Digital Commons Network^™

Glp-1 Receptor Agonists Decrease The Colorectal Cancer Rates In Inflammatory Bowel Disease, Khaled Alsabbagh Alchirazi, Muaz Alsabbagh, Thabet Qapaja, Kinan Obeidat, Nishkarsh Kumar, Bisher Sawaf, Miguel Regueiro

Aurora GME

No abstract provided.

One-Year Risk Of Non-Variceal Gastrointestinal Bleeding Following Pci: A Real-World Comparative Analysis Of Antiplatelet Regimens Using A National Database, Khaled Alsabbagh Alchirazi, Rahul Karna, Muaz Alsabbagh, Kinan Obeidat, Fouad Jaber, Mohammad Bilal

Aurora GME

No abstract provided.

Potassium-Competitive Acid Blockers Vs Protonpump Inhibitors: A Real-World Comparative Effectiveness Study, Khaled Alsabbagh Alchirazi, Muaz Alsabbagh, Kinan Obeidat, Ahmed N. Mohamed, Michelle Baliss, Ahmad Bazarbashi

Aurora GME

No abstract provided.

Comparative Effectiveness Of Stool-Based Screening Vs Colonoscopy On Long-Term Colorectal Cancer Incidence: A Retrospective Cohort Analysis, Khaled Alsabbagh Alchirazi, Kinan Obeidat, Muaz Alsabbagh, Gregory Capelli, Zachary L. Smith, Nalini Guda

Aurora GME

No abstract provided.

Assessment Of Tumour Control Probability And Equivalent Uniform Dose In Conventional 3d-Crt Vs. Hypo-Fractionated Imrt, Jumaa D. Kisukari, Mwingereza J. Kumwenda, Khamis O. Amour, Ehab M. Attalla, Emmanuel Lugina

Tanzania Journal of Science

Hypo-fractionated (HF) radiotherapy offers a promising solution to improve access to cancer treatment in resource-limited settings, such as developing countries, by reducing the number of treatment sessions compared to conventional fractionation (CF). For effective implementation, evaluating Equivalent Uniform Dose (EUD) and Tumour Control Probability (TCP) is essential to ensure treatment efficacy across different radiotherapy techniques. This study compares treatment plans generated using Three-Dimensional Conformal Radiation Therapy with Conventional Fractionation (3D-CRT CF) and Intensity Modulated Radiation Therapy with Hypo-fractionation (IMRT HF) in patients with localized prostate cancer. A total of 50 patients were CT-simulated, and their images were imported into a …

Heavy Metal Contamination And Health Risks In Katoro's Artisanal Gold Mining Soils, Tanzania, Innocent J. Lugendo, Venance Mwesiga

Tanzania Journal of Science

This study assessed heavy metal contamination in surface soils from artisanal gold mining areas in Katoro, Tanzania, evaluating ecological and human health risks. Thirty-six soil samples were systematically collected from three mining villages (Bingwa, Isenye, and CCM) at varying distances ranging from 30 to 90 m from active mining pits alongside twelve control samples from a non-mining area for comparison purposes. Concentrations of Cr, Cu, Ni, Zn, Pb, and As in soil samples were analyzed using energy-dispersive X-ray fluorescence spectrometry (EDXRF). Results revealed severe contamination, with Cr (117–1255 mg/kg), Cu (81–104 mg/kg), and Ni (89–271 mg/kg) exceeding permissible limits. The …

Crude Extracts Of Seaweeds (Ulva Lactuca And Eucheuma Spinosum) As Biostimulants For Enhancing Sweet Pepper Production, Charles Olambo Joseph, Seif Amour M

Tanzania Journal of Science

Sweet pepper is the world’s second most important vegetable after tomato, making its production vital for economic growth and supporting livelihoods. However, growing concerns about environmental protection and sustainability make the search for eco‑friendly alternatives to synthetic fertilizers inevitable. Seaweed extracts are rich in bioactive compounds that can stimulate key plant growth and defense pathways making them effective biofertilizer. A Randomized Complete Block Design was laid out to evaluate the potential of seaweed extract (U. lactuca and E. spinosum) in promoting the growth and productivity of sweet pepper(Capsicum annuum L.). Seaweed was applied in both liquid and …

Modeling The Effects Of Screening, Vaccination, Treatment, And Non-Pharmaceutical Controls On Leptospirosis Transmission Dynamics, Janeth Michael, Herieth Rwezaura, Goodluck Mlay, Nyimvua Shaban Mbare

