Digital Commons Network^™

Accessible Outdoor Recreation For Individuals With Physical Disabilities: An Educational Series, Ashlyn Leonard, Zeida Gutierrez

Summer 2025 OTD Capstone Symposium

This capstone paper explores the effects of physical disabilities on outdoor recreation. An educational workshop was designed and delivered to occupational therapy students at the University of St. Augustine for Health Sciences. The purpose of the workshop was to increase their awareness of accessible outdoor recreation that way they can better mitigate barriers experienced by their future clients when trying to participate in desired outdoor activities. A pre- and post-survey was administered and analyzed to determine the applicability and effectiveness of the workshop in delivering the information.

Habit Formation Among Individuals Alcohol Use Disorder, Blaire Guidry, Cynthia Haynes

Summer 2025 OTD Capstone Symposium

This capstone project aimed to determine the efficacy of a newly developed and delivered online program that focuses on educating individuals experiencing Alcohol Use Disorder (AUD) on how to create habits with decreased executive functioning skills. With the rise in substance use and addiction related disorders throughout the United States, the urge to implement various intervention approaches that support long term recovery is crucial (Radesi, 2025). By focusing on habit formation, the goal of this capstone is to educate individuals on how to create habits that promote increased participation in meaningful occupations.

Applying Trauma-Informed Care Principles For Adolescents That Are Transitioning To College And Work-Life: An Educational Workshop, Annie Patel, Lakeisa Boykin

Summer 2025 OTD Capstone Symposium

Trauma can impact an individual’s ability to function in daily occupations and tasks (SAMHSA, 2014). Traumainformed care focuses on six principles in order to support individuals who have experienced trauma: safety; trustworthiness and transparency; peer support; collaboration and empowerment; choice; and cultural, historical, and gender sensitivity (SAMHSA, 2014). Incorporating these principles allows trauma-informed care to shift the focus from “what is wrong with you?” to “what happened to you?” (Sweeney et al., 2018). This focus allows for a client-centered approach to best assist individuals to address their trauma. 62% of adolescents have been exposed to at least one lifetime traumatic …

Regional Heterogeneity Of The Blood-Brain Barrier, Marie Blanchette, Kaja Bajc, Benjamin D Gastfriend, Caterina P Profaci, Nadine Ruderisch, Cayce E Dorrier, Guo Zhong, Raquel Cuevas-Diaz Duran, Sean S Harvey, Iris H Garcia-Pak, Lucija Pintarić, Manon Leclerc, Louise Reveret, Vincent Émond, Annette Wang, Deepti Pant, Linus T Tsai, Frédéric Calon, Nina Isoherranen, Sean P Palecek, Eric V Shusta, Jiaqian Wu, Richard Daneman

The Brown Foundation: Institute of Molecular Medicine

The blood-brain barrier (BBB), formed by specialized endothelial cells (ECs), regulates the extracellular composition of the central nervous system (CNS). Little is known about whether there are regional specializations of the BBB that may control the function of specific neural circuits. We use single cell RNA-seq to characterize ECs from nine CNS regions in male mice: cortex, hippocampus, cerebellum, spinal cord, striatum, thalamus, hypothalamus, midbrain, and medulla/pons. Although there is a core BBB transcriptional profile, there are significant regional specializations. Stra6, a retinoid transporter, is highly enriched in the BBB of the nucleus accumbens shell (ShNAc) and ventral cochlear nucleus, …

Improving Effective Assistant Nurse Manager Communication In Obstetrics, Julie Marie Glover

Master's Projects and Capstones

Abstract

Problem: This quality improvement project addresses inconsistent leadership communication among Assistant Nurse Managers (ANMs) in the Obstetrics (OB) department of a hospital in Northern California. ANM and staff concerns around shift handoff, huddles, and leadership responsiveness have created confusion and hindered team coordination. The project aims to improve communication effectiveness scores among OB ANMs from 50% to 75% by July 11, 2025.

Context: The project was conducted in the Maternal-Child-Health (MCH) unit of a hospital in Northern California, specifically targeting communication practices among OB ANMs. Concerns around communication practices were voiced by both ANM leadership and frontline staff, signaling …

In Grief We Need Each Other, Derek Schuurman

University Faculty Publications and Creative Works

In the face of grief, human connections provide a far deeper comfort than new AI developments.

