Digital Commons Network^™

Encapsulation Of Disease-Causing And Commensal Mitis Group Non-Pneumococcal Streptococci, Daniel M Musher, Mathias Müsken, M John Hicks, Lesley Mcgee, Bernard Beall

Faculty, Staff and Students Publications

Background: Mitis group non-pneumococcal streptococci (MGNPS), specifically Streptococcus mitis, Streptococcus infantis and Streptococcus oralis, have recently been shown to cause pneumonia and/or bacteremia. These organisms often have capsular (cps) operons resembling those in pneumococci, and some express cps-generated polysaccharides that antigenically cross-react with pneumococcal capsular serotypes. But, to date, a series of MGNPS isolates has not been studied by electron microscopy (EM) for the presence of a capsule.

Methods: We studied 21 MGNPS; 11 were isolated from sputum and determined to have caused pneumonia, 3 were isolated from blood, and 7 were commensal isolates cultured …

Genome-Wide Insights Into The Genes And Pathways Shaping Human Foveal Development: Redefining The Genetic Landscape Of Foveal Hypoplasia, Callum Hunt, Ha-Jun Yoon, Alvin Lirio, Kayesha Coley, Jun Wang, Nick Shrine, Jianming Shao, Gail D E Maconachie, Zhanhan Tu, Jonathan H Zippin, Pirro G Hysi, Christopher J Hammond, Omar A Mahroo, Mariya Moosajee, Michel Michaelides, Andrew R Webster, Ala Moshiri, Rui Chen, Martin D Tobin, Chiara Batini, Mervyn G Thomas, Uk Biobank Eye And Vision Consortium

Faculty, Staff and Students Publications

Purpose: To define the genetic architecture of foveal morphology and explore its relevance to foveal hypoplasia (FH), a hallmark of developmental macular disorders.

Methods: We applied deep-learning algorithms to quantify foveal pit depth from central optical coherence tomography (OCT) B-scans in 61,269 UK Biobank participants. A genome-wide association study (GWAS) was conducted using REGENIE, adjusting for age, sex, height, and ancestry. Rare coding variants (frequency < 1%) were analyzed in an exome-wide rare-variant association study (RVAS). Candidate genes were prioritized using integrative mapping; pathway, cross-ancestry, and genetic-correlation analyses were exploratory.

Results: GWAS identified 126 sentinel variants, including 47 novel associations. Integrative mapping prioritized 129 putative causal genes, with 64 not previously implicated in foveal biology. Enriched pathways included retinoic acid metabolism (e.g., CYP26A1), photoreceptor differentiation …

Surgery Versus Surveillance: A Quality-Of-Life Analysis Of Patients With Moderately Dilated Aortic Root Or Ascending Aorta, Ming Hao Guo, Puja Kachroo, Et Al.

2020-Current year OA Pubs

OBJECTIVES: The impact of diagnosis and management of ascending thoracic aortic aneurysm (ATAA) on patients' quality of life (QoL) is not well characterized. This study aims to compare QoL with surgery versus surveillance in patients with moderate ATAAs.

METHODS: Treatment In Thoracic Aortic aNeurysm: Surgery versus Surveillance is a multicentre randomized trial for patients with ATAA between 5.0 and 5.4 cm and includes a registry of patients who underwent either surgery or surveillance. From May 2019 to December 2022, 157 patients from 15 centres were enrolled in the surveillance (n = 105) or surgery (n = 52) registry and completed …

The Quality Of Life And Marital Adjustment Among Omani Women With Infertility: A Prospective Cross-Sectional Study, Ruhina Aimaq, Moon F. Chan, Maha Alkhaduri, Jokha Alsabti, Hana Alsumri

Sultan Qaboos University Medical Journal

Objectives: Female infertility causes considerable emotional distress for affected women, negatively influencing their quality of life (QOL) and marital stability. This study aimed to identify factors influencing QOL and marital distress among Omani women attending a fertility clinic. Methods: This cross-sectional study included Omani women seeking infertility treatment at Sultan Qaboos University Hospital, Muscat, Oman, from November 2022 to February 2023 and assessed QOL using the WHOQOL-BREF and marital adjustment using the Arabic Revised-Dyadic Adjustment Scale. Results: A total of 150 women were included in this study. The mean World Health Organization QOL-Brief Version score was 69.40 …

