Digital Commons Network^™

Intestinal Stromal Cells Play A Critical Role In Protection Mediated By Male Microbiota-Derived Metabolites And Androgens Against Disease In Lupus-Prone Mice., Jing Ma

Electronic Theses and Dissertations

Systemic lupus erythematosus (SLE) is a complex autoimmune disease involving broad immune dysregulation. Despite decades of research, most lupus treatments still have limited effectiveness and can cause serious side effects. Both genetic and environmental factors contribute to lupus susceptibility, and a better understanding of how environmental factors influence disease could guide future therapeutic strategies. SLE shows a strong female predominance. Growing evidence implicates the gut microbiota and sex hormones as key environmental contributors to some autoimmune diseases, including lupus. The gut microbiota can influence host immune function, and interestingly, recent studies have revealed sex-bias in microbiota composition and function. Moreover, …

Synthetic And Pharmacological Diversity Of Nitrogen-Containing Heterocycles., Shramana Ghosh

Electronic Theses and Dissertations

Nitrogen-containing heterocycles are a foundational class of compounds in organic chemistry, playing critical roles in pharmaceuticals, agrochemicals, and natural products due to their structural diversity and biological relevance. Among them, isoindolinones are notable for their wide range of pharmacological activities. Structurally, isoindolinones possess a benzylic methylene group adjacent to the nitrogen atom, which allows for selective oxidative transformations to yield phthalimide derivatives, well-known intermediates in synthetic, pharmaceutical, and materials chemistry. Although phthalimide is traditionally employed as a protecting group for amines via the Gabriel synthesis, isoindolinone offers a valuable alternative. Through a modified Gabriel-like approach, isoindolinones can serve as more …

Mental Health Service Utilization Among Arab/Middle Eastern In The Us: Structural Disparities, Digital Access, And Stigma-Related Barriers., Fatima M. Aldarweesh

Electronic Theses and Dissertations

Arab Middle Eastern (AME) United States (US) college-attending students are more susceptible to disproportionate mental health problems and underutilization of mental healthcare services due to cultural, structural, and psychosocial barriers. The study examines mental health service utilization and mental health outcomes among AME, particularly focusing on the impact of structural, cultural, and psychosocial determinants grounded in Andersen and Aday’s Health Services research model and Corrigan’s stigma framework. The three interconnected aims use secondary nationally representative data from the Healthy Minds Study (HMS) 2019-2024. The study was analyzed using logistic regression and generalized structural equation modeling across three aims to identify …

Predictor-Informed Bayesian Nonparametric Clustering., Md Yasin Ali Parh

Electronic Theses and Dissertations

In this dissertation, we performed clustering of observations such that the cluster membership is influenced by a set of predictors. To that end, we employ the Bayesian nonparametric Common Atom Model (CAM), which is a nested clustering algorithm that utilizes a (fixed) group membership for each observation to encourage more similar clustering of members of the same group. CAM operates by assuming each group has its own vector of cluster probabilities, which are themselves clustered to allow similar clustering for some groups. We extend this approach by treating the group membership as an unknown latent variable determined as a flexible …

The Influence Of Psychological, Biological, And Social Determinants On Disordered Eating Behaviors Among U.S. Young Adults: Evidence From Nhanes 2015-2018., Samantha Kaye Gerbine

Electronic Theses and Dissertations

Disordered eating behaviors (DEBs) are influenced by biological, social, and psychological factors, yet research often narrowly focuses on White, college-aged women. This study assessed the predictors and prevalence of DEBs in a nationally representative sample of U.S. young adults using data from the 2015–2018 National Health and Nutrition Examination Survey (NHANES). Survey weights were applied to generate national estimates. Descriptive statistics characterized the sample, and logistic regressions tested biological, social, and psychological predictors of DEBs. A composite risk score was developed using variables retained in the final model. The unweighted sample (n = 1,062) represented 64 million U.S. young adults. …

Crossed Stitches: Tension And Transformation In Nineteenth-Century Embroidery Samplers., Hayley Salo

