Digital Commons Network^™

Neutrosophic Topological Spaces For Spatially-Aware Uncertainty Modeling In Lung Cancer Diagnosis, S. A. Alblowi, A.A. Salama, Huda E. Khalid, Ahmed Essa, Arafa A.Nasef

Neutrosophic Sets and Systems

No abstract provided.

A Neutrosophic Extension Of The Inverse Gamma Distribution: Properties And Applications, Fuad S. Alduais

Neutrosophic Sets and Systems

No abstract provided.

Early Detection Of Epidemics Using Generalized Additive Models And Hidden Markov Models: A Neutrosophic Statistical Approach With Real-Time Health Data, Ammar Kuti Nasser

Neutrosophic Sets and Systems

No abstract provided.

Neutrosophic Modeling And Redesign Effects Analysis Of Abandoned Buildings In The Context Of Urban Renewal: A Spatial Probabilistic Framework For Urban Hazard Risk, Zhiyong Tian

Neutrosophic Sets and Systems

No abstract provided.

Q-Neutrosophic Soft Relation For Training Effects Of Rock Climbing: A Pathway To Physical Fitness And Psychological Growth In Adolescents, Yuzhen Zhan

Neutrosophic Sets and Systems

No abstract provided.

Correlation Coefficient Under Rough Neutrosophic Set For Effectiveness Assessment Of Students' Mental Health Education In Higher Education Institutions, Shuang Cui

Neutrosophic Sets and Systems

No abstract provided.

Big Data Informatization Empowers Integrity Building In University Sports Under Type-2 Neutrosophic Fuzzy Sets: Theoretical Framework, Practical Dilemmas And Institutional Innovation Evaluation, Jie Zhou

Neutrosophic Sets and Systems

No abstract provided.

Evaluation Of Heterotopic Ossification Following Two-Level Cervical Disc Arthroplasty With A Peek-On-Ceramic Artificial Disc, Jad Khalil, Hyan Bae, Pierce Nunley, K Brandon Strenge, Ashvin Patel, Armen Khachatryan, Rick Sasso, Andrew Park, Christopher Good, James Yue, Paul Kim, Richard Guyer

Conference Presentation Abstracts

Introduction: While favorable outcomes have consistently been reported following treatment of disc degeneration with cervical total disc replacement (cTDR), the development of heterotopic ossification (HO) at the index level has been reported. This study evaluated baseline characteristics potentially associated with the development of HO, as well as the impact of HO on 5-year clinical outcomes Materials and Methods: Baseline characteristics and 5-year outcomes of two-level polyetheretherketone (PEEK)-on-ceramic cTDR patients were stratified by worst HO grade at either index level through 5 years (defined as grade 1, 2, 3 or 4 on the McAfee/Mehren scale). Baseline index-level radiographic variables were stratified …

Rapid Evidence Review: Terror Incidents And Perceived Terrorism Risks At Events, Tin L. Nguyen, Callie Vitro, Sarah Schappert, Allison E. Munderloh, Erin M. Kearns

Reports, Projects, and Research

Since the 1972 Munich Olympics, mass gatherings for sport, music, and other entertainment have been viewed as highly vulnerable, culturally significant targets for terrorist attacks. Although research on the enactment and implications of terrorism have become more commonplace, comparatively little research has examined terrorism in the context of organized gatherings and the event venues which host them. Through a rapid evidence review, we summarize empirical research on (a) international incidents of terrorism and (b) perceived terrorism risks at large-scale public events and event venues, as well as (c) their psychological, behavioral, and social/news media effects. This research brief is intended …

Acculturation, Values, And Acculturative Stress For Autistic Latino Emerging Adults And Spanish-Speaking Parents Participating In The ¡Iniciando! La Adultez Program, Antonio F. Pagán, Miriam Ortiz, Erin Bernal, Katherine A. Loveland, Ana Esparza, Cecilia Montiel-Nava, Ron Acierno

Psychological Science Faculty Publications

Latino families with emerging adults diagnosed with Autism Spectrum Disorder (ASD) face unique challenges during the transition to adulthood, influenced by cultural values, acculturation, and systemic barriers. Acculturation and acculturative stress are particularly relevant in this population, as they navigate cultural adaptation while maintaining traditional values like familismo (family) and respeto (respect). These dynamics are further complicated by disparities in access to resources and culturally responsive interventions. This study explores the interplay of cultural values, acculturation, and acculturative stress among Latino emerging adults with ASD and their Spanish-speaking parents participating in a culturally adapted and translated intervention. Using a cross-sectional …