Neoadjuvant Bms-813160, Nivolumab, Gemcitabine, And Nab-Paclitaxel For Patients With Pancreatic Cancer, Patrick M Grierson, Crystal Wolf, Rama Suresh, Andrea Wang-Gillam, Benjamin R Tan, Lee Ratner, Peter Oppelt, Olivia Aranha, Ashley Frith, Katrina S Pedersen, Jennifer Spann, Nicholas Boice, Amberly Brown, John M Baer, Emily G Butka, Faiz Ahmad, Yifei Xu, Jingxia Liu, David G Denardo, Kian-Huat Lim

2020-Current year OA Pubs

PURPOSE: Targeting tumor-associated macrophages through C-C chemokine receptor type 2 (CCR) in pancreatic ductal adenocarcinoma (PDAC) improves the efficacy of chemotherapy and restores T-cell immunity in preclinical models.

PATIENTS AND METHODS: We conducted a phase I/II single-institution study (NCT03496662) combining chemotherapy gemcitabine and nab-paclitaxel (GnP), CCR2/5 inhibitor BMS-813160, and nivolumab for four 28-day cycles for patients with borderline resectable (BR) or locally advanced (LA) PDAC. The recommended phase II dose of BMS-813160 was established in the 3 + 3 design. Primary endpoints were safety and objective response rate (ORR). Secondary endpoints included resection rate, median progression-free survival, and median overall …

Risk Of Cardiovascular Events During Delivery Hospitalization Among Pregnant Patients With Mental Health Conditions, Kavya Parekh, R J Waken, Khavya Avula, Katelin B Nickel, Kathryn J Lindley, Cynthia Rogers, Karen E Joynt Maddox

2020-Current year OA Pubs

BACKGROUND: Cardiovascular disease remains the leading cause of maternal mortality. Mental health disorders are risk factors for cardiovascular disease in nonpregnant populations, but their association with delivery outcomes is unknown.

METHODS: This cross-sectional study used delivery hospitalizations from the 2021 National Inpatient Sample. We used generalized estimating equations to fit quasi-Poisson regression models for cardiovascular severe maternal morbidity and mortality (SMM) events as defined by the Centers for Disease Control and Prevention, and non-SMM cardiovascular conditions or complications as defined by the Alliance for Innovation on Maternal Health. Incidence rate ratios were calculated for depression, anxiety, psychosis, bipolar, obsessive-compulsive disorder, …

Sickle Cell Disease And Dental Care Access Among Medicaid-Enrolled Youths, Ashley Kranz, Hannah K Peng, Allison A King, Sarah J Clark, Melissa A Plegue, Sarah L Reeves

2020-Current year OA Pubs

No abstract provided.

Targeting The Il-36 Receptor With Spesolimab Mitigates Residual Inflammation And Prevents Generalized Pustular Psoriasis Flares, James G. Krueger, Milan J. Anadkat, Et Al.

2020-Current year OA Pubs

People with generalized pustular psoriasis experience underlying skin inflammation, even in the absence of flares. Spesolimab treatment helps control the inflammation and prevent future flares.

Revealing Hyperactivated Ifn-Γ Pathways In Perianal Fistulizing Crohn's Disease Using Single-Cell And Spatial Multi-Omics, Siyan Cao, Khai M. Nguyen, Kaiming Ma, Tingyi Tan, Xin Yao, Ta-Chiang Liu, Malek Ayoub, Jalpa Devi, Sami Samaan, Yizhou Liu, Radhika Smith, Matthew L. Silviera, Steven R. Hunt, Paul E. Wise, Matthew G. Mutch, Sean C. Glasgow, William C. Chapman, Michelle L. Cowan, Matthew A. Ciorba, Marco Colonna, Parakkal Deepak, Sparc Ibd Investigators

2020-Current year OA Pubs

Up to 40% patients with Crohn's disease suffer from perianal disease, a debilitating complication with unclear etiology. This study identified unique pathophysiology which may help develop novel therapies.

