Digital Commons Network^™

Hkc02 - Stabilizing Credit When Nonperforming Loans Surge: The Role Of Asset Management Companies, Reiner Martin, Edward O'Brien, M. Udara Peiris, Dimitrios P. Tsomocos

Oberlin College Kasper Economics and Business Working Paper Series

When default losses elevate borrowing costs, expanding credit cannot stabilize the economy because default rates feed back to lending rates through bank balance sheets. Asset management companies (AMCs) break this loop by purchasing nonperforming loans at their long-run recovery values, thereby fixing the effective default rate that banks face. Government purchases of performing loans expand credit but leave this feedback intact. In a model calibrated to the eurozone, the AMC reduces quarterly default rates by 0.8 percentage points, lowers lending rates by 1.6 percentage points, and raises welfare by 0.2%. Government purchases crowd out bank deposits, contracting credit; default rates …

Early Peripheral Blood Gene Expression Predicts 90-Day Outcomes Following Subarachnoid Hemorrhage, Bodie Knepp, Garreck H Lenz, Frank R Sharp, Fernando Rodriguez, Huimahn Alex Choi, Aaron M Gusdon, Glen Jickling, Lara L Zimmermann, Ryan Martin, Jeffrey Vitt, Ben Waldau, Brandon J Cord, Alan Yee, Kwan Ng, Nerissa U Ko, Heather Hull, Bradley P Ander, Boryana Stamova

Faculty, Staff and Student Publications

BACKGROUND: Previous clinical, radiological and machine learning studies have predicted 90-day outcomes following subarachnoid hemorrhage (SAH). The present study was designed to determine whether early changes in mRNA expression of immune, clotting and other genes expressed in peripheral blood can predict patient outcomes at 90 days after SAH and possibly provide insights into the molecular factors that promote good versus poor outcomes.

METHODS: Peripheral blood was drawn after SAH and from vascular risk factor controls (VRFC) and RNAseq performed to measure mRNA expression. A mixed effects regression model identified potential predictors and machine learning algorithms derived the best predictors of …

Bayesian Learning To Reduce Cardiac Risk Of Patients With Locally Advanced Non-Small Cell Lung Cancer Based On Personalized Radiation Therapy Prescription, Ruitao Lin, Mei Chen, Xiaodong Zhang, Tianlin Xu, Ting Xu, Rachel C Maguire, Kelsey L Corrigan, Efstratios Koutroumpakis, Joe Y Chang, Steven H Lin, Aileen B Chen, Quynh-Nhu Nguyen, Saumil J Gandhi, Matthew S Ning, Julianna Bronk, Stephen Chun, Ali Ajdari, Joshua S Niedzielski, Jinzhong Yang, Xinru Chen, Tinsu Pan, Qing H Meng, Anne S Tsao, Anita Deswal, Radhe Mohan, Zhongxing Liao

Faculty, Staff and Student Publications

Purpose: Radiation-induced heart damage is a significant concern in the treatment of non-small cell lung cancer (NSCLC) that can have debilitating or life-threatening consequences. Current strategies focus on minimizing heart exposure, but individual susceptibility varies. Existing evidence also suggests that a uniform "one-size-fits-all" dosimetric constraint for the heart may not be optimal for all patients.

Methods and materials: We developed a prospective study using Bayesian continuous learning and adaptation to develop a framework for personalized adaptive radiation treatment (PART) to reduce cardiovascular adverse events among patients with locally advanced NSCLC. The trial includes a Bayesian personalized risk prediction model to …

Health-Related Quality Of Life In The Era Of Immune Checkpoint Blockade: What Do Patient-Reported Outcomes Reveal?, Alexandra M Dunker, Neha Malik, Kathryn J Krause, Emily Z Keung, Jason B Liu, Elise F Nassif Haddad, Neeta Somaiah, Heather G Lyu, Christina L Roland

Faculty, Staff and Student Publications

Background: Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment by providing durable survival gains, but understanding their effects on patient health-related quality of life (HRQL) is critical.