Electronic Theses and Dissertations

Originally designed as practice pieces, embroidery samplers have long been studied as domestic objects and part of sewing history. Interpretations of the material and textual significance of individual samplers is less common. However, recent scholarly attention has turned to using sewing practices and objects as a means for understanding individual stitchers and their contributions to public discourse. As such, a focused study of the material and textual content of embroidery samplers furthers our understanding of the genre on its own and as a wider textile practices. Crossed Stitches is interested in the production, portability, circulation, and reception of embroidery samplers …

"That’S Not A Meal, Bestie”: Humor, Identity, & Feminized Consumption In “Girl Dinner”., Claire Tudor

Electronic Theses and Dissertations

This thesis examines the viral “Girl Dinner” trend as a case study in how gendered consumption, digital identity, and feminist humor intersect in digital spaces. Using “Girl Dinner” as a rhetorical artifact, this thesis explores how women use gendered trends to navigate visibility, labor, and autonomy in online spaces. Through thematic analysis of TikTok content, media coverage, and branded adaptations, the research traces the evolution of the trend from a lighthearted joke to a site of cultural negotiation. This study reveals that while “Girl Dinner” may appear empowering and relatable on the surface, it often reinforces traditional gender expectations under …

Rhetorical Analysis Of Kristen Bell's Articulation Of Imperfect Motherhood On Armchair Expert., Sarah J. Neff

Electronic Theses and Dissertations

This thesis explores how Kristen Bell’s articulation of imperfect motherhood, as heard on the popular podcast Armchair Expert, contributes to broader social discourses surrounding motherhood, empowering some mothers while inadvertently constraining others. Using rhetorical analysis grounded in Goffman’s dramaturgical approach, facework theory, and McGee’s theory of fragments, this study explores Bell’s discourse and performance of motherhood within the podcast medium. The podcasting medium provides a rich source for rhetorical analysis due to the long form interview content, and emotionally nuanced content, leading to a stronger connection with the audience. This is evident with the new headlines that follow Bell’s appearance …

Role Of Cardiac Ketone Body Metabolism In Myocardial Perfusion And Exercise Performance., Kara R. Gouwens

Electronic Theses and Dissertations

Cardiorespiratory fitness, a crucial determinant of overall health and a strong predictor of all-cause mortality, is largely dependent on the capacity of the cardiovascular system to deliver oxygen and nutrients. The heart, as the central pump, requires a continuous and adaptable oxygen supply, particularly during increased workload such as occurs with exercise. Impaired myocardial blood flow (MBF) in response to increased demand can lead to ischemia, limiting exercise capacity and potentially causing severe cardiac events. Interestingly, changes in myocardial metabolism and cardiac work correlate with changes in MBF. Therefore, understanding the regulation of MBF, especially the link between local cardiac …

Bleeding Out From The Redlining: An Autoethnographic Study Of Racial Equity Policy Enactment In A Large, Urban School District., Anderson Aven Cook

Electronic Theses and Dissertations

This autoethnographic study investigates the enactment and impact of racial equity policies within Jefferson County Public Schools (JCPS), a large urban school district in Louisville, Kentucky. The research is motivated by the ongoing challenges of achieving true educational equity for Black and Brown students, a struggle rooted in historical injustices such as redlining. Despite over seven years of policy implementation aimed at promoting racial equity, academic and behavioral disparities between Black and Brown students and their White counterparts have shown little improvement. Utilizing a qualitative methodology, this study employs autoethnography to intertwine personal narrative with scholarly analysis, exploring the lived …

Incarcerated Women: Gendered Rhetoric From The Outside And Reality Inside Prison Walls., Taylor Riley Geiser

Electronic Theses and Dissertations

This dissertation examines how formerly incarcerated women navigate and resist gendered media portrayals through digital platforms, focusing on the “mad” and “bad” woman tropes that shape public perceptions. Drawing on feminist rhetorical theory—particularly Royster and Kirsch’s methodological practices and Ratcliffe’s concept of rhetorical listening—this study combines Critical Discourse Analysis (CDA) of mainstream headlines with Multimodal Discourse Analysis (MDA) of TikTok content. CDA of media coverage surrounding Lori Vallow Daybell, Casey Anthony, and Andrea Yates reveals how language, imagery, and cultural logics sustain harmful binaries that portray women who commit crimes either as depraved or as excused by madness, obscuring the …

