Digital Commons Network^™

Assessing The Function Of The Alternative Electron Transport Chain In The Cryptosporidium Parvum Mitosome, Silu Deng, Wandy Beatty, L David Sibley

2020-Current year OA Pubs

UNLABELLED:

IMPORTANCE: Cryptosporidiosis is a leading cause of diarrhea in young children and immunocompromised individuals, particularly AIDS/HIV patients. The only FDA-approved drug against cryptosporidiosis, nitazoxanide, has limited effectiveness in immunocompromised patients and is not approved for use in children under 1 year. Genomic analysis and previous studies proposed an alternative respiration pathway involving alternative oxidase (AOX) and type II NAD(P)H dehydrogenase (NDH2), which are thought to generate the mitosome membrane potential in

Patent Searching With Uspto, Derwent Innovation And Lens.Org, Ibis Anette Moreno-Lozano

Day Family Research Lab Workshop Series

No abstract provided.

High School Science Experience For Students With Cognitive Disabilities: A Pilot Study, Cassandra Wychers

Honors Theses

Although education has become more adaptive, inclusive of all students who learn differently including for people with cognitive disabilities, closer examination may reveal that high school science classrooms are still challenging learning spaces. Science is an important part of the school curriculum as it teaches students about engaging in the world around them while also encouraging skills involving evidence, inquiries, and critical thinking. All students are entitled to learn science in their classrooms even if they have a cognitive disability (Apanasionok, et al. 2019). Although there are many complexities to defining disability in the world and in education, this study …

The Impact Of Discontinuation And Non-Publishing Of Osteoporosis Clinical Trials, Daxton Kennington, Andrew Simonsen, Whitney Shae, Catherine L. Satterwhite

Student Publications

Context: Osteoporosis is a prevalent chronic disease associated with fractures, reduced quality of life, and substantial healthcare costs. Randomized controlled trials (RCTs) are essential for developing effective treatments, but when trials are discontinued or unpublished, valuable data are lost. This results in unnecessary costs and exposes thousands of participants to interventions without contributing to clinical care.

Objectives: This study aims to evaluate the rates and characteristics of discontinuation and nonpublication among US-registered phase 3 and 4 RCTs investigating osteoporosis therapies from 2000 to 2022.

Methods: Phase 3 and 4 osteoporosis-related RCTs were identified through ClinicalTrials.gov. Trial completion and publication status …

A Canadian Advanced Physiotherapist Practitioner Shared-Care Model In Pediatric Rheumatology Offers Safe And Quality Care In The Management Of Juvenile Idiopathic Arthritis-Comparing Key Performance Indicators With The Pr-Coin Registry., Julie Herrington, Patrick Clarkin, Jade Singleton, Karen Beattie, Sheetal S. Vora, Katelyn Banschbach, Catherine A. Bingham, Tania Cellucci, Danielle Fair, Mileka Gilbert, Beth Gottlieb, Julia G. Harris, Liane Heale, Tzielan Lee, Melissa L. Mannion, Edward J. Oberle, Nancy Pan, Jonathan Park, Mary Toth, Jennifer E. Weiss, Michelle Batthish, Pediatric Rheumatology Care And Outcomes Improvement Network

Manuscripts, Articles, Book Chapters and Other Papers

Background/Objectives: Canadian Advanced Physiotherapist Practitioner (APP) roles have existed for over 25 years in pediatric rheumatology. The APP can manage many common pediatric rheumatic conditions most often in Shared-Care Models (SCMs) with pediatric rheumatologists (PRs). The quality of care children receive in an APP SCM compared to traditional care is unknown. The Pediatric Rheumatology Care and Outcomes Improvement Network (PR-COIN) tracks quality measures as Key Performance Indicators (KPIs) in juvenile idiopathic arthritis (JIA) care. This study aimed to analyze the frequency of KPIs documented in a pediatric rheumatology APP SCM from a single center and compare to PR-COIN's performance …

Presentation, Diagnosis, And Acute Treatment Of Secondary Hemophagocytic Lymphohistiocytosis: A Case Report, Alexandra Bartholomew, Michael Connick, Catherine Loehr, Shane Sanne

School of Medicine Faculty Publications

Secondary hemophagocytic lymphohistiocytosis (HLH) is a rare, immunologically driven disorder with a high mortality rate. It is typically diagnosed on the basis of clinical and laboratory criteria. We present the case of a 53-year-old woman with multiple previous hospitalizations for fever of unknown origin and fatigue. Her workup ultimately led to a diagnosis of HLH. We discuss the presentation, diagnostic criteria, and clinical treatment of secondary HLH to guide workup and management for future patients affected by this rare disease.

