July 1980, American Institute Of Certified Public Accountants

Tax Adviser

No abstract provided.

Life Insurance Companies And The Income Tax: Recent Judicial Developments, Gordon O. Pehrson Jr., Carolyn P. Chiechi, John T. Adney

Tax Adviser

No abstract provided.

Tax Trends, E. S. Linett

Tax Adviser

No abstract provided.

Predicting The Impact Of Climate Change On The Distribution Of Monodelphis Domestica (Wagner, 1842), Salise Sepulveda, Noé U. De La Sancha

DePaul Discoveries

Understanding the impact of climate change on species distribution is necessary to properly develop plans that conserve or prepare for maintenance of crucial ecosystems. Monodelphis domestica is a small mammal species native to Argentia, Bolivia, Brazil, and Paraguay. This species is known for its high adaptability and preference for living in wet conditions. Using bioclimatic variables, generalized linear models (GLM), and Coupled Model Intercomparison Project Phase 6 (CMIP6) we predicted how this species distribution will change within the next 75 years under different climate and anthropogenic changes. The results have shown that the distribution of M. domestica will remain relatively …

Measuring And Mapping Spatial Distributions Of Soil Lead Concentrations Across An Urban-To-Rural Gradient In Chicagoland, Lulia Woldemicael, Andrea Stoeva

DePaul Discoveries

Lead (Pb), a highly toxic chemical has found its way into many aspects of our communities through a plethora of different pathways such as paint, gasoline, and industrial activity. Exposure to lead poses harmful risks to all age groups as a higher blood lead level is associated with higher mortality. Although actions have been taken to eliminate lead from the atmosphere, it remains in the environment, especially accumulating in urban areas where the use of automobiles and highly industrialized landscapes are prevalent. This study examines the soil lead concentrations along an urban-to-rural gradient connecting Humboldt Park, Skokie, and Buffalo Grove, …

Fireworks And Wood Combustion Impacts On Air Quality, Iris Keller

DePaul Discoveries

Fire is used as a land management tool to improve ecosystem health and to reduce wildfire risk by lowering tree and litter density. However, prescribed fire as a management practice has faced difficulties with public perception, because of increased awareness of air pollution. Understanding the way that prescribed burns impact air quality and how beneficial they are for ecosystems can help the public to recognize their necessity. This study measured particulate matter (PM) emissions from prescribed burns but also considered other PM sources: fireworks and bonfires. The measurements were conducted in Minnesota, Wisconsin, and the Chicagoland area in the summer …

Factors Motivating Clothing Choice: Environmental Impact Of T-Shirts, Lauren Hunt

DePaul Discoveries

Second only to oil, the fashion industry is one of the most pollutive industries globally. Due to the rise of fast fashion, this environmental issue is continually growing. The level of production has dramatically increased while quality of apparel has decreased, causing shorter garment lifespans. This research utilizes life cycle assessment to identify the environmental impacts of various textiles used in the production of t-shirts, including cotton, polyester, viscose, and elastane. The research scope focuses from material extraction through garment disposal. The life cycle assessment research is paired with a community survey to determine consumer behavioral patterns surrounding clothing consumption …

Environmental Justice And Soil Lead Contamination: Spatial Analysis Across Seven Community Areas, Arsene Lionel Apabaga

DePaul Discoveries

Pb is a pervasive metal with toxicity linked to numerous human health issues. Urban soil is a well-documented environmental sink for Pb, persisting as a legacy pollutant decades after the phaseout of leaded gasoline. This study measured, mapped, and analyzed the spatial distribution of total soil Pb concentrations across seven Chicago Community Areas (CCAs). The objectives were to: (1) assess the relationship between mean soil Pb concentration and mean Community Environmental Justice Index (CEJI) score per CCA, (2) determine the relationship between soil Pb levels and the percentage of industrial land use, and (3) quantify and compare the percentage of …

Values And Barriers: A Multidimensional View Of College Students’ Motivations To Volunteer, Gavin Warner, Quang Anh Nguyen, Ansuk Jeong

DePaul Discoveries

University students tend to have ample access to many resources for volunteering and so are in a unique position among Americans. With all the benefits of volunteering outlined in past research, the students training to become leaders in their fields may have the most to gain from volunteerism. It is surprising, then, to note that young people are less likely to volunteer than other age groups. Why is it that college students tend to volunteer at such low rates? The current study seeks to answer this question through a mixed-methods survey. A qualitative section clarified which specific barriers students felt …

The Role Of Maternal Attachment In The Relation Between Acculturative Stress And Mental Health Among Latinx Youth, Melisa Dangles, Evelin Regalado, Antonio Polo

DePaul Discoveries

Acculturative stress is a significant psychological challenge faced by Latinx youth as they navigate cultural adaptation, often leading to negative mental health outcomes. Research has shown that acculturative stress is positively associated with major depression, anxiety, and high-risk behaviors, including delinquency and impulse control problems (Lerias et al., 2024). This study examines the role of maternal attachment as a mediator in the relation between acculturative stress and both depressive symptoms and externalizing problems among Latinx youth. The sample consisted of 281 Latinx students (ages 10-14, M = 11.4, SD = 0.95) from several Chicago Public Schools. Results indicate that acculturative …

“Put Me In Coach!”: The Impact Of College Sport Team’S Mentorship In Chronically Ill And Disabled Children And Adolescents Adherence To Medical Regimen, Jameela Askira

DePaul Discoveries

The purpose of this study was to see if participation in TeamIMPACT, a program which matches ill children with college sports teams, aided chronically ill children and adolescents in adhering to their treatment regimen. This research is a part of a larger study where 25 child participants were interviewed via Zoom to answer questions regarding their time in the program, peer and family relationships, coping and resilience and other factors. The current study solely analyzed answers to questions regarding adherence to medical treatments. There were three measures: Child vs Parent Response, Treatment Regimen Components and Care Responsibility. Through a descriptive …

Frustrated, But Motivated: Insights From People With Me/Cfs, Aiden Rathmann, Suvetha Ravichandran, Leonard A. Jason

DePaul Discoveries

Qualitative research can amplify and clarify the perspectives of people with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). The current study analyzed responses to an open-ended survey question regarding the experiences of people with ME/CFS, especially in relation to ME/CFS case definitions. Although many people with ME/CFS are frustrated with their interactions with healthcare workers and researchers, people with this illness want these individuals to listen to them about their experiences with health care and research.