Digital Commons Network^™

Application Of Nova & Denova For Use Of Tee On Patients With E. Faecalis Bacteremia, Chideraa Emma-Ugwuoke, Sameer Rahman, Raul E Davaro Md

Research Scholars

No abstract provided.

Comparing Concussion Recovery Rates Over Time, Francesca Andronic Md, William Kane, Daniele Shollenberger Crnp, Mark Cipolle Md

Research Scholars

No abstract provided.

Impact Of Virtual Visits On Antibiotic Prescribing For Upper Respiratory Infections, Anna Mikulski, Jarrod W. Kile Rphd, Brooke Broczkowski Pharmd, Kathryn Zaffiri Mph, Eric Young Md

Research Scholars

No abstract provided.

Concordance Of Management Of Early And Locally Advanced Esophageal And Esophagogastric Junction Tumors With National Comprehensive Cancer Network Guidelines, Kanchan Gupta, Melissa Kratz Rn, Msn, Aocn, Sean Quinlan-Davidson Md, Savitri Skandan Md

Research Scholars

No abstract provided.

Comparing Concussion Recovery Between Men And Women Using Vision Therapy, Peter Kozloff, Francesca Andronic Md, Daniele Shollenberger Crnp, Mark Cipolle Md

Research Scholars

No abstract provided.

Focused Rapid Assessment Process (Frap) 3.0: A Community-Led, Train-The-Trainer Model For The National Diabetes Prevention Program For Local Spanish-Speaking Adults, Rachel Apiolaza, Carolyn Peterseim Md, Miguel Chuidian Md

Research Scholars

No abstract provided.

Assessing The Inpatient Utility Of Echocardiography And Its Clinical Impact, Briana Prieto, Shuisen Li Do

Research Scholars

No abstract provided.

Long Term Outcomes Of Dermal Substrate Treated Burns And Wounds, Sarvesh Senguttunvan, Sigrid A. Blome-Eberwein Md

Research Scholars

No abstract provided.

Adaptive Bayesian Clinical Trials: The Past, Present, And Future Of Clinical Research, Donald A Berry

Faculty, Staff and Student Publications

Background/Objectives: Decision-analytic Bayesian approaches are ideally suited for designing clinical trials. They have been used increasingly over the last 30 years in developing medical devices and drugs. A prototype trial is a bandit problem in which treating participants is as important as treating patients in clinical practice after the trial.

Methods: This article chronicles the use of the Bayesian approach in clinical trials motivated by bandit problems. It provides a comprehensive historical and practical review of Bayesian adaptive trials, with a focus on bandit-inspired designs.

Results: The 20th century saw advances in Bayesian methodology involving computer simulation. In the …

Distinct Clinicogenomic Features And Immunotherapy Associations In Pulmonary Sarcomatoid Carcinoma: A Multicenter Retrospective Study, Lingzhi Hong, Alessandro Di Federico, Bolun Liu, Alissa J Cooper, Joao V Alessi, Phoebe Clark, Waree Rinsurongkawong, Chingyi Young, Hui Li, Kang Qin, Muhammad Aminu, Valentina Santo, Yasir Elamin, Boris Sepesi, Jeff Lewis, Don L Gibbons, Ara A Vaporciyan, J Jack Lee, Xiuning Le, Jia Wu, Sinchita Roy-Chowdhuri, Mark J Routbort, P Andrew Futreal, John V Heymach, Mark M Awad, Adam J Schoenfeld, Jianjun Zhang, Biagio Ricciuti, Lei Deng, Natalie I Vokes

Faculty, Staff and Student Publications

Introduction: Pulmonary sarcomatoid carcinoma (PSC) is a rare NSCLC subtype with poor prognosis. Outcomes to immune checkpoint inhibitors (ICIs) and genomic features in PSC remain underexplored compared with other NSCLC subtypes.

Methods: Patients from three institutions and the National Cancer Database (NCDB) with metastatic NSCLC treated with ICI alone or with chemotherapy were identified. Clinicogenomics and treatment outcomes were compared across PSC, lung adenocarcinoma (LUAD), and lung squamous cell carcinoma (LUSC).

