Digital Commons Network^™

Indiana At A Glance: County Trends, 2025 Edition, Roberto Gallardo

Purdue University Press Books

Indiana at a Glance: County Trends, 2025 Edition provides an overview of macro socioeconomic and demographic trends based on county-level data in ten-year periods in Indiana, the upper Midwest region, and the nation. Analyzing data primarily from 2013 through 2023, this book presents information that contextualizes the design and implementation of specific policies enacted by elected officials and community leaders, and reveals the impact these initiatives have on the public.

Inspired, in part, by the United States Department of Agriculture’s Rural America at a Glance reports, as well as the author’s more than twenty years of work in the field, …

Graphrag-Enabled Local Large Language Model For Gestational Diabetes Mellitus: Development Of A Proof-Of-Concept, Edmund Evangelista, Fathima Ruba, Salman Bukhari, Amril Nazir, Ravishankar Sharma

All Works

Background: Gestational diabetes mellitus (GDM) is a prevalent chronic condition that affects maternal and fetal health outcomes worldwide, increasingly in underserved populations. While generative artificial intelligence (AI) and large language models (LLMs) have shown promise in health care, their application in GDM management remains underexplored. Objective: This study aimed to investigate whether retrieval-augmented generation techniques, when combined with knowledge graphs (KGs), could improve the contextual relevance and accuracy of AI-driven clinical decision support. For this, we developed and validated a graph-based retrieval-augmented generation (GraphRAG)–enabled local LLM as a clinical support tool for GDM management, assessing its performance against open-source LLM …

Role Of M6a Mrna Methylation In Plant Defense, Rakesh Srivastava, Niraj Lodhi

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

N6-methyladenosine (m⁶A) is the most abundant and dynamic RNA modification in eukaryotic messenger and non-coding RNAs, playing a pivotal role in the post-transcriptional regulation of gene expression. The coordinated actions of m⁶A writers, erasers, and readers influence transcript stability, immune activation, and pathogen suppression. Growing evidence indicates that m⁶A fine-tunes the expression of defense-related genes, modulates RNA processing events, and is frequently hijacked by pathogens and pests to promote virulence. Notably, the dual role of m⁶A in enhancing plant defense and facilitating pathogen adaptation highlights its significance in the host–pathogen arms race. …

Finessing A Medical Expert’S Qualifications: From Professional Communities’ Boundaries To Personal Character, Patrick Garon-Sayegh

Osgoode Hall Law Journal

This article examines the kinds of arguments that can be made in debates regarding whether or not an expert is properly qualified to critique the work or opinions of another expert. Since these debates routinely occur in both legal and political arenas, a more fine-tuned sense of their argumentative dynamics can be fruitful for reasoning through them. This article is built around the analysis of a decision which concerned the admissibility of a physician’s testimony on the medical standard of care in a malpractice case. A detailed parsing of the arguments in that decision lays the groundwork for a theoretical …

Against Settlement In Transnational Business And Human Rights Litigation, Hassan M. Ahmad

Osgoode Hall Law Journal

In “Against Settlement,” Owen Fiss argued that settlement may not always be the optimal result of civil suits, particularly those that involve novel or ambiguous areas of law or ostensible power imbalances. That work spurred a range of scholarship around the merits and demerits of settlement. And although the settlement versus litigation debate is now almost four decades old, its currency persists in common law systems in which courts are, at times, called upon to expand or even re-envision doctrines or procedural rules. This article revisits that debate. It applies “Against Settlement” to transnational business and human rights litigation that …

Crim-Eviction: Eviction And Social Control At A Residential Tenancies Tribunal, Sarah Buhler

Osgoode Hall Law Journal

Because eviction from rental housing can lead to highly negative outcomes, including homelessness, trauma, neighbourhood instability, and deepening inequities, it is important to understand the reasoning processes employed by tribunals when they wield the power of eviction. This article conducts a critical reading of decisions of the Office of Residential Tenancies, Saskatchewan’s residential tenancies tribunal, that deal specifically with urgent landlord applications for immediate eviction based on tenant behaviours that are alleged to be criminal, illegal, frightening, or dangerous. Coining the term “crim-eviction” to help describe this category of decisions, the article identifies that residential tenancies tribunals like the Office …

Sex Discrimination, Assimilation, And Austerity: The Untold Story Of Canada’S Indian Act, 1975-1985, Genevieve Renard Painter

