Digital Commons Network^™

Impact Of Metformin On Brca1 Expression And Breast Cancer Risk In T2dm Patients, Hanan Hamed Hassan, Perry Habeb Saif Ullah

Baghdad Science Journal

This study aims at detecting the level of BRCA1 protein as a marker of breast cancer in Iraqi women previously suffering from type 2 diabetes mellitus. The study includes: 80 participants they were divided into three subgroups based on drugs strategy and duration of disease, with ages (40–70) years. Blood samples were collected from Ibn AL-Bitar Hospital in Baghdad / Iraq between the period from November 2022 to February 2023. Some biochemical parameters were measured for all study groups, which include: -Fasting blood sugar (FBS) and Lipid profile, which were measured by enzymatic oxidation method. Using an enzymatic process, Insulin …

Staff Education To Increase Knowledge About The Workflow Process, Mwikali Mutia-Lamin

Walden Dissertations and Doctoral Studies

This Doctor of Nursing Practice (DNP) project was conducted to address staff’s lack of knowledge about the workflow process in an outpatient mental health setting. Evidence has shown that staff’s lack of knowledge about workflow processes creates ineffective communication and collaboration in care as well as reduces patient outreach. The practice-focused question was focused on determining whether training staff in an outpatient mental health setting about the organization’s workflow process increased their knowledge on how to use the workflow process in an effort to improve patient care and care outcomes. Thirteen of the 20 staff members participated in this educational …

First-Generation Black And Latinx Students And Their Perceived Level Of Postsecondary Education Preparedness, Shawanna Burton

Walden Dissertations and Doctoral Studies

First-generation Black and Latinx students report challenges of belonging and preparation in the transition to college. Limited research on these experiences hinders counselors’ support for these students. The purpose of this hermeneutic phenomenological study was to explore first-generation Black and Latinx college students’ meaning of their high school experiences. A hermeneutic phenomenology conceptual framework was used to explore the lived experiences of first-generation Black and Latinx college students, focusing on how guidance from high school counselors influenced their sense of belonging, persistence, and degree attainment in postsecondary education. Data were collected from nine participants through semistructured interviews and analyzed using …

Postpartum Conversion Type 2 Diabetes In African American Women With Gestational Diabetes, Guerino Tondreau

Walden Dissertations and Doctoral Studies

Type 2 diabetes mellitus (T2DM) remains a significant public health concern in the United States, with non-Hispanic Black women bearing a disproportionately high burden of the disease. Although this group has a lower overall prevalence of gestational diabetes mellitus (GDM), those who develop GDM face an increased risk of progressing to T2DM. The purpose of this quantitative, correlational study was to explore the relationship between GDM, physical activity, weight status, and T2DM development among non-Hispanic Black women. Secondary data from the National Health and Nutrition Examination Survey, collected from 2017 through March 2020, were analyzed. The health belief model served …

Service Learning And Association To Social Responsibility And The Process Of Cultural Competence In Nursing Practice, Helene Kay Hegge

Walden Dissertations and Doctoral Studies

Service Learning and Association to Social Responsibility and the Process of Cultural Competence in Nursing Practice by Helene Hegge MSN, Walden University, 2011 BSN, Mount Marty University, 1986 Dissertation Submitted in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy Nursing Walden University August 2025 Cultural competence and social responsibility are essential qualities of baccalaureate-prepared nurses. Cultural competence and social responsibility can occur in nursing students following their service learning (SL) experience and remain to influence practice as a professional nurse. The purpose of this basic qualitative study using 18 individual interviews of nurses who participated in …

Interplay Between Admission And Early Postpartum Blood Pressure And Risk Of Postpartum Readmission For Hypertension, Juan C. Naranjo, J. Hunter Collins, Elizabeth F. Sutton

School of Medicine Faculty Publications

No abstract provided.

Brief Of Amici Curiae Center For Civil Rights And Critical Justice And Fred T. Korematsu Center For Law And Equity In Support Of Petitioners, Jessica Levin, Melissa Lee, Ronald A. Peterson Law Clinic, Fred T. Korematsu Center For Law And Equality

Center for Civil Rights and Critical Justice Advocacy

No abstract provided.