Results: We analyzed 4841 patients including 165 PSC cases treated with ICI-based therapy from three institutions and 201 PSC from NCDB. In MDACC, 65 (4.3%) were PSC, 1138 (75.1%) …

Human Ipsc-Based Breast Cancer Model Identifies S100p-Dependent Cancer Stemness Induced By Brca1 Mutation, Jingxin Liu, Cai Zhao, Jiahao Chen, Pengguihang Zeng, Qingjian Li, Ranran Dai, Xingqiang Lai, Wenqian Song, Jianing Chen, Xixi Zhu, Xinyi Liu, Jun Sun, Jia Wang, Peihang Fang, Tengfei Wang, Wenjie Chen, Diana Guallar, Nan Cao, Jianli Zhao, Shicheng Su, Andy Peng Xiang, Yi Arial Zeng, Jie Li, Junchao Cai, Dung-Fang Lee, Jinxin Bei, Yongliang Huo, Hai Hu, Shengbao Suo, Dong-Feng Huang, Jin Bai, Junjun Ding

Faculty, Staff and Student Publications

Breast cancer is the most common malignancy in females and remains the leading cause of cancer-related deaths for women worldwide. The cellular and molecular basis of breast tumorigenesis is not completely understood partly due to the lack of human research models which simulate the development of breast cancer. Here, we developed a method for generating functional mammary-like cells (MCs) from human-induced pluripotent stem cells (iPSCs). The iPSC-MCs closely resemble human primary MCs at cellular, transcriptional, and functional levels. Using this method, a breast cancer model was generated using patient-derived iPSCs harboring germline

Il-6 Predicts Cdk4/6 Inhibitor Resistance, Identifying Stat3 As A Target In Hr + /Her2-Negative Metastatic Breast Cancer, Nicole M Kettner, Tuyen N Bui, Juliana Navarro-Yepes, Sanaz Ghotbaldini, Bethanie Quintela, Catherine K Luo, Nghi Lam, Xiayu Rao, Akshara Singareeka Raghavendra, Yan Wang, Nancy Azizian, T Kris Eckols, Moses Makokha Kasembeli, Kurt Evans, Min Yi, Hannah Wingate, Jing Wang, Aysegul A Sahin, Funda Meric-Bernstam, Kelly K Hunt, Senthil Damodaran, David J Tweardy, Debu Tripathy, Khandan Keyomarsi

Faculty, Staff and Student Publications

Resistance to CDK4/6 inhibitors (CDK4/6i) is a major challenge in treating hormone receptor-positive, HER2-negative metastatic breast cancer. This study aimed to identify a biomarker predictive of resistance that could also serve as a therapeutic target. Circulating IL-6 levels in 166 patients significantly increased at progression, making IL-6 a non-invasive biomarker to predict CDK4/6i resistance. Knockdown of IL-6 re-sensitized resistant cells to palbociclib and endocrine therapy, underscoring IL-6's critical role in maintaining resistance. Patient-derived xenograft models from patients who progressed within 3 months versus ≥6 months of palbociclib therapy revealed distinct transcriptomic profiles, with later progressors exhibiting IL-6/STAT3 activation, epithelial-to-mesenchymal transition, …

Perception Of Quality Of Life, Brain Regions, And Cognitive Performance In Hispanic Adults: A Canonical Correlation Approach, Juan C. Lopez-Alvarenga, Jesus D. Melgarejo, Jesus Rivera-Sanchez, Lorena Velazquez-Alvarez, Rosa V. Pirela, John Blangero, Jose E. Cavazos, Michael C. Mahaney, Joseph D. Terwilliger, Gladys E. Maestre

School of Medicine Publications

The quality of life (QoL) perception has been studied in neurological diseases; however, there is limited information linking brain morphological characteristics, QoL, and cognition. Human behavior and perception are associated with specific brain areas that interact through diffuse electrochemical networking. We used magnetic resonance imaging (MRI) to analyze the brain region volume (BRV) correlation with the scores of Rand’s 36-item Short Form Survey (SF-36) and cognitive domains (memory and dementia status). We analyzed data from 420 adult participants in the Maracaibo Aging Study (MAS). Principal component analysis with oblimin axis rotation was used to gather redundant information from brain parcels …

Creation Of Bacteria In Tongue Diagnosis Based On Fractal Methods, S. Pavithra, G. Jayalalitha