Osgoode Hall Law Journal

This article is about the misunderstood history of a Canadian law for determining Indian status, the decades-long struggle to remedy sex discrimination in the law, and the significance of judges writing history. Since before Canada’s confederation until amendments to the Indian Act in 1985, Indian women, unlike Indian men, lost their Indian status if they married non-Indians. Even with the 1985 amendments, the law still disadvantaged people who traced their Indian status along the female line. Facing a challenge to the law based on sex discrimination, the government argued that the enduring disadvantage to women was the only way to …

Predictors Of Long-Term Follow-Up Clinic Attendance And Continued Engagement Among Survivors Of Cancer In Childhood And Adolescence, Ji Yun Tark, Kayla L Foster, Shawki L Qasim, Omar Shakeel, Alicia Howell, Mary C Shapiro, Abiodun Oluyomi, Zoann E Dreyer, Ashley M Butler, Austin L Brown, Maria M Gramatges

Faculty, Staff and Students Publications

Purpose: Survivorship care is vital to screen for and manage late effects, yet follow-up remains suboptimal. We examined factors associated with long-term survivor clinic (LTSC) nonattendance, delayed initiation, and disengagement at a large, diverse pediatric cancer center.

Methods: We analyzed outcomes in 1138 survivorship-eligible childhood cancer survivors diagnosed between 2011 and 2019. Outcomes included (1) LTSC nonattendance (no visit ≥ 2 years post-treatment), (2) delayed LTSC visit initiation (first visit > 5 years from end of treatment), and (3) LTSC visit disengagement (no follow-up after initial LTSC visit). Adjusted odds ratios (aORs) and 95% confidence intervals (CIs) for factors associated with …

Rehabilitation For Chronic Neurological Disorders Including Acquired Brain Injury: Information For The Public, Ian Bernstein, Rachel Keetley, Emer Gilloway, Parashar Ramanuj, Jane Williams, Jenny Jim, Hamise Smith, Nassif Mansour, Rachel Farrell, Gabrielle Parker, Joanne Powell, Jacqueline Dean, Jill Kings, Teresa Clark, Lisa Bunn, Mark Holloway, Nicholas Behn, Geraldine Roxburgh, Sue Williams, Yvonne Pettigrew, Caroline Jones, Lisa Boardman, Jen Francis, Alice Navein, Hayley Shaw, Eric Slade, Joanna Perkin, Kelly Williams, Anja Fricke, Gareth Haman

School of Health Professions

No abstract provided.

Differential Bk Channel Potentiation By Vanzacaftor Enantiomers Enables Therapy For Modulator-Ineligible People With Cystic Fibrosis, Nathalie Baumlin, Sumedha Gunewardena, Scott H Randell, Frank T Horrigan, Matthias Salathe

Faculty, Staff and Students Publications

No abstract provided.

Sub-Ciliary Localization Of Cep290 And Effects Of Its Loss In Mouse Photoreceptors During Development, Abigail R. Moye, Michael A. Robichaux, Melina A. Agosto, Alexandre P. Moulin, Alexandra Graff-Meyer, Carlo Rivolta, Theodore G. Wensel

Faculty, Staff and Students Publications

No abstract provided.

Alterations Of The Upper Respiratory Microbiome Among Children Living With Hiv Infection In Botswana, Sweta M Patel, John Farirai, Mohamed Z Patel, Sifelane Boiditswe, Leabaneng Tawe, Shimane Lekalake, Mogomotsi Matshaba, Andrew P Steenhoff, Tonya Arscott-Mills, Kristen A Feemster, Samir S Shah, Nathan Thielman, Coleen K Cunningham, Lawrence A David, David M Murdoch, Matthew S Kelly

Faculty, Staff and Students Publications

Children living with HIV (CLWH) are at high risk of colonization and infection by respiratory pathogens, though this risk can be reduced by other microbes in the upper respiratory microbiome. The impact of HIV infection on the pediatric upper respiratory microbiome is poorly understood, and we sought to address this knowledge gap by identifying associations between HIV infection and the nasopharyngeal microbiomes of Batswana children. We enrolled Batswana CLWH (< 5 years) and age- and sex-matched HIV-exposed, uninfected and HIV-unexposed, uninfected children in a cross-sectional study. We used shotgun metagenomic sequencing to compare nasopharyngeal microbiomes by HIV status. Among the 143 children in this study, HIV and HIV-associated immunosuppression were associated with alterations in nasopharyngeal microbiome composition, including lower abundances of Corynebacterium species associated with resistance to bacterial pathogen colonization. These findings suggest that the upper respiratory microbiome may contribute to the high risk of respiratory infections among CLWH.