Genes That Matter: Survival Modeling In Tcga-Brca With Treatment Interactions., David Pratt

Electronic Theses and Dissertations

High-dimensional genomic data offer both promise and challenges for identifying clinically relevant biomarkers. This study developed a parallelized survival modeling pipeline to identify genes associated with overall survival in breast cancer, with a focus on gene-by-treatment interactions and patient heterogeneity. RNA-Seq data from female patients in the TCGA-BRCA cohort were analyzed. Univariate Cox proportional hazards models were used to screen genes, adjusting for age, race/ethnicity, treatment status, and cancer stage. A LASSO-penalized Cox regression was fit across 2000 random seeds to assess feature stability. Genes were filtered by expression level, statistical significance, and hazard ratios (effect sizes) in either direction, …

Engaging In Movement At Work: Exploring Engagement And Physical Activity., Spencer A. Cavan

Electronic Theses and Dissertations

High levels of employee engagement provide organizations competitive advantages such as increased customer satisfaction, profits, and employee productivity. Despite potential benefits, the number of engaged employees is declining and organizations need to find innovative ways to enhance engagement. Emerging evidence suggests workplace physical activity may generate organizational benefits extending beyond health improvement. Therefore, the purpose of this study was to investigate perceptions of engagement among employees participating in a physical activity intervention at work. A qualitative design, guided by phenomenology, examined perceptions of workplace physical activity and perceived levels of engagement, as well as constraints related to involvement among university …

Why Are Parents Choosing Forest Preschool? A Look Into Parent Choice And Outcome Expectations In A Forest Preschool Setting., Victoria M. Jones

Electronic Theses and Dissertations

As interest in alternative early childhood education settings continues to grow, Forest Preschools—programs emphasizing immersive outdoor, nature-based learning—have gained increasing attention from parents across the United States. This qualitative research study explores the underlying motivations and decision-making processes that lead families to choose Forest Preschool settings. Guided by Kurt Lewin’s Field Theory, which examines behavior as a function of person and environment, the study investigates the dynamic interplay of personal beliefs, social influences, and contextual factors that shape parental choice. Specifically, this study addresses four key research questions: (1) How do families who choose Forest Preschools gain information about preschool …

Owl Integrations Soil Monitor, Derek Chau, Armaan Kahlon

Electrical Engineering

This paper examines the design process and results concerning the OWL Integrations soil monitor. Disaster relief relies heavily on digital communications, especially in environments where conventional methods (e.g. Wi-Fi, cellular, fiber optics) are unusable. To help emergency services assess disaster-stricken areas, a soil monitoring system was developed using LilyGo T-Beams (ESP32), programmed with specialized firmware known as the ClusterDuck Protocol to collect data pertaining to moisture and temperature. The project is sponsored by OWL Integrations, with help from the Cal Poly Electrical Engineering (EE) Department. Results show positive prospects, with the product able to make 4 km transmissions, operate for …

Improving Antipsychotic Compliance By Addressing Client Experience Of Metabolic Syndrome, Lurinda N. Paulsen

Doctor of Nursing Practice

Abstract

Purpose: This project was undertaken to increase medication adherence in clients diagnosed with mental illnesses that necessitate the use of antipsychotic (second generation, atypical or first generation, typical) medications.

Background: Medication compliance in the treatment of schizophrenia, schizoaffective disorder, and bipolar disorder is essential to ensure consistent medication levels and symptom stabilization. There are many reasons clients stop taking their medications, and symptoms of metabolic syndrome are often a cause for self-discontinuation. Metabolic syndrome is a cluster of symptoms including obesity, hypertension, hyperglycemia, hypoalphalipoproteinemia, and/or hypertriglyceridemia, which increases risk for cardiovascular disease and diabetes.