Baghdad Science Journal

Bacteria play a vital role in helping with digestion and protecting against harmful infections. However, the Gram-negative bacteria in Tongue will have some disadvantages in the human body. These can be diagnosed by employing the fractal concept. Bacteria's irregular shape and Complex nature can be quantified using fractal dimensions that exhibit self-similarity at different scales. The fractal measurement procedure deliberates the dissimilarity and surface complexity of the tongue-inclusive spot on the tongue. An image of the tongue is analyzed by the HarFa Fractal Method. The Sobel improved Box counting Method is employed to enumerate the outgrowth of Bacteria in Tongue. …

The Effect Of Environmental, Social, And Governance (Esg) Performance And Capital Structure On Firm Value In Manufacturing Companies Listed On The Indonesia Stock Exchange For The 2019–2023 Period, Aliea Yenemia Putri, Citra Sukmadilaga, Adisti Gilang Cempaka

Journal of Accounting Auditing and Business

This study aims to analyze the effect of Environmental, Social, and Governance (ESG) performance and capital structure on firm value in the manufacturing sector listed on the Indonesia Stock Exchange (IDX) for the period 2019–2023. ESG performance is measured using individual and combined scores from LSEG Datastream (Refinitiv). Capital structure is proxied by the Debt-to-Equity Ratio (DER), while firm value is measured using the Tobin’s Q ratio. This research adopts a quantitative approach using panel data regression analysis. The sample consists of 20 manufacturing firms selected through purposive sampling. Control variables include firm size, profitability (ROA), and macroeconomic factors such …

Substitution And Complementarity Between Human And Artificial Intelligence: A Dynamic Capabilities View, Christopher Agyapong Siaw, Waqas Ali

Plymouth Business School

Purpose: This paper draws on the dynamic capabilities (DC) view to develop a conceptual framework that explicates the mechanisms through which human intelligence (HI) and artificial intelligence (AI) substitute and complement each other for organizational knowledge management (KM) while considering the role of ethics. Design/methodology/approach: This is a conceptual paper that draws on DC theory and integrates insights from the burgeoning literature on organizational AI adoption and application to develop a conceptual framework that explains the mechanisms through which HI and AI may substitute and complement each other for organizational KM to develop DC. Findings: The conceptual framework demonstrates that …

Adhd In Youth With Major Depressive Disorder In The Texas Youth Depression And Suicide Research Network (Tx-Ydsrn): Clinical Correlates And Moderators, Blake M Upshaw, Samuel D Spencer, Caitlin M Pinciotti, Vadym Zhyrov, Abu Minhajuddin, Ace A Castillo, Allyssa Abacan, Holli Slater, Rachel A Walker, Joseph C Blader, Sarah L Martin, Jeffrey D Shahidullah, Jair C Soares, Robert Andrew Harper, Madelyn Guerra, Lynnel C Goodman, Wayne K Goodman, Sarah M Wakefield, Madhukar H Trivedi, Eric A Storch

Faculty, Staff and Student Publications

Objective: Depression is a major public health concern with a 19% lifetime prevalence in youth, often precipitating other concerns, including suicidal behavior, poor school performance, and worsened peer relationships. ADHD is also common among youth and frequently presents alongside major depressive disorder (MDD), with this comorbidity associated with increased impairment. More research is needed to elucidate the clinical characteristics of this comorbidity (MDD + ADHD), especially as it relates to youth with MDD and no ADHD (MDD - ADHD). The present study examined the clinical correlates of MDD + ADHD in youth and the presence of an ADHD diagnosis as …

U-Rich Elements Drive Pervasive Cryptic Splicing In 3′ Utr Massively Parallel Reporter Assays, Khoa Dao, Courtney F Jungers, Sergej Djuranovic, Anthony M Mustoe

Faculty, Staff and Students Publications

Untranslated RNA sequences play essential roles in orchestrating gene expression. However, the sequence codes and mechanisms underpinning post-transcriptional regulation remain incompletely understood. Here, we revisit the finding from a prior massively parallel reporter assay (MPRA) that AU-rich elements in 3' untranslated regions (3' UTRs) can drive upregulation or downregulation of mRNA expression depending on 3' UTR context. We unexpectedly discover that this variable regulation arises from widespread cryptic splicing, predominately from an unannotated splice donor in the coding sequence of GFP to diverse acceptor sites in reporter 3' UTRs. Splicing is activated by U-rich sequences, which function as potent position-dependent …