Resilience And Vulnerabilities Of Tumor Cells Under Purine Shortage Stress, Jianpeng Yu, Chen Jin, Cheng Su, David Moon, Michael A Sun, Hong Zhang, Xue Jiang, Fan Zhang, Nomi Tserentsoodol, Michelle L Bowie, Christopher J Pirozzi, Daniel J George, Robert Wild, Xia Gao, David M Ashley, Yiping He, Jiaoti Huang

Faculty, Staff and Students Publications

Purpose: Purine metabolism is a promising therapeutic target in cancer; however, how cancer cells respond to purine shortage, particularly their adaptation and vulnerabilities, remains unclear.

Experimental design: Using the recently developed purine shortage-inducing prodrug DRP-104 and genetic approaches, we investigated the responses in prostate, lung, and glioma cancer models.

Results: We demonstrate that when de novo purine biosynthesis is compromised, cancer cells employ microtubules to assemble purinosomes, multiprotein complexes of de novo purine biosynthesis enzymes that enhance purine biosynthesis efficiency. Although this process enables tumor cells to adapt to purine shortage stress, it also renders them more susceptible to the …

Stereoelectroencephalography Reveals Neural Signatures Of Multisensory Integration In The Human Superior Temporal Sulcus During Audiovisual Speech Perception, Yue Zhang, John F Magnotti, Xiang Zhang, Zhengjia Wang, Yingjia Yu, Kathryn A Davis, Sameer A Sheth, H Isaac Chen, Daniel Yoshor, Michael S Beauchamp

Faculty, Staff and Students Publications

Human speech perception is multisensory, integrating auditory information from the talker's voice with visual information from the talker's face. BOLD fMRI studies have implicated the superior temporal gyrus (STG) in processing auditory speech and the superior temporal sulcus (STS) in integrating auditory and visual speech, but as an indirect hemodynamic measure, fMRI is limited in its ability to track the rapid neural computations underlying speech perception. Using stereoelectroencephalography (sEEG) electrodes, we directly recorded from the STG and STS in 42 epilepsy patients (25F, 17M). Participants identified single words presented in auditory, visual, and audiovisual formats with and without added auditory …

Tulp3 Quantitative Alleles Titrate Requirements For Viability, Brain Development, And Kidney Homeostasis But Do Not Suppress Zfp423 Mutations In Mice, Corinne A. Mccoy, Dorothy Concepcion, Mark G. Mezody, Raquel Lara, Ojas Deshpande, Catherine Liang, Renee Long, Bruce A. Hamilton

School of Medicine Publications

Tubby-like protein 3 (TULP3) regulates receptor trafficking in primary cilia and antagonizes SHH signaling. Tulp3 knockout mice are embryonic lethal with developmental abnormalities in multiple organs, while tissue-specific knockouts and viable missense alleles cause polycystic kidney disease. Human patients with TULP3 mutations present with variable, but often multi-organ fibrotic disease. We previously showed that mouse and human Tulp3 expression is negatively regulated by ZNF423, which is required for SHH sensitivity in some progenitor cell models. The level of TULP3 function required to prevent mutant phenotypes has not been known. Here we report a Tulp3 quantitative allelic series, designed …

Percutaneous Thromboaspiration Of Left Main Coronary Artery Vegetation In A Patient With Aortic Valve Infective Endocarditis And Acute Coronary Syndrome, Matthew B Morton, Jeremy Russo, Malanka Lankaputhra, Christopher Merry, Dion Stub

Journal of the Saudi Heart Association

Acute myocardial infarction from a vegetation is a rare complication of infective endocarditis. Thrombolysis, percutaneous coronary intervention with balloon angioplasty, stenting, and thromboaspiration, and surgery have all been described in this challenging clinical scenario. A woman with staphylococcal bioprosthetic aortic valve infective endocarditis developed acute myocardial infarction due to a vegetation invading the left main coronary artery, which was successfully managed with percutaneous thromboaspiration.

