Digital Commons Network^™

Biophysical Effects Of Altered Myosin Binding Protein Stoichiometry In Atrial Myofilaments, Kelly N. Araujo

Dissertations

Cardiomyopathies, such as hypertrophic and dilated subtypes, are leading causes of heart failure and are often driven by genetic mutations that disrupt the structure and function of the cardiac sarcomere. While much of the research has focused on ventricular involvement, the role of atrial sarcomere dysfunction remains unexplored. The regulation of contractile function by sarcomeric proteins in the atria remains poorly understood, especially the impact of protein stoichiometry among myosin binding proteins. Cardiac myosin binding protein-C (cMyBP-C) and its atrial paralog, myosin binding protein H-like (MyBP-HL), have been shown to have a stoichiometric relationship within the atrial sarcomere. These two …

Black Mothers' Adhd Experiences, Attitudes, And Support-Seeking Decisions, Catherine L. Montgomery

Dissertations - ALL

Background: ADHD, particularly when left untreated, is associated with significant impairment in several domains. Black youth may still be under-diagnosed with ADHD, resulting in symptoms going untreated. Black mothers may determine non-professional delivered supports to be more appropriate and acceptable than medication for their children with ADHD. As they tend to be the primary healthcare decision makers, it is important to develop a greater understanding of Black mothers’ ADHD support-seeking decision making for their youth. Method: The present study used semi-structured interviews guided by Kleinman’s Explanatory Models of Illness to discuss Black mothers’ decision making for their youth with ADHD. …

Pain Intensity And Alcohol Use Behavior Among Veterans With Chronic Pain: The Moderating Role Of Chronic Pain Acceptance, Kyle White

Dissertations - ALL

The co-occurrence of chronic pain and unhealthy alcohol use is common among veterans and associated with worse treatment outcomes and greater functional impairment relative to either condition alone. Accordingly, the U.S. Department of Veterans Affairs (VA) has underscored the importance of addressing co-occurring medical conditions in their clinical practice guidelines for substance-related disorders. Recent legislation has also oriented the VA towards complementary and integrative health therapies to minimize opioid prescriptions for chronic pain. Thus, identifying malleable psychological factors linking pain to alcohol use is a vital step in the development of tailored interventions for veterans. The goal of the current …

The Impact Of Adhd On Entrepreneurship Through A Gender Lens Three Essays, Mi Hoang Tran

Dissertations - ALL

This dissertation investigates how neurodiversity, specifically attention-deficit/hyperactivity disorder (ADHD), relates to entrepreneurial behaviors and outcomes, with a specific attention to gender as a moderating factor. The first essay provides a comprehensive meta-analytic review of 44 empirical studies, synthesizing 261 effect sizes to assess the relationship between ADHD and different stages of the entrepreneurial process: attitudes, behaviors, and post-launch outcomes. Results reveal that hyperactivity/impulsivity symptoms are positively associated with entrepreneurial attitudes and behaviors but unrelated to post-launch outcomes, while inattention symptoms are negatively associated with outcomes. These findings offer evidence that ADHD’s impact is phase-specific and contingent. The second essay draws …

Mental Health, Physical Activity, And Cardiovascular Disease Risk In International Migrant Populations, Andrew Rodriguez Heckel

Dissertations - ALL

International migrant populations, including immigrants, refugees, and international students, are a growing population worldwide that may be vulnerable to a heightened cardiovascular disease risk. Lifestyle factors, such as poor mental health and physical inactivity, may worsen cardiovascular disease risk factors that, in turn, increase cardiovascular disease risk. We sought to examine measures of cardiovascular disease risk and the lifestyle factors that may be affecting these measures in international migrant populations. In study 1, we compared hypertension prevalence between adult immigrants and non-immigrants in the United States. We found a lower hypertension prevalence in immigrants, which was mediated by their lower …

Quantify The Impact Of Occupant Behavior On Building Retrofits To Achieve Net-Zero Target Under Future Climates, Pratik Raj Pandey

Dissertations - ALL

It is estimated that about 40% of all the electricity generated in the United States is consumed by the building sector. This scale of energy use by buildings can be understood by the fact that the U.S. alone consumes approximately 20% of all the energy produced globally, despite having only about 4.23% of the world's population. Given the threats posed by climate change, it is necessary to curtail the energy demand of this sector. Additionally, global climate change has increased the frequency, intensity, and duration of extreme climate events like heat waves, cold waves, hurricanes, floods, and droughts. Given the …

Development, Validation, And Applicability Of A Race-Specific Insulin Sensitivity Estimator (Rise) In Youth And Young Adults, Wonhee Cho

