Digital Commons Network^™

Effects Of Endocrine Disruptors On Thyroid Hormone Synthesis And Function And Consequences Of Fetal Exposure, Esra Eraslan Aydemi̇r, Mustafa Şahi̇n

Turkish Journal of Medical Sciences

Fetal development relies on intricate maternal-fetal-placental interactions, with thyroid hormones playing a critical role in growth and neurogenesis. Exposure to endocrine-disrupting chemicals (EDCs) during pregnancy has emerged as a significant risk factor for thyroid dysfunction and its associated developmental and cognitive disorders. EDCs, including bisphenol A (BPA), polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), perfluorinated compounds (PFAS), pesticides, and heavy metals, disrupt thyroid hormone synthesis, secretion, and metabolism. Mechanisms include binding to thyroid hormone receptors, impairing the hypothalamic-pituitary-thyroid axis, and altering thyroid peroxidase activity. BPA exposure, for instance, reduces free and total T4 levels and interferes with deiodinase activity. Similarly, …

Her2-Low And Her2-Ultralow Metastatic Breast Cancer And Trastuzumab Deruxtecan: Common Clinical Questions And Answers, Nusayba A Bagegni, Karthik V Giridhar, Daphne Stewart

2020-Current year OA Pubs

Approximately 80% of invasive breast cancers are classified as human epidermal growth factor receptor 2 (HER2)-negative; however, many of these tumors have detectable levels of HER2 surface expression. Trastuzumab deruxtecan (T-DXd) is a HER2-directed antibody-drug conjugate with a membrane-permeable payload that is cytotoxic to both HER2-expressing tumor cells and neighboring cells via the bystander antitumor effect. T-DXd has shown significant antitumor activity in clinical trials for patients with HER2-positive (immunohistochemistry [IHC] 3+ or IHC 2+/in situ hybridization [ISH]+) breast cancer. In addition, the results of the DESTINY-Breast04 trial demonstrated the clinical benefit of T-DXd in patients with HER2-low (IHC 1+ …

2025-12-17 University Graduate Committee Meeting Minutes, Morehead State University. Faculty Senate., University Graduate Committee.

Faculty Senate Records

Meeting minutes from the University Graduate Committee from December 17, 2025.

Enhancing Aerosol Scattering Measurements: Performance Evaluation And Quality Assurance Of Airphoton Integrating Nephelometers In The Surface Particulate Matter Network, Kamlendra Singh Pathak

McKelvey School of Engineering Graduate Student Theses & Dissertations

Integrating nephelometers are key instruments for quantifying aerosol light scattering, a fundamental parameter governing the direct radiative effect of aerosols on climate and visibility, and for interpreting satellite observations of aerosol optical depth. The AirPhoton integrating nephelometer quantifies aerosol light scattering by measuring total scattering from the sample air and subtracting a clean-air reference that represents Rayleigh scattering, instrument wall scattering, and detector background noise. Measurement accuracy depends on rigorous calibration and regular performance evaluation to account for instrumental drift and environmental influences. This study presents a field performance evaluation of the AirPhoton integrating nephelometer within the global Surface Particulate …

Assessing Smooth Muscle Cell Death In Elastase-Treated Mouse Aortas, Bebel B. Trani

Mechanical Engineering and Materials Science Independent Study

No abstract provided.

Towards Science-Based Quantitative Conservation Management Plan Add-Ons For All Alaskan Squirrel Species: Current And Future Distributions, Conservation Management, Contaminant Exposure, And Their Role In Alaska Native Communities, Moriz Steiner

Biological Sciences

Squirrels are widespread in Alaska, yet a science-based conservation management plan (CMP) is absent at the state level. Squirrels are killed year-round with no bag limits, while population metrics remain unknown and conservation statuses disputed. This thesis proposes modern tools and approaches as addons for long-term, sustainable, holistic CMPs for all Alaskan squirrel species in a changing climate. Chapter 1 provides an overview of squirrels' current roles and uses in Alaska alongside existing management practices and regulations. Chapters 2 and 3 conduct thorough conservation assessments by analyzing and predicting current and future distributions of squirrel species across Alaska and a …

