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Dairy And Food Science Student Newsletter, October 2, 2025, Department Of Dairy And Food Science

Dairy and Food Science Student Newsletter

No abstract provided.

The Current - Volume 36 Issue 3, Nova Southeastern University

Student Newspapers

No abstract provided.

The Cowl - V. 89 N. 3 - October 2, 2025

The Cowl

The Cowl - student newspaper of Providence College. Vol. 89 No. 3 - October 2, 2025. 20 pages.

Editorial: Decoding Vascular Aging: Unraveling The Enigma Of Pathological Conditions And Pre-Mature Vascular Aging, Mitra Esfandiarei, Roshanak Rahimian

Pacific Faculty Work

No abstract provided.

Wearpghdprovo: An Extension Of Pghdprovo For Wearables, Abdullahi Abubakar Kawu, Dympna O'Sullivan, Lucy Hederman

Research Outputs: 2025-Present

Wearable devices are increasingly used to create patient generated health data (PGHD), yet existing models lack the specificity to fully capture the nuances of this data. This paper presents an initial work on WearPGHDProv, an extension of the PGHDProvO ontology, designed to address this gap. We extended the PGHDProvO ontology using a top-down approach, incorporating concepts from the W3C Provenance Ontology (PROV-O) and domain-specific terms related to wearable devices and data generation. WearPGHDProv introduces new classes and properties to model device-specific information, additional related information unique to wearable data, and the context of data collection. This extension enhances the ability …

2025 October 2 - From My Notepads Newsletter, Office Of The President, East Tennessee State University, Brian Noland

From My Notepads: A Newsletter from President Brian Noland

No abstract provided.

Dual Membrane Receptor Degradation Via Folate Receptor Targeting Chimera, Zhen Wang, Zhixin Li, Jenny Högström, Hiroyuki Inuzuka, Rui Jing, Peiqiang Yan, Tao Hou, Yihang Qi, Daoyuan Huang, Jingchao Wang, Ting Wu, Xiaoying Shi, Bolin Liu, Taru Muranen, Dingpeng Zhang, Wenyi Wei

School of Medicine Faculty Publications

Cancer drug resistance poses a significant challenge in oncology, often driven by intricate cross-talk among membrane-bound receptors that compromise mono-targeted therapies. We develop a dual membrane receptor degradation strategy leveraging Folate Receptor α (FRα) to address this issue. Folate Receptor α Targeting Chimeras-dual (FolTAC-dual) are engineered degraders designed to selectively and simultaneously degrade distinct receptor pairs: (1) EGFR/HER2 and (2) PD-L1/VISTA. Through modular optimization of modality configurations and geometries, we identify the “string” format as the most effective construct. Mechanistic studies demonstrate an ~85% increase in EGFR-binding affinity compared to the conventional knob-into-hole design, likely contributing to the improved efficiency …

In The Matter Of The Parental Rights As To S.A.T., A Minor Child, 141 Nev. Adv. Op. 40 (Oct. 2, 2025), Collin Faught

Nevada Supreme Court Summaries

THE COURT DETERMINED UNDER N.R.S. § 128.105 THAT TOKEN EFFORTS ALONE CANNOT SUPPORT PRIVATE TERMINATION OF PARENTAL RIGHTS AND THAT SILENCE DOES NOT ADMIT FAULT.

Spartan Daily, October 2, 2025, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2025

Volume 165, Issue 18

Genome-Wide Analysis Of Dna Methylation Signatures Linking Prenatal Exposure To The Chinese Great Famine And Blood Lipids In Late Adulthood: The Genomic Research Of The Chinese Famine (Grecf) Study, Huan Wang, Luqi Shen, Tingting Liu, Ruiyuan Zhang, Zhenghe Wang, Jingkai Wei, Ye Shen, Jinzhen Guo, Toni Miles, Changwei Li, Zhiyong Zou

Faculty, Staff and Student Publications

Background/objectives: Prenatal exposure to famine can lead to lasting health effects through changes in DNA methylation. This study aims to evaluate the impact of prenatal exposure to the Chinses Great Famine (1959-1961) on human epigenome and the subsequent influence on blood lipids.

