Digital Commons Network^™

2025, 1(20)

Journal of Marketing and Consumer Behaviour in Emerging Markets

Full Issue 2025, 1(20)

Detection Of Neuron Derived Cfdna In Blood Plasma: A New Diagnostic Approach For Neurodegenerative Conditions, Chad Alan Pollard

Theses and Dissertations

Neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS) are characterized by the progressive loss of distinct neuronal subtypes, yet current diagnostic tools are either invasive, limited in resolution, or poorly suited for early detection and longitudinal monitoring. This dissertation began with a proof-of- concept study using bisulfite-PCR at a neuron-enriched locus to detect cortical neuron-derived cell-free DNA (cfDNA) in AD plasma samples, establishing the potential of cfDNA as a marker of neuronal injury. Building on these preliminary findings, a novel framework was developed utilizing Oxford Nanopore Technologies (ONT) to profile genome-wide native DNA …

State-Level Immigrant Policies And Diabetes Prevalence In Latino And Asian American Groups: A Weighted Multilevel Analysis, Md Towfiqul Alam, Jennifer Toller Erausquin, Erica Payton, Elizabeth Vásquez, Sandra Echeverria

Faculty Scholarship

Introduction: Growing literature has shown that immigrant-related policies influence population health by limiting or enhancing immigrants’ rights. However, less is known about the role of state-level immigrant policies shaping chronic health conditions such as type 2 diabetes (T2DM). This cross-sectional study examined the association between state-level immigrant policies (both criminalising and inclusive) and prevalence of T2DM among individuals of Latin American and Asian American origin.

Method: We included adults aged 18+years sampled in the 2014–2018 behavioral risk factor surveillance system (BRFSS) (n=201 824), a survey design that allows the calculation of state-level estimates. Using existing policy measures, states …

Beyond Translating Cultures: Organizational Cultural Brokering And Latin@/E/X Community Resilience After The "Mobile Home Parks" Fire, Christine Atalie Da Rosa

Dissertations and Theses

As wildfires increase in frequency and severity in rural communities, disaster management agencies are seeking to collaborate with community-based organizations (CBOs) working with rural, low-income Latin@/e/x communities to build wildfire resilience. This qualitative case study examines the critical role of CBOs rooted in their local, predominately low-income Latin@/e/x communities as cultural brokers in supporting Latin@/e/x wildfire survivors following the 2020 "Mobile Home Parks" Fire in a rural county in Oregon. Drawing from 23 semi-structured interviews, three focus groups, a review of relevant documents, and participant observations, the research investigates how Latin@/e/x CBOs navigated the complex cultural landscape between wildfire survivors …

I, As In We, Cj Maruyama

Dissertations and Theses

I, as in We is a hybrid collection of poems, essays, fictional letters, documents, and photographs through which the author revisits ancestors and explores their multiracial roots. Drawing on stories, interviews and research grounded in the Japanese American experience, the collection develops a call-and-response polyvocality that spans generations and geographies. In its use of white space, form experimentation, and tonal shifts, the work confronts the fluid, often ambiguous boundaries that shape identity. The compiled written and visual materials evolve into an original document--one that reaches toward heritage, belonging, and truth.

A Web Application For Generating Argument Maps For Essays Using Llms, Alexis R. Chalmers

Theses

Argumentative writing is a critical skill that strengthens students’ reasoning, communication, and analytical abilities. However, maintaining a clear and organized argument structure while writing can be challenging. Argument maps — visual diagrams which explicitly show an argument’s structure — have been shown to improve students’ writing, but are rarely used outside of the planning stage of an essay due to the time and effort required to create them. Automatically generating argument maps from student essays helps students to evaluate the structure of their argument as they write and makes identifying unsupported claims visible. To evaluate whether large language models (LLMs) …

Brain Functional Connectivity Correlates Of Autism Diagnosis And Familial Liability In 24-Month-Olds, John R Pruett Jr, Alexandre A Todorov, Muhamed Talovic, Tomoyuki Nishino, Steven E Petersen, Savannah Davis, Lyn Stahl, Kelly N Botteron, Natasha Marrus, Robert C Mckinstry, William D Shannon, Abraham Z Snyder, Et Al.

