Digital Commons Network^™

Epilepsy-Associated Digenic Variants Affecting An Actin-Mitochondria-Glutamate Pathway Promote Seizure Susceptibility, Shenzhao Lu, Mengqi Ma, Shabab B Hannan, Mingxi Deng, Hu Chen, Zhijian Yu, Lindsey D Goodman, Haein Kim, Yun Zhao, Sandeep Kumar Dubey, Wen-Wen Lin, Xueyang Pan, Debdeep Dutta, Vishnu Anand Cuddapah, Jill A Rosenfeld, Xi Luo, Zhandong Liu, Joshua M Shulman, Hugo J Bellen

Faculty, Staff and Students Publications

Epilepsy affects approximately 50 million people worldwide, yet more than half of individuals with a presumed genetic cause still lack a molecular diagnosis despite the identification of over 1,000 monogenic epilepsy genes. This diagnostic gap is unlikely to be resolved by improved variant detection alone, suggesting that variants affecting the same biological pathway may combine to cause disease. By studying epilepsy-associated actin regulatory genes, we identified a conserved "actin-mitochondria-glutamate (AMG) pathway". We demonstrate that reduced actin polymerization promotes DRP1-mediated mitochondrial fission, increases reactive oxygen species (ROS) levels, and enhances glutamatergic transmission, leading to seizures. The glial innate immune pathway, a …

Harmful Algal Blooms: Risks For Food In Utah, Jose Brandao, Sarah Erwin, Stephanie Vaughn, Clare Entwistle

All Current Publications

Harmful algal blooms (HABs) are a problem because they can produce toxins that make water unsafe for people, animals, and the environment. In recent years, HABs have emerged as a growing concern in freshwater systems throughout Utah, including irrigation canals, reservoirs, and livestock ponds. HABs in freshwater are caused by cyanobacteria, also called blue-green algae. These microorganisms can release dangerous toxins that can harm swimmers, pets, and the food supply. Unlike foodborne pathogens, these toxins cannot be removed by boiling, cooking, or washing the food. Therefore, regular monitoring is essential to detect HABs early and reduce exposure risks. This fact …

Sober Curiosity Among Lgbtq+ Women And Non-Binary People In Aotearoa New Zealand, Tonda L. Hughes, Jillian R. Scheer, Lauren Bochicchio, Laurie A. Drabble, Carol Emslie, David Whiteley, Belinda Lunnay, Paul R. Ward, Antonia C. Lyons

Faculty Research, Scholarly, and Creative Activity

Background: Although global drinking rates are declining, this trend is less evident among women, with LGBTQ+ women and nonbinary people at elevated risk for hazardous drinking. In addition to minority stress (e.g., stigma, discrimination), drinking culture and social norms likely shape alcohol use within these groups, yet remain underexplored as potential intervention points. Objective: This study was part of a larger multi-country project on alcohol use among LGBTQ+ women and nonbinary individuals. Because online resources have been found to appeal to stigmatized groups, we aimed to examine LGBTQ+ women’s and nonbinary people’s experiences with alcohol use in Aotearoa New Zealand, …

Assessing Current Non-Pharmacologic Pain Management Practices For Sickle Cell Disease In Adults, Shreya Kolipaka, Michelle Axe, Charmaine Wright, Stephanie Guarino

Student Papers, Posters & Projects

OBJECTIVES: Both acute and chronic pain caused by sickle cell disease (SCD) is often managed with opioid therapy despite limited evidence for long-term efficacy. Adequately managing SCD pain requires a comprehensive approach, incorporating both pharmacologic and non-pharmacologic interventions. In other conditions, peer-mentored group programs are effective in managing chronic pain; however, their role in SCD is not yet described. Our objective is to understand patients' current pharmacologic and non-pharmacologic SCD management practices as well as further exploring perspectives of pain related to SCD.

METHODS: Participants were interviewed using semi-structured format. Audio-recorded interviews were transcribed. Descriptive statistics and pain management modality …

Vda Governance Meeting 2011

Virginia Dental Journal

No abstract provided.

An Interview With- Dr. Carole Pratt, A. Carole Pratt Dds

Virginia Dental Journal

No abstract provided.

Our Weekend In Wise County, Virginia, David Rothkopf Dds

Virginia Dental Journal

No abstract provided.

Special Olympics, Special Smiles In Virginia, Matthew R. Cooke Dmd

Virginia Dental Journal

No abstract provided.

Make Your Practice A Masterpiece, Tanya A. Brown Dmd, Laura Edwards

Virginia Dental Journal

No abstract provided.

A Tale Of Two Continents-My Experience At Orthodontics At Vcu, Ahmad M. Hamdan Dds

Virginia Dental Journal

No abstract provided.

Va Dent J October, November And December 2011

Virginia Dental Journal

No abstract provided.

Vcu Oral And Facial Surgery- A Higher Purpose, Robert Strauss Dds

Virginia Dental Journal

No abstract provided.

Why Research In The Dental School Is Important, David C. Sarrett Dmd

Virginia Dental Journal

No abstract provided.

