Digital Commons Network^™

Specificity Of Interaction Of Antimicrobial Peptide With Cell Membrane, Srishhti Kumar Jha

Pharmaceutical Sciences (MS) Theses

Antimicrobial resistance (AMR) is an increasing global health threat due to its rising incidence worldwide. Resistant microbial infections have become difficult to treat and pose serious risks to patients. In 2019, AMR was responsible for approximately 1.27 million deaths globally, with numbers continuing to rise. The World Health Organization (WHO) has highlighted the urgent need for new antibiotics with novel mechanisms of action and low toxicity to combat this issue. Antimicrobial peptides (AMPs) represent a promising solution. These peptides exhibit broad-spectrum antimicrobial activity and rapid killing kinetics, reducing the likelihood of resistance development. AMPs primarily target bacterial cell membranes. Their …

Utahns’ Understanding & Support Of Environmental Equity & Justice, Dallin Johnson, Jordan Rowley, Stacia Ryder, Jennifer E. Givens, Avery C. Edenfield, Harley Thomas

Utah People and Environment Poll (UPEP)

Utah faces its fair share of environmental problems. Top concerns among residents are issues of drought, air quality, and the drying of the Great Salt Lake (1). However, research suggests that the impacts of environmental issues like disasters, pollution, resource overuse and climate change are not shared equally across society (2). This is a challenge for environmental justice, which maintains the need for fair treatment and outcomes for all people, regardless of race, ethnicity, and class, with respect to the enforcement of environmental laws, regulations, and policies (3). Put more simply, everyone is entitled to a clean and healthy environment …

Incidence Of Peripheral Intravenous Cannula Complications And Associated Factors Among Paediatric Patients At A Tertiary-Care Referral Hospital, Vanessa Minsari Ogega

Master of Medicine in Paediatrics and Child Health

Introduction: Peripheral intravenous catheters (PIVCs) are widely used in clinical practice and are a major source of procedure-related pain in children. Their use is associated with complications including occlusion, dislodgement, infiltration, extravasation, phlebitis, and, rarely, bloodstream infections.

Objectives: To determine the incidence and risk factors associated with PIVC complications among paediatric patients aged 1 day to 18 years at Aga Khan University Hospital, Nairobi. The study also assessed the average survival time of PIVCs.

Methods: A prospective cohort study was conducted on 320 PIVCs among 192 children admitted between August and October 2024. Data collected included patient demographics, clinical characteristics, …

Mosquitoes: The 5 C’S Of Developing Disease- Commensals Changing To Consequential Pathogens, Alan L. Gillen, Caleb Mast, Robert Braden Somerville

Faculty Publications and Presentations

Hotter, longer summers and changing weather patterns in the United States are bringing more than just sweat and discomfort. In May 2025, a summer heat wave of 107⁰F hit Austin, Texas, and in humid Houston and San Antonio, Texas, temperatures felt over 100⁰ for several days. Normally, these temperatures don’t come until July and August. With temperatures reaching these marks early and heavy rains coming, mosquito activity and ranges expand. Many state and federal health officials report a rise in mosquito-borne illnesses across the US and globe in the last five years.

Mae Enewsbrief Apr- June 2025, Department Of Mechanical And Aerospace Engineering, Michigan Technological University

Department of Mechanical and Aerospace Engineering eNewsBrief

No abstract provided.

Kenyan Dietitians’ Knowledge Of Ketogenic Dietary Therapies For Drug-Resistant Epilepsy, Pauline Samia, Violet Naanyu, Perry Ndila, Helen Cross, Richard Idro, Paul Boon, Jo Wilmshurst, Stanley Luchters

Paediatrics and Child Health, East Africa

Background: Ketogenic dietary therapy (KDT) has been proven to be efficacious for people with drug-resistant epilepsy. However, it is rarely utilized in low-resource settings. Due to the complexity of implementation, dietitians play a crucial role in managing KDT.

Methods: We conducted a cross-sectional survey of 253 out of the 1,000 registered dietitians. We assessed their knowledge of and interest in further training in KDT.