Kabasura Kudineer Choornam, A Medicinal Polyherbal Formulation, Modulates Human Macrophage Polarization And Phagocytic Function, Asli Korkmaz, Duygu Ünüvar, Si̇nem Günalp, Derya Göksu Helvaci, Duygu Sağ

Turkish Journal of Biology

Background/aim: Kabasura kudineer choornam (KKC) is a polyherbal formulation of 15 ingredients. It has antiinflammatory and antimicrobial properties and are effective in managing the symptoms of H1N1 swine flu and COVID-19. However, its mechanism of action is not fully understood. In this study, we examined the effect of KKC on the polarization and function of primary human macrophages.

Materials and methods: Human monocyte-derived macrophages (M0 macrophages) pretreated with KKC extract were polarized into M1, M2a, or M2c subtypes. The expression of the M1/M2 polarization markers was analyzed using qPCR, flow cytometry, and ELISA, and the phagocytosis capacity of …

Different Hypoxic Response Of Human Cavii And Caenorhabditis Elegans Homologous Genes Cah-3, Cah-4, Cah-5, Sümeyye Aydoğan Türkoğlu, Aysu Bozkurt, Fatma Poyrazli, Derya Okuyan

Turkish Journal of Biology

Background/aim: A number of carbonic anhydrase (CA) family proteins have been implicated in cancer. They contribute to the hypoxic microenvironment. CAVII is often downregulated in colorectal carcinoma and it has been associated with increased tumor size, node metastasis, and adverse clinical outcomes. In this study, we aimed to investigate the effect of hypoxia on CAVII protein in human colon cancer and prostate cancer cells. In addition, the regulation of CAH genes in Caenorhabditis elegans was examined. These are homologous to CAVII in humans.

Materials and methods: CAVII expression was analyzed in different cell lines such as human colon cancer (SW480 …

Lactic Acid Bacteria Alleviate Neuronal Excitotoxicity And Extend Caenorhabditis Elegans Lifespan, Bao Le, Thi Nhat Hong Nguyen, Seung-Hwan Yang

Turkish Journal of Biology

Aim: Neuronal cell death plays a critical role in the development of neurological disorders associated with aging. This study aimed to evaluate the beneficial effects of heat-killed lactic acid bacteria (hkLAB) on neuroblastoma cells and Caenorhabditis elegans.

Materials and methods: We pretreated heat-killed Lactobacillus fermentum CNU384 (hkCNU384), L. brevis CNU386 (hkCNU386), L. helveticus CNU395 (hkCNU395), and L. paracasei CNU396 (hkCNU396) at a concentration of 10⁹ CFU/mL to investigate their neuroprotective effects on glutamate-induced SH-SY5Y cells and their impact on the lifespan of 6-hydroxydopamine (6-OHDA)-induced C. elegans.

Results: Our findings indicate that hkCNU395 and hkCNU396 protected against glutamate-induced cell death …

Celebrating 20 Years Of Abriendo Oportunidades: Transforming The Lives Of Indigenous Girls In Guatemala, María Isabel Mayorga

Adolescents and Young People

This blog post originally appeared on the Population Council’s website in August 2025.

Education Plan On Colonoscopy Preparation And Communication To Improve Colonoscopy Prep And Ensure Better Outcomes, Maryam Pourjalil

Walden Dissertations and Doctoral Studies

This Doctor of Nursing practice (DNP) staff education project introduced a formalized staff education program to refine colonoscopy preparation quality at a community gastroenterology clinic. Suboptimal bowel preparation in 20%–30% of colonoscopies resulted in missed lesions, higher costs, and decreased satisfaction of the provided quality of care, which highlighted the need for enhanced staff education in nursing practice. The project question was: Does the education of staff on colonoscopy preparation procedures bridge the existing knowledge gap regarding modern colonoscopy techniques? My goal was to increase staff knowledge regarding standardize prep instructions. The project was designed using best practice evidence and …

Mirna-Mediated Regulation Of S100b: A Review, Animesh Dali, Suhana Basnyat, Rachel Delancey, Nipun Chopra

Psychology and Neuroscience Faculty Publications

S100β is a significant signaling molecule and biomarker that is primarily expressed in the brain. At low physiological concentrations, S100β induces astrocyte maturation, microglial migration, and neural proliferation. However, high concentrations activate inflammatory and pro-apoptotic pathways. Due to this dual role, increased research is being invested into the role of S100β in neuronal homeostasis and inflammation. In fact, increased S100β expression is seen in many neuropathologies including Alzheimer’s disease, Parkinson’s disease, cerebral ischemia, and traumatic brain injury. High S100β is generally associated with worsened disease outcome. Here, we provide an overview of the structure and role of S100β in various …

