Digital Commons Network^™

Precision Nanomedicine For Anxiety: Challenges, Opportunities, And Future Directions In Targeted Drug Delivery, Sehrabpreet Singh, Amanpreet Singh, Shruti Chittu, Shailesh Sharma

Journal of Food and Drug Analysis

Nanoparticle-based drug delivery system represents one of the challenging strategies suggested to improve anxietydisorder therapeutic approaches, clinic challenges of delayed action, side effect-free designing and poor patientcompliance. Traditional pharmacological agents can increase drug bioavailability and target specific brain regions,whereas nanoparticle-mediated controlled release offers enhanced precision and sustained action. The others in thisreview concentrate on several kinds of nanoparticle, including lipid-based, polymeric-metallic, and responsive nano-particles, their use in anxiety medication. In addition, emphasis is placed on precision medicine that pertain the delivery of treatment based on an individual's genetic, environmental and lifestyle aspects. Also, it is looked into how artificial intelligence …

The Rhythm Of Decline: Circadian Disruption In Neurodegeneration, Jeewanjot Singh, Devinder Kumar, Jasleen Kaur, Amanpreet Singh

Journal of Food and Drug Analysis

Alzheimer's disease (AD) is a progressive neurodegenerative disorder with a multifactorial etiology involving genetic,environmental, and metabolic factors. Among these, circadian rhythm disruption has emerged as a crucial but under-explored contributor to disease progression. The circadian system, regulated by the suprachiasmatic nucleus (SCN),controls essential physiological functions such as the sleep-wake cycle, metabolism, and neuroendocrine signaling.Disruption of this system has been increasingly linked to key pathological features of AD, including amyloid-betaaccumulation, tau hyperphosphorylation, and neuroinflammation. This review critically examines the mechanistic roleof circadian misalignment in AD by analyzing studies on sleep disturbances, SCN degeneration, metabolic dysregu-lation, clock gene polymorphisms (BMAL1, CLOCK, PER, …

Targeted Nanosponge-Based Treatment For Pulmonary Hypertension: A Novel Approach, Jashanpreet Kaur, Gursimran Kaur, Chamanpreet Kaur, Sandeep Kumar

Journal of Food and Drug Analysis

Pulmonary Hypertension (PH) is a progressive and potentially fatal condition marked by high pulmonary arterypressure, resulting in heart failure and reduced oxygenation. Despite advancements in treatments, therapeutic optionsfor PH remain limited, particularly in cases resistant to conventional therapies. In biomedical research, nanotechnologyhas become a potential area of study, presenting novel approaches to drug delivery and tissue targeting. Nanosponges, aclass of nanoparticles with porous structures, have gained attention for their ability to encapsulate therapeutic agents,enhance drug stability, and provide controlled release. Nanosponges can be engineered to deliver vasodilators, anti-inflammatory drugs, and gene therapies directly to the pulmonary vasculature, minimizing systemic side …

In Vivo And In Vitro Perspectives In Parkinson's Disease: Mechanisms And The Role Of Phytomedicine, Jeewanjot Singh, Devinder Kumar

Journal of Food and Drug Analysis

Parkinson's disease (PD) is a progressive neurodegenerative disorder marked by dopaminergic neuronal loss,oxidative stress, neuroinflammation, and a-synuclein aggregation. Despite advances, current treatments only offersymptomatic relief without altering disease progression. This review aims to evaluate the therapeutic potential of plant-derived phytochemicals in PD through evidence from both in vivo and in vitro experimental models. Key findingsindicate that rodent models (e.g., MPTP, rotenone) and neuronal cell lines (e.g., SH-SY5Y) help replicate PD pathologyand mechanistic insights. Phytochemicals such as baicalein, morin, ferulic acid, and bacopa demonstrate neuroprotectiveeffects via antioxidant, anti-inflammatory, and mitochondrial-stabilizing pathways. Nanotechnology and brain orga-noids further improve translational relevance. In conclusion, …

Global Research Trends On Avocado Oil And Its Fatty Acid Composition: A Bibliometric Review, Ahmad Kamrullah Aras, Abdul Rohman