Creating A Classroom Environment For Prekindergarten Students To Develop Social-Emotional Competencies And Transition Out Of The Step Program., Ayeshah N. Major

Theses and Dissertations

This mixed-methods study examined how the integration of Conscious Discipline and SEL-focused children’s literature can support the development of social-emotional competency in prekindergarten students. The problem of practice is that some children enter school without the foundational social-emotional skills necessary for successful learning and positive peer interactions. The purpose of this study is to identify strategies that support social-emotional growth and create an environment that aids STEP students in transitioning to a traditional prekindergarten classroom. Data was collected using parent questionnaires, student assessments, classroom observations, student interviews, and student drawings. The findings revealed that children’s literature provided accessible and meaningful …

Spartan Daily, September 16, 2025, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2025

Volume 165, Issue 10

Retraction Of Activation Of Rac1 By Src-Dependent Phosphorylation Of Dock180y1811 Mediates Pdgfrα-Stimulated Glioma Tumorigenesis In Mice And Humans, Haizhong Feng, Bo Hu, Kun-Wei Liu, Yanxin Li, Xinghua Lu, Tao Cheng, Jia-Jean Yiin, Songjian Lu, Susan Keezer, Tim Fenton, Frank B Furnari, Ronald L Hamilton, Kristiina Vuori, Jann N Sarkaria, Motoo Nagane, Ryo Nishikawa, Webster K Cavenee, Shi-Yuan Cheng

Faculty, Staff and Student Publications

No abstract provided.

Elevated Nr2f1 Underlies The Persistence Of Invasive Disease After Treatment Of Braf-Mutant Melanoma, Manoela Tiago, Timothy J Purwin, Casey D Stefanski, Renaira Oliveira Da Silva, Mitchell E Fane, Yash Chhabra, Jelan I Haj, Jessica Lf Teh, Rama Kadamb, Weijia Cai, Sheera R Rosenbaum, Vivian Chua, Nir Hacohen, Michael A Davies, Jessie Villanueva, Inna Chervoneva, Ashani T Weeraratna, Dan A Erkes, Claudia Capparelli, Julio A Aguirre-Ghiso, Andrew E Aplin

Faculty, Staff and Student Publications

Despite the success of targeted inhibitors in cutaneous melanoma, therapeutic responses are limited by the aged tumor microenvironment and drug-tolerant residual cells. Given the similarities between drug tolerance and cellular dormancy, we studied the dormancy marker, nuclear receptor subfamily 2 group F member 1 (NR2F1), in response to BRAF-V600E inhibitors (BRAFi) plus MEK inhibitors (MEKi) in BRAF-mutant melanoma models. Transcriptomic analysis of melanoma patient samples treated with BRAFi + MEKi showed increased NR2F1. NR2F1 was highly expressed in the drug-tolerant invasive cell state of minimal residual disease in patient-derived and mouse-derived xenografts on BRAFi + MEKi. NR2F1 over-expression was sufficient …