Results: Most participants were female (78%), with a median age of 33 years (IQR=28–38). A total of 171 (67.6%) reported knowledge of KDT. However, only 13 respondents (7.6%) answered all five knowledge-specific questions correctly. A …

Predicting Miner Localization In Underground Mine Emergencies Using A Hybrid Cnn-Lstm Model With Data From Delay-Tolerant Network Databases, Patrick Nonguin, Samuel Frimpong, Sanjay Madria

Mining Engineering Faculty Research & Creative Works

Underground mining environments are highly hazardous, often prone to gas explosions, cave-ins, and fires that may trap miners during emergencies. The accurate, real-time localization of miners is vital for effective self-escape and rescue operations. Although the Mine Improvement and New Emergency Response (MINER) Act of 2006 mandates communication and tracking systems, most current solutions rely on low-power devices and line-of-sight methods that are ineffective in GPS-denied, dynamic subsurface conditions. Delay-Tolerant Networking (DTN) has emerged as a promising alternative by supporting message relay through intermittent links. In this work, we propose a deep learning framework that combines Convolutional Neural Networks (CNNs) …

Co-Creating Play:Utilizing Comics To Potentialize Participatory Self-Determination In Marginilized Young Adults, Marlin Mcknight

Graduate Theses and Dissertations

Storytelling has long served as a vital mechanism for preserving cultural heritage, transmitting values, and fostering intergenerational connection (Moeshlin, 2024). Despite this significance, graphic narratives such as comics and graphic novels have been historically marginalized—dismissed as trivial “children’s media” or reduced to entertainment rather than recognized as culturally resonant tools (McCloud, 1993). This marginalization intensified as comics evolved to depict adult themes and, at times, harmful stereotypes, triggering social backlash that stigmatized their utility for younger audiences (Segran, 2020). Consequently, scholarly exploration of comics’ therapeutic potential has stagnated, hindered by the medium’s tumultuous history. This study bridges this gap by …

Engineered Interfaces For Enhanced Transient Liquid Phase Bonding In Electronics Assembly, John Russell Harris

Graduate Theses and Dissertations

Growing applications in transportation make power density a key optimization target in the power electronics industry. More power in a shrinking environment leads to high heat flux and junction temperatures that damage silicon-based switching devices. Temperatures approaching 175℃ can result in false triggering of the device’s activated state, resulting in short circuits. Developing wide bandgap semi-conductors, such as gallium nitride and silicon carbide, are less susceptible to this complication as the energy from elevated temperature is a smaller fraction of what would be required to trigger the device. These devices are projected to function reliably in environments of up to …

M Book, 2025-2026, University Of Mississippi

M Book

No abstract provided.

Interview With Former Chairman Of Cardiology E. Berry Hey, Jr. Md, Caitlin Moss

Historic Narratives

No abstract provided.

Tremblings, August 2025, Western Aspen Alliance

Tremblings

Small-stand Challenges in the Northern Rockies

Brytten Steed, PhD, USFS Forest Entomologist (retired) Forest Health Protection - Missoula Field Office

Aspen in the Northern Rocky Mountains exist more often as small, scattered patches or “stringers” than the iconic landscapes of aspen found elsewhere. Like early-season fireflies, they dot the landscape where moisture is present, ringing potholes, lining streams, or clinging to topographies rich in subsurface moisture. Their rarity belies their importance to wildlife, livestock, fire movement, and humans. Aspen are preferred browse for large herbivores, a hotspot for birds, and home to a diversity of plants. People, too, gravitate …

The Social Dimensions Of Aquaculture: Food Sovereignty And Indigenous Rights In Ketchikan, Alaska, Morgan J. Davis

Capstone Collection

This research project asks how the growing commercial aquaculture industry in Ketchikan, Alaska, functions to alleviate or exacerbate local food insecurity; reinforce or undermine food sovereignty among Indigenous communities, and enhance or restrict community participation in the control of marine resources. Global initiatives have responded to food insecurity through agricultural inputs and technology to create higher yields; however, conventional agricultural production has contributed to and is increasingly vulnerable to climate change. To address higher demands for food, government agencies and development experts have looked towards Blue Growth and aquaculture as a solution for food insecurity and environmental concerns. While aquaculture …

Examining Parent Accommodation Of Anxiety And Irritability In Preschool-Aged Children., Anna Olczyk

