Digital Commons Network^™

Socio-Spatial Patterns Of Suicide Mortality In The United States, Kushagra Tiwari, M. Amin Rahimian, Marie-Laure Charpignon, Philippe J. Giabbanelli, Praveen Kumar

VMASC Publications

Suicides cause more than 49,000 deaths per year in the United States, including 55% associated with the use of a firearm. Across states and counties in the US, suicide mortality exhibits substantial geographical and sociodemographic heterogeneity. However, the role of large-scale social networks in shaping this variation remains underexplored. To assess how both the risk of suicide mortality and the effect of firearm restriction policies propagate through inter-county social ties, we integrate data on county-level suicide mortality (2010–2022) and the Facebook Social Connectedness Index (SCI), a continuous measure of the strength of social ties between counties used to derive weighted …

Synergistic Sensitization Of Pancreatic Cancer Cells By Nanosecond Pulsed Electric Fields And Cold Atmospheric Plasma Via Amplifying Ros And Apoptotic Signaling, Zobia Minhas, Edwin A. Oshin, Lifang Yang, Chunqi Jiang, Siqi Guo

Bioelectrics Publications

Pancreatic cancer remains a highly lethal malignancy, with standard therapies offering limited benefits in advanced stages; thus, novel strategies that exploit specific cancer cell vulnerabilities are urgently needed. Building on our previous findings that nanosecond pulsed electric fields (nsPEF) combined with cold atmospheric plasma (CAP) produce enhanced cytotoxicity, this study investigates the molecular mechanisms underlying this synergy. Pan02 pancreatic cancer cells were subjected to nsPEF, CAP, or a combination of both. We assessed cell viability, reactive oxygen species (ROS) production, and mitochondrial integrity using metabolic assays, flow cytometry, and fluorescence microscopy. Apoptotic markers were evaluated via Western blotting and caspase …

Targeting Ptp4a3 And Kvx-053 Mitigates Alcohol-Amplified Sars-Cov-2 Spike Protein-Induced Acute Lung Injury, Pavel A. Solopov, Ruben Manuel Luciano Colunga Biancatelli, Elizabeth R. Sharlow, John S. Lazo, John D. Catavas

Bioelectrics Publications

Introduction: Chronic alcohol exposure is associated with increased vulnerability to acute respiratory distress syndrome (ARDS), and emerging evidence suggests that this susceptibility extends to the severe respiratory manifestations of COVID- 19. The SARS-CoV-2 Spike Protein S1 subunit (S1SP) can independently trigger robust inflammatory and vascular injury responses in the lung, and our prior work demonstrated that chronic alcohol consumption markedly intensifies these effects in mice. PTP4A3 phosphatase is a key regulator of inflammation and endothelial barrier function. In this study, we investigated whether the PTP4A3 inhibitor KVX-053 can counteract alcohol-enhanced S1SP-induced lung injury in K18-hACE2 mice.

Methods: Animals were maintained …

Nanosecond Electric Pulses As A Novel In Situ Vaccination Strategy For Cancer Treatment: Mechanisms, Challenges And Prospects, Siqi Guo

Bioelectrics Publications

Nanosecond electric pulses (nsEPs) are an emerging pulsed-power technology with unique bioelectric characteristics distinct from conventional long-pulse electroporation. As a tunable physical modality, nsEPs can modulate intracellular structures, membrane dynamics, and signaling pathways. Increasing evidence supports nsEPs as a promising non-thermal tumor ablation approach due to their high spatial precision, preservation of critical tissue structures, and minimal adverse effects. One of the most significant discoveries associated with nsEP tumor ablation is the induction of potent systemic antitumor immunity, particularly in situ vaccination (ISV) effects and, in some cases, abscopal effects against distant untreated tumors. Substantial evidence demonstrates that nsEPs can …

