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The Construction Of Ph- And Temperature-Responsive Drug Delivery Systems Based On Metal Organic Frameworks And Phase Change Materials, Wanying Wei

Theses and Dissertations

In this study, core-shell microparticles were synthesized using coaxial electrospray techniques, with Zeolitic Imidazolate Framework-8 encapsulating either Rhodamine B or Doxorubicin in the core. ZIF-8 is a material well regarded for its effectiveness in drug delivery systems. Phase change materials are composed of a 4:1 mixture of lauric acid and stearic acid in the shell. The PCM chosen has a melting point close to physiological body temperature. The structural morphology and thermal stability of the microparticles were confirmed using Scanning Electron Microscopy, X-ray Diffraction, Differential Scanning Calorimetry, Thermogravimetric Analysis, and Infrared Spectroscopy. The release of the drug was influenced by …

High- Speed Wireless Interference Separation Based On Photonic Deep Learning Accelerators And Three-Dimensional Image Reconstruction For Medical Applications, Taichu Shi

Theses and Dissertations

This dissertation is centered on fast wideband interference management through advanced photonic signal processing and hybrid communication architectures. The core of this work is based on an optical pulse sampling technique proposed for photonic blind source separation (BSS) to recover wideband signals from their sub-Nyquist samples. With the use of ultra-short optical pulses to obtain statistically representative samples, this method retains important statistical properties of the signals while significantly reducing constraints imposed by analog to digital conversion and digital signal processing. Building on this foundation, we further apply the photonic BSS system within a hybrid free space optical (FSO) and …

Exploring The Effect Of Led-To-Photodetector Spacing On Subcutaneous Photoplethysmography For Continuous Blood Pressure Measurement, Dario Cabal, Brian Nguyen, David B. Green, Kevin Kilgore, Varun Thakkar, Michael J. Fu, Steve J. Majerus

Student Scholarship

Photoplethysmography (PPG) is widely used to measure heart rate, blood oxygenation, and more recently, blood pressure. Implanted PPG systems offer the possibility to measure similar real-time measures of cardiovascular health, however, the detection method may vary due to a lack of capillary vessels for PPG sensors to observe in muscle tissue. To improve volumetric blood detection in large muscles, without relying on the capillary density of skin, a flexible PPG sensor was developed. The sensor included multiple spacing of illuminating infrared (IR) light emitting diodes (LEDs) and a single IR photodetector. This arrangement was expected to enable detection of blood …

Distinguishing Primary And Secondary Anomalous Self-Experience Using Momentary Variability, Michael D. Masucci

LSU Doctoral Dissertations

Schizophrenia is associated with significant decreases in functioning and costly psychiatric hospitalization. However, it is frequently misdiagnosed due to phenotypic overlap with other disorders, and misdiagnosis can contribute to its functional and economic cost. Schizotypy and psychosis risk syndrome frameworks have been used to predict who will eventually develop schizophrenic psychosis, but accurate prediction caps at about 30% for individuals who are identified as “at risk” by these frameworks. Anomalous Self Experience (ASE), an alternative framework for understanding psychosis risk developed by phenomenological psychiatry, proposes that identifying fundamental alterations to sense of self are specific to schizophrenia and distinguish those …

Revalidation Of The Child Routines Questionnaire: Preschool, Christian Olivia Ledet

LSU Doctoral Dissertations

The implementation of consistent, structured routines is considered a positive parenting practice that enhances child development and is a protective factor for developing externalizing behavior problems, particularly for preschool-age children as they learn to regulate their behavior. In recent years, electronic media consumption has increased among children of all ages, and excessive use is related to negative outcomes for children. Thus, a measure assessing routines of preschool children with items related to electronic media routines is important to further understand how routines affect children’s emotional and behavioral regulation and their interactions with their parents. The purpose of the current study …

The Virtual Kitchen Challenge: Psychometric Validation In Cognitively Healthy And Impaired Older Adults, Ross M. Divers

LSU Doctoral Dissertations

Decline in everyday functioning is core diagnostic criteria for mild cognitive impairment (MCI) and dementia. While historically, MCI was considered a stage of generally persevered everyday functioning, it is now widely accepted that subtle though clinically meaningful changes in everyday function can be observed and are predictive of increased risk of future decline and conversion to dementia. Despite this, self and informant report questionnaires of everyday function largely fail to capture this subtle decline in those with MCI, while performance-based measures that may be able to capture this decline are rarely administered clinically due to their laborious administration. Performance-based measures …

