Altered Patterning Of Neural Activity In A Neuropathology, Clarissa Hoffman, Jingheng Cheng, Rodrigo Morales, Daoyun Ji, Yuri Dabaghian

Faculty, Staff and Students Publications

The dynamics of neural circuits and their role in mediating cellular and organismal phenomena remain poorly understood, despite numerous efforts to dissect these processes through precise instantaneous measurements or longer-time averages and approximations. We use an alternative approach: we investigate these dynamics at the system's mesoscale by analyzing spike trains and waveforms. These extended activity patterns carry robust, tractable information, are highly responsive to physiological specifics, and enable detailed tracking of circuit behavior. In particular, this methodology allows for characterizing the functionality of tau-pathology-afflicted hippocampal circuits and identifying circuit-level abnormalities that are missed by through traditional analyses. In healthy mice, …

Clinical Outcomes In Patients With Schizophrenia Treated With Long-Acting Injectable Vs Oral Antipsychotics: A Naturalistic Study, Francesca Bardi, Lorenzo Moccia, Georgios D Kotzalidis, Gianluca Boggio, Andrea Brugnami, Greta Sfratta, Delfina Janiri, Gabriele Sani, Alessio Simonetti

Faculty, Staff and Students Publications

Background/Objectives: Long-acting injectable antipsychotics (LAIs) represent a significant advancement in the treatment of schizophrenia (SCZ), particularly for improving adherence and long-term outcomes. This study aimed to assess the clinical outcomes of patients receiving atypical LAIs compared to those on various oral antipsychotics over a one-year follow-up in a naturalistic setting.

Methods: Sixty patients with SCZ were subdivided in two groups, those receiving LAIs (n = 25) and those receiving oral antipsychotics (n = 35). The groups were comparable for age, gender, educational attainment, employment status, marital status, smoking habits, and baseline SCZ severity, with no differences …

Elimination Of Hiv Reservoirs Harboring Intact Proviruses, Min Li, Khanghy Truong, Suman Sharma, Baichao Sun, Min Chen, Jason T Kimata, Jin Wang

Faculty, Staff and Students Publications

Background: Human immunodeficiency virus (HIV) establishes persistent infection by integrating its proviral DNA into the host genome. While most integrated proviruses are defective, a small portion of proviruses are intact that represent a major obstacle to achieving an HIV cure. We have designed an approach for selective elimination of host cells harboring replication-competent HIV (SECH), through inhibition of autophagy and anti-apoptotic molecules during viral reactivation. However, the effects of SECH on the dynamics of intact and defective HIV provirus remain unclear.

Methods: We isolated DNA from HIV-infected samples after SECH treatments. We analyzed HIV-1 proviruses in these samples by intact …

Spase: Spatially Resolved Pathology Scores Using Optimal Transport On Spatial Transcriptomics Data, Mohammad Nuwaisir Rahman, Mohammed Abid Abrar, Vikram Rakesh Shaw, James F Martin, M Saifur Rahman, Md Abul Hassan Samee

Faculty, Staff and Students Publications

Pathological events often impact tissue regions in a spatial variable manner, making it challenging to identify therapeutic targets. Spatial transcriptomics (ST) is a powerful technology to map spatially variable molecular mechanisms, yet suitable analytical methods have been lacking. We introduce SPaSE (Spatially-resolved Pathology ScorE), an optimal transport-based algorithm to compare ST data from diseased and control tissues. SPaSE computes a “pathology score” for each spot in the diseased sample, quantifying the pathological impact at that spot. In post-MI (myocardial infarction) mouse hearts, these scores delineated zones that matched independent expert annotations. Modeling pathology scores from gene expression revealed signatures predictive …

Twenty-Five Year Trend In Antipsychotic Medication Prescribing In England: Challenges And Opportunities, Rohit Shankar, Hannah Newman, David Branford, Richard Laugharne, Richard Byng

Peninsula Medical School

BackgroundAntipsychotics are primarily indicated for psychotic disorders. There is increasing concern regarding their potential overuse for other conditions.AimsTo examine the change in the number of community prescriptions and corresponding costs for antipsychotics per head of population over 25 years (1998–2022) in England.MethodThe data for 1998–2022 were obtained from two separate resources from the OpenPrescribing database: from 1998 to 2016 from their long-term trends data-set; and for 2017–2022 from the monthly medication prescribing data. The relevant British National Formulary subcategories 4.2.1 ‘antipsychotic drugs’ and 4.2.2 ‘antipsychotic depot injections’ were selected. The annual differences in prescriptions and the mean average annual increase …