Hsp90 Inhibitor, At13387 Mitigates Chronic Lung Injury In Pre-Pubertal Mice: A Therapeutic Axis In Bronchopulmonary Dysplasia, Pavel A. Solopov, Christiana Dimitropoulou, John D. Catravas, Ruben M. L. Colunga Biancatelli

Bioelectrics Publications

Exposure to hydrochloric acid (HCl) can provoke severe chronic pulmonary injury. Children are particularly vulnerable due to their smaller airways, higher respiratory rate, and stronger inflammatory response; yet no countermeasures exist for HCl-induced chronic lung injury in the pediatric population. We have previously demonstrated the involvement of HSP90 during HCl-induced lung injury in pre-pubertal (p24) mice, who develop stronger persistent inflammation with higher NLRP3 inflammasome activation, but less pulmonary fibrosis compared to adults. Here, we tested the hypothesis that post-treatment with the second-generation HSP90 inhibitor AT13387 (Onalespib), administered subcutaneously beginning 24 h after HCl instillation, would prevent HCl-induced chronic lung …

The Sec And Climate Litigation, Lisa Benjamin

Lewis & Clark Law Review

The controversy surrounding the SEC’s climate-related financial disclosure rule continues. This Essay updates my previous work on this issue, where I identified two opportunities and two obstacles to the SEC promulgating final rules on climate-related financial risk disclosures. The two opportunities were a shifting political landscape under the then-Biden Administration (which took a whole-of-government approach to addressing the climate crisis) and rising investor concern over the risks that climate change posed to their investments. The two obstacles I identified were business resistance to disclosure rules, and rising judicial hostility to the SEC. Today, the political landscape has shifted dramatically and …

A Strategic Approach To “E”Sg Reporting, Taylor Nchako

Lewis & Clark Law Review

Environmental, Social, and Governance (ESG) factors have emerged as an important investment tool for the financial sector to address climate change. While the federal government has abandoned ESG disclosure, U.S. firms still face reporting obligations domestically and abroad. States across the country have proposed or passed two types of disclosure laws: greenhouse gas emissions disclosure and climate risk disclosure. These state-level efforts mirror actions in the European Union, Canada, and other jurisdictions in which U.S. firms operate.

As ESG disclosure standards are adopted in jurisdictions around the world, these standards are undergoing various advancements, reductions, and contestations. These shifts in …

Taking Off The “Blindfold”: Exploring Montana’S Public Trust Doctrine And The Right To A Clean And Healthful Environment After Held V. Montana, Lizzy Gazeley

Lewis & Clark Law Review

As global average temperatures continue to rise, the threat of climate change looms closer. To evade climate catastrophe, greenhouse gas emissions will need to be substantially reduced. Despite climate change’s imminent risks, in the United States, both the federal government and states remain resistant to transitioning away from fossil fuel energy sources. To combat this government inaction, some litigants have turned to an ancient doctrine. The public trust doctrine provides that sovereigns must protect natural resources from substantial impairment to ensure the public’s right to use those resources.

In Held v. Montana, youth plaintiffs alleged that the State of Montana …

A Scope For Survival: Creating A Path For The Pregnant Workers Fairness Act Under A Conservative Administration And Supreme Court Bench, Emily Easton

Lewis & Clark Law Review

The Pregnant Workers Fairness Act (PWFA) requires employers to provide reasonable accommodations for known limitations related to pregnancy, childbirth, or related medical conditions, representing a bipartisan congressional effort to fill the gaps in workplace protections afforded to pregnant workers. However, the Equal Employment Opportunity Commission’s (EEOC) final rules interpreting the PWFA have generated significant legal and political controversy—especially around the broad interpretation of the definition of related medical conditions to include lactation, “elective” abortions, menstruation, infertility, and contraception.