Self-Other Generalisation Shapes Social Interaction And Is Disrupted In Borderline Personality Disorder, Joseph M Barnby, Jen Nguyen, Julia Griem, Magdalena Wloszek, Henry Burgess, Linda J Richards, Jessica Kingston, Gavin Cooper, P Read Montague, Peter Dayan, Tobias Nolte, Peter Fonagy, London Personality And Mood Disorders Consortium

2020-Current year OA Pubs

Generalising information from ourselves to others, and others to ourselves allows for both a dependable source of navigation and adaptability in interpersonal exchange. Disturbances to social development in sensitive periods can cause enduring and distressing damage to lasting healthy relationships. However, identifying the mechanisms of healthy exchange has been difficult. We introduce a theory of self-other generalisation tested with data from a three-phase social value orientation task - the Intentions Game. We involved humans with (

Parental Attitudes To Risky Play And Children’S Independent Mobility: Public Health Implications For Children In Ireland, Fiona Armstrong, Michael Joseph Barrett, David Gaul, Lorraine D’Arcy

Research Outputs: 2025-Present

Background: Understanding the determinants of children’s outdoor play is an important element for child development and broader public health outcomes. There is growing evidence that children’s opportunities for play, particularly outdoor risky play, are diminishing. Parents are concerned with keeping their child safe while affording them independence to play. This study explored parents’ attitudes to risky play and practices around children’s independent mobility in Ireland with the aim of informing public health strategies promoting healthy childhood environments. Methods: An online survey comprising validated scales and standardised questions was completed by a nationally represented sample of 376 parents of children up …

Board Of Directors Meeting Minutes (July 14, 2025), Dmacc

Board of Directors Meeting Minutes

This file contains the minutes from the Des Moines Area Community College Board meeting held on July 14, 2025.

The Role Of The Cytosolic Chaperonin Cct In The Folding And Assembly Of G Protein Complexes, Mikaila I. Sass

Theses and Dissertations

All organisms depend on cellular signaling pathways to dictate cell growth, responses to stimuli, and all other cellular functions necessary to maintain health and survival. Many of these signals rely on G protein coupled receptors (GPCRs) and their associated heterotrimeric G proteins for signal detection and transduction. To perform this function, the three subunits of the G protein must be assembled after synthesis on the ribosome. This process requires additional proteins called molecular chaperones to assist in folding of the subunits and assembly into the G protein heterotrimer. Among these chaperones, the cytosolic chaperonin CCT plays an essential role in …

"Chatgpt Told Me To Say It": Ai Chatbots And Class Participation Apprehension In University Students, Daisuke Akiba

Publications and Research

The growing prevalence of AI chatbots in everyday life has prompted educators to explore their potential applications in promoting student success, including support for classroom engagement and communication. This exploratory study emerged from semester-long observations of class participation apprehensions in an introductory educational psychology course, examining how chatbots might scaffold students toward active and independent classroom contribution. Four students experiencing situational participation anxiety voluntarily participated in a pilot intervention using AI chatbots as virtual peer partners. Following comprehensive training in AI use and prompt design given to the entire class, participants employed systematic consultation frameworks for managing classroom discourse trepidations. …

Mitral Valve Repair During Cabg Surgery: Navigating The Gray Area Of Moderate Ischemic Mitral Regurgitation, Husam Shadid, Ismael A. Salas De Armas, Marwan F. Jumean

Journal of Shock and Hemodynamics

Ischemic mitral regurgitation is a consequence of prior myocardial infarction, resulting in regional wall motion abnormalities, leaflet tethering, papillary muscle displacement, and annular dilatation. In patients with multivessel coronary artery disease, approximately 30-50% develop moderate to severe ischemic mitral regurgitation, associated with a threefold increase in the incidence of congestive heart failure and cardiac death. We present a case involving a 66-year-old male with multivessel coronary artery disease, heart failure with reduced ejection fraction (30-35%), and diabetes who was found to have moderate ischemic mitral regurgitation at the time of coronary artery bypass graft surgery. The decision to pursue mitral …