Tanzania Journal of Science

Leptospirosis is the world’s most common zoonotic disease and remains a significant public health challenge, particularly in regions with poor sanitation and high exposure risks. This study aims to evaluate the effectiveness of combined interventions: screening, vaccination, treatment, and non-pharmaceutical controls in reducing leptospirosis transmission in human and domestic animal populations. The study develops and analyzes a deterministic compartmental model with eleven compartments representing human, domestic animal, and bacterial populations. Stability analysis reveals that the Disease-Free Equilibrium (DEF) is globally asymptotically stable when the effective reproduction number is less than a unit ( < 1), ensuring disease eradication under these conditions, whereas the Endemic Equilibrium Point (EEP) remains stable when > 1. The study employs the normalized forward …

Mathematical Analysis Of Toxicants And Diseases Impact On A Prey-Predator System With Control Interventions, Nuru Yazidi Juma, Thadei Damas Sagamiko, James Philbert Mpele

Tanzania Journal of Science

This study developed a generic prey-predator mathematical model incorporating logistic growth for prey and a Holling Type I functional response for predator consumption. Prey-predator interactions form the foundation of ecological balance, but in recent decades these systems have been increasingly threatened by toxicants and infectious diseases. The combined effect of these challenges can lead to severe population declines, biodiversity loss, and ecosystem instability, making their study important for conservation and environmental management. The model includes the effects of diseases and toxicants on prey and toxicants only on predators, and explores optimal control strategies to mitigate these threats. Without considering time …

Rainwater Harvesting For Domestic Use In Suburb Areas Of Dar Es Salaam, Tanzania: A Case Study Of Wazo Hill, Scholastica S. Ishengoma, Mahir Mohammed Said, Neema O. Msuya

Tanzania Journal of Science

Despite the increasing reliance of rainwater harvesting in semi-urban areas, there is a lack of comprehensive localized data on the safety of harvested rainwater, particularly in areas such as Wazo Hill where communities predominantly depend on it. This study evaluates the quality of harvested rooftop rainwater intended for human consumption and assesses its compliance with the World health Organization (WHO) and Draft East Africa Standards (DEAS) for drinking water. Rainwater samples were collected from various catchment surfaces and storage systems located in Wazo Hill, Tanzania. A stratified random sampling technique was employed to select the households equipped with rainwater harvesting …

Assessment Of Bacteriological Quality And Physico-Chemical Parameters Of Domestic Water Sources In Relation To Human Health Risk In Kigamboni, Tanzania, Joseph A. Mwakosya

Tanzania Journal of Science

Data on bacteriological quality and physico-chemical parameters is crucial for protection and sustainable utilization of water resources. This study determined bacteriological quality and physico-chemical parameters of well and tap water sourcesin relation to human health risk in Kigamboni, Tanzania. Thirty water samples were collected randomly and analyzed using SPSS software. The mean values for well water samples of pH, electrical conductivity (EC), total dissolved solids (TDS), turbidity, Chloride, Sulphate, Nitrate, Phosphate, and Calcium Carbonate were 7.2, 960.27 mg/L, 528.13 mg/L, 1.52 NTU, 288.00 mg/L, 30.13 mg/L, 0.05 mg/L, 0.08 mg/L, and 160.07 mg/L, respectively. The mean values for tap water …

Morphological And Biochemical Characterization Of Endophytic Bacteria From Selected Medicinal Plants Found At The University Of Dar Es Salaam, Tanzania, Ibrahim Juma

Tanzania Journal of Science

Endophytic bacteria are capable of colonising internal tissues of medicinal plants, and producing secondary metabolites (biochemical compounds) of beneficial importance like the ones produced by their host plants. Though Tanzania harbours a wide species of medicinal plants with endophytic bacteria capable of producing such important bioactive substances, research on these bacteria remains scant, which limit their biotechnological applications. This work was undertaken to isolate and document endophytic bacteria from tropical almond, local avocado, banana and blue snake weed plants found at the University of Dar es Salaam, main campus. The study characterised the isolated endophytes based on morphological descriptors and …

A Deep Learning Approach: The Impact Of Sentiment Analysis Of Bangladeshi Workers Over The World, Md Raihanul Islam Tomal, Tanveer Kader, Kohbalan Moorthy, Mazlina Abdul Majid

Baghdad Science Journal

In today's globalized world, the pursuit of better opportunities has led to a significant increase in immigration and foreign labor. This trend is particularly evident in Bangladesh, where many workers migrate annually to destinations such as Malaysia, Qatar, Saudi Arabia, and the UAE. Understanding the sentiments and emotions of these workers is crucial to preventing crimes, suicides, political unrest, and other security issues in host countries. As maximum workers usually come from rural Bangladeshi communicate they use local dialect for conversations and very popular widely used local dialect known as Pabnaia. This study did not identify any prior research specifically …

Academic Senate - Agenda, 10/28/2025, Academic Senate

Academic Senate Agendas

No abstract provided.