Specialty Grand Challenge: Existing Issues And Emerging Frontiers In Renal Endocrinology, A. T. M. Emdadul Haque, Mohammed S. Razzaque

School of Medicine Publications

We are currently in an exciting time to advance the field of renal endocrinology. There has never been a more favorable time to study the molecular and cellular mechanisms underlying renal hormone functions in physiology, pharmacology, and pathophysiology. The availability of advanced research tools provides unique opportunities to dissect the complex regulatory roles of renal hormones. The kidneys are vital organs in the human body; each one is composed of approximately one million functional nephrons. Understanding the precise roles and regulation of kidney-derived hormones and hormones that exert endocrine effects on the kidneys will help in preventing or delaying various …

Examination Of The Criterion-Related Validity Of The Scales For Assessing Emotional Disturbance – 3rd Edition, Corey Pierce, Jacqueline Huscroft-D'Angelo, Jessica Wery, Brad Uhing, Jodie Martin, Kara Loftin

Journal of Educational Research and Innovation

In this study, we sought to determine if the Scales for Assessing Emotional Disturbance – Third Edition (SAED-3; Epstein et al., 2020) demonstrated adequate validity using criterion validation techniques. The associations between the SAED-3 subscales and composite scores were examined in relation to similar scores from the Behavior Assessment System for Children – Second Edition (BASC-2; Reynolds & Kamphaus, 2004) and the Strengths and Difficulties Questionnaire (SDQ; Goodman, R., 1997). SAED-3 ratings were conducted with either the BASC-2 or SDQ with 121 students ages 6 to 17 years. The overall criterion prediction evidence of …

Book Review: The Olympics That Never Happened: Denver '76 And The Politics Of Growth, Samuel M. Clevenger

Global Sport Business Journal

The issue of economic growth and its historical ties to modern sport is of central importance to contemporary sport business researchers. After all, considering that the growth-driven sport industry is increasingly trying to balance improving the sustainability of their present practices and facilities with maintaining its emphasis on expansion, accumulation, and revenue generation–resulting in organizations like the International Olympic Committee (IOC) engaging in “greenwashing” (Boykoff, 2025)–we (meaning sport researchers) need plentiful work that takes seriously the issue of economic growth and its impacts on the decision-making of sporting organizations. Adam Berg’s recent book The Olympics That Never Happened: Denver ‘76 …

Bridging Cultures Beyond Borders: An Experiential Education Program For Exploring Third Places In Global And Local Contexts, Rachel Desmarais

Capstone Collection

While experiential education has gained popularity in recent years, options for experiential education opportunities unrelated to an international internship or service-learning program are relatively limited. Furthermore, opportunities to learn through engaging with third places in both one’s home community and host community are quite limited. The following proposed program aims to fill this gap by focusing on immersion in third places in one’s home community and the host community of Madrid, Spain. This program is also designed to address the need for experiential education that goes beyond traditional structures, offering students the chance to engage deeply with their environments. It …

Seoul’S Soul: A Study Of Drag Culture’S Influence On Queer Young Adult’S Education In South Korea, Ian Sollender

Capstone Collection

Drag performance has long been considered a site of artistic expression, political resistance, and community-building within LGBTQ+ spaces. This capstone research project explores the educational impact of drag culture in Seoul, South Korea, with a particular focus on how drag performances serve as a pedagogical and educational tool that challenges gender norms, fosters queer community, and provides a platform for political discourse. Through qualitative analysis of participant observation, bilingual Korean and English survey responses, and in-depth English interviews with drag performers, performance organizers, and audience members, this research highlights the ways in which drag can function as a site of …

Flow-Nalytics: A Monitoring, Evaluation And Learning Capacity Assessment Of A Menstrual Health Education Organization, Chanel Jimenez

Capstone Collection

This capstone project explored the monitoring, evaluation and learning (MEL) capacities of an organization in Colombia that promotes comprehensive menstrual education. The current contexts surrounding menstrual health and hygiene management (MHHM) globally and in Colombia, the relevant policy environment and the MEL context of MHHM were featured prominently in the literature review. Concepts such as feminist pedagogy theory and the term “empowerment” were also explored.