Selection In Surveys: Using Randomized Incentives To Detect And Account For Nonresponse Bias, Deniz Dutz, Ingrid Huitfeldt, Santiago Lacouture, Magne Mogstad, Alexander Torgovitsky, Winnie Van Dijk

Cowles Foundation Discussion Papers

We show how to use randomized participation incentives to test and account for nonresponse bias in surveys. We first use data from a survey about labor market conditions, linked to full-population administrative data, to provide evidence of large differences in labor market outcomes between survey participants and nonparticipants, differences which would not be observable to an analyst who only has access to the survey data. These differences persist even after correcting for observable characteristics. We then use the randomized incentives in our survey to directly test for nonresponse bias, and find evidence of substantial bias. Next, we apply a range …

The Effects Of A Combined Exercise Intervention On Body Composition, Gdf-15, Apelin-12, And Il-15 Among Older Korean Women According To Obesity Status, Jeongsook Kim, Eadric Bressel, Minkyo Kim, Taekyu Kim, Suhan Koh, Doyeon Kim

Kinesiology and Health Science Faculty Publications

Background: The purpose of this study was to investigate the effects of a 16-week exercise program combining aerobic and resistance training on body composition, growth differentiation factor-15 (GDF-15), apelin-12, and interleukin-15 (IL-15) in older Korean women according to obesity status. Methods: Participants were divided into obesity (n = 15) and normal-weight groups (n = 14). A walking exercise was performed at 60–70% heart rate reserve (RPE 13–15). The bodyweight resistance exercises were progressively intensified over 16 weeks. Analysis methods included two-way repeated measures ANOVA, ANCOVA, and paired and independent t-tests. Results: Significant main effects of time and …

A Review Of Automation In Small Satellite Operations, Joseph Melville, Andrew Narvaez, Lee Jasper

Space Dynamics Laboratory Publications

In the context of congested orbital space, the proliferation of small satellite constellations aims to enhance resilience and responsiveness in on-orbit systems. The escalating number and diversity of small satellites and the need for intersatellite coordination pose operational challenges. Chief among these challenges is that the quantity of operators needed to fully utilize these deployed systems is prohibitively large and expensive; further, operators simply may not be responsive enough to events.

Automated systems, both on-board and ground-based, offer a viable solution to streamline various operational tasks. The integration of automation mitigates the operational burden, minimizes errors originating from human intervention, …

The Overlooked Impact Of Background Diet And Adherence In Nutrition Trials, Javier I Ottaviani, Hagen Schroeter, Dennis M Bier, John W Erdman, Howard D Sesso, Joann E Manson, Gunter G C Kuhnle

Children’s Nutrition Research Center Staff Publications

Randomised controlled trials in nutrition (RCTN) face unique challenges, including the considerable influence of the background diet and the challenge of assuring intervention adherence by participants. The impact of these factors on the outcome of RCTNs has been difficult to quantify, but nutritional biomarkers represent a valuable tool to address these challenges. Using flavanols as a model dietary intervention and a set of recently validated flavanol biomarkers, we here investigated the impact of background diet and adherence on the outcomes of a subcohort of the COcoa Supplement and Multivitamin Outcomes Study (COSMOS, NCT 02422745). We found that 20% of participants …

Nyls Appoints Britney Wilson As Professor Of Law, Anthony W. Crowell

NYLS Community News

No abstract provided.

Spike Timing-Dependent Plasticity And Random Inputs Shape Interspike Interval Regularity Of Model Stn Neurons, Thoa Thieu, Roderick Melnik

School of Mathematical & Statistical Sciences Faculty Publications

Background/Objectives: Neuronal oscillations play a key role in the symptoms of Parkinson’s disease (PD). This study investigates the effects of random synaptic inputs, their correlations, and the interaction with synaptic dynamics and spike timing-dependent plasticity (STDP) on the membrane potential and firing patterns of subthalamic nucleus (STN) neurons, both in healthy and PD-affected states. Methods: We used a modified Hodgkin–Huxley model with a Langevin stochastic framework to study how synaptic conductance, random input fluctuations, and STDP affect STN neuron firing and membrane potential, including sensitivity to refractory period and synaptic depression variability. Results: Our results show that random inputs significantly …

