Digital Commons Network^™

From Specialized To Generalized Frameworks: Broadening Machine Learning Approaches To Detect Natural Selection, Sandipan Paul Arnab

Electronic Theses and Dissertations

Natural selection leaves characteristic footprints in genomic variation, and detecting these patterns is fundamental to understanding evolutionary history and adaptation in humans. In this thesis, I present a progression of machine learning frameworks, beginning with highly specialized feature engineering and complex modeling, advancing to approaches that require minimal training, and culminating in methods that remain robust to model misspecification. First, I developed SISSSCO, a spectral feature extraction framework that applies wavelet transforms, multitaper analysis, and S-transform to genomic summary statistics, converting one-dimensional signals into two-dimensional spectral images analyzed by convolutional neural networks. SISSSCO achieved high accuracy across varied evolutionary scenarios, …

A Genealogy Of Somaesthetics: Sources And Directions, Tyler James Bonnet

Electronic Theses and Dissertations

This dissertation traces the origins of somaesthetics—an interdisciplinary field of study dedicated to the improvement and enrichment of the body’s aesthetic perception—through a genealogical method. The purpose of this method is to provide an account of the development of somaesthetics while simultaneously marshalling critical resources for its development and application. This dissertation fills a gap in somaesthetics by explicating its core philosophical commitments and its interdisciplinary composition. By means of reconstruction, the first part of this dissertation recounts the pragmatist background of somaesthetics, including fundamental commitments to experience, pluralism, and meliorism. The dissertation argues the reconstruction of pragmatism for somaesthetics …

Prospective Phase Ii Clinical Trial Of Molecular Glioblastoma (Historical Grade 2 And 3 Idh Wildtype Gliomas) Preliminary Novel Exploratory Analyses: Treatment Intensification, Margin Reduction And Epigenetic Stratified Outcomes With Radiation Therapy And Chemotherapy, Debra Nana Yeboa, Benjamin T Whitfield, Ruitao Lin, Chinenye Lynette Ejezie, Todd A Swanson, Thomas H Beckham, Chenyang Wang, Brian De, Subha Perni, Martin C Tom, Jing Li, Susan L Mcgovern, Rebecca Harrison, Nazanin K Majd, Vinay K Puduvalli, Ashley E Aaroe, Monica Loghin, Barbara J O'Brien, Anuj D Patel, Chirag B Patel, Jeffrey S Wefel, Ceylan Altintas Taslicay, Maria Gule-Monroe, Arnold C Paulino, Mary Frances Mcaleer, David R Grosshans, Amol J Ghia, Wen Jiang, Caroline Chung, Moshe Maor, Cheng-Han Yang, Maria A Gubbiotti, Carlos Kamiya-Matsuoka, Leomar Y Ballester, Shiao-Pei Weathers, Jason T Huse

Faculty, Staff and Student Publications

Purpose: Molecular glioblastoma (molGBM) is a variant lacking the full histopathological profile of glioblastoma. We report a trial aimed at addressing the optimal management of this newly recognized rarer form of glioma.

Methods: In this phase II study, molGBM patients were treated with radiation to a dose of 60Gy to the gross tumor volume (GTV) only, and a single smaller margin potentially as low as 1cm to the clinical tumor volume (CTV). As the trial is ongoing, we report on important exploratory biomarker findings correlating with median overall survival (mOS). Analysis included Kaplan-Meier and univariable/multivariable cox proportional hazard models. Available …

Cofilin Inhibition Ameliorates Piezo2 And Ampa Dysfunction In A Mouse Model Of Angelman Syndrome, Luis O Romero, Manisha Bade, Elisa Carrillo, Sonia Paz-López, Syed A M Hasan, William James Antonisamy, Vasanthi Jayaraman, Zahoor A Shah, Valeria Vásquez, Julio F Cordero-Morales