Journal of Food and Drug Analysis

The high content of unsaturated fatty acids in avocado oil (Persea americana) has prompted in-depth exploration across research subjects. This study uses bibliometric analysis to assess global research trends on avocado oil and its fatty acid composition from 2004 to 2024. The search string retrieved 255 articles from the Scopus database and then analyzed using R BibliometriX and VOSviewer software. These tools analyze descriptive structures and collaborative patterns and create network data maps. For comparison, we separated the data into two research periods, namely 2004-2013 and 2014-2024. There was a significant increase in the number of publications, with …

Factors Influencing The Use Of Gis-Enabled Public E-Participation For Municipal Solid Waste Management, Irene Arinaitwe, Agnes Nakakawa, Gilbert Maiga

The African Journal of Information Systems

Due to rapid global population growth and urbanization, approximately two billion metric tons of waste are generated annually. Municipal solid waste management has become a critical function for urban authorities. However, many urban authorities in low- and middle-income economies cannot provide efficient municipal solid waste management services because of suboptimal stakeholder participation in governance processes and inadequate information exchange. Therefore, this study sought to determine factors that influence the implementation of GIS-enabled public e-participation using Enhanced Adaptive Structuration Theory. A descriptive field study was conducted among staff of municipal authorities and residents in Uganda’s Kampala Metropolitan Area. Data were analyzed …

Resonanceos The Firmware Of Reality (((Qpie))) Prior Art Claims, Teddy Burroughs

Defensive Publications Series

(((QPIE))) ResonanceOS: A Manifesto and Public Invitation to the Hidden Firmware of Reality

Timestamp: September 17, 2025 — America/New_York Author: Ted Funding, Avision4Change ([email protected])

1) Opening Invocation — A Quantum Gift for the People

We begin with a claim that carries the weight of centuries: reality runs on hidden firmware. Beneath the equations, beneath the models, beneath the arguments about what is real, there is resonance — patterns of coherence moving through apparent noise. For too long, institutions have thrown away the noise, treating it as nuisance rather than teacher. For too long, we have fragmented our sciences, …

Pharmaceutical Compositions Of Ciprofloxacin, Anonymous

Defensive Publications Series

The present invention relates to a stable solid pharmaceutical composition comprising Fluoquinolones or a pharmaceutically acceptable salt thereof, one or more Nitrite scavengers and pharmaceutically acceptable excipients.

Efficacy Of Pethidine And Tramadol In The Suppression Of Postoperative Shivering: A Comparative Study, Ahmed Jaber Ibrahim, Hussien Ibrahim Hayal, Ahmed R.Y. Al-Sawad, Shahab Abdulla, Ralela Makline

AUIQ Complementary Biological System

Postoperative shivering is a common complication that can affect patient comfort and stability. Pethidine and tramadol are widely used to relieve this symptom, but their relative effectiveness and safety remain under investigation. In this randomized trial, 50 patients (aged 25–35 years) with postoperative shivering were divided into two groups: one group receiving intravenous tramadol (n = 25 patients) and one group receiving pethidine (n = 25 patients). Onset of drug action, vital signs, and side effects were systematically assessed. Pethidine had a significantly faster onset of action than tramadol (12.20 ± 0.35 min vs 7.16 ± 0.28 min, p < 0.001). No significant differences were observed between the two groups regarding body temperature, heart rate, oxygen saturation, or blood pressure (P < 0.05). Side effects, such as dizziness (16% vs. 8%), nausea and vomiting (20% vs. 8%), and nausea alone (48% vs. 20%), were more common and showed a statistically significant increase in the tramadol group. Both drugs were effective in suppressing postoperative tremor, but pethidine demonstrated superior efficacy, a faster onset of action, and a better safety profile. These results confirm pethidine as the recommended choice at an intravenous dose of 0.5 mg/kg.

Comparative Analysis Of Life Cycle Assessment Of Traditional And Contemporary Timber Buildings, Sadık Akşar, Gökçe Tuna

Journal of Sustainable Construction Materials and Technologies

Wood has long been used as a primary building material, but with the Industrial Revolution and the spread of multi-story structures, its structural limitations became evident. In the 21st century, engineered timber products have reintroduced wood as a sustainable alternative, offering advantages such as lightness, rapid assembly, and recyclability. At the same time, buildings are responsible for significant environmental impacts, making assessment methods essential. Life Cycle Assessment (LCA) is one of the most widely used tools for evaluating these impacts across all stages of a building’s life cycle. This study applies LCA to timber construction systems, focusing on both traditional …