Methods: We conducted an epigenome-wide association study (EWAS) of peripheral blood-based DNA methylation and prenatal exposure to the Chinese Great Famine as well as blood lipids among eight participants exposed to famine and eight sex-matched participants (born ≤ 3 years after the famine). Genome-wide DNA methylation sites were profiled using the Illumina EPIC BeadChip, which covers 850K methylation …

A Mast Cell Receptor Mediates Post-Stroke Brain Inflammation Via A Dural-Brain Axis, Ruchita Kothari, Mostafa W Abdulrahim, Hyun Jong Oh, Daniel H Capuzzi, Collin B Kilgore, Sumil K Nair, Yaowu Zhang, Nathachit Limjunyawong, Sarbjit S Saini, Jennifer E Kim, Justin M Caplan, Fernanado L Gonzalez, Christopher M Jackson, Chetan Bettegowda, Judy Huang, Bhanu P Ganesh, Chunfeng Tan, Raymond C Koehler, Rafael J Tamargo, Louise D Mccullough, Risheng Xu, Xinzhong Dong

Faculty, Staff and Student Publications

The immune environment surrounding the brain plays a fundamental role in monitoring signs of injury. Insults, including ischemic stroke, can disrupt this balance and incite an exaggerated inflammatory response, yet the underlying mechanism remains unclear. Here, we show that the mast-cell-specific receptor Mrgprb2 regulates post-stroke brain inflammation from the meninges. Mrgprb2 causes meningeal mast cell degranulation after stroke, releasing immune mediators. This process recruits skull bone marrow neutrophils into the dura and further promotes neutrophil migration from the dura into the brain by cleaving the chemorepellent semaphorin 3a. We demonstrate that the human ortholog, MRGPRX2, is expressed in human meningeal …

Development Of A Polyvinyl Alcohol-Capped Copper Nanocluster-Integrated Electrochemical Sensor For Trace-Level Monitoring Of Anthraquinone, Saba A Memon, Huma Shaikh, Jamil A Buledi, Amber R Solangi, Saima Q Memon, Tania Ghumro

Faculty, Staff and Student Publications

In the current study, polyvinyl alcohol-capped copper nanoclusters (PVA-CuNCs) were synthesized via a chemical reduction method using PVA as a capping and stabilizing agent. The synthesized PVA-CuNCs were used for the fabrication of an ultra-sensitive electrochemical sensor to detect anthraquinone (AQ) at trace levels in an aqueous environment. The fabricated nanoclusters were thoroughly characterized using a wide range of analytical tools. FTIR analysis confirmed the functional properties of the PVA-CuNCs, while XRD investigation revealed a crystalline nature with an average size of 4.21 nm. Their elemental composition was assessed through EDX, indicating a clean copper-based matrix without any notable impurity. …

Rare Variants In Prkci Cause Van Der Woude Syndrome And Other Features Of Peridermopathy, Kelsey Robinson, Sunil K Singh, Rachel B Walkup, Dorelle V Fawwal, Kendra M Vilfort, Amanda Koloskee, Azeez Fashina, Wasiu Lanre Adeyemo, Terri H Beaty, Azeez Butali, Carmen J Buxó, Wendy K Chung, David J Cutler, Michael P Epstein, Brooklynn Gasser, Lord J J Gowans, Jacqueline T Hecht, Anuj Mankad, Lina Moreno Uribe, Daryl A Scott, Gary M Shaw, Mary Ann Thomas, Seth M Weinberg, Eric C Liao, Harrison Brand, Mary L Marazita, Robert J Lipinski, Jeffrey C Murray, Robert A Cornell, Elizabeth J Leslie-Clarkson

Faculty, Staff and Student Publications

Van der Woude syndrome (VWS) is an autosomal dominant disorder characterized by lower lip pits and orofacial clefts (OFCs). With a prevalence of ∼1 in 35,000 live births, it is the most common form of syndromic clefting. Most VWS is attributed to variants in IRF6 (∼70%) or GRHL3 (∼5%), leaving up to 25% of individuals without a molecular diagnosis. Both IRF6 and GRHL3 function in a transcriptional regulatory network (TRN) governing differentiation of periderm, a single epithelial cell layer preventing pathological adhesions during palatogenesis. Periderm disruption can elicit a spectrum of phenotypes, including lip pits and OFCs, pterygia, and severe …