2020-Current year OA Pubs

BACKGROUND: fcMRI correlates of autism spectrum disorder (ASD) diagnosis and familial liability were studied in 24-month-olds at high (older affected sibling) and low familial likelihood for ASD.

METHODS: fcMRI comparisons of high-familial-likelihood (HL) ASD-positive (HLP, N = 23) and ASD-negative (HLN, N = 91), and low-likelihood ASD-negative (LLN, N = 27) 24-month-olds from the Infant Brain Imaging Study (IBIS) Network were conducted, employing object oriented data analysis (OODA), support vector machine (SVM) classification, and network-level fcMRI enrichment analyses.

RESULTS: OODA (alpha = 0.0167, 3 comparisons) revealed differences in HLP and LLN fcMRI matrices (p = 0.012), but none for HLP …

Cdc1s Promote Atherosclerosis Via Local Immunity And Are Targetable For Therapy, Miguel Galán, Suin Jo, Tian-Tian Liu, Kenneth M. Murphy, Et Al.

2020-Current year OA Pubs

BACKGROUND: Atherosclerosis is characterized by immune cell accumulation in the arterial wall and adaptive CD4

METHODS: We tested atherosclerosis in

RESULTS: Expansion of DCs in

CONCLUSIONS: Using state-of-the-art strategies, our results establish that cDC1s have a proatherogenic role in atherosclerosis by boosting CD4

Ud In The News July 12-18, University Of Dayton

News Releases

A pair of publications listed the schools of engineering and business among the best in the nation. Local media highlighted biology research, legal expertise, and the transition from outgoing board chair Rick Omlor to new board chair Deb Tobias.

Atopy-Related Immune Profiles Are Subject To Genetic Influence As Evaluated Using School-Aged Twin Pairs, Jonatan Leffler, James F. Read, Danny Mok, Michael Serralha, Anthony Bosco, Patrick G. Holt, Richard Saffery, Deborah H. Strickland

Research outputs 2022 to 2026

The interaction of genetic and environmental contributions to immunological traits and their association with atopic disease remain unclear. Flow cytometry and in vitro cytokine responses were used to characterize immune profiles from 93 school-aged twin pairs. Using an established twin pair analytical strategy, the genetic and environmental influences on immunological traits were evaluated, along with their association with atopy. Our findings suggest strong genetic influence on several traits, particularly B cell abundance. In contrast, cytokine responses from in vitro stimulations appeared mainly shaped by environmental exposures. Regarding associations with atopy, greater abundance of both B cells and basophils were observed …

Field Width Comparison Of The Photon Beams 6 Mv And 10 Mv Coming Out Of The Radiotherapy Linear Accelerator, Basma Saber Lazem, Ikram Jumaa Hassan, Basim Khalaf Rejah, Hyam Khalaf, Mostafa Yuness Abdelfatah Mostafa

Baghdad Science Journal

The current study aims to measure and compare the field width emerging from the radiotherapy linear accelerator in different directions, three dimensions were chosen to measure the field width in an orderly (inline, cross line, diagonal A and B) manner. The 10 Mv and 6 Mv photon beam energies were used, and the Star Track device was adopted to measure the field width in different directions. The radiotherapy linear accelerator at the Baghdad Center for Radiation Therapy and Nuclear Medicine was used every week five weeks. The results recorded that when the energy increased 10 Mv, there was an increase …

The Impact Of Inorganic Nitrate On Endothelial Function: A Systematic Review Of Randomized Controlled Trials And Meta-Analysis, Esther Muriuki

School of Health Professions

Context: Inorganic nitrate is an exogenous source of nitric oxide, an established regulator of vascular homeostasis via the nitrate-nitrite-nitric oxide pathway. Here, we evaluate the impact of inorganic nitrate on endothelial function, a risk factor for cardiovascular disease. Objective: A systematic review of the existing literature and meta-analysis was performed. Trials testing inorganic nitrate compared with a control were selected and the change in forearm endothelial function (as assessed by flow-mediated dilatation [FMD]) were included. Data Sources: The following databases were searched: Medline, Web of Science, and Scopus. Data Extraction: and Analysis Standardized mean differences in %FMD were pooled using …

Reimagining Information Literacy In The Age Of Artificial Intelligence: A Nudge In The Right Direction, Kay Coates, Lili Li

University Libraries: Faculty Presentations

No abstract provided.

