Digital Commons Network^™

Correcting For The Inflated Adult Population Denominator In An English Nationwide Health Care Cohort: Database Analysis Study, Sudhir Venkatesan, Mark Joy, Gavin Jamie, Debasish Kar, Robert Williams, Xuejuan Fan, Wilhelmine Meeraus, Ruby S.M. Tsang, Kathryn S. Taylor, Sylvia Taylor, F. D. Richard Hobbs, Sneha N. Anand, Chris Robertson, Simon De Lusignan

Peninsula Medical School

Background:Electronic health care databases are widely used for epidemiological studies. However, they may contain inactive records of individuals no longer participating in the health care system. These inactive records create a methodological challenge as they systematically appear as unexposed with no recorded outcomes. Given the widespread health care system engagement during the COVID-19 pandemic, the English National Health Service (NHS), which hosts a national pandemic planning and research dataset with linkage to COVID-19 vaccination and emergency care data, makes it an ideal setting to identify the extent of overrepresentation due to inactive health care records and assess ways to mitigate …

Targeting Gliomas With Beta-Amyloid-Specific Dyes: A Novel Approach For In Vivo Staining And Potential Therapeutic Applications, Lilia Kucheryavykh, Jescelica Ortiz Rivera, Boris Ermolinsky, Vassiliy Tsytsarev, Lynnette Cary, Janaina Alves, Adriana Reyes, Noelis De La Cruz-Rivera, Kevin Rosa Gonzalez, Felix Narvaez Irizarry

School of Integrative Biological & Chemical Sciences Faculty Publications

Gliomas, the most common primary brain tumors, present significant diagnostic and treatment challenges due to their infiltrative nature and heterogeneity. Our previous research revealed that glioma tumors in both animals and humans accumulate beta-amyloid protein (Aβ), detectable through immunohistochemical methods or staining with amyloid-specific dyes. We hypothesize that beta-amyloid-specific dyes could serve as glioma markers, potentially enabling the delineation of glioma tumors or targeted therapeutics delivery. In this study, the specificity and blood-brain barrier permeability of two fluorescent beta-amyloid-specific dyes, Brilliant Blue G (BBG) and BODIPY-based Amyloid Probe-1 (BAP-1), were evaluated in C57Bl/6 mouse glioma implantation models using GL261 and …

How Sociologist Paul F. Lazarsfeld Became An Influencer: 80 Years Of Opinion Leader Research, Amelie Duckwitz, Hermann Strasser

Sociology Between the Gaps: Forgotten and Neglected Topics

No abstract provided.

Surface Roughness And Microbial Adhesion On Four Provisional Prosthodontic Restorative Materials, Ola Al Hatem, Joe C Ontiveros, Donald M Belles, Maria D Gonzalez, Ransome Van Der Hoeven

Faculty, Staff and Student Publications

No abstract provided.

Evaluating Response Calculation Methods For Thin And Volume Analog Holographic Wavefront Sensors, Emma Branigan, Andrew Lambert, Andreas Zepp, Szymon Gladysz, Suzanne Martin, Matthew Sheehan, Kevin Murphy

Research Outputs: 2025-Present

The modal analog holographic wavefront sensor (AHWFS) is a low-cost and high-speed solution for wavefront sensing. It uses a phase biasing approach, where a pair of holograms are biased with a known phase delay/advance. The aberration magnitude is determined by measuring the diffracted beam intensities from the hologram pair. Both thin and volume phase transmission holograms can be used. Thin gratings produce multiple diffracted orders, while volume gratings direct light into a single order. Sensor response is measured using photodiodes or cameras, though thin holograms require a small region of interest for sensitivity to changing aberration magnitudes. This work compares …

Peritoneal Delivery Of Capsinoids, Nonpungent Trpv1 Agonists, Induces Mild Hypothermia In Conscious Mice Through Trpv1 Activation Of Visceral Vagal Afferents, Alexander P Andersohn, Ting Wu, Andrea N Doan, Charles L Cantrell, Robert L Jarret, Sean P Marrelli