Methods: We performed a narrative review of cross-sectional surveys, early-phase trials, and large-scale phase II and III randomized controlled clinical trials assessing FDA-approved ICIs, including programmed cell death protein 1 (PD-1) inhibitors, programmed death ligand 1 (PD-L1) inhibitors, and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) inhibitors, with emphasis on patient-reported HRQL. Validated HRQL instruments were summarized, and for pivotal trials, the positioning of HRQL outcomes as primary, secondary, or exploratory endpoints was taken …

A Review Of Recent And Developing Studies Regarding Percutaneous Coronary Intervention (Pci): A Narrative Review, Bisher Alsabbagh, Azeez Shala, Joshua Rupert, Abdallah Elsayed

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)

This comprehensive literature review synthesizes the most recent evidence and evolving clinical guidelines concerning percutaneous coronary intervention (PCI) from 2015 to 2025. The study integrates findings from 42 peer-reviewed trials, meta-analyses, registries, and international guideline statements issued by the American College of Cardiology/American Heart Association (ACC/AHA), European Society of Cardiology (ESC), and related societies. Results reveal a decade-long evolution in PCI practice marked by a shift from anatomy-driven to physiology and imaging-guided decision-making, supported by tools such as fractional flow reserve (FFR), instantaneous wave-free ratio (iFR), intravascular ultrasound (IVUS), and optical coherence tomography (OCT). Modern guidelines emphasize individualized, team-based revascularization …

Endothelial-Derived Extracellular Vesicles During Exercise In Copd Patients, Samuel C Okpechi, Dorota Wyczechowska, Bennett Deboisblanc, Jessica L Johnson, Mohamed A Ghonim, Natalie Bauer, Hamid A Boulares, Matthew R Lammi

School of Medicine Faculty Publications

Introduction: There are no treatments directly targeting the pulmonary vasculature in chronic obstructive pulmonary disease (COPD), and further characterization of the underlying endothelial cell (EC) abnormalities could be helpful in drug development. Methods: We investigated the influence of exercise and the prostacyclin analog iloprost on extracellular vesicles derived from ECs (eEVs) in 15 moderate–severe COPD patients who were enrolled in a randomized, placebo-controlled crossover trial of iloprost. Results: Active smokers had a profile consistent with inflammatory-derived EVs, while exacerbation-prone COPD subjects had a profile consistent with apoptosis-derived eEVs. There were no significant effects of iloprost on eEV levels. However, there …

Simulating Sustainability: How Resorts Can Balance Freshness And Waste In Produce Supply Chains, Isabella M. Camberos

Sustainable Supply Chain Management

Resorts face increasing pressure to reduce food waste while maintaining high levels of service quality and produce freshness. This study examines how discrete-event simulation can be used as a decision tool to analyze and improve produce supply chains in the hospitality industry. A simulation model was developed in Simio to compare local and global produce sourcing strategies under identical demand, storage capacity, and spoilage conditions. The model captures key system characteristics, including batch-based deliveries, cold storage constraints, perishability, and probabilistic guest waste. Results indicate that while both sourcing strategies exhibit efficient flow and minimal congestion, global sourcing generates significantly higher …

Executive Function Among Older Adults With Bipolar Disorder: A Gage-Bd Analysis, Federica Klaus, Martha Sajatovic, Peijun Chen, Nicole Fiorelli, Ashley N. Sutherland

Faculty Scholarship

Objectives Executive function deficits in bipolar disorder (BD) are major contributors to disability in older age BD (OABD). We investigated the difference between OABD and age-equated healthy comparators (HC); and, in the OABD group, the associations of executive function with age, symptom severity, global cognition, and daily functioning. Design Cross-sectional analysis of executive function in OABD versus HC. Setting Analysis of large archival dataset harmonized from 12 international OABD studies. Participants Older adults (≥50 years) with OABD ( n = 614) and HC ( n = 192). Measurements Executive function was assessed via Trail Making Test B (TMT-B) completion time; …

Personalized Perioperative Opioid Strategies In Children: Focus On Methadone, Pharmacogenomics And Prevention Of Persistent Postoperative Opioid Use, Hamsa Priya Bhuchakra, Sennaraj Balasubramanian, Alivia G Nair, Isabella Marcos, Victoria Chen Falconett, Dominic Falcon, Ayesha Abdul Bari, Senthilkumar Sadhasivam

2020-Current year OA Pubs

Persistent postoperative opioid use (PPOU) is an emerging challenge in pediatric perioperative care, with rates as high as 4.7% in opioid-naive adolescents. Despite advances in multimodal analgesia, current protocols often fail to prevent long-term opioid exposure, particularly after high-risk surgeries such as spinal fusions. While multiple strategies exist to reduce PPOU in children, including regional anesthesia and non-opioid analgesics, this review specifically focuses on methadone and pharmacogenomic-guided opioid prescribing as promising approaches. Methadone, a long-acting opioid with mu-opioid agonism, NMDA antagonism, and monoamine reuptake inhibition, has shown encouraging outcomes in adult and emerging pediatric studies but remains underutilized due to …