Given the current political and legal climate presented by a conservative federal administration and Supreme Court bench, this Note proposes a pragmatic …

Anything For Views Parenting, Bahar Tarighi

Lewis & Clark Law Review

Children who appear in monetized family vlogs are the product. Without them, the content would not exist, and the revenue would not follow. Yet unlike child actors in traditional entertainment, these children receive no guaranteed wages, no mandated trust accounts, and no right to control the digital record created in their name. This gap is a product of a legal framework that has simply not kept pace: the Fair Labor Standards Act, enacted in 1938, expressly exempted child performers from its protections, and neither Congress nor the majority of states have updated their child labor frameworks to account for the …

Regulated Victimization: The Rise Of Human Trafficking Within The Oregon Massage Industry, Hannah Beaulieu

Lewis & Clark Law Review

Illicit massage businesses are massage spas that appear to operate as legitimate businesses but facilitate commercial sex acts behind closed doors. Recent law enforcement investigations in Oregon have revealed that some illicit massage businesses have facilitated the human trafficking of multiple victims. The illicit massage industry has steadily grown across the country but has especially boomed in recent years in Oregon. This Note investigates how the illicit massage industry has evolved to be so prevalent in our communities and what factors have contributed to the growth. It goes on to recommend ways to protect victims, to prevent further harm, and …

Quo Warranto In The Aftermath Of Loper Bright, Dennis Hall

Lewis & Clark Law Review

In 2024, the Supreme Court did away with Chevron deference in Loper Bright Enterprises v. Raimondo. One previously undiscussed consequence of this decision is how it opens the door to a broader use of quo warranto corporate charter revocation. Quo warranto is a legal remedy held by the states that has fallen into relative obscurity, but it has the power to regulate large corporations that have strayed from the bounds of acceptable activity. This Comment examines the history of corporations and corporate oversight regulation in the United States, as well as the history of quo warranto as a remedy. Additionally, …

Foreword, Mckenzie Porter

University of Colorado Law Review

No abstract provided.

"Women’S Language" In Supreme Court Oral Arguments, Carolina Nunez, Lucy Williams, David Wingate, Aerin Christensen, Anna Mae Walker

University of Colorado Law Review

No abstract provided.

Assuming Accent: Recognizing The Intersection Of Race And National Origin In Title Vii Discrimination, Eun Hee Han

University of Colorado Law Review

No abstract provided.

Understanding Adaptation, Resilience, And Thriving Among Vietnamese Catholic Missionary Sisters In The United States Through The Lens Of Traditions, Transitions, And Leadership, Huyen T. Nguyen

Educational and Organizational Learning and Leadership Dissertations

While the presence of international Catholic Sisters serving in the United States has grown (Johnson et al., 2019), the lived experiences of Vietnamese Catholic Missionary Sisters remain largely absent from the scholarly literature. Addressing this gap, this qualitative study examined adaptation, resilience, and thriving among the Sisters serving in the United States by centering their voices through in-depth narratives. Their experiences were interpreted through Social Identity Theory, Servant Leadership, and Transformational Leadership Theory within the context of Vietnamese Catholicism and the charism of the Lovers of the Holy Cross. Data were collected through semi-structured interviews with 10 Sisters ministering in …

Never Cool Enough: Legal And Policy Challenges To Keeping Data Centers And Communities Empowered In A Warming World, Cristina M. Banahan, Diana B. Wilkinson

Lewis & Clark Law Review

In a rapidly evolving world, artificial intelligence (AI) and cryptocurrency are two technologies at the forefront of the future. Although these developments promise many potential societal benefits and revenue, they come with a price. The data processing required to operate these new technologies demands a large amount of energy, using water to cool the systems and enable them to run without overheating. With such high water and energy demands, the benefits from these technological advancements come at a steep environmental cost. Despite the negative environmental impacts of these data centers, the Trump Administration continues to roll back environmental protections. The …

Changing Student Perspectives On Alcohol, Smoking & Vaping Through The Use Of Tetrahymena, Courtney Hausner, Douglas L. Chalker, Alexandra Forgerson, Carol E. Colaninno, Alison Brockhouse, Rachel Ruggirello