Faculty, Staff and Student Publications

Angelman syndrome (AS) is a neurogenetic disorder characterized by motor coordination and cognitive deficits. In AS, hippocampal neurons show reduced filamentous (F-)actin, a decrease we also reported in dorsal root ganglia (DRG) neurons, along with impaired mechanosensitive ion channel activity. Currently, there are no pharmacological targets to prevent the decrease of F-actin in AS. Here, we utilize a first-in-class selective cofilin inhibitor (SZ-3) to restore PIEZO2 function in DRG neurons and glutamate-evoked currents in hippocampal neurons from AS mice. Using atomic force microscopy, we demonstrate that inhibiting cofilin, an actin-severing protein, with SZ-3 increases cellular stiffness by stabilizing the actin …

Targeting Gd2 With Naxitamab Overcomes Gd3 Synthase-Driven Immune Suppression In Triple-Negative Breast Cancer, Vivek Anand, Bolutyfe Oderinde, Maryam Siddiqui, Anudishi Tyagi, Jenny Borgman, Chong Wu, Michael Andreeff, V Lokesh Battula

Faculty, Staff and Student Publications

Gangliosides are acidic glycosphingolipids involved in cell-adhesion, signal-transduction and tumor progression. GD3 synthase (GD3S/ST8SIA1), a key enzyme in ganglioside biosynthesis, is upregulated in many cancers, including GD2+ breast cancer stem-like cells (BCSCs) in triple-negative breast cancer (TNBC). Here, we demonstrated the immunomodulatory role of GD3S and identified a fully humanized anti-GD2 antibody, naxitamab, as a therapeutic tool to target GD3S/GD2+ breast tumors. GD3S expression correlates with immune-checkpoint activation and reduced immune infiltration. Ectopic overexpression of GD3S suppressed macrophage-mediated phagocytosis and NK or T cell-induced cell death in BC cells. Lipidomic analysis identified GD2 as the major effector ganglioside …

Integrating Pathogenic Variants, Polygenic Risk Score, And Family History For Prostate Cancer Risk Estimation In Men Of African Ancestry, Fei Chen, Xin Sheng, Anqi Wang, Yili Xu, Raymond Hughley, Wei Xiong, Loreall Pooler, Peggy Wan, Susan M Gundell, Godfrey Kigozi, Gertrude Nakigozi, Fred Nalugoda, Joseph Kagaayi, Grace Nalwoga Kigozi, Stephen Mugamba, Emmanuel Kyasanku, James Nkale, Vitalis Ofumbi Olwa, Alexander Lubwama, Alex Daama, Resty Nakajugo, Ben Adusei, Mohamed Jalloh, Serigne Magueye Gueye, Andrew A Adjei, James Mensah, Pedro W Fernandez, Akindele Olupelumi Adebiyi, J Olufemi Ogunbiyi, Oseremen Inokhoife Aisuodionoe-Shadrach, Lindsay Petersen, Wenlong Carl Chen, Jo Mcbride, Jeannette T Bensen, James L Mohler, Jack A Taylor, Caroline Andrews, Mbaaga Kigongo, Amanya Colline, Vicky Kiddu, Juliet Namugambe, Shallot Owamaani, Kuteesa Job, Benon Joseph Masaba, Frank Asiimwe, Proscovia Muwanga, Joy Namulondo, Florence Nagawa, Charity Kayiraba, Martin Ogwang, Ronald Okidi, David Oweka, Elio Kitara, James Obonyo, Daniel Lajul, Paul Matovu, Precious Arinda Muheki, Johnson Natumanya, Emmanuel Agaba, Emmanuel Aculokin, Amos Twongyeirwe, George Mutema, Denis Bitamazire, Eboneé N Butler, Sue Ann Ingles, Benjamin A Rybicki, Janet L Stanford, Wei Zheng, Sonja I Berndt, Stephen J Chanock, Chad D Huff, Joseph Lachance, Luc Multigner, Burcu F Darst, Timothy R Rebbeck, Laurent Brureau, Stephen Watya, David V Conti, Christopher A Haiman

Faculty, Staff and Student Publications

BACKGROUND AND OBJECTIVE: The impact of germline pathogenic variants (PVs) in cancer predisposition genes on risk of prostate cancer (PCa) remains understudied in large populations of African ancestry. This study aims to characterize the range of genetic risk of PCa and aggressive disease phenotypes in men of African ancestry.