Assessment Of Dnase Activity By Ratiometric Fluorescence Resonance Energy Transfer, Candace L Minchew, Vladimir V Didenko

Faculty, Staff and Students Publications

The present protocol describes a simple and sensitive ratiometric Förster resonance energy transfer (FRET) assay for the detection and quantitative assessment of DNase activity. Ratiometric FRET measurements make use of the ratio of donor and acceptor emission signals. The assay detects single-stranded DNA breaks using a staple-shaped, dual-tagged 38-mer FRET oligoprobe, employed as a real-time DNA cleavage sensor. The main application of the described approach is the quantitative assessment of the effects of reaction conditions, such as pH, temperature, and buffer composition, on DNase activity. Due to its ability to detect even minor and slow DNA cleavage, the assay is …

Re: Comment Letter For The Butte Priority Soils Operable Unit (Bpsou) Draft Final 2025 Residential Metals Abatement Program (Rmap) Valley Sand & Gravel (Builders Firstsource) Borrow Submittal #1 (Dated June 27, 2025), Molly Roby

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Re: Comment Letter For The Butte Priority Soils Operable Unit (Bpsou) Draft Final 2022 Unreclaimed Sites Sampling: Ur-12 Site Evaluation Summary Report (Dated April 8, 2025), Molly Roby

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Re: Comment Letter For Bpsou Uncontrolled Surface Flow Areas Drainage C 30% Design Rawp (Dated June 23, 2025), Molly Roby

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

The Impact Of Teaching Multiple Responses On Resurgence Of Target Behavior And Persistence Of Alternative Responding., Brittany H. Loder-Lafferty, Amanda N. Zangrillo, Alexandra M. Cicero, Cynthia P. Livingston, Jessica P. Tran, Mark Connelly

Manuscripts, Articles, Book Chapters and Other Papers

This study evaluated the effects of teaching multiple alternative responses on the resurgence of a target response and the persistence of an alternative response in an applied setting. Using a between-participants design, we examined how teaching multiple alternative responses impacted resurgence and persistence upon exposure to extinction. Additionally, we investigated the role of preference in response allocation and shifts in participant preference following extinction. Results indicated resurgence across both conditions, with no consistent difference in severity between single and multiple alternative response conditions. However, within-session analyses revealed greater persistence of the alternative response for participants taught multiple alternative responses, suggesting …

Physician And Hospital Performance In Medicare’S Updated Bundled-Payment Model For Joint Replacement, Aidan P. Crowley, Austin S. Kilaru, Qian Erin Huang, Erkuan Wang, Jingsan Zhu, Ayush Arora, Torrey Shirk, Deborah S. Cousins, Kristin A. Linn, Said A. Ibrahim, Joshua M. Liao, Amol S. Navathe

Department of Medicine Faculty Papers

IMPORTANCE: Independent evaluations of Bundled Payments for Care Improvement Advanced (BPCI-A) have focused on hospitals and have not assessed the performance of physicians in participating physician group practices (PGPs). However, PGPs are accountable for a larger proportion of surgical procedures, including for lower-extremity joint replacement, in the BPCI-A model than are hospitals.

OBJECTIVE: To evaluate the association of treatment by BPCI-A-participating physicians and hospitals with health care spending, quality, and utilization for joint replacement procedures compared to nonparticipants.

DESIGN, SETTING, AND PARTICIPANTS: This cohort study used Medicare claims of beneficiaries receiving lower-extremity joint replacement between April 2016 and September 2019 …

The Effect Of Training Exercises Using An Innovative Device On Developing Skill Performance Among Female Foil Fencers, Fatimah Abed Malih, Rimah Mohammed Zuwair, Noor Hatem Al-Haddad, Ardo Okilanda

Modern Sport

The researchers turned to modern technology and artificial intelligence by integrating equipment into the training process. This integration aimed to optimize time and reduce boredom and physical strain in both the instructional and training processes of fencing, through the development of exercises utilizing a device designed to regulate the distance between the feet during advance and retreat movements, with the goal of reaching higher levels of skill performance. This led to the following research question: Does training with the aid of an innovative device positively influence the development of skill performance? The researchers employed the experimental method due to its …

