Digital Commons Network^™

Human Single-Neuron Activity Is Modulated By Intracranial Theta Burst Stimulation Of The Basolateral Amygdala, Justin M Campbell, Shuo Wang, Lawrence N Eisenman, James Swift, Tao Xie, Peter Brunner, Jon Timothy Willie, Et Al.

2020-Current year OA Pubs

Direct electrical stimulation of the human brain has been used for numerous clinical and scientific applications. At present, however, little is known about how intracranial stimulation affects activity at the microscale. In this study, we recorded intracranial EEG data from a cohort of patients with medically refractory epilepsy as they completed a visual recognition memory task. During the memory task, brief trains of intracranial theta burst stimulation (TBS) were delivered to the basolateral amygdala (BLA). Using simultaneous microelectrode recordings, we isolated neurons in the hippocampus, amygdala, orbitofrontal cortex, and anterior cingulate cortex and tested whether stimulation enhanced or suppressed firing …

Can Predictive And Functional Methods Locate The Dysplastic Hip Joint Center?, Michael Harris, Emma C. Behrman, Keith R. Lohse, Molly C. Shepherd, Bruce A. Macwilliams, Erin M. Mannen

2020-Current year OA Pubs

BACKGROUND: Properly characterizing biomechanics in populations with known hip deformities, such as developmental dysplasia of the hip (DDH), requires accurately identifying the hip joint center (HJC). Many studies have assessed the accuracy or repeatability of predictive and functional methods to locate the HJC in normally shaped hips, but not for hips with DDH.

RESEARCH QUESTION: For patients with DDH, which of three common functional and four common predictive HJC methods is most accurate compared to a magnetic-resonance-imaging-based anatomic method?

METHODS: HJC method accuracy was calculated as the resultant vector distance from the anatomic HJCs. Bias was calculated as distance errors …

1,2,4-Triazole-Based First-In-Class Non-Nucleoside Inhibitors Of The Bacterial Enzyme Mray, Tomayo Berida, Tzu-Yu Huang, Stefanie C Weck, Marcel Lutz, Samuel R Mckee, Nathalie Kagerah, Destinee L Manning, Mohamed E Jahan, Sushil Mishra, Jennifer Herrmann, Rolf Müller, Robert J Doerksen, Christina L Stallings, Christian Ducho, Sudeshna Roy

2020-Current year OA Pubs

MraY is an essential bacterial enzyme for peptidoglycan synthesis in cell walls and serves as a promising but unrealized target for developing effective antibacterial drugs. Nature has provided a remarkable array of nucleoside inhibitors of MraY, and researchers have skillfully refined these structures to develop inhibitors that effectively mimic natural products. Yet, both natural products and their synthetic variants often face challenges regarding inadequate

Strategies Managers Use To Improve Employee Retention, Jeanette L. Moncure

Walden Dissertations and Doctoral Studies

Addressing employee turnover and boosting retention are major challenges for companies looking to achieve long-term success. Project managers are crucial in tackling this issue, as high turnover can undermine team performance and increase operational costs. Grounded in Herzberg’s two factor theory, the purpose of this qualitative case study was to explore strategies that some project managers use to reduce high employee turnover. The participants included six project managers in Mississippi who had an active role in using strategies to increase employee retention. Data were collected using semistructured interviews, organizational documentation, and research statistics. Thematic analysis identified six key strategies: (a) …

Multiple Pathways Of Social Impairment For Youth With Symptoms Of Adhd: A Novel Model Of Serial Mediation, Ewald Michael Wefelmeyer

Dissertations (1934 -)

The current study sought to explain the heterogeneity of social impairment among youth with symptoms of ADHD with the goal of potentially improving a clinician's ability to identify and support those children. A novel model of the relationship between the disorder and social impairment was proposed with serial mediators of parental/family functioning and emotion regulation. It was anticipated that a higher level of ADHD symptoms would lead to more impairment among aspects of parental/family functioning, which would predict more emotion dysregulation which would subsequently predict poorer social functioning. Structural Equation Modeling yielded little support for the overall model and no …