Interpersonal Communication: A Mindful Approach To Relationships 2nd Edition, Jason S. Wrench, Narissra M. Punyanunt-Carter, Katherine S, Thweatt

Milne Open Textbooks

Interpersonal communication is the way we connect with others. Whether engaging with a spouse, a coworker, a close friend, or a stranger, our daily lives are defined by the messages we send and receive. Interpersonal Communication guides students through the complex landscape of human interaction, helping them navigate relationships in the twenty-first century.

A Mindful Perspective

What distinguishes this textbook is its integration of mindfulness into the study of communication. Moving beyond simple skills training, the text encourages students to engage in mindful awareness and mindful practice. By learning to be fully present, open, and non-judgmental, students develop the …

The Future Is Now: Empowering Society Through Ai Literacy, Jason S. Wrench, Sanae Elmoudden

Milne Open Textbooks

Artificial Intelligence (AI) is no longer a futuristic concept—it is the reality of the present. From the algorithms shaping our social media feeds to the generative tools transforming our workplaces, AI has permeated every aspect of modern life. The Future is Now moves beyond the hype to provide a comprehensive roadmap for understanding, navigating, and shaping this technological revolution.

Demystifying the Machine

This textbook serves as a user-friendly guide to the “black box” of AI. It breaks down complex technical concepts—from machine learning and neural networks to large language models—making them accessible to students across all disciplines. By establishing a …

Overcoming Title 42 And The 2022-3 Venezuelan Migrant Expulsion Spectacle: A Border Securocracy Case Study, Terence M. Garrett, Arthur Sementelli

School of Political Science, Public Affairs, Legal and Security Studies Faculty Publications

On October 12, 2022, the Biden administration abruptly changed course and announced that Venezuelan refugees would be immediately subject to Title 42—the policy that effectively means that those migrants would be summarily forced to return, or expelled, to Mexico. For FY 2022, Customs and Border Protection apprehended and/or expelled a total of 2,766,582 enforcement actions (CBP FY 2022). The resulting media spectacle illustrates another example of border securocracy—defined as the globalized border industrial apparatus oppressing the masses from the global south. We construct a case study based on Boje's narrative approach to illustrate how guided discussions of Title 42 …

Predicting Five-Year Comorbid Bipolar Disorder After Attention-Deficit/Hyperactivity Disorder Diagnosis: A Population-Based Machine Learning Approach, Yen-Shan Yang, Chih-Wei Hsu, Liang-Jen Wang, Kuo-Chuan Hung, Yang-Chieh Brian Chen, Chih-Sung Liang, Mu-Hong Chen

Children’s Nutrition Research Center Staff Publications

Background

Early detection and accurate prediction of bipolar disorders (BDs) comorbidity in individuals with attention-deficit/hyperactivity disorder (ADHD) are clinically critical. This study used machine-learning methods to identify features predictive of subsequent BD among patients initially diagnosed with ADHD.

Methods

We analyzed claims from the Taiwan National Health Insurance Research Database (2000–2013) and included patients aged ≥ 12 years with at least two diagnoses of ADHD. Predictor features included demographics (sex, age at ADHD onset), healthcare utilization (psychiatric outpatient visit counts), comorbidities (International Classification of Diseases–coded diagnoses), psychiatric medications (Anatomical Therapeutic Chemical–coded prescriptions), and family psychiatric history. All features were extracted …

A Class Of Benzofuranoindoline-Bearing Heptacyclic Fungal Ripps With Anticancer Activities, Qiuyue Nie, Fanglong Zhao, Xuerong Yu, Mithun C Madhusudhanan, Caleb Chang, Siting Li, Sandipan Roy Chowdhury, Bryce Kille, Andy Xu, Rory Sharkey, Chunxiao Sun, Hongzhi Zeng, Shuai Liu, Dishu Zhou, Xin Yu, Kevin Yang, Sandra A C Figueiredo, Maria Zotova, Zichen Hu, Alan Y Du, Dongyin Guan, Rui Tang, Todd Treangen, Jin Wang, Pedro N Leão, Yang Gao, Junjie Chen, Peng Liu, Hans Renata, Xue Gao