40 Priority Questions To Advance Understanding Of The Risks And Opportunities Of Uk Marine Heatwaves, Zoe Jacobs, Kathryn E. Smith, Jules B. Kajtar, Dan A. Smale, Pippa J. Moore, Fabrice Stephenson, Michael T. Burrows, Caroline Rowland, Richard Renshaw, Sophy Oliver, Martyn Jakins-Pollard, Freya Ivy Palmer, Alice Kloker, Craig Baker-Austin, Bryony Townhill, Sian Rees, Sarah Coulthard, Ekaterina Popova

School of Biological and Marine Sciences

Marine heatwaves (MHWs) are periods of anomalously warm sea temperatures that are becoming increasingly recognised as ocean stressors. Globally, MHWs have impacted marine ecosystems, with significant socioeconomic implications for coastal communities and industries. The unprecedented MHW that occurred in the waters surrounding the UK and Ireland in summer 2023 highlighted a crucial gap in our understanding of the region-specific characteristics of MHWs and their impacts on marine ecosystems, the services they underpin, the blue economy and society. Using diverse expert opinion, we propose 40 priority questions for interdisciplinary research in the UK that must urgently be addressed to prepare for …

Co-Production Of A Mobile Application For Parents Of Acutely Ill Children Under Five: ‘Ipoorly Child Symptom Checker, Sarah Neill, Amy Rathbone, John Downey, Monica Lakhanpaul, Matt Carey

School of Nursing and Midwifery

Acutely ill children under five years of age are frequent and increasing users of urgent and emergency care services despite there being no increase in acuity of presenting illnesses. This raises concerns about parents’ level of knowledge and confidence in assessing the severity of symptoms of acute illness, despite the abundance of digital information available. MethodBuilding on prior work to co-develop the content for a mobile app for parents of acutely ill children, we co-designed the iPoorly child symptom checker app using an experience based co-design methodology with seven parent and seven health professional patient and public involvement representatives. The …

Unmasking Oral Health Stigma: A Qualitative Scoping Review, J Doughty, J Booth, M Smith, K Saini, M Paisi, A Rodriguez, A Levine, C Bedos, V Muirhead, C Martins De Barros, C Freeborn

Peninsula Dental School

INTRODUCTION: Health-related stigma can limit access to care, impair adherence to treatment, and negatively impact mental health and quality-of-life. Oral health stigma, defined as stigma arising from oral conditions that diverge from sociocultural norms, operates through labelling, stereotyping, othering, and exclusion. Oral health stigma can lead to shame, diminished self-confidence, and avoidance of dental care, creating a self-perpetuating cycle of poor oral health and reinforcing internalised and anticipated stigma. While previous research has explored the social implications of oral appearance, little is known about the broader concept of oral health stigma or strategies to mitigate it.

METHODS: This scoping review …

Incidence Of Bacterial Chondronecrosis With Osteomyelitis Lameness In Commercial Duck Flocks In Mojokerto, Indonesia, Andi Asnayanti, Siti Azizah, Anif Mukaromah Wati, Ahmad Ridwan, Ahmad Arman Dahlan, Dinda Rosalita, Anh Dang Trieu Do, Adnan Alrubaye

Poultry Science Faculty Publications and Presentations

Bacterial Chondronecrosis with Osteomyelitis (BCO) lameness is an infection of opportunistic bacteria in the structural skeletal bones impacting multiple animal species, particularly poultry species. BCO lameness results in significant financial losses to industrial poultry production and increases the risk of foodborne illnesses, posing a major threat to consumers' food safety. As BCO lameness is an inherent risk of fast body weight gain in poultry species, especially broiler chickens, abundant studies have been conducted in broilers and turkeys. Nevertheless, BCO lameness incidence in ducks remains elusive. Thus, this is the first survey investigating the prevalence of BCO lameness cases in ducks. …

National Football League (Nfl) "Dynamic Kickoff" Rule Change: A Comparative Analysis Of Concussion And Musculoskeletal Injury Incidence, Troy Puga, Tanner Haechten, Coleman Cush, Mckenna Box, Hans Drawbert, John Riehl

Student Publications

Background: Kickoffs in the National Football League (NFL) are historically one of the most dangerous plays during an NFL game, with high levels of injuries. In 2024, the NFL introduced new rules aimed at reducing injuries during kickoffs, enhancing player safety, and increasing the frequency of kick returns.

Purpose: To evaluate whether the NFL kickoff rule changes in 2024 had any effect on the incidence of injuries, particularly with a focus on concussions.

Study design: Descriptive epidemiology study.