Institute for School Partnership: Research & Publications

We describe the redesign and classroom testing of an Advancing Secondary Science Education through Tetrahymena (ASSET) module addressing adolescent alcohol, smoking, and vaping. Using the 5E instructional model, the module has students investigate how alcohol, cigarette smoke extract, and vape extract affect the ciliated protozoan Tetrahymena, an accessible proxy for effects on ciliated human respiratory cells. Students analyze public health data, conduct guided and self-designed investigations, and create outreach posters communicating evidence-based risks to peers. We report on observations from two classroom implementations, describing gains in students' ability to articulate toxicology concepts, connect cellular findings to whole-body health, and express …

“My Voice Is Trauma, My Voice Is Healing:” A Feminist, Trauma-Informed Embodied Study On The Impact Of Gender-Based Violence In Classical Music Communities, Sarah Pearson

Theses and Dissertations (Comprehensive)

This Social Work doctoral dissertation explores the impact of gender-based violence (GBV) in classical music communities on survivor-artists. This is an intersectional feminist, trauma-informed, embodied study that draws on these three theoretical concepts to conceive of classical music as an institution of both colonial patriarchal power and a site of spirituality and meaning-making. The issue of systemic GBV in the performing arts has been a focus of headline news and sensational celebrity stories in the last decade following the MeToo hashtag and is slowly gaining some attention in academic research.

For this qualitative study, the sample consisted of 14 participants …

A Constructivist Grounded Study: At The Intersection Of Religion And Intimate Partner Violence In The Context Of An Ultra-Orthodox Jewish Community, Lauren Kalvari

Theses and Dissertations (Comprehensive)

This constructivist grounded theory study, informed by a critical intersectional lens and guided by symbolic interactionist theory, explored how Ultra-Orthodox Jewish women experience and navigate intimate partner violence (IPV) within their religious and community contexts. Ten participants, recruited through purposive and theoretical sampling, were separated or divorced from abusive partners for at least eight months and had engaged in psychotherapy, allowing for retrospective meaning-making. Each participant completed one to three in-depth interviews on IPV, community responses, spiritual conflict, and recovery. Data collection and analysis were conducted concurrently using Charmaz’s iterative constructivist grounded theory approach, which included initial, focused, and theoretical …

Picturing Your Goals: Examining Imagery Perspective And Self-Concordance In Goal Motivation, Cana J. Reuber

Theses and Dissertations (Comprehensive)

Mental imagery is often used as a strategy to increase motivation and support goal pursuit, but it remains unclear when different forms of imagery are most effective. Prior work suggests that adopting a third-person imagery perspective may enhance goal striving by promoting more abstract, identity-relevant processing. In line with this work, we predicted that third-person imagery would be most beneficial for self-concordant goals. The present research tested this prediction across three studies. In Study 1 (N = 273), participants identified a personal goal, visualized themselves pursuing and attaining it from either a first- or third-person perspective, and reported their …

The Power Of Letting Go: The Role Of Goal Adjustment Capacities Across Future And Daily Perspectives Of Chronic Illness, Alexandra Dagher, Meaghan Barlow

Theses and Dissertations (Comprehensive)

Goal adjustment capacities are self-regulatory processes that protect psychological well-being by allowing individuals to disengage from unattainable goals and reengage in new attainable ones. Although research has shown that these capacities are beneficial in the context of chronic illness, little is known about how their effectiveness may differ across various aspects of the chronic illness experience. The present research consisted of two distinct yet complementary studies examining the role of goal adjustment capacities in two chronic illness contexts. Study 1 (N = 149) prompted participants to imagine the future progression of a chronic illness, whereas Study 2 (N …

Formulation Modification Of Silver Diamine Fluoride To Improve Clinical Handling And Dentin Tubule Occlusion, Liangyu Chang, Yutzu Wu, Powen Lu, Iwen Chen, Weifang Lee, Chunche Lin, Renjei Chung, Poonam Negi, Naichia Teng, Jenchang Yang