Children’s Nutrition Research Center Staff Publications

Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a promising source of new pharmaceuticals, yet the therapeutic potential of fungal RiPPs remains largely underexplored. Here, we report asperigimycins as a distinct class of fungal RiPPs, featuring a unique heptacyclic scaffold consisting of a benzofuranoindoline core and three additional macrocycles, primarily assembled by six distinct fungi-specific DUF3328 oxidases. Inspired by the enhancement of anticancer activity through the N-terminal pyroglutamate in naturally occurring asperigimycins C and D, we chemically modify the inactive asperigimycin B with a series of lipid substitutions at its N-terminus. A derivative with a C-11 linear fatty …

Intentional Ai: Preserving Skills, Judgment And Humanity

Metro Denver Dental Society Articulator Magazine

Dr. Amisha Singh explores the rapid rise of AI across dentistry, highlighting both its transformative potential and the ethical, cognitive and professional risks that come with overreliance. She emphasizes the need for intentional use, critical thinking and boundaries that preserve core clinical and human skills. Her reflection offers a roadmap for using AI as an amplifier of expertise rather than a replacement for it.

State Of Omics-Based Microbial Diagnostics Of Crc, Jerome Prusa, Mark G Gorelik, Kevin S Blake, Gautam Dantas

2020-Current year OA Pubs

Colorectal cancer (CRC) remains a major burden of cancer-related morbidity and mortality globally, especially when detected at later stages. Early detection through improved and more accessible diagnostics is critical for reducing the severity of CRC. As our understanding of CRC and the microbial inhabitants of the gastrointestinal tract continues to improve, it has become increasingly recognized that the bacterial component of the gut microbiome may provide diagnostic utility for detecting CRC. This is because CRC is often accompanied by shifts in bacterial taxa, and the metabolites produced or utilized by the CRC-associated gut bacterial community. Advances in sequencing and metabolite …

A Novel Lncrna Fam151b-Dt Regulates Degradation Of Aggregation Prone Proteins, Arun Renganathan, Miguel A Minaya, Matthew Broder, Isabel Alfradique-Dunham, Rebecca L Miller, Dhruva D Dhavale, Reshma Bhagat, Jacob Marsh, Anthony Verbeck, Grant Galasso, Emma Starr, Paul T Kotzbauer, Carlos Cruchaga, Celeste M Karch, Et Al.

2020-Current year OA Pubs

Neurodegenerative diseases share common features of protein aggregation along with other pleiotropic traits, including shifts in transcriptional patterns, neuroinflammation, disruption in synaptic signaling, mitochondrial dysfunction, oxidative stress, and impaired clearance mechanisms like autophagy. However, key regulators of these pleiotropic traits have yet to be identified. Here, we used transcriptomics, mass spectrometry, and biochemical assays to define the role of a novel lncRNA on tau pathophysiology. We discovered a long non-coding RNA (lncRNA), FAM151B-DT, that is reduced in a stem cell model of frontotemporal lobar dementia with tau inclusions (FTLD-tau) and in brains from FTLD-tau, progressive supranuclear palsy, Alzheimer's disease, and …

Pan-Cancer Single Cell Transcriptomic Clustering Reveals Heterogeneous Cd8+ Exhausted T Cell Populations With Different Immune Checkpoint Inhibitor Responses, Rui Mu, Rasha Barakat, David H Gutmann

2020-Current year OA Pubs

In most cancers, T lymphocytes comprise an essential cellular component of the non-neoplastic microenvironment, where they have the capacity to both suppress and support tumor growth. One specialized T lymphocyte population is the CD8

Lymphoid Gene Expression Supports Neuroprotective Microglia Function, Pinar Ayata, Maud Gratuze, Jason D Ulrich, David M Holtzman, Et Al.

2020-Current year OA Pubs

Microglia, the innate immune cells of the brain, play a defining role in the progression of Alzheimer's disease (AD)

Age-Dependent Zap70 Expression In Thymocytes Regulates Selection Of The Neonatal Regulatory T Cell Repertoire, Brian D Stadinski, Robert A Campbell, Et Al.