Silent Threats: Awareness And Attitudes To Communication Of Sudep Among Neurologists In India: A Cross-Sectional Study, Rohit Shankar

Peninsula Medical School

Background: International guidelines unequivocally endorse the importance and need to discuss Sudden Unexpected Death in Epilepsy (SUDEP) with people with epilepsy (PWE). India is a country accounting for a sixth of all global epilepsy burden. Despite this little is known of Indian neurologists’ knowledge and attitudes to SUDEP. Objective: To explore India Neurologists awareness and attitudes to SUDEP communication to PWE. Methods: A cross-sectional online survey of Likert response questions using validated themes, was circulated among the neurology fraternity, India. Non-discriminatory exponential snowballing technique leading to convenience non-probability sampling was used. The inquiry involved SUDEP-related topics including the awareness, knowledge, …

Differential Roles Of Cyclin–Cdk1 Complexes In Cell Migration And Invasion, Joseph H.R. Hetmanski, Michael J. Jones, Matthew Hartshorn, Patrick T. Caswell, Matthew C. Jones

Peninsula Medical School

We have previously described a central role for CDK1 at the nexus of adhesion signalling and cell cycle progression, demonstrating that CDK1 has a non-canonical role in regulating integrin adhesion complexes and in the migration of cancer cells in 3D interstitial matrix. Here, we show that the CDK1-binding partners cyclinB1 and cyclinA2 also have roles in cell migration and invasion in both cancer and non-transformed cells. CyclinB1 plays a key role in RhoA activation to promote rear retraction in a membrane tension-dependent manner, whereas cyclinA2 has a general role in promoting motility. Knockdown of either cyclin significantly perturbs migration with …

Strategies Leaders In Affordable Housing Can Use To Decrease Property Management Turnover And Increase Professional Tenure, Marisa T. Baldwin-Woodhouse

Walden Dissertations and Doctoral Studies

Executive leaders of rental housing in the affordable housing sector have a high turnover rate of property managers, resulting in wasted time, compliance concerns, loss of institutional knowledge, deterioration of operational costs, and lost revenue, negatively impacting employee commitment. Grounded in the job embeddedness theory, the purpose of this qualitative pragmatic inquiry was to explore effective strategies that some executive leaders in affordable housing can use to decrease property manager turnover and increase professional tenure. The participants comprised eight executive leaders who oversaw property managers in affordable housing in the United States. Data were collected from semistructured interviews, and thematic …

The Potential Of Microbial Fuel Cells As A Dual Solution For Sustainable Wastewater Treatment And Energy Generation: A Case Study, Shajjadur Rahman Shajid, Monjur Mourshed, Md. Golam Kibria, Bahman Shabani

Mechanical and Aerospace Engineering Student Publications and Presentations

Microbial fuel cells (MFCs) are bio-electrochemical systems that harness microorganisms to convert organic pollutants in wastewater directly into electricity, offering a dual solution for sustainable wastewater treatment and renewable energy generation. This paper presents a holistic techno-economic and environmental feasibility assessment of largescale MFC deployment in Dhaka’s industrial zone, Bangladesh, as a relevant case study. Here, treating 100,000 cubic meters of wastewater daily would require a capital investment of approximately USD 500 million, with a total project cost ranging between USD 307.38 million and 1.711 billion, depending on system configurations. This setup has an estimated theoretical energy recovery of 478.4 …

Watching The Grass Grow: Expanding Outreach And Accessibility Of Itex-Aon, Justin Blough

Masters Projects

Science has an accessibility problem. Though results are published and the component data is archived and made publicly available, distrust in and misunderstanding of science by the lay populace remains common. This work focuses on bolstering the outreach component of the International Tundra Experiment (ITEX)—Arctic Observing Network (AON) to increase public awareness, interactivity, and ultimately, the understanding of how the science of ITEX-AON takes place. This project uses several component methods to further outreach goals of ITEX-AON. These include: documentary photography of researchers, study sites, subjects and the surrounding environments, 360-degree imaging and interactive virtual tour building, building interactive data …