Investigating The Role Of Chaperones And Sequestrases In Misfolded Protein Sequestration, Sarah Rose Rolli

Dissertations (1934 -)

Protein homeostasis, or proteostasis, is responsible for a folded and functional proteome and is essential for cell survival. Proteins can misfold during stress or because of mutation. The accumulation of misfolded proteins is observed in many diseases, including Huntington’s disease. Misfolded proteins will clump together into inclusions, which can be sequestered to membrane-less compartments by proteostasis mechanisms. Several proteins, including chaperones, co-chaperones, and other proteins, have been identified as sequestrases that target inclusions and misfolded proteins to different protein quality control (PQC) compartments. The juxtanuclear quality control (JUNQ) compartment forms in the nucleus-vacuole junction in yeast cells, and several soluble …

Is Academia Becoming Démodé — Or Can It Reinvent Itself?, Essraa Nawar

Library Articles and Research

"And yet, in the wider cultural imagination, academia has become, in many ways, démodé. Out of fashion. Out of step. No longer the epicenter of intellectual authority or social innovation that it once was. The challenge before us is whether we allow academia to drift further toward irrelevance, or whether we reinvent it for the generations now walking through our doors."

Community Survey Report: The Rebuild Survey Conducted In Response To The January 2025 Palisades Fire And Eaton Fire In Los Angeles County, Andrew J. Whelton, Cristiane Ferrarezzi, Lauryn Spearing, Anna Hoover, Mónica Palomo, Caitlin Proctor, Jianxi Su, Joseph Toland

Resilience to Emergencies and Disasters

No abstract provided.

Grit, A Component Of Resident Well-Being, Nathan W. Olson, Kelly Williamson, Nicholas Hartman, Navneet Cheema, Adriana S. Olson

Journal of Wellness

Introduction: Trainees experiencing burnout, depression, or career dissatisfaction challenge educators and may have patient care consequences. Grit, defined as the “perseverance and passion for long-term goals,” buffers against hopelessness and quantifies an aspect of personality shown to predict fewer career changes. Higher grit has been associated with positive outcomes in physicians, including lower burnout rates. Our objective was to determine the correlation between emergency medicine (EM) resident Short Grit Scale (Grit-S) scores and components of well-being: burnout, a positive depression screen, and career satisfaction.

Methods: This was a prospective, multicenter trial involving ten urban/suburban EM residencies. The subjects …

Minutes (9-19-2025), California State University, San Bernardino - Associated Students, Incorporated

Associated Students, Incorporated records

No abstract provided.

Chronic Poppers Maculopathy: Case Report And Literature Comparison Of Chronic And Acute Use, Francesco Cappellani, Caterina Gagliano, Jose S. Pulido

Wills Eye Hospital Papers

RATIONALE: Alkyl nitrites ("poppers") are recreational substances known for their vasodilatory and euphoric effects. Increasing evidence links them to a vision-threatening condition termed poppers maculopathy, characterized by foveal yellow spots and outer retinal changes on optical coherence tomography. While most reports describe acute exposure, little is known about long-term consequences. This case describes one of the longest documented durations of chronic poppers use, combined with a literature review to contextualize the clinical spectrum.

PATIENT CONCERNS: A 68-year-old man with human immunodeficiency virus, type 2 diabetes, hypertension, and depression presented with progressive central vision loss in both eyes persisting for at …

Strategies Human Resource Leaders Use To Increase Employee Retention In The Automotive Industry, Kendra Williams

Walden Dissertations and Doctoral Studies

Excess turnover of personnel threatens organizational viability and long-term success. Human resource leaders need to develop strategies to increase employee retention. Grounded in Herzberg’s two-factor and Maslow’s hierarchy of needs theories, the purpose of this qualitative pragmatic inquiry was to explore and identify successful employee retention strategies employed by human resource leaders to mitigate employee turnover. Data were collected from human resources managers using semistructured interviews and public data from companies’ websites. Through thematic analysis, four themes emerged: (a) job assignment, (b) employee feedback, (c) employee benefits, and (d) training, growth, and development. A key recommendation is for human resource …