Preclinical Models Of Melanoma Leptomeningeal Disease To Assess Intrathecal Checkpoint Blockade, Renato A Guerrieri, Grant M Fischer, Jacob R Cortez, Barbara G Knighton, Debora A Ledesma, Courtney W Hudgens, Yimmy F Delcid, Qianghua Hu, Christian Y B Onana, Fernando C L Carapeto, Michael T Tezlaff, Jason T Huse, Patrick Hwu, Elizabeth M Burton, Isabella C Glitza Oliva, Michael A Davies, Sherise D Ferguson

Faculty, Staff and Student Publications

Leptomeningeal disease (LMD) is a subtype of central nervous system metastatic disease that is associated with poor patient outcomes and limited treatment options. There is an unmet need to develop preclinical models of LMD to expedite and improve the development of new therapeutics. Here, we describe the development of multiple orthotopic immunocompetent murine models of melanoma LMD, including their use to assess the efficacy of systemic and/or intrathecal immunotherapy. LMD was established by direct intrathecal injection of murine cell lines (B16-F10, BP, D4M, D4M-UV2, MC38-gp100, RMS, YUMM3.1, and YUMMER1.7) into the cisterna magna of C57BL/6 mice. Tumor take rate, distribution, …

Long-Term Outcomes In Flt3-Mutated Acute Myeloid Leukemia After Frontline Hypomethylating Agent, Venetoclax And A Flt3 Inhibitor, Nicholas J Short, Sanam Loghavi, Musa Yilmaz, Omer Karrar, Kunhwa Kim, Courtney D Dinardo, Tapan M Kadia, Manuel Maroun, Gautam Borthakur, Ghayas C Issa, Joseph Jabbour, Betul Oran, Elizabeth J Shpall, Uday Popat, Keyur P Patel, Mark Routbort, Marina Konopleva, Farhad Ravandi, Hagop Kantarjian, Naval Daver

Faculty, Staff and Student Publications

Triplet regimens with a hypomethylating agent, venetoclax and a FLT3 inhibitor yield high rates of response in newly diagnosed FLT3-mutated AML. However, the long-term outcomes and patterns of relapse with these triplet regimens are not well-established. In this retrospective analysis, 73 patients with newly diagnosed FLT3-mutated AML received a frontline FLT3 inhibitor-containing triplet regimen. The composite complete remission (CR) and CR with incomplete hematologic recovery (CRi) rate was 93%. Next-generation sequencing FLT3-ITD MRD negativity (sensitivity: 0.005%) was achieved in 60% of patients after cycle 2 and 90% after cycle 4. The estimated 3-year relapse-free survival (RFS) for FLT3-ITD-mutated and FLT3 …

Reversible Arginine Methylation Of Pi3kc2Α Controls Mitotic Spindle Dynamics, Yena Cho, Jee Won Hwang, Mark T Bedford, Dong Hee Na, Dae-Geun Song, Su-Nam Kim, Yong Kee Kim

Faculty, Staff and Student Publications

Microtubules, composed of αβ-tubulin dimers, undergo dynamic polymerization and are fundamental to cell structure and function. In the current study, we discovered that phosphatidylinositol 3-kinase class 2α (PI3KC2α) acts as a novel regulatory factor in microtubule dynamics. Specifically, asymmetric dimethylation of PI3KC2α at the R175 residue (R175me2a) by coactivator-associated arginine methyltransferase 1 (CARM1) enhances its interaction with α-tubulin, stabilizing microtubule assembly. Furthermore, lysine Demethylase 4 A (KDM4A) serves as an arginine demethylase for PI3KC2α R175me2a. During mitosis, protein kinase C (PKC)-mediated phosphorylation of KDM4A results in its dissociation from PI3KC2α, preventing demethylation and increasing R175me2a levels. This facilitates spindle formation …

Kenyon Collegian - October 2, 2025

The Kenyon Collegian

No abstract provided.

Functional Effects Of Heavy Metal Exposures On N6-Methyladenosine (M6a) Methylation And Other Epitranscriptomic Modifications In The Central Nervous System, Niraj Lodhi, Lauren Powell, Jay S. Schneider

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Among different RNA methylations, N6-methyladenosine (m6A) is the most abundant in the brain and determines the fate of RNA through reversible processes using methyltransferases, demethylases, and methyl-binding proteins. The reversibility of m6A is an emerging regulatory mechanism for gene expression, regulating many aspects of RNA metabolism and influencing learning and memory processes. Global m6A profiles are dynamically modified via the activity of various writers, readers, and erasers. However, m6A alterations from exposure to heavy metals, including the metals lead (Pb), cadmium (Cd), cobalt (Co), and manganese (Mn) and the metalloid arsenic (As), and the impact on brain function, are not …

October 2, 2025, James Madison University

The Breeze, 2020-

The Breeze is the student newspaper of James Madison University in Harrisonburg, Virginia.

