Digital Commons Network^™

Adaptive And Robust Smartphone-Based Step Detection In Multiple Sclerosis, Lorenza Angelini, Dimitar Stanev, Marta Plonka, Rafal Kilmas, Natan Naplorkowski, Gaby Gonzalez Chan, Lisa Bunn, Paul Glazier, Richard Hosking, Jennifer Freeman, Jeremy Hobart, Jonathan Marsden, Licinio Craveiro, Mike D. Rinderknecht, Mattia Zanon

School of Health Professions

Background: Many attempts to validate gait pipelines that process sensor data to detect gait events have focused on the detection of initial contacts only in supervised settings using a single sensor. Objective: To evaluate the performance of a gait pipeline in detecting initial/final contacts using a step detection algorithm adaptive to different test settings, smartphone wear locations, and gait impairment levels. Methods: In GaitLab (ISRCTN15993728), healthy controls (HC) and people with multiple sclerosis (PwMS; Expanded Disability Status Scale 0.0-6.5) performed supervised Two-Minute Walk Test [2MWT] (structured in-lab overground and treadmill 2MWT) during two on-site visits carrying six smartphones and unsupervised …

Structural Basis For Mtorc1 Activation On The Lysosomal Membrane, Zhicheng Cui, Alessandra Esposito, Gennaro Napolitano, Andrea Ballabio, James H Hurley

Duncan NRI Faculty and Staff Publications

The mechanistic target of rapamycin complex 1 (mTORC1) integrates growth factor (GF) and nutrient signals to stimulate anabolic processes connected to cell growth and inhibit catabolic processes such as autophagy1,2. GF signalling through the tuberous sclerosis complex regulates the lysosomally localized small GTPase RAS homologue enriched in brain (RHEB)3. Direct binding of RHEB-GTP to the mTOR kinase subunit of mTORC1 allosterically activates the kinase by inducing a large-scale conformational change4. Here we reconstituted mTORC1 activation on membranes by RHEB, RAGs and Ragulator. Cryo-electron microscopy showed that RAPTOR and mTOR interact directly with the membrane. Full engagement of the membrane anchors …

Galntl5 Binds Galnac And Is Required For Migration Through The Uterotubal Junction And Sperm-Zona Pellucida Binding, Taichi Noda, Reika Uriu, Daisuke Mashiko, Hina Shinohara, Yongcun Qu, Ayumu Taira, Ryan M Matzuk, Duri Tahala, Motochika Nakano, Kimi Araki, Zhifeng Yu, Ying Zhang, Martin M Matzuk, Masahito Ikawa

Faculty, Staff and Students Publications

Objective: To review the global impact of the COVID-19 pandemic on stroke care-metrics and report data from a health system in Houston.

Methods: We performed a meta-analysis of the published literature reporting stroke admissions, intracerebral hemorrhage (ICH) cases, number of thrombolysis (tPA) and thrombectomy (MT) cases, and time metrics (door to needle, DTN; and door to groin time, DTG) during the pandemic compared to prepandemic period. Within our hospital system, between January-June 2019 and January-June 2020, we compared the proportion of stroke admissions and door to tPA and MT times.

Results: A total of 32,640 stroke admissions from 29 studies …

Galntl5 Binds Galnac And Is Required For Migration Through The Uterotubal Junction And Sperm-Zona Pellucida Binding, Taichi Noda, Reika Uriu, Daisuke Mashiko, Hina Shinohara, Yongcun Qu, Ayumu Taira, Ryan M Matzuk, Duri Tahala, Motochika Nakano, Kimi Araki, Zhifeng Yu, Ying Zhang, Martin M Matzuk, Masahito Ikawa

Faculty, Staff and Students Publications

More than 20 genes expressed in the male reproductive tract have been identified as essential factors for sperm migration to and through the utero-tubal junction (UTJ), and they are divided into ADAM3-dependent and ADAM3-independent pathways. In parallel, sperm having UTJ migration defects also show impaired binding to the zona pellucida (ZP). Herein, we demonstrate that knockout of Galntl5, encoding a sperm surface protein, causes impaired sperm binding with the UTJ and ZP, and null males have severe infertility. GALNTL5 appreciably disappears in sperm lacking Adam3 or Lypd4, required for ADAM3-dependent and ADAM3-independent pathways, and GALNTL5 binds to N …