Mitochondrial Methylcytosines As Blood-Based Biomarkers For Alzheimer's Disease Dementia Prognosis, Jordi Gascón-Bayarri, Jose Luis Mosquera, Marta Blanch, Pau Martí, Beatriz Fontal, Carla Trapero, Nuria Rojo, Inma Rico, Jaume Campdelacreu, Cristopher Fowler, Simon M. Laws, Adrià Tort-Merino, Raquel Sanchez-Valle, Joan Bello, Juan Fortea, Alberto Lleó, Courosh Mehanian, Russell H. Swerdlow, Ramón Reñé-Ramírez, Marta Barrachina

Research outputs 2022 to 2026

Alzheimer's Disease Dementia (ADD) prognosis is an unmet medical need. Mitochondrial dysfunction is an early AD etiopathogenic factor. The present study analyzed mitochondrial DNA (mtDNA) methylation patterns in blood samples from patients with mild cognitive impairment (MCI) who progressed to ADD (P), MCI remained stable (NP), and Cognitively Normal (CN) individuals. Differentially methylated sites were identified in the D-loop region in both CN vs. NP and NP vs. P comparisons, even before β-amyloid positivity. A Random Forest model was developed using mtDNA methylation data combined with cognitive and risk factor features. Model's performance was assessed by cross-validation and tested on …

Voluntary & Community Organisations: Not The Third But The First Sector Of Integrated Care?, Robin Miller, Michelle Nelson, Ivette Fullerton, Felix Gradinger, James Rees, Marianne Saragosa

Peninsula Medical School

When Mari, a person with diabetes and mental health challenges experiencing homelessness needed care, the hospital could treat their immediate health challenges but couldn’t address why they kept returning. It was a small community organization, with deep neighbourhood knowledge, flexible funding, and trusted relationships—that provided the wraparound support that finally broke the cycle. This story, repeated countless times across health systemsworldwide, raises a fundamental question: Why do we refer to the voluntary and community sector (VCS) as the “third sector” when it’s often the first to respond, innovate, and reach those most in need?Over the past decade, integrated care has …

Identification Of Critical Brain Regions For Autism Diagnosis From Fmri Data Using Explainable Ai: An Observational Analysis Of The Abide Dataset, Suryansh Vidya, Kush Gupta, Amir Aly, Andy Wills, Emmanuel Ifeachor, Rohit Shankar

School of Engineering, Computing and Mathematics

BACKGROUND: Diagnosis of autism spectrum disorder (ASD) significantly improves quality of life, yet current diagnostic practices rely on subjective behavioural assessments. While machine learning models using functional Magnetic Resonance Imaging (fMRI) show promise for objective diagnosis, existing approaches have critical limitations. High-accuracy models often neglect interpretability, increasing clinical distrust, while interpretable approaches frequently suffer from low accuracy and lack neuroscientific validation of identified biomarkers. Furthermore, no studies have systematically benchmarked which interpretability methods are most effective for fMRI data, hindering the translation of Artificial intelligence (AI) findings into clinical practice.

METHODS: In this observational study, we used the Autism Brain …

Financial Inducements In Gambling Marketing: An Information Disclosure Proposal To Inform Gamblers Of Their True Economic Value, Philip Newall, Dominic Cortis, Jamie Torrance

UNLV Gaming Research & Review Journal

Financial inducements such as free bets are frequently-used gambling marketing offers which temporarily improve a gambler’s usual pattern of risk and potential return. Previous research has shown that there are up to 15 distinct types of financial inducements in common use, and that gamblers frequently misunderstand inducements’ play-through requirements and other complex terms and conditions. The Australian government has therefore recently banned play-through requirements for inducements shown to new customers, and the Great British regulator the Gambling Commission has recently announced a maximum play-through requirement of 10 times. The present work describes an alternative and yet potentially complementary approach based …