Hannah Webster Foster And Benjamin Franklin: Addressing The Coquette Through The Male And Female Voice, Gianna Vaynberg

Locus: The Seton Hall Journal of Undergraduate Research

Throughout history, women have carried the weight of social expectations that have been thrust upon them by a patriarchal society, within which men are not held to nearly the same moral standard and scrutiny. This is reflected in both Benjamin Franklin’s and Hannah Webster Foster’s tales of a “coquette” damned by society for becoming pregnant outside of marriage. However, each of these narratives presents readers with a unique picture of a “coquette.” Both “The Speech of Miss Polly Baker” and The Coquette provide criticisms about the archetype of the coquette. However, while The Coquette presents a cautionary tale dissuading young …

Morality Of Medieval Magic In Medicine, Jacob Mudd

Locus: The Seton Hall Journal of Undergraduate Research

In the late medieval and early Renaissance eras, attitudes towards science, religion, and magic were in upheaval. The Reformation was heavily critiquing Catholicism as being too closely related to magic, there were pushes for leaving long-held beliefs behind in favor of newer science, and society as a whole was in a massive period of change. One of the places all three topics intersect is medicine. Normal medicine during this period was often ineffective, furthering the need for people seek out magical cures, which were in turn often intertwined with religion. By looking at the question of whether it would have …

Cybersecurity In Donald Trump’S 2024 Presidential Election Campaign, Julia Celestino

Locus: The Seton Hall Journal of Undergraduate Research

Cybersecurity is of growing importance in America today, yet discussion about cybersecurity in Trump’s 2024 election campaign was limited. This paper discusses how the role of cybersecurity in Donald Trump’s 2024 election campaign was limited by cybersecurity issues from his first term which continue to damage public support for his campaign, the unpopularity of cybersecurity among voters, and an effort to encourage collaboration with technology companies. Focus is on a timeframe from November 15, 2022 to April 30, 2025 (the date Donald Trump announced his candidacy to his 100th day in office). Ultimately, cybersecurity issues see more policy outcomes when …

Behavioral Inhibition And Cognitive Control In An Emotional Go/No-Go Task, Amanda Burns

Locus: The Seton Hall Journal of Undergraduate Research

Behavioral inhibition is a temperamental tendency associated with heightened risk for developing anxiety disorders. Individuals with behaviorally inhibited temperament tend to avoid or withdraw from novel situations, which may be associated with prefrontal cortical activation related to cognitive control. The purpose of this study is to investigate how behavioral inhibition influences cognitive control using an emotional Go/No-go task. Participants completed the State-Trait Anxiety Inventory (STAI-Y) which assesses feelings of anxiousness, and the Adult Measure of Behavioral Inhibition, which measures behaviorally inhibited temperament. Participants then completed an emotional Go/No-go task utilizing neutral and negative stimuli and asking participants to quickly respond …

The Isolation And Dna Extraction Of Phytophthora From Four Wildland Soil Types In Northern California, Humboldt County, Angelina Lasko, Christopher Lee, David S. Baston, Susan E. Marshall

Creative Publications and Manuals

Phytophthora species are of global importance (Sinclair and Lyon, 2005). For most Phytophthora species, the natural mechanism of how these pathogens travel and spread long distances is not fully understood. They are have been shown to travel by air, water, nursery stock, and via inadvertent human transport. The purpose of this study was to identify the presence of Phytophthora species in four different Northern California forest/wildland soil types. Soils from Franciscan complex parent material (riparian, mixed conifer, and oak woodland), and serpentine parent material (mixed conifer) were sampled in Humboldt County (Fig 1). Phytophthora and other pathogens were baited from …

Microclimatic Conditions In Shulgan-Tash Cave (Southern Ural, Russia): Implications For The Preservation Of Eastern Europe’S Largest Paleolithic Art Collection, Olga Chervyatsova, Rayan Akhmedyanovb, Nailya Saifullina, Ludmila Kuzmina, Mihael Kotov, Yuri Dublyansky

International Journal of Speleology

This study presents the results of a long-term investigation of the microclimatic conditions in Shulgan-Tash Cave (Southern Urals, Russia), which hosts the largest assemblage of Upper Paleolithic paintings (ca. 16.3–19.6 ka) in Eastern Europe. The cave exhibits two distinct seasonal ventilation regimes – winter and summer – differentially influence its two levels of galleries. In the Lower Level, which contains 83% of the images, near-atmospheric CO₂ concentrations persist year-round, and temperature variations associated with seasonal infiltration events are minimal (1.0–1.3°C). By contrast, the Upper Level, including the decorated Hall of Paintings, is affected by downdrafts of CO₂-rich …