Evaluating Anti-Sickling Therapies For Sickle Cell Disease: A Microfluidic Assay For Red Blood Cell-Mediated Microvascular Occlusion Under Hypoxia, Zoe Sekyonda, Yuxuan Du, Solomon Oshabaheebwa, Payam Fadaei, Yusang B. Ley, Calvin Abonga, Michael A. Suster, Pedram Mohseni, Umut A. Gurkan

Faculty Scholarship

Sickle cell disease (SCD) is characterized by the polymerization of hemoglobin S (HbS) upon deoxygenation, leading to the formation of sickled red blood cells (RBCs) with reduced deformability. Under hypoxic conditions, the impaired RBC behavior significantly contributes to vaso-occlusive events, hemolysis, and end-organ damage. Consequently, RBC deformability serves as a pivotal hemorheological biomarker for evaluating disease severity and therapeutic response. The OcclusionChip, a microfluidic assay, measures RBCs deformability through microcapillary occlusion. However, its current hypoxic assay relies on a complex nitrogen gas setup, rendering it bulky, expensive, and unsuitable for point-of-care diagnostic use. Here, we optimized a chemically induced hypoxia …

October 2, 2025, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

A Needed Nomenclature For Nucleosomes, Michael-Christopher Keogh, Genevieve Almouzni, Andrew J Andrews, Karim-Jean Armache, Cheryl H Arrowsmith, Sung Hee Baek, Mark T Bedford, Emily Bernstein, Jacques Côté, Yael David, John M Denu, Beat Fierz, Benjamin A Garcia, Karen C Glass, Or Gozani, Kristian Helin, Steven Henikoff, Ole N Jensen, Steven Z Josefowicz, Neil L Kelleher, Tatiana G Kutateladze, Herbert H Lindner, Chao Lu, Karolin Luger, Parag Mallick, Catherine A Musselman, Tom W Muir, Ljiljana Paša-Tolić, Robert Schneider, Xiaobing Shi, Yang Shi, Simone Sidoli, Lloyd M Smith, Jessica K Tyler, Cynthia Wolberger, Jerry L Workman, Brian D Strahl, Nicolas L Young

Faculty, Staff and Student Publications

Histone post-translational modifications (PTMs) are crucial to eukaryotic genome regulation, with a range of reported functions and mechanisms of action. Though often studied individually, it has long been recognized that the modifications function by combinatorial synergy or antagonism. Interplay may involve PTMs on the same histone, within the same nucleosome (containing a histone octamer), or between nucleosomes in higher-order chromatin. Given this, the field must distinguish ever greater complexity, and the context in which it is studied, with brevity and precision. The proteoform was introduced to define individual forms of a protein by sequence and PTMs, followed by the nucleoform …

Forage Sampling Guide For Agronomic Crops, Jody Gale, Matt Yost, Megan Baker, Michael Pace, Earl Creech, Grant Cardon, Kalen Taylor, Cody Zesiger, Tiffany Evans, Rhonda Miller, Clara Anderson

All Current Publications

Forage sampling is a valuable tool that provides producers with quality information for calculating feed rations and marketing their forages. To ensure that this information is accurate and reliable, it is important to understand how to collect these samples correctly. Sampling tools have been developed that simplify this process and improve accuracy.

Factors Influencing Employee Green Behavior And Employee Green Attitude Among Muslims In Indonesia, Kurnia Sari Kasmiarno, Mahjus Ekananda, Gina Destrianti Karmanto

Journal of Environmental Science and Sustainable Development

In a Muslim majority, developing country like Indonesia, religion shapes employees’ work ethic and professional behavior, embedding spiritual and cultural values into the workplace. Despite the increasing attention to pro-environmental behavior, previous studies have largely examined Green Human Resource Management (GHRM), religiosity, and environmental concern separately, often focusing on a single sector. This leaves employees from various occupational backgrounds underexplored. This study aims to examine the effects of Green Concern (GC), Green Motivation (M), GHRM, and Religiosity (REL) on Employee Green Behavior (EGB) and Employee Green Attitude (EGA) of Muslim employees in Indonesia. Data were collected through a quantitative survey …