Human Cerebral Organoids Model Tumor Initiation And Infiltration In An Autologous Astrocyte-Supported Setting, Esther Schickel, Tamara Bender, Leon Kaysan, Simone Hufgard, Margot Mayer, David R Grosshans, Christiane Thielemann, Insa S Schroeder

Faculty, Staff and Student Publications

Efforts to efficiently target brain tumors are constrained by the dearth of appropriate models to study tumor behavior toward treatment approaches as well as potential side effects to the surrounding normal tissue. We established a reproducible cerebral organoid model of brain tumorigenesis in an autologous setting by overexpressing

Ground-Based Modeling Of Deep-Space Risks To The Spleen And Intestine In Mice, Edith Nathalie Pineda Sotomayor

Theses and Dissertations

Deep-space missions, such as those planned for the cis-lunar space and Mars, pose unique challenges to astronaut health due to prolonged microgravity (MG) exposure and low-dose chronic irradiation (CIR). Understanding the impact of these stressors on secondary lymphoid tissues, such as the spleen and intestine, is crucial for ensuring crewmembers' well-being, given the impracticality of conducting this research with human samples. Using a ground-based facility, we exposed C57BL/6 female and male mice to CIR (1.74 Gy at a dose rate of 0.0029 Gy/h) and/or simulated MG (SMG) via hind limb unloading (HLU) for one month. Spleen and intestinal tissues were …

Outcomes Of Liver Transplantation In Patients With Severe Obesity, Alejandro Cracco, Mackenzie Donoho, Siddharth Desai, Meera Gupta, Alexandre Ancheta, Malay B. Shah, Xiaonan Mei, Francesc Marti, Roberto Gedaly

Surgery Faculty Publications

Background. – This study aims to evaluate the impact of obesity on post–liver transplant outcomes stratified by low- and high-performance status. Methods. – Patients undergoing liver transplantation between 2006 and 2023 were identified in the United Network for Organ Sharing data set. Patients with severe obesity body mass index ([BMI] ≥40 kg/m²) and super obesity (BMI >50 kg/m²) were compared with those with lower BMI on perioperative and long-term outcomes stratified by preoperative performance status. Results. – Severe obesity has a significant negative impact on perioperative and long-term outcomes on the low-performance group (LPG). This effect …

Epac1 Deletion Attenuates Müller Glial Pathological Activation And Mitigates Retinal Neurodegeneration In Ischemia-Induced Retinopathy, Shuizhen Shi, Fan Xia, Zhongqiao Lu, Erick Palacios, Fang Mei, Massoud Motamedi, Xiaodong Cheng, Hua Liu, Wenbo Zhang

The Brown Foundation: Institute of Molecular Medicine

Introduction: Ischemia-induced retinopathies, such as retinopathy of prematurity and proliferative diabetic retinopathy, are major causes of vision loss. Both pathological neovascularization and neuronal damage contribute to vision impairment in these conditions, yet current therapies primarily target neovascularization and may further compromise neuronal health.

Objectives: Cyclic AMP (cAMP) is a widely recognized second messenger regulating diverse physiological and pathological processes. Exchange protein directly activated by cAMP (Epac) is a recently identified effector of cAMP signaling. This study aimed to investigate the role of Epac1 in ischemia-induced retinopathy and elucidate its underlying mechanisms using a mouse model of oxygen-induced retinopathy (OIR).