Migration And U.S. Labor Market Effects Of The Mexican Drug War, Mark Borgschulte, Yuci Chen, Eduardo Medina-Cortina

Upjohn Institute Working Papers

We estimate the effect of the Mexican drug war on Mexico-to-U.S. migration and the resulting effects on population, employment, and wages in U.S. labor markets. Our empirical strategy compares U.S. counties differentially connected to Mexican municipalities through historical migration networks, using drug violence triggered by close municipal elections in 2007–2008 as a source of exogenous variation. Over the following decade, migrants fleeing the violence—the vast majority of whom are undocumented—cause native-born U.S. workers’ employment rates to increase and unemployment rates to fall, while wages do not change. Employment gains are largest for natives without a college degree. Employment effects fade …

Revisiting The 64th: Assessing And Updating A Historical Collection With New Technologies, Elizabeth H. Holt

Library Faculty Publications

Background: In November 1940, the LSU Medical Center organized the 64th US Army General Hospital to serve in the Mediterranean from 1943 to 1945. In the 1970s, members of the unit donated approximately 3000 items to a faculty member, who then donated that collection to the LSU Health Libraries; it comprises photographs, newsletters, Army reports, interviews, and correspondences. In 2011, the Libraries faculty & staff undertook digitizing and describing the collection. In 2025, given the advances made in technology since the original project, it was decided to reassess both the physical and digital versions of the collection.

Description: This presentation …

Academic Senate - Minutes, 10/28/2025, Academic Senate

Academic Senate Minutes

No abstract provided.

The George-Anne

The George-Anne

No abstract provided.

Dissecting The Intrinsic And Extrinsic Regulators Of Prostate Cancer Dormancy In The Bone Microenvironment, Mostafa M. Nasr

USF Tampa Graduate Theses and Dissertations

Metastatic disease is the primary driver of cancer-related mortality. In prostate cancer (PCa), patient survival decreases dramatically once the disease spreads to distant organs, with over 80% of metastases occurring in the bone. This dissemination is often followed by a clinically silent period of tumor dormancy that can last for years, creating a critical reservoir of cells poised for lethal relapse. A significant barrier to understanding and targeting this dormant phase has been the lack of robust experimental models. This thesis first addresses this challenge by establishing a novel stress-induced model of PCa dormancy, validated across multiple murine and human …

October 28, 2025 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

The George-Anne Inkwell Edition, Georgia Southern University

The Inkwell

No abstract provided.

Nuclear Poly(A)-Binding Protein And Nucleolin Utilize Their Rna Recognition Motifs To Read Par Chains, Leilei Shi, Morgan Dasovich, John R Horton, Hongrui Liu, Qiansheng Zhan, Swarnalatha Manickavinayaham, Collene R Jeter, Isaiah J Mixon, Nicholas M Zehrbach, Charles A Ishak, Je-Hyun Yoon, Xiaodong Cheng, Anthony K L Leung, Mark T Bedford

Faculty, Staff and Student Publications

Poly(ADP-ribosyl)ation (PARylation) is a post-translational modification mediated by ADP-ribosyltransferases, known as PARPs, which attach ADP-ribose units onto proteins, forming negatively charged multimeric chains. This modification relaxes chromatin at DNA damage sites, facilitating repair machinery access. Additionally, PAR polymers serve as docking platforms for effector proteins, termed PAR "readers", commonly involved in DNA repair. The recruitment of these proteins is mediated through conserved protein domains, including RNA recognition motifs (RRMs). Using an array of hundreds of recombinant RNA-binding domains, we systematically examined RRM interactions with PAR chains of varying lengths. Despite their chemical similarity to RNA, only a small subset of …