2020-Current year OA Pubs

The Foxp3⁺ regulatory T (T

Streptavidin-Drug Conjugates Streamline Optimization Of Antibody-Based Hematopoietic Stem Cell Transplant Conditioning, Aditya R Yelamali, Ezhilarasi Chendamarai, Julie K Ritchey, Michael P Rettig, John F Dipersio, Stephen P Persaud

2020-Current year OA Pubs

Hematopoietic stem cell transplantation (HSCT) conditioning using antibody-drug conjugates (ADC) is a promising approach to preparing patients for transplant, potentially avoiding the severe toxicities of conventional chemotherapy- and irradiation-based conditioning regimens. The toxic payload determines the efficacy and potential toxicities of an ADC, but comparison of different payloads in conjugates designed for HSCT conditioning has not been reported. Such comparisons would be greatly facilitated by methods enabling efficient screening of many combinations of antibody and payload. Herein, we used Click chemistry to conjugate four different small molecule payloads to a streptavidin backbone, yielding streptavidin-drug conjugates that can be combined with …

Proteogenomics In Cerebrospinal Fluid And Plasma Reveals New Biological Fingerprint Of Cerebral Small Vessel Disease, Ilana Caro, Daniel Western, Chengran Yang, Jigyasha Timsina, Laura Ibanez, Carlos Cruchaga, Et Al.

2020-Current year OA Pubs

Cerebral small vessel disease (cSVD) is a leading cause of stroke and dementia with no specific treatment, of which molecular mechanisms remain poorly understood. To identify potential biomarkers and therapeutic targets, we applied Mendelian randomization to examine over 2,500 proteins measured in plasma and, uniquely, cerebrospinal fluid, in relation to magnetic resonance imaging (MRI) markers of cSVD in more than 40,000 individuals. Here we show that 49 proteins are associated with MRI markers of cSVD, most prominently in cerebrospinal fluid. We highlight associations that are consistent across platforms and ancestries, and supported by complementary observational analyses, and we explore differences …

From Sex Differences To Sex Inequalities In Life Expectancy: A Cross-Country Observational Benchmarking Analysis, Angela Y. Chang, Emily K. Johnson, Sarah Bolongaita, Kent Buse, Sarah J. Hawkes, Omar Karlsson, Felicia M. Knaul, Margaret E. Kruk, Ole F. Norheim, Osondu Ogbuoji, David Watkins, Dean T. Jamison

2020-Current year OA Pubs

BACKGROUND: The answer to whether females or males have better health, and which sex is the more disadvantaged, has depended in part on the metric and how the inequality is measured. This study introduces a new method for analyzing and interpreting sex inequalities in health outcomes-defined as the avoidable sex differences in health outcomes-that is systematic and potentially more objective. For this paper, we focus on life expectancy at different ages.

METHODS AND FINDINGS: We introduce the adjusted sex ratio as a measure of sex inequalities and determining sex disadvantage. First, we calculated the sex ratio of life expectancy at …

Parental Influence On Youth Cannabis Use: The Interplay Between Disapproval And Warmth, Brian Young, Lorey Wheeler, Hongying Daisy Dai

Student Publications

Purpose: Family environment plays an essential role in youth development. This study sought to examine the intersection effects of parental disapproval and parent–child warm relationships on youth cannabis use behaviors.

Methods: Data were drawn from the youth sample of the 2022 National Survey on Drug Use and Health (NSDUH) study. Multivariable hierarchical models were performed to examine the associations of parental disapproval of offspring’s cannabis use and youth current (past 30-day) cannabis use and past-year DSM-5 cannabis use disorder (CUD), incrementally adjusting for sociodemographic factors, youth substance use behaviors, and family/environment influences.

Results: Among a nationally representative …

Semi-Annual And Annual Mass Drug Administration Of Diethylcarbamazine And Albendazole Are Equally Effective Regimens For Eliminating Lymphatic Filariasis In Papua New Guinea, Michael C. Payne, Nelly Sanuku, Brooke E. Mancuso, Yao-Chieh Cheng, Gary J. Weil, Peter U. Fischer, Moses Laman, Leanne J. Robinson, Daniel J. Tisch, Christopher L King

2020-Current year OA Pubs

Annual mass drug administration (MDA) is currently recommended for the local elimination of lymphatic filariasis (LF). Modeling studies of LF transmission suggest that conducting MDA twice a year could accelerate LF elimination. To test this idea, we compared the effects of 3 rounds of yearly MDA and 5 rounds of semiannual MDA using diethylcarbamazine with albendazole on LF infection measures in Papua New Guinea (PNG) across 2 treatment areas with high LF prevalence. From 2013 to 2018, we conducted 4 annual community surveys at 4 sentinel sites in each treatment area. We sampled 2,854 people at the start and 2,746, …