Quality Improvement Project Implementing Comprehensive Foot Exams In Pediatric Patients With Diabetes, Jimmy Penn

Doctor of Nursing Practice Projects

Pediatric patients with diabetes face many of the same long-term complications as adults, including neuropathy. Yet screenings are often overlooked in this population. Research shows that pediatric patients with diabetes experience neuropathy symptoms, yet screening in this population remains underperformed. The purpose of this quality improvement project was to implement a comprehensive foot exam for eligible pediatric patients with diabetes and improve provider adherence through education. The project addressed the question: “Among providers in a pediatric endocrinology clinic, how does implementing education on foot exams, compared to no education, impact provider knowledge and compliance with performing pediatric foot exams over …

Routine Outcome Monitoring With The Youth Outcome Questionnaire-30.2 Self-Report: Creating And Testing An Empirical Alert System And Exploring Informant Discrepancy Patterns, Tate M. Paxton

Theses and Dissertations

Objective: Youth self-report data using the YOQ-30 has not been specifically examined for use in routine outcome monitoring systems. This study used the YOQ-30 self-report in three endeavors: (1) modeling change trajectories in a large, naturalistic outpatient sample, (2) creating and testing an empirical alert system for deterioration, and (3) exploring the role of informant agreement, both descriptively and in a change trajectory model. Method: The sample consisted of 21,098 adolescents ages 12-17 receiving outpatient mental health care who used the OQ Measures system. Multilevel individual change trajectory models estimated symptom change over time. An alert system was developed on …

Attachment Or Aversion: A Study Of The Effects Of Parental Technoference On Child Emotion Knowledge, Brooklyn Coleman

Theses and Dissertations

Young children's understanding of emotions is heavily socialized by their parents. Through interactions with parents, children learn what emotions look like, when they are expressed, and how they are labeled (Laible, 2004a). Interruptions to interactions between children and parents have the potential to influence the development of children's emotion knowledge. According to the DREAMER framework, how one family member uses media and technology can influence other family members (Barr et al., 2024). Technoference (i.e., digital distraction while with others) is one example of how media might interrupt family life and influence child development as a whole. The current study examined …

Wellness Tourism: An Introduction, Karen Thal

All Open Educational Resources

Wellness tourism is a growing segment of the travel industry that focuses on experiences designed to improve physical, psychological, and spiritual well-being. From yoga retreats and spa getaways to outdoor adventures and healthy culinary experiences, this form of tourism reflects a broader cultural shift toward self-care and holistic health. The current textbook introduces wellness tourism in a U.S. context, offering a practical, business oriented overview for undergraduate students. It provides insights into the concept of wellness, defines and examines both the wellness industry and the wellness tourism sub-sector, highlights key trends, explores the motivations of wellness travelers, and explains how …

Refugee Families: Parental Traumatic Stress And Child Outcomes A Scoping Review, Britta Sedig

Theses and Dissertations

This scoping review synthesizes recent literature (2019-2024) to explore mechanisms linking parental trauma to child mental health outcomes within refugee families. Guided by a systemic and relational focus, 20 studies were identified and analyzed, revealing five central themes: intergenerational transmission of trauma, parenting practices as mediators, parent-child dyadic attachment, family functioning and conflict, and post-migration and acculturative stress. Findings highlighted associations between parental trauma-related symptoms and refugee children's emotional and behavioral concerns. Parenting practices were frequently linked to child wellbeing, with some studies identifying risk factors like harsh discipline and emotional unavailability, and others noting protective roles of intentional caregiving. …

Navigating Ai Ethics Through The Lens Of Personality Traits And Well-Being: Policy Recommendations For Young People In The Uae, Areej Elsayary

All Works

The main purpose of this study is to explore the relationship between HEXACO personality traits and well-being, using ethical AI as a mediator among young adults in the UAE, aiming to develop policy recommendations that support ethical AI practices in educational settings. Utilizing a quantitative cross-sectional design, the study involved 204 university students in the UAE, aged 18 and above (M = 23.8, SD = 5.64), with 71 (34.8%) being males and 133 (65.2%) being females. The findings reveal the significant role of AI ethical use in mediating the relationship between certain HEXACO personality traits (honesty–humility, emotionality, and agreeableness) and …

Stability Of Micrornas In Serum And Plasma Reveal Promise As A Circulating Biomarker, Erryk S. Katayama, Jonathan J. Hue, Alexander W. Loftus, Semmer A. Ali, Hallie J. Graor, Luke D. Rothermel, Eric R. Londin, Mehrdad Zarei, Jordan M. Winter

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

PURPOSE: To verify the stability and reliability of circulating microRNA (miRNA) profiles in plasma and serum under different processing and storage conditions to inform future applications to circulating biomarker analyses.