Electrochemical Detection Of Aβ42 And Aβ40 At Attomolar Scale Via Optimised Antibody Loading On Pyr-Nhs-Functionalised 3d Graphene Foam Electrodes, Muhsin Dogan, Sophia Nazir, David Jenkins, Yinghui Wei, Genhua Pan

School of Engineering, Computing and Mathematics

Alzheimer’s Disease (AD) is one of the most commonly seen neurodegenerative disorders, where early detection of its biomarkers is crucial for effective management. Conventional diagnostic methods are often expensive, time-consuming, and highly complex, which highlights an urgent need for point-of-care biosensing technology. In this work, we developed assays on three-dimensional (3D) graphene foam electrodes by functionalising them with a 1-Pyrenebutyric acid N-hydroxysuccinimide ester (Pyr-NHS) to enable effective antibody immobilisation for the detection of amyloid beta peptides (Aβ42 and Aβ40), key biomarkers for AD. Pyr-NHS linkers were used for stable functionalisation, followed by binding with Aβ42 and Aβ40 antibodies, and then …

Fall 2025 Issue Co-Editor Letter, Cambria Sheridan, Mckenzie M. Lemhouse

South Carolina Libraries

No abstract provided.

A Conversation With Paolo Lugari, Founder Of Las Gaviotas, Colombia, Jonathan Andelson

Communal Societies

No abstract provided.

Ananda And The World Brotherhood Communities Movement, Prisha Kirby

Communal Societies

No abstract provided.

King’S Wigwam: Atlanta’S Forgotten Black Summer Resort, Andrew J. Bramlett, Seneca Vaught

Symposium of Student Scholars

From 1915 to 1920, the only summer resort for Black Atlantans was King’s Wigwam, located north of the small farming community of Kennesaw. Situated on over forty acres owned by Auburn Avenue entrepreneur Cornelius King, the summer resort saw a host of notable visitors during its short five years of existence. During the 1919 season, a guest named Bertram Hamilton was falsely accused of rape in nearby Cherokee County. He was taken to the county jail as an angry mob gathered. The county sheriff, who had been part of the mob that lynched Leo Frank four years before, believed Hamilton …

Defining The European Union’S Top Public Health Priorities: What Can Be Gleaned From Its Multi-State Interdisciplinary Systems?, Mattie Frascella, Thierry Leger

Symposium of Student Scholars

Delineation of the European Union’s (EU) contemporary public health agenda is examined within the evolving architecture of a ‘European Health Union.’ Five interdependent domains are synthesized: climate and planetary health, digital transformation, resilient systems and workforce development, non-communicable disease (NCD) prevention, and cross-sectoral and global leadership. Mutual reinforcement is essential for achieving equitable outcomes. The climate pillar reframes environmental disruption as a public health emergency, embedding adaptation, mitigation, and Planetary/One Health approaches across EU initiatives. The digital pillar examines the European Health Data Space and adjacent tools (telemedicine, e-prescribing, mobile health) as infrastructure for secure interoperability, research, and quality improvement. …

Review Of Thin Description: Ethnography And The African Hebrew Israelites Of Jerusalem, Emily Suzanne Clark

Communal Societies

No abstract provided.

Being The Change: Food, Nonviolence, And Self-Sufficiency In Contemporary Intentional Communities, A. Whitney Stanford

Communal Societies

No abstract provided.

Supporting Best Practices In Family Engagement: Our Week Of The Young Child Experience, Michelle Fazio Brunson, Faith S. Birdwell, April Giddens

Spark! Innovations in Early Childhood Education: A Research-to-Practice Journal for Educators

Family engagement is a collaborative process where early childhood professionals, families, and children build positive, goal-oriented relationships. Incorporating family engagement into preschool programs is not merely beneficial but essential for promoting holistic child development in programs where children feel safe, cared for, and secure. In this article, we share the benefits of effective family engagement activities for families with young children and describe how we celebrated the National Association for the Education of Young Children's 2025 Week of the Young Child.

Using Food As A Fun And Effective Teaching Tool In Preschool, Kelly Furr, Melani Duffrin, Eugene A. Geist

Spark! Innovations in Early Childhood Education: A Research-to-Practice Journal for Educators

Food is one of the most engaging, hands-on materials for preschool classrooms. This article highlights research from the Food FAN Academy (Furr, 2023), which demonstrates how food can be used as a teaching tool across early childhood learning environments. Practical strategies are provided for preschool teachers, including detailed lesson plans that connect to early math, science, literacy, and social development. The article emphasizes the importance of using everyday materials, cultural inclusivity, and active learning methods to promote curiosity, health awareness, and foundational skills in young learners.