Methods: Injuries on kickoffs were identified for the 2022, 2023, and 2024 NFL seasons using the transcribed game book for each game …

Programmable Acoustofluidic Engineering For Creating Gradient Biomaterials, Jujing Lu, Ye He, Jianping Xia, Mingyuan Liu, Joseph Rich, Ke Jin, Ruoyu Zhong, Kaichun Yang, Jiao Qian, Ying Chen, Ke Li, Zhiteng Ma, Tony Jun Huang

Faculty Publications

Gradient biomaterials that exhibit spatially varying physical, chemical, or biological properties can be used in various applications such as tissue engineering, organoid development, mechanobiology, and spatially controlled drug delivery. However, current fabrication methods often suffer from limited gradient precision, restricted material compatibility, and poor reproducibility. Here, we introduced gradient regulation via acoustofluidic dynamic engineering (GRADE), a programmable system to generate high-fidelity gradient biomaterials across different material systems. By incorporating focused interdigital transducers with the pulsed surface acoustic wave actuation, GRADE can achieve tunable and directional acoustic streaming (0 to 22 millimeters per second), which allows accurate regulation of the gradient …

Unraveling The Drivers Of Inequality In Maternal Healthcare Utilization In Indonesia: A Decomposition Analysis, Wji Wahyuningsih, Kemal N. Siregar, Syifa Nurhakiki

Jurnal Ekonomi Kesehatan Indonesia

This study assessed socioeconomic inequalities in maternal healthcare utilization in Indonesia and identifies key factors driving these inequalities. We used data from 2013 and 2023 Indonesian Health Surveys, comprised of a total unweighted sample of 15,638 and 9,923 women aged 15-49 in the 2013 and 2023, respectively. Concentration index (CI) measured wealth-based inequality, and decomposition analysis identified primary drivers of inequalities in maternal healthcare access. Overall maternal healthcare service utilization has increased, but significant inequalities persist. Antenatal care showed minimal improvement, with the CI rising from 0.059 to 0.079, indicating a persistent higher socioeconomic distribution. Facility-based deliveries improved, with the …

Invisible No More: National Solutions For Protecting Unaccompanied And Separated Migrant Children In Egypt, Enas Abdel Azim, Noran Khorsheed, Raghda Bahy Elessawy, Tharwat Abaza

Papers, Posters, and Presentations

Egypt has a strategic geographical position as a significant destination and transit country for unaccompanied and separated migrant children (UASC). With a substantial and rapidly increasing migrant population, exacerbated by recent regional influxes, the country’s public infrastructure and resources are experiencing considerable strain. While Egypt has demonstrated its commitment to child rights through the ratification of key international instruments like the Convention on the Rights of the Child (CRC) and the African Charter on the Rights and Welfare of the Child (ACRWC), UASC in the country nonetheless face complex protection challenges, including legal visibility concerns, risk for exploitation, and barriers …

Heavenly Or Soul Sanctuary? Some Holistic Theological And Ethical Implications, Davide Sciarabba

Ellen White Issues Symposium

No abstract provided.

Beyond Gun Control: How March For Our Lives Frames Gun Violence Prevention As Positive Peace, Ashley E. Nickels, Amanda D. Clark

Peace and Conflict Studies

March for Our Lives (MFOL) is a youth-led social movement that has redefined the framing of gun violence prevention, expanding it beyond policy-focused gun control efforts to a broader vision of positive peace. Rather than positioning gun violence solely as a matter of firearm regulation, MFOL constructs it as a structural justice issue, linking it to systemic inequities such as racial oppression, economic inequality, and political disenfranchisement. This study examines how MFOL’s movement framing reshapes understandings of gun violence prevention by emphasizing community transformation, intersectional justice, and collective safety. Drawing on framing theory, we analyze how MFOL presents gun violence …

Women As Strategic Partners In Peacebuilding And Social Cohesion In Rural- Based Mining Areas: The Case Of Wards 1 And 2 Insiza District, Matebeleland South In Zimbabwe, Dumisani Maqeda Ngwenya, Sikhathele Mathambo

Peace and Conflict Studies

This article discusses the efficacy of the “women as strategic partners in peacebuilding” program, under the broader overarching Building Resilience, Inclusiveness, Social Cohesion and Healing Project, which is a response to the gendered conflicts and violence caused by the presence of artisanal mining in two wards of Insiza District, Matebeleland South in Zimbabwe. The intervention was premised on strengthening women’s capacity to create safe platforms for inclusive dialogue, consensus-building and decision making to address conflicts and creating a conducive environment for collaboration and trust, to enhance social cohesion and build a more peaceful society. Peace committees (PCs) established by Emthonjeni …

"Net Worth" Song Lyrics, Undated, Bill Gessner

Bill Gessner Song Lyrics and Poems

Song lyrics for "Net Worth" by Bill Gessner. Four double-sided pages include handwritten and typed lyrics, notes, and revisions. No date is indicated on the lyric sheets. Gessner writes about an encounter he had at the bank when trying to get a loan.