Electronic Theses and Dissertations

Anxiety and irritability are common developmentally normative emotions in early childhood, yet are also related to risk for psychopathology in childhood, adolescence, and adulthood. Parenting behaviors, including parent accommodation, may influence this risk. Parent accommodation is the parent modification of child/family routines and/or avoidance of activities to reduce child distress and has been documented widely in the anxiety literature. Although some research has examined parent accommodation of anxiety in preschool-aged children, most research has investigated accommodation of anxiety in clinical samples of school-aged children. Further, despite high rates of co-occurrence between child anxiety and irritability, research on parent accommodation of …

Peer Functioning And Risk For Co-Occurring Adhd And Anxiety Symptoms In School-Aged Children: A Cross-Sectional And Longitudinal Analysis., Helena F. Alacha

Electronic Theses and Dissertations

Background. Youth with Attention-deficit/hyperactivity disorder (ADHD) often have higher rates of anxiety in comparison to their peers without ADHD. Children with co-occurring ADHD and anxiety exhibit a unique clinical presentation that poses challenges to both assessment and treatment. Consequently, children with comorbid ADHD and anxiety experience increased impairment, and often have poorer long-term outcomes than children with either ADHD or anxiety alone. Preliminary evidence suggests that different psychosocial phenomena commonly experienced by children with ADHD—such as peer functioning—may increase susceptibility to anxiety. Considering that children with ADHD encounter a range of peer difficulties, the present study proposed and evaluated different …

Assessing Medical Decision-Making Capacity: The Importance Of Patient Values., Emilee M. Ertle

Electronic Theses and Dissertations

A medical decision-making capacity (MDC) assessment is the assessment of an individual to determine whether they can make their own medical decisions or if a proxy decision maker must make care decisions on their behalf. These assessments are necessary when individuals experience cognitive impairments which limit their ability to think through complex medical decisions. Best practice for MDC assessments is a growing area of research, with no standard approach to guide assessment planning. The current study builds upon the field’s knowledge of capacity assessments by investigating 1) what methods and measures clinicians utilize in capacity assessments, 2) what factors influence …

Dementia Caregiving Styles: Characterizing Dementia Caregivers Via A Novel Framework., Darby M. Simon

Electronic Theses and Dissertations

As dementia rates increase, effective family caregivers are crucial to meeting the increasing demand for dementia care. However, dementia caregiving is a demanding experience, and caregivers have varying strategies for providing care, leading to positive and negative outcomes and appraisals of their caregiving experience. Limited research explores this relationship, and extant work is qualitative with no clinical measure. This study adapted a pre-existing framework/measure from a different caregiver population (parents) to explore a) if the same framework applied to both caregiving populations and b) the associations between the styles and psychological well-being and other caregiving variables. Exploratory Factor Analysis tested …

Effects Of Perfluorooctane Sulfonate In A Mouse Model Of Alcohol-Associated Liver Disease., Paxton Michelle Brizendine/Ames

Electronic Theses and Dissertations

Perfluorooctane sulfonate (PFOS), a pervasive environmental pollutant, has been increasingly associated with the development of metabolic dysfunction-associated steatotic liver disease (MASLD); nonetheless, its connections with alcohol-associated liver disease (ALD) have not been well studied. This study investigates the hypothesis that PFOS exposure alters hepatic metabolism, thereby leading to alterations in ALD severity. Male C57BL/6J mice were fed isocaloric control or 5% ethanol (EtOH) diet for 15 days. From day 6 of feeding, mice were concurrently gavaged with 1 mg/kg PFOS or 2% Tween-80 vehicle for 10 days, followed by a 5 g/kg EtOH binge dose. PFOS and ethanol co-exposure significantly …

Cbl Regulation Of C-Met Signaling In Corneal Epithelial Cells., Kate Elise Tarvestad Laise

Electronic Theses and Dissertations

The cornea is the most anterior portion of the eye and permits light passage through to retina, allowing formation of a clear image as long as it remains healthy. If the cornea sustains damage, it creates and entrance for foreign body invasion, infection, and ultimately blindness in the immunocompromised eye. Healing the corneal tissue is critical for vision restoration and pain alleviation, as it is the most densely innervated tissue in the body. Growth factors and their cognate receptors are currently under investigation as tools to restore proper corneal physiology. We hypothesize that manipulating the hepatocyte growth factor (HGF) /c-Met …