Large B Cell Lymphoma Microenvironment Archetype Profiles, Xubin Li, Kartik Singhal, Qing Deng, Dai Chihara, David Russler-Germain, R Andrew Harkins, Jared Henderson, Kotaro Arita, Atish Kizhakeyil, Ryan Sun, Priya Lakra, Usama Hussein, Jennifer A Foltz, Ashley Wilson, Evelyn Schmidt, Imran Nizamuddin, Tommy Dinh, Akhil Kesaraju, Mark P Hamilton, Carl Allen, Maher K Gandhi, Joshua Tobin, Aixiang Jiang, Laura Hilton, David W Scott, Francisco Vega, Christopher R Flowers, Jason R Westin, Obi L Griffith, Todd A Fehniger, Malachi Griffith, Michael R Green

Faculty, Staff and Student Publications

Large B cell lymphomas (LBCL) are clinically and biologically heterogeneous lymphoid malignancies with complex microenvironments that are central to disease etiology. Here we have employed single-nucleus multiome profiling of 232 tumor and control biopsies to characterize diverse cell types and subsets that are present in LBCL tumors, effectively capturing the lymphoid, myeloid, and non-hematopoietic cell compartments. Cell subsets co-occurred in stereotypical Lymphoma Microenvironment Archetype Profiles (LymphoMAPs) defined by; (i) a sparsity of T cells and high frequencies of cancer-associated fibroblasts and tumor-associated macrophages [FMAC]; (ii) lymph node architectural cell types with naïve and memory T cells [LN]; or (iii) activated …

Selective Alanine Transporter Utilization Is A Therapeutic Vulnerability In Arid1a-Mutant Ovarian Cancer, Hao Nie, Liping Liao, Rafal J Zielinski, Javier A Gomez, Akshay V Basi, Erin H Seeley, Lin Tan, Agnes Julia Bilecz, Wei Zhou, Heng Liu, Chen Wang, Shuai Wu, Yuan Qi, Taito Miyamoto, Federica Severi, Aaron R Goldman, Shengqing Gu, Anil K Sood, Amir A Jazaeri, Ronny Drapkin, Daniel T Claiborne, Nan Zhang, Philip L Lorenzi, Jared K Burks, Ernst Lengyel, Eyal Gottlieb, Rugang Zhang

Faculty, Staff and Student Publications

Subunits of the SWI/SNF chromatin remodeling complex are altered in ~20% of human cancers. Exemplifying the alterations is the ARID1A mutation that occurs in ~50% ovarian clear cell carcinoma (OCCC), a disease with limited therapeutic options. Here, we showed that ARID1A mutations create a dependence on alanine by regulating alanine transporters to increase intracellular alanine levels. ARID1A directly repressed alanine importer SLC38A2 and simultaneously promoted alanine exporter SLC7A8. ARID1A inactivation increased alanine utilization predominantly in protein synthesis and passively through the tricarboxylic acid cycle. Indeed, ARID1A-mutant OCCCs were hyper-sensitive to inhibition of SLC38A2. In addition, SLC38A2 inhibition enhanced chimeric antigen …

Pengaruh Penerapan Teknik Relaksasi Otot Progresif Berbasis Musik Instrumental Terhadap Gejala Stres Kerja Pada Pegawai Di Dinas Kesehatan Kabupaten Probolinggo, Salwa Isna Barlian, Anita Sulistyorini, Marji Marji, Agung Kurniawan

National Journal of Occupational Health and Safety

Work stress symptoms are a condition where there is a mismatch between a person's condition and work demands, resulting in mental (psychological), physical, and behavioral disorders. Government employees are among those who are vulnerable to experiencing work stress symptoms. Based on preliminary study results, the Probolinggo Regency Health Office is one of the type A offices with a high workload, and several employees have been found to experience symptoms of work stress. The purpose of this study was to determine the effect of applying instrumental music-based progressive muscle relaxation techniques on work stress symptoms in employees at the Probolinggo Regency …

Hubungan Repetitive Motion, Beban Kerja, Shift Kerja, Dan Kualitas Tidur Dengan Kelelahan Kerja Pada Petugas Aviation Security, Cindy Puspita Sari, Anita Sulistyorini, Marji Marji, Erianto Fanani, Tika Dwi Tama