The Flash Technique As An Effective Low-Intensity Intervention For Migrants At The U.S. Point Of Entry, Selma D. Yznaga, Sik-Lam Wong, Suzanne Maniss

Counseling Faculty Publications

Migrants often face severe trauma before and during their journey, leading to mental health challenges such as post-traumatic stress disorder and acute stress. This study explores the Flash Technique (FT) as a one-time intervention for newly arrived migrants. Twelve healthcare professionals and 11 student interns trained in FT provided interventions to 55 migrants, who showed substantial improvements in subjective units of distress scores. The findings highlight the efficacy of a low-intensity intervention in a humanitarian context, which can serve to mitigate the long-term psychological impact of trauma.

Stoners, Walnuts, Stockings, And Guns: A Material History Of Modern Firearms, Aiden Mashaal

History Summer Fellows

The study of firearms as material objects is notably rare among academic historians. It is relegated mainly to the pages of firearms magazines and carried out by journalists, gun collectors and enthusiasts, and gun manufacturers. Although they provide valuable information to readers outside of academia, it is long past due to observe the history of guns according to scholarly standards. This study provides a concise analysis of firearms history, focusing on the materials used in the manufacture of modern firearms—aluminum alloy and polymers. It explores the successes and failures of guns that used such materials in order to explain how …

Secondary Malignancies In Patients With Meningioma: A Surveillance, Epidemiology, And End Results Data Analysis, Maxwell W. Pickles, Thomas Z. Rohan, Shreya Vinjamuri, Nikolaos Mouchtouris, Roger Murayi, David P. Bray, James J. Evans

Department of Neurosurgery Faculty Papers

BACKGROUND: The risk of secondary primary malignancies (SPMs) in meningioma patients is not well understood. In this unidirectional analysis, we evaluated the risk of SPMs occurring following a primary diagnosis of meningioma.

METHODS: The Surveillance, Epidemiology, and End Results (SEER-17) database (2000-2020) was used to identify 124,769 meningioma patients from a total of 9,208,295 cancer cases. Standardized incidence ratios (SIRs) were calculated using SEER's statistical analysis package to evaluate SPM risk. Basic demographic and treatment information was collected as well.

RESULTS: Of the 124,769 patients, 11,411 (9.2%) received diagnoses of an SPM, which correlates to a higher risk than the …

Granulocyte-Colony Stimulating Factor Effects On The Mesolimbic Dopamine Circuitry And Adaptations With Chronic Ethanol Exposure, Rachel Ji-Hyae Campbell

Theses and Dissertations

The mesolimbic dopamine (DA) system contributes to reward and reinforcement learning for ethanol (EtOH). The nucleus accumbens (NAc) receives DA input from the ventral tegmental area (VTA) encoding rewarding information. Acute EtOH increases NAc DA levels, and this DA response is attenuated with chronic EtOH exposure. Furthermore, chronic EtOH results in reduced DA release, increased DA clearance and presynaptic D2-type auto-receptor sensitization. Further research into EtOH-induced neural adaptations that modulate NAc DA release is explored herein, including changes in cholinergic interneurons (CIN), which are known regulators of DA transmission. One potential class of regulators are immune related cytokines, that can …