Age-Dependent Brain Responses To Mechanical Stress Determine Resilience In A Chronic Lymphatic Drainage Impairment Model, Zachary Gursky, Zohaib Nisar Khan, Sunil Koundal, Ankita Bhardwaj, Joaquin Caceres Melgarejo, Kaiming Xu, Xinan Chen, Hung-Mo Lin, Xianfeng Gu, Hedok Lee, Jonathan Kipnis, Yoav Dori, Allen Tannenbaum, Laura Santambrogio, Helene Benveniste

2020-Current year OA Pubs

The outflow of 'dirty' brain fluids from the glymphatic system drains via the meningeal lymphatic vessels to the lymph nodes in the neck, primarily the deep cervical lymph nodes (dcLN). However, it is unclear whether dcLN drainage is essential for normal cerebral homeostasis. Using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and computational fluid dynamics, we studied the impact of long-term mechanical stress from compromised dcLN drainage on brain solute and fluid outflow in anesthetized rats. We found that in young, but not middle-aged, rats, impairment of dcLN drainage was linked to moderately increased intracranial pressure and the emergence of extracranial …

Childhood Loneliness And Cognitive Decline And Dementia Risk In Middle-Aged And Older Adults, Jinqi Wang, Danyang Jiao, Xiaoyu Zhao, Yixing Tian, Haibin Li, Xia Li, Chen Sheng, Lixin Tao, Hui Chen, Zhiyuan Wu, Xiuhua Guo

Research outputs 2022 to 2026

Importance: Adult loneliness has been linked to cognitive decline and dementia risk, but the long-term implications of childhood loneliness remain underexplored. Objectives: To investigate whether childhood loneliness is associated with cognitive decline and dementia risk and whether adult loneliness mediates or modifies these associations. Design, Setting, and Participants: This cohort study used data from the China Health and Retirement Longitudinal Study, a nationally representative cohort study conducted between June 1, 2011, and December 31, 2018, with a maximum follow-up of 7 years. Data analyses were performed from October 1, 2024, to January 15, 2025. Exposure: Childhood loneliness was defined as …

Mepolizumab Alters Gene Regulatory Networks Of Nasal Airway Type-2 And Epithelial Inflammation In Urban Children With Asthma, Courtney L Gaberino, Michelle A Gill, Jeffrey Stokes, Et Al.

2020-Current year OA Pubs

Mepolizumab (anti-IL5 therapy) reduces asthma exacerbations in urban children with exacerbation-prone eosinophilic asthma. We previously utilized nasal transcriptomics to identify inflammatory pathways (gene co-expression modules) associated with asthma exacerbations despite this therapy. In this study, we applied differential gene correlation analysis on these targeted gene co-expression modules to gain better insight into the treatment effects on correlation structure within gene networks. Mepolizumab treatment resulted in loss of correlation amongst eosinophil-specific genes but conservation and even strengthening of correlation amongst mast cell-specific genes, T2 cytokines, and airway epithelial inflammatory genes. Notably, mepolizumab induced significant gain in correlation of genes associated with …

Healing The Sacred: The Fight To Restore Onondaga Lake And Honor Indigenous Land, Adam Dj Brett, Betty Lyons Hill

International Journal on Responsibility

The Onondaga Nation is petitioning the Organization of American States (OAS) for land rights to Onondaga Lake, a notoriously polluted body of water in Central New York State. The Onondaga Nation is one of six nations of the Haudenosaunee Confederacy (Iroquois), and Onondaga Lake is the sacred site where Gayanashagowa, the Great Law of Peace, was established. As Keepers of the Central Fire, the Onondaga Nation bears the responsibility of maintaining unity and peace within the Haudenosaunee Confederacy. This article examines the history of the lake, its significance to the Haudenosaunee Confederacy, and the consequences of its desecration through …

Fun! Friends! Famous People! Why Fans Attend Anime Conventions, Billy Tringali, Maria Alberto, Jeremiah Martinez

Proceedings from the Document Academy

In 2021 during the global Covid-19 lockdowns, Billy and Maria ran an IRB-exempted online survey, looking to hear from fans who attend anime conventions. Conventions had been shut down as non-essential services that drew large crowds, and we hoped to capture a screenshot of this moment, to better learn from it in the future. And the resulting data collection went quite well – we were able to partner with a major anime organization to share the survey, and our 1000+ respondents had a lot to say about the conventions they were missing during lockdowns.