Faculty, Staff and Student Publications

Therapeutic hypothermia (TH) has demonstrated neuroprotection in instances of cardiac arrest and neonatal hypoxia/ischemia but faces different challenges in application to stroke due to the activation of cold defense mechanisms in conscious patients. This study examined the efficacy and specificity of capsinoids (a purified mixture of capsiate and dihydrocapsiate) to induce a sustained fall in core body temperature in conscious mice. Capsinoids function as TRPV1 agonists. However, unlike capsaicin, capsinoids are vulnerable to esterase-mediated breakdown, thus significantly restricting their action to the site of delivery. We showed that capsinoids delivered intraperitoneally (IP) to mice induced a TRPV1-dependent drop in core …

Pharmacological Profiling In Cll Patients During Pirtobrutinib Therapy And Disease Progression, Shady I Tantawy, Burcu Aslan, Ganiraju Manyam, Lakesla R Iles, Natalia Timofeeva, Neetu Singh, Nitin Jain, Alessandra Ferrajoli, Philip A Thompson, Keyur P Patel, Sai Prasad Desikan, William G Wierda, Varsha Gandhi

Faculty, Staff and Student Publications

No abstract provided.

Pediatric Vs Adult Invasive Aspergillosis In Cancer And Hematopoietic Transplant Patients: Insights From A Matched Cohort At A Tertiary Cancer Center, Saliba Wehbe, Ramia Zakhour, Ray Hachem, Ying Jiang, Hiba Dagher, Roseen Salman, Anne-Marie Chaftari, Issam I Raad

Faculty, Staff and Student Publications

Background: Invasive aspergillosis (IA) is a life-threatening infection in immunocompromised patients, including those with hematologic malignancies and hematopoietic stem cell transplants. While adult IA has been well characterized, data on pediatric populations remain limited, and potential age-related differences are often overlooked in current management guidelines.

Methods: We conducted a retrospective matched cohort study at a tertiary cancer center, evaluating IA cases diagnosed over a 31-year period. Pediatric patients (≤18 years) with proven or probable IA were matched 1:3 with adult IA cases based on year of diagnosis, underlying disease, and history of hematopoietic cell transplantation. We compared demographics, clinical presentation, …

Evaluating Sustainability Research In Argentine Higher Education, María Belén Arias Valle, Frederic Marimon Dr.

Higher Learning Research Communications

This study analyzes the integration of sustainability into the research activities of Argentine higher education institutions (HEIs), both public and private. Through a quantitative approach, 132 HEIs were evaluated regarding the presence of sustainability research lines, the inclusion of this topic in strategic plans, and the existence of specialized institutes and academic publications. The results indicate that only 26% of HEIs have established research lines on sustainability, with greater participation from public universities. However, the overall commitment is uneven, with only 55% of institutions including sustainability in their strategic plans. The limited presence of observatories, specialized journals, and research centers …

The George-Anne Daily, Georgia Southern University

George-Anne Media Group: Newsletters & Magazines

No abstract provided.

The Volume And Characteristics Of Research On Gastrointestinal Symptoms In ‘Natural’ Peri- And Postmenopause:: A Scoping Review, Naomi Shaw, Rebecca Abbott, Clare Pettinger

School of Health Professions

BACKGROUND: Menopause has been linked to an array of symptoms, often with adverse effects on quality of life, work and relationships. Despite evidence of economic and social impacts, and a growing population of menopausal individuals, there are significant gaps in knowledge regarding menopause. Gastrointestinal (GI) symptoms in peri- and postmenopause are areas of uncertainty that warrant further investigation.

OBJECTIVES: Following JBI guidance, this scoping review aimed to systematically map research on GI symptoms in 'natural' peri- and postmenopause, exploring the volume and conduct of research, and variables investigated that could influence symptom experience.