Impact Of Sars-Cov-2 On Healthcare And Essential Workers: A Longitudinal Study Of Promis-29 Outcomes, Jocelyn Dorney, Imtiaz Ebna Mannan, Caitlin Malicki, Lauren E. Wisk, Joann Elmore, Kelli N. O'Laughlin, Dana Morse, Kristyn Gatling, Michael Gottlieb, Michelle Santangelo, Michelle L'Hommedieu, Nicole L. Gentile, Sharon Saydah, Mandy J. Hill, Ryan Huebinger, Katherine Riley Martin, Ahamed H. Idris, Efrat Kean, Kevin Schaeffer, Robert M. Rodriguez, Robert A. Weinstein, Erica S. Spatz, Inspire Group

Department of Emergency Medicine Faculty Papers

IMPORTANCE: The mandatory service of essential workers during the COVID-19 pandemic was associated with high job stress, increased SARS-CoV-2 exposure, and limited time for recovery following infection. Understanding outcomes for frontline workers can inform planning for future pandemics.

OBJECTIVE: To compare patient-reported outcomes by employment type and SARS-CoV-2 status.

DESIGN: Data from the INSPIRE registry, which enrolled COVID-positive and COVID-negative adults between 12/7/2020-8/29/2022 was analyzed. Patient-reported outcomes were collected quarterly over 18 months.

SETTING: Participants were recruited across eight US sites.

PARTICIPANTS: Employed INSPIRE participants who completed a short (3-month) and long-term (12-18 month) survey.

EXPOSURE: SARS-CoV-2 index status and …

Electrochemical Immunosensor Using Cooh-Functionalized 3d Graphene Electrodes For Sensitive Detection Of Tau-441 Protein, S. Nazir, M. Dogan, Y. Wei, G. Pan

School of Engineering, Computing and Mathematics

Early diagnosis of Alzheimer’s disease (AD) is essential for effective treatment; however current diagnostic methods are often complex, costly, and unsuitable for point-of-care testing. Graphene-based biosensors offer an alternative due to their affordability, versatility, and high conductivity. However, graphene’s conductivity can be compromised when its carbon lattice is oxidized to introduce functional groups for biomolecule immobilization. This study addresses this challenge by developing an electrochemical immunosensor using carboxyl-modified commercial graphene foam (COOH-GF) electrodes. The conductivity of graphene is preserved by enabling efficient COOH modification through π–π non-covalent interactions, while antibody immobilization is optimized via EDC-NHS carbodiimide chemistry. The immunosensor detects …

Longitudinal Changes In Infant Attention-Related Brain Networks And Fearful Temperament, Courtney A. Filippi, Alice Massera, Jiayin Xing, Hyung G. Park, Emilio A. Valadez, Jed T. Elison, Dana Kanel, Daniel Samuel Pine, Nathan A. Fox, Anderson M. Winkler

Human Genetics Publications

Background: Anxiety disorders may partly stem from altered neurodevelopment of attention-related networks. Neonatal alterations in resting-state functional connectivity (rsFC) among the dorsal attention network (DAN), frontoparietal network (FPN), salience network (SN), and default mode network (DMN) relate to fearful temperament, a risk marker for anxiety. Nevertheless, few studies have examined the development of these networks beyond the first months of life, particularly in fearful infants. In this study, we examined how changes in these networks during the first 2 years of life relate to fearful temperament.

Methods: Using data from the Baby Connectome Project (from 180 infants across 396 sessions), …

Breaking The Odds: A Gendered Analysis Of Women And Gambling Behaviors, Rowland Edet

UNLV Gaming Research & Review Journal

Gambling is increasingly recognized as a complex public health issue with wide-ranging implications for individuals, families, and communities. While traditionally male-dominated, recent shifts reveal a growing participation among women, facilitated by gender-specific gambling products, targeted marketing, and evolving societal norms. This paper critically examines the prevalence, motivations, and harms associated with gambling among women, drawing on theoretical perspectives such as social capital theory, cultural geography, and gender role theory. By synthesizing existing literature, this review highlights distinct gendered patterns in gambling behaviors, including the use of gambling as a coping mechanism for stress, isolation, and caregiving burdens, and the role …

Prenatal Maternal Mood Instability And Child Externalizing Problems: An Ecological Momentary Assessment Study, Sophie G. Srivastava, Curt A. Sandman, Elysia Poggi Davis, Laura M. Glynn