Ultimately, we found a significant emphasis …

How Subversive Is Shipping Really? An Analysis Of Heteronormative Elements In Same-Sex Relationships Focused On German-Language Anime And Manga Fan Fiction, Saskia Dreßler

Proceedings from the Document Academy

This study investigates whether German-language fan fictions featuring lesbian and gay characters within the anime and manga domain can be regarded as genuinely queer. It situates these fan works within the specific traditions and practices of German fandom. Employing qualitative content analysis, the research examines two prominent fandoms, Naruto and Sailor Moon, focusing on the presence of heteronormative narrative patterns in fan fiction with queer protagonists. The study analyzes which aspects of the original media are adapted and how these adaptations shape the portrayal of queer identities. Furthermore, fan comments are examined to assess the extent to which readers …

Homeschooling: An Alternative Learning Modality For K-12 Students In The Post-Pandemic Era, Alyza Eve N. Bayudan, Maia Katerina C. Bautista, Sapi Kabbigat Yawi B. Bimuyag, Enrico Angelo Noel R. Delenela, Charles Josef L. Kumalao, Jonathan O. Langaoan, Alfonso B. Astudillo Iii

DLSU Senior High School Research Congress

The rise of homeschooling amidst the COVID-19 pandemic, particularly in the Philippines, prompted this study to explore its viability as an alternative to traditional schooling. Concerns over health and dissatisfaction with existing educational systems drove parents to opt for homeschooling despite challenges such as limited resources and socialization opportunities. Utilizing interviews, online surveys, and onsite observations, this research aimed to dispel stigmas and misconceptions surrounding homeschooling while highlighting its diverse approaches and philosophies. Research objectives encompass evaluating reasons for choosing homeschooling, understanding its impact on children's educational, physical, mental, social, and emotional needs, and assessing overall satisfaction with the homeschooling …

Psychological Immunity Among Jordanian University Students During The Outbreak Of The Coronavirus Pandemic, Dalal Al-Samadi

Jordan Journal of Applied Science-Humanities Series

The purpose of the study was to investigate the level of psychological immunity and to determine whether there are statistically significant differences at the significance level (α = 0.05) in psychological immunity based on variables such as gender, academic specialization, and age among students of Jordanian universities during the outbreak of the coronavirus pandemic. To achieve the study's objectives, the researcher developed a scale to measure psychological immunity. The study sample consisted of 768 male and female students, selected by the convenience sampling method. The findings indicated a high level of psychological immunity among the students. Additionally, the results showed …

The Relationship Between The Level Of Optimism And The Performance Of Volleyball Players In The Premier League In The West Bank, Mahmoud Al-Atrash, Mosab Rashed

Jordan Journal of Applied Science-Humanities Series

The current study aimed to identify the relationship between the level of optimism and the performance of volleyball players in the Premier League in the West Bank. The researchers adopted a descriptive approach to suit the nature of the study. The sample consisted of 45 players, representing 42% of the original population. A measure of optimism, designed by the researchers after reviewing relevant educational literature and previous studies, was administered to the participants. To analyze the data, the researchers used One-Way ANOVA and T-tests. Among the most important findings was that the level of optimism among high-performing volleyball players in …

Salivary Matrix Metalloproteinase-7, Human Beta-Defensin 1, And Mucin-4 As Potential Diagnostic Biomarkers In Periodontal Disease: A Review, Haider Mohammed Shaloom, Omar Husham Ali

Maaen Journal for Medical Sciences

Periodontal diseases are a group of chronic, immune-mediated inflammatory conditions affecting the periodontium, the supportive structures of the teeth. With severe forms affecting nearly 20% of the worldwide adult population, these diseases represent a significant global health challenge. Their impact extends beyond the oral cavity, as periodontitis is a recognized risk factor for systemic conditions like cardiovascular disease and diabetes mellitus. Characterized by the progressive destruction of tooth-supporting tissues, early diagnosis is crucial to prevent tooth loss. However, conventional diagnostic methods primarily quantify historical tissue damage rather than indicating current disease activity or predicting future progression. To overcome these limitations, …

Thermal Spreader Materials On Flexible Polymer Substrates

Defensive Publications Series

The present disclosure is generally directed to techniques and materials for thermal spreader materials, such as for use in products and applications with flexible polymer-based substrates

The Role Of Administration In Enhancing Community Partnership In Arab Schools In Beersheba Region, Ayman Abu Hajaj, Nouwar Al-Hamad

Jordan Journal of Applied Science-Humanities Series

The purpose of this study was to reveal the role of administration in enhancing community partnerships in Arab schools in Beersheba region from the school principals’ point of view. A descriptive survey approach was used to target the principals. The study sample intentionally consisted of all school principals in the region, totaling 100 principals from both genders. To collect data, a questionnaire consisting of 33 items was developed. Three independent variables were further investigated, namely: the school location, the principal's gender, and the principal's years of experience in the post. The results showed that the overall principals' estimate of the …