Epac2 Deficiency Compromises Adaptation To Dietary Acidification By Decreasing H+ Transport In The Renal Nephron, Kyrylo Pyrshev, Anna Atamanchuk, Wenli Yang, Mariya Kordysh, Fang Mei, Oleg Zaika, Xiaodong Cheng, Oleh Pochynyuk

Faculty, Staff and Student Publications

Kidneys are central in maintaining acid-base homeostasis by recovering filtered bicarbonate (HCO3-) in the proximal tubule and by secreting H+ in the collecting duct. Here, we demonstrate a critical role of the exchange protein directly activated by cAMP (Epac) signaling, and particularly the Epac2, in governing renal adaptation to dietary acid load. RNAseq analysis of the renal cortical area revealed that Epac1&2 deficiency was associated with changes in gene profile seen in acidosis. Renal expression of Epac2 but not Epac1 was enhanced by acid load. Epac2-/- mice developed a pronounced metabolic acidosis due to the inability to acidify urine in …

Long-Term Results From The Agile Study Of Azacitidine Plus Ivosidenib Vs Placebo In Newly Diagnosed Idh1-Mutated Aml, Pau Montesinos, Dylan M Marchione, Christian Recher, Michael Heuser, Susana Vives, Ewa Zarzycka, Jianxiang Wang, Marta Riva, Rodrigo T Calado, Andre C Schuh, Su-Peng Yeh, Adriana E Tron, Jianan Hui, Diego A Gianolio, Sung Choe, Prapti Patel, Stéphane De Botton, Courtney D Dinardo, Hartmut Döhner

Faculty, Staff and Student Publications

In the phase 3 AGILE study, after a 12.4-month median follow-up, ivosidenib, a mutant isocitrate dehydrogenase 1 (IDH1) inhibitor, combined with azacitidine significantly improved event-free survival, overall survival (OS), and complete remission rates compared with placebo-azacitidine in patients with newly diagnosed IDH1-mutated acute myeloid leukemia (AML), who were unfit for intensive chemotherapy. This post hoc analysis reports long-term follow-up results from AGILE after a median follow-up of 28.6 months. Overall, 148 patients were randomized to receive ivosidenib-azacitidine (n = 73) or placebo-azacitidine (n = 75). Median OS was significantly longer with ivosidenib (29.3 months; 95% confidence interval …

Comparative Analysis Of Targeted Rna-Seq And Optical Genome Mapping For Detecting Gene Rearrangements In Acute Leukemia, Chi Young Ok, Guilin Tang, Sanam Loghavi, Shimin Hu, Qing Wei, Andres E Quesada, Mark J Routbort, Rashmi Kanagal-Shamanna, C Cameron Yin, Iman Sarami, Sofia Garces, Nitin K Agarwal, Raja Luthra, Hong Fang, Fatima Zahra Jelloul, Julian Bryan, L Jeffrey Medeiros, Keyur P Patel, Gokce A Toruner

Faculty, Staff and Student Publications

Background/Objectives: Gene rearrangements involving oncogenes are major drivers in acute leukemia, influencing disease classification, prognosis, and therapeutic decision-making. Targeted RNA sequencing (RNA-Seq) panels capable of detecting intergenic and intragenic fusions across multiple genes are increasingly used in diagnostic settings. However, comparative evaluation with orthogonal technologies remains limited.

Material and Methods: We compared the performance of a 108-gene anchored multiplex PCR (AMP)-based RNA-Seq panel with that of Optical Genome Mapping (OGM) in 467 acute leukemia cases. The cohort included 360 cases of acute myeloid leukemia (AML), 89 B-lymphoblastic leukemia (B-ALL), 12 T-lymphoblastic leukemia (T-ALL), and 6 cases of mixed phenotype …

Early Intratracheal Budesonide To Reduce Bronchopulmonary Dysplasia In Extremely Preterm Infants: The Budesonide In Babies (Bib) Randomized Clinical Trial, Namasivayam Ambalavanan, Waldemar A Carlo, Kayla J Nowak, Laura Elizabeth Wiener, Shirley S Cosby, Abhay J Bhatt, Kristi L Watterberg, Brenda B Poindexter, Martin Keszler, Carl T D'Angio, Luc P Brion, Vivek Narendran, Carrie A Rau, C Michael Cotten, Matthew M Laughon, Abhik Das, Matthew A Rysavy, Anna Maria Hibbs, Janell Fuller, Karen M Puopolo, Anup Katheria, Ravi M Patel, Jennifer R Bermick, Abbot R Laptook, Irina Prelipcean, Myra H Wyckoff, Ryan Moore, Stephanie L Merhar, Robin K Ohls, Bradley A Yoder, Marta Perez, Sarvin Ghavam, Lauritz R Meyer, Valerie Y Chock, Sara B Demauro, Wesley M Jackson, Deepali Handa, Michele C Walsh

Faculty, Staff and Student Publications

Importance: Extremely preterm infants are at high risk for bronchopulmonary dysplasia (BPD) and death. Multiple small randomized clinical trials showed that a combination of budesonide with surfactant compared with surfactant alone reduced BPD or death.