Psychology Faculty Articles and Research

This study examines whether exposure to affect fluctuations during fetal development have implications for child psychopathology. To evaluate maternal mood instability, participants (N = 154) completed Ecological Momentary Assessment (EMA) eight times per day across three days at 15-, 25-, and 35-weeks' gestation, and then at two months postpartum. The EMA measured depressive symptoms (Center for Epidemiologic Studies Depression Scale), anxiety (Profile of Mood States), and stress (Perceived Stress Scale). Mood instability was quantified by calculating root mean square of successive differences (RMSSD), which captures both variability and temporal dependency of mood states. When the children were 3 years …

Staff Education To Improve Preceptors’ Knowledge Base To Adapt Teaching Methods Across Generations, Lucretia Dennise Sanders

Walden Dissertations and Doctoral Studies

Today’s nursing workforce consists of individuals from multiple generational cohorts, which creates a dynamic mix of nurses whose behavior and work reflect the cultural and historical events that shaped their generation. As the nursing workforce becomes increasingly multigenerational, nurse educators and leaders face growing challenges in ensuring that onboarding practices meet the needs of diverse learners. In the local organization, leaders and clinical educators observed inconsistencies in preceptorship practices and onboarding experiences, particularly for newly hired nurses. As a result, leaders determined that an educational intervention focused on generational teaching strategies was needed. Thus, the purpose of this Doctor of …

On The Use Of Wearable Continuous Glucose Monitors (Cgms), Jovita Ozonnadi

Walden Dissertations and Doctoral Studies

This DNP project implemented an educational module on the use of continuous glucose monitoring devices (CGM) to increase staff knowledge of diabetic care and glycemic control for the diabetic population in a community healthcare clinic. Diabetes mellitus is a significant health concern that poses a substantial challenge to the community and the American healthcare system with a higher burden of diabetes complications found among the low income, uninsured, and minority populations. Poor glycemic control is a major health issue that significantly increases the risk of developing diabetes-related complications such as heart and kidney diseases, and obesity. The adoption of CGM …

Lgbt Young Adults’ Experience Of Exiting Foster Care, Shaylon Joseph

Walden Dissertations and Doctoral Studies

The scholarly community understands little about the experiences of lesbian, gay, bisexual, and transgender (LGBT) young adults as they transition out of the foster care system. This study explored the lived experiences and difficulties encountered by LGBT young adults after exiting foster care. Grounded in Erikson’s theory of psychosocial development, this qualitative dissertation employed a phenomenological design to interpret how participants made sense of their transitions. Recruitment was conducted through a flyer posted on Facebook and the Department of Children and Family Services; 10 LGBT young adults participated in 60-minute interviews. Using interpretative phenomenological analysis, the study revealed six overarching …

Protein Structure Influences Redox Stability, Oxygen Affinity, And Heat-Induced Denaturation Properties Of Bovine Myoglobin, Hemoglobin, And Cytochrome C, Anuj Sharma, Runnan Li, Silan Bhandari, Surendranath P. Suman, Sadagopan Krishnan, Morgan Pfeiffer, Gretchen Mafi, Ranjith Ramanathan

Animal and Food Sciences Faculty Publications

While past research has predominantly focused on the role of myoglobin in meat color, investigations into the contributions of hemoglobin and cytochrome c are limited. Cytochrome c has the highest redox stability (P < 0.05), followed by myoglobin and hemoglobin. Electrochemistry analysis revealed that cytochrome c has a greater capacity (P < 0.05) to reduce than myoglobin and hemoglobin. Differential scanning calorimetry indicates that cytochrome c was most stable to heat (P < 0.05), while no differences were noted between myoglobin and hemoglobin. Structural analysis noted that greater heat and redox stability of cytochrome c might be attributed to fewer histidine residues (3) and more covalent bonds (4) than myoglobin (13), hemoglobin α (10), and hemoglobin β (6). This study suggests that the amino acid sequence and number of covalent bonds can impact the redox stability and heat-induced denaturation properties of myoglobin, hemoglobin, and cytochrome c.