METHODS: We analyzed 7176 PCa cases and 4873 controls from seven countries across North America and Africa to assess the association between PVs in 37 cancer predisposition genes and the risk of overall, aggressive, and metastatic PCa. Genes significantly associated with PCa risk were used to estimate lifetime absolute risk based …

The Bg News November 5, 2025, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. November 05, 2025. Volume 105-Issue 10.

Advancing Road Safety Through Data Integration, Location Accuracy, And Risk-Based Route Optimization, Lars Skaug

Electronic Theses and Dissertations

This dissertation advances transportation safety through three interconnected contributions that address fundamental challenges in crash data analysis and application. First, we present a comprehensive survey of road crash analysis methodologies, tracing the evolution from traditional statistical approaches to modern machine learning techniques while identifying critical gaps between research sophistication and practical implementation. This survey reveals that while methodological advances have been substantial, ongoing data quality issues, particularly in location accuracy and completeness, limit the effectiveness of even the most sophisticated analytical approaches.

Building on these findings, we develop a novel system to validate and correct crash location data using multi-modal …

Mutant P53 Variants Differentially Impact Replication Initiation And Activate Cgas-Sting To Affect Immune Checkpoint Inhibition, Kang Liu, Lidija A Wilhelms Garan, Fang-Tsyr Lin, Weei-Chin Lin

Faculty, Staff and Students Publications

Prior research shows that Akt-dependent phosphorylation of TopBP1 in S phase results in the switch of TopBP1/Treslin binding to TopBP1/E2F1 binding, which is important to prevent replication re-initiation in late S and G2 phases. Here, we demonstrate that contact, but not conformational, mutant p53 can override this switch by binding to both TopBP1 and Treslin, thereby facilitating persistent TopBP1/Treslin interaction in late S and G2 phases, which ultimately leads to over-firing of replication initiation. This increases micronuclei formation, which is further enhanced by genotoxic stressors such as doxorubicin, PARP inhibitors, or ATR inhibitors. Consequently, contact mutant p53 increases the sensitivity …

Prolonged Dysregulation Of Gene Expression And Biomarkers Of Coagulation, Fibrinolysis, And Endothelium In Pediatric Central Nervous System Malaria, Arlene E Dent, Bruce A Rosa, Katherine R Dobbs, Sidney Ogolla, David Midem, Paula Embury, Yelenna Skomorovska-Prokvolit, Emily R Hannon, Emmily Koech, Alvin H Schmaier, Walter Otieno, Makedonka Mitreva, James W Kazura

2020-Current year OA Pubs

BACKGROUND: Children with central nervous system malaria (CNS-M) have gene expression profiles and plasma biomarkers of malaria pathogenesis that differ from children with uncomplicated malaria (UM, malaria infection with fever and no systemic organ dysfunction) or acute febrile non-malaria illness (AFN). However, there is scant knowledge of the temporal dynamics of gene expression and plasma biomarkers during recovery from CNS-M.

METHODS: We compared serial changes of peripheral blood mononuclear cell transcriptomes at 6 weeks after recovery and plasma biomarkers of malaria pathogenesis at 6 weeks and 6 months after recovery in cohorts of Kenyan children who presented with CNS-M ( …

Outcomes Of Relapse After Teclistamab Therapy In Multiple Myeloma, Kyle L. Yu, Matthew Ho, Luca Paruzzo, Federico Stella, Heta Patel, Zainul S Hasanali, Shivani Kapur, Adam J. Waxman, Dan T. Vogl, Edward A. Stadtmauer, Joseph A. Fraietta, Marco Ruella, Adam D. Cohen, Alfred L. Garfall, Sandra Susanibar-Adaniya

Student Papers, Posters & Projects

No abstract provided.

New Appointments

Journal of East Asian Libraries

No abstract provided.

