Digital Commons Network^™

Identification Of Neural Crest And Melanoma Cancer Cell Invasion And Migration Genes Using High-Throughput Screening And Deep Attention Networks., J C Kasemeier-Kulesa, S Martina Perez, R E Baker, Paul M. Kulesa

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Cell migration and invasion are well-coordinated in development and disease but remain poorly understood. We previously showed that the neural crest (NC) cell migratory wavefront shares a 45-gene panel with other cell invasion phenomena. To rapidly and systematically identify critical genes, we performed a high-throughput siRNA screen and statistical and deep learning analyses to determine changes in NC- versus non-NC-derived human cell line behaviors.

RESULTS: We find 14 out of 45 genes significantly reduced c8161 melanoma cell migration; four of the 14 genes altered leader cell motility (BMP4, ITGB1, KCNE3, and RASGRP1). Deep learning identified marked disruptions in cell-neighbor …

Safety And Effectiveness Of Emicizumab In People With Haemophilia A Enrolled In The Athn 7 Haemophilia Natural History Study., Tyler W. Buckner, Shannon L. Carpenter, Nabil Daoud, Christine L. Kempton, Lucy Lee, Lynn Malec, Thomas W. Mclean, Paul Morton, Carrie O'Neill, Janice M. Staber, Michael Wang, Stacy E. Croteau, Michael Recht

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: The Natural History Study of the Safety, Effectiveness, and Practice of Treatment for People with Haemophilia (ATHN 7) monitors use of contemporary haemophilia therapies, including emicizumab, a bispecific antibody substituting for activated factor (F)VIII in people with haemophilia A (HA).

AIM: To report participant characteristics and real-world safety and effectiveness of emicizumab in ATHN 7.

METHODS: ATHN 7 is a prospective observational cohort study conducted across 26 American Thrombosis and Haemostasis Network (ATHN)-affiliated sites. People with HA receiving emicizumab were eligible for inclusion in this analysis. Clinical information was collected quarterly through participant interview and medical record review. Safety …

A 20th Century Historical Perspective On Congenital Syphilis And Lessons For Today., Jane F. Knapp, Robert Schremmer

Manuscripts, Articles, Book Chapters and Other Papers

No abstract provided.

Multisystem Predictors Of Dynamic Gait Stability Across Fall Risk In Older Adults, Ashwini Kulkarni, Neda Moghim, Ross Gore, Soumya Banerjee, Christopher K. Rhea, Brittany Samulski

Rehabilitation Sciences Faculty Publications

Gait stability arises from interactions between physiological, cognitive, and psychological systems, yet these domains are often assessed in isolation. This study examined multisystem predictors of anteroposterior margin of stability during walking (MoSAP) in community-dwelling older adults. Of 340 participants, 143 were retained after data quality screening (105 females; age: 70.8 ± 7.8 years). Participants completed the Physiological Profile Assessment (PPA), cognitive testing using Montreal Cognitive Assessment (MoCA), fear-of-falling evaluations using Modified Falls Efficacy Scale (MFES) and a biomechanical gait assessment during preferred and fast speeds. Participants were stratified into four PPA-based fall-risk groups: low, mild, moderate, and high risk. MoSAP …

Preoperative Patient Sentiment Is Associated With Postoperative Outcomes In Adult Spinal Deformity Surgery, Ross J. Gore, David Mazur-Hart, Mohan K. Sunkara, Aaqib Ali, Qizar Ali, Christopher J. Lynch

Center for Secure and Intelligent Critical Systems (CSICS) Publications

Study Design:

Prospective observational pilot study of adult spinal deformity surgery patients.

Objective:

To determine whether preoperative patient sentiment, quantified using a 21-class valence scale extending the CARP paradigm implemented through an offline Large Language Model, predicts postoperative outcomes.

Summary of Background Data:

Predicting adult spinal deformity surgery outcomes remains challenging with traditional clinical and radiographic parameters alone. Although patient psychological factors and expectations significantly influence postoperative satisfaction and quality of life, systematic approaches to capture these factors are underdeveloped. Offline Large Language Models offer scalable, privacy-preserving psychological risk stratification.