National Journal of Occupational Health and Safety

The aviation sector is one of the work areas that requires the implementation of Occupational Health and Safety (OHS). Work in the aviation sector also presents various risks, one of which can occur in work accidents caused by fatigue. Based on preliminary studies conducted on Aviation Security Officers (AVSEC), there are symptoms of work fatigue. The study aims to determine the relationship of repetitive motion, workload, work shifts, and sleep quality with job fatigue in AVSEC officers. The research used a quantitative observational study with an analytic design through a cross-sectional approach with a total of 76 AVSEC officers. The …

Faktor-Faktor Yang Berhubungan Dengan Kecelakaan Kerja Pada Operator Dump Truck Di Pt. X Kabupaten Kutai Timur, Anindya Sashi Kirana, Muhammad Sultan, Ida Lestari, Iwan Muhamad Ramdan, Dewi Novita Hardianti

National Journal of Occupational Health and Safety

Coal mining is one of the industries that has a high level of danger and risk of work accidents. In 2023, in PT X department Z there were 36 work accidents with the most units occurring in the dump truck unit. The purpose of this study was to determine the factors associated with work accidents in dump truck operators at PT X East Kutai Regency in 2025. This study used a cross sectional study design with 78 respondents who were dump truck operators taken by stratified random sampling. Data collection using questionnaires and CMR (Compliance Monitoring Report) observation sheets that …

Arterial Stiffness In Heart-Healthy Indigenous Tsimane Forager-Horticulturalists, Tianyu Cao, Edhitt Cortez Linares, Raul Quispe Gutierrez, Daniel Eid Rodriguez, Jesus Bani Cuata, Michael I. Miyamoto, Christopher Von Rueden, Daniel K. Cummings, Paul L. Hooper, Benjamin C. Trumble, Jonathan Stieglitz, Randall C. Thompson, Gregory S. Thomas, Hillard S. Kaplan, Daniel A. Duprez, David R. Jacobs Jr., Michael Gurven

ESI Publications

Background

Methods

Energy Expenditure And Obesity Across The Economic Spectrum, Amanda Mcgrosky, Amy Luke, Leonore Arab, Kweku Bedu-Addo, Alberto G. Bonomi, Pascal Bovet, Soren Brage, Maciej S. Buchowski, Nancy Butte, Stefan G. Camps, Regina Casper, Daniel K. Cummings, Sai Krupa Das, Sanjoy Deb, Lara R. Dugas, Ulf Ekelund, Terrence Forrester, Barry W. Fudge, Melanie Gillingham, Annelies H. Goris, Michael Gurven, Catherine Hambly, Annemiek Joosen, Peter T. Katzmarzyk, Kitty P. Kempen, William E. Kraus, Wantanee Kriengsinyos, Rebecca Kuriyan, Robert F. Kushner, Estelle V. Lambert, Christel L. Larsson, William R. Leonard, Nader Lessan, Marie Löf, Corby K. Martin, Anine C. Medin, Marian L. Neuhouser, Kirsi H. Pietilainen, Guy Plasqui, Ross L. Prentice, Susan B. Racette, David A. Raichlen, Eric Ravussin, Leanne Redman, Rebecca M. Reynolds, Eric B. Rimm, Susan Roberts, Asher Y. Rosinger, Mary H. Samuels, Srishti Sinha, J. Josh Snodgrass, Eric Stice, Ricardo Uauy, Samuel S. Urlacher, Jeanine A. Verbunt, Bruce Wolfe, Brian Wood, Xueying Zhang, Alexia J. Murphy-Alford, Cornelia J. Loechl, Jennifer Rood, Hiroyuki Sagayama, Dale A. Schoeller, Klaas R. Westerterp, William W. Wong, Yosuke Yamada, John R. Speakman, Herman Pontzer, The Iaea Dlw Database Consortium

ESI Publications

Global economic development has been associated with an increased prevalence of obesity and related health problems. Increased caloric intake and reduced energy expenditure are both cited as development-related contributors to the obesity crisis, but their relative importance remains unresolved. Here, we examine energy expenditure and two measures of obesity (body fat percentage and body mass index, BMI) for 4,213 adults from 34 populations across six continents and a wide range of lifestyles and economies, including hunter-gatherer, pastoralist, farming, and industrialized populations. Economic development was positively associated with greater body mass, BMI, and body fat, but also with greater total, basal, …