The Historical Shift On Depression: Psychoanalysis To Neuroscience, Melina Kehtar-Navaz

The Bear Counseling Collective

Depression, a condition that affects millions of people worldwide, has been an important subject for the collaboration between psychologists, medical doctors, and beyond. Over the past century, our understanding of depression has undergone a transformation from theory-driven insights of psychoanalysis to the biological and brain-based medical and cognitive models that currently dominate research in the field. In the early 20th century, psychoanalysts like Sigmund Freud proposed an original definition and cause for depression, including components of unconscious conflicts. Today, with advancements in neuroscience and biological psychiatry, depression is a disorder of the brain that is affected by multiple components of …

Theoretical Exploration: Feederism And Precarious Manhood, Schneebeck

The Bear Counseling Collective

The internet provides a peek into the lives of niche communities that one might not otherwise encounter in daily life. Stumbling into a unique subculture can intrigue, befuddle, or even disturb the outside viewer. The traditional physical barriers between sexual fetishes and the outside world are diminished with a few clicks of the keyboard. One sexual fetish gaining internet traction, even outside of the explicitly adult online spaces, is that of feederism. Feederism’s growing infamy comes from its odd and extreme departure from what is considered “normal” – an overt sexualization of force feeding a partner with intent of weight …

Breaking The Cycle: Addressing The Stigma Of Non-Offending Individuals To Reduce The Risk Of Child Sexual Abuse, Olinda Moro López

The Bear Counseling Collective

Child Sexual Abuse (CSA) is a significant public health issue worldwide. Estimates from the U.S. Centers for Disease Control and Prevention (CDC) indicate that 25% of girls and 5% of boys have experienced sexual abuse (Centers for Disease Control and Prevention, 2024). However, the CDC’s statistics only reflect criminal convictions of CSA cases. Notably, a 2011 meta-analysis comparing official CSA data from 217 studies with approximately 10 million self-reported samples revealed that prevalence rates could be as much as 30 times higher than official statistics suggest (Beier et al., 2024; Stoltenborgh et al., 2011). This discrepancy highlights significant under-detection and …

Theoretical Review: Finding The Light In Logotherapy, Lexi Lucas Moore

The Bear Counseling Collective

As humans, we face many forms of fire: the singe of a broken relationship, the smolder of death, and even the blaze of abuse. However, we endure the burn, and eventually, our resilience illuminates into hope. Viktor E. Frankl (1946) once said, “What is to give light must endure burning.” This tumultuous journey of rising from the ashes was familiar to Viktor, as it was a matter of his survival during his experience of the Holocaust. While imprisoned in concentration camps, Viktor developed logotherapy as a theoretical lens to promote freedom. With four universal tenants, the theory is an act …

Psychological Service Clinic: An Interview With Dr. Johnson, Leah K. Skelton

The Bear Counseling Collective

With the long wait list and high demand for mental health services, many people may have trouble finding affordable mental health services in the northern Colorado area. As director of the psychological services clinic, Dr. Johnson helped shed light on a service available in the Greeley community that many may not be aware of through the University of Northern Colorado’s Psychological Services Clinic (PSC). In an effort to help highlight this service, I sat down with Dr. Johnson to talk with him about what the PSC has to offer people in the community and the process of obtaining services.

Loneliness And The Experience Of Addiction And Recovery In Older Adults, Chalan Carpenter

The Bear Counseling Collective

Physical, emotional, and cognitive age-related changes are challenging processes for an individual to manage as they age. The aging population has higher rates of social isolation and feelings of loneliness (Haroutunian, 2016). While loneliness can be seen as an emotional experience, it also can be viewed as an age-related change. As individuals age, they will typically experience a decrease in relationships and social interaction. The experience of loneliness or isolation is a negative emotional experience which can affect a person’s ability to cope with stress and age-related changes, and to achieve developmental milestones. Through interviews with participants recovering from alcohol …

Comparing Characteristics Of Southern Illinois And Western Kentucky Soils, Jenna Grab, Jodi Terhorst, Madelyn G. Hughes, Kaitlynn R. Burrus

Scholars Week

Comparing Characteristics

of Southern Illinois and Western Kentucky Soils

Jenna Grab, Kaitlynn Burrus, Madelyn Hughes & Jodi Terhorst

Mentor: Dr. Iin Handayani, Ph.D.