Enhancing Clinical Named Entity Recognition Via Fine-Tuned Bert And Dictionary-Infused Retrieval-Augmented Generation, Soumya Challaru Sreenivas, Saqib Chowdhury, Mohammad Masum

Faculty Research, Scholarly, and Creative Activity

Clinical notes often contain unstructured text filled with abbreviations, non-standard terminology, and inconsistent phrasing, which pose significant challenges for automated medical information extraction. Named Entity Recognition (NER) plays a crucial role in structuring this data by identifying and categorizing key clinical entities such as symptoms, medications, and diagnoses. However, traditional and even transformer-based NER models often struggle with ambiguity and fail to produce clinically interpretable outputs. In this study, we present a hybrid two-stage framework that enhances medical NER by integrating a fine-tuned BERT model for initial entity extraction with a Dictionary-Infused Retrieval-Augmented Generation (DiRAG) module for terminology normalization. Our …

Salvage Therapies For First Relapse Of Shh Medulloblastoma In Early Childhood., Craig Erker, Martin Mynarek, Marie Simbozel, Brandon T. Craig, Virginia L. Harrod, Andrea M. Cappellano, Kenneth J. Cohen, Vicente Santa-Maria Lopez, Andres Morales La Madrid, Chantel Cacciotti, Lorena Baroni, Ralph Salloum, Ashley S. Margol, George Michaiel, Dolly Aguilera, Claire M. Mazewski, Cassie N. Kline, Jonathan L. Finlay, Mohamed S. Abdelbaki, Jeffrey C. Murray, Kathleen Dorris, Bruce Crooks, Kevin Ginn, Nisreen Amayiri, Stephan Tippelt, Gudrun Fleischhack, Svenja Tonn, Nicolas U. Gerber, Alvaro Lassaletta, Jordan R. Hansford, Sara Khan, Stephen W. Gilheeney, Lindsey M. Hoffman, Michal Zapotocky, Valérie Larouche, Shafqat Shah, Vijay Ramaswamy, Amar Gajjar, Sébastien Perreault, Sabine Mueller, Juliette Hukin, Sylvia Cheng, Zhihong J. Wang, Kara Matheson, Simon Bailey, Eric Bouffet, Steven C. Clifford, Giles Robinson, Christelle Dufour, Stefan Rutkowski, Lucie Lafay-Cousin

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Sonic hedgehog (SHH) medulloblastoma is the most common molecular group of infant and early childhood medulloblastoma (iMB) and has no standard of care at relapse. This work aimed to evaluate the post-relapse survival (PRS) and explore prognostic factors of patients with nodular desmoplastic (ND) and/or SHH iMB.

METHODS: This international retrospective study included 147 subjects diagnosed with relapsed ND/SHH iMB between 1995 and 2017, < 6 years old at original diagnosis, and treated without initial craniospinal irradiation (CSI). Univariable and multivariable Cox models with propensity score analyses were used to assess PRS for those in the curative intent cohort.

RESULTS: The 3-year PRS was 61.6% (95% confidence interval [CI], 52.2-69.6). The median age at relapse was 3.4 years (interquartile range [IQR], 2.6-4.1). Those with local relapse (40.8%) more often received salvage treatment with surgery …

Effect Of Gingival Pigmentations And Anterior Crown Heights On Smile Attractiveness Regarding Gingival Exposure Assed By Orthodontists, Dentists, And Laypeople: A Randomized Controlled Trial, Ziad Tannoury, Marianne Moussallem, Joseph Ghoubril, Adib Kassis, Elie Khoury

International Arab Journal of Dentistry

Objectives: The purpose of this study was to evaluate the effect of gingival pigmentations and anterior crown heights in conjunction with the maxillary gingival display on the perception of smile attractiveness assessed by orthodontists, dentists, and laypersons.

Methods: Frontal intraoral photograph of ideally aligned teeth was modified to generate 3 levels of gingival smile exposure (2 mm, 3 mm, and 4 mm) with 4 different degrees of gingival pigmentation index according to DOPI and 5 different central incisors crown heights (7.7 mm, 8.7 mm, 9.7 mm, 10.7 mm, and 11.7 mm). Attractiveness of these 24 smiles was evaluated by orthodontists …

Predictors Of All-Cause In-Hospital Mortality In Patients With Malignant Well-Differentiated Gastroenteropancreatic Neuroendocrine Tumors, Elvis Obomanu, Tarfa Verinumbe, Tinsae Anebo, Colton Jones, Claudia Dourado

Einstein Health Papers

BACKGROUND: Factors influencing in-hospital mortality in patients with well-differentiated gastroenteropancreatic neuroendocrine tumors (GEP-NETs) remain understudied, highlighting gaps in optimizing acute clinical outcomes. This study aimed to identify sociodemographic and clinical predictors of all-cause in-hospital mortality in this population.