False Confidence And Behavioral-Psychological Balance And Their Relationship With Rational And Irrational Thoughts Among Futsal Players, Sherin Laibi Manati, Aseel Naji Fahd, Sundus Burhan Adham

Modern Sport

This study aimed to examine the levels of false confidence, behavioural psychological balance, and rational and irrational thoughts, as well as to investigate the relationships among these variables in futsal players. To achieve this objective, the researchers developed scales for measuring false confidence and behavioural psychological balance, while the standardized scale for rational and irrational thoughts, developed by Aseel Naji, was adopted for use in the current research. The researchers employed the descriptive method using a correlational approach, as it was deemed the most appropriate for the nature and objectives of the study. The research population consisted of players from …

The Impact Of An Ai-Supported Smart Hiit Program On Cardiovascular Fitness And Physical Performance, Maysaa Redha Ghanem

Modern Sport

In recent years, there has been growing interest in training programs that enhance physical fitness and overall health. Among the most prominent is High-Intensity Interval Training (HIIT), which has demonstrated effectiveness in improving cardiovascular efficiency and boosting physical performance within a relatively short period. With rapid advancements in artificial intelligence (AI), it has become possible to develop smart training solutions that rely on the analysis of biometric and physiological data to deliver personalized programs tailored to individual needs. AI algorithms can analyze users' biological and physical data and generate training regimens based on physiological responses, opening new avenues for improving …

Pengaruh Rasa, Tekstur, Dan Visual Terhadap Willingness To Buy Produk Ayam Geprek Rempah, Diandra Srivania Irwandini, Hasyim Asyari

Jurnal Administrasi Bisnis Terapan

This study explicitly aims to determaine the influence os taset, texture, and visual aspects on consumer Willingness to Buy (WTB) the Ayam Geprek Rempah product. Using a quantitative approach, the research involved 25 respondents who met the criteria, namely having a habit of purchasing food priced between IDR 25,000 and IDR 35,000, ordering food online at least twice a week, having a preference for ayam geprek, and havingtried the Ayam Geprek Rempah product. The data used was secondary data, and the analysis was conducted using the non-parametric statistical test, the Wilcoxon Signed-Ranks Test. The results showed that the taste variable …

Environmental Quality Of Organic Pollutants In Seawater From Tobruk Bay, Libya - A Mediterranean Coastal Study, Mohamed A. Okbah, Maie I. El-Gammal, Mohamed H. Bahnasawi, Abdulali A. M. Balal

Blue Economy

Data on polycyclic aromatic hydrocarbon (PAH) concentrations in the Bay of Tobruk, Libya, remain scarce. The present study establishes a baseline for monitoring PAH levels, identifying their sources, and evaluating associated ecological risks. Seawater samples were collected from nine sites during the summer and winter seasons. The total concentrations of 16 priority PAHs ranged from 62.33 to 454.70 μg/L in summer (mean: 235.23 ± 152.37 μg/L) and from 79.26 to 473.36 μg/L in winter (mean: 253.85 ± 151.49 μg/L), reflecting substantial pollution. Seasonal trends suggest slightly reduced PAH levels in summer, potentially due to changes in industrial output, runoff patterns, …

A Qualitative Study Understanding The Effects Of Eye Movement Desensitization And Reprocessing In Equine Therapy, Linsey Adams, Tara Rava Zolnikov

People and Animals: The International Journal of Research and Practice

This qualitative descriptive study investigates the efficacy of EquiLateral™, an equine-assisted EMDR protocol, in treating PTSD. Amid increasing global cases of stress-related disorders, particularly in the United States, the study explores the experiences of current and former clients engaged in EquiLateral™ therapy with a licensed therapist. The absence of standardized procedures in equine-assisted therapy research has left a gap in understanding specific activities that effectively reduce PTSD symptoms. Through semi-structured interviews, the study captures participants’ experiences and perceptions, revealing transformative impacts of EquiLateral™ therapy on managing PTSD. Nine thematic findings emerged: life-changing, present moment, calmness, safety and trust, manageability, changed …