Objective: To determine if early intratracheal administration of a combination of budesonide (0.25 mg/kg) mixed with surfactant, compared with surfactant alone, reduces physiologic BPD or death by 36 weeks' postmenstrual age in extremely preterm infants.

Design, setting, and participants: This double-masked randomized clinical trial was conducted from April 2021 to June 2024 in the 17 centers of the United States Neonatal Research Network. Infants 22 …

Effects Of Coffee Preparation Processes On Colloidal Particle Formation And Antioxidant Properties, Gao Guanzhen, Rao Pingfan, Xu Yao, Zhou Jianwu, Shan Yunhui

Food and Machinery

[Objective] To investigate the effects of grinding size and extraction temperature on the chemical composition, colloidal properties, and antioxidant activity of coffee colloidal particles, and to elucidate their formation and characteristics. [Methods] Coffee infusions were prepared from whole beans, medium-ground (0.9 mm), and fine-ground (0.3 mm) coffee beans using hot brewing (100 ℃, 3 min) and cold brewing (4 ℃, 24 h). The content of total solids, total sugars, proteins, total polyphenols, and lipids were determined. The colloidal properties were characterized using a nanoparticle size and zeta potential analyzer. The infusions were separated into a filtrate (true solution phase) and …

Anti-Fatigue Effects Of Euglena Extract On Mice, Zhang Jun, Xu Bin, Xi Yanli, Zheng Minghai, Han Yuxuan, Li Huimin

Food and Machinery

[Objective] To study the effects of euglena extract on the anti-fatigue and antioxidant free radical levels in mice, and to explore its specific mechanism. [Methods] A total of 40 healthy adult male Kunming mice are randomly divided into a control group (normal saline is used instead of injection to establish fatigue mice models), a low dose group (euglena extract 0.25 g/kg BW), a medium dose group (euglena extract 0.5 g/kg BW), and a high dose group (euglena extract 1.5 g/kg BW). The groups of different doses are administered by gavage. The exhaustive swimming time and fatigue rotarod test time are …

Extraction Process Optimization Of Alcohol-Soluble Proteins From Highland Barley Fermentation Spent And In Vitro Antioxidant Properties, Lyu Qian, Zhao Jie, Song Yangbo, Xu Dan, Geng Guigong, Zhang Yiquan

Food and Machinery

[Objective] To optimize the extraction process of alcohol-soluble proteins from highland barley fermentation spent, aiming to enhance the added value of byproducts from highland barley wine processing. [Methods] The alcohol-soluble proteins were extracted from highland barley fermentation spent using ultrasound-assisted ethanol extraction. The yield of alcohol-soluble proteins was used as the evaluation index to analyze the effects of four factors, i.e., solid-to-liquid ratio, ultrasound temperature, ultrasound power, and ultrasound time, on the protein yield. An orthogonal test was conducted to optimize the extraction process and determine the optimal extraction conditions. SDS-PAGE analysis was performed to examine the relative molecular mass …

Effects Of Different Drying Methods On Drying Characteristics And Quality Of Taro Strips, Li Xiaoyun, Xie Ronghua, Chen Sheng, Han Chunyang, Chen Junliang, Ren Aiqing, Duan Zhenhua

Food and Machinery

[Objective] To reduce postharvest spoilage of taro and improve the drying quality of taro strips. [Methods] Four drying methods, i.e., vacuum microwave drying (VMD), hot air drying (HAD), heat pump drying (HPD), and far-infrared radiation drying (FIRD), were used to analyze their effects on the drying characteristics, physical properties (rehydration ratio, hardness, and color difference), moisture migration and distribution, and microstructure of taro strips. [Results] In terms of drying efficiency, VMD demonstrated the shortest free water removal time, followed by HAD and HPD. For color performance, the L* value followed the order HAD >HPD >FIRD >VMD. In terms of hardness, …