Healing Through History, Nancy Baker Jones

Journal of Texas History

This is the written transcription of the author’s closing plenary address to the inaugural conference of the Alliance for Texas History, May 17, 2025. Its purpose is to put into both broad and personal historical contexts the events of 2023 and 2024 that led to the founding of the Alliance for Texas History. It concludes that, despite the difficulties of those events for her and for many other historians of Texas, history offers a potentially healing context for moving forward.

James White’S First Stroke And Rising Tension Between Adventist Leaders, Kevin M. Burton

Ellen White Issues Symposium

No abstract provided.

The Chinese Reception Of Ellen G. White, Christie Chui-Shan Chow

Ellen White Issues Symposium

No abstract provided.

Dens Evaginatus: Odontogenesis Anomaly Case Reports, Robert Warren Dds, Elizabeth Berry Dds

Virginia Dental Journal

No abstract provided.

Critical Assessments Of The Bible And The Writings Of Ellen G. White, Alberto R. Timm

Ellen White Issues Symposium

No abstract provided.

Demonization And Protection From Evil Spirits In The Writings Of Ellen G. White With Missiological Implications, Bruce L. Bauer

Ellen White Issues Symposium

No abstract provided.

Marketcrafters: The 100-Year Struggle To Shape The American Economy, Jay Nathan

Journal of Global Awareness

No abstract provided.

A Content Analysis Of Spanish Language Curriculum In Texas, Sarah Moore, Jessica Sanchez, Sarah Herrera

Journal of Global Awareness

The shortage of Spanish-speaking social workers is significant in the United States, especially in border states such as Texas. Experts are calling for Spanish language training in social work education. However, it is unclear whether social work programs are incorporating Spanish into their curriculum at a pace needed to keep up with demand. Using conceptual content analysis, this article examines the frequency of Spanish language courses relevant to social work education across Texas.

Trustworthy Ai: Prohibited Practices, Ethical Principles, And The Identification Of Problems, Anna Karmańska

Journal of Global Awareness

The following considerations arise from the study of texts of documents of a legal nature and from the author’s judgments. They do not present the results of the author’s own empirical research; however, they constitute a factual study that is important for their undertaking in the next step. Having given concern but also hopes for AI, the author focuses her attention on issues that, not only in her opinion, have a strong bearing on the preservation of humanity in a digital environment and at the same time with technocratic features. These issues (prohibited practices, high-risk systems, and ethics) related to …

Music And Sustainable Development Goals: Telling The Story, Mark Reimer

Journal of Global Awareness

Now, 10 years after the United Nations adopted its 17 Sustainable Development Goals, the music profession continues to work toward being a responsible partner in the health and preservation of the planet and its inhabitants. By transcending social barriers, music promotes cultural awareness and mutual understanding, encourages creativity, and enhances emotional well-being, outcomes vital to the global goals of health, freedom, peace, education, equality, prosperity, and environmental sustainability. The article includes various examples of how music performers, educators, composers, and scholars are creating or adopting new practices that are mindful of reducing the carbon footprint, yet financially feasible in their …

Economic Development And Its Transformation In Happiness: A Perspective Of Sustainable Development Goals Of Nepal, Dhruba Bhattarai, Bishnu Bhattarai

Journal of Global Awareness

The present paper attempts to explore the relationship between GDP Per Capita Income based economic measurements of people’s well-being in the form of happiness. The overall development of a country’s economy must be translated into people’s well-being and happiness, which the study focuses on using the relevant data. The secondary data of the Human Development Index, Gross Domestic Product, Per Capita Income, and Happiness Index for the last 20 years have been collected and analyzed. To assess the psychological aspects of the happiness concept, the relevant happiness indicators such as life expectancy, educational attainment, and index of economic freedom have …

Notes From The Editor, Jay Nathan

Journal of Global Awareness

No abstract provided.