Metabolic Regulation Of Cardiac Fibroblast Phenotype And Function., Collin Kleis Wells

Electronic Theses and Dissertations

Cardiac fibroblasts are central effectors of cardiac repair after myocardial infarction (MI). In response to signaling cues, they differentiate to a range of phenotypes with robust capacities to synthesize and secrete extracellular matrix (ECM) and signaling molecules. Although activated fibroblast phenotypes are associated with pronounced changes in metabolism, it remains unclear how the metabolic network upholds the effector functions of fibroblasts in the post-infarcted heart. Here, we identified that critical enzymes in the phosphoenolpyruvate (PEP) cycle, i.e. pyruvate kinase muscle-2 (PKM2) and phosphoenolpyruvate carboxykinase-2 (PCK2), are elevated in the heart after MI and examined their role in regulating post-MI remodeling …

Hybrid Geographies And Nature In The City: A Tale Of Two Greenspaces In Louisville, Ky., Rebecca Dixon

Electronic Theses and Dissertations

Many conservation initiatives position nature and the urban as opposing constructions, which means the possibilities where cities can work with nature are often overlooked. This study uses the lens of relational geographies to examine nature in the city by comparing two greenspaces in the Beargrass Creek watershed in Louisville, Kentucky: Waterfront Botanical Gardens and the Louisville Nature Center. The two organizations are compared by using a combination of content analysis, discourse analysis, and GIS flood analysis methods to determine how their geographical location and history affect the ways in which the dynamic between nature and culture is reproduced. Results show …

Estimation Methods For Bayesian Exponential Random Graph Models Under The Horseshoe Prior., Pamela Linares

Electronic Theses and Dissertations

Networks are powerful tools for modeling the complexity of social interactions, biological systems, and information spread. A leading statistical frameworks for analyzing network data are Exponential Random Graph Models (ERGMs), which provide a principled approach to capturing structural dependencies. However, ERGMs remain challenging to estimate, especially in sparse or high-dimensional settings where models suffer from degeneracy and unstable parameter inference. This paper proposes a penalized Bayesian approach to ERGMs that utilizes the horseshoe prior, a sparsity-inducing global-local shrinkage prior. This prior offers robust regularization while preserving important signals, improving estimation by shrinking irrelevant parameters and reducing the impact of extreme …

Evometric: An Interactive Framework For Scalable Visual Analytics Of Time Series Data With Dynamic Changes., Jiahang Huang

Electronic Theses and Dissertations

In today's data-intensive landscape, rapid advances in digital sensing and recording technologies have enabled the acquisition of high-resolution multimodal time series data, capturing intricate real-world dynamics across various domains such as healthcare, behavioral science, and environmental monitoring. However, the complexity and scale of these datasets present significant analytical challenges, particularly in understanding dynamic changes at both individual and cohort levels. This dissertation introduces EvoMetric, a novel visual analytics framework designed to support scalable exploration and analysis of large-scale multimodal time series data with dynamic changes. EvoMetric seamlessly integrates individual-level temporal dynamics with population-level comparative insights, enabling users to visually …

A Deep Learning Approach For Semantic Segmentation And Its Application On Ctc., Samir Farag Harb

Electronic Theses and Dissertations

This dissertation explores the modeling and analysis of medical images, focusing on the intricate task of colon segmentation and subsequent 3D reconstruction, which are critical steps in Computed Tomography Colonography (CTC) systems. The primary objective of this research is to develop precise segmentation approaches to enhance the accuracy of colon identification and reconstruction from abdominal CT scans. Three distinct segmentation approaches are proposed and evaluated: a Markov Random Field (MRF)-based approach, a convolutional neural network (CNN)-based deep learning (DL) approach, and a sequential episodic training with dual contrastive learning Approach (G-SET-DCL) that has a flavor of few-shot learning (FSL). To …