BACKGROUND: The development of blood-based methods for early disease detection has become increasingly desirable across various medical fields. RNA profiles have been investigated but have been a challenge due to rapid degradation of the analyte by ubiquitous RNases. miRNAs are short, non-coding regulatory RNAs that are believed to be more stable under certain conditions, large in number, and specific to cell type and disease state. Thus, circulating miRNA profiles hold …

The Use Of A Horizontal Reference Line While Measuring The Anterior Center Edge Angle Is More Reliable Than The Traditional Method, Roland Howard, Benjamin Miltenberg, William Johns, Neel Patel, Shyam Brahmabhatt, John Salvo

Rothman Institute Papers

BACKGROUND: The anterior center edge angle (ACEA) is a radiographic parameter commonly utilized for the assessment of anterior acetabular coverage in the setting of various hip abnormalities. However, this measurement is greatly dependent on patient positioning and imaging technique.

PURPOSE: To evaluate the utility of a measurement technique utilizing a horizontal reference line and femoral head perfect circles for better control of pelvic obliquity and the assessment of its potential as a more reproducible method for determining the ACEA.

STUDY DESIGN: Cohort study (diagnosis); Level of evidence, 3.

METHODS: There were 3 authors who retrospectively reviewed the false-profile radiographs of …

Under What Conditions? A University Pathway Program Evaluation, Michael Burke

Electronic Theses and Dissertations

As U.S. universities face a declining domestic applicant pool, commonly referred to as the “enrollment cliff,” international student recruitment provides a practical strategy for offsetting domestic enrollment shortfalls. One such strategy for increasing international student enrollment is through the establishment of university pathway programs that grant conditional admission to international applicants who fail to meet English language proficiency requirements but are otherwise academically admissible. As a baseline program evaluation, this study utilized a quantitative methods approach employing logistical regression analysis to determine if incoming standardized English language proficiency test scores, English as a Second Language (ESL) course GPA, and student …

Sociodemographic, Neighborhood-Level, And Health-Related Factors Associated With Progression To Bariatric Surgery: A Retrospective Chart Review., Angela Godwin

Electronic Theses and Dissertations

Background: Bariatric surgery is the most effective treatment for patients with Class 3 obesity. However, of individuals who start the bariatric surgical process, only about half undergo surgery. Factors associated with completion, including race, have been described; however, consistent evidence on obstacles remains to be identified.

Objectives: To explore variables based on the Social Ecological Model (SEM) that may be related to bariatric surgery completion.

Setting: A large, private hospital with a Bariatric Center of Excellence in New York City

Methods: This retrospective chart review utilized data from adults who established an initial bariatric surgery visit from April 1, 2012, …

Describing Latent Tuberculosis Infection And Treatment Completion In Virginia: A Social Determinants Of Health Approach, Amber N. Harmon

Electronic Theses and Dissertations

While the treatment of latent tuberculosis infection is a key strategy in tuberculosis elimination nationally and globally, there is a limited understanding of the general prevalence of latent tuberculosis as well as factors related to successful treatment. This dissertation describes the known landscape of latent tuberculosis in Virginia and explores possible factors related to latent tuberculosis infection treatment through three manuscripts. The first manuscript, Chapter 1, outlines the overall proposal for this dissertation research in the style of a National Institute of Health grant proposal. The second manuscript, Chapter 2, describes the current understanding of the factors related to latent …

Adding Varying Degrees Of Performance Feedback Components To The Taped Problems Intervention, Alyson C. Honaker

Electronic Theses and Dissertations

Math fact fluency, the ability to quickly and accurately solve one-digit by one-digit math problems, is a common challenge for many school-aged children. Difficulties with fluency often lead to reliance on inefficient strategies, hindering progress in more advanced math skills. Evidence-based interventions like Taped Problems Intervention (TPI) have demonstrated effectiveness in improving math fluency. However, research suggests incorporating behavioral components such as Performance feedback (PF) and goal setting/reinforcement (GS/R) may enhance its effectiveness. The present study used a multiple-probe across-task design to evaluate the effects of three variations of TPI on the subtraction fluency of five elementary students in a …

Exploration Of The Cultural Beliefs, Values, And Practices Of African American/Black Women Or Birthing Persons Regarding Postpartum Depression: A Focused Ethnography, Stephanie Jacobs

Electronic Theses and Dissertations

Introduction: Postpartum depression (PPD) is the most prevalent perinatal mental health illness in women, affecting approximately 10% to 20% of all women in the United States, and a disproportionately higher number of African American women. The aim of this study was to explore the cultural beliefs, values, and practices of African American/Black women or birthing persons regarding postpartum depression.