Hutson School of Agriculture, Murray State University, Kentucky, USA

ABSTRACT

Assessing soil quality indicators is essential to determining soil health for plant growth. The objective of this study was to determine and compare various physical and chemical characteristics of soils in Western Kentucky (KY) and Southern Illinois (IL). Twenty-seven undisturbed and twenty-seven disturbed soil samples were collected from September 5th-27th from fields in Mascoutah and Metropolis, Illinois, along with fields in Schochoh and Benton, Kentucky. All soil …

Evaluating Soil Responses To Three Different Tillage Practices, Robert L. Burchett, Cordale L. Straub Senior, Logan D. Renfrow Sophomore

Scholars Week

Evaluating Soil Responses to Three Different Tillage Practices

Luke Burchett, Logan Renfrow, and Cordale Straub

Mentor: Dr. Iin Handayani Ph.D

Hutson School of Agriculture, Murray State University, Kentucky, USA

ABSTRACT

Tillage systems can greatly affect soil health by changing its structure, chemistry, and biological activity. This study examined how soil organic carbon (SOC), soil pH, soil moisture, soil organic matter (SOM) responds under three tillage systems: no-till, biannual tillage, and conventional tillage. Soil samples were taken from a 1–7.6 cm depth during September 2025 across three locations. The no-till site was located in Caldwell County, Kentucky, on an irrigated double-crop …

Impact Of Crop Rotation And Species Variation On Soil Quality Indicators, Somasekhar Auduti, Uday Kiran Pittala, Pratibha Adhikari

Scholars Week

Impact of Crop Rotation and Species Variation on Soil Quality Indicators

Pratibha Adhikari, Somasekhar Auduti, Uday Kiran Pittala

Mentor: Dr. Iin P. Handayani, Ph.D.

Hutson School of Agriculture, Murray State University, Murray, KY, USA

Designing crop rotations that counter the negative effects of monocropping requires crop choices that build carbon and create stable pore structure. The objective of this research was to evaluate the effects of crop rotation on selected soil health indicators and to interpret soil health conditions across agricultural fields. Soil samples were collected from West Farm, Murray, KY, from six crop fields—corn, soybean, tobacco, millet, cotton, and …

Assessing Soil Properties Under Pastures Managed For Different Livestock Systems In Western Kentucky, Chandralekha Joga Miss

Scholars Week

Soil health plays a vital role in sustainable agriculture, particularly in pasture-based livestock systems that influence physical and chemical soil properties. This study evaluated the effects of different livestock systems on surface soil characteristics in western Kentucky. Soil samples were collected from September 16 to September 22, 2025. Six fields were selected, representing beef, equine, swine, sheep/goat, poultry, and control (no livestock) systems. Both disturbed and undisturbed samples were collected from one soil depth (0–7.5 cm) to assess physical and chemical properties including bulk density (BD), total porosity, macroporosity, soil water holding capacity (SWHC), soil water at field capacity (SWFC), …

Shaping The Soil: A Comparison Of Equine, Bovine, And Ungrazed Hay Fields, Brody Ellis Higgs, Taylor Madison Wynn, Scottie Craig Berry

Scholars Week

Shaping the Soil: A Comparison of Equine, Bovine, and Ungrazed Hay Fields

Brody Higgs, Taylor Wynn, and Scottie Berry

Mentor: Dr. Iin. P. Handayani, PhD.

Hutson School of Agriculture, Murray State University, Murray, Kentucky, USA

ABSTRACT

Kentucky raises grazing species for multiple reasons, including food, recreation, and show. The most common of them are equine and bovine. These animals graze many acres across the state of Kentucky and impact soil properties in their pastures. This study was conducted on three pasturelands across Caldwell and Calloway counties in Kentucky. The pastures consisted of a cow pasture, a horse pasture, and a …

Assessing Soil Quality Indicators In Leguminous And Non-Leguminous Cropping Systems, Kabita Budthapa, Kranthi Vinukonda, Ramya Sree Teeguri