33 Unresolved Questions In Nanoscience And Nanotechnology, Chad A Mirkin, Sarah Hurst Petrosko, Natalie Artzi, Koray Aydin, Austin Biaggne, C Jeffrey Brinker, Katherine E Bujold, Y Charles Cao, Rachel R Chan, Chaojian Chen, Peng-Cheng Chen, Xiaodong Chen, Olivier J G L Chevalier, Chung Hang Jonathan Choi, Richard M Crooks, Vinayak P Dravid, Jingshan S Du, Sasha B Ebrahimi, Hongyou Fan, Omar K Farha, C Adrian Figg, Tanner D Fink, Connor M Forsyth, Harald Fuchs, Franz M Geiger, Nathan C Gianneschi, Kyle J Gibson, David S Ginger, Sishi Guo, Justin S Hanes, Liangliang Hao, Jin Huang, Bryan M Hunter, Fengwei Huo, Jeongmin Hwang, Rongchao Jin, Shana O Kelley, Thomas J Kempa, Youngeun Kim, Sergej Kudruk, Sneha Kumari, Kaitlin M Landy, Ki-Bum Lee, Noel J Leon, Jun Li, Yuanwei Li, Zhiwei Li, Bin Liu, Guoliang Liu, Xiaogang Liu, Luis M Liz-Marzán, Jochen H Lorch, Taokun Luo, Robert J Macfarlane, Jill E Millstone, Milan Mrksich, Catherine J Murphy, Rajesh R Naik, Andre E Nel, Christopher Oetheimer, Jenny K Hedlund Orbeck, So-Jung Park, Benjamin E Partridge, Nicholas A Peppas, Michelle L Personick, Arindam Raj, Namrata Ramani, Michael B Ross, Stacey Barnaby Ross, Edward H Sargent, Tanushri Sengupta, George C Schatz, Dwight S Seferos, Tamar Seideman, Soyoung Eileen Seo, Bo Shen, Wooyoung Shim, Donghoon Shin, Ulrich Simon, Andrew J Sinegra, Peter T Smith, Alexander M Spokoyny, Peter J Stang, Alexander H Stegh, J Fraser Stoddart, Dayne F Swearer, Weihong Tan, Michelle H Teplensky, C Shad Thaxton, David R Walt, Mary X Wang, Zhe Wang, Wei David Wei, Paul S Weiss, Peter H Winegar, Younan Xia, Yi Xie, Xiaoyang Xu, Peidong Yang, Yiming Yang, Zihao Ye, Kuk Ro Yoon, Cuizheng Zhang, Hua Zhang, Ke Zhang, Liangfang Zhang, Xiaoyu Zhang, Ye Zhang, Zijian Zheng, Wenjie Zhou, Shengshuang Zhu, Wei Zhu

Faculty, Staff and Student Publications

Significant advances in science and engineering often emerge at the intersections of disciplines. Nanoscience and nanotechnology are inherently interdisciplinary, uniting researchers from chemistry, physics, biology, medicine, materials science, and engineering. This convergence has fostered novel ways of thinking and enabled the development of materials, tools, and technologies that have transformed both basic and applied research, as well as how we address critical societal challenges. In this Nano Focus, we pose and explore 33 questions whose answers could profoundly impact fields such as energy, electronics, the environment, optics, and medicine. These questions highlight the need for deeper foundational understanding, improved tools …

A Single-Dose Long-Lasting Live-Attenuated Chimeric Vaccine Candidate Against The Emerging Tick-Borne Kyasanur Forest Disease, Young-Min Lee

Funded Research Records

No abstract provided.

Digitized Endocasts And Brains: A Perspective On Measurements And Historical Analyses Of The Evolution Of 172 Fossil And Extant Amniote Specimens, Harry J Jerison, Catherine M Early, Andrew A Farke, Ashley C Morhardt

2020-Current year OA Pubs

This perspective paper is intended to stimulate future research and discussion of brain evolution in amniotes by sharing 172 digitized endocasts of extinct and extant species spanning 60 million years. Using 3D digital surface scans of physical (

Investigating The Effects Of Cystatin D On Osteoporosis In Iraqi Patients, Zahraa Salim Hassan, Layla Othman Farhan

Baghdad Science Journal

The common systemic skeletal disorder known as osteoporosis (OP) is characterized by low bone mass and microarchitectural deterioration of bone tissue, which makes bones brittle and prone to breaking. Because of Cystatin D (CST5) peptide potential to regulate a significant class of proteolytic enzymes that play a crucial part in pathophysiological processes, cystatins have drawn a lot of attention in the past ten years, as well as their real efficacy in preventing the growth of bacteria and viruses in vivo. This study evaluated the serum cystatin D (CST5) diagnostic accuracy in osteoporosis and osteopenia patients. One hundred twenty participants were …