Green Human Resource Management, Employee Behavior, And Organizational Innovation: A Multi-Theoretic Pathway To Sustainable Competitiveness, Iwan Perwira, Hernita Hernita, Suardi Suardi, Andi Tenry Sose, Muhammad Azizurrohman

Journal of Environmental Science and Sustainable Development

As sustainability imperatives reshape global tourism, this study investigates how Green Human Resource Management (GHRM) practices can serve as strategic levers for driving sustainability performance and competitive advantage within Indonesia’s tourism sector. Amid rising environmental expectations and regulatory mandates, the research integrates Social Learning Theory, the Resource-Based View, and Institutional Theory to construct and test a model that links top management support, green organizational culture, and regulatory pressure to GHRM adoption. Using a cross-sectional survey of 510 employees and managers across eco-certified tourism firms in five Indonesian destinations, the study employed Partial Least Squares Structural Equation Modeling (PLS-SEM) to analyze …

Implications Of Electric Vehicles Use On Value Co-Creation And Improving Community Welfare, Rastinia Kamila Hanum, Rizal Edy Halim

Journal of Environmental Science and Sustainable Development

Transportation is closely related and to support daily community mobility, 90% of road transportation operates on fossil fuel and it has always been accompanied by new innovations. Electric vehicles are predicted to be the future transportation to reduce greenhouse emissions. This study combines theories on behavioral and technology acceptance to create value co-creation and enhance community well-being. This quantitative study surveyed 210 respondents from the target community especially in Java island, who intend to adopt electric vehicles (EVs) using Google Form. PLS-SEM was used to evaluate research framework which integrates TPB, Technology Acceptance Model (TAM), and Unified Theory of Acceptance …

Montana Kaimin, October 2, 2025, Students Of The University Of Montana, Missoula

Montana Kaimin, 1898-present

Student newspaper of the University of Montana, Missoula.

Dandy-Walker Malformation And Optic Nerve Hypoplasia: A Developmental Case Highlighting The Psychiatric Impact Of Central Nervous System Malformation, Sumeet Bhardwaj, Aayush Kapoor, Yuan Xie, Ali Thahab, Affan Naveed, Omer Khan, Thinh D. Mai

Student Publications

Dandy-Walker malformation (DWM) and optic nerve hypoplasia (ONH) are rare congenital anomalies associated with neuropsychiatric morbidity, but their co-occurrence in adults has not been described. We present an adult patient with both DWM and unilateral ONH who developed auditory hypersensitivity, visual agnosia, phonological dyslexia, dysgraphia, and longstanding academic challenges, later evolving into recurrent depression, anxiety, and insomnia. Neuroimaging revealed a Dandy-Walker variant with cerebellar atrophy and ONH, and her presentation was consistent with cerebellar cognitive affective syndrome. Notably, despite the established risk of autism spectrum-like traits in both DWM and ONH, she did not demonstrate autistic features. This case highlights …

Characterizing Meteorological Patterns For Oregon's Winter Elevated Pm2.5 Concentrations From 2000-2023, Arielle Golda Sherbak

Dissertations and Theses

Valleys and basins are uniquely susceptible to the buildup of air pollution during the wintertime due to cool, dense air pooling under favorable meteorological conditions, a common occurrence in the Intermountain West. In Oregon, wintertime anthropogenic air pollution is primarily from woodburning stoves and heaters and although efforts have been made to reduce wintertime pollution, stagnation events continue to result in decreased air quality. This analysis aims to understand the relationship between air pollution in six Oregon counties and the associated meteorology in the cool season (November-March) using a 2000-2023 climatology.

This is completed through a composite analysis using key …

Effect Of Establishing A Separate Outpatient Pharmacy Counter On Reducing Waiting Time In Mayapada Hospital, Hanifan Irham, Masyitoh Basabih

Jurnal ARSI : Administrasi Rumah Sakit Indonesia

Pharmacy waiting time is one of the quality indicators that affects patient satisfaction in hospitals. One of the various efforts to reduce drug waiting times is adding outpatient pharmacies. This study aims to see whether the addition of pharmacies based on guarantors can reduce drug waiting times for outpatients. This is an observational study with a cross-sectional design. The sample included 11,703 patients who received prescriptions at Mayapada Hospital Bogor outpatient with insurance and private coverage. Data were collected over four months, two months before and two months after the separation of pharmacies. Waiting time data were obtained from the …