Scholars Week

It is crucial to understand how different cropping systems influence soil health to boost the efficiency of resources and sustainable agricultural outputs. This study examined the effects of leguminous (soybean and pea) and non-leguminous (sunflower and maize) cropping systems on selected soil characteristics. On September 16th, 2025, soil samples (24 disturbed and 24 undisturbed) were collected from the 0-7.5 cm depth of West Farm, Murray, Kentucky. Disturbed samples were analyzed for pH, soil organic matter (SOM), and soil organic carbon (SOC), while undisturbed samples were used to determine bulk density, porosity, soil water holding capacity (SWHC), and soil water field …

Comparative Assessment Of Soil Properties In Cropland And Forested Areas In Western Kentucky, Shiba Hari Dhakal, Abinash Dhungana, Ramson K C

Scholars Week

Soil health is profoundly influenced by its physical and chemical properties. These properties rely on land use systems; consequently, impact on soil functions and agricultural sustainability. The objective of this study was to determine selected physical and chemical properties affected by crop and forest management in Western Kentucky. Two crop and two forested areas with six replications each were selected for this study in September 2025 in Calloway County, Kentucky. A total of 24 disturbed and 24 undisturbed soil samples were collected at 0-7 cm depth. Disturbed samples were analyzed for soil pH, soil organic matter (SOM), and soil organic …

Evaluating Fungicide Efficacy In One And Two-Pass Fungicide Programs, Carson Buchanan

Scholars Week

Evaluating Fungicide Efficacy in One and Two-Pass Fungicide Programs

Carson Buchanan

Mentors: Dr. Megan Taylor, Dr. Iin Handayani

Murray State University, Murray, Kentucky, USA Abstract

Plant diseases continually threaten corn yields year after year. This study compared regionally important corn hybrids in a one-pass and two-pass application system. Eight rows of sixteen hybrids were planted in a field in Bargersville, Indiana. These hybrids consisted mostly of regionally important Dekalb hybrids, along with some competitive Pioneer hybrids. The entire field then got a V8 application of Stratego YLD. The field was then split in half and one half of the field …

Learning And Satisfaction, Ainsley Smith

Scholars Week

Learning and Satisfaction

Motivation, especially in the world of psychology, is quite the broad and overarching term that relates to various aspects of life. Whether it be motivation in the workplace, classroom, sports, or relationships, our intrinsic and extrinsic motivations drive us to do our best on what we set forth to accomplish. Although there is extensive research on methods of learning in correlation to motivation as well as levels of satisfaction impacting these levels, there has yet to be much exploration into the impact an emotional component or personal connection may have on these factors. The purpose of this …

Planning For Prevention: Implementing Pressure Injury Bundles In Hospice Settings, Ellie M. Martin, Mckenzie Pool

Scholars Week

There is an increased prevalence of pressure-related injuries in the hospice setting. This can be due to age, diagnosis, comorbidities, inadequate nutrition or hydration, lack of mobility, or inadequate care due to lack of education. Prevention bundles and policies are at every facility, but are not as effective as needed. This looks at the theoretical framework and ways to prevent pressure injuries as effectively as possible. Pulling information from multiple other research studies to put the best care bundle together to decrease the amount of pressure injuries.

Improved Patient Outcomes With Continuous Video Monitoring, Ethan Morrison, Drake May, Jack L. Rideout

Scholars Week

Improved Patient Outcomes with Continuous Video Monitoring

Objective

The use of human sitters has been the normal policy in hospitals across the United States for years. Recently, there has been an introduction to remote video monitoring systems that are aimed at replacing the need for human sitters. Our goal is to change the policy of a local hospital in our area to adjust their stance on human sitters and implement remote video monitoring.

Methods/Results

Our method of accomplishing this involved a PowerPoint presentation and an evidence-based practice paper with three different scholarly research articles that have been peer-reviewed. We presented …

Antibiotic Stewardship And The Prevention Of Healthcare-Associated C.Diff, Nevaeh Tyson, Angel Pearson

Scholars Week

Healthcare-associated Clostridium difficile (C.difficile) infections remain a significant burden to many healthcare facilities across North America. This infection is often linked to long-term antibiotic use and ineffective infection control methods. This presentation addresses current evidence-based practice protocols on the prevention of C.difficile, emphasizing the need for increased monitoring of antibiotic therapy and improved infection control strategies.