ELIGIBILITY CRITERIA: Studies assessing GI symptoms (constipation, …

Perspectives On High-Value Care Education Among Us Medical Students, Hannah K. Bassett, Michelle Chen, Shivani Jain, Anitra Karthic, Karthik Ramesh, Hannah Shenton, September Wallingford, Allison Heacock

School of Medicine Faculty Publications

No abstract provided.

Cd5 Expression In Ctcl And Its Implications For Anti-Cd5 Car T-Cell Therapy, Leena Wardeh, Madeline Williams, Courtney Prestwood, Zachary Wolner, Neda Nikbakht

Department of Dermatology and Cutaneous Biology Faculty Papers

Cutaneous T-Cell Lymphomas (CTCL) are a heterogenous group of T-cell malignancies in the skin and have poor treatment outcomes in advanced stages. CD5, a surface glycoprotein expressed on most mature T cells, has emerged as a promising target for chimeric antigen receptor (CAR) T-cell therapy in systemic T-cell lymphomas. However, its expression profile in CTCL and relevance for targeted therapy remain unclear. Notably, in CTCL, the cell surface expression of receptors, such as CD7 and CD26, tends to become downregulated on the surfaces of malignant T cells In this study, we analyzed single-cell RNA sequencing (scRNA-seq) data from patients at …

A Novel Approach To Calculating Expected Total Fetal Lung Volume In Fetuses With Isolated Congenital Diaphragmatic Hernia And Fetal Growth Restriction: A Theoretical Computational Simulation, Morcos Hanna, Jonathan Davies, Amaryllis Fernandes, Pamela M Ketwaroo, Amy R Mehollin-Ray, Roopali Donepudi, Alice King, Joseph Hagan, Sundeep G Keswani, Sharada H Gowda, Caraciolo J Fernandes

Faculty, Staff and Students Publications

Objectives: Congenital diaphragmatic hernia (CDH) often coexists with fetal growth restriction (FGR). The observed-to-expected (O/E) total fetal lung volume (TFLV) is used to assess CDH severity, predict outcomes, and direct fetal interventions. Expected TFLV measurements traditionally rely only on gestation age (GA). This simulation assesses how incorporating weight-adjusted GA norms affects O/E TFLV calculations in patients with isolated CDH and FGR.

Methods: A simulated dataset (n=1,005) utilized published mean fetal weight and TFLV references. Computer-generated variables included observed weights (3rd-10th %ile), O/E TFLV (10-65 %), and percent liver herniation (0-42 %). GA estimates were corrected by weight and used to …

Signs, Symptoms, And Health-Related Quality Of Life In Melas: Measuring What’S Important From The Patient And Clinician Perspectives, Paolo Medrano, Benjamin Banderas, Marisa Brimmer, Lily Settel, Sari Berger, Alan Shields, Amy Goldstein, Amel Karaa, Austin Larson, Sumit Parikh, Fernando Scaglia, Karra Danyelle Harrington, Chris James Edgar, Pamela Ventola, Matthew Webster, Jennifer Chickering, Chad Gwaltney, Phebe Wilson, Chad Glasser

Faculty, Staff and Students Publications

Background and objectives: Mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS) is a rare genetic syndrome mostly associated with pathogenic variants in mitochondrial DNA. As there is limited research on the life experience of patients with MELAS, this study aimed to develop an understanding of the patient experience of MELAS through qualitative interviews to identify, describe, and substantiate important and relevant signs, symptoms, and health-related quality-of-life (HRQoL) impact (S/S/I) concepts.

Methods: Clinician and patient interviews were conducted virtually using semi-structured interview guides. During 60-minute interviews with five experts in the United States, clinicians were asked for their perspective on …

Associations Of Early-Adulthood Adiposity With Breast Parenchymal Tissue Complexity Within Premenopausal Women, Sneha Das Gupta, Kayla Getz, Juanita Hernandez Lopez, Debbie L Bennett, Adetunji T Toriola, Aimilia Gastounioti

2020-Current year OA Pubs

BACKGROUND: Early-adulthood adiposity is associated with breast cancer risk. This study aims to evaluate the associations of early-adulthood adiposity with an emerging biomarker of breast cancer risk, breast parenchymal complexity, within premenopausal women.