Sustainable Paving Block Development: Utilizing Rejected Coal As Filler And Assessing Its Impact On Paving Block’S Properties, Siti Nikmatin, Allen Kurniawan, Heriansyah Putra, Rima Fitria Adiati, Riawan Ma’Ruf, Dwi Arso Yedi Irwanto

Journal of Sustainable Construction Materials and Technologies

This study investigated the potential use of rejected coal as a fine aggregate filler in paving block production. Comprehensive characterization of the rejected coal was conducted, including toxicity, physical, chemical, and mineralogical analyses of the coal. The results showed that the rejected coal met environmental safety standards (TCLP) and had suitable properties as an aggregate. Paving blocks were produced by incorporating different proportions of rejected coal fillers and were tested for compressive strength, water absorption, and density. The optimal mix with 35% rejected coal filler as a replacement of stone ash achieved a compressive strength of 14.61 MPa, water absorption …

The Antelope, University Of Nebraska At Kearney

The Antelope

No abstract provided.

Patient Education Following Acute Stroke And Transient Ischemic Attack, Elizabeth Amma Vincent

Group: Nebraska Methodist College

Background: Stroke and transient ischemic attack (TIA), have an increasing impact on society through medical costs, low wages, and the burden on society and individuals. To prevent stroke or TIA reoccurrence, education needs to be accessible and presented in a way that gives patients the tools needed to make necessary lifestyle changes and recognize signs and symptoms of when to seek medical attention.

Objective: The objective of this study was to determine if providing an educational program on stroke and transient ischemic attack resulted in increased knowledge about the importance of adopting lifestyle behaviors following stroke or transient ischemic attack, …

Student Senate Meeting Minutes September 17, 2025, Student Senate-Winona State University

Student Senate Meeting Minutes

This document is the official Winona State University Student Senate Minutes for September 17, 2025.

School Resource Officers’ Perceptions Of Their Role And The Effects Of Their Interactions With Students, Tameka Arlene Elizabeth Evans

Walden Dissertations and Doctoral Studies

The use of school resource officers (SROs)—trained police officers who have been assigned to schools—has markedly increased with the rise in school shootings in the United States. However, after several high-profile incidents of excessive force by SROs, there has been a movement toward removing them from schools. Although researchers have studied the use of SROs in schools, few have examined how the relationship between SROs and students affects students’ perceptions of the police. The purpose of this study was to increase the understanding of how SROs experience their interactions with students and how those interactions affect students' perceptions of police …

Illegal Corporate Cultures, Elise Bernlohr Maizel

Duke Law Journal

Culture is a powerful force in corporate compliance. Corporate culture shapes how employees behave, dictating whether, when, and how they follow the law. Cases arising out of cultural failures often involve public harm—plane crashes, poisoned rivers, tainted cancer drugs, and collapsed mines. Before these awful outcomes, however, the corporations that caused these harms fostered cultures that permitted the disregard of legal commands and public commitments. Managers disparaged safety regulations. Messages about profits and production drowned out messages about compliance and safety. Yet, there is a gap between all we know about the power of culture and our understanding of corporate …

September 17, 2025 Blazer Weekly, University Of Alabama At Birmingham

Blazer Weekly (student newsletter)

No abstract provided.

State Of California Cannabis Reporting, University Of Mississippi – National Center For Cannabis Research And Education

California

No abstract provided.

A Content Analysis Of Prison/Custodial Suicide In Bangladesh, Anisur Khan, Rasel Hussain

Journal of Social, Behavioral, and Health Sciences

Suicide is the leading cause of death in prisons and custodial settings globally. International studies have consistently shown that prisoners and detainees are at a higher risk of suicide compared to the general population. Despite Bangladesh having a large prison population, there is no scholarly work on suicide within these settings. Against this backdrop, this study explored online newspaper content analysis capturing the characteristics of prison and custodial suicide in Bangladesh from 2014–2024. A total of 20 suicide cases were identified during this period. The data were arranged based on year-wise trends, age, sex, type of custody, nature of criminality, …

Examining The Effects Of Firearm Lethality And Aggressors’ Intentions To Kill On Injurious Firearm Violence At American Schools: A Research Note, Brent R. Klein, Cory Schnell, Steven M. Chermak, Joshua D. Freilich

Faculty Publications

This study examined firearm lethality and aggressors’ lethal intent on injurious fatal and nonfatal school shootings using data from The American School Shooting Study, which covers 329 school shootings in the United States from 1990 to 2016. We developed a new multidimensional construct for measuring shooters’ determination to kill and examined firearm characteristics while considering confounding factors. We identified 11 distinct categories of shooters’ intent, with most showing a strong desire to kill. Both intent and weapon lethality significantly impacted school shooting homicides. Overall, we recommend that prevention and theoretical models should address both factors.