The project methodology consisted of a desk review, facilitated discussions and observed workshops with the organization founder, which used the pseudonym, Tenara. In collaboration with the organization’s founder, the author identified various findings, challenges and …

Shining In Times Of Crisis: How Refugee Women Display Leadership And Transform Hardship, Laura Iorg

Capstone Collection

Abstract

There are currently approximately 122.6 million people displaced globally (UNHCR, 2024). This figure includes 43.7 million refugees (UNHCR, 2024). Nearly half of them are women. This qualitative study examined the following questions: How do women manifest leadership and agency in refugee situations? Subquestion: How do women contribute to peace, transformation, and healing through that leadership and agency? Five different individuals who had worked with women refugees for at least two years were recruited for the study. Two data collection instruments were employed: a preliminary survey and a structured interview. The study focused on the lived experiences of refugee women …

Let Us Break Bread Together: A Historical Analysis Of African American Chefs’ Influence On American Gastronomy, Danielle S. King

Capstone Collection

This Capstone project examines the historical impact of African American chefs on American gastronomy, highlighting their substantial contributions to the nation's culinary heritage from 1619 to 2024. By employing Jessica B. Harris's book High on the Hog as a foundation, the research identifies a critical gap in existing study abroad programs: the Black diaspora within the United States. The proposed four-week educational program aims to immerse participants in African American culinary heritage across four culturally rich cities: Charleston, South Carolina; New Orleans, Louisiana; Chicago, Illinois, and Oakland, California. With a community cultural wealth framework, the program integrates historical research, hands-on …

A Hybrid Ai-Powered Voice-Enabled Medical Practice Assistant With Dynamic Triage Routing And Multi-Modal Patient Interaction, Patrick Proctor

Defensive Publications Series

We present a novel implementation of a voice-enabled medical practice virtual assistant that combines real-time speech processing, intelligent medical triage routing, and multi-modal patient interaction capabilities. Our system employs a hybrid AI architecture that dynamically selects between different language models based on query complexity classification, reducing operational costs while maintaining high-quality responses for complex medical inquiries. The system incorporates a deterministic medical triage decision tree based on established nursing protocols, enabling automated routing of urgent cases while maintaining HIPAA compliance. Additionally, we introduce an innovative multi-step interaction pattern for location-aware services, seamlessly transitioning between voice input, location detection, and turn-by-turn …

Assessing The Lgbtq+ Beliefs, Behaviors, And Competency Of Nutrition Professionals: A Mixed-Methods Study, Anthony Dissen, Christina Riccardo, Liam Oliver Lair

Journal of Dietetic Education

Lesbian, gay, bisexual, transgender, and queer/questioning (LGBTQ+) individuals often experience disproportionate levels of physical and mental health issues including nutrition-specific issues such as eating disorders, body dysmorphia, and food insecurity related to psychological distress from discrimination and stigmatization. This study sought to understand nutrition professionals’ LGBTQ+ competence, beliefs, and behaviors. Researchers distributed 2 data collection tools to registered dietitian nutritionists (RDNs): the Gay Affirmative Practice Scale (GAP-Scale) and the LGBT Competency Assessment Tool (LGBT-CAT). Data from the GAP-Scale were numerically scored using a 5-point Likert scale, and data from LGBT-CAT were scored on a scale of 0 to 3 points. …

Examining Weight Bias Attitude Changes After Exposure To A Brief Photovoice Assignment, Gretchen L. George, Hillary L. Roberts, Kristin Rose, Madison Clemens, Kate G. Burt

Journal of Dietetic Education

Weight bias is present among pre-health professional students (e.g., nutrition, dietetics, nursing, physical therapy, medicine). Educators need support and guidelines about how to enhance learning through engaging assignments while also meeting accreditation requirements. This pilot study examined the impact of an innovative weight bias assignment using photovoice and reflection within existing nutrition education courses, measured through pre-post assessments from the Fat Attitudes Assessment Toolkit. While not all subscales showed significant change, improvements in the Fat Acceptance and Attribution Complexity Composites suggest these methods may be effective in shifting attitudes about fatness. Further research is needed to assess the long-term impact …