Materials and Methods:

We prospectively enrolled 18 patients undergoing adult …

Cognitive Prosthetic: An Ai-Enabled Multimodal System For Episodic Recall In Knowledge Work, Lawrence Obiuwevwi, Krzystof J. Rechowicz, Vikas Ashok, Sachin Shetty, Sampath Jayarathna

Computer Science Faculty Publications

Modern knowledge workplaces increasingly strain human episodic memory as individuals navigate fragmented attention, overlapping meetings, and multimodal information streams. Existing workplace tools provide partial support through note-taking or analytics but rarely integrate cognitive, physiological, and attentional context into retrievable memory representations. This paper presents the Cognitive Prosthetic Multimodal System (CPMS)—an AI-enabled proof-of-concept designed to support episodic recall in knowledge work through structured episodic capture and natural language retrieval. CPMS synchronizes speech transcripts, physiological signals, and gaze behavior into temporally aligned, JSON-based episodic records processed locally for privacy. Beyond data logging, the system includes a web-based retrieval interface that allows users …

Evaluation Of Mycoplasma Genitalium Positivity And Co-Infection With Chlamydia Trachomatis And/Or Neisseria Gonorrhoeae At Various Care Sites Across The United States, Rebecca Lillis, Rodney Arcenas, Christy M. Boraas, Steven E. Chavoustie, Lashonda Crane, Nicole D'Empaire, Aaron C. Ermel, Glenn Harnett, Federico Hinestrosa, Stacey House, Joseph Miller, Anthony Mills, Ronald Poblete, Stephen Young, Barbara Van Der Pol

School of Medicine Faculty Publications

OBJECTIVES: We evaluated Mycoplasma genitalium (MG) positivity and co-infection with Chlamydia trachomatis (CT) and/or Neisseria gonorrhoeae (NG), based on results from a trial assessing clinical performance of the Cobas® Liat CT/NG/MG point-of-care test. METHODS: A prospective, US, multicenter, noninterventional study assessed MG positivity in prospective urine samples (male) and clinician-collected vaginal swabs (female) from symptomatic/asymptomatic patients aged ≥14 years attending various clinical settings. Participants were designated positive or negative for MG, CT, and NG based on combined results from three US Food and Drug Administration-approved assays and one laboratory-developed test. MG co-infection with CT and/or NG was assessed. RESULTS: Among …

Optimizing Healthy Aging: A Preventative Approach To Support Community-Dwelling Older Adults, Jada Welke

Occupational Therapy Capstones

Introduction: Healthy aging is a complex and multidimensional process influenced by physical, cognitive, psychosocial, environmental, and lifestyle factors across the lifespan. Increasing evidence from researchers suggests that many health care systems continue to rely on reactive models that address decline only after functional limitations emerge. Preventive interventions initiated in midlife have the potential to significantly influence long-term health outcomes, independence, well-being, and quality of life. As a result, there is growing recognition that multidimensional, proactive screening and intervention should begin earlier, before age-related conditions become clinically significant.

Purpose: The purpose of this scholarly project was to address this need through …

From Play To Pressure: Understanding Early Sports Specialization Through An Occupational Lens, Kiley Jade Washnieski

Occupational Therapy Capstones

Background: Youth sport participation plays a significant role in the daily lives of children ages 6-12 (Lee et al., 2018). Participation in organized sports can offer numerous benefits; however, the expectations surrounding youth sports have evolved over time. Increased emphasis on early specialization has intensified training demands and performance pressures placed on youth athletes during critical developmental years (Brenner et al., 2019). Although occupational therapy is well positioned to address both the physical and psychosocial demands of youth sport participation, the profession’s role within this context remains underexplored (Bulan et al., 2025).

Purpose: The purpose of this scholarly project was …

Family-Centered Programming For A Rural Midwest Emergency Shelter: An Occupational Lens, Ariel Kathryn Tix

Occupational Therapy Capstones

Introduction: After a period of decline in homelessness, a startling trend reversal occurred between 2023 and 2024; there was a 39% increase in families experiencing homelessness in the United States (de Sousa & Henry, 2024). Rural homelessness is less visible and often looks different from urban homelessness, which presents challenges that require a different approach (Brott et al., 2019). Individuals experiencing homelessness have challenges in every area of occupation and could benefit from novel strategies and resources. Challenges include parenting, accessing medical care, obtaining permanent housing, community mobility, and meaningful routine development (American Occupational Therapy Association, 2020; Brott et al., …

Expanding Access To Hand Therapy In Rural Wyoming Through Telehealth, Cheyenne Rose Thompson

Occupational Therapy Capstones

Individuals living in rural Wyoming experience significant barriers to accessing specialized hand therapy services, including geographic isolation, limited availability of certified hand therapists, and inconsistent healthcare infrastructure, resulting in delayed rehabilitation and reduced functional outcomes (Hirth et al., 2022; Rural Health Information Hub, 2025). Although telehealth has emerged as a potential solution to improve access, challenges related to clinician training, safety, and adaptation of interventions to virtual environments persist (Feldhacker et al., 2022; Morris, 2024). The purpose of this scholarly project was to develop an evidence-based telehealth hand therapy program to improve access to upper extremity rehabilitation services in rural …