Design, Synthesis And Antibacterial Evaluation Of Some New Pyrrolidine Derivatives Based Pyrazole Moiety Via Vilsmeier-Haack Reaction, Sabah Salim Al-Dulaimi, Muna Sameer Al-Rawi

Baghdad Science Journal

The following work involved synthesizing a new series of substituted Pyrrolidine/4H-Pyrazole-4-carbaldehyde derivatives [IV]_a-e derived from captopril known as an angiotensin converting enzyme inhibitor drug, using the Vilsmeier-Haack reaction. There were some steps involved for synthesizing new hydrazone compounds [III]_a-e via refluxing equal mole of captopril hydrazide [II] with different substituted aromatic ketone (acetophenone, 4-hydroxyacetophenone, 4-aminoacetophenone, 4-nitroacetophenone, and 4-bromoacetophenone) in benzene via condensation reaction. The newly substituted 4H-pyrazole-4-carbaldehyde derivatives [IV]_a-e are obtained via a cyclization reaction of substitute hydrazones [III]_a-e heating with POCl₃/DMF, under Vilsmeier–Haack reaction. The prepared pyrrolidine derivatives-based pyrazole …

Preparation Of Graphene Oxide From Waste Pencils And Loading It On The Surface Of Melamine-Formaldehyde/Rgo Composite For Hydrocarbons Removal, Afraa Mamoon Ahmed, Mohammed Qasim Mohammed, Hayder Baqer Abdullah

Baghdad Science Journal

With the increasing technological development, the problem of hydrocarbon pollution has become one of the urgent problems of our current era. Many techniques have been proposed and applied to address this phenomenon, including the use of polymer-based nanocomposites. This study involved the preparation of a few wrinkled layers of graphene oxide from waste pencils (wp-GO) as proved by the High-resolution transmission electron microscopy HRTEM image. Besides, magnetic iron oxide nanoparticles were synthesized and showed superparamagnetic properties due to the magnetic properties of 40 emu/g saturation magnetization and close to zero coercivity, the structure is mostly spherical particles with a diameter …

Butte Priority Soils Operable Unit Clark Tailings Consolidated Waste Management Area Site Investigation Quality Assurance Project Plan (Qapp) Revision 0, Woodard & Curran

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Tokenization And Interconnectedness: A Numerical Exploration, Alessandro Gioffré, Gabriele Camera

ESI Working Papers

Tokenization of assets has multiple implications for the operation of financial markets, among which are mitigating trade frictions and improving the interconnectedness of financial firms. This feature—if not properly managed—can propagate shocks more widely as compared to a traditional system. We study this double-edged aspect of tokenization using a matching model that makes explicit how firms are exposed to counterparty risk. We propose a way to manage this increased risk, through Financial Transactions Limiters, which exploit the technical advantages of tokenization in monitoring financial transactions of individual firms. We numerically analyze the possible social welfare consequences of tokenization, in …

Artificial Intelligence In Head And Neck Cancer: Towards Precision Medicine., Jacob Hagen, Logan Hornung, William Barham, Supratik Mukhopadhyay, Ada Bess, Kevin Contrera, Kevin Contrera, Devraj Basu, Vlad Sandulache, Guillaume Spielmann, Sagar Kansara

School of Medicine Faculty Publications

Simple Summary: This review was conducted to highlight current and potential applications of artificial intelligence (AI) in the care of patients with head and neck cancer, the barriers to its clinical implementation, and the relative scarcity of research in this field. While AI has demonstrated success in other areas of oncology, its role in head and neck cancer remains limited, with progress slowed by technical, ethical, and logistical challenges. Nevertheless, integrating AI with multiomics approaches presents a promising opportunity to advance precision medicine in this patient population. The findings presented in this manuscript may encourage further multi-institutional studies aimed at …

Rutger Bregman’S Vision: Moral Ambition Without Imagination, Vladimir Snurenco

University Faculty Publications and Creative Works

This review critiques Rutger Bregman’s top-down blueprint—higher taxes, new laws, and big-ticket nonprofits—as a centralized moralism that sidelines the institutions that actually nurture prosperity and dignity: family, church, enterprise, and local associations. I contrast Bregman’s Robin-Hood rhetoric (and his School for Moral Ambition) with a subsidiarity-driven vision rooted in Tocqueville, Kuyper, and Nisbet, and with Michael Pakaluk’s call for vocation within business. Drawing on research by Owen Zidar (the “stealthy wealthy”) and The Millionaire Next Door, I argue Bregman caricatures the rich and misunderstands how wealth is created.