Community Based Dental Education And Service-Learning At Vcu School Of Dentistry, Kim T. Isringhausen Bsdh, Rdh, Mph

Virginia Dental Journal

No abstract provided.

Vda's Legislative Day On The Hill - Vadpac Update

Virginia Dental Journal

No abstract provided.

Trustee's Corner, Charles H. Norman Iii, Dds

Virginia Dental Journal

No abstract provided.

An Interview With Dr. Roger Wood, Roger Wood Dds

Virginia Dental Journal

No abstract provided.

Letter To The Editor, Marvin E. Pizer Dds, Ms, Ma, Ficd

Virginia Dental Journal

No abstract provided.

Message From The Editor, Richard F. Roadcap Dds

Virginia Dental Journal

No abstract provided.

Message From The President, Roger Wood Dds

Virginia Dental Journal

No abstract provided.

Using Fiction To Teach About Reproductive Control, Julie Shayne

Feminist Pedagogy

This essay is a short discussion of two new novels about reproductive rights denied: Enormous Wings by Laurie Frankel and Where the Girls Were by Kate Schatz. In it, I offer very abbreviated summaries of the books and a discussion of why novels are useful in social science classrooms.

The Unfixing: A Review For The Feminist Classroom, Aj Castle

Feminist Pedagogy

No abstract provided.

Documentary Review: The Devil Is Busy, Margaret A. Murray

Feminist Pedagogy

The Devils is Busy is an Oscar-nominated documentary short that goes behind the scenes at the Feminist Center for Reproductive Liberation in Atlanta, GA. The viewer accompanies the clinic’s head of security, Tracii, as she spends a day protecting the clinic. The film is a thoughtful, restrained look at an important topic. This review will provide some context for the film, summarize it and suggest how it could be used in class.

Social Justice Strategies For Teaching During The ‘Anxiety Crisis’, Maggie Mang, Kerry Smith-Saxman

Feminist Pedagogy

These authors describe their teaching strategies for accounting for anxiety in pedagogy. The instructors describe creating space for students' affective experiences when writing and countering ableism in course instruction.

Access Intimacy In The Feminist Classroom: Co-Creating Course Policies, Expectations, And Access Measures As Feminist Disability Praxis, Krystal Cleary

Feminist Pedagogy

In this essay, I outline an activity to foster access intimacy (Mingus, 2011) in the feminist classroom through students’ co-creation of course policies, expectations, and additional access measures. This activity transforms the classroom into a praxis laboratory wherein students analyze the normative structures that shape their hyperlocal classroom context and practice building environments characterized by interdependent solidarity rather than atomized competition. As feminist disability praxis, this activity centers the knowledge of disabled, chronically ill, and neurodivergent scholars and students; in doing so, it customizes the classroom to a diversity of learners and builds adaptability for responding to unforeseen challenges into …

Liberation Landscapes: Writing Freedom In A Black Geographies Classroom, Cornel Grey, Muna-Udbi A. Ali

Feminist Pedagogy

No abstract provided.

The Bonga Collection And The Carleton And York Regiment Veterans Of The Liberation Of The Netherlands, Mackenzie Smith

Canadian Military History

The Dr. Agatha Bonga Memorial Collection contains over one thousand questionnaires completed by Canadian Second World War veterans surrounding the liberation of the Netherlands and is currently held in The Gregg Centre for the Study of War and Society at the University of New Brunswick. Focusing on the narratives of three veteran respondents, James Agnew, Donald Smith and R.O. Steeves, this article shows how veterans’ answers to the questionnaires creates a historical record of the attitudes, emotions and experiences of those who served in the Netherlands and survived the Second World War. When these narratives are examined with the eighteen …

The Cognitive Dimension Of Mobilization—Reconsidering American War Preparation In An Age Of Persistent Cognitive Warfare, Robert "Jake" Bebber

Naval War College Review

American war mobilization doctrine is built on an industrial-era paradigm that assumes the primary contest is material: who can most efficiently convert economic capacity into military power. An evaluation suggests that this paradigm, while necessary, is no longer sufficient.

The Purity Crusader, Volume 21. Number 8, November 1924

Berachah Home Collection

"The Purity Crusader" published by Berachah Rescue Society in Arlington, Texas. Volume 21, Number 8. A newsletter with articles written from various persons regarding purity and life at Berachah Home. Published in November 1924.

Water Scarcity On Arizona’S Navajo Nation, As An Environmental Justice Issue, Chenoa Marks

Scholarly Horizons: University of Minnesota, Morris Undergraduate Journal

For the Navajo–or Diné, meaning ‘the people’ in Diné Bizaad (Navajo language)–water is not only a resource. It is life, story, and relationship. It is tied to origin, movement, and balance within the natural and spiritual world. Water exists not only in rivers and rainfall, but in teachings, ceremonies, and the way knowledge is passed down from one generation to the next. In this sense, water is both physical and cultural, shaping how people live, understand the land, and connect to one another.

At the same time, water on the Navajo Nation–known by the Diné as Diné Bikéyah, also translated …