Anticonvulsant Activity Of Simvastatin On Experimentally Induced Epileptic Seizures In Mice, Uday Abdul-Reda Hussein, Nargis Amer Nayef, Baneen Adel Abdul-Hussein, Tamara Hassan Mawazi, Zahraa Kadhim Hussein, Noor Alhuda Ali Saadon, Zainab Mohammed Abd, Fatima Mohammed Alwan, Huda Bassim Latif, Hassanein Mohammed , Razak, Mohammed Rida Majeed, Mohammed Abdul-Elah Abdul-Hamid

Al-Ameed Journal for Medical Research and Health Sciences

Background: Epilepsy is a common neurological disorder characterized by recurrent seizures. Simvastatin was recognized as a new candidate that exhibits a variety of neuroprotective effects, including antioxidant and anti-inflammatory effects that have the ability to inhibit neuronal hyperexcitability and seizure susceptibility.

Aim: The purpose of this study is to assess the possible anticonvulsant action of simvastatin in the mouse seizure model.

Material and Methods: The eighteen adult albino mice (25–30 g) were allotted randomly to three groups (n = 6). Thirty minutes before the induction of convulsion, the groups received different intraperitoneal pretreatments: Group 1: Distilled water (0.1 ml), Group …

Measuring Levels Of Ultrashort-Chain Per- And Polyfluoroalkyl Substances In Blood Collection Tubes, Alina M. Dziembowski

Discovery Undergraduate Interdisciplinary Research Internship

Per- and polyfluoroalkyl substances (PFAS) are highly persistent synthetic chemicals that are now ubiquitous in the environment. Due to PFAS stability leading to its environmental persistence, there is concern regarding potential long-term health effects as PFAS accumulation occurs in humans from dietary and inhalation exposure routes. Chronic exposure may lead to adverse effects such as fertility issues or liver damage. Although a wide range of PFAS have been found in human samples, specifically human serum, there remains data gaps for what PFAS are present in human blood. Recent innovation in detection technology has led to the ability to more accurately …

Examining The Intersectional And Structural Issues Of Routine Healthcare Utilization And Access Inequities For Lgb People With Chronic Diseases, Shiya Cao, Mehreen Mirza, Sophia Silovsky, Nicole Tresvalles, Lucia Qin, Sarah Susnea

Statistical and Data Sciences: Faculty Publications

In the United States, although the gaps in health insurance coverage by sexual orientation have been closing since the implementation of the Affordable Care Act and legalization of same-sex marriage, the LGB group (i.e., lesbian, gay, bisexual) continues to report healthcare utilization and access inequities such as more delayed or unmet care. The extant research has often examined healthcare utilization and access inequities due to affordability (e.g., out-of-pocket costs). However, healthcare utilization and access inequities are only partially explained by cost reasons; there are non-cost reasons that have not been adequately empirically examined. The present study innovatively includes discrimination structural …

The Safety Kuznets Curve: Context In Occupational Safety, Andy Knickerbocker

ASEM Capstones

2025 ASEM 620 Capstone Project

Foundation Gift Benefits Children's Health Care, Bill Dabney

University of Mississippi News

OXFORD, Miss. – Some patients at Children's of Mississippi being treated for a craniofacial syndrome, cleft lip and palate or another craniofacial abnormality stand to benefit from a recent gift to the University of Mississippi Medical Center.

Toward Indonesia’S Zero Leprosy 2030: Key Lessons From Epidemiological Trends In Papua 2020-2024, Inneke Viviane Sumolang, Dimas Iqbal Romadhon, Agnes Angelita Suyanto

Folia Medica Indonesiana

Papua, the easternmost province of Indonesia, has consistently reported the highest number of new leprosy cases and leprosy-related disabilities for decades. Despite this burden, no comprehensive study in recent years has systematically examined the epidemiological trends of leprosy in Papua using large datasets. This study provides an updated analysis of leprosy elimination efforts and evaluates the province’s readiness to achieve the Zero Leprosy 2030 target. A retrospective descriptive epidemiological review was conducted using secondary data from the routine health information system of Papua Province from 2020 to 2024. Extracted variables included demographic characteristics, new case reports, diagnostic classification, disability grade, …

State Of California Cannabis Reporting, University Of Mississippi – National Center For Cannabis Research And Education

California

No abstract provided.