Commonwealth Times 2025-09-17

Commonwealth Times, 1969-

No abstract provided.

Reducing Stigma And Enhancing Outcomes: An Antistigma Education Program For Mental Healthcare Professionals, Chidi Oriaku

Walden Dissertations and Doctoral Studies

This Doctor of Nursing Practice (DNP) project was a staff education project that addressed the stigmatization of patients with mental illness (PMI) within psychiatric contexts. The project site healthcare organization’s mental health professionals had a high rate of stigmatization of PMI. Stigma is linked to poor medication adherence rates, delays in accessing healthcare, lower healthcare utilization among PMI, psychiatric morbidity and mortality, and poor quality of life. Despite recognizing this problem, the healthcare organization had no targeted antistigma interventions. I developed an antistigma education to improve outcomes. The practice-focused question was: In mental health staff, will an educational program on …

Outdated U.S. Safety Net Leaving Poor Communities Exposed To “Climate Strains”, Maurer School Of Law - Indiana University

Keep Up With the Latest News from the Law School (blog)

America’s safety net is failing to protect its most vulnerable citizens from the growing pressures of climate change, according to new research from an Indiana University Maurer School of Law Professor Andrew Hammond.

In a new article forthcoming in the Iowa Law Review, Hammond argues that while policymakers, the press, and the public tend to focus on climate “shocks” like hurricanes and wildfires, millions of Americans face overlooked climate “strains”—the everyday stresses of extreme heat, deteriorating air quality, and failing infrastructure that disproportionately affect low-income Americans.

Hammond’s paper, “Climate Strains and the Safety Net,” found that …

Comparison Of Diagnostic Modalities For Carpal Tunnel Syndrome: A Systematic Review, Starlie Belnap, Richard Morgan

All Publications

Carpal tunnel syndrome (CTS) is a common nerve entrapment disorder that affects millions, particularly older adults and women. It causes numbness, tingling, and discomfort in the hand, primarily affecting the median nerve. Risk factors include occupation (e.g., jobs involving repetitive motion or vibrating tools) and conditions such as obesity, pregnancy, and diabetes. Accurate diagnosis is critical for effective treatment, with nerve conduction studies (NCS) and ultrasound (US) being two key diagnostic methods. Each approach has strengths, limitations, and diagnostic utility, necessitating a comparison to determine the best use case for each tool. This comprehensive systematic review aims to compare the …

Ronald Koons V. Attorney General New Jersey

2025 Decisions

USDC for the District of New Jersey

Know Your Tsunami Hazard In Cordova, Beth Grassi, Hannah Chapman-Dutton, Dmitry Nicolsky, Elena Troshina

Alaska Earthquake Center Tsunami Hazard Products

Coastal Alaska communities live with the most serious tsunami hazard in the United States. The Alaska Earthquake Center helps coastal communities prepare for the next tsunami disaster. We provide state and local officials with the best available scientific information for addressing the variety of tsunami hazards faced by their communities. These community-specific brochures distill information from several scientific publications, such as tsunami inundation reports, pedestrian travel time maps, and maritime response guidance, into a handy, quick reference. The brochures include maps with community-designated safety information, links for local and statewide tsunami preparedness information, and more. The brochures are rack-card size …

Daily Eastern News: September 17, 2025, Eastern Illinois University

Daily Eastern News: 2025-2026

No abstract provided.

Transcending Tradition Through Inclusive Online Pedagogy, Areto A. Imoukuede

St. Mary's Law Journal

No abstract provided.

On The Randomness Of Evolutionary Events Along Lineages : Two Case Studies, Hema Dalavayi, Max Garzon

QuaesitUM

No abstract provided.

The Lumberjack, September 17, 2025

Cal Poly Humboldt's Student Newspaper

The student newspaper of Humboldt State University.