The Impact Of Sleep In High-Risk Infants, Ann-Cathrine Neukamm, Mirja Quante, Christian F Poets, Renée A Shellhaas, “Neonatal Sleep Talks (Nest)” Group

2020-Current year OA Pubs

Most of an infant's day is devoted to sleep - and normal sleep is vital to normal brain development. Sleep disruptions may impair overall health, well-being, and neurodevelopment. Disruptors of sleep and circadian health, such as noise, light, respiratory support, and clinical interventions, are highly prevalent in hospital and nursing care facilities. These factors particularly affect infants who already have an increased risk of sleep disorders and their consequences due to an underlying disease. Preterm infants and infants with disorders such as neonatal abstinence syndrome, craniofacial malformations, congenital heart disease, hypoxic-ischemic encephalopathy, Chiari-malformation/myelomeningocele, congenital musculoskeletal disease, and Down syndrome are …

Bilateral Breast Treatment In A Single Arc Using Rapidarc Dynamic: A Planning Comparison With Conventional Volumetric Modulated Arc Therapy, Taoran Li, Luca Cozzi, Lesley Rosa, Ryan Clark, Priyanka Agarwal, Yin Gao, Yun Yang, Boon-Keng Kevin Teo, Anthony Magliari, Himank Kalra, Francisco Reynoso, Patrick Kupelian, Sushil Beriwal

2020-Current year OA Pubs

PURPOSE: Synchronous bilateral breast cancer (SBBC) presents significant radiotherapy planning challenges due to complex target volumes near critical organs. This study evaluated RapidArc Dynamic (RAD), a novel technique integrating dynamic arcs with static angle modulated ports (STAMPs) via simultaneous GPU-accelerated optimization, against conventional volumetric modulated arc therapy (VMAT) for SBBC treatment planning and delivery efficiency.

METHODS: Ten retrospective SBBC cases involving comprehensive nodal irradiation were planned using both multi-arc VMAT (six arcs) and RAD (one arc plus six STAMPs) in Eclipse (v18.1) with AcurosXB. A prescription dose of 40.05 Gy in 15 fractions was normalized to PTV D95% = 95%. …

Brain Functional Connectivity, But Not Neuroanatomy, Captures The Interrelationship Between Sex And Gender In Preadolescents, Athanasia Metoki, Roselyne J Chauvin, Evan M Gordon, Timothy O Laumann, Benjamin P Kay, Babatunde Adeyemo, Samuel R Krimmel, Scott Marek, Anxu Wang, Andrew N Van, Noah J Baden, Vahdeta Suljic, Kristen M Scheidter, Julia Monk, Forrest I Whiting, Nadeshka J Ramirez-Perez, Deanna M Barch, Aristeidis Sotiras, Nico U F Dosenbach

2020-Current year OA Pubs

Understanding sex differences in the adolescent brain is crucial, as they relate to sex-specific neurological and psychiatric conditions. Predicting sex from adolescent brain data may reveal how these differences influence neurodevelopment. Recently, attention has shifted toward socially-identified gender (distinct from sex assigned at birth) recognizing its explanatory power. This study evaluates whether resting-state functional connectivity (rsFC), cortical thickness, or cortical volume better predicts sex and sex/gender alignment (congruence between sex and gender) in preadolescents. Using Adolescent Brain Cognitive Development (ABCD) Study data and machine learning, rsFC predicted sex more accurately (85 %) than cortical thickness (76 %) and cortical volume …

Ai Procurement As Regulatory Reconnaissance, Sam Adler

Fordham Law Review

Artificial intelligence (AI) is a black box technology in a black box industry. Some view AI as a life-changing technology capable of advancing society and perhaps even saving the world, while others fear its capacity to harm. Like Dr. Frankenstein, developers fear the unpredictability of their own creations; deployers fear the unknown risks of third-party AI tools that market pressures drive them to assume; members of civil society fear AI’s capacity to oppress the already oppressed and degrade trust in institutions; and everyday users fear the undisclosed potential of AI to cause harm by means they cannot readily comprehend. These …