Dissertations - ALL

Parallel to the escalating rate of overweight and obesity in the youth and young adult population, the incidence and prevalence of type 2 diabetes are also mounting, presenting significant public health problems. Among the various pathophysiological factors, insulin sensitivity has emerged as a critical risk factor for impaired glucose tolerance (IGT) and type 2 diabetes in youth. Despite the pivotal role of insulin sensitivity in the development and progression of these conditions, current methodologies for its assessment, such as the hyperinsulinemic-euglycemic clamp and intravenous glucose tolerance test, are limited by their invasive methods, high cost, and unsuitability for use in …

An Examination Of The Opt Out Movement In New York State, Selene M. Cammer-Bechtold

Dissertations - ALL

Public state education systems are required by federal law to assess student learning in order to receive certain federal funding for the state’s education system. Typically, the metric are standardized testing regimes. New York State is no exception and requires students in grades 3-8 to take annual English Language Arts and Mathematics exams to meet that requirement. However, New York State is a unique case, as it has the highest Opt Out rate, or noncompliance on taking the exams, in the country. While the majority of the literature on the Opt Out Movement has focused on who is more likely …

Caf-Macrophage Crosstalk Fuels Immunotherapy Resistance, Yang Liu, Linghua Wang

Faculty, Staff and Student Publications

No abstract provided.

Safety Of Contemporary Radiation Therapy In Patients With Cardiac Implantable Electronic Devices: Implications For Clinical Practice, Kaveh Karimzad, Shalin Shah, Stephen F Kry, Christopher Peeler, Julianne Pollard-Larkin, Amit Koduri, Martin Chacon Portillo, Siddharth Chauhan, Atia Amatullah, Chase Miller, Amanda Strang, Juhee Song, Khatera Mir Zaman Shah, Donelo Lopez, Darla Wagner, January Tsai, Shital Vachhani, Dilip Thakar, Cezar Iliescu, Jean-Bernard Durand, Anne H Dougherty, Bharat Kantharia, Anita Deswal

Faculty, Staff and Student Publications

Background: Radiation therapy (RT) can cause cardiac implantable electronic device (CIED) malfunction, primarily reset. Given changes in RT and CIED technologies, large observational studies examining malfunction of contemporary CIEDs during modern-day RT are needed to guide clinical practice.

Methods: Electronic medical records of all consecutive patients with CIEDs who underwent RT at a large tertiary cancer center between January 2015 and January 2022 were reviewed. All patients had CIED interrogation before and after completion of RT. Device-related data and RT-specific variables were collected. Statistical analyses were performed at the RT course level.

Results: Over a period of 7 years, 677 …

A Multimodal Approach To Assess A Liposomal Carrier’S Biodistribution, Stability, And Clearance, Cayla A Wood, Claire E Jones, Ananthakrishnan Soundaram Jeevarathinam, Riley Watson, Sangheon Han, Jennifer Meyer, Konstantin V Sokolov, Richard R Bouchard

Faculty, Staff and Student Publications

Liposomal carriers, used for site-specific drug delivery, are being investigated for diagnostic approaches by replacing the therapeutic with an imaging contrast agent, exploring potential for selective treatment planning. There remains a critical need to improve in vivo assessment of biodistribution, stability, and clearance kinetics of liposomal carriers. This pilot study presents a multimodal approach in which liposome-encapsulated J-aggregated indocyanine green (ICG) dye (Lipo-JICG) is imaged with high spatial resolution using both in vivo photoacoustic (PA) imaging, to assess the absorbance characteristics of JICG and monomeric ICG, and ex vivo cryofluorescence tomography (CFT), to measure ICG fluorescence. An in vitro assay …

Ectopic Adipose Tissue In Subsistence Populations With Minimal Coronary Disease, Large Left Atria, And Very Low Rates Of Atrial Fibrillation, Randall C. Thompson, Benjamin C. Trumble, Daniel K. Cummings, Angela D. Neunuebel, Paul L. Hooper, Samuel Wann, Adel H. Allam, Frances Neunuebel, Benjamin D. Gans, Samantha I. King, Edmond Seabright, Caleb E. Finch, Margaret Gatz, Kenneth Buetow, Michael I. Miyamoto, Guido P. Lombardi, M. Linda Sutherland, James D. Sutherland, Christopher J. Ward, Madeleine J. Lee, Ashna Mahadev, Daniel Eid Rodriguez, David E. Michalik, Chris J. Rowan, Tianyu Cao, Jonathan Stieglitz, Cameron M. Quick, Gregory S. Thomas, Jagat Narula, Damini Dey, Michael Gurven, Hillard Kaplan