METHODS: Using 2016 - 2020 data from the National Inpatient Sample (NIS), patients with malignant well-differentiated GEP-NETs were identified via the International Classification of Diseases, 10th Revision (ICD-10) codes. The primary outcome was in-hospital mortality. Sociodemographic and clinical variables (heart failure (HF), malnutrition, Charlson Comorbidity Index (CCI), and tumor site) were analyzed using multivariable logistic regression.

RESULTS: Among 5,642 patients (mean age …

The “Geography Of Opportunity” In Flyover Country: A College Match Case Study, Sabrina C. Gregersen, Joanna Full, Meghan Ecker-Lyster

Mid-Western Educational Researcher

In previous studies of college match, specifically undermatching and its far-reaching consequences among traditionally underserved students, students’ geographic proximity to postsecondary institutions (particularly those with which they match) has not always received much consideration. As it stands, the scholarly consensus on college match is not representative of students who live far from regions that are rich with college options of all levels. We evaluated the college match outcomes of 334 high school graduates from a public school district in the Midwest that has a relatively low concentration of colleges nearby. We categorized college match using student competitiveness based on GPA …

Expertise In Impact: Enhancing Researcher Discoverability And Knowledge Mobilization Through Ai In A Rims-Driven Environment, Mackinley Darlington, Sean Newell, Paul Daniels

International Forum on Expert Finder Systems

Athabasca University is pioneering an innovative approach to address the growing demand for universities to demonstrate the societal impact of their research. As the need to showcase tangible outcomes becomes increasingly critical, measuring and articulating impact remains a complex challenge.

Our session will offer an exploration of our journey with Elsevier's Pure Impact AI tool. With the support of Elsevier's Pure Impact AI, Athabasca is leading the way in developing a holistic, nuanced, and multifaceted solution to capture both qualitative and quantitative metrics of research impact. Attendees will learn how this advanced AI tool enables academic leaders and research administrators …

Inside Wamh, January 2008, Advocate Health - Midwest

Historical Documents - Combined

West Allis Memorial Hospital, West Allis, WI: Inside WAMH is a monthly newsletter for employees, volunteers, and guests of the hospital. This issue has a feature on Acute Care for the Elderly (ACE).

Inside Wamh, February 2008, Advocate Health - Midwest

Historical Documents - Combined

West Allis Memorial Hospital, West Allis, WI: Inside WAMH is a monthly newsletter for employees, volunteers, and guests of the hospital. This issue has information on a pilot Open Medical Record program.

Inside Wamh, March 2008, Advocate Health - Midwest

Historical Documents - Combined

West Allis Memorial Hospital, West Allis, WI: Inside WAMH is a monthly newsletter for employees, volunteers, and guests of the hospital. This issue announces the hospital now has Wi-Fi.

Inside Wamh, April 2008, Advocate Health - Midwest

Historical Documents - Combined

West Allis Memorial Hospital, West Allis, WI: Inside WAMH is a monthly newsletter for employees, volunteers, and guests of the hospital. This issue announces that the hospital was named a top 100 hospital nationally by Thomson Healthcare.

Inside Wamh, May 2008, Advocate Health - Midwest

Historical Documents - Combined

West Allis Memorial Hospital, West Allis, WI: Inside WAMH is a monthly newsletter for employees, volunteers, and guests of the hospital. This issue announces the hospital will now be called Aurora West Allis Medical Center.

This is the final issue titled Inside WAMH. The publication continues with the name Inside AWAMC.

Inside Awamc, June 2008, Advocate Health - Midwest

Historical Documents - Combined

Aurora West Allis Medical Center, West Allis, WI: Inside AWAMC is a monthly newsletter for employees, volunteers, and guests of the hospital. There is a feature on patient education for heart failure.

This is the first issue with the new name. This publication continues Inside WAMH.