Hardships Increase As Households Rely More On Gig Work, Laura Brugger, Anthony J. Nixon, Amrita Kulkarni, Mathieu Despard, Stephen Roll

Center for Social Development Research

Gig work has grown substantially in the United States in recent years. Although research has examined the relationship between participation in the gig economy and hardship, few studies examine how households’ reliance on gig work relates to hardship experiences. Drawing upon data from the Workforce Economic Inclusion and Mobility survey of a nationally representative sample of low-wage workers, this brief explores the relationship between the proportion of a household’s income from gig work and indicators of financial distress: bill payment difficulties, food insufficiency, budget constraints, blood plasma sales, reliance on alternative financial services such as payday loans, and usage of …

Experiences Of Non-Hispanic Black And African American Women With Postpartum Healthcare, Margaret F. Sposato, Claire Draucker, Jasmine D. Johnson, Kristin Tully, Julie Otte

Biennial Convention (CONV)

Racial and ethnic disparities in maternal mortality and morbidity are stark in the United States, especially for non-Hispanic Black and African American women who experience elevated rates of pregnancy-related deaths and severe maternal morbidity.^1,2 Effective postpartum healthcare is essential for optimizing birthing people’s health,³ yet little is known about non-Hispanic Black and African American women’s experiences with postpartum healthcare in the year following delivery. The purpose of this study was to describe non-Hispanic Black and African American women’s experiences with postpartum healthcare throughout the one-year postpartum period from their perspectives. For this qualitative descriptive study semi-structured interviews with …

Closeness, Conflict, And Achievement: The Role Of Parent–Child Relationships In Homeschooled And Public-Schooled Children, Celeste Gonçalves Tomaz

Honors Capstones

The parent–child relationship has been found to be a predictor of children’s academic and socio-emotional outcomes, with parent-child closeness linked to motivation and persistence (Mo & Singh, 2008; Silinskas & Kikas, 2022) and parent-child conflict associated with emotional and behavioral difficulties (Dotterer et al., 2008; Pinquart, 2017). The homeschooling context may increase these associations since children spend more time with their parents, who have caregiving and instructional roles (Padilla, 2021; Thomas, 2016). Even with growing research on academic and socio-emotional outcomes, few studies have examined whether the strength of the parent–child relationship is influenced negatively or positively by schooling type. …

Technology, Education, Access, Communities And Healthcare: Teach Toward A Healthy Rural Wisconsin, Kathleen Abrahamson, Debbie Walrath, Shanon Brickner, Christine Davidson, Heidi Hansen, Seon Yoon Chung

Biennial Convention (CONV)

Purpose statement: The purpose of this project is to educate the future nursing workforce on tele-healthcare delivery skills that will reduce barriers to care and improve rural chronic illness outcomes in Wisconsin.

Background: Nearly one-third of Wisconsin citizens reside in rural areas (Wisconsin Policy Forum, 2023). Rural Wisconsinites are disproportionately at risk for adverse health outcomes (Rural Health Information Hub, 2023). A lack of available healthcare services and providers in rural Wisconsin compounds this risk. All non-metropolitan counties in Wisconsin experience a shortage of primary care providers (U.S. Department of Health & Human Services, 2023). Nurse-supported telehealth services provide a …

Changing Opinions: The Supreme Court After Dobbs, Lora E. Judge

Honors Theses

No abstract provided.

The Reception Of Neurodiversity Represented Within Netflix’S Wednesday, Anna Stevens

Graduate Theses & Dissertations

This paper explores how neurodiversity is represented through popular media - particularly Netflix's show Wednesday - and aims to discuss the effects this representation could have in regards to how it's received by the public, as well as those who are neurodiverse.

Proteome-Wide Association Study Of Prostate Cancer Risk Across Populations, Hua Zhong, Jingjing Zhu, Shuai Liu, Chong Wu, Liang Wang, Seamus P. Whelton, Catherine H. Marshall, Michael J. Blaha, Peter Durda, Xiuqing Guo, Craig W. Johnson, Henry J. Lin, Kent D. Taylor, Russell P. Tracy, Ronit I. Yarden, Ani W. Manichaikul, Stephen S. Rich, Jerome I. Rotter, Rajat Deo, Ruth F. Dubin, Peter Ganz, Lang Wu

School of Graduate Studies Faculty Publications

There is insufficient understanding of the molecular basis of prostate cancer (PCa) across different populations. We perform a large-scale proteome-wide association study (PWAS) to identify proteins with genetically regulated expression in plasma to be associated with PCa risk across populations. We develop genetic prediction models for expression of 1578, 1993, 1218, and 1390 proteins for African (n = 450), European (n = 758), Asian (n = 289), and Hispanic/Latino (n = 474) males, respectively, and evaluate associations of genetically regulated protein expression with PCa risk in 19,391 PCa cases and 61,608 controls of African population, 122,188 cases and 604,640 controls …

Using Mean Airway Pressure (Map) As An Indicator To Help Predict Successful Extubationof Preterm And Term Infants In A Neonatal Intensive Care Unit, William F. Bucher, Rrt-Nps, Eliza C. Desantis, Md

Division of Pulmonary, Allergy, and Critical Care Medicine Posters

Background
Extubation of preterm and term infants in a neonatal intensive care setting has always proven to be a challenge often resulting in failure. One of the challenges to a successful extubation in this vulnerable patient population is maintaining proper lung inflation at the time of extubation. We often rely on the use of the mean airway pressure (MAP) as an indicator to help predict patient readiness to extubate these patients.