Journal of Dental Sciences

Background/purpose: Silver diamine fluoride (SDF) is clinically effective for treating dentinal hypersensitivity and arresting caries, but its poor clinical handling due to low viscosity remain concerns. This study aimed to enhance the rheological properties of SDF by incorporating sodium carboxymethylcellulose (CMC) to improve its clinical manageability. Materials and methods: A 39.34 wt% SDF solution (TMU-SDF) was prepared via wet processing. Its matrix metalloproteinase (MMP) inhibition was evaluated using a fluorogenic MMP-1 assay, and antibacterial activity was tested via an inhibition zone assay. Biocompatibility was assessed using a modified cytotoxicity-agar diffusion test and a skin sensitization test. Rheological properties, including flow …

Influence Of Serum Vitamin D Levels On Marginal Bone Loss Around Unsplinted Mandibular Implant Overdentures: A Retrospective Study, Rahma El Hussany Mohammed El Desouky, Fatma Ahmad El-Waseef

Mansoura Journal of Dentistry

Objective: To investigate the impact of serum vitamin D levels on marginal bone loss (MBL) in patients restored with unsplinted-mandibular-implant overdentures using LOCATOR attachments. Materials and Methods: Thirty participants rehabilitated with three-implant-mandibular overdentures were included. Based on serum vitamin D at the time of prosthetic loading, participants were categorized into two equal groups: a test group with deficient vitamin D (< 20 ng/mL) and a control group with sufficient levels (≥30 ng/mL). Patients with borderline levels (21–29 ng/mL) were excluded. Peri-implant vertical (VBL) and horizontal bone loss (HBL) were measured at baseline (T0), 6 months (T6), and 12 months (T12). Results: The vitamin D-deficient group exhibited significantly elevated VBL and HBLover the sufficient group at all-time points (P

Cephalometric Norms And Sexual Dimorphism In The Tanzanian Population: A Comparative Study With Caucasian And West African Norms, Ali K. Hamad, Ferdinand M. Machibya, Matilda M. Mlangwa, David N. Ngassapa

Mansoura Journal of Dentistry

Objective: This study aimed to establish cephalometric norms for the Tanzanian population, assess sexual dimorphism in cephalometric measurements, and compare these findings with established Caucasian and West African norms to enhance orthodontic diagnosis and treatment planning. Materials and Methods: A crosssectional study was conducted on 309 subjects (142 males, 167 females) at Muhimbili University Dental Clinic. Cephalometric radiographs were digitally traced using Quick Ceph Studio. Reliability was assessed using the inter-class correlation coefficient. The Kolmogorov-Smirnov test checked normality, while one-sample t-tests and Student’s ttests (p < 0.05) were used for comparisons. Data were analyzed with RStudio. Results: Tanzanians showed significantly smaller craniofacial measurements than Caucasians. Males had larger skeletal dimensions than females. Compared to West Africans, Tanzanians had generally higher values, with a few exceptions. Conclusion: Tanzanians display distinct craniofacial characteristics, differing from both Caucasians and West Africans. These findings support the need for population-specific cephalometric norms to guide accurate orthodontic diagnosis and treatment.

The Mitosis-Specific Antibody Anti-Phosphohistone-H3 (Phh3) And Its Relation To The Histopathological And Biological Characteristics Of Ameloblastoma And Ameloblastic Carcinoma, Husam Asadiq S. Alrumayh, Samar Soliman, Khadiga M. Ali, Hoda M Ismail, Azza Abbas El-Sissi

Mansoura Journal of Dentistry

Aim This study aimed to assess the immunohistochemical (IHC) expression of phosphohistone H3 (PHH3) in multicystic ameloblastoma (AB), unicystic AB and ameloblastic carcinoma (AC) and to investigate the mitotic activity difference between these lesions. Material and Methods This study was carried out on 30 cases, classified into three groups Group I 13 cases of multicystic AB. Group II 7 cases of unicystic AB Group III 10 cases of AC. These cases were selected from the Oral Pathology Department, Mansoura University and Cairo University archives from 2023 to 2024. Immunohistochemistry for PHH3 was done and the immunoreactivity was evaluated by the …