Inside Awamc, July 2008, Advocate Health - Midwest

Historical Documents - Combined

Aurora West Allis Medical Center, West Allis, WI: Inside AWAMC is a monthly newsletter for employees, volunteers, and guests of the hospital. This issue announces that Aurora Health Care was named a top performing health system nationally by Centers for Medicare & Medicaid Services.

Inside Awamc, August 2008, Advocate Health - Midwest

Historical Documents - Combined

Aurora West Allis Medical Center, West Allis, WI: Inside AWAMC is a monthly newsletter for employees, volunteers, and guests of the hospital. This issue features a new initiative in improving patient experiences. There is also an announcement about nurses wearing new "RN" badges on their nametags for easy identification.

Inside Awamc, September 2008, Advocate Health - Midwest

Historical Documents - Combined

Aurora West Allis Medical Center, West Allis, WI: Inside AWAMC is a monthly newsletter for employees, volunteers, and guests of the hospital. This issue announces that the medical center was named a Performance Improvement Leader by Tomson Healthcare. Also included are new National Patient Safety Goals for 2009.

Inside Awamc, October 2008, Advocate Health - Midwest

Historical Documents - Combined

Aurora West Allis Medical Center, West Allis, WI: Inside AWAMC is a monthly newsletter for employees, volunteers, and guests of the hospital. This issue has a feature on the work of hospitalists.

Inside Awamc, November 2008, Advocate Health - Midwest

Historical Documents - Combined

Aurora West Allis Medical Center, West Allis, WI: Inside AWAMC is a monthly newsletter for employees, volunteers, and guests of the hospital. This issue includes announcements of programs and services.

Inside Awamc, December 2008, Advocate Health - Midwest

Historical Documents - Combined

Aurora West Allis Medical Center, West Allis, WI: Inside AWAMC is a monthly newsletter for employees, volunteers, and guests of the hospital. This issue includes announcements of programs and services.

Inside Awamc, January 2009, Advocate Health - Midwest

Historical Documents - Combined

Aurora West Allis Medical Center, West Allis, WI: Inside AWAMC is a monthly newsletter for employees, volunteers, and guests of the hospital. This issue has a feature on improving patient experiences.

Inside Awamc, February 2009, Advocate Health - Midwest

Historical Documents - Combined

Aurora West Allis Medical Center, West Allis, WI: Inside AWAMC is a monthly newsletter for employees, volunteers, and guests of the hospital. This issue has a feature about the Daisy Award.

Inside Awamc, March 2009, Advocate Health - Midwest

Historical Documents - Combined

Aurora West Allis Medical Center, West Allis, WI: Inside AWAMC is a monthly newsletter for employees, volunteers, and guests of the hospital. This issue has information about the hospital's new 'green' initiatives and introduces 'huddles' as a a new communication tool for teams.

Inside Awamc, April 2009, Advocate Health - Midwest

Historical Documents - Combined

Aurora West Allis Medical Center, West Allis, WI: Inside AWAMC is a monthly newsletter for employees, volunteers, and guests of the hospital. This issue has a feature on the hospital's SHHH campaign to promote noise reduction in patient areas.

Inside Awamc, May 2009, Advocate Health - Midwest

Historical Documents - Combined

Aurora West Allis Medical Center, West Allis, WI: Inside AWAMC is a monthly newsletter for employees, volunteers, and guests of the hospital. This issue announces that the hospital was named a top 100 hospital nationally by Thomson Healthcare.

Inside Awamc, June 2009, Advocate Health - Midwest

Historical Documents - Combined

Aurora West Allis Medical Center, West Allis, WI: Inside AWAMC is a monthly newsletter for employees, volunteers, and guests of the hospital. This issue announces the hospital expects a full three-year accreditation from the Joint Commission.

Inside Awamc, July 2009, Advocate Health - Midwest

Historical Documents - Combined

Aurora West Allis Medical Center, West Allis, WI: Inside AWAMC is a monthly newsletter for employees, volunteers, and guests of the hospital. This issue has a feature on FAST Stroke education.

Inside Awamc, August 2009, Advocate Health - Midwest

Historical Documents - Combined

Aurora West Allis Medical Center, West Allis, WI: Inside AWAMC is a monthly newsletter for employees, volunteers, and guests of the hospital. This issue has a feature on new technology in the NICU.