Methods
23 patients ranging from 24 weeks to 41 weeks corrected gestational age were extubated from either conventional mechanical ventilation (CMV) or high frequency ventilation (HFV) using their mean …

Operationalizing Flourishing In Bsn Nursing Education: A Cipp- Driven Strategy, Kennedy E. Hochstedler, Elizabeth Morse

DNP Projects

Operationalizing Flourishing in BSN Nursing Education: A CIPP- Driven Strategy

Double Burden Stress In Women And The Role Of Psycho-Religious Worship In Alleviating It, Fahmi Mandala Putra, Zata Ismah, Rizky Indah Syahfitri, Citra Cahyati Nasution, Az-Zahra Atika Putri, Fitria Amirah, Tri Amelia Rahmitha Helmi

Folia Medica Indonesiana

It has been recognized that women are twice as likely to experience depression compared to men. In addition to biological vulnerability, there is also a combined effect of bearing the burden of household responsibilities while contributing financially through employment. One coping strategy that helps women endure these challenges is meditation, which in Islam includes the practice of dhikr (remembrance of God). This study aims to analyze the phenomenon of double burden stress in women and how psychoreligious practices can help reduce stress levels. The study employed a prospective cohort design, tracking the respondents' dhikr habits over a 21-day period. On …

Innovative Offshore Transition-To-Practice Model For International Nurses Using Tele-Simulation, Lisa Mceathron, Christian Striggow, Jose Arnold Tariga

Biennial Convention (CONV)

Empirical evidence underscores the importance of optimal nurse staffing in delivering high-quality patient care, improving outcomes, and enhancing nurse well-being. Internationally educated nurses (IENs) play a crucial role in addressing staffing shortages in the United States, yet they face challenges in bridging gaps between varying international nursing standards and US healthcare practices. Innovative approaches are essential to ensure their readiness to integrate effectively prior to arrival.

The International Transition to Practice Program leverages tele-simulation as a pioneering strategy to address these challenges, providing an offshore, immersive learning experience for IENs. This program was implemented from July 2023 to September 2024, …

Improving Hiv Knowledge And Attitudes Of The Youth In The Philippines Through Mobile Text Messaging, James Montegrico

Biennial Convention (CONV)

Background: The Philippines has the highest HIV incidence rate in the Asia-Pacific region, with the highest incidence between the ages 15 to 34 years. There are low levels of HIV knowledge, negative attitudes towards people with HIV/AIDS, and a lack of interventional studies to improve HIV knowledge and attitudes in the country. The high rate of mobile phone use and text messaging in the Philippines offers potential in using technology to address gaps in HIV knowledge and negative attitudes regarding HIV.

Purpose: This pilot study determined the feasibility and effectiveness of mobile text messaging (MTM) in improving HIV/AIDS knowledge …

Enhancing Pediatric Emergency Medication Safety With Nurse-Led Innovation And Technology, Lindsey Catterson, Jessica Revet, Zainab Alzawad

Biennial Convention (CONV)

Purpose: Ensuring the safe handoff of controlled substances during patient transfers is critical in pediatric emergency care. Recognizing gaps in documentation and chain-of-custody processes, this nurse-led initiative aimed to design an innovative, technology-driven approach to enhance patient safety and ensure compliance with regulatory standards. The project focused on integrating advanced tools to streamline workflows, minimize errors, and safeguard pediatric patients.

Methods: A multidisciplinary team, led by pediatric emergency nurses, collaborated to develop a documentation framework leveraging existing health technology. The team adapted the Epic Rover mobile application and electronic medical record (EMR) systems to enable real-time documentation of …

A Mobile Meditation Application To Impact Nursing And Nursing Student Stress, Lisa Corry

Biennial Convention (CONV)

Nurses care for all members of the community and are expected to be representatives of good health. They often place the needs of their patients before their own while they are faced with a variety of stressful situations and working environments (Linton & Koonmen, 2020). Nurses experience high levels of stress which can have negative effects on an individual. Over time, untreated stress for nurses may lead to burnout or compassion fatigue which has been associated with poor patient outcomes, decreased patient satisfaction, and high attrition rates (Bonamer & Aquino-Russel, 2019). This can result in increased costs related to callouts, …