Methods: …

Comparing Regulation With Collective Bargaining: Drawing On Processes Of Change During The Covid-19 Crisis In Israel, Lilach Lurie, Guy Mundlak

Comparative Labor Law & Policy Journal

This article compares two systems of labour market governance: regulation by means of employment standards, and norms that are established in collective bargaining. A comparative framework draws nine criteria, spanning procedural and substantive dimensions, and emphasises the degree of integration between the systems, or “coupling.” The study uses Israel’s response to the COVID-19 crisis as a case study, drawing on a unique dataset of all regulatory provisions and collective agreements concluded from March 2020 to December 2021, supplemented by interviews with key actors. In the public sector, strong coupling was achieved through coordinated regulatory and bargaining processes, resulting in more …

Extensor Retinaculum Capsulorrhaphy And Suture Repair For Ulnocarpal And Distal Radioulnar Joint Instability: One-Year Results, Alex Mafdali, Fady Attalla

All Publications

Purpose: Persistent ulnar-sided wrist pain, often because of triangular fibrocartilage complex (TFCC) tears, can lead to instability of the distal radioulnar joint (DRUJ) and the ulnocarpal joint (UCJ). Although the TFCC's role in stabilizing the DRUJ is well established, its contribution to UCJ stability has gained increasing recognition. This study evaluates the clinical outcomes of combined Herbert Sling and suture repair for (UCJ) instability secondary to TFCC tears.

Methods: Eighty-eight patients (91 wrists) with TFCC tears and UCJ instability, unresponsive to nonsurgical management, underwent combined Herbert sling (HS) and suture repair. The HS technique stabilizes both the DRUJ and UCJ …

Advanced Microstructured Batio3-Embedded Pvdf–Hfp/Peo Film For Enhanced Triboelectric Interface In Self-Sufficient Energy Generation And Sensing, Rigobert Ybarra, Diego De Leon, Michael Moreno, Cesar Sanchez, Fernando Viesca, Kevin Alejandro, Shishir Timilsena, Nicholas Dimakis, Joseph H. Dumont, Tommy Rockward, Tarik J. Dickens, Md. Wasikur Rahman, Mohammed Jasim Uddin

Mechanical Engineering Faculty Publications

The global reliance on fossil fuels and natural gas has largely dominated the energy production field, but due to finite resource depletion and escalating greenhouse gas emissions, the immediate exploration of sustainable energy alternatives to mitigate climate change and ensure resource security has been a major concern. There has been extensive research into other more renewable methods of energy production, such as wind and hydropower. Of these current energy generation types, there are many areas of untapped potential from the mechanical movements generated ambiently not only in the large scale of power generation but also on a smaller scale. The …

Two Essays On Health And Health Behavior In China, Jiamin Tan

Lingnan Theses (MPhil & PhD)

This thesis consists of two empirical studies on elderly mental health and on health behaviors. The first study investigates the long-term impact of childhood hunger on mental health in later life, using data from two nationally representative surveys in China. The study finds that childhood hunger exposure significantly increases the risks of depression and anxiety in later life. These effects are most pronounced among individuals exposed after age 5, suggesting that autobiographical memory formation plays an important role beyond socioeconomic and health pathways. The findings further indicate these impacts can be mitigated through economic interventions, such as welfare programs, and …

Prenatal Metabolomics Analysis And Fetal Congenital Anomalies And Genetic Conditions: A Review Of Current Literature, Sarah Araji, Onur Turkoglu, Mohamad Ali Maktabi, Tracy Ashby, Ignatia B Van Den Veyver

Library Staff Publications

Fetal congenital anomalies and genetic disorders complicate 3%-5% of pregnancies and can have a significant impact on pregnancy outcomes. Precise and individualized prenatal diagnosis is crucial for effective counseling and management. The identification of new biomarkers holds promise for enhancing prenatal screening, diagnosis, and prognostic counseling in affected pregnancies. Recently, metabolomics has emerged as a potential adjunct in the interpretation of genetic variants identified through genome-wide sequencing for rare genetic conditions. To assess the potential of metabolomic profiling as a functional assay capable of providing deeper insights into the pathological processes and genetic findings associated with prenatal congenital anomalies, we …

A Computational Framework For Multi-Scale Analysis Of Mouse Cerebral Blood Flow Regulation, Hadi Esfandi