Ecosystem Services Of Urban Green Spaces In Louisville, Ky., Julia Kachanova

Electronic Theses and Dissertations

Accelerating urbanization poses critical challenges to urban green spaces (UGS), vital for ecological balance and human health. Rapid development often results in fragmented habitats, biodiversity loss, and diminished ecosystem service delivery. There is an urgent need to explore and evaluate novel strategies capable of enhancing urban resilience, such as implementing urban orchards, and managing existing parks and gardens in sustainable ways. This dissertation explores how different forms of urban green spaces (UGS) contribute to the provision and maintenance of critical ecosystem services that support human well-being and urban biodiversity. By analyzing UGS impact on ecosystem service provisioning and long-term sustainability, …

Immunopathogenic Crosstalk Between Cancer And The Kidney: A Central Role For Macrophages As Potential Mediators., Dana Hammouri

Electronic Theses and Dissertations

Cisplatin remains a mainstay in the treatment of solid tumors, yet its therapeutic efficacy is frequently compromised by dose-limiting nephrotoxicity. Approximately 30% of patients receiving cisplatin develop acute kidney injury (AKI), which increases the risk of chronic kidney disease (CKD), a leading cause of morbidity and mortality. Despite extensive preclinical efforts, no FDA-approved therapy currently exists to prevent or treat cisplatin-induced nephrotoxicity (CIN). This in part is due to the reliance of preclinical studies on non-cancer animal models that fail to capture the complex physiological alterations associated with malignancy. To address this limitation, we developed a clinically relevant model in …

Teaching Out Of The Closet: A Qualitative Study To Examine How Queer Educators Navigate Their Professional Work Environments., Brent Braun

Electronic Theses and Dissertations

Queer educators across the nation have faced an onslaught of issues in recent years as they maneuver working in the heteronormative environments of public schools. With the passing of Senate Bill 150 in the Commonwealth of Kentucky in 2023, Kentucky educators became a part of the growing group of educators having to silence themselves within their classroom environments in order to protect their professional careers. This study sought to examine the ways in which queer educators navigate their professional environments in making decisions to either disclose or keep private their identity within the queer community. Semi-structured interviews were completed with …

Linked Lives In The Riverbed: Integrating Fish Host Dynamics, Community Structure, And Demography For Freshwater Mussel Conservation., Jonathan Patrick Frommeyer

Electronic Theses and Dissertations

Freshwater mussels are long-lived benthic invertebrates that play key roles in nutrient cycling, water filtration, and habitat stability in rivers and streams. Despite their ecological importance, they are among the most imperiled faunal groups in North America, with their persistence increasingly threatened by environmental degradation and disruptions to host–parasite dynamics. This dissertation integrates host ecology, community structure, and demographic modeling to assess population viability and guide conservation priorities for mussel species in Kentucky river systems. The first chapter introduces the ecological context and conservation urgency surrounding freshwater mussels. In particular, emphasizing the need for multi-scale approaches to understand how parasitic …

From Afghanistan To Louisville: Changing Face Of Family And Gender Roles In Afghan Immigrants In Louisville, Kentucky., Zohal Ghoura

Electronic Theses and Dissertations

This study explores how Afghan immigrant families navigate gender roles and domestic responsibilities following their migration to the United States. Although current research recognizes the impact of migration on gender norms and labor division in immigrant families, the lived experiences of Afghan families in the United States remain largely unexplored. Based on 12 in-depth semi-structured interviews with Afghan women, this study explores how cultural expectations, economic constraints, and social context shape the division of domestic responsibilities. Findings reveal that migration opened new opportunities for Afghan women, including sense of freedom, access to education and employment opportunities. Exposure to egalitarian values …

Queer Convergence: Figurative Abstraction In Contemporary Art., Vincent Young

Electronic Theses and Dissertations

This thesis is an exhibition text for the exhibition of the same name held in Schneider Hall Galleries from May 15 to August 21st, 2025. This exhibition explores the work of three contemporary artists – Joshua Jenkins, Drew Scanlon, and Lalana Fedorschak – and analyzes their artwork through the lens of Queer Convergence. Queer Convergence is an exploration of abstracted images of bodies and how we can read these bodies through a queer lens, arguing that the visual language of bodily overlap, melding, and transformation shows the physical form as a site of continual change shaped by shared experience and …