METHODS: We retrospectively analyzed early-adulthood adiposity data and screening digital mammograms (DMs) of 326 premenopausal women (age in years; median: 48; range: 34-58) recruited at our institution. Adiposity measures were either assessed by trained personnel or self-reported by participants. DMs were analyzed using a well-validated computational imaging pipeline consisting of automated breast segmentation and radiomic feature extraction modules. The extracted radiomic features were fused into woman-specific breast …

A Narrative Review Of Evidence, Safety, And Clinical Considerations In Taxane Chemotherapy For Pregnancy-Associated Breast Cancer, Jenny W. Zhang, Precious Ochuwa Imokhai, Danny Lee, Diana Hamdan, Trisha Mahajan, Satyam K. Singh, Amanda Brooks

Student Publications

The medical condition of pregnancy-associated breast cancer (PABC) requires oncologists to determine the best way to protect both the mother and the fetus during cancer treatment. The safety profile of taxanes, including paclitaxel and docetaxel, in the second and third trimesters of pregnancy remains unclear despite well-established anthracycline-based regimens (e.g., doxorubicin). High-risk breast cancer subtypes such as triple negative breast cancer (TNBC) and human epidermal growth factor receptor (HER2)-positive disease require taxane chemotherapy as standard treatment in nonpregnant patients. Objective: This paper aims to gather available data about the safety, timing and fetal outcomes related to taxane chemotherapy during PABC, …

Chimes: October 27, 2025, Calvin University

Chimes

Calvin's strategic planning process by Ashley Hamons

Public Health and Recreational Therapy programs phase out by Sarah Sparling

John Calvin's use of deception:A look at the French Reformation by McKenna Wilkinson

Men's soccer navigating roller coaster stretch, has eyes on MIAA tournament by Zach Kern & Hendrik Beelen

The hidden beauty of Calvin's organs by Ella Vanden Berg

Why 'religion'? A history of the department's name by Joe Toly

Resilience Factors And Physical Activity Engagement In Adolescents With Chronic Musculoskeletal Pain: A Cross-Sectional Study., William R. Black, Haley Hart, Jennifer Christofferson, Mark Connelly, Liesbet Goubert, Dustin Wallace, Laura Ellingson-Sayen, Ann M. Davis

Manuscripts, Articles, Book Chapters and Other Papers

Background/Objectives: Chronic musculoskeletal pain (CMSKP) affects up to 40% of adolescents and leads to substantial disability, reduced quality of life, and long-term health risks. Physical activity is central to treatment, but adherence to moderate-to-vigorous physical activity (MVPA) is inconsistent. We evaluated higher-resilience constructs-self-efficacy, pain acceptance, motivational stage, and affect-and hypothesized that higher resilience would be associated with greater objectively measured physical activity, better daily functioning, and higher quality of life in adolescents with CMSKP. Methods: Forty-three adolescents (13-18 years) with CMSKP completed measures of physical activity-specific self-efficacy, acceptance (AFQ-Y), motivational stage (PSOCQ-A), and affect (PANAS-C). Participants wore activPAL …

Managing Pcos In Adolescents, Michael Smith, Tania S. Burgert

Pediatrics in Practice: A CME Podcast

In this episode, Dr. Tania Burgert, a leading pediatric endocrinologist and director of the Multi-Specialty Adolescent PCOS Program at Children’s Mercy, breaks down the complexities of diagnosing and managing polycystic ovary syndrome (PCOS) in teens. She discusses the evolving diagnostic criteria, the challenges pediatricians face in early identification, and how to approach patients who may be “at risk.” Dr. Burgert also explores first-line treatment strategies, the critical role of mental health support, and how lifestyle interventions can be made sustainable for adolescents.

Click here to stream the podcast episode.