ESI Publications

Background

Methods

Challenging Life Events Of Undergraduate Students, Kristi Lewis, Gayle Roux, Catherine Dingley

The Qualitative Report

College students often face many difficult or stressful personal life events such as academic pressure, financial worries, family stress, or a relationship breakup. These events can impact their mental health and academic performance. Amid the growing mental health crisis on college campuses, it is important to explore the strategies that college students employ to tackle challenging life events. The purpose of this study was to (1) explore the experience of college undergraduates as they navigate challenging life events; and (2) examine strategies and resources utilized by the students. We conducted a qualitative descriptive study informed by phenomenology (Giorgi, 2009) using …

A 6-Month, Prospective Randomized Controlled Trial Of The Targeted Management (Team) Intervention Vs. Enhanced Treatment As Usual Among Ugandans At Risk For Stroke, Carla Conroy, Joy Yala, Christopher J. Burant, Shirley Moore, Martha Sajatovic

Faculty Scholarship

Background Among low and middle-income countries, especially in Sub-Saharan Africa, the stroke burden is severe, with increasing trends in stroke incidence, prevalence, and mortality. Aims This 6-month, prospective randomized controlled trial (RCT) compared a novel stroke risk reduction approach (TargetEd manAgeMent Intervention (TEAM)) vs. Enhanced Treatment as Usual (ETAU) in 247 Ugandans at risk for stroke. Methods Participants, enrolled across 3 Ugandan sites, were adults with high stroke risk. The primary outcome was a change in systolic blood pressure (SBP) from baseline to 6-month follow-up. Secondary outcomes included changes from baseline to 6 months on diastolic BP (DBP), serum lipids, …

Re: Approval Letter For The Butte Priority Soils Operable Unit (Bpsou) Butte Treatment Lagoons (Btl) Groundwater Treatment System Quarterly Operation And Maintenance Report – Quarter 1 2025 (Dated June 30, 2025), Emma Rott

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Re: Approval Letter For Butte Priority Soils Operable Unit (Bpsou) Superfund Operation And Maintenance (O&M) Request For Maintenance – Kelley Stormwater Channels (Revised On July 23, 2025), Emma Rott

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

The 10-Year Anniversary Of The Dissemination And Implementation Models In Health Interactive Webtool: History, Refinement, Use, And Guidance, Borsika A Rabin, Bryan Ford, Rachel G Tabak, Rebekah Gomes, Kera N Swanson, Sara Malone, Maggie Padek Kalman, Ross C Brownson, Russell E Glasgow

2020-Current year OA Pubs

Theories, models, and frameworks (TMFs) are essential tools in dissemination and implementation (D&I) research, yet selecting and applying the most appropriate TMF is routinely a challenge, particularly for those new to the field. To address this need, we developed the

Targeting Fear Of Cancer Recurrence With Internet-Based Emotional Freedom Techniques (Ieft) And Mindfulness Meditation Intervention (Immi) (Bgog-Gyn1b/Remote), Laura Tack, Lore Mertens, Marte Vandeweyer, Fien Florin, Emma Pauwels, Thaïs Baert, Tom Boterberg, Christel Fontaine, Kurt Geldhof, Caroline Lamot, Christine Langenaeken, Jeroen Mebis, Laure-Anne Teuwen, Katherine Vandenborre, Heidi Van Den Bulck, Florence Van Ryckeghem, Mohammad Najlah, Patricia Schofield, Philip R. Debruyne

School of Nursing and Midwifery

Approximately one-third of cancer survivors report a need for professional help to cope with Fear of Cancer Recurrence (FCR). In the REMOTE trial, we aim to investigate the efficacy of two internet-based mind-body techniques to address this currently unmet medical need. Cancer survivors, screened using the Cancer Worry Scale (CWS), are randomly assigned to one of the three study groups: (1) internet-based emotional freedom techniques (iEFT) (n = 113), (2) an active control condition internet-based mindfulness meditation intervention (iMMI) (n = 113), or (3) a wait-list control group (WLC) (n = 113). The interventions iEFT and iMMI are conducted remotely …

Spina Bifida: Home Post-Operative Care, Preetha Prazad

Advocate GME

No abstract provided.

Multivariate Protein Landscape Of Host Response In Hospitalised Patients With Suspected Infection In The Emergency Department, Pratik Sinha, Et Al.