Electronic Theses and Dissertations

Cerebral hemodynamic imaging is increasingly used as a non-invasive technique to study brain function and dysfunction in both research and clinical settings. Recent advances in imaging technologies have enabled high-speed, high-resolution, whole-brain measurements of blood flow and oxygenation. Improving the interpretation of these cerebral hemodynamic signals through a mechanistic understanding of their cellular drivers would enable more accurate characterization of brain function and pathology. However, no existing biophysical model fully captures the fine-grained dynamics observed in these signals. This dissertation introduces a biophysically grounded computational framework for multi-scale analysis of the mouse cerebral blood flow regulatory system, which captures mechanistic …

Protocol For Non-Invasive Pulsed-Doppler Evaluation Of Blood Flow In The Mouse Ophthalmic Artery, Radwa Awad, Emil Martin, Anilkumar K Reddy, Iraida Sharina

Faculty, Staff and Student Publications

The number of reliable and non-invasive techniques to characterize ocular blood flow is limited. Here, we present a protocol for identifying a soft tissue window in the orbital aperture using pulsed-Doppler ultrasonography to offer real-time, non-invasive blood flow velocity monitoring in the mouse ophthalmic artery. We describe steps for preparing a mouse, positioning the ultrasound probe, and acquiring and recording signals. We then detail procedures for analyzing results using a workstation equipped with Doppler flow velocity software. For complete details on the use and execution of this protocol, please refer to Sharina et al.

Metabolic Shifts In Murine Inner Ears Mimicking Erythrocytes And Plasma Reveal Diagnostics And Early Predictors For Age-Related Hearing Loss, Qi Guo, Zhenjiang Li, Cheng Luo, Changhan Chen, Xi Long, Yidan Wang, Qingfen Qiang, Fang Yu, Wuping Liu, Yujin Zhang, Rodney E Kellems, Yang Xia

Faculty, Staff and Student Publications

Age-related hearing loss (ARHL) is a major public health concern, driven by the interplay of multiple factors. Here, we reveal spatiotemporal metabolic shifts in murine inner ears mirroring erythrocytes and plasma. Isotope-labeled glucose tracing demonstrates a metabolic rerouting favoring glycolysis over the pentose phosphate pathway, alongside downregulation of the tricarboxylic acid cycle, indicating impaired energy production and redox homeostasis. Accumulation of medium- and long-chain acylcarnitines further exacerbates lipotoxicity. Notably, age-dependent depletion of arginine, lysine, proline, and glycine disrupts the arginine-polyamine-urea cycle. Translationally, UK Biobank plasma metabolomics links omega-6 fatty acids, linoleic acid, glycine, and albumin to ARHL resilience, while branched-chain …

The Scarlet - Volume Civ, No. 2 (September 19, 2025), Scarlet Staff

The Scarlet (Student Newspaper) (2011-present)

The September 19, 2025 edition of The Scarlet (est. 1939), Clark University's student-run newspaper. The Scarlet is intellectually and editorially independent of the University.

Trends And Disparities In Acute Coronary Syndrome-Related Mortality In The United States: Implications For Healthcare, Muhammad Khuzzaim Khan, Ibrahim Ahmed Khan, Abdul Moiz Javed, Arslan Wazir, Hira Saleem, Muhammad Zohaib, Faisal Rasheed, Priyanka Mohan Lal, Syeda Laiba Sherazi, Amiaz Karim, Nikhil Duseja, Hussam Al Hennawi

Abington Jefferson Health Papers

Acute coronary syndrome (ACS) is a major cause of morbidity and mortality in the United States (US). However, the trends and disparities in ACS mortality are not well understood. This study aimed to analyze the ACS mortality in the US from 1999 to 2020 using the Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research database. The age-adjusted mortality rates (AAMR) due to ACS were calculated for each year from 1999 to 2020, stratified by sex, race, urbanization, and state. The trends and disparities in AAMR were examined using descriptive statistics and graphical methods. The AAMR due …