The Lens Of Farmers: Understanding Culture To Improve Occupational Therapy Care, Allison Marie Stephani

Occupational Therapy Capstones

Introduction: Accessible healthcare is essential for farmers due to their limited available time and hazardous job duties (Hildebrand et al., 2019; Hopkins et al., 2023; Salmon et al., 2025; U.S. Department of Agriculture, 2023). Due to the high incidence of injuries that occur within the profession, it is crucial that farmers seek appropriate healthcare services to address these concerns. However, a significant barrier for seeking healthcare assistance is the limited cultural competence among healthcare professionals in understanding the unique needs within farming communities (Gordon et al., 2024; Hildebrand et al., 2019; Hopkins et al., 2023; Purc-Stephenson et al., 2024). The …

Occupational Therapy In Rural North Dakota Schools To Enhance Transition Planning, Kyra M. Schwartz

Occupational Therapy Capstones

Background: Access to services does not guarantee participation. Youth with disabilities, particularly in rural communities, continue to experience disparities in postsecondary outcomes related to employment, education, and independent living. While transition services are available, barriers related to awareness, coordination, and usability limit effective engagement. These challenges highlight a gap between service availability and access within rural systems and contribute to reduced participation outcomes.

Purpose: The purpose of this scholarly project was to develop an occupational therapy– informed, advocacy-driven approach to improve access to and navigation of transition services for youth with disabilities in rural communities.

Methodology: A multi-method, iterative approach …

Swimming With Confidence From An Occupational Therapy Perspective, Emma M. Schultz

Occupational Therapy Capstones

Background: Autism Spectrum Disorder (ASD) is a neurological disorder that impacts thousands of people and their families. Those with an ASD diagnosis demonstrate difficulty with safety awareness are at an increased risk to die due to drowning. Those with autism are often drawn to water for a multitude of reasons especially after an elopement attempt. There has been an increased awareness and development in aquatic therapy to reduce the drowning risks for those with ASD. Occupational therapists have begun to develop interventions that targets basic swimming and water safety. During these interventions, occupational therapists use their skills of activity analysis, …

The Effect Of Sensory Processing And Integration On Engagement In Occupations For Children With Sensory Processing Disorders, Ashley Schindele

Occupational Therapy Capstones

Background: Sensory Processing Disorder (SPD) is a condition where the person is unable to process and respond to sensory information (Guardado & Sergeant, 2023). Children who are lacking sensory integration skills may have more behavior problems due to their inability to regulate their responses (Guardado & Sergeant, 2023; Pfeiffer et al., 2013). Children with SPD may have abnormal sensitivities in any or all the sensory systems which may cause the child to not participate in their occupations (Guardado & Sergeant, 2023; Parham & Mailloux, 2020).

Purpose: The purpose of this scholarly project was to provide parents/caregivers a handout that thoroughly …

Harvesting Health: Cultivating Skills For Wellness In Agricultural Workers, Katie Renee Quinley

Occupational Therapy Capstones

Purpose: The nature of agricultural work is physically demanding and associated with an increased risk of musculoskeletal injury due to repetitive movements, heavy lifting, awkward postures, and prolonged physical labor. Despite the importance of agriculture as a meaningful occupation and major contributor to the workforce, limited resources address the unique physical demands of agricultural labor. The purpose of this scholarly project was to develop a video-based educational resource to promote safety and continued occupational participation in agricultural workers. Additionally, the project aims to assist therapy professionals in implementing ergonomic and task modifications through an accompanying resource guide.

Methodology: A literature …

Enhancing Leisure Opportunities For People With Disabilities In Rural Communities, Joslyn Mary Nordmark

Occupational Therapy Capstones

Purpose. The purpose of this scholarly project was to promote access to leisure opportunities for people with disabilities in rural areas. The author addressed unmet needs among this population considering personal, occupational, environmental, cultural, and socioeconomic factors. The goal was to develop a product that provided opportunities regardless of abilities to promote leisure exploration and participation, social engagement, and life skill development for people with disabilities

Methods. The author conducted a needs assessment through a literature review following the Model of Human Occupation (MOHO), collaborations with site staff, and an on-site observation and environmental analysis. Data was examined to identify …

The Missing Link: Psychosocial Integration In Neuro Ot Care, Emily Nelson

Occupational Therapy Capstones

Introduction: Over 1 in 3 people are affected by neurological conditions, making it the leading cause of illness and disability worldwide (World Health Organization, 2024). Patients are often referred to inpatient rehabilitation to increase independence and functional recovery. There is a need to address psychosocial factors within this setting thus, The Missing Link: Integrating Psychosocial Factors into Neuro OT was created.