I also question his nonprofit model: celebrating outputs (money raised, nets distributed) …

Sorting Nexin 3 Promotes Ischemic Retinopathy Through Rip1- And Rip3-Mediated Myeloid Cell Necroptosis And Mitochondrial Fission, Jiaojiao Wang, Chunhong Zhou, Kai Zhuang, Jiami Zou, Wanlu Qiu, Mei Jin, Weile Ye, Pinglian Yang, Zhihua Zheng, Qing Zhou, Zunnan Huang, Yuanxiang Wang, Peiqing Liu, Jing Lu, Yuqing Huo, Zhiping Liu

Faculty, Staff and Students Publications

Proliferative retinopathy is a leading cause of irreversible blindness in humans; however, the molecular mechanisms behind the immune cell–mediated retinal angiogenesis remain poorly elucidated. Here, using single-cell RNA sequencing in an oxygen-induced retinopathy (OIR) model, we identified an enrichment of sorting nexin (SNX)-related pathways, with SNX3, a member of the SNX family that is involved in endosomal sorting and trafficking, being significantly upregulated in the myeloid cell subpopulations of OIR retinas. Immunostaining showed that SNX3 expression is markedly increased in the retinal microglia/macrophages of mice with OIR, which is mainly located within and around the neovascular tufts. Myeloid cell-specific deficiency …

The Presence Of Family Members During Brainstem Testing: An Ethical Dilemma, Natalie L. Mcevoy, Pierce Geoghegan, Sophia Downey, Jos Latour, Alan Gaffney, James O'Rourke, Gerard F. Curley

School of Nursing and Midwifery

The purpose of this article was to discuss the ethical issues relevant to inviting family members to witness brainstem testing in the intensive care unit (ICU). To highlight these issues, we begin by discussing a hypothetical clinical case of a patient admitted to the ICU following an out-of-hospital cardiac arrest. A brief review of the literature on current practice will be presented, followed by a balanced discussion on the practice of permitting relatives to witness brainstem testing under the ethical principles of beneficence, non-maleficence, autonomy and justice. Finally, we will present a discussion on international recommendations surrounding this practice as …

Amino Acids And Cart Distinguish A-Β+ Ketosis-Prone Diabetes From Type 1 And Type 2 Diabetes During Hyperglycemic Crises, Farook Jahoor, Jean W Hsu, Kelly R Keene, W Frank Peacock, Xiaofang Huang, Danielle Guffey, Jinyoung Byun, Rasmus Bennet, Ake Lernmark, Mustafa Tosur, Ashok Balasubramanyam

Children’s Nutrition Research Center Staff Publications

Context: When clinically stable, patients with A-β+ ketosis-prone diabetes (KPD) manifest unique markers of amino acid metabolism. Biomarkers differentiating KPD from type 1 (T1D) and type 2 diabetes (T2D) during hyperglycemic crises would accelerate diagnosis and management.

Objective: Compare serum metabolomics of KPD, T1D, and T2D patients during hyperglycemic crises, and utilize classification and regression tree (CART) modeling to distinguish these forms of diabetes.