Development Of Dietetics Students’ Skills And Self-Efficacy In The Nutrition Care Process, Kristen Heitman, Marcia Nahikian-Nelms, Holly Estes-Doetsch, Kristen M. Roberts, Jennifer A. Garner, Julie Kennel, Christopher A. Taylor

Journal of Dietetic Education

The Nutrition Care Process (NCP) is a systematic framework for providing nutrition care and a cornerstone of dietetics practice. Dietetics education relies on development of skills to achieve competence and demonstrate readiness for practice. The relationship between development of fundamental skills and self-efficacy among dietetics students preparing for clinical practice remains unclear. The purpose of this study was to examine the development of dietetics students’ skills in NCP documentation and their self-efficacy in performing the skills over one academic year. Student nutrition notes (n = 120 notes, n = 30 students) from standardized patient encounters were evaluated for quality using …

Burnout And Turnover Among Program Directors In Acend-Accredited Registered Dietitian Nutritionist Programs, Heather Frazier, Patricia Grace-Farfaglia

Journal of Dietetic Education

Background: Knowledge about program director burnout in ACEND-accredited registered dietitian nutritionist programs is severely limited. Objective: To measure the changes in program director burnout and turnover over a two-year period. Methods: An online questionnaire was distributed to program directors via e-mail in 2021 and 2023. The validated Maslach Burnout Inventory-Educators Survey (MBI-ES) was used to measure burnout, which had three scales: emotional exhaustion, depersonalization, and personal accomplishment. Demographic and program information was also obtained. Results: Over the two-year period, program directors scores for emotional exhaustion (p < 0.001) and depersonalization (p < 0.001) significantly worsened. Interestingly, personal accomplishment scores significantly improved (p < 0.001) during the same time frame. Sixty-six percent of program directors in 2023 reported consideration for leaving their position in the next 5 years, which increased from 58%. Since 2021, 29.9% Didactic Program in Dietetics directors, 28.8% Dietetic Internship directors, and 37.5% Coordinated Program in Dietetics directors have resigned. Conclusion: Program directors show increased signs of burnout. Efforts are needed to investigate ways to support program directors to reduce burnout and increase retention of program directors.

Integrated Advanced Education Supports Future Registered Dietitian Nutritionists’ Breastfeeding Self-Efficacy In Practice, Crystal C. Douglas, Simone Camel

Journal of Dietetic Education

Objective: Evaluate the effectiveness of graduate-level breastfeeding and lactation management education that includes didactive and active learning components on future RDNs’ knowledge, attitudes, and self-efficacy. Design: A pre-and post-test design, utilizing a 41-item pre-intervention survey, learning modules, and a 35-item post-intervention survey. Setting: Three U.S. public universities located in Texas, Louisiana, and Arkansas. Participants: Graduate-level dietetic internship students. Intervention: Four advanced education modules (2 didactive; 2 active learning) developed by Registered Dietitian Nutritionists. Main outcome measures: Gains in breastfeeding knowledge, attitudes, and self-efficacy to assist with breastfeeding education and problem-solving using validated and newly developed survey items. Analysis: Descriptive statistics, …

Sense Of Belonging In The Profession And Program Of Study Among Nutrition And Dietetics Students, Jessica Torro, Melissa Masters, Rachel C. Sinley, Jesse Lunsford, Heidi Masching, Miranda Chen Musgrove

Journal of Dietetic Education

Sense of belonging may positively impact student performance, especially in marginalized groups. This study aimed to examine sense of belonging among a diverse group of nutrition and dietetics students. An online survey investigated students’ feelings of belonging, isolation, and connection to the field of nutrition and dietetics and department of study. The survey was distributed through email to the nutrition and dietetics student body in the Department of Nutrition at Metropolitan State University of Denver. Quantitative data were analyzed as count and percentage. Overall sense of belonging scores were calculated as an average on a 5-point scale (1-strongly disagree to …

Cover, Table Of Contents, About The Journal, Diana Cuy Castellanos, M Elizabeth (Beth) Miller

Journal of Dietetic Education

No abstract provided.

Editors' Message, Diana Cuy Castellanos, M Elizabeth (Beth) Miller

Journal of Dietetic Education

No abstract provided.