Dominant Factors Affecting Employment Opportunities In Indonesia, Muhammad Nur Afiat, Muhamad Armawaddin, Ahmad Ahmad

Jurnal Ekonomi dan Studi Pembangunan

The Classical and Keynesian debate over the equilibrium of the open economy continues today. This research uses Keynes's theory of income and Cobb-Douglas's theory of production. The purpose of this study is to examine and analyze the partial effect of consumption expenditure, government expenditure, investment, and net exports on employment opportunities in Indonesia. In particular, this study knows the dominant factors that affect employment opportunities in Indonesia. The data type uses panel data from 33 provinces and the period 2010-2022. Data analysis using panel data regression and selection variables and stepwise least square forward. The results found that the best …

Basic Dimensions And Community Welfare In The Boti Tribe In The Island Of Timora, Kamilaus Konstanse Oki

Jurnal Ekonomi dan Studi Pembangunan

The Boti tribe is the most unique indigenous traditional tribe on the island of Timor and even in the world. In the economic field, the Boti tribe fulfills economic needs independently through farming and refuses all kinds of government assistance, refuses technological production or modernization and formal education for the younger generation. However, the people of the Boti tribe feel very prosperous with their economic and socio-cultural life. The analytical tool used in this research is SmartPLS. The results show that the basic dimensions formed by the dimensions of satisfaction, meaning in life and security needs determine the very prosperous …

Indonesian Government In The Development Of The Global Electric Vehicle Industry Through Investment And Nickel Downstream, Annisa Millania Wildhani, Dyah Mutiarin

Jurnal Ekonomi dan Studi Pembangunan

This study aims to analyze the role of the Indonesian government in developing the global electric vehicle industry through the potential of nickel. This research focuses on investment and downstream case studies in Indonesia. The aim is to evaluate the strategic steps taken by the government in attracting investors and encouraging downstream activities for Indonesia's nickel potential in supporting economic growth. This research was conducted using qualitative research methods by presenting findings through online media, this research data comes from online news media. This data was obtained using the Ncapture feature on Nvivo 12 Plus. The results of the study …

Corporate Social Responsibility Optimization As Collaborative Funding Innovation To Support Sustainable Development, Lindawati Lindawati, Yudhanty Parama Sany, Sak Khie, Iwan Syahrul Anwar, Dewi Listiorini

Jurnal Ekonomi dan Studi Pembangunan

During the pandemic, development progress is hindered by budget constraints. Meanwhile, the business sector's contribution to development is minimal and charitable, with no significant impact. A program called "Kembang Jawara" has been introduced to optimize Corporate Social Responsibility (CSR) funding for development programs to address this issue. This study aimed to explore the innovation of funding called "Kembang Jawara" through a case study. The primary data was gathered through focused group discussions and interviews with the Regional Development Planning, Research and Development Agency of Subang Regency. The secondary data was sourced from proposals, work plans, reports, and policies related to …

What Drives Blue-Collar Workers Transition In The Labor Market Dynamics? Lesson Learned From Indonesia, Christiayu Natalia, Devanto Shasta Pratomo, Wildan Syafitri

Jurnal Ekonomi dan Studi Pembangunan

The recovery from the global pandemic, as well as improvements in automation technologies, have presented substantial challenges for blue-collar workers who specialized in manual work. Labor transition is considered a strategy to adapt and strengthen their resilience. This study utilizes Indonesian National Labor Force Survey / SAKERNAS data from August 2023 to examine the key factors influencing blue-collar worker transitions in Indonesia, including three primary outcomes: (1) remaining unemployed and inactive, (2) transitioning back to the blue-collar worker, and (3) transitioning to the white-collar worker. The study employs multilevel multinomial logistic regression to examine the influence of individual characteristics (e.g., …

Harnessing Collaboration For Tourism In Kuta, Bali: Dual Analysing Swot And Porters Diamond Model, I Made Chandra Mandira, I Gusti Ngurah Widya Hadi Saputra, Ni Putu Nina Eka Lestari, Anak Agung Ayu Ngurah Sri Rahayu Gorda, Anak Agung Ayu Ngurah Tini Rusmini Gorda, I Ketut Nuraga