Methods: At an urban hospital emergency center, adults with KPD, T1D, and T2D during hyperglycemic crises with or without diabetic ketoacidosis (DKA), and healthy controls, underwent comparisons of serum metabolite and hormonal profiles and CART analyses. …

Artificial Intelligence In Head And Neck Cancer: Towards Precision Medicine, Jacob Hagen, Logan Hornung, William Barham, Supratik Mukhopadhyay, Adam Bess, Kevin Contrera, Devraj Basu, Vlad Sandulache, Guillaume Spielmann, Sagar Kansara

Faculty, Staff and Students Publications

Over the past 20 years, the capabilities of artificial intelligence (AI) have gained significant interest. While AI has been implemented to various degrees in several disciplines, its unique applications in head and neck cancer (HNC) remain underdeveloped. This narrative review examines the existing body of literature regarding the use of AI in HNC. Studies to date have demonstrated AI’s utility across multiple phases of the HNC treatment continuum. Despite its promise, integrating AI into clinical practice faces several challenges, including concerns about system integrity, generalizability, privacy, and bias. In this review, we address these challenges and offer insights into future …

Be Your Own Brain Advocate: Why Older People Should Request Routine Cognitive Testing, Josey M. Batura, Elizabeth B. Fauth

All Current Publications

Your primary care physician can conduct regular screenings and track cognitive changes; however, patients may need to advocate for and request testing. If there is noticeable loss in cognitive function, you may benefit from a more accurate diagnosis and a treatment plan or care plan from a medical specialist. Detecting cognitive changes early is better than knowing too late.

Reeds Run Amok: A Practical Guide To Managing Phragmites-Invaded Wetlands, Christine Rohal, Keith Hambrecht, Chad Cranney, Karin M. Kettenring

All Current Publications

Phragmites australis (common reed or simply “phragmites”) is a tall-statured, highly productive wetland grass. It spreads rapidly, often displacing native plants and degrading critical habitat for shorebirds and waterfowl by reducing the availability of nesting, loafing, and foraging areas. Phragmites also consumes large amounts of water, adding pressure to already scarce water resources. Additionally, the accumulation of standing dead biomass can be a fire hazard. Phragmites makes large areas of wetlands inaccessible to both wildlife and humans. This guide provides guidance on managing phragmites.

Butte Priority Soils Operable Unit (Bpsou) Superfund Operation And Maintenance (O&M) Request For Maintenance – Kelley Stormwater Channels (Dated April 22, 2025), Josh Bryson

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Evaluation Of Home Modifications For Individuals With Mobility Impairments Using Virtual Reality And Wearable Sensors, Yue Luo, Jithin Gopinadhan, Nicolas S. Grimaldi, Xiaojie Lu, Sherry Ahrentzen, Ravi Srinivasan, Boyi Hu

Faculty Research, Scholarly, and Creative Activity

Background: Home repurposing can help enhance accessibility for people with mobility impairments. However, residents may hesitate to implement such changes without clear evidence showing the effectiveness. Purpose: The study integrates virtual reality (VR) systems and wearable technology to provide the effectiveness evidence of home repurposing, reducing residents’ hesitancy. Here, VR allows residents to compare old and new home designs, while wearables offer direct evidence through motion and task analysis. Methods: Twenty-one participants conducted two consecutive activities of daily living (i.e., relocating the robe and going to the bathroom) in original and redesigned bedrooms simulated in the VR system. Participants’ performance …

A Single Center Study Of The Symbol Digit Modalities Test As A Screening Tool For Cognitive Impairment In Parkinson’S Disease, Daniyell Thomason, Morganne Manuel, Shannin Moody, Jesus Lovera, Brain Copeland, Deidre Devier

School of Medicine Faculty Publications

Background: Parkinson’s Disease (PD) can include physical signs and possibly cognitive impairment, resulting from the convergence of pathologicalprocesses involving dopaminergic dysfunction, accumulation ofalpha-synuclein, cholinergic deficits, and disruption of otherneurotransmitter systems. We used screening tests to evaluate thecharacteristics of cognitive performance in patients with PD and to assess their validity compared tothe Montreal Cognitive Assessment (MoCA). Methods: This is a natural history study of participants with PD and controls screened for possible cognitive impairment using the MoCA, Symbol Digit Modalities Test (SDMT), and King-Devick (KD). The groups were compared on performance and then factors associated with cognitive performance (age, diagnosis, and …