Image-Based Inference Of Tumor Cell Trajectories Enables Large-Scale Cancer Progression Analysis, Yang Liu, Ling Cai, Ruichen Rong, Shidan Wang, Liwei Jia, Peiran Quan, Qin Zhou, Guanghua Xiao, Yang Xie

Faculty, Staff and Student Publications

Current approaches to estimating cell trajectories, tumor progression dynamics, and cell population diversity of tumor microenvironment often depend on single-cell RNA sequencing, which is costly and resource intensive. To address this limitation, we developed an artificial intelligence (AI) model that leverages cell morphology features and histological spatial organization to classify tumor cell differentiation status, infer cell dynamic trajectories, and quantify tumor progression from hematoxylin and eosin (H&E)-stained whole-slide images. In three independent lung adenocarcinoma cohorts, our AI-based model accurately predicted cell differential status and provided quantifiable measures of tumor progression that were prognostic of patient survival. Spatial transcriptomic integrative analyses …

A Two-Stage Dual-Task Learning Strategy For Early Prediction Of Pathological Complete Response To Neoadjuvant Chemotherapy For Breast Cancer Using Dynamic Contrast-Enhanced Magnetic Resonance Images, Bowen Jing, Jing Wang

Faculty, Staff and Student Publications

Early prediction of treatment response can facilitate personalized treatment for breast cancer patients. Studies on the I-SPY 2 clinical trial demonstrate that multi-time point dynamic contrast-enhanced magnetic resonance (DCEMR) imaging improves the accuracy of predicting pathological complete response (pCR) to chemotherapy. However, previous image-based prediction models usually rely on mid- or post-treatment images to ensure the accuracy of prediction, which may outweigh the benefit of response-based adaptive treatment strategy. Accurately predicting the pCR at the early time point is desired yet remains challenging. To improve prediction accuracy at the early time point of treatment, we proposed a two-stage dual-task learning …

Truncated Ntrk2 Is Induced In Cap1 Endothelial Cells During Mouse Lung Injury-Repair, Celine Shuet Lin Kong, Mitheera V, Jezreel Pantaleón-García, Scott E Evans, Jichao Chen

Faculty, Staff and Student Publications

Pulmonary capillary endothelial cells (ECs) consist of two populations, CAP1 and CAP2; how each population reacts to diverse tissue injury is incompletely understood. Using single-cell multiome and mouse genetics, we characterize the induction and function of a truncated isoform of Ntrk2, Ntrk2-T1, in multiple lung injury models. Upon Sendai parainfluenza infection, Ntrk2-T1 is broadly induced in CAP1s after the initial interferon response, associated with increased intronic chromatin accessibility, and persists for weeks. Ntrk2-T1 ECs arise from CAP1s but not CAP2s-traced by

Ifn-Β Production Promotes Metabolic Rewiring And Protection Against Oxidative Stress In Hepatitis Delta Virus-Infected Hepatocyte Cultures, Olga A Khomich, Patrick Giavalisco, Romain Parent, George S Krasnov, Peter Tessarz, Philip Meuleman, Rani Burm, Natalia F Zakirova, Jennifer Molle, Enkhtuul Batbold, Eyal Gottlieb, Fabien Zoulim, Alexander V Ivanov, Birke Bartosch

Faculty, Staff and Student Publications

Type I interferons are secreted in response to various stimuli and are used as a treatment for many diseases, including infections with the hepatitis B virus (HBV) and its satellite virus, hepatitis delta (HDV). HDV significantly aggravates HBV-mediated liver damage and is - in contrast to HBV - a strong inducer of interferon responses, including IFN-β. As the role of IFN- β in liver metabolism is so far ill explored, we studied its impact on hepatocyte metabolism in HDV-infected cultures. Transcriptome analysis, isotope tracing and functional tests on differentiated, HDV-infected hepatocytes showed reduction of mitochondrial TCA cycle and respiratory activity …