Methodology : The capstone is guided by the Model of Human Occupation (MOHO), which emphasizes the dynamic interaction between the person and their environment and its influence on psychosocial factors, personal identity, and competence. A comprehensive needs review was …

Cultivating Connections: Empowering Agricultural Community Members Through Collaborative Care, Kearyn E. Nelsen

Occupational Therapy Capstones

Background: Agriculture and mental health – two words not typically used in the same sentence; however, considering the rate of suicide among those working in the agriculture profession is significantly higher than the general population, the need for both awareness and action is critically important. Despite a lack of research specific to occupational therapy and the agricultural population, occupational therapists on an interprofessional healthcare team are uniquely positioned to serve this population. Interprofessional collaboration is essential when serving agricultural community members, whose needs involve a complexity of physical, mental, social, and environmental factors, each impacting the overall health and well-being …

Occupation-Based Transition Planning Guide For High School Students With Disabilites., Kelsey Milleson

Occupational Therapy Capstones

Background: The transition from high school to adulthood is a critical period influencing independence, employment, and community participation for students with disabilities (Carroll et al., 2025; Rosner et al., 2020). Despite mandates under the Individuals with Disabilities Education Act (IDEA), many students experience poor postsecondary outcomes, including limited employment and increased reliance on caregivers (Benson et al., 2021; U.S. Department of Education, 2020). Effective transition planning should begin early, be individualized, and emphasize real-world skill development such as daily living, vocational skills, and self-advocacy (Cleary & Persch, 2020). However, school-based programs often lack consistency, structure, and performance-based outcome measures, reducing …

Increasing Leisure Exploration In Older Adults As They Age, Jackie Middendorf

Occupational Therapy Capstones

Background: As individuals age, it is common for them to experience deficits that impact how and where they age (Dieuleveult et al., 2017; Nakahara & Yokoi, 2024; Park et al., 2021; Rimland et al., 2016; Szanton et al., 2016). These deficits commonly impact functional mobility and their ability to complete self-cares, leading to them having to leave their homes or receive services (Dieuleveult et al., 2017; Feller & Baker, 2022; Lindquist et al., 2021; Mayo et al., 2021; Spang et al., 2024). Along with deficits with functional mobility and self-cares, older adults experience decreases in their social engagement and leisure …

The Role Of Occupational Therapy In The Prevention Of Sudden Unexpected Infant Death (Suid), Natalie Ryan Mcfarren

Occupational Therapy Capstones

Background: Each year, 3,700 infants die from SUID; this equates to about ten infants per day. SUID is an umbrella term that covers three separate subcategories: suffocation and strangulation in bed, sudden infant death syndrome (SIDS), and unknown (Cribs for Kids, 2026). Suffocation and strangulation in bed is the only subcategory that is 100% preventable with safe sleep practices, while the risk of SIDS can be decreased by adhering to safe sleep guidelines. While the prevalence of SUID has decreased since the 1992 Back to Sleep campaign, current data indicate a plateau, if not a slight increase, in SUID cases …

Digging Into Prevention: An Occupational Therapy Based Work-Related Upper Extremity Injury Prevention Program For Extraction And Mining Industries, Karli Teresa March

Occupational Therapy Capstones

Background: Extraction and mining industries, which play a significant role in the economic structure of Sweetwater County, Wyoming, consistently report some of the highest rates of work-related injury. Upper extremity based musculoskeletal injuries are particularly common and often lead to significant impairment and/or surgical intervention, impacting productivity, increasing lost-workdays, and contributing to long-term health outcomes. These injuries are often due to a dynamic interaction of personal, contextual, and task-based factors including fatigue, level of experience, organizational procedures and policies, repetitive motions, sustained forceful exertions, awkward positioning, and vibration exposure. Current prevention efforts are often reactive rather than proactive, with interventions …

Introduction Of Occupational Therapy Into A Suburban Supportive Housing Organization, Madeline Kuntz

Occupational Therapy Capstones

Abstract: Unhoused individuals experience compounded barriers beyond housing access and are often underserved within occupational therapy practice. This doctoral capstone project partnered with a nonprofit residential program to develop a research-informed onboarding manual grounded in the holistic occupational therapy framework, Model of Human Occupation (MOHO, O’Brien, 2017). The manual was designed to clarify expectations of the supportive housing program, address diverse resident needs, and promote independence as the organization expands. Development was informed by a comprehensive literature review and informal needs assessment of the organization, identifying anticipatory barriers and supports commonly experienced prior to program entry. Key areas of need …