J Am Coll Dent 2024 91 3

Journal of the American College of Dentists

The Journal of the American College of Dentists (JACD) publishes scholarly articles, editorials, essays, and reflections addressing the ethical, professional, and social dimensions of dentistry. The Journal serves as a forum for advancing ethics, professionalism, leadership, and excellence within the dental community. By fostering dialogue across disciplines and perspectives, JACD provides readers with insights that encourage ethical, professional practice, lifelong learning, and service to the public, reinforcing dentistry’s commitment to advancing oral healthcare and the common good.

J Am Coll Dent 2024 91 2

Journal of the American College of Dentists

The Journal of the American College of Dentists (JACD) publishes scholarly articles, editorials, essays, and reflections addressing the ethical, professional, and social dimensions of dentistry. The Journal serves as a forum for advancing ethics, professionalism, leadership, and excellence within the dental community. By fostering dialogue across disciplines and perspectives, JACD provides readers with insights that encourage ethical, professional practice, lifelong learning, and service to the public, reinforcing dentistry’s commitment to advancing oral healthcare and the common good.

J Am Coll Dent 2024 91 1

Journal of the American College of Dentists

The Journal of the American College of Dentists (JACD) publishes scholarly articles, editorials, essays, and reflections addressing the ethical, professional, and social dimensions of dentistry. The Journal serves as a forum for advancing ethics, professionalism, leadership, and excellence within the dental community. By fostering dialogue across disciplines and perspectives, JACD provides readers with insights that encourage ethical, professional practice, lifelong learning, and service to the public, reinforcing dentistry’s commitment to advancing oral healthcare and the common good.

J Am Coll Dent 2023 90 4

Journal of the American College of Dentists

The Journal of the American College of Dentists (JACD) publishes scholarly articles, editorials, essays, and reflections addressing the ethical, professional, and social dimensions of dentistry. The Journal serves as a forum for advancing ethics, professionalism, leadership, and excellence within the dental community. By fostering dialogue across disciplines and perspectives, JACD provides readers with insights that encourage ethical, professional practice, lifelong learning, and service to the public, reinforcing dentistry’s commitment to advancing oral healthcare and the common good.

J Am Coll Dent 2023 90 3

Journal of the American College of Dentists

The Journal of the American College of Dentists (JACD) publishes scholarly articles, editorials, essays, and reflections addressing the ethical, professional, and social dimensions of dentistry. The Journal serves as a forum for advancing ethics, professionalism, leadership, and excellence within the dental community. By fostering dialogue across disciplines and perspectives, JACD provides readers with insights that encourage ethical, professional practice, lifelong learning, and service to the public, reinforcing dentistry’s commitment to advancing oral healthcare and the common good.

J Am Coll Dent 2023 90 2

Journal of the American College of Dentists

The Journal of the American College of Dentists (JACD) publishes scholarly articles, editorials, essays, and reflections addressing the ethical, professional, and social dimensions of dentistry. The Journal serves as a forum for advancing ethics, professionalism, leadership, and excellence within the dental community. By fostering dialogue across disciplines and perspectives, JACD provides readers with insights that encourage ethical, professional practice, lifelong learning, and service to the public, reinforcing dentistry’s commitment to advancing oral healthcare and the common good.

J Am Coll Dent 2023 90 1

Journal of the American College of Dentists

The Journal of the American College of Dentists (JACD) publishes scholarly articles, editorials, essays, and reflections addressing the ethical, professional, and social dimensions of dentistry. The Journal serves as a forum for advancing ethics, professionalism, leadership, and excellence within the dental community. By fostering dialogue across disciplines and perspectives, JACD provides readers with insights that encourage ethical, professional practice, lifelong learning, and service to the public, reinforcing dentistry’s commitment to advancing oral healthcare and the common good.

Ethical Care Is Excellent Care: Exploring How Dentists Can Approach Treating Visually Impaired Patients Through Different Ethical Frameworks, Elizabeth Gershater

Journal of the American College of Dentists

The Ozar-Hasegawa Annual Student Ethics Award recognizes an outstanding scholarly submission in dental ethics, published annually in the Journal of the American College of Dentists (JACD). This article highlights the winning work, selected for its significant contribution to advancing ethical reflection and professional responsibility in dentistry.