Jurnal Ekonomi dan Studi Pembangunan

The purpose of this study is to analyse and identify the factors of utilizing collaboration and exploring the strengths, weaknesses, opportunities, and threats of tourism in Kuta Beach, Bali, using a Penta helix approach that will be concluded using Porter's Diamond Model and the identification of collaborative strategies for tourism development. The research method uses a qualitative approach with RRA (rapid rural appraisal) techniques and SWOT analysis and uses Porter's Diamond Model in concluding, assisted by the N-Vivo Plus 12 application. The informants in this study totaled 16 people, with the criteria that 10 people were traditional leaders in Kuta …

Towards Economic Resilience And Food Security: Leveraging Livelihood Capital And Technology For Farmer Adaptation In East Java, Indonesia, Bunga Hidayati, Eko Setiawan, Fitri Candra Wardana, Dini Atikawati, Maharani Pertiwi

Jurnal Ekonomi dan Studi Pembangunan

The agricultural sector's contribution in East Java Province diminished, primarily due to the prevalence of traditional farming practices, reliance on climate variability, and limited adoption of modern technology. These challenges resulted in seasonal poverty and heightened vulnerability for many farmers, impacting their economic resilience and food security. This study examined the impact of various livelihood assets on farmers' adaptive capacities in East Java, utilizing Structural Equation Modelling-Partial Least Squares (SEM-PLS) to explore both direct and indirect relationships between livelihood capital and adaptation levels. The findings revealed that livelihood capital significantly enhanced farmers' adaptive capacities directly and indirectly. Moreover, strong livelihood …

Competitiveness Of The Secondary Sector In North Kalimantan: Quantifying The Socio-Economic Impact, Djuanda Hatta, Rusdy Setiawan, Sendi Aulia Fiantika, Echa Asinah

Jurnal Ekonomi dan Studi Pembangunan

The weak support for the secondary sector in providing value-added to the primary sector can potentially become a problem in increasing GRDP in North Kalimantan. This research aimed to measure the competitiveness of the secondary sector in each region in North Kalimantan and find out how socio-economic factors influence it. Quantifying competitiveness by combining the three methods, LQ, GRM, and Shift-Share analysis, was the new method. Meanwhile, Panel data regression was carried out to determine the influence of socio-economic variables on competitiveness, which consisted of Government Expenditure, Direct Investment, and Human Development Index. Based on the results of the competitiveness …

Determinant Of Import In Indonesia, Muhamad Yunanto, Henny Medyawati

Jurnal Ekonomi dan Studi Pembangunan

Trade activities, particularly import, remain an interesting area of research. Therefore, this research aims to analyze the effect of inflation, Gross Domestic Product (GDP), Bank Indonesia interest rate (BI Rate), and exchange rates on Indonesian import. Quarterly time series data from 2010-2022 were obtained from Bank Indonesia and the Central Bureau of Statistics. Data was then analyzed using the Vector Error Correction Model (VECM) as the estimation tool. The results showed that GDP, interest rate, exchange rate, and inflation rate had a positive effect on import in the short and long term. A key contribution of this research was the …

Is Trade Openness A Supportive Instrument For Human Development: A New Look On Newly Industrialized Economies, Tufail Hussain, Teguh Yudo Wicaksono

Jurnal Ekonomi dan Studi Pembangunan

Formulating policies to enhance human well-being requires an urgent need to understand the drivers of human well-being. Therefore, the current study has proposed the socio-economic factors to investigate the main and moderate role of trade openness on Human Development for newly industrialized economies over 1990-2021. The current study shows the association between gross national income, urbanization, trade openness, labor force participation, foreign direct investment, and financial development. This study employs the fully modified and dynamic ordinary least squares for the reliable outcome. Empirical findings show that gross national income, urbanization, financial development, and labor force participation increase human development. Likewise, …