Research Question: What are the cultural beliefs, values, and practices of African American/Black women or birthing persons regarding postpartum depression?

Methodology: A focused ethnography was chosen for this study and consisted of semi-structured interviews. Data was transcribed and analyzed …

The Application Of Macrophage-Targeted, Anti-Inflammatory Celecoxib Nanoemulgel For Nerve Regeneration In Peripheral Nerve Injury, Lu Liu

Electronic Theses and Dissertations

Peripheral nerve injury (PNI) refers to damage to the nerve located outside the brain and spinal cord. PNI is commonly caused by a physical accident (trauma) or medical operation^{1, 2}. The impact on the quality of life of PNI patients is directly correlated to neuropathic pain, resultant depression, and increased stress². Even after recovering from the PNI, patients still experience phantom pain and lose the ability to work due to the loss of tactile sensory or motor function^2-4. However, unlike damage to the central nervous system (CNS), peripheral nerves can regenerate because macrophages clean …

Eco-Emotions And Climate Activism In Adolescents, Julianna Sahoo

Master's Projects and Capstones

Background. Youth are especially vulnerable to climate change, both physically and psychologically. Combatting climate change will require a coordinated, global effort. Understanding the motivations and emotions behind climate activism is essential to coordinate efforts to combat climate change.

Methods. This research uses survey data collected from first and second year undergraduates (n=521) at a private, urban university in California in the Fall of 2022. Youth were surveyed on emotions related to climate change, activism, compassion, eco-anxiety, and well-being.

Results. Experiencing positive emotions had a stronger relationship with environmental activism compared to negative emotions.

Conclusion. Results suggest climate change communications should …

Reducing Nulliparous, Term, Singleton, Vertex Cesarean Birth Rate, Roseanna Juarez

Master's Projects and Capstones

Abstract

Problem: Cesarean birth rates for nulliparous, term, singleton, vertex (NTSV) pregnancies in the United States continue to exceed the Healthy People 2030 goal of 23.6%, resulting in preventable maternal and neonatal complications and higher healthcare costs.

Context: This quality improvement (QI) initiative was conducted in a high-acuity labor and delivery unit in California’s Central Valley, an area characterized by maternal health disparities, high rates of comorbidities, and limited access to prenatal care. The goal was to reduce the NTSV cesarean rate to 18.0% by July 31, 2025.

Interventions: Guided by Kotter’s 8-Step Change Theory and the Plan-Do-Study-Act (PDSA) framework, …

Mental Health And Substance Use Interventions Within Muslim Community Spaces: A Community Based-Participatory Research Proposal, Halah Mansour Alayleh

Master's Projects and Capstones

Background. Muslim Americans face significant mental health and substance use challenges compounded by Islamophobic discrimination, cultural stigma, and barriers to accessing culturally competent services. They also significantly underuse professional mental health services. Purpose. This study aims to collaborate with Muslim communities within the San Francisco Bay Area to develop a replicable intervention framework for addressing mental health and substance use stigma within mosques and other Muslim community spaces. Methods. The proposal uses a community-based participatory research (CBPR) methodology while integrating the theory of planned behavior (TPB) and stigma theory in the framework. This proposal outlines the four phases of intervention …

Promoting Inclusion Through Evidence-Based Behavior Management: Effective Interventions For Students With Asd In General Education, Emma Kaiser

Masters Projects

As diagnoses of autism spectrum disorder (ASD) continue to rise, general education classrooms are increasingly responsible for meeting the needs of students with ASD. However, many teachers lack the training and resources necessary to manage challenging behaviors effectively. This knowledge gap often results in exclusionary practices such as restraint, seclusion, and suspension, which act as barriers to inclusion. The purpose of this project is to equip educators with evidence-based behavior management strategies that support inclusive practices. Drawing from current research, the project organizes effective interventions into three key categories: preventing challenging behaviors, teaching alternative skills, and reinforcing positive behaviors. Each …