Methods: This project was completed …

Exploring The Effect Of Social Determinants Of Health (Sdoh) Factors On The Time To Kidney Transplant Evaluation Completion For African American End Stage Renal Disease (Esrd) Patients, Kesha Levesque

MUSC Theses and Dissertations

Purpose – The purpose of this dissertation is to investigate the relationship between demographics and Social Determinants of Health (SDOH) variables on diagnostic testing time completion in patients being evaluated for kidney transplant waitlisting.

Aims - Compared to White Americans, African Americans who are eligible to receive a kidney transplant are less likely to complete the required testing in order to be placed on the kidney transplant waiting list which puts African Americans at risk for morbidity and mortality due to prolonged exposure to dialysis. The COVID-19 pandemic was directly associated with a decrease in the number of patients placed …

The Effects Of Hunger, Starvation, And Famine On Certain Eating Habits: A Cross-Cultural Study, Robert Dirks

Faculty Publications – Sociology and Anthropology

This paper examines the impact of starvation and famine on certain eating habits. These include commensal relations within households, dispositions towards eating with strangers and modes of appetite expression. It tests the proposition that much of the variation seen in these aspects of eating behavior worldwide can be explained by societal experiences with hunger. The study analyzes data from 124 societies and finds significant associations between episodes of food insufficiency and non-inclusive, uncongenial eating practices. This research contributes to the understanding of how food supply and nutritional circumstances shape cultural arrangements and offers insights into the broader implications of food …

Family And School Engagement: Educators’ Behaviors And Practices That Effectively Engage Families To Benefit Historically Underserved K-8 Students, Germaine Smith

All-Inclusive List of Electronic Theses and Dissertations

Decades of research affirm that family-school partnerships are essential to students’ academic and social-emotional success. Researchers have uncovered barriers, identified solutions, and developed frameworks and models to assist schools in improving their family partnerships. Despite legislation to foster family engagement, schools’ development of parent engagement policies, adoption of proven engagement programs, and investment in training to improve family connections, historically underserved students continue to fall through the cracks. This study aims to identify and quantify the behaviors and practices most effective in engaging families of historically underserved elementary and middle school students. Grounded in Maslow’s Hierarchy of Needs and Bronfenbrenner’s …

Is There Something Schools Can Learn From Black Churches?, Samantha Marie Smith

All-Inclusive List of Electronic Theses and Dissertations

The purpose of this qualitative study was to investigate and gain meaning of the experiences of families with school aged children and why they trust and value Black churches versus the school education system and if there is anything that schools can learn from roles that Black churches play in families’ lives. The research was guided by the following questions: (1) How do Black churches build relationships with families, consistently and effectively engage children, and teach children? (2) How do schools build relationships with families, consistently and effectively engage children, and teach children? (3) Is there anything that schools can …

An Examination Of Teacher Perceptions Of Middle School Behavior Management And Intervention, Raechel Brianne Roberts

All-Inclusive List of Electronic Theses and Dissertations

Research indicates that behavior management and intervention is a complex experience in school settings. Middle school students, in particular, must contend with physical, social, and educational changes and responsibilities, which may impact their behavioral responses and relationships with their teachers. The literature suggests that teachers often report that there are limitations to support for behavioral management in regards to pre-service training, access to research-based practices, and barriers to successful intervention implementation. The purpose of this qualitative study was to privilege the lived experiences of middle school teachers and their needs for working with students with challenging behaviors. The study included …

Shielding From Culpability: The Responsibility System In Eu’S Asylum And Migration Policy, Bjarne Bachmann

UC Law SF International Law Review

No abstract provided.