2020-Current year OA Pubs

Suspected infection requiring hospitalisation has highly heterogenous presentation. Yet, variances in host response and its implications are largely unknown. In this multicentre cohort of 3802 individual patients presenting to the Emergency Department (ED) with suspected infection requiring hospitalisation, we apply uniform manifold approximation and projections and K-means clustering to 29 plasma proteins to identify biologically discrete host response clusters. In this work, we first describe two large clusters, called "Dysregulated" and "Undifferentiated", with abnormal protein concentrations and adverse outcomes in the former. Through further clustering, we identify 4 sub-clusters in the Dysregulated cluster, each with discrete biological signatures, clinical correlates, …

Factors Associated With Adolescents' Self-Efficacy To Meet With Their Health Care Provider Alone, Albert C Hergenroeder, Blanca Sanchez-Fournier, Cassandra Enzler, Mary Majumder, Beth H Garland, Constance M Wiemann

Center for Medical Ethics and Health Policy Staff Publications

Adolescents with special health care needs (ASHCNs) must develop self-management skills to effectively transition into adult-based care. This requires having the self-efficacy to meet with their health care provider independent of caregivers. This study aims to identify the factors associated with self-efficacy in meeting with a provider alone among ASHCN preparing for this transition.Eighty-three English-speaking 18-year olds with renal, gastrointestinal, neurologic, or rheumatologic diseases, and their English- or Spanish-speaking caregivers were recruited at a large children's hospital, and completed a one-time assessment as the historical control group for a larger intervention study. The main outcome measure was self-efficacy to meet …

Prolonging Lung Cancer Response To Egfr Inhibition By Targeting The Selective Advantage Of Resistant Cells, Lisa Brunet, David Alexandre, Jiyoung Lee, Maria Del Mar Blanquer-Rosselló, David Bracquemond, Alexis Guernet, Houssein Chhouri, Mathilde Goupil, Zoulika Kherrouche, Arnaud Arabo, Maicol Mancini, Dorthe Cartier, Shen Yao, David Godefroy, Julie Dehedin, Jian-Rong Li, Céline Duparc, Philippe Jamme, Audrey Vinchent, Caroline Bérard, David Tulasne, Sabrina Arena, Alberto Bardelli, Chao Cheng, Byoung Chul Cho, Olivier Wurtz, Cédric Coulouarn, Antonio Maraver, Stuart A Aaronson, Alexis B Cortot, Youssef Anouar, Luca Grumolato

Faculty, Staff and Students Publications

Non-small cell lung cancers (NSCLCs) treated with tyrosine kinase inhibitors (TKIs) of the epidermal growth factor receptor (EGFR) almost invariably relapse in the long term, due to the emergence of subpopulations of resistant cells. Through a DNA barcoding approach, we show that the clinically approved drug sorafenib specifically abolishes the selective advantage of EGFR-TKI-resistant cells, while preserving the response of EGFR-TKI-sensitive cells. Sorafenib is active against multiple mechanisms of resistance/tolerance to EGFR-TKIs and its effects depend on early inhibition of MAPK-interacting kinase (MKNK) activity and signal transducer and activator of transcription 3 (STAT3) phosphorylation, and later down-regulation of MCL1 and …

Threats In Adopting Financial Technologies: Unlocking The Role Of Technological Literacy, Shahbaz Tariq, Najabat Ali Dr., Muhammad Nauman Sadiq

Business Review

Financial technologies have been considered a transformative strategy in the contemporary world, paving the way for high-quality, time-convenient, and affordable financial services to individuals, businesses, and institutions. Despite the increasing security and financial risk, the perception of cyber threats remains unchanged. We conducted this study to analyze the perception of cyber threats, factors related to cybersecurity, and the behavior of customers adopting financial technologies through banking channels. To understand the behavior of individuals and business corporations, we developed a theoretical framework based on the Theory of Planned Behavior and the Technology Acceptance Model. A convenient sampling method was used, and …

Supporting Labor And Delivery Nurses Post-Trauma: Addressing Absenteeism And Retention In Practice, Catherine Crawford

Creating Healthy Work Environments (CHWE)

Labor and delivery (L&D) nurses frequently encounter traumatic workplace events that significantly impact their well-being, leading to increased absenteeism and intent to leave the profession (Kendall-Tackett & Beck, 2022; Uddin et al., 2022; Xie et al., 2021). This problem contributes to workforce instability and compromises patient care quality (Al Ismail et al., 2023). The purpose of this study is to examine the correlation between traumatic events, absenteeism, and intent to leave among labor and delivery nurses while discussing strategies to address these challenges.