Abcs Of Behavior: Strategies To Effectively Reduce Challenging Behaviors, Sarah Matthews

Spark! Innovations in Early Childhood Education: A Research-to-Practice Journal for Educators

This paper explores the application of the ABC (Antecedent-Behavior-Consequence) model and functional behavior assessments (FBAs) to understand and manage challenging behaviors in early childhood education settings. Grounded in developmental theory and informed by professional experience as an early interventionist, the paper emphasizes the importance of identifying behavioral triggers and using individualized, developmentally appropriate strategies. The role of collaboration among teachers, families, and specialists is highlighted as essential for consistent and effective intervention. Key strategies discussed include coaching caregivers, embedding interventions within natural classroom environments, and using positive, non-punitive approaches to time-out. The paper advocates for proactive, respectful behavioral guidance practices …

Letter From The Editor, Cynthia Dicarlo

Spark! Innovations in Early Childhood Education: A Research-to-Practice Journal for Educators

No abstract provided.

The Effects Of Emodepside On L1 C. Elegans, Mehrael Louza, Ismail Mustafa, Judiah Ward, Marina Khalif

Student Scholar Symposium

Soil-transmitted helminths (STHs) infect approximately 1.5 billion humans worldwide. These parasites include Ascaris lumbricoides, Trichuris americanus, and Ancylostoma duodenale which primarily infect inhabitants of tropical and subtropical areas, where access to clean resources such as water and sanitation is insufficient. Infected individuals experience malnutrition, impaired cognitive function, immune dysregulation, and many other health consequences that persist (Hotez, et al., 2004). These effects prevent individuals from thriving and trap them in poverty. The World Health Organization (WHO) has authorized the use of four drugs for mass distribution to combat the infections. However, despite the existence of effective drugs, concerns over drug-resistance …

The Analysis Of Ellen White’S Writings Regarding Personal Power As Applied To The Hagberg Model Of Leadership And Power, Stanley E. Patterson

Ellen White Issues Symposium

No abstract provided.

Creating A Decision-Making Curriculum For Students With And Without Disabilities In Grades P-12, Gina Riley, Elizabeth Klein, Alfonso Perez, Imani Irving Perez, Adriana D. Nathan

Excelsior: Leadership in Teaching and Learning

No abstract provided.

Learning To Love Science: Preservice Elementary Teachers Conceptualizations Of Science Teaching And Self-Efficacy To Teach Science, Christine Mcgrail, Stephanie B. Purington, Alicia Gonzales

Excelsior: Leadership in Teaching and Learning

No abstract provided.

The Early Translation Of Ellen G. White Books Into Spanish, Gluder Quispe

Ellen White and Current Issues Symposium

No abstract provided.

The Phenomenon Of Prophecy And Role Of Prophets In The Old Testament Compared With The Ministry Of Ellen G. White, Jiří Moskala

Ellen White and Current Issues Symposium

No abstract provided.

Gift Of Prophecy And The Church: A Biblical Perspective, Ranko Stefanovic

Ellen White and Current Issues Symposium

No abstract provided.

Responding To The Vision Of 1856: How Adventists Have Understood And Explained Its Message, Tim Poirier

Ellen White and Current Issues Symposium

No abstract provided.

The Homes Of James And Ellen White, Stanley D. Hickerson

Ellen White and Current Issues Symposium

No abstract provided.

Ellen White And Environmental Ethics, Joann Davidson

Ellen White and Current Issues Symposium

No abstract provided.

Purification Of Water By Plant Extracts And Green Biosynthesized Agnp Of Syzygium Aromaticum, Seham Abdel-Shafi, Mostafa I. Abdelglil, Saida Amer, Sobhy El Sawy Elsilk, Khaled Ali, Mohamed F Ghaly

Al-Farahidi Biomedical Journal

The drinking water quality must meet both the WHO guidelines and Egyptian standards. This ensures public health and the suitability of water for different uses. The purification of water by biosynthesized silver nanoparticles (AgNPs) Syzygium aromaticum (Clove) is an eco-friendly approach where the clove extract acts as a reducing and stabilizing agent to create AgNPs through a “green synthesis” method. The AgNPs, when combined with the extract, show antimicrobial activities and kill the pathogenic bacteria in water. The water pollution include Staphylococcus, Pseudomonas, Salmonella, Acinetobacter, Flavobacterium, Clostridium, Vibrio and E. coli. In vitro experiments showed inhibition of Staphylococcus spp. …

Improving Road Safety Through Multimodal Deep Learning For Driver Drowsiness Detection, Hadel A. Hussain, Mohammed A. Subhi, Ahmed S. Al Tmeme, Ahmed D. Radhi, Marwan Ali Albahar

Iraqi Journal for Computer Science and Mathematics

One of the most common causes of road accidents globally is driver drowsiness and it needs solutions that are reliable and can be applicable in numerous real-life situations. We present this paper with the aim of developing a deep-learning system that is capable of reliably detecting drowsiness in diverse and varied conditions across different drivers, environments, and sensor types. Our system is known as Multimodal Attention Network (MMAN), which combines information of eye and head movement, heart-rate and breathing pattern, and vehicle-dynamics signal. MMAN has a gradient-reversal layer that enables the layer to be domain-adaptive such that it does not …