Pathways To Participation: Enhancing Inclusion For Individuals With Idd, Katie Koxlien

Occupational Therapy Capstones

Background: Youth with intellectual and developmental disabilities (IDD) continue to experience barriers to meaningful community participation despite policies promoting inclusive community-based services (Friedman, 2017). Sensory sensitivities, difficulty with transitions, and overstimulating environments frequently limit engagement and increase anxiety or behavioral responses when appropriate supports are not present (Bagatell et al., 2022; Dean et al., 2018; Tint et al., 2017). Research indicates that inclusion requires intentional programming that incorporates structured supports, consistent routines, and opportunities for meaningful engagement (Edwards et al., 2021; Hall, 2016).

Methods: The purpose of this scholarly project was to develop a week long sensory exploration camp for …

Holistic Occupational Therapy Approach In Addressing Women’S Health Needs & Access To Care, Lilja Jurva

Occupational Therapy Capstones

Background: As women across the lifespan experience complex physical, emotional, and occupational challenges related to maternal transitions, mental health needs, chronic conditions, and rural healthcare disparities, occupational therapy is uniquely equipped to address the complex challenges. Services have been proven to be directly correlated to lower incidence of preterm birth, cesarean delivery, low birth weight, excessive gestational weight gain, diabetes mellitus, and hypersensitive disorders, and higher incidence of vaginal delivery. A clear gap for maternal support services was identified in the Grand Forks community through literature review, interviews, and community engagement, leading to the development of NoDak Therapy and Wellness. …

Rebuilding Participation: Trauma-Informed Support For At-Risk Teens, Emily A. Funk

Occupational Therapy Capstones

Background: Over half of our youth population have experienced at least one adverse childhood experience (ACE) before they reach adulthood (Madigan et al., 2025). ACEs are major factors in increasing a child’s chances of making risky lifestyle choices that negatively affect their physical, emotional, and mental health (Atchison & Suarez, 2021; Felitti et al., 1998). Dysregulation, irrational behaviors, poor academic achievements, high levels of stress, and feeling a loss of purpose are some of the challenges that at-risk youth face (Atchison & Suarez, 2021).

Purpose: The purpose of this scholarly project is to develop a toolkit that contains indirect occupational …

Empowering Caregivers: An Occupational Therapy-Informed Educational Program For Dementia Care In Rural Communities, Maria Lynn Johnson

Occupational Therapy Capstones

Purpose: Hospitalization presents significant risks for individuals with dementia, including increased behavioral and psychological symptoms (BPSD), delirium, functional decline, and reduced occupational engagement (Boltz et al., 2023; Teichmann et al., 2019; Zwingmann et al., 2020). Acute care environments are often overstimulating, unfamiliar, and task-oriented, which can exacerbate cognitive impairment and contribute to caregiver distress. Despite strong evidence supporting nonpharmacological, occupation-based interventions, structured engagement opportunities are rarely integrated into acute care workflows (Burgdorf et al., 2023; Faeder et al., 2023). This doctoral capstone project aimed to develop occupation-based dementia activities for use during hospitalization while equipping formal and informal caregivers with …

Quality Of Life Of Individuals Residing In Senior Living Facilities, Meagan R. Danda

Occupational Therapy Capstones

Introduction: Formal caregivers play an essential role in supporting residents’ physical, emotional, and social needs which contribute to overall health and well-being (Spilsbury et al., 2024). Due to these responsibilities, caregivers need to be properly equipped with the knowledge and skills necessary to perform clinical duties with confidence. The purpose of this scholarly project is to develop a product that increases caregiver confidence by providing caregivers with occupational therapy informed education. By enhancing caregivers’ knowledge and skill set, this product may contribute to a supportive environment that fosters resident engagement in meaningful occupations and promotes improved quality of life (QoL) …

Determining Driving Ability Following Traumatic Brain Injury, Shauna M. Corrigan

Occupational Therapy Capstones

Introduction: A traumatic brain injury (TBI) can be a severe injury that causes lasting effects such as visual changes, challenges with concentration and memory, and problems with coordination and balance (Centers for Disease Control, 2024). This can impact an individual’s ability to safely return to the valued occupation of driving. Occupational therapists will commonly assess an individual’s ability to return to drive following a TBI, but they experience challenges in doing so due to a lack of standard method in assessing one’s safety while operating a motor vehicle (Baker et al., 2015; Tamietto et al., 2006; Classen et al., 2009; …