Bruce Norton V. Joseph Adams

2025 Decisions

USDC for the Middle District of Pennsylvania

Evaluating The Effectiveness Of Individual Cleaning Steps Of A Cip Protocol In Membrane Biofilm Removal Under Dynamic Conditions, Diwaker Singh, Sanjeev Anand

Dairy Science and Food Science Faculty Publications: 2022 to Present

This study evaluated the effectiveness of individual clean-in-place (CIP) steps in removing biofilms from reverse osmosis (RO) membranes under dynamic flow conditions using the Centers for Disease Control (CDC) biofilm reactor. Biofilms were developed in the laboratory under continuous flow, using mixed-species bacterial isolates obtained from 10-month-old RO membrane biofilms from a commercial facility. Individual CIP chemicals, representative of those used in commercial protocols, were tested against 24 h-old biofilms. Additionally, a complete six-step sequential CIP process was conducted under dynamic conditions, consisting of treatments with alkali, surfactant, acid, enzyme, a secondary surfactant, and sanitizer. All experiments were performed in …

Comparative Impacts Of Irradiation On Antioxidant Compounds Of Scalded And Non-Scalded Skin Of Granny Smith Apples, Angela Banda

Food Science (MS) Theses

Post-harvest Superficial scald affects the quality of Granny Smith Apples. Oxidative stress develops superficial scald with antioxidant systems mitigating the extent of this damage. This study evaluated the effects of gamma, X-ray, and electron beam irradiation on antioxidants – ascorbic acid, total phenolics, α-tocopherol, carotenoids, chlorophyll, and campesterol – in scalded and non-scalded apple peel tissue. Apples were treated with 0.2-0.77 kGy and stored at 0-1 °C. Irradiation at the applied doses increased scald incidence, suggesting that disruption of antioxidant systems promoted reactive oxygen species accumulation and membrane damage. While certain antioxidants appeared to be upregulated as a stress response, …

Equity Fund Monthly Report, August 2025, Archway Investment Fund

Archway Investment Fund

No abstract provided.

Navigating Childhood Asthma Care In Kenya: Barriers Identified By Children And Their Caregivers, Joan Ahimbisibwe, Roselyter Riang’A, Angela Migowa, Samuel Otido

Paediatrics and Child Health, East Africa

Background: Asthma is one of the most common chronic conditions in children, with significant morbidity and mortality, especially in Africa. Achieving adequate asthma control in children remains challenging because of gaps between standard recommended management strategies and actual treatment practices. This study explored barriers to asthma management as perceived by children and their caregivers in a private tertiary care setting in Kenya.

Methods: An exploratory phenomenological qualitative study was conducted at Aga Khan University Hospital (AKUH), Nairobi. Children aged 6–18 years with a confirmed diagnosis of asthma and their caregivers were recruited. The participants had been receiving treatment for at …

Dissecting The Heterogeneous Effects Of Opioid Prescribing Limit Laws On Pediatric Mortality: A Multidimensional And Negative Binomial Modeling Approach, Francine R. Vega

Dissertations and Theses (Open Access)

Opioid prescribing for children and adolescents continues to be a significant health crisis in the United States. Early naïve exposure to opioid prescriptions has been linked to later misuse, opioid use disorder, and death. In response to the crisis, many states have implemented opioid prescribing limit laws (OPLLs) aimed at reducing exposure to opioids. These laws vary widely in their approach, including differences in dosage restrictions, prescription duration limits, informed consent requirements, educational provisions, and whether they offer explicit protections specifically for minors. Despite their widespread adoption, there is limited understanding of how heterogeneity in legal regulations affects outcomes for …

Rethinking Health Systems Responsiveness In Low–And Middle-Income Countries, Meesha Iqbal

Dissertations and Theses (Open Access)

Health systems responsiveness (HSR) refers to a health system’s ability to meet legitimate non-health expectations of the population. Traditionally, HSR has been conceptualized across eight domains: respect for dignity, autonomy, confidentiality, prompt attention to health needs, availability of basic amenities, choice of provider, access to social support networks, and clarity of communication. However, as the expectations of populations in high-income countries (HICs) and low- and middle-income countries (L&MICs) differ significantly due to diverse social and cultural contexts, the conceptualization of HSR also varies. We conducted a systematic review of literature to adapt and contextualize the HSR framework for L&MICs based …

Institutional Racism In The Discretionary Legalization Of Marijuana, Gary D. Brinker Ph.D.

Sociology Faculty Publications

Our research showed that states with the strongest evidence of discretionary policing were also the states that tended to keep marijuana illegal, facilitating a discriminatory form of drug enforcement that makes ethnic minorities more likely than whites to live where marijuana is illegal.