I performed a mixed-methods study with a national sample of L&D nurses recruited from the Association of …

Enhancing Research Training Curricula Through The Ethical Integration Of Ai-Powered Tools: Opportunities And Challenges For Counselor Educators, Joshua C. Watson, Chris Leeth, Kevin Wong, Justen Schroeder

Journal of Counselor Preparation and Supervision

This article reviews existing training models used to teach research courses and facilitate researcher identity development in counselor education curricula and suggests how generative artificial intelligence (GenAI) can be incorporated into these courses as an instructional aid that improves researcher efficiency. Various GenAI tools used across stages of the research process are introduced with a discussion of their ethical implications and how they can be integrated into exiting lesson plans.

Mathematics And Mental Health: An Interdisciplinary Analysis Of Ai In Counselor Education, Jennifer M. Hightower, Catrina A. May

Journal of Counselor Preparation and Supervision

Although use of Artificial Intelligence (AI) in mental health care has become increasingly common, many professional counselors remain under informed about foundational components of AI. Fundamental issues associated with AI, including model bias and the Black Box Problem, must be considered as these tools become integrated into the counseling profession. This manuscript provides an interdisciplinary, theoretical analysis of AI use in counseling and counselor education grounded in foundational knowledge of AI and the American Counseling Association’s recommendations for the ethical integration of AI (Butler et al., 2023). The paper summarizes these recommendations, establishes accessible definitions of AI terms, explains the …

Counselor-In-Training Perceptions Of Artificial Intelligence: Implications For Counselor Education, Leo Gonzalez Jr., Deija Mccalla

Journal of Counselor Preparation and Supervision

This study examined the perceptions of counselors-in-training (CIT) on artificial intelligence (AI) in counseling practice and training. 31 CIT responded to three open-ended questions about the benefits, drawbacks, and overall attitudes of integrating AI into counseling practice and education. Thematic analysis was used to analyze the responses. The findings showed that CIT perceive AI as a clinical support tool, especially for tasks such as diagnosis and treatment planning. Additionally, CIT voiced concerns of potential overreliance on AI, ethical risks, confidentiality concerns, and the possible loss of human connection. Furthermore, although several CIT expressed cautious optimism regarding AI's use in counselor …

A Descriptive Comparison Of Results From Human And Ai-Driven Interpretive Phenomenological Analyses, Kahyen Shin, Melissa M. Luke

Journal of Counselor Preparation and Supervision

This study explores the concordance and discordance between human researchers and ChatGPT in conducting Interpretative Phenomenological Analysis (IPA) using an interview transcript with a refugee resettling in the United States. Findings revealed both alignment and discrepancies between ChatGPT and human researchers; while ChatGPT effectively identified themes and coding structures with interpretative depth and reflective engagement, it occasionally struggled to capture implicit meanings, particularly in narrative continuity and cultural-contextual analysis. These challenges were evident in its misinterpretation of past and present events, difficulty in recognizing nuanced associations, and tendency to adopt a deficit-based lens in certain analyses. Findings are discussed considering …

Integrating Artificial Intelligence In A University Counseling Clinic, Donna S. Sheperis, Shiri Sharvit

Journal of Counselor Preparation and Supervision

Artificial intelligence (AI) is increasingly used in mental health care, yet counseling students receive little training in digital tool integration. This program evaluation describes the use of an ambient AI platform in a university telemental health clinic to support clinical training. The AI system tracked interventions, themes, talk ratios, and symptom changes across 175 sessions by 13 trainees with 93 clients. Most frequent interventions included validation (97.6%), CBT skills (52.1%), and action planning (63.1%). Counselor talk time averaged 43% of the session, with themes such as relationships and school being predominant in client talk time.. By session 7, clients showed …

Artificial Intelligence In Counselor Education: Innovative Strategies For Teaching, Supervision, And Clinical Training, Shannon Shoemaker, Nikki Freeburg, Kevin Duquette

Journal of Counselor Preparation and Supervision

As artificial intelligence (AI) transforms mental health and education, counselor educators must prepare future practitioners to engage with these technologies ethically and effectively. This article presents a systematic framework for incorporating AI into counselor education through three key approaches: AI-generated content, AI analysis, and AI interactions. The framework addresses critical considerations including ethical implementation, prompt engineering, and cultural competence while maintaining alignment with professional standards. Drawing from current literature and ethical guidelines, we provide structured guidance for implementing AI across various content delivery styles, with emphasis on preserving clinical judgment and therapeutic relationships. Comprehensive appendices include implementation guides, assessment rubrics, …