Evaluation Of Soft Tissue Response Of Two Different Provisional Prothesis Used For Immediate Load Full Arch Implant Prosthesis. Randomized Control Clinical Trial, Mubeen Jaafar Imran, Mohammed Hussein Raafat Abd Elfatah, Sally Elsayed Abdelsameaa, Moustafa Abdou Moustafa Elsyad

Mansoura Journal of Dentistry

Purpose: The study seeks to evaluate the gingival index (GI), probing depth (PD), plaque index (PI) for bar reinforced 3D printed provisional full arch and Milled PMMA (polymethyl methacrylate) provisional full arch prostheses. Materials and methods: This study involves immediate implant placement in completely edentulous mandibles using computer-guided surgery. Patients are selected based on CBCT evaluation, ensuring bone density between D1 and D3. A removable complete denture was first fabricated to restore the occlusal plane. A dual scan technique was used with radiopaque markers for digital planning. Virtual prosthesis planning was performed using Exocad software. A stackable surgical guide was …

Extended Platelet Rich Fibrin In Mandibular Alveolar Ridge Splitting With Simultaneous Implant Placement, Faisal Hammad Nuhater Alshammary, Heba Abo-Elfetooh Elsheikh, Walid Abd El-Ghafar Al-Zordk, Noha Ahmed Mansour

Mansoura Journal of Dentistry

Purpose: To evaluate, both clinically and radiographically, the use of extended platelet-rich fibrin versus a pericardium membrane in mandibular ridge splitting accompanied by immediate implant placement.

Materials and Methods: A total of sixteen implants were placed in eight patients with horizontally atrophic posterior mandibular ridges measuring 3–6 mm in width were randomly assigned to two groups with equal numbers. Both groups underwent ridge splitting with simultaneous implant insertion. In Group I, the intercortical defect was grafted with bone allograft and covered using a pericardium membrane, while Group II received extended platelet-rich fibrin (e-PRF) membrane instead. Clinical assessment focused on assessment …

Smallholder Farmers' Willingness To Pay For The Farmbetter Mobile App-Based Agricultural Extension: Evidence From A Bdm Experiment In Tanzania And Burkina Faso, Cool Dady Mangole, Kelvin Mulungu, Christian Kamala Kaghoma, Maurice Tschopp, Menale Kassie

All Peer-Reviewed Publications

Financial contributions from farmers are increasingly acknowledged as a sustainable mechanism for funding extension services. However, the literature on willingness to pay (WTP) for digital agricultural extension is limited. Conducting a thorough assessment of WTP for digital extension is critical for designing effective pricing policies and ensuring financial sustainability. This study examines the WTP for a novel digital extension platform named farmbetter, leveraging primary data collected in Tanzania and Burkina Faso. The Becker-DeGroot-Marschak (BDM) experiment was used to elicit the amount farmers are willing to pay. We applied the Lasso machine learning to predict the relevant drivers of WTP and …

Editorial: Sustainable Management Of Tuta Absoluta, Ahmad A. Omar, Inusa Jacob Ajene, Hafiz Muhammad Usman Aslam, Fathiya Mbarak Khamis

All Peer-Reviewed Publications

The tomato leafminer, Tuta absoluta (Meyrick), remains one of the most devastating global threats to tomato production. Its rapid invasion across continents, exceptional reproductive potential, cryptic foliar-mining behavior, and accelerated evolution of insecticide resistance have significantly complicated management efforts. The persistent failure of conventional chemical strategies underscores an urgent need for integrated solutions that combine molecular innovation, ecological engineering, and rigorous resistance monitoring. This editorial synthesizes key insights from recent contributions by Ullah et al., Bavithra et al., and Adams et al., which collectively outline a transformative, multi-dimensional framework for sustainable T. absoluta suppression.