Logical Intelligence In Light Of The Prophetic Sunnah, Asma Bani Amer

Jordan Journal of Applied Science-Humanities Series

This study focuses on an aspect related to the text of the Hadith, known as the subject-related Hadith. Specifically, it examines the Hadiths concerning what is called motor intelligence, in light of the Prophetic Sunnah. Modern education has paid attention to what is called multiple intelligences, including: bodily-kinesthetic intelligence, which is one of the forms of intelligence that emphasizes physical skills and athletic abilities. This aspect holds great importance in the Sunnah; therefore, the study aims to clarify the concept of motor intelligence, the extent of Islam’s concern with this aspect, and its most prominent expressions in light of the …

Evaluation Of Mobility And Functional Balance In Elderly Individuals With Type 2 Diabetes Based On Selected Kinematic Variables, Osama Abdel Fattah, Khaled Atiyat, Thamer Al-Manaseer

Jordan Journal of Applied Science-Humanities Series

This study aims to evaluate the kinematic indicators in the Timed Up and Go (TUG) test and the level of functional balance in the study sample according to the Berg Balance Scale. Additionally, it examines the relationship between BMI and the duration of diabetes with the values of kinematic indicators in the study sample in the TUG test and the level of functional balance on the Berg Balance Scale. Furthermore, it explores the relationship between the values of the kinematic indicators in the TUG test and the level of functional balance. To achieve this, the researchers employed a descriptive approach …

The Effectiveness Of Counseling Program Based On Adlerian Therapy To Improve Family Relations Among Battered Syrian Refugee Women, Rasha Husban, Fawwaz Ayoub Momani

Jordan Journal of Applied Science-Humanities Series

This study aimed to identify the effectiveness of Adlerian treatment in improving family relations among battered Syrian refugee women. The study sample consisted of (30) Syrian refugee women from the city of Irbid, Jordan. The study sample was random. assigned to two groups: an experimental (15 women) and a control group (15 woman to achieve the study objectives, a family relations scale Manual (was used for the two groups, and a counseling program based on Adlerian therapy, developed by the researchers, consists of (14) sessions was applied to the experimental group. The results showed that the program was effective in …

What Next? A Challenging Case Of Refractory Hypertension With End-Organ Dysfunction In A 33-Year-Old Male, Rezane Miftari Md, Shaun Abid, Anton Stolear, Irma Fotjhadi

Posters

We present a challenging case of a 33-year-old male with history of longstanding hypertension since high school, which progressed to RH complicated by severe left ventricular hypertrophy and hypertensive nephrosclerosis.

Library Lens September 2025, Southern Adventist University

Library Lens

The September 2025 edition of Library Lens includes information on digital newspaper access, information literacy modules, Libby account updates, and Hispanic Heritage Month.

Volume 11 Issue 12 (Sept 1912)

The Soul Winner

No abstract provided.

Toward A Unified Neuroaesthetic Framework For Art-Based Interventions In Substance Use Recovery - A Review, Piper Hutson, James Hutson

Faculty Scholarship

Art-based interventions have gained increasing recognition as complementary strategies for substance use disorder (SUD) recovery and prevention, yet the field remains fragmented across clinical art therapy, community-based programs, and expressive digital practices. This article advances a unified neuroaesthetic framework that integrates sensory regulation, narrative integration, and interpersonal synchronization as the core mechanisms of healing. Drawing on recent U.S.-based empirical studies (post-2020), the paper synthesizes evidence from multiple modalities, including visual arts, music therapy, dance/movement practices, and digital storytelling, each demonstrating measurable effects on craving reduction, stress regulation, identity reconstruction, and social connection. Neuroscientific insights are central: findings highlight how creative …

The Information Edge - Library Newsletter - September 2025, Sarah Burns-Feyl, Jennifer Rosenstein

University Library Newsletter

No abstract provided.

Learning In Virtual Environments With Varying Levels Of Sensory Information, Maryam Derayati Far

Psychology Theses and Dissertations

The sensory environment plays a critical role in shaping learners’ attention, engagement, and retention. This thesis investigates how varying levels of sensory input in virtual reality (VR) classrooms influence learning for two age groups—children and young adults—and explores how individual differences in sensory processing moderate these effects. Using immersive VR technology to simulate classroom settings, two experimental studies were conducted. Study One involved 60 children aged 6–15 years, recruited primarily through a university-run summer camp. Study Two included 57 undergraduate students aged 18–36 years, recruited through a